研究者業績

小澤敬也

オザワケイヤ (Keiya Ozawa)

基本情報

所属: 自治医科大学（JMU）教授

学位: 医学博士(東京大学)

J-GLOBAL ID: 200901030330125009
researchmap会員ID: 0000018135

研究キーワード

6

研究分野

1

ライフサイエンス / 血液、腫瘍内科学 /

経歴

72

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学歴

2

- 1977年

東京大学医学部医学科
- 1977年

University of Tokyo Faculty of Medicine

委員歴

7

2000年 - 2001年

国際実験血液学会 ISEH Standing Scientific Program Committee Member
1999年

日本癌学会評議員
1996年

がん分子標的治療研究会世話人
1994年

日本遺伝子治療学会幹事、評議員、プログラム委員
1994年

日本ウイルス学会将来計画委員会(将来構想検討委員会)委員

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受賞

2

MISC

536

Regulation of recombinant human granulocyte colony-stimulating factor production using herpes simplex virus I thymidine kinase gene

Biochem.Biophys.Res.Commun.200:1245-1251,1994.
Recombinant immune interferon inhibits leukemic cell growth by a monocyte-macrophage-mediated mechanism.

Exp.Hematol,13:597-602,1985.
Recombinant human glycosylated granulocyte colony-stimulating factor (rhG-CSF)-combined regimen for allogeneic bone marrow transplantation in refractory acute myeloid leukemia.

Bone Marrow Transplant.13:239-245,1994.
Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia.

Cancer Res.43:2339-2341.1983 .
Quality of life in adult patients after stem cell transplantation.

Int. J. Hematol. 71: 283-289, 2000.
Pure red cell aplasia caused by parvovirus B 19 infection in a renal transplant recipient.

Eur.J.Haematol.54:68-69,1995.
Productive infection by B19 parvovirus of human erythroid bone marrow cells in vitro.

Blood70:384-391,1987.
Production of human granulocyte colony stimulating factor by various kinds of stromal cells in vitro detected by enzyme immunoassay and in situhybridizatio

Stem Cells12:416-423,1994.
Problems in the pathogenesis of aplastic anemia. In. Progress in Bone Marrow Transplantation.

Alan R.Liss,Inc.,p.3-12,1987.
Potential application of dominant negative retinoic acid receptor genes for ex vivo expansion of hematopoietic stem cells.

Gene Ther. Mol. Biol. 3: 293-300, 1999.
Potential application of dominant negative retinoic acid receptor genes for ex vivo expansion of hematopoietic stem cells.

Gene Ther.Mol.Biol.(in press)
Possible pathophysiological roles of G-CSF in myelodysplastic syndromes (MDS): A case report,In.Myelodysplastic Syndrome and Cytokines.

Elsevier Science Publishers B.V.,p.161-166,1991 .
Possible correlation between fusion pattern of BCR/ABL mRNA and clinical response to cx-interferonin chronic myelogenous leukemia.

Leukemia 6:948-951,1992.
Phenotypic conversion of T-lineage lymphoblasts in the lymph node to myeloblasts in the bone marrow during relapse after allogeneic bone marrow transplantation.

Int. J. Hematol. 72: 253-254, 2000.
Pharmacokinetics studies of intravenous glycosylated recombinant human granulocyte colony-stimulating factor in various hematological disorders:

Int.J.Hematol.66:57-67,1997.
Pathophysiological roles of G-CSF. In. Proceedings of the Ist International Congress on Vitamins and Biofactors in Life Science in Kobe,1991

Center for Academic Publications Japan,p.345-348,1992.
Novel transcription map for the B19(human) pathogenic parvovirus.

J.Virol.61:2395-2406,1987.
NH2-terminal pentapeptide of endothelial interleukin 8 is responsible for the induction of apoptosis in leukemic cells and has an antitumor effect in vivo.

Cancer Res. 59: 5651-5655, 1999.
N(G)-monomethyl-L-arginine inhibits erythropoietin gene expression by stimulating GATA-2.

Blood 96: 1716-1722, 2000.
Molecular breakpoints and platelet counts in chronic myeloid leukemia.

Blood 80:556-557,1992.
Modulation of normal myelopoiesisin vitro by retinoic acid. Biochem.

Biophys. Res.Commun,123:128-132,1984.
Microinjection of macromolecules into lenkemic cells by cell fusion technique:

Res. Commun. 130: 257-263, 1985.
Methionine dependency of cell growth in normal and malignant hemopoietic cells.

Cancer Res.42:3090-3092,1982.
Malignant transformation of an IL-3-dependent myeloid cell line by activated oncogenes.

