附属さいたま医療センター 外科系診療部

佐瀬 美和子

Sase Miwako

基本情報

所属
自治医科大学 附属さいたま医療センター外科系診療部歯科口腔外科

J-GLOBAL ID
201401011277076187
researchmap会員ID
B000238699

論文

 16
  • Taku Sato, Miwako Sase, Shun Ishikawa, Mihoko Kajita, Jumpei Asano, Toshiro Sato, Yoshiyuki Mori, Toshiaki Ohteki
    Scientific reports 10(1) 8308-8308 2020年5月22日  
    The small intestine has a robust regenerative capacity, and various cell types serve as "cells-of-origin" in the epithelial regeneration process after injury. However, how much each population contributes to regeneration remains unclear. Using lineage tracing, we found that Lgr5-expressing cell derivatives contained radioresistant intestinal stem cells (ISCs) crucial for epithelial regeneration in the damaged intestine after irradiation. Single-cell qRT-PCR analysis showed that surviving Lgr5-expressing cell derivatives in the damaged intestine are remarkably heterogeneous, and that the expression levels of a YAP-target gene Sca1 were inversely correlated with their "stemness", suggesting that the YAP/Wnt signal balance in surviving crypt epithelial cells determines the cellular contribution to epithelial regeneration. Single-cell RNA sequencing of Sca1-Lgr5-derivatives revealed that expression of a tetraspanin family member CD81 correlated well with the expression of ISC- and proliferation-related genes. Consistent with these findings, organoid-forming ability was confined to the CD81hiSca1- fraction within the damaged crypt epithelial cells. Characterization of radioresistant epithelial stem cell heterogeneity in the damaged intestine may contribute to therapeutic strategies for gastrointestinal diseases.
  • 佐瀬美和子, 佐瀬美和子, 浅井昌大, 神部芳則, 森良之
    日本口腔外科学会雑誌 64(6) 361‐366 2018年6月20日  
  • Sase Miwako, Itoh Hiroto, Nakano Takahumi, Hayasaka Junichi, Noguchi Tadahide, Jinbu Yoshinori, Mori Yoshiyuki
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 29(5) 438-442 2017年9月1日  査読有り
    Ghost cell odontogenic carcinoma (GCOC) is a rare malignant odontogenic tumor with aggressive growth characteristics. We report a case of GCOC of the maxilla in a 65-year-old Japanese man who was referred to our hospital with painful swelling of the left maxilla. Computed tomography showed a bone defect in the left upper jaw and the border with the surrounding tissue was indistinct in one area. Tumor resection was performed under general anesthesia, and the histopathological diagnosis was dentinogenic ghost cell tumor (DGCT). Ten months postoperatively, the tumor recurred in the same area, and partial resection of the maxilla was performed. Twelve months after reoperation, the tumor recurred a second time. The histopathological diagnosis this time was GCOC, as a secondary malignant manifestation of the benign DGCT.
  • Takafumi Nakano, Yoshinori Jinbu, Naruo Okada, Miwako Sase, Junichi Hayasaka, Yoshiyuki Tsuchiya, Hiroto Itoh, Tadahide Noguchi, Kentaro Hoshi, Yoshiyuki Mori
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 28(6) 525-529 2016年11月1日  査読有り
    We report a very rare case of systemic amyloidosis occurring in bilateral mandibular condyles and showing condylar bone destruction and lesions in the buccal mucosa bilaterally. The patient was a 61-year-old man complaining of malocclusion in which the lower teeth extended abnormally over the upper teeth. He first noticed this about 1 year earlier. Medical history included renal cancer, rheumatic myalgia in multiple joints, osteoporosis, hypothyroidism, chronic hepatitis, malignant lymphoma and hemodialysis for renal failure. Panoramic radiography and computed tomography showed bone destruction in bilateral mandibular condyles and a soft tissue mass lesion around the condyle. Slightly raised mass lesions with areas of whitish and purplish coloration were also observed on the buccal mucosa bilaterally. Histopathological examination revealed amyloid deposition in these lesions, and AA and/or Aβ2M amyloidosis was diagnosed. However, we were informed that the patient died within 3 months from when he had a last check-up at our clinic due to systemic problems.
  • Miwako Sase, Hiroto Itoh, Junichi Hayasaka, Kentaro Hoshi, Tadahide Noguchi, Yoshinori Jinbu, Yoshiyuki Mori
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 28(6) 493-497 2016年11月1日  査読有り
    Small cell carcinoma in the oral and maxillofacial region is an extremely rare, high-grade malignancy. We report a case of small cell carcinoma in the palatal mucosa. An 80-year-old man was referred to our clinic with swelling in the right maxilla. An 80-mm lymph node was seen in the right neck. The clinical diagnosis was malignant tumor of the palatal mucosa and biopsy was performed. The histopathological diagnosis was small cell carcinoma. Systemic examination diagnosed cervical lymph node metastasis, liver metastasis and multiple bone metastases. Considering the clinical stage and performance status, best supportive care was selected. The patient died of multiple-organ failure 3 months after the first visit.

MISC

 6

共同研究・競争的資金等の研究課題

 2