A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors

Masanori Nakakuki, Hitoshi Shimano, Noriyuki Inoue, Mariko Tamura, Takashi Matsuzaka, Yoshimi Nakagawa, Naoya Yahagi, Hideo Toyoshima, Ryuichiro Sato, Nobuhiro Yamada

FEBS JOURNAL 274(17) 4440-4452 2007年9月査読有り
SREBP-1-independent regulation of lipogenic gene expression in adipocytes

Motohiro Sekiya, Naoya Yahagi, Takashi Matsuzaka, Yoshinori Takeuchi, Yoshimi Nakagawa, Haruka Takahashi, Hiroaki Okazaki, Yoko Iizuka, Ken Ohashi, Takanari Gotoda, Shun Ishibashi, Ryozo Nagai, Tsutomu Yamazaki, Takashi Kadowaki, Nobuhiro Yamada, Jun-ichi Osuga, Hitoshi Shimano

JOURNAL OF LIPID RESEARCH 48(7) 1581-1591 2007年7月査読有り
Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver

Takashi Yamamoto, Hitoshi Shimano, Noriyuki Inoue, Yoshimi Nakagawa, Takashi Matsuzaka, Akimitsu Takahashi, Naoya Yahagi, Hirohito Sone, Hiroaki Suzuki, Hideo Toyoshima, Nobuhiro Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 282(16) 11687-11695 2007年4月査読有り
Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

Hiroaki Okazaki, Fumiko Tazoe, Sachiko Okazaki, Naoyuki Isoo, Kazuhisa Tsukamoto, Motohiro Sekiya, Naoya Yahagi, Yoko Iizuka, Ken Ohashi, Tetsuya Kitamine, Ryu-ichi Tozawa, Toshihiro Inaba, Hiroaki Yagyu, Mitsuyo Okazaki, Hitoshi Shimano, Norihito Shibata, Hiroyuki Arai, Ryo-zo Nagai, Takashi Kadowaki, Jun-ichi Osuga, Shun Ishibashi

JOURNAL OF LIPID RESEARCH 47(9) 1950-1958 2006年9月査読有り
Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

Toyonori Kato, Hitoshi Shimano, Takashi Yamamoto, Tomotaka Yokoo, Yuko Endo, Mayumi Ishikawa, Takashi Matsuzaka, Yoshimi Nakagawa, Shin Kumadaki, Naoya Yahagi, Akimitsu Takahashi, Hirohito Sone, Hiroaki Suzuki, Hideo Toyoshima, Alyssa H. Hasty, Satoru Takahashi, Hiroshi Gomi, Tetsuro Izumi, Nobuhiro Yamada

CELL METABOLISM 4(2) 143-154 2006年8月査読有り
Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol - A potential role in adipocyte lipolysis

H Okazaki, M Igarashi, M Nishi, M Tajima, M Sekiya, S Okazaki, N Yahagi, K Ohashi, K Tsukamoto, M Amemiya-Kudo, T Matsuzaka, H Shimano, N Yamada, J Aoki, R Morikawa, Y Takanezawa, H Arai, R Nagai, T Kadowaki, J Osuga, S Ishibashi

DIABETES 55(7) 2091-2097 2006年7月査読有り
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

Y Nakagawa, H Shimano, T Yoshikawa, T Ide, M Tamura, M Furusawa, T Yamamoto, N Inoue, T Matsuzaka, A Takahashi, AH Hasty, H Suzuki, H Sone, H Toyoshima, N Yahagi, N Yamada

NATURE MEDICINE 12(1) 107-113 2006年1月査読有り
Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47

M Amemiya-Kudo, J Oka, T Ide, T Matsuzaka, H Sone, T Yoshikawa, N Yahagi, S Ishibashi, J Osuga, N Yamada, T Murase, H Shimano

JOURNAL OF BIOLOGICAL CHEMISTRY 280(41) 34577-34589 2005年10月査読有り
Lipid synthetic transcription factor SREBP-1a activates p21(WAF1/CIP1), a universal cyclin-dependent kinase inhibitor

N Inoue, H Shimano, M Nakakuki, T Matsuzaka, Y Nakagawa, T Yamamoto, R Sato, A Takahashi, H Sone, N Yahagi, H Suzuki, H Toyoshima, N Yamada

MOLECULAR AND CELLULAR BIOLOGY 25(20) 8938-8947 2005年10月査読有り
SREBPs activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.

