三重野 牧子

Background: Most hemophiliacs living with HIV are co-infected with HCV. In their clinical practice, the long-term effects of anti-HIV and anti-HCV therapies have not been sufficiently investigated. Objective: This study aimed to evaluate changes in HIV RNA and HCV RNA levels and the prognosis in hemophiliacs living with HIV over 24 years in Japan. Methods: We used cohort study data of 578 hemophiliacs living with HIV. We analyzed trends in HIV RNA levels between the fiscal years 1997 and 2008 (first follow-up), and trends in HIV RNA and HCV RNA levels between the fiscal years 2009 and 2020 (second follow-up). Mortality rates by HIV RNA and HCV RNA levels were calculated from 11,207 observed person-years and 194 deaths. Results: The percentage of HIV RNA levels <400 copies/mL rose in the first period of follow-up, and the percentage of HCV RNA-negative rose in the second period of follow-up. The participants with HIV RNA levels <400 copies/mL had a significantly lower mortality rate than the others, with a ratio of 0.46 in the first period. HCV antibody-positive participants who were HCV RNA-negative had a significantly lower mortality rate than those who were HCV RNA-positive, with a ratio of 0.47 in the second period. Conclusion: After the introduction of combination anti-HIV therapy over 24 years in hemophiliacs living with HIV, HIV RNA levels decreased in the first half of this period, resulting in decreased mortality. Additionally, HCV RNA levels decreased in the second half of this study period, resulting in even further decreased mortality.

The predominant histological subtype of breast mucinous carcinoma in older women is type B (hypercellular type), and, in younger women, it is type A (hypocellular type). The characteristics of mucinous carcinomas of the same histological subtype may differ between older and younger women. This study aims to systematically clarify the pathological/immunohistochemical features of mucinous carcinomas. A total of 21 surgical cases of mucinous carcinoma (type A/B: 9/12 cases) in the older group (≥65 years) and 16 cases (type A/B: 14/2 cases) in the younger group (≤55 years) (n = 37) were included. Gross cystic disease fluid protein-15 (GCDFP-15) and eight other markers were used for immunostaining. The GCDFP-15-positive rate in the older group was high regardless of the histological subtype (type A, 77.8%; type B, 91.7%). The GCDFP-15 positivity in the older group was significantly higher than that in the younger group (p < 0.001 for Allred score). Among type A, GCDFP-15 positivity was significantly higher in the older group than in the younger group (p = 0.042 for the Allred score and p = 0.007 for the positivity rate). The present results suggest that GCDFP-15 expression characterizes mucinous carcinomas in older women.

目的 患者調査の総患者数の推計方法は1990年頃の診療状況に基づくことから、見直しの必要性が指摘されている。最近の医療施設の曜日別診療状況を観察するとともに、推計方法の調整係数(平日の調査による再来外来患者数を1 週間の平均再来外来患者数に調整する係数)について、1週間のうちで日曜が休診の想定による現行値(6/7)、土曜の午後と日曜が休診の想定による代替値(5.5/7)の適切性を検討した。方法 2005〜2017年の患者調査と医療施設調査を利用した。患者調査による平日1日の再来外来患者数に対する、医療施設調査による1ヵ月間の平均再来外来患者数の比(調整係数の相当値と呼ぶ)を算定した。結果 2017年の診療施設割合をみると、病院では午前・午後・18〜19時ともに月〜金曜でほぼ一定であり、土曜でそれより低かった。一般診療所と歯科診療所では午前・午後・18〜19時ともに月・火・水・金曜でほぼ一定、木曜と土曜でそれより低かった。2005年と2017年の診療施設割合の差をみると、病院・一般診療所・歯科診療所、月〜日曜と祝日の午前・午後・18〜19時ともに-4〜5%の範囲内であった。2005〜2017年の調整係数の相当値は病院で平均6.2/7(範囲6.1/7〜6.3/7)、一般診療所で同5.8/7(5.7/7〜6.0/7)、歯科診療所で同4.7/7(4.4/7〜5.0/7)であった。結論 2005〜2017年の曜日別診療施設割合は病院、一般診療所、歯科診療所の間に相違がみられたが、年次間ではほぼ一定傾向であった。調整係数としては、代替値への変更が支持されず、また、歯科疾患の推計に課題があるものの、現行値が比較的適切であると示唆された。(著者抄録)