Acta Haematol.Jpn.53:1473-1482,1990.
Long-term tracking of murine hematopoietic cells transduced with a bicistronic retrovirus containing CD24 and EGFP genes.

Gene Ther. 7: 1193-1199, 2000.
Introduction of macromolecules into hemopoietic stem cells with an erythrocyte-ghost-mediated system.

Biochem.Biophys.Res.Commun.128:193-198,1985.
Introduction of foreign genes into hematopoietic cells using retrovirus and adenovirus vectors. In, Cancer Chemotherapy:Challenges for the Future.

Vol. 9 Excerpta Medica,Ltd.p.115-122,1994.
Interleukin-6 and granulocyte colony-stimulating factor synergistically increase peripheral blood progenitor cells in myelosuppressive mice.

Jpn.J.Cancer Res.87:938-944,1996.
Induction of proliferation of human circulating monocytes in vitro by lectin-induced factor(s) from lymphocytes. Biochem.

Biophys.Res.Commun.126:705-711,1985.
Increased radioresistance of FDC-P2 myeloid cells transformed by the activated c-H-rasgene.In, The Mechanism and New Approach on Drug Resistance of Cancer Cells.

Elsevier Science Publishers B.V., p.229-232, 1993.
In vivo effects of recombinant human interleukin-6 in primates: Stimulated production of platelets.

Blood75:1602-1605,1990.
In vitro model of toxin therapy targeted against murine myeloid leukemia cells.

Cancer Chemoth.Pharm.38Suppl.:S37-S39,1996.
In vitro formation of macrophage-epithelioid cells and multinucleated giant cells by 1α, 25-dihydroxyvitamin D3 from human circulating monocytes.

Ann.N.Y.Acad.Sci.465:211-220,1986.
In vitro expansion of murine hemopoietic stem cell population in response to interleukin 3 and interleukin 6. Application to bone marrow transplantation.

Transplantation 48:495-498,1989.
In vitro effects of antineoplastic prostaglandins on human leukemic cell growth and normal myelopoiesis.

Leukemia Res,lO:527-532,1986.
In vitro differentiation of leukemic progenitor cells in various types of acute nonlymphocytic leukemia

Cancer Res.43:2334-2338,1983.
Implantation of genetically manipulated fibroblasts into mice as anti-tumor α-interferon therapy

Cancer Res. 50: 5102-5106, 1990.
Implantation of genetically manipulated fibroblasts into mice as a model of cytokine supplementation gene therapy using human G-CSF and IFN-αcDNAS. In, Molecular Approaches to the Study and Treatment of Human Diseases.

Elsevier Science Publishers B.V.,p.419-428,1992.
Implantation of fibroblasts transfected with human granulocyte colony-stimulating factor (G-CSF)cDNA into mice as a model of cytokine supplement gene therapy.

Blood 74:1274-1280,1989.
Identification of PU. I and Spl as essential transcription factors for the promoter activity of mouse tec gene.

Biochem.Biophys.Res.Commun.234:376-381,1997.
Human granulocyte colony formation in serum-free cultures stimulated with purified recombinant granulocyte colony- stimulating factor.

Exp. Hematol.18:883-887,1990.
Highly-regulated expression of adeno-associated virus large Rep proteins in stable 293 cell lines using the Cre-loxP switching system.

J. Gen. Virol. 80: 2477-2480, 1999.
Hemopoietic precursor cells in erythroleukemia

Stem Cells1:224-232,1981
Hematopoietic stem cell gene therapy: a current overview.

Int. J. Hematol. 69: 227-233, 1999.
Hematopoiesis-supporting ability of a differentiation-inducible stromal cell line of mouse embryo fibroblasts.

Bone Marrow Transplant.12(Suppl.2):29,1993.
HRX gene rearrangement in secondary acute lymphoblastic leukemia.

Leukemia and Lymphoma17:391-399,1995.
HRX gene rearrangement in acute lymphoblastic leukemia after adjuvant chemotherapy of breast cancer.

Blood82:3220-3221,1993.
Green fluorescent protein as a selectable marker of retrovirally transduced hematopoietic progenitors.

Stem Cells 17: 226-232, 1999.
Granulocyte colony-stimulating factor stimulates human mature neutrophilic granulocytes to pre interferon-α.

Blood75:17-19,1990.
Gene transfer into rat renal cells using adeno-associated virus vectors.

Am. J. Nephrol. 20: 242-247, 2000.

所属学協会

40

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共同研究・競争的資金等の研究課題

6

遺伝子治療

ミレニアム・プロジェクト
遺伝子治療

厚生労働科学研究費補助金
遺伝子治療

科学研究費補助金
Gene therapy

Millennium Project
Gene therapy

Health and Labour Sciences Research Grants

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