Amemiya-Kudo,M, Oka,J, Ide,T, Matsuzaka,T, Sone,H, Yoshikawa,T, Yahagi,N, Ishibashi,S, Osuga,JI, Yamada,N, Murase,T, Shimano,H

J Biol Chem 280(41) 34577-89 2005年10月査読有り
High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding

Y Najima, N Yahagi, Y Takeuchi, T Matsuzaka, M Sekiya, Y Nakagawa, M Amemiya-Kudo, H Okazaki, S Okazaki, Y Tamura, Y Iizuka, K Ohashi, K Harada, T Gotoda, R Nagai, T Kadowaki, S Ishibashi, N Yamada, J Osuga, H Shimano

JOURNAL OF BIOLOGICAL CHEMISTRY 280(30) 27523-27532 2005年7月査読有り
Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma

N Yahagi, H Shimano, K Hasegawa, K Ohashi, T Matsuzaka, Y Najima, M Sekiya, S Tomita, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, R Nagai, S Ishibashi, T Kadowaki, M Makuuchi, S Ohnishi, J Osuga, N Yamada

EUROPEAN JOURNAL OF CANCER 41(9) 1316-1322 2005年6月査読有り筆頭著者
Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells

A Takahashi, K Motomura, T Kato, T Yoshikawa, Y Nakagawa, N Yahagi, H Sone, H Suzuki, H Toyoshima, N Yamada, H Shimano

DIABETES 54(2) 492-499 2005年2月査読有り
Microarray analyses of SREBP-1 target genes.

Yahagi, N, Shimano, H

In Berger A and Roberts MA (ed.), Unraveling Lipid Metabolism with Microarrays 237-248 2005年1月査読有り筆頭著者
Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide

Y Tamura, J Osuga, H Adachi, R Tozawa, Y Takanezawa, K Ohashi, N Yahagi, M Sekiya, H Okazaki, S Tomita, Y Iizuka, H Koizumi, T Inaba, H Yagyu, N Kamada, H Suzuki, H Shimano, T Kadowaki, M Tsujimoto, H Arai, N Yamada, S Ishibashi

JOURNAL OF BIOLOGICAL CHEMISTRY 279(30) 30938-30944 2004年7月査読有り
P53 involvement in the pathogenesis of fatty liver disease

N Yahagi, H Shimano, T Matsuzaka, M Sekiya, Y Najima, S Okazaki, H Okazaki, Y Tamura, Y Iizuka, N Inoue, Y Nakagawa, Y Takeuchi, K Ohashi, K Harada, T Gotoda, R Nagai, T Kadowaki, S Ishibashi, J Osuga, N Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 279(20) 20571-20575 2004年5月査読有り筆頭著者
Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep(ob/ob) mice

M Sekiya, JI Osuga, H Okazaki, N Yahagi, K Harada, WJ Shen, Y Tamura, S Tomita, Y Iizuka, K Ohashi, M Okazaki, M Sata, R Nagai, T Fujita, H Shimano, FB Kraemer, N Yamada, S Ishibashi

JOURNAL OF BIOLOGICAL CHEMISTRY 279(15) 15084-15090 2004年4月査読有り
SREBPs suppress IRS-2-mediated insulin signalling in the liver

T Ide, H Shimano, N Yahagi, T Matsuzaka, M Nakakuki, T Yamamoto, Y Nakagawa, A Takahashi, H Suzuki, H Sone, H Toyoshima, A Fukamizu, N Yamada

NATURE CELL BIOLOGY 6(4) 351-357 2004年4月査読有り
SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes

