研究者業績

小澤敬也

オザワケイヤ (Keiya Ozawa)

基本情報

所属: 自治医科大学（JMU）教授

学位: 医学博士(東京大学)

J-GLOBAL ID: 200901030330125009
researchmap会員ID: 0000018135

研究キーワード

6

研究分野

1

ライフサイエンス / 血液、腫瘍内科学 /

経歴

72

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学歴

2

- 1977年

東京大学医学部医学科
- 1977年

University of Tokyo Faculty of Medicine

委員歴

7

2000年 - 2001年

国際実験血液学会 ISEH Standing Scientific Program Committee Member
1999年

日本癌学会評議員
1996年

がん分子標的治療研究会世話人
1994年

日本遺伝子治療学会幹事、評議員、プログラム委員
1994年

日本ウイルス学会将来計画委員会(将来構想検討委員会)委員

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受賞

2

MISC

501

Sialyl-Tn-and neuron-specific enolase-positive minimally differentiated erythroleukemia

Kazuo Muroi, Takahisa Tarumoto, Toshikazu Akioka, Keita Kirito, Tadashi Nagai, Tohru Izumi, Mitsuru Nakamura, Kiyohiko Hatake, Sen-Itiroh Hakomori, Yasusada Miura, Keiya Ozawa

Internal Medicine 39(10) 843-846 2000年
Inhibition of vascular endothelial growth factor activity by transfection with the soluble FLT-1 gene

Hong Chen, Uichi Ikeda, Masahisa Shimpo, Yoshikazu Maeda, Masabumi Shibuya, Keiya Ozawa, Kazuyuki Shimada

Journal of Cardiovascular Pharmacology 36(4) 498-502 2000年
Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathway

Tetsu Akimoto, Eiji Kusano, Toshiya Inaba, Osamu Iimura, Hideaki Takahashi, Hiromi Ikeda, Chiharu Ito, Yasuhiro Ando, Keiya Ozawa, Yasushi Asano

Kidney International 58(1) 269-282 2000年
Adeno-associated virus-mediated vascular endothelial growth factor gene transfer into cardiac myocytes

Yoshikazu Maeda, Uichi Ikeda, Masahisa Shimpo, Masabumi Shibuya, John Monahan, Masashi Urabe, Keiya Ozawa, Kazuyuki Shimada

Journal of Cardiovascular Pharmacology 36(4) 438-443 2000年
A de novo Philadelphia chromosome-positive acute mixed-lineage leukemia with both major and minor BCR/ABL mRNA transcripts

Takahisa Tarumoto, Shigehiko Imagawa, Ken Ohmine, Atsushi Mano, Tadashi Nagai, Masaaki Takatoku, Kazuo Muroi, Kiyohiko Hatake, Keiya Ozawa

American Journal of Hematology 65(1) 72-74 2000年
A switching system regulating subcellular localization of nuclear proteins using a viral protease

Masashi Urabe, Akihiro Kume, Tohru Takahashi, Nobufusa Serizawa, Kiyotake Tobita, Keiya Ozawa

Biochemical and Biophysical Research Communications 266(1) 92-96 1999年12月9日
SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein

Tetsuya Otsuki, Sachiko Kajigaya, Keiya Ozawa, Johnson M. Liu

Biochemical and Biophysical Research Communications 265(3) 630-635 1999年11月30日
Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase

Ken-Ichi Ohya, Sachiko Kajigaya, Akira Kitanaka, Koji Yoshida, Akira Miyazato, Yoshihiro Yamashita, Takeo Yamanaka, Uichi Ikeda, Kazuyuki Shimada, Keiya Ozawa, Hiroyuki Mano

Proceedings of the National Academy of Sciences of the United States of America 96(21) 11976-11981 1999年10月12日
A G-CSF receptor-gyrase B fusion gene: A new type of molecular switch for expansion of genetically modified hematopoietic cells

Akihiro Kume, Keiko Ito, Yasuji Ueda, Mamoru Hasegawa, Masashi Urabe, Hiroyuki Mano, Keiya Ozawa

Biochemical and Biophysical Research Communications 260(1) 9-12 1999年6月24日
Development of a modified selective amplifier gene for hematopoietic stem cell gene therapy

K. M. Matsuda, A. Kume, Y. Ueda, M. Urabe, M. Hasegawa, K. Ozawa

Gene Therapy 6(6) 1038-1044 1999年6月
SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein

Takeshi Inukai, Akira Inoue, Hidemitsu Kurosawa, Kumiko Goi, Tetsuharu Shinjyo, Keiya Ozawa, Mao Mao, Toshiya Inaba, A. Thomas Look