The intermediate filament nestin is upregulated in stem/progenitor cells and cancers, and regulates cell proliferation, migration, invasion and stemness. The present study comparatively analyzed serial autopsies of Japanese patients (n=2,206; males, 1,225; females, 981; median, 80.7 years old; range, 33-104 years old) with malignant tumors of whole organs, with respect to the clinical information, and 5 single nucleotide polymorphisms of the nestin gene. p.A1199P associated with pancreatic cancer (odds ratio, 4.4; 95% confidence interval, 1.9-10.0, P=0.001) while it did not associate with malignant neoplasms in other organs. p.A1199P did not associate with precancerous lesions of the pancreas. Single nucleotide polymorphisms of nestin were not associated with sex, drinking, smoking, or body weight. In conclusion, the amino acid 1,199 of nestin is localized in the tail structure of the filament and polymerizes with other intermediate filament proteins. The present results suggest that missense variations of nestin affect pancreatic carcinogenesis in Japanese patients.

We comparatively analyzed serially autopsied, elderly Japanese patients (n = 2205) with pancreatic intraepithelial neoplasias (PanINs) and pancreatic ductal adenocarcinomas (PDACs) on the basis of their pancreatic lesions, clinical information, and single nucleotide polymorphisms (SNPs). The incidence of PanIN-1, -2, -3, and PDACs in these patients was 55%, 12%, 1.4%, and 2.4%, respectively. The occurrence of PanINs was associated with female sex, increasing age, and lower body mass index. We did not identify any common SNPs between PanINs and PDACs. There were no common SNPs associated with PanINs and PDACs between men and women. In previously reported pancreatic cancer-associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. Six SNPs (rs7016880, rs10096633, rs10503669, rs12678919, rs17482753, rs328) that were correlated with blood lipid levels were associated with the risk for PDACs. Our data suggest that different clinicopathological characteristics and predispositions may affect pancreatic carcinogenesis in elderly Japanese patients.

Aim: We aimed to study a single nucleotide polymorphism (SNP), rs2106261, in the transcription factor gene, ZFHX3, in atrial fibrillation (AF) and other related phenotypes by phenome scanning in a Japanese population. Method: We retrieved consecutive autopsy data (n = 2433, mean age = 80 years) from the Japanese SNP database for geriatric diseases (JG-SNP). Clinical data, including an AF diagnosis, were collected from medical charts. Genotyping was performed with the DNA chip method. We also analyzed 42 pathological and 26 clinical phenotypes, including cerebral infarctions (Cls) and lung thromboembolisms (LT5), diagnosed by macroscopic inspection during the autopsy. Result: Among the 2433 patients with available data, 18.6% had AF, 29.4% had CI, and 4.9% had LT phenotypes. The A allele of the rs2106261 SNP was significantly associated with AF, after adjusting for age, sex, diabetes, hypertension, and smoking (AA + AG/GG, OR = 1.51, 95%Cl: 1.16-1.97, p = 0.002). In the entire cohort, CI was not associated with rs2106261 (p = 0.14). However, among patients under 80 years old, rs2106261 was significantly associated with CI (AA + AG/GG, OR = 1.57, 95%CI: 1.09-2.26, p = 0.01). LT was also associated with rs2106261 (AA + AG/GG, OR = 1.99, 95%CI: 1.31-3.01, p = 0.001). Associations between rs2106261 and CI and LT remained positive after adjusting for the presence of AF, which indicated that this SNP variant might serve as an independent risk marker. Conclusion: We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for AF and AF-related phenotypes. The roles of this variant in the development of AF and its related phenotypes warrant further investigation. (C) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