T Yamamoto, H Shimano, Y Nakagawa, T Ide, N Yahagi, T Matsuzaka, M Nakakuki, A Takahashi, H Suzuki, H Sone, H Toyoshima, R Sato, N Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 279(13) 12027-12035 2004年3月査読有り
Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

T Matsuzaka, H Shimano, N Yahagi, M Amemiya-Kudo, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, S Tomita, M Sekiya, A Hasty, Y Nakagawa, H Sone, H Toyoshima, S Ishibashi, J Osuga, N Yamada

DIABETES 53(3) 560-569 2004年3月査読有り
Hepatic akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement

H Ono, H Shimano, H Katagiri, N Yahagi, H Sakoda, Y Onishi, M Anai, T Ogihara, M Fujishiro, AYI Viana, Y Fukushima, M Abe, N Shojima, M Kikuchi, N Yamada, Y Oka, T Asano

DIABETES 52(12) 2905-2913 2003年12月査読有り
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression

M Sekiya, N Yahagi, T Matsuzaka, Y Najima, M Nakakuki, R Nagai, S Ishibashi, J Osuga, N Yamada, H Shimano

HEPATOLOGY 38(6) 1529-1539 2003年12月査読有り
Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

K Ohashi, J Osuga, R Tozawa, T Kitamine, H Yagyu, M Sekiya, S Tomita, H Okazaki, Y Tamura, N Yahagi, Y Iizuka, K Harada, T Gotoda, H Shimano, N Yamada, S Ishibashi

JOURNAL OF BIOLOGICAL CHEMISTRY 278(44) 42936-42941 2003年10月査読有り
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling

T Yoshikawa, T Ide, H Shimano, N Yahagi, M Amemiya-Kudo, T Matsuzaka, S Yatoh, T Kitamine, H Okazaki, Y Tamura, M Sekiya, A Takahashi, AH Hasty, R Sato, H Sone, JI Osuga, S Ishibashi, N Yamada

MOLECULAR ENDOCRINOLOGY 17(7) 1240-1254 2003年7月査読有り
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

T Ide, H Shimano, T Yoshikawa, N Yahagi, M Amemiya-Kudo, T Matsuzaka, M Nakakuki, S Yatoh, Y Iizuka, S Tomita, K Ohashi, A Takahashi, H Sone, T Gotoda, JI Osuga, S Ishibashi, N Yamada

MOLECULAR ENDOCRINOLOGY 17(7) 1255-1267 2003年7月査読有り
P53 activation in adipocytes of obese mice

N Yahagi, H Shimano, T Matsuzaka, Y Najima, M Sekiya, Y Nakagawa, T Ide, S Tomita, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, T Gotoda, R Nagai, S Kimura, S Ishibashi, J Osuga, N Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 278(28) 25395-25400 2003年7月査読有り筆頭著者
FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products

Y Tamura, H Adachi, J Osuga, K Ohashi, N Yahagi, M Sekiya, H Okazaki, S Tomita, Y Iizuka, H Shimano, R Nagai, S Kimura, M Tsujimoto, S Ishibashi

JOURNAL OF BIOLOGICAL CHEMISTRY 278(15) 12613-12617 2003年4月査読有り
Lipolysis in the absence of hormone-sensitive lipase - Evidence for a common mechanism regulating distinct lipases

H Okazaki, J Osuga, Y Tamura, N Yahagi, S Tomita, F Shionoiri, Y Iizuka, K Ohashi, K Harada, S Kimura, T Gotoda, H Shimano, N Yamada, S Ishibashi

DIABETES 51(12) 3368-3375 2002年12月査読有り
Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase

H Okazaki, JI Osuga, K Tsukamoto, N Isoo, T Kitamine, Y Tamura, S Tomita, M Sekiya, N Yahagi, Y Iizuka, K Ohashi, K Harada, T Gotoda, H Shimano, S Kimura, R Nagai, N Yamada, S Ishibashi