Molecular Cell 4(3) 343-352 1999年
Analysis of C-KIT, TIE and HTK expression on leukemic cells using flow cytometry: A preliminary report

Kazuo Muroi, Toshio Suda, Chizuru Kawano, Youichi Amemiya, Mitsuoki Eguchi, Yasusada Miura, Keiya Ozawa

Leukemia Research 22(9) 827-830 1998年9月
Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro

Dong-Sheng Fan, Matsuo Ogawa, Kunihiko Ikeguchi, Ken-Ichi Fujimoto, Masashi Urabe, Akihiro Kume, Masatoyo Nishizawa, Natsuki Matsushita, Kazutoshi Kiuchi, Hiroshi Ichinose, Toshiharu Nagatsu, Gary J. Kurtzman, Imaharu Nakano, Keiya Ozawa

Neuroscience Letters 248(1) 61-64 1998年5月22日
Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase

Hiroyuki Mano, Ken-Ichi Ohya, Akira Miyazato, Yoshihiro Yamashita, Wataru Ogawa, Johji Inazawa, Uichi Ikeda, Kazuyuki Shimada, Kiyohiko Hatake, Masato Kasuga, Keiya Ozawa, Sachiko Kajigaya

Genes to Cells 3(7) 431-441 1998年
Efficient gene transfer into cardiac myocytes using adeno associated virus (AAV) vectors

Yoshikazu Maeda, Uichi Ikeda, Masahisa Shimpo, Shuichi Ueno, Yoji Ogasawara, Masashi Urabe, Akihiro Kume, Toshihiro Takizawa, Takuma Saito, Peter Colosi, Gary Kurtzman, Kazuyuki Shimada, Keiya Ozawa

Journal of Molecular and Cellular Cardiology 30(7) 1341-1348 1998年
Gene transfer into vascular cells using adeno-associated virus (AAV) vectors

Yoshikazu Maeda, Uichi Ikeda, Yoji Ogasawara, Masashi Urabe, Toshihiro Takizawa, Takuma Saito, Peter Colosi, Gary Kurtzman, Kazuyuki Shimada, Keiya Ozawa

Cardiovascular Research 35(3) 514-521 1997年9月
SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase

Ken-Ichi Ohya, Sachiko Kajigaya, Yoshihiro Yamashita, Akira Miyazato, Kiyohiko Hatake, Yasusada Miura, Uichi Ikeda, Kazuyuki Shimada, Keiya Ozawa, Hiroyuki Mano

Journal of Biological Chemistry 272(43) 27178-27182 1997年
Characterization of the kinase activity essential for tyrosine phosphorylation of p130(Cas) in fibroblasts

Ryuichi Sakai, Tetsuya Nakamoto, Keiya Ozawa, Shin-Ichi Aizawa, Hisamaru Hirai

Oncogene 14(12) 1419-1426 1997年
Molecular cloning and characterization of G-CSF induced gene cDNA

Miyuki Shimane, Kenzaburo Tani, Kazuo Maruyama, Satoshi Takahashi, Keiya Ozawa, Shigetaka Asano

Biochemical and Biophysical Research Communications 199(1) 26-32 1994年2月28日
The Production of Granulocyte Colony-Stimulating Factor and Interleukin 6 by Human Bone Marrow Stromal Cells in Aplastic Anemia

Kenzaburo Tani, Keiya Ozawa, Hiromi Ogura, Satoshi Takahashi, Keisuke Takahashi, Toshihisa Tsuruta, Akira Okano, Yukio Akiyama, Takashi Yoshikubo, Miyuki Shimane, Shigetaka Asano

Tohoku Journal of Experimental Medicine 169(4) 325-334 1993年
Deletion mutagenesis of stem cell factor defines the C-terminal sequences essential for its biological activity

Mitsuo Nishikawa, Arinobu Tojo, Kenji Ikebuchi, Kanako Katayama, Nobuyoshi Fujii, Keiya Ozawa, Shigetaka Asano

Biochemical and Biophysical Research Communications 188(1) 292-297 1992年10月15日
1α, 25-Dihydroxyvitamin D3(calcitriol) stimulates proliferation ofhuman circulating monocytes in vitro.

FEBS Lett.185:9-213,1985. 185(1) 9-13 1985年6月3日
1α,25-Dihydroxy vitamin D3 (calcitriol) stimulates proliferation of human circulating monocytes in vitro

Masataka Ohta, Tetsuro Okabe, Keiya Ozawa, Akio Urabe, Fumimaro Takaku

FEBS Letters 185(1) 9-13 1985年6月3日
A functional role of mitogen-activated protein kinases, Erk1 and Erk2, in the differentiation of a human leukemia cell line, UT-7/GM: A possible key factor for cell fate determination toward erythroid and megakaryocytic lineages.

