医学部 総合医学第2講座

草鹿 元

クサカ ゲン  (Gen Kusaka)

基本情報

所属
自治医科大学 医学部 総合医学第2講座  教授

J-GLOBAL ID
201401089608786952
researchmap会員ID
B000239152

外部リンク

論文

 17
  • Kamochi H, Kusaka G, Ishikawa M, Ishikawa S, Tanaka Y
    Neurologia medico-chirurgica 53 217-220 2013年  査読有り
  • Takeharu Kanazawa, Yusuke Watanabe, Mariko Hara, Akihiro Shinnabe, Gen Kusaka, Takanori Murayama, Yukiko Iino
    AMERICAN JOURNAL OF OTOLARYNGOLOGY 33(3) 303-307 2012年5月  査読有り
    Purpose: Laryngeal framework surgery is usually performed under local anesthesia but cannot be tolerated by some patients. To develop a new procedure for these patients, we evaluated voice outcomes after arytenoid adduction combined with medialization laryngoplasty under general anesthesia using a laryngeal mask airway (LMA) for unilateral vocal cord paralysis. Materials and Methods: Eleven consecutive patients with severe unilateral vocal cord paralysis, with a maximum phonation time of less than 5 seconds, underwent arytenoid adduction combined with medialization laryngoplasty under general anesthesia using an LMA. Each paralyzed vocal cord was observed by intraoperative videolaryngoscopy. The vocal cord was moved to the position where the best vocal outcome could be expected, according to 3 parameters obtained from glottal images. Results: All patients achieved a maximum phonation time of more than 11 seconds. The mean airflow rate, which ranged from 550 to 1000 mL/s before surgery, improved to less than 390 mL/s. Perceptual evaluation using the grade, roughness, breathiness, asthenia and strain scale also improved significantly. Conclusions: These results were equivalent to those of previous reports of surgeries performed under local anesthesia. Intraoperative endoscopic vocal cord observation through the LMA may have contributed to the positive results. (C) 2012 Elsevier Inc. All rights reserved.
  • Kanazawa T, Sarukawa S, Fukushima H, Takeoda S, Kusaka G, Ichimura K
    Annals of vascular diseases 4 189-195 2011年  査読有り
  • Mami Ishikawa, Gen Kusaka, Kouichi Takashima, Haruna Kamochi, Soji Shinoda
    JOURNAL OF CLINICAL NEUROSCIENCE 17(8) 1053-1056 2010年8月  査読有り
    A 54-year-old man presented with an intracranial schwannoma of the hypoglossal nerve between the medulla and the left hypoglossal canal. The condylar fossa approach was used with intra-operative electromyography (EMG) monitoring of the lower cranial nerves. The tumor was then removed carefully without decreasing the tongue EMG responses. EMG monitoring enabled us to remove the tumor while maintaining the function of the hypoglossal nerve. Tongue EMG was easily recorded by stimulating the hypoglossal nerve fibers, which was useful in identifying the hypoglossal nerve and evaluating its function. This suggests that tongue EMG is a useful monitoring tool to enhance neurological outcome following removal of tumors in this region. (C) 2009 Elsevier Ltd. All rights reserved.
  • Mami Ishikawa, Koichi Takashima, Haruna Kamochi, Gen Kusaka, Sohji Shinoda, Eiju Watanabe
    NEUROLOGICAL RESEARCH 32(6) 656-660 2010年7月  査読有り
    Botulinum toxin type A (BTX) injection into the orbicularis oculi muscle is an effective treatment for patients with hemifacial spasm (HFS). The objectives of this study were to investigate the effect of this treatment on HFS, in particular the associated hyperexcitability of the facial motor nucleus, and to discuss the potential mechanism of HFS. F waves in the mentalis muscle were examined before, 2 and 6 weeks after the BTX treatment of only the orbicularis oculi muscle in ten patients with HFS. F/M ratio, duration of F waves and frequency of F waves decreased significantly after the BTX treatment compared with those before the BTX treatment. These findings demonstrate that the excitability of the facial motonucleus decreases after BTX treatment of the orbicularis oculi muscle. From these results, we hypothesize that the trigeminal afferent input and the cortical control contribute to the hyperexcitability of the facial motor nucleus in patients with HFS. This warrants further investigation into the pathophysiology of HFS.