目的 東日本大震災前後の病院の患者数の変化について,岩手県,宮城県と福島県の3県で,沿岸部と沿岸部以外の市町村別に,病院報告に基づいて検討した。方法 平成20年10月〜25年2月の病院報告を統計法33条による調査票情報の提供を受けて利用した。東日本大震災から2年間における,地域別の病院の1日平均在院患者数,1日平均外来患者数の変化について,施設の廃止・休止,継続,開設・再開の状況別に分類して観察した。結果 3県の沿岸部の市町村において,震災1年後の1日平均在院患者数は,震災前と比較して岩手県で3.1%,宮城県で8.4%,福島県で25.1%の減少であった。岩手県と宮城県の減少ではその大部分が病院の廃止・休止であるのに対し,福島県では廃止・休止と継続病院での減少の両方がみられた。震災2年後の1日平均在院患者数は大きな増加がみられなかった。3県の沿岸部以外の市町村では震災1年後に横ばい傾向,2年後に減少傾向がみられた。3県沿岸部の市町村において,震災1年後の1日平均外来患者数は,岩手県では4.2%,宮城県で1.0%,福島県で19.3%の減少であった。岩手県と宮城県では廃止・休止による減少分が継続病院や開設・再開病院での増加によって圧縮されていたが,福島県では,継続病院や開設・再開病院による増加はほとんどなかった。震災2年後の1日平均外来患者数はさらに減少していた。一方,3県の沿岸部以外の市町村では震災1年後に増加し,いずれの県においても継続病院での患者数の増加が大きかったが,震災2年後には減少していた。結論 3県の沿岸部において,震災前と比較して,震災1年後は患者数が大きく減少し,それには施設の廃止・休止と継続病院の患者数の変化が関連したことが示された。震災2年後では,1年後と比べて大きな増加はみられなかった。(著者抄録)

A genetic risk score (GRS) was developed for predicting fracture risk based on lifetime prevalence of femoral fractures in 924 consecutive autopsies of Japanese males. A total of 922 non-synonymous single nucleotide polymorphisms (SNPs) located in 62 osteoporosis susceptibility genes were genotyped and evaluated for their association with the prevalence of femoral fracture in autopsy cases. GRS values were calculated as the sum of risk allele counts (unweighted GRS) or the sum of weighted scores estimated from logistic regression coefficients (weighted GRS). Five SNPs (alpha-EY-iduronidase rs3755955, C7orf58 rs190543052, homeobox C4 rs75256744, G patch domain-containing gene 1 rs2287679, and Werner syndrome rs2230009) showed a significant association (P &lt; 0.05) with the prevalence of femoral fracture in 924 male subjects. Both the unweighted and weighted GRS adequately predicted fracture prevalence; areas under receiver-operating characteristic curves were 0.750 [95 % confidence interval (CI) 0.660-0.840] and 0.770 (95 % CI 0.681-0.859), respectively. Multiple logistic regression analysis revealed that the odds ratio (OR) for the association between fracture prevalence and unweighted GRS aeyen3 (n = 124) was 8.39 (95 % CI 4.22-16.69, P &lt; 0.001) relative to a score &lt; 3 (n = 797). Likewise, the OR for a weighted GRS of 6-15 (n = 135) was 7.73 (95 % CI 3.89-15.36, P &lt; 0.001) relative to scores of 0-5 (n = 786). The GRS based on risk allele profiles of the five SNPs could help identify at-risk individuals and enable implementation of preventive measures for femoral fracture.

