小谷 和彦

OBJECTIVE: Oxidative stress is considered to increase fracture risk, and lipid oxidation can adversely affect bone health. 4-hydroxynonenal (4-HNE) is a representative marker of lipid oxidation. METHODS: We investigated the association between 4-HNE and fracture risk in community-dwelling older subjects (n=78, mean age=78 years). Serum albumin, C-reactive protein, and 4-HNE values were examined with the Fracture Risk Assessment Tool (FRAX®). The FRAX® score of >15% was defined as a high fracture risk. RESULTS: There was a significantly higher 4-HNE value in the group of high fracture risk (n=38, median=12.4 ng/mL) than in the low-risk group (n=40, median=9.8 ng/mL; p=0.02). The correlation of FRAX® major osteoporosis (β=0.45) and FRAX® hip fracture (β=0.44) with 4-HNE was significant after adjustment for multiple variables. CONCLUSIONS: 4-HNE was suggested to be positively associated with fracture risk. This molecule may be a clinical candidate oxidative stress marker for fracture risk in the older population.