基本情報
研究キーワード
1研究分野
1経歴
1論文
656-
International journal of surgery case reports 23 151-156 2016年 査読有り
-
日本内視鏡外科学会雑誌 20(7) WS16-7 2015年12月
-
The American surgeon 81(12) 1263-1271 2015年12月 査読有り
-
日本臨床外科学会雑誌 76(10) 2493-2498 2015年10月症例は57歳の女性.右下腹部腫瘤の精査で盲腸癌と診断された.術前の腹部超音波検査で肝S2に径10mmの境界明瞭で内部不均一な低エコー腫瘤を認めた.CT検査では淡い低吸収域として認め,造影効果は認めなかった.MRI検査ではT1強調で低信号,T2強調で軽度高信号を示し,superparamagnetic iron oxide(SPIO)造影後T2強調で明瞭な高信号として描出され,拡散強調画像で拡散の低下を認めた.盲腸癌・転移性肝癌と診断し,回盲部切除術と肝部分切除術を施行した.病理組織学的所見で肝reactive lymphoid hyperplasiaと診断された.術後8年再発なく経過している.肝reactive lymphoid hyperplasiaは良性疾患とされているが,術前検査で悪性腫瘍との鑑別が困難であり,外科的切除が行われることが多い.診断,治療の現状と問題点を考察した.(著者抄録)
-
Gastrointestinal endoscopy 83(3) 602-7 2015年9月 査読有り
-
RADIOTHERAPY AND ONCOLOGY 116(2) 209-213 2015年8月 査読有りPurpose: This study was designed to evaluate the safety and efficacy of adding oxaliplatin to preoperative chemoradiotherapy (CRT) with S-1 in patients with locally advanced rectal carcinoma (LARC). Patients and methods: This was a multicenter phase II study in patients with histologically proven clinical stage T3 or T4 (any N, M0) LARC. Patients preoperatively received oral S-1 (80 mg/m(2)/day on days 1-5, 8-12,22-27, and 29-33) and infusional oxaliplatin (60 mg/m(2) days on 1, 8, 22, and 29) plus radiotherapy (50.4 Gy), with a chemotherapy gap in the third week of radiotherapy. Pathological complete response (pCR) was the primary endpoint. Secondary endpoints included toxicity, compliance, R0 resection rate, and downstaging rate. Results: A total of 45 patients were enrolled at six centers in Japan. All 45 patients received CRT, and 44 underwent operation. A pCR was achieved in 12 (27.3%) of the 44 patients who underwent surgery. Near-total tumor regression was confirmed in 47.7%. There were no grade 4 adverse events, and 11.1% of the patients had grade 3 adverse events. R0 resection was achieved in 95.5% of the patients. Conclusion: Preoperative CRT with S-1 plus oxaliplatin had a high pCR rate and a favorable toxicity profile. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
-
The Indian journal of surgery 77(4) 283-289 2015年8月 査読有り
-
Annals of Surgical Oncology 22(6) 2040-2050 2015年6月1日 査読有りMethods: We conducted a propensity scoring matched case–control study of colon and rectal cancer patients aged ≥80 years using data from 41 hospitals between 2003 and 2007. A total of 1,526 colon cancer patients and 282 rectal cancer patients underwent surgery and were included in the analysis. The primary end point was 3-year overall survival (OS). Secondary end points included disease-free survival (DFS), cancer-specific survival (CSS), and postoperative complications. Results: LAP and OP were compared in 804 colon cancer patients (402 pairs) and 114 rectal cancer patients (57 pairs) after all covariates were balanced, and no significant differences were observed, except for tumor size in colon cancer. OS, DFS, and CSS did not differ between the groups for either colon cancer (P = 0.916, 0.968, and 0.799, respectively) or rectal cancer (P = 0.765, 0.519, and 0.950, respectively). In colon cancer cases, LAP was associated with fewer morbidities than was OP (24.9 vs. 36.3 %, P < 0.001) no such difference was observed for rectal cancer patients (47.4 vs. 40.4 %, P = 0.450). Conclusions: LAP is an acceptable alternative to OP in elderly patients with colorectal cancer. Background: The safety of laparoscopic surgery (LAP) in elderly patients with colorectal cancer has not been demonstrated. The aim of this study was to compare the outcomes of LAP and open surgery (OP) and estimate the feasibility of LAP in colorectal cancer patients aged ≥80 years.
MISC
321共同研究・競争的資金等の研究課題
9-
日本学術振興会 科学研究費助成事業 2022年4月 - 2025年3月
-
日本学術振興会 科学研究費助成事業 2022年4月 - 2025年3月
-
日本学術振興会 科学研究費助成事業 2021年4月 - 2024年3月
-
日本学術振興会 科学研究費助成事業 2019年4月 - 2022年3月
-
日本学術振興会 科学研究費助成事業 2017年4月 - 2020年3月