MISC

 6
  • 石川 眞実, 草鹿 元, 篠田 宗次, 山口 則之, 渡辺 英寿
    脳卒中の外科 = Surgery for cerebral stroke 37(2) 93-99 2009年3月31日  
    Pathophysiology after subarachnoid hemorrhage (SAH) has not been well examined. We observed platelet-leukocyte-endothelial cell interactions as indexes of inflammatory and prothrombogenic responses in the acute phase of SAH, using an in vivo cranial window method. <br> Subarachnoid hemorrhage was induced in C57Bl/6J mice by the endovascular perforation method. Regional cerebral blood flow (rCBF) was measured with laser-doppler flowmetry. The platelet-leukocyte-endothelial cell interactions were observed with an intravital microscopy 30 minutes, 2 hours, and 8 hours after SAH. The effect of P-selectin antibody and apocynin on these responses was examined, and compared with a different SAH model, in which autologous blood was injected into the foramen magnum. <br> SAH was accompanied by a 60% decrease in rCBF, whereas no changes in rCBF were observed on the contralateral side. SAH elicited time- and size-dependent increases in rolling and adherent platelets and leukocytes in cerebral venules, attenuated by a P-selectin antibody, or apocynin. There was no significant blood cell recruitment in the blood-injected SAH model. <br> SAH at the skull base induced P-selectin- and oxygen radical-mediated platelet-leukocyte-endothelial cell interactions in venules at the cerebral surface. These early inflammatory and prothrombogenic responses may cause a whole brain injury immediately after SAH.<br>
  • 高嶋 浩一, 高橋 真由美, 湯舟 憲雄, 稲葉 信夫, 尾本 きよか, 河野 幹彦, 櫻林 郁之介, 石川 眞実, 草鹿 元, 篠田 宗次
    臨床病理 56(6) 475-485 2008年6月25日  
  • 鈴木 尚, 草鹿 元, 大森 義男, 篠田 宗次
    自治医科大学紀要 29 181-186 2006年12月1日  
    ラトケ嚢胞に伴って発症する下垂体卒中は極めて稀である。今回我々は,ラトケ嚢胞に伴った下垂体卒中の2症例を経験した。症例は次の通りである。症例1:28歳男性で突然の頭痛と嘔気,めまいにて発症。MRIでトルコ鞍内から鞍上部に混合信号域を認め,出血を伴った嚢胞性病変が疑われた。経蝶形骨洞的腫瘍摘出術施行し,術後症状は消失した。症例2:32歳女性。鎮痛剤無効の頭痛のためMRI施行し,同様にトルコ鞍内に出血が疑われたため,経蝶形骨洞的腫瘍摘出術施行した。術後症状は消失し,病理所見はいずれも出血を伴ったラトケ嚢胞であった。下垂体卒中は主に下垂体腺腫に伴って生じることが多く,ラトケ嚢胞に伴った下垂体卒中の報告は,これまで渉猟しえた文献では,本2症例を含め9症例のみであった。ラトケ嚢胞からの出血の機序や治療方法など,我々の経験も含め若干の文献学的考察を加え報告する。
  • 鈴木 尚, 神田 大, 草鹿 元, 大森 義男, 石川 三衛, 篠田 宗次
    日本内分泌学会雑誌 81 164-165 2005年9月20日  
  • 宮脇 貴裕, 草鹿 元, 篠田 宗次, 増澤 紀男
    脳神経外科ジャーナル 10(6) 409-413 2001年  
    悪性リンパ腫が脊髄髄内に原発することはきわめて稀といわれている.われわれは41歳, 男性で, 両下肢の温痛覚障害, 両下肢の筋力低下, 膀胱直腸障害で発症した1例を報告する.MRIを含む画像所見では, Th7〜9に及ぶGd-DTPAにて増強される腫瘍を認め, 脊髄髄内腫瘍の診断で同部位の椎弓切除と生検術を施行した.病理組織所見はB-cell type diffuse large non-Hodgkin malignant lymphomaであった.発症から緩徐な経過をとり, ステロイドが効果のなかったことが診断まで時間を要した原因と思われた稀な脊髄悪性リンパ腫を経験した.