医学部 外科学講座

岡田 憲樹

オカダ ノリキ  (NORIKI OKADA)

基本情報

所属
自治医科大学 移植外科 助教

J-GLOBAL ID
201401004869653237
researchmap会員ID
B000238308

外部リンク

学歴

 2

論文

 293
  • Taiichi Wakiya, Yasunaru Sakuma, Yasuharu Onishi, Yukihiro Sanada, Noriki Okada, Yuta Hirata, Toshio Horiuchi, Takahiko Omameuda, Kiichiro Takadera, Naohiro Sata
    Scientific reports 14(1) 6753-6753 2024年3月21日  
    The liver and pancreas work together to recover homeostasis after hepatectomy. This study aimed to investigate the effect of liver resection volume on the pancreas. We collected clinical data from 336 living liver donors. They were categorized into left lateral sectionectomy (LLS), left lobectomy, and right lobectomy (RL) groups. Serum pancreatic enzymes were compared among the groups. Serum amylase values peaked on postoperative day (POD) 1. Though they quickly returned to preoperative levels on POD 3, 46% of cases showed abnormal values on POD 7 in the RL group. Serum lipase levels were highest at POD 7. Lipase values increased 5.7-fold on POD 7 in the RL group and 82% of cases showed abnormal values. The RL group's lipase was twice that of the LLS group. A negative correlation existed between the remnant liver volume and amylase (r = - 0.326)/lipase (r = - 0.367) on POD 7. Furthermore, a significant correlation was observed between POD 7 serum bilirubin and amylase (r = 0.379)/lipase (r = 0.381) levels, indicating cooccurrence with liver and pancreatic strain. Pancreatic strain due to hepatectomy occurs in a resection/remnant liver volume-dependent manner. It would be beneficial to closely monitor pancreatic function in patients undergoing a major hepatectomy.
  • Lijian Chen, Hajime Uchida, Ryuji Komine, Tasuku Kodama, Toshimasa Nakao, Noriki Okada, Yusuke Yanagi, Seiichi Shimizu, Syed Abbas, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara
    Pediatric transplantation 28(1) e14640 2024年2月  
    BACKGROUND: COACH syndrome is a rare autosomal recessive genetic disease characterized by liver fibrosis, which leads to severe complications related to portal hypertension. However, only a few patients with COACH syndrome undergoing liver transplantation (LT) have been reported. MATERIALS AND METHODS: We herein report the outcomes of four children who underwent LT for COACH syndrome at our institute and review three previously reported cases to elucidate the role of LT in COACH syndrome. RESULTS: All four patients in our institute were female, and three received living donors LT. All patients were diagnosed with COACH syndrome by genetic testing. LT was performed in these patients at 3, 7, 9, and 14 years old. The indication for LT was varices related to portal hypertension in all patients. One showed an intrapulmonary shunt. Blood tests revealed renal impairment due to nephronophthisis in three patients, and one developed renal insufficiency after LT. The liver function was maintained in all patients. A literature review revealed detailed information for three more patients. The indication for LT in these three cases was portal hypertension, such as bleeding from esophageal varices. One patient had chronic renal failure on hemodialysis at LT and underwent combined liver and kidney transplantation. Of these three previous patients, one died from hepatic failure due to de novo HCV infection 3 years after LT. CONCLUSIONS: LT should be considered an effective treatment for COACH syndrome in patients with severe portal hypertension. However, a detailed follow-up of the renal function is necessary.
  • 平田 雄大, 眞田 幸弘, 大西 康晴, 岡田 憲樹, 堀内 俊男, 大豆生田 尚彦, 佐久間 康成, 佐田 尚宏
    日本小児外科学会雑誌 59(7) 1058-1063 2023年12月  
    腸管重積型逆流防止弁付加手術を行った胆道閉鎖症(BA)において,挙上空腸狭窄が難治性胆管炎の契機となり,生体肝移植(LDLT)を施行した2例を報告する.【症例1】15歳女児.生後1ヵ月時にBAに対して肝門部空腸吻合術を施行したが,胆汁排泄不良で生後2ヵ月時に逆流防止弁付き再吻合術を施行した.術後15年時に挙上空腸狭窄による難治性胆管炎に対してイレウス管を留置したが,肝内胆管数珠状拡張と黄疸は改善せず,LDLTを施行した.【症例2】26歳男性.生後4ヵ月時にBAに対して逆流防止弁付き肝門部空腸吻合術を施行した.術後25年時に黄疸を伴う胆管炎が出現したため,挙上空腸狭窄に対してENBDチューブを留置したが,胆管炎は改善せず,LDLTを施行した.逆流防止弁は長期BAにおいて挙上空腸狭窄による難治性胆管炎の原因になることがある.(著者抄録)
  • 堀内 俊男, 眞田 幸弘, 高寺 樹一朗, 大豆生田 尚彦, 平田 雄大, 岡田 憲樹, 脇屋 太一, 大西 康晴, 三谷 忠宏, 熊谷 秀規, 佐久間 康成, 佐田 尚宏
    日本小児栄養消化器肝臓学会雑誌 37(Suppl.) 86-86 2023年10月  
  • 眞田 幸弘, 佐久間 康成, 大西 康晴, 脇屋 太一, 岡田 憲樹, 平田 雄大, 堀内 俊男, 片野 匠, 大豆生田 尚彦, 高寺 樹一朗, 関谷 菜津美, 吉田 幸世, 佐田 尚宏
    小児外科 55(6) 609-617 2023年6月  

MISC

 74

共同研究・競争的資金等の研究課題

 3