The transporter associated with antigen processing 2 (TAP2) gene is involved in the immunological response to tuberculosis (TB) infection. Variations in the TAP2 gene have been associated with TB infection in small population studies in India, Columbia, and Korea. We investigated the association of TAP2 polymorphisms with TB susceptibility in an elderly Japanese population. We analyzed samples from consecutive autopsy cases (n = 1850) registered in the Japanese Geriatric SNP Research database. TB was diagnosed pathologically by TB granuloma on autopsy samples. There were 289 cases and 1529 controls. Twenty-four single nucleotide variations (SNVs), including four missense variations in the TAP2 region, were genotyped using the Illumina Infinium Human Exome BeadChip array. Of the 24 SNVs in the TAP2 gene, rs4148871, rs4148876 (R651C), and rs2857103 showed statistically significant associations with TB susceptibility, and rs4148871 and rs2857103 also showed significant genotypic associations in a dominant allele model adjusted for age, sex, and smoking. Haplotype analysis showed that TAP2 allele *0103 conferred an increased TB risk (OR = 1.48, p = 0.0008), while the TAP2 *0201 allele was protective against TB (OR = 0.73, p = 0.0007). Our results suggest that TAP2 polymorphisms influence TB susceptibility in a Japanese population.

The transporter associated with antigen processing 2 (TAP2) gene is involved in the immunological response to tuberculosis (TB) infection. Variations in the TAP2 gene have been associated with TB infection in small population studies in India, Columbia, and Korea. We investigated the association of TAP2 polymorphisms with TB susceptibility in an elderly Japanese population. We analyzed samples from consecutive autopsy cases (n = 1850) registered in the Japanese Geriatric SNP Research database. TB was diagnosed pathologically by TB granuloma on autopsy samples. There were 289 cases and 1529 controls. Twenty-four single nucleotide variations (SNVs), including four missense variations in the TAP2 region, were genotyped using the Illumina Infinium Human Exome BeadChip array. Of the 24 SNVs in the TAP2 gene, rs4148871, rs4148876 (R651C), and rs2857103 showed statistically significant associations with TB susceptibility, and rs4148871 and rs2857103 also showed significant genotypic associations in a dominant allele model adjusted for age, sex, and smoking. Haplotype analysis showed that TAP2 allele *0103 conferred an increased TB risk (OR = 1.48, p = 0.0008), while the TAP2 *0201 allele was protective against TB (OR = 0.73, p = 0.0007). Our results suggest that TAP2 polymorphisms influence TB susceptibility in a Japanese population.

日本の臨床試験に関する現状を踏まえ、国立国際医療研究センター医学統計研究室(NCGM)では、医学統計コンサルテーション業務の標準業務手順書を作成した。この運用開始から1年間(2014年1〜12月)のコンサルテーション業務実施状況とその内容について縦断的に実態を調査した。調査対象はNCGM、自治医科大学情報センター、順天堂大学臨床研究センターで受け付けて、対面式で行われた統計コンサルテーションとした。どの施設も臨床研究の相談が多く、研究デザインの段階での相談よりもデータ取得後の解析方法や報告書作成に関する相談が多かった。無資金の研究の相談もあった。コンサルティングを申し込む診療科にはある程度偏りがあったため、施設ごとにウェイトをおいて専門家を養成するなどの工夫は可能と思われた。

Background: Cause of death (COD) information taken from death certificates is often inaccurate and incomplete. However, the accuracy of Underlying CODs (UCODs) recorded on death certificates has not been comprehensively described when multiple diseases are present. Methods: A total of 450 consecutive autopsies performed at a geriatric hospital in Japan between February 2000 and August 2002 were studied. We evaluated the concordance rate, sensitivity, and specificity of major UCODs (cancer, heart disease, and pneumonia) reported on death certificates compared with a reference standard of pathologist assessment based on autopsy data and clinical records. Logistic regression analysis was performed to assess the effect of sex, age, comorbidity, and UCODs on misclassification. Results: The concordance rate was relatively high for cancer (81%) but low for heart disease (55%) and pneumonia (9%). The overall concordance rate was 48%. Sex and comorbidity did not affect UCOD misclassification rates, which tended to increase with patient age, although the association with age was also not significant. The strongest factor for misclassification was UCODs (P &lt; 0.0001). Sensitivity and specificity for cancer were very high (80% and 96%, respectively), but sensitivity for heart disease and pneumonia was 60% and 46%, respectively. Specificity for each UCOD was more than 85%. Conclusions: Researchers should be aware of the accuracy of COD data from death certificates used as research resources, especially for cases of elderly patients with pneumonia.

