基本情報
- 所属
- 自治医科大学 医学部産科婦人科学講座 教授
- 学位
- 医学博士(自治医科大学)
- 研究者番号
- 80544303
- ORCID ID
https://orcid.org/0000-0003-1652-9438
- J-GLOBAL ID
- 201401003507762210
- researchmap会員ID
- B000237574
研究分野
1学歴
2-
2010年4月 - 2014年3月
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1994年4月 - 2000年3月
受賞
6-
2013年4月
論文
268-
Acta obstetricia et gynecologica Scandinavica 98(6) 813-813 2019年1月 査読有り
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The journal of obstetrics and gynaecology research 45(5) 1071-1075 2019年1月 査読有り責任著者
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European Journal of Obstetrics & Gynecology and Reproductive Biology 232 82-86 2019年1月 査読有り
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Archives of gynecology and obstetrics 299(2) 593-594 2018年12月 査読有り
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Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 39(4) 1 2018年12月 査読有り
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JOURNAL OF REPRODUCTIVE IMMUNOLOGY 130 41 2018年11月 査読有り
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American Journal of Obstetrics and Gynecology 219(5) 515-516 2018年11月 査読有り
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JOURNAL OF REPRODUCTIVE IMMUNOLOGY 130 41 2018年11月
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JOURNAL OF REPRODUCTIVE IMMUNOLOGY 130 31-32 2018年11月 査読有り
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HYPERTENSION RESEARCH IN PREGNANCY 6(2) 73-75 2018年11月 査読有り筆頭著者責任著者
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International heart journal 60(1) 100-107 2018年11月 査読有り
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AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY 58(5) E14-E15 2018年10月 査読有り筆頭著者責任著者
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AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY 58(5) E14-E15 2018年10月 査読有り筆頭著者責任著者
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Pregnancy Hypertension 14 174-176 2018年10月 査読有り
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PLACENTA 69 E90-E90 2018年9月 査読有り
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PLACENTA 69 E82 2018年9月 査読有り
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Archives of gynecology and obstetrics 298(3) 459-460 2018年9月 査読有り
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International journal of molecular sciences 19(8) 2018年8月 査読有り
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The journal of obstetrics and gynaecology research 45(1) 96-103 2018年8月 査読有り
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The journal of obstetrics and gynaecology research 44(8) 1499-1500 2018年8月 査読有り
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The journal of obstetrics and gynaecology research 44(10) 2016-2017 2018年7月 査読有り
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Archives of Gynecology and Obstetrics 298(2) 1-2 2018年6月22日 査読有り
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Chinese Medical Journal 131(12) 1504-1505 2018年6月20日 査読有り
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Archives of Gynecology and Obstetrics 298(2) 1-2 2018年6月18日 査読有り
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Case Reports in Obstetrics and Gynecology 2018 6591025 2018年6月13日 査読有り責任著者
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The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 33(1) 1-131 2018年6月 査読有り
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Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 38(8) 1 2018年6月 査読有り
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BJOG: An International Journal of Obstetrics and Gynaecology 125(7) 905-906 2018年6月1日 査読有り
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American Journal of Reproductive Immunology 79(6) e12826 2018年6月1日 査読有りProblem: We investigated the effect of oxygen concentrations on cellular senescence and autophagy and examined the role of autophagy in human trophoblast cells. Method of study: Human first-trimester trophoblast cells (Sw.71) were incubated under 21%, 5%, or 1% O2 concentrations for 24 hours. We examined the extent of senescence caused using senescence-associated β-galactosidase (SA-β-Gal) and senescence-associated secretory phenotype (SASP) as markers. Moreover, we examined the role of autophagy in causing cellular senescence using an autophagy inhibitor (3-methyladenine, 3MA). Results: Physiological normoxia (5% O2) decreased SA-β-Gal-positive cells and SASP including interleukin-6 (IL-6) and IL-8 compared with cultured cells in 21% O2. Pathophysiological hypoxia (1% O2) caused cytotoxicity, including extracellular release of ATP and lactate dehydrogenase, and decreased senescence phenotypes. 3MA-treated trophoblast cells significantly suppressed senescence markers (SA-β-Gal-positive cells and SASP secretion) in O2-independent manner. Conclusion: We conclude that O2 concentration modulates cellular senescence phenotypes regulating autophagy in the human trophoblast cells. Moreover, inhibiting autophagy suppresses cellular senescence, suggesting that autophagy contributes to oxygen stress-induced cellular senescence.
