基本情報
- 所属
- 自治医科大学 医学部 感染・免疫学講座 細菌学部門 准教授
- 学位
- 博士(工学)(東京大学)
- 研究者番号
- 40323810
- J-GLOBAL ID
- 200901022892347397
- researchmap会員ID
- 1000321728
研究キーワード
3研究分野
1経歴
4-
2022年1月 - 現在
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2007年4月 - 2021年12月
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2000年4月 - 2007年3月
-
1997年4月 - 2000年3月
学歴
2-
- 2000年
-
- 1995年
論文
53-
Corrosion Engineering 51 777-785 2002年 査読有り
MISC
95-
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 84(1) 135-142 2009年8月The susceptibility of mastitis-causing Escherichia coli and Staphylococcus aureus to two commonly used antibiotics, tetracycline and penicillin G, was tested in raw milk and in Muller-Hinton (MH) broth by introducing a pH indicator, bromocresol purple, which was shown to be a simple, sensitive, and rapid method. The minimum inhibitory concentration (MIC) of penicillin G in milk was the same as those in MH broth, whereas the MIC of tetracycline in milk was 4 to 32 times that in MH. An irreversible binding between tetracycline and large molecules of milk, which might be due to a hydrophobic interaction, was demonstrated by a dialysis test, suggesting the observed impairing effect was due to the action of milk on the tetracycline being tested. Further investigation revealed that much of the reduction of tetracycline's activity in milk was attributable to the milk protein casein, while other heat-sensitive components in milk also play some roles.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 84(1) 135-142 2009年8月The susceptibility of mastitis-causing Escherichia coli and Staphylococcus aureus to two commonly used antibiotics, tetracycline and penicillin G, was tested in raw milk and in Muller-Hinton (MH) broth by introducing a pH indicator, bromocresol purple, which was shown to be a simple, sensitive, and rapid method. The minimum inhibitory concentration (MIC) of penicillin G in milk was the same as those in MH broth, whereas the MIC of tetracycline in milk was 4 to 32 times that in MH. An irreversible binding between tetracycline and large molecules of milk, which might be due to a hydrophobic interaction, was demonstrated by a dialysis test, suggesting the observed impairing effect was due to the action of milk on the tetracycline being tested. Further investigation revealed that much of the reduction of tetracycline's activity in milk was attributable to the milk protein casein, while other heat-sensitive components in milk also play some roles.
講演・口頭発表等
2-
4th ASM Conference on Biofilms 2007年
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4th ASM Conference on Biofilms 2007年
所属学協会
7共同研究・競争的資金等の研究課題
18-
日本学術振興会 科学研究費助成事業 2024年4月 - 2029年3月
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日本学術振興会 科学研究費助成事業 2021年7月 - 2024年3月
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日本学術振興会 科学研究費助成事業 2020年4月 - 2023年3月
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日本学術振興会 科学研究費助成事業 2014年4月 - 2017年3月
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日本学術振興会 科学研究費助成事業 2012年4月 - 2017年3月