Background Abdominal aortic aneurysm (AAA) is a multifactorial disease with strong genetic components. Various genetic loci have been associated with clinical AAA, but few studies have investigated pathological AAA, an intermediate phenotype of the disease. Methods We examined 2263 consecutive autopsies of older Japanese subjects from a study on geriatric diseases in Japanese individuals (The JG-SNP study). The presence of AAA was determined with a pathological diagnosis during autopsy. Single nucleotide variants (SNVs) associated with AAA were determined with an Illumina HumanExome Beadchip array. Logistic regression analyses were performed to determine genetic associations. Age, gender, and other risk factors of AAA were analyzed as covariates. Results 118 subjects with AAA and 2145 subjects without AAA were analyzed in a case-control setting. No variants reached significance after applying the Bonferroni correction (P &lt; 2.05x10(-6)). The strongest associations were found with rs3750092 (p.E321G, OR: 0.36, 95% CI: 0.24-0.56, P = 6.09 x 10(-6)), a variant in the WAS/WASL interacting protein family 3 (WIPF3), and with rs1051338 (p. T16P, OR: 2.50, 95% CI: 1.70-3.66, P = 2.79 x 10(-6)) and rs2246942 (intronic, OR: 2.32, 95% CI: 1.58-3.41, P = 1.61 x 10(-5)), variants in the lysosomal acid lipase A (LIPA). LIPA is essential for macrophage cholesterol metabolism. Immunohistological analyses of WIPF3 protein in AAA samples from three subjects revealed that WIPF3 was expressed in macrophages of atheromatous plaques. Conclusions This study suggests that WIPF3 and LIPA, both of which are expressed in the macrophages are involved in pathological AAA. These results should be regarded as hypothesis-generating; thus, replication study is warranted.

It has been unclear whether the prevalence of disability is higher in an area affected by natural disaster than in other areas even if more than one year has passed since the disaster. The aim of this ecological study was to examine whether the rate of increase in disability prevalence among the older population was higher in disaster-stricken areas during the 3 years after the Great East Japan Earthquake (GEJE) and tsunami. This analysis used public Long-term Care Insurance (LTCI) data covering 1570 municipalities. "Disaster areas" were considered to be the three prefectures most affected by the earthquake and tsunami: Iwate, Miyagi, and Fukushima. The outcome measure was the number of aged people (&gt;= 65 years) with LTCI disability certification. Rates of change in disability prevalence from January 2011 to January 2014 were used as the primary outcome variable, and compared by analysis of covariance between "coastal disaster areas", "inland disaster areas" and "non-disaster areas". The mean rate of increase in disability prevalence in coastal (14.7%) and inland (10.0%) disaster areas was higher than in non-disaster areas (6.2%) (P &lt; 0.001). During the 3 years after the earthquake, the increase of disability prevalence from before the GEJE continued to be higher in the disaster-stricken areas. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Werner syndrome is a rare autosomal recessive disorder caused by mutations in the human WRN gene and characterized by the early onset of normal aging symptoms. Given that patients with this disease exhibit osteoporosis, the present study aimed to determine whether the WRN gene contributes to the etiology of osteoporosis. A genetic association study of eight non-synonymous polymorphisms in the WRN gene and the incidence of femoral fracture was undertaken in 1,632 consecutive Japanese autopsies in which 140 patients had experienced the fracture during their lifetime. The results were validated in 251 unrelated postmenopausal Japanese women with osteoporosis and 269 non-institutionalized, community-dwelling Japanese adults. A statistically significant association was observed between rs2230009 (c.340G &gt; A)-which results in a Val to Ile substitution-and fracture risk; the incidence of femoral fracture increased dose-dependently with the number of A alleles (p = 0.0120). Femoral neck bone and whole bone densities were lower among postmenopausal women with osteoporosis and community-dwelling adults, respectively, if they were of the AG instead of the GG genotype. The results suggest that Japanese subjects bearing at least one A allele of rs2230009 of the WRN gene are at a significantly higher risk of femoral fracture, possibly due to decreased bone density.