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Journal of Obstetrics and Gynaecology Research 44(6) 1186-1187 2018年6月1日 査読有り
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Journal of Maternal-Fetal and Neonatal Medicine 31(10) 1390-1391 2018年5月19日 査読有り
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The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1-2 2018年5月 査読有り
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American journal of obstetrics and gynecology 219(3) 312-313 2018年5月 査読有り
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Pediatric Allergy and Immunology 29(3) 332-333 2018年5月1日 査読有り
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The journal of obstetrics and gynaecology research 2018年4月 査読有り
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International Journal of Gynecology and Obstetrics 140(3) 357-364 2018年3月1日 査読有り筆頭著者責任著者Objective: To determine the efficacy and safety of the Matsubara–Takahashi cervix-holding technique (MT-holding) for achieving hemostasis for postpartum hemorrhage (PPH). Methods: The present retrospective observational study included data from deliveries that occurred between January 1, 2004, and December 31, 2014, at the Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Japan. Deliveries were included where patients experienced blood loss greater than 2500 mL and MT-holding was used. The success rates of the technique in patients with placenta accreta spectrum (PAS) disorders and PPH were determined subsequent pregnancy outcomes were also examined. Results: There were 53 deliveries included in the study 29 patients had placenta previa and 8 of these patients also had PAS disorders. MT-holding achieved hemostasis in 15 (71%) and 4 (50%) patients with placenta previa without and with PAS disorders, respectively the placenta was removed in the latter. Overall, MT-holding achieved hemostasis in 40 (75%) deliveries. Of nine patients who became pregnant after this procedure, six went on to have full-term deliveries. Conclusion: MT-holding achieved hemostasis in 50% of patients with PAS disorders and had an overall success rate of 75% for PPH, comparable to other uterus-sparing procedures. MT-holding is suggested as a simple, effective, safe technique available to less-experienced obstetrician these findings require confirmation in larger studies.
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Journal of Maternal-Fetal and Neonatal Medicine 31(2) 251-252 2018年1月17日 査読有り
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Journal of Obstetrics and Gynaecology 38(1) 146-147 2018年1月2日 査読有り
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Clinical and Experimental Obstetrics and Gynecology 45(1) 72-74 2018年 査読有りUterine artery pseudoaneurysm (UAP), an important cause of postabortal or postpartum hemorrhage, usually accompanies a preceding event, which injures the arterial wall, leading to pseudoaneurysm formation. The authors here propose a new concept, UAP without preceding events. Simultaneous occurrence of UAP and cesarean scar pregnancy may well illustrate the situation.
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Case Reports in Obstetrics and Gynecology 2018 2158248 2018年 査読有り
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Archives of Gynecology and Obstetrics 297(1) 269-270 2018年1月1日 査読有り
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Archives of Gynecology and Obstetrics 297(1) 1-2 2018年1月1日 査読有りIntroduction: Intentional placental removal for abnormally invasive placenta (AIP) is fundamentally abandoned at planned surgery for it. Whether this holds true even after recent introduction of various hemostatic procedures is unclear. Materials and Methods: We discussed on this issue based on our own experiences and also on the recent reports on various hemostatic procedures. Results: Studies directly answering this question have been lacking. We must weigh the balance between the massive bleeding and possibility of uterus-preservation when intentional placental removal strategy is employed. Conclusion: An almost forgotten strategy, the “intentional placental removal” for planned AIP surgery may regain its position when appropriate hemostatic procedures are concomitantly used depending on the situation. Even employing this strategy, quick decision to perform hysterectomy under multidisciplinary team may be important.
