佐久間 康成

右上葉気管支内腔に限局し, 充満性に発育した腎癌の転移性気道腫瘍に対し右上葉管状切除術を施行した1例を報告する.<BR>症例は, 53歳男性で, 喀血, 腫瘤の喀出を主訴に外来受診した.既往歴では, 8年前に左腎癌にて腎摘出術を行なっていた.<BR>気管支鏡では, 疣贅状の腫瘤が右上幹入口部を完全に閉塞し, 一部主幹に突出していた.喀出した腫瘤の組織診で, 腎癌の転移性気道腫瘍と診断した.全身検索の結果, 局所再発, 多臓器転移を認めず右肺上葉管状切除術, 縦隔リンパ節郭清を施行した.<BR>病理組織では, clear cell carcinomaが右B¹, B²の気管支内腔に限局し, 充満するように発育していた.術後5年再発徴候は認められない.<BR>転移性気道腫瘍としては, 腎癌は多く報告されているが本例の如く, 肺実質内への侵襲がなく気道内腔に広汎に発育した特異な転移形式を認めた症例は珍しく文献的考察を加え報告する.

The purpose of this study is to evaluate green fluorescent protein (GFP) transgenic rats for use as a tool for organ transplantation research. The GFP gene construct was designed to express ubiquitously. By flow cytometry, the cells obtained from the bone marrow, spleen, and peripheral blood of the GFP transgenic rats consisted of 77, 91, and 75% GFP-positive cells, respectively. To examine cell migration of GFP-positive cells after organ transplantation, pancreas graft with or without spleen transplantation, heart graft with or without lung transplantation, auxiliary liver and small bowel transplantation were also performed from GFP transgenic rat to LEW (RT11) rats under a 2-week course of 0.64 mg/kg tacrolimus administration. GFP-positive donor cells were detected in the fully allogenic LEW rats after organ transplantation. These results showed that GFP transgenic rat is a useful tool for organ transplantation research such as cell migration study after organ transplantation without donor cell staining. © 2001 Academic Press.