BACKGROUND: Many genetic and environmental factors are involved in the etiology of nicotine dependence. Although several candidate gene variations have been reported by candidate gene studies or genome-wide association studies (GWASs) to be associated with smoking behavior and the vulnerability to nicotine dependence, such studies have been mostly conducted with subjects with European ancestry. However, genetic factors have rarely been investigated for the Japanese population as GWASs. To elucidate genetic factors involved in nicotine dependence in Japanese, the present study comprehensively explored genetic contributors to nicotine dependence by using whole-genome genotyping arrays with more than 200,000 markers in Japanese subjects. RESULTS: The subjects for the GWAS and replication study were 148 and 374 patients, respectively. A two-stage GWAS was conducted using the Fagerström Test for Nicotine Dependence (FTND), Tobacco Dependence Screener (TDS), and number of cigarettes smoked per day (CPD) as indices of nicotine dependence. For the additional association analyses, patients who underwent major abdominal surgery, patients with methamphetamine dependence/psychosis, and healthy subjects with schizotypal personality trait data were recruited. Autopsy specimens with various diseases were also evaluated. After the study of associations between more than 200,000 marker single-nucleotide polymorphisms (SNPs) and the FTND, TDS, and CPD, the nonsynonymous rs2653349 SNP (located on the gene that encodes orexin [hypocretin] receptor 2) was selected as the most notable SNP associated with FTND, with a p value of 0.0005921 in the two-stage GWAS. This possible association was replicated for the remaining 374 samples. This SNP was also associated with postoperative pain, the initiation of methamphetamine use, schizotypal personality traits, and susceptibility to goiter. CONCLUSIONS: Although the p value did not reach a conventional genome-wide level of significance in our two-stage GWAS, we obtained significant results in the subsequent analyses that suggest that the rs2653349 SNP (Val308Ile) could be a genetic factor that is related to nicotine dependence and possibly pain, schizotypal personality traits, and goiter in the Japanese population.

目的 岩手県,宮城県,福島県の3県における東日本大震災前後の医療施設の廃止・休止状況について,医療施設調査に基づいて検討した。方法 平成20〜23年医療施設調査を統計法33条による調査票情報の提供を受けて利用した。東日本大震災前の2008年10月〜2011年2月と震災後の2011年3〜9月において,各月の開設・再開と廃止・休止の医療施設数を観察するとともに,震災後の超過の廃止・休止の医療施設数およびその在院患者数と外来患者数を推計した。結果 3県において,各月の廃止・休止の医療施設数は,震災前では震災直前の施設数の0.0〜0.5%であったが,震災後に沿岸部の市町村で著しく増加した。沿岸部の市町村では,震災後の超過の廃止・休止医療施設数は約250施設(震災直前の医療施設の12.3%),その在院患者数は約2,140人/日(同11.2%)と外来患者数は約8,840人/日(同11.3%)と推計された。沿岸部以外の市町村では,震災後の超過の廃止・休止医療施設数,在院患者数と外来患者数はそれぞれ震災直前の医療施設の1.2%,0.1%,0.8%と見積もられた。結論 3県の沿岸部の市町村では,東日本大震災後に医療施設の廃止・休止が著しく増加し,その超過分は震災直前の医療施設の10%を超えると推計された。(著者抄録)