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The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 1-2 2018年1月 査読有り
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Hypertension Research 41(1) 45-52 2018年 査読有りOur aim was to evaluate whether the serum level of galectin-1 (Gal-1) at 18-24 and 27-31 weeks of gestation is a risk factor for predicting the later occurrence of not only preeclampsia (PE) but also gestational hypertension (GH). We measured serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and Gal-1 using an enzyme-linked immunosorbent assay in 81 and 73 normal pregnant women, 22 and 16 women with a later onset of GH, and 37 and 29 women with a later onset of PE at 18-24 and 27-31 weeks, respectively. We also measured Gal-1 in 33 women with GH and 78 women with PE after the onset. The levels of Gal-1 after the onset of GH, late-onset PE (onset at ≫34 weeks), and earlyonset PE (onset at o34 weeks) were significantly higher than those in normal pregnant women at 27-31 weeks. However, the low levels of Gal-1 (o8.1 ng ml-1) at 18-24 weeks, but not at 27-31 weeks, predicted the later occurrence of not only earlyonset PE and late-onset PE but also GH. The low level of Gal-1 at 18-24 weeks was an independent risk factor for the later occurrence of GH and PE, after adjusting for the effects of a high BP and increased sFlt-1/PlGF ratio at 18-24 weeks. In conclusion, the serum level of Gal-1 is a novel risk factor for both GH and PE, specifically its expression at a low level in the second trimester and a high level after onset.
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JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 43(12) 1890-1891 2017年12月 査読有り
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JOURNAL OF REPRODUCTIVE IMMUNOLOGY 124 82-82 2017年11月 査読有り
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PLACENTA 59 179-180 2017年11月
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JOURNAL OF REPRODUCTIVE IMMUNOLOGY 124 73-73 2017年11月 査読有り
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HYPERTENSION RESEARCH IN PREGNANCY 5(2) 59-64 2017年11月 査読有り筆頭著者責任著者
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ARCHIVES OF GYNECOLOGY AND OBSTETRICS 296(5) 851-853 2017年11月 査読有りBackground At cesarean hysterectomy for abnormally invasive placenta, rupture of aberrant vessels around the uterus causes massive bleeding. Purpose This study aimed at describing a technique to reduce bleeding from aberrant vessels at the posterior bladder wall in this surgery. Methods The bladder is filled with 200-300 mL of water during handling the posterior bladder wall. Results This technique facilitates understanding that some aberrant vessels do not have communications with the cervix-uterus. Some aberrant vessels have communication with the cervix-uterus and this technique makes cutting and ligation of these vessels easy. Conclusions Filling the bladder may reduce bleeding from the posterior bladder wall at cesarean hysterectomy for abnormally invasive placenta.
MISC
361-
PLACENTA 128 131-132 2022年10月
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産婦人科の実際 70(4) 433-438 2021年4月<文献概要>胎児頸部嚢胞性ヒグローマ(CH)が認められると児疾患が増加する。一方,CHが認められても,それが軽快する際は予後良好であることも多い。しかし,CH軽快例が出生後長期にわたり追跡された研究はほとんどない。今回,妊娠11週0日〜13週6日に当院でCHと診断された症例の児予後を出生後も追跡調査した。CHを認めた69例中24例(34.8%)において軽快した。CH軽快例のうち追跡不能であった1例を除いた23例中,なんらかの児疾患が認められたのは12例(52.2%)であった。このなかで認められた児疾患は,ダウン症候群などの染色体異常,ヌーナン症候群,心奇形,原因不明の精神発達遅滞など多岐にわたった。CH軽快例に対する患者や家族への説明も慎重に行う必要があることが示唆された。
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栃木県産婦人科医報 47 13-15 2021年3月卵巣静脈血栓症は非常に稀で無症状に経過しその発症に気づかれないことも多い。今回、無症状であったが帝王切開術後に酸素飽和度の低下で判明した卵巣静脈血栓症、肺塞栓症を併発した双胎妊娠例を報告する。妊娠中に無症候性の卵巣静脈血栓症から、肺塞栓症を併発する場合があり、血栓リスクを考慮し、症状がなくともSpO2低下や血栓マーカー異常が認められた場合は、これらの疾患発症を念頭においた検査が必要と考える。(著者抄録)
共同研究・競争的資金等の研究課題
6-
日本学術振興会 科学研究費助成事業 2023年4月 - 2026年3月
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日本学術振興会 科学研究費助成事業 基盤研究(C) 2022年4月 - 2025年3月
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日本学術振興会 科学研究費助成事業 基盤研究(C) 2022年4月 - 2025年3月
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日本学術振興会 科学研究費助成事業 基盤研究(C) 2020年4月 - 2024年3月
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日本学術振興会 科学研究費助成事業 若手研究 2019年4月 - 2022年3月