基本情報
- 所属
- 自治医科大学 医学部 環境予防医学講座 准教授
- 学位
- 博士 (地球環境科学)(1996年3月 北海道大学)
- J-GLOBAL ID
- 201001003578757404
- researchmap会員ID
- 6000022617
研究分野
5経歴
6-
2021年1月 - 現在
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2013年4月 - 2020年12月
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2010年4月 - 2013年3月
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2002年9月 - 2010年3月
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1998年11月 - 2002年8月
学歴
3-
1993年4月 - 1996年3月
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1991年4月 - 1993年3月
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1987年4月 - 1991年3月
論文
60-
Chemosphere 368 143745-143745 2024年11月
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Fundamental Toxicological Sciences 11(3) 109-121 2024年
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BMC pediatrics 23(1) 479-479 2023年9月21日BACKGROUND: Numerous studies suggest that sex steroids might play a role in sex disparity observed in allergic diseases in adults. However, whether sex hormones influence allergic diseases in children remains unclear. The aim of the present study was to examine the association of sex steroid hormones with allergic disease in Japanese children. METHODS: The present cross-sectional study included 145 6-year-old children participating in a pilot birth cohort study in the Japan Environment and Children's Study. Data on allergic diseases were obtained from questionnaires, and serum levels of sex steroid hormones and allergen-specific IgE were measured. Logistic regression was performed to evaluate the association of sex hormones with allergic diseases. RESULTS: After adjusted sex, amount of body fat at 6 years, parental history of allergic disease, and exposure to tobacco smoke, serum dehydroepiandrosterone sulfate level was significantly associated with reduced odds of any allergic disease (adjusted odds ratio, 0.58; 95% confidence interval, 0.36-0.93; P = 0.024) and serum follicle-stimulating hormone level was significantly associated with increased odds of any allergic disease (adjusted odds ratio, 2.04; 95% confidence interval, 1.01-4.11, P = 0.046). Dehydroepiandrosterone sulfate level showed a significant association with number of allergic diseases. CONCLUSIONS: The current study findings suggest that sex hormones may play an important role in the development of allergic diseases in prepubertal children.
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Chemosphere 318 137911-137911 2023年3月
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Allergology international : official journal of the Japanese Society of Allergology 71(3) 335-344 2022年2月23日BACKGROUND: Allergen-specific immunoglobulins have a crucial role in allergic diseases. Most wheeze episodes develop before school age, and allergic rhinitis later develops during early elementary school years. However, the clinical background and cytokine/chemokine profiles associated with changes in immunoglobulins during early school-age are poorly understood. METHODS: This study used blood samples from children participating in the JECS Pilot Study. We examined nineteen kinds of aeroallergen-specific immunoglobulins (IgE, IgG1, IgG4, and IgA) levels in patients at age 6 and age 8. Fluctuations of Der f 1- and Cry j 1-specific immunoglobulins levels during the two periods were compared to assess the frequency of allergic statuses and clusters of cytokine/chemokine profiles. RESULTS: The medians of aeroallergen-specific IgE levels did not fluctuate, and almost all IgG1 and IgG4 decreased. In IgA, four (e.g., Der f 1) increased, whereas the other four (e.g., Cry j 1) decreased. The ratio of the Der f 1-specific IgG1 level at age 8 to that at age 6 was higher in children with poor asthma control than in children with better asthma control. Moreover, the cytokine/chemokine cluster with relatively lower IL-33 and higher CXCL7/NAP2 was associated with lower Der f 1- and Cry j 1-specific IgG4 levels, but not IgE levels. CONCLUSIONS: The cluster of cytokine/chemokine profiles characterized by lower IL-33 and higher CXCL7/NAP2 was associated with the maintenance of aeroallergen-specific IgG4 levels. This result provides a basis for considering the control of aeroallergen-specific immunoglobulins.
MISC
15-
CELL 166(3) 782-782 2016年7月
共同研究・競争的資金等の研究課題
8-
日本学術振興会 科学研究費助成事業 2021年7月 - 2023年3月
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日本学術振興会 科学研究費助成事業 2020年4月 - 2023年3月
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科学研究費補助金 基盤研究(C) 2015年4月 - 2018年3月
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科学研究費補助金 基盤研究(C) 2009年4月 - 2012年3月
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日本学術振興会 科学研究費助成事業 2008年 - 2012年