&lt;b&gt;目的&lt;/b&gt; 国民生活基礎調査の世帯数と患者調査の推計患者数について，東日本大震災によって調査対象から除外された地域の補完を行った。&lt;br/&gt;&lt;b&gt;方法&lt;/b&gt; 国民生活基礎調査において，東日本大震災によって調査対象から除外された2011年の岩手県・宮城県・福島県と2012年の福島県の世帯数について，前後の大規模調査年の情報を用いて線型内挿法で補完した。2011年における宮城県と福島県の推計患者数について，同年の患者調査（宮城県の石巻・気仙沼医療圏と福島県が調査対象から除外）と2012年の福島県患者調査，2011年と2012年の医療施設調査と病院報告を用いて補完した。&lt;br/&gt;&lt;b&gt;結果&lt;/b&gt; 全国の世帯数（各年 6 月時点）における補完値は2011年で48,732千世帯，2012年で48,874千世帯であった。世帯構造別の世帯数において，2011年と2012年の調査値が前後の年次

&lt;b&gt;目的&lt;/b&gt; 国民生活基礎調査の世帯数と患者調査の推計患者数について，東日本大震災によって調査対象から除外された地域の補完を行った。&lt;br/&gt;&lt;b&gt;方法&lt;/b&gt; 国民生活基礎調査において，東日本大震災によって調査対象から除外された2011年の岩手県・宮城県・福島県と2012年の福島県の世帯数について，前後の大規模調査年の情報を用いて線型内挿法で補完した。2011年における宮城県と福島県の推計患者数について，同年の患者調査（宮城県の石巻・気仙沼医療圏と福島県が調査対象から除外）と2012年の福島県患者調査，2011年と2012年の医療施設調査と病院報告を用いて補完した。&lt;br/&gt;&lt;b&gt;結果&lt;/b&gt; 全国の世帯数（各年 6 月時点）における補完値は2011年で48,732千世帯，2012年で48,874千世帯であった。世帯構造別の世帯数において，2011年と2012年の調査値が前後の年次

&lt;b&gt;目的&lt;/b&gt; 国民生活基礎調査の世帯数と患者調査の推計患者数について，東日本大震災によって調査対象から除外された地域の補完を行った。&lt;br/&gt;&lt;b&gt;方法&lt;/b&gt; 国民生活基礎調査において，東日本大震災によって調査対象から除外された2011年の岩手県・宮城県・福島県と2012年の福島県の世帯数について，前後の大規模調査年の情報を用いて線型内挿法で補完した。2011年における宮城県と福島県の推計患者数について，同年の患者調査（宮城県の石巻・気仙沼医療圏と福島県が調査対象から除外）と2012年の福島県患者調査，2011年と2012年の医療施設調査と病院報告を用いて補完した。&lt;br/&gt;&lt;b&gt;結果&lt;/b&gt; 全国の世帯数（各年 6 月時点）における補完値は2011年で48,732千世帯，2012年で48,874千世帯であった。世帯構造別の世帯数において，2011年と2012年の調査値が前後の年次

&lt;b&gt;目的&lt;/b&gt; 国民生活基礎調査の世帯数と患者調査の推計患者数について，東日本大震災によって調査対象から除外された地域の補完を行った。&lt;br/&gt;&lt;b&gt;方法&lt;/b&gt; 国民生活基礎調査において，東日本大震災によって調査対象から除外された2011年の岩手県・宮城県・福島県と2012年の福島県の世帯数について，前後の大規模調査年の情報を用いて線型内挿法で補完した。2011年における宮城県と福島県の推計患者数について，同年の患者調査（宮城県の石巻・気仙沼医療圏と福島県が調査対象から除外）と2012年の福島県患者調査，2011年と2012年の医療施設調査と病院報告を用いて補完した。&lt;br/&gt;&lt;b&gt;結果&lt;/b&gt; 全国の世帯数（各年 6 月時点）における補完値は2011年で48,732千世帯，2012年で48,874千世帯であった。世帯構造別の世帯数において，2011年と2012年の調査値が前後の年次