JOURNAL OF BIOLOGICAL CHEMISTRY 277(35) 31893-31899 2002年8月査読有り
Transcriptional activities of nuclear SREBP-1a,-1c, and-2 to different target promoters of lipogenic and cholesterogenic genes

M Amemiya-Kudo, H Shimano, AH Hasty, N Yahagi, T Yoshikawa, T Matsuzaka, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, J Osuga, K Harada, T Gotoda, R Sato, S Kimura, S Ishibashi, N Yamada

JOURNAL OF LIPID RESEARCH 43(8) 1220-1235 2002年8月査読有り
A kindred of familial acromegaly without evidence for linkage to MEN-1 locus

Y Tamura, S Ishibashi, T Gotoda, J Yasufuku-Takano, K Takano, K Ueki, S Yamashita, Y Iizuka, N Yahagi, F Shionoiri, H Okazaki, K Ohashi, J Osuga, K Harada, H Shimano, T Fujita, N Yamada, S Kimura

ENDOCRINE JOURNAL 49(4) 425-431 2002年8月査読有り
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs

T Matsuzaka, H Shimano, N Yahagi, T Yoshikawa, M Amemiya-Kudo, AH Hasty, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, J Osuga, A Takahashi, S Yato, H Sone, S Ishibashi, N Yamada

JOURNAL OF LIPID RESEARCH 43(6) 911-920 2002年6月査読有り
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice

N Yahagi, H Shimano, AH Hasty, T Matsuzaka, T Ide, T Yoshikawa, M Amemiya-Kudo, S Tomita, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, J Osuga, K Harada, T Gotoda, R Nagai, S Ishibashi, N Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 277(22) 19353-19357 2002年5月査読有り筆頭著者
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

T Yoshikawa, H Shimano, N Yahagi, T Ide, M Amemiya-Kudo, T Matsuzaka, M Nakakuki, S Tomita, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, A Takahashi, H Sone, J Osuga, T Gotoda, S Ishibashi, N Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 277(3) 1705-1711 2002年1月査読有り
Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status

H Sone, H Shimano, Y Sakakura, N Inoue, M Amemiya-Kudo, N Yahagi, M Osawa, H Suzuki, T Yokoo, A Takahashi, K Iida, H Toyoshima, A Iwama, N Yamada

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 282(1) E222-E230 2002年1月査読有り
Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPAR alpha

T Matsuzaka, H Shimano, N Yahagi, M Amemiya-Kudo, T Yoshikawa, AH Hasty, Y Tamura, J Osuga, H Okazaki, Y Iizuka, A Takahashi, H Sone, T Gotoda, S Ishibashi, N Yamada

JOURNAL OF LIPID RESEARCH 43(1) 107-114 2002年1月査読有り
Do sex steroids regulate glutamine synthesis with age?

H. Sone, H. Shimano, Y. Sakakura, N. Inoue, M. Amemiya-Kudo, N. Yahagi, M. Osawa, H. Suzuki, T. Yokoo, A. Takahashi, K. Iida, H. Toyoshima, A. Iwama, N. Yamada

American Journal of Physiology - Endocrinology and Metabolism 282(1 45-1) E215-E221 2002年査読有り
Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor

AH Hasty, H Shimano, J Osuga, Namatame, I, A Takahashi, N Yahagi, S Perrey, Y Iizuka, Y Tamura, M Amemiya-Kudo, T Yoshikawa, H Okazaki, K Ohashi, K Harada, T Matsuzaka, H Sone, T Gotoda, R Nagai, S Ishibashi, N Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 276(40) 37402-37408 2001年10月査読有り
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

T Yoshikawa, H Shimano, M Amemiya-Kudo, N Yahagi, AH Hasty, T Matsuzaka, K Okazaki, Y Tamura, Y Iizuka, K Ohashi, JI Osuga, K Harada, T Gotoda, S Kimura, S Ishibashi, N Yamada

MOLECULAR AND CELLULAR BIOLOGY 21(9) 2991-3000 2001年5月査読有り
Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit - Its obligate requirement for the stable expression of oligomeric receptor