Int. J. Hematol. 73 : 78-83, 2001.
Gene transfer into nonhuman primate hematopoietic stem cells : implications for gene therapy.

Stem Cells 19 : 12-23, 2001.
g-Rays enhance rAAV-mediated transgene expression and cytocidal effect of AAV-HSVtk / ganciclovir on cancer cells.

Cancer Gene Ther. 8 : 99-106, 2001
Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes and regulates cell cycling as a downstream molecule of TPO signaling.

J. Biol. Chem. 276 : 15082-15089, 2001.
Morphological and physiological restorations of hereditary form of dilated cardiomyopathy by somatic gene therapy. Biochem. Biophys.

Res. Commun. 284 : 431-435, 2001.
Antitumor effect of beta2-microglobulin in leukemic cell-bearing mice via apoptosis-inducing activity : activation of caspase-3 and nuclear factor-kappaB.

Cancer Res. 61 : 4414-4417, 2001.
CD13 is the resistance mechanism for endothelial interleukin-8 inducing apoptosis. In, Cell-Surface Aminopeptidases : Basic and Clinical Aspects. (ed. by Mizutani, S.and Turner, A.J.)

Elsevier Science B.V., p. 177-184, 2001.
Adeno-associated virus-mediated transfer of endothelial nitric oxide synthase gene reduces vasoconstrictive response.

Exp. Clin. Cardiol. 6 : 50-55, 2001.
A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus. Hum.

Gene Ther. 12 : 1047-1061, 2001.
Targeted integration of foreign dna into a defined locus on chromosome 19 in K562 cells using MV-derived components.

Int. J. Hematol. 73 : 469-475, 2001.
Adeno-associated virus-mediated transfer of endothelial nitric oxide synthase gene inhibits protein synthesis of rat ventricular cardiomyocytes. Cardiovas.

Drug Ther. 15 : 19-24, 2001.
Colon cancer with meningeal carcinomatosis and myelodysplastic syndrome in a patient who underwent intensive chemotherapy for acute myelogenous leukemia : a case report.

Jpn. J. Clin. Oncol. 31: 221-225, 2001.
beta₂-Microglobulin identified as an apoptosis-inducing factor and its characterization.

Blood 94: 2744-2753, 1999.
Vrral vectors for gene therapy.

Proeeedings of Bio Japan'96 Symposium.p.139-146,1996.
Unusual tumor formation in the tongue of an acute myelocytic leukemia patient: report of a case.

Oral Med. Pathol. 5: 53-56, 2000.
Ultrastructural cytochemistry of human erythroblasts in culture.

Microscopy15:5-6,1982
Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes.

Mol. Cell. Biol. 19:2754-2762, 1999.
Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor: A preliminary report.

Am.J.Med.86:178-182,1989.
Treatment of myelodysplastic syndrome using recombinant human erythropoietin in combination with short course administration of granulocyte colony-stimulating factor. In, Myelodysplastic Syndromes: Advances in Research and Treatment.

Elsevier Science B.V.p.337-341,1995
Translational regulation of B19 parvovirus capsid protein production by multiple upstream AUG triplets.

J.Biol.Chem.263:I0922-10926,1988.
Transduction of LacZ gene into leukemia cells using viral vectors ofretrovirus and adenovirus.

Leukemia9(Suppl.l):S64-S65,1995.
The use of heterologous promoters for adeno-associated virus (AAV) protein expression in AAV vector production.

Microbiol.Immunol.42:177-185,1998.
The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transf ected cells.

J.Virol.62:2884-2889,1988.
The effect of hydrocortisone on human granulopoiesis in vitro with cytochemical analysis of colonies.

Exp. Hematol.11:114-121,1983.
The alloantigen-specific immunosuppressive activity of estradiol-chlorarnbucil conjugate (KM2210)and its beneficial effect on allogeneic bone marrow transplantation in mice.

Transplantation54:676-681,1992.
Tec protein-tyrosine kinase is involved in the thrombopoietin/c-Mpl signaling pathway.

Exp.Hematol.25:211-216,1997.
Tec protein-tyrosine kinase is an effector molecule ofLyn protein-tyrosine kinase.

FASEBJ.10:637-642,1996.

所属学協会

40

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共同研究・競争的資金等の研究課題

6

遺伝子治療

ミレニアム・プロジェクト
遺伝子治療

厚生労働科学研究費補助金
遺伝子治療

科学研究費補助金
Gene therapy

Millennium Project
Gene therapy

Health and Labour Sciences Research Grants

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