基本情報
- 所属
- 自治医科大学 医学部生理学講座 生物物理学部門 講師
- 学位
- 理学博士(東京工業大学)
- J-GLOBAL ID
- 201501016752737126
- researchmap会員ID
- B000247210
- 外部リンク
研究分野
1経歴
6-
2018年1月 - 現在
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2015年4月 - 2017年12月
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2014年4月 - 2015年3月
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2011年4月 - 2014年3月
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2009年10月 - 2011年3月
学歴
1-
- 2009年3月
受賞
3-
2015年9月
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2014年11月
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2009年9月
論文
77-
Science Advances 10(24) 2024年6月14日 査読有りCertain cyanobacteria alter their photosynthetic light absorption between green and red, a phenomenon called complementary chromatic acclimation. The acclimation is regulated by a cyanobacteriochrome-class photosensor that reversibly photoconverts between green-absorbing (Pg) and red-absorbing (Pr) states. Here, we elucidated the structural basis of the green/red photocycle. In the Pg state, the bilin chromophore adopted the extended C15- Z , anti structure within a hydrophobic pocket. Upon photoconversion to the Pr state, the bilin is isomerized to the cyclic C15- E , syn structure, forming a water channel in the pocket. The solvation/desolvation of the bilin causes changes in the protonation state and the stability of π-conjugation at the B ring, leading to a large absorption shift. These results advance our understanding of the enormous spectral diversity of the phytochrome superfamily.
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Journal of the American Chemical Society 145(50) 27512-27520 2023年12月7日 査読有り
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Angewandte Chemie (International ed. in English) e202309694 2023年8月31日 査読有りMolecular motion in the solid state is typically precluded by the highly dense environment, and only molecules with a limited range of sizes show such dynamics. Here, we demonstrate the solid-state rotational motion of two giant molecules, i.e., triptycene and pentiptycene, by encapsulating a bulky N-heterocyclic carbene (NHC) Au(I) complex in the crystalline media. To date, triptycene is the largest molecule (surface area: 245 Å2 ; volume: 219 Å3 ) for which rotation has been reported in the solid state, with the largest rotational diameter among reported solid-state molecular rotors (9.5 Å). However, the pentiptycene rotator that is the subject of this study (surface area: 392 Å2 ; volume: 361 Å3 ; rotational diameter: 13.0 Å) surpasses this record. Single-crystal X-ray diffraction analyses of both the developed rotors revealed that these possess sufficient free volume around the rotator. The molecular motion in the solid state was confirmed using variable-temperature solid-state 2 H spin-echo NMR studies. The triptycene rotor exhibited three-fold rotation, while temperature-dependent changes of the rotational angle were observed for the pentiptycene rotor.
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Chemistry – A European Journal 2023年8月15日 査読有りControlled self‐assembly of Pt(II) complexes is key to the development of optical and stimuli‐responsive materials, but designing and precisely controlling them is still difficult owing to weak intermolecular interactions. Herein, we report the successful water‐vapor‐induced assembly of an anionic Pt(II) complex [Pt(CN)2(ppy)]– (Hppy = 2‐phenylpyridine) electrostatically loaded on cationically charged layered double hydroxide (LDH) nanoparticles consisting of Mg2+ and Al3+ ions. When the Pt(II) complexes were densely loaded onto the LDH nanoparticles, the assembly was maintained, even in dilute aqueous media. In the case of sparse loading, the Pt(II) complexes were loaded discretely in the dry state; however, when water vapor was adsorbed, the increased mobility of the Pt(II) complexes led to their assembly on the LDH nanoparticles. This resulted in a drastic change in luminescence from green to orange owing to the presence of water vapor.
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Journal of synchrotron radiation 30(Pt 2) 368-378 2023年3月1日 査読有りX-ray fluorescence holography (XFH) is a powerful atomic resolution technique capable of directly imaging the local atomic structure around atoms of a target element within a material. Although it is theoretically possible to use XFH to study the local structures of metal clusters in large protein crystals, the experiment has proven difficult to perform, especially on radiation-sensitive proteins. Here, the development of serial X-ray fluorescence holography to allow the direct recording of hologram patterns before the onset of radiation damage is reported. By combining a 2D hybrid detector and the serial data collection used in serial protein crystallography, the X-ray fluorescence hologram can be directly recorded in a fraction of the measurement time needed for conventional XFH measurements. This approach was demonstrated by obtaining the Mn Kα hologram pattern from the protein crystal Photosystem II without any X-ray-induced reduction of the Mn clusters. Furthermore, a method to interpret the fluorescence patterns as real-space projections of the atoms surrounding the Mn emitters has been developed, where the surrounding atoms produce large dark dips along the emitter-scatterer bond directions. This new technique paves the way for future experiments on protein crystals that aim to clarify the local atomic structures of their functional metal clusters, and for other related XFH experiments such as valence-selective XFH or time-resolved XFH.
MISC
29-
ECS Meeting Abstracts 2021年5月30日
講演・口頭発表等
72担当経験のある科目(授業)
7-
生命科学(物理分野) (自治医科大学)
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生命科学(実習) (自治医科大学)
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生命科学(演習) (自治医科大学)
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光科学の医学・生命科学への応用 (自治医科大学)
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生物物理学入門 (自治医科大学)
所属学協会
4共同研究・競争的資金等の研究課題
3-
文部科学省 新学術領域研究(研究領域提案型) 2017年 - 2022年
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文部科学省 科学研究費補助金(若手研究(B)) 2014年 - 2016年
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自治医科大学 医学部研究奨励金 2016年