R Tozawa, S Ishibashi, J Osuga, K Yamamoto, H Yagyu, K Ohashi, Y Tamura, N Yahagi, Y Iizuka, H Okazaki, K Harada, T Gotoda, H Shimano, S Kimura, R Nagai, N Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 276(16) 12624-12628 2001年4月査読有り
Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice - Pleiotropic effects on CD36 expression and HDL

Z Chen, S Ishibashi, S Perrey, J Osuga, T Gotoda, T Kitamine, Y Tamura, H Okazaki, N Yahagi, Y Iizuka, F Shionoiri, K Ohashi, K Harada, H Shimano, R Nagai, N Yamada

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 21(3) 372-377 2001年3月査読有り
Thiazolidinedione- and tumor necrosis factor alpha-induced downregulation of peroxisome proliferator-activated receptor gamma mRNA in differentiated 3T3-L1 adipocytes

S Perrey, S Ishibashi, N Yahagi, J Osuga, R Tozawa, H Yagyu, K Ohashi, T Gotoda, K Harada, Z Chen, Y Iizuka, F Shionoiri, N Yamada

METABOLISM-CLINICAL AND EXPERIMENTAL 50(1) 36-40 2001年1月査読有り
The LDL receptor is the major pathway for β-VLDL uptake by mouse peritoneal macrophages

Perrey S, Ishibashi S, Kitamine T, Osuga J.-I, Yagyu H, Chen Z, Shionoiri F, Iizuka Y, Yahagi N, Tamura Y, Ohashi K, Harada K, Gotoda T, Yamada N

Atherosclerosis 154(1) 51-60 2001年1月査読有り
Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level

AH Hasty, H Shimano, N Yahagi, M Amemiya-Kudo, S Perrey, T Yoshikawa, J Osuga, H Okazaki, Y Tamura, Y Iizuka, F Shionoiri, K Ohashi, K Harada, T Gotoda, R Nagai, S Ishibashi, N Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 275(40) 31069-31077 2000年10月査読有り
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene

M Amemiya-Kudo, H Shimano, T Yoshikawa, N Yahagi, AH Hasty, H Okazaki, Y Tamura, F Shionoiri, Y Iizuka, K Ohashi, J Osuga, K Harada, T Gotoda, R Sato, S Kimura, S Ishibashi, N Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 275(40) 31078-31085 2000年10月査読有り
Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia

K Ohashi, S Ishibashi, J Osuga, R Tozawa, K Harada, N Yahagi, F Shionoiri, Y Iizuka, Y Tamura, R Nagai, DR Illingworth, T Gotoda, N Yamada

JOURNAL OF LIPID RESEARCH 41(8) 1199-1204 2000年8月査読有り
Diversity of voltage-gated sodium channels in the ascidian larval nervous system

H Nagahora, T Okada, N Yahagi, JA Chong, G Mandel, Y Okamura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 275(2) 558-564 2000年8月査読有り
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia

H Yagyu, T Kitamine, J Osuga, R Tozawa, Z Chen, Y Kaji, T Oka, S Perrey, Y Tamura, K Ohashi, H Okazaki, N Yahagi, F Shionoiri, Y Iizuka, K Harada, H Shimano, H Yamashita, T Gotoda, N Yamada, S Ishibashi

JOURNAL OF BIOLOGICAL CHEMISTRY 275(28) 21324-21330 2000年7月査読有り
Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity

J Osuga, S Ishibashi, T Oka, H Yagyu, R Tozawa, A Fujimoto, F Shionoiri, N Yahagi, FB Kraemer, O Tsutsumi, N Yamada

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(2) 787-792 2000年1月査読有り
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

H Shimano, N Yahagi, M Amemiya-Kudo, AH Hasty, J Osuga, Y Tamura, F Shionoiri, Y Iizuka, K Ohashi, K Harada, T Gotoda, S Ishibashi, N Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 274(50) 35832-35839 1999年12月査読有り

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