Safety of intracranial AAV vector injection in cynomolgus monkeys

Hiroaki Mizukami, Shin-Ichi Muramatsu, Fumiko Ono, Jun Mimuro, Yoichi Sakata, Masashi Urabe, Akihiro Kume, Keiji Terao, Imaharu Nakano, Keiya Ozawa

JOURNAL OF GENE MEDICINE 10(4) 454-454 2008年4月査読有り
Prevalence of neutralizing antibody against AAV serotypes 1, 8 and 9 in cynomolgus monkey colonies

Hiroaki Mizukami, Akira Ishiwata, Fumiko Ono, Jun-Ichiro Takano, Koji Fujimoto, Jun Mimuro, Masashi Urabe, Akihiro Kume, Keiji Terao, Yoichi Sakata, Keiya Ozawa

JOURNAL OF GENE MEDICINE 10(4) 453-453 2008年4月査読有り
Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea

Yuhe Liu, Takashi Okada, Kuniko Shimazaki, Kianoush Sheykholeslami, Tatsuya Nomoto, Shin-Ichi Muramatsu, Hiroaki Mizukami, Akihiro Kume, Shuifang Xiao, Keiichi Ichimura, Keiya Ozawa

MOLECULAR THERAPY 16(3) 474-480 2008年3月
Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice

Yuji Takei, Yasushi Saga, Hiroaki Mizukami, Takeshi Takayama, Michitaka Ohwada, Keiya Ozawa, Mitsuaki Suzuki

MOLECULAR CANCER THERAPEUTICS 7(3) 704-711 2008年3月
Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea

Yuhe Liu, Takashi Okada, Kuniko Shimazaki, Kianoush Sheykholeslami, Tatsuya Nomoto, Shin-Ichi Muramatsu, Hiroaki Mizukami, Akihiro Kume, Shuifang Xiao, Keiichi Ichimura, Keiya Ozawa

MOLECULAR THERAPY 16(3) 474-480 2008年3月査読有り
Adeno-associated virus vector-mediated production of hepatocyte growth factor attenuates liver fibrosis in mice

Kazuhiro Suzumura, Tadamichi Hirano, Gakuhei Son, Yuji Iimuro, Hiroaki Mizukami, Keiya Ozawa, Jiro Fujimoto

HEPATOLOGY INTERNATIONAL 2(1) 80-88 2008年3月査読有り
Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice

Yuji Takei, Yasushi Saga, Hiroaki Mizukami, Takeshi Takayama, Michitaka Ohwada, Keiya Ozawa, Mitsuaki Suzuki

MOLECULAR CANCER THERAPEUTICS 7(3) 704-711 2008年3月査読有り
Low seropositivity against AAV serotypes 1, 8, and 9 in specific pathogen-free cynomolgus monkey colony

Hiroaki Mizukami, Akira Ishiwata, Fumiko Ono, Junichiro Takano, Koji Fujimoto, Jun Mimuro, Masashi Urabe, Akihiro Kume, Keiji Terao, Yoichi Sakata, Keiya Ozawa

HUMAN GENE THERAPY 18(10) 1044-1044 2007年10月査読有り
Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats

Takayuki Ito, Takashi Okada, Hiroshi Miyashita, Tatsuya Nomoto, Mutsuko Nonaka-Sarukawa, Ryosuke Uchibori, Yoshikazu Maeda, Masashi Urabe, Hiroaki Mizukami, Akihiro Kume, Masafumi Takahashi, Uichi Ikeda, Kazuyuki Shimada, Keiya Ozawa

CIRCULATION RESEARCH 101(7) 734-741 2007年9月
Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats

Takayuki Ito, Takashi Okada, Jun Mimuro, Hiroshi Miyashita, Ryosuke Uchibori, Masashi Urabe, Hiroaki Mizukami, Akihiro Kume, Masafumi Takahashi, Uichi Ikeda, Yoichi Sakata, Kazuyuki Shimada, Keiya Ozawa

HYPERTENSION 50(3) 531-536 2007年9月
Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats

Takayuki Ito, Takashi Okada, Hiroshi Miyashita, Tatsuya Nomoto, Mutsuko Nonaka-Sarukawa, Ryosuke Uchibori, Yoshikazu Maeda, Masashi Urabe, Hiroaki Mizukami, Akihiro Kume, Masafumi Takahashi, Uichi Ikeda, Kazuyuki Shimada, Keiya Ozawa

CIRCULATION RESEARCH 101(7) 734-741 2007年9月査読有り
ベクター産生型間葉系幹細胞の癌自殺遺伝療法への応用(Retroviral vector-producing mesenchymal stem cells for reinforcement of systemic suicide cancer gene therapy)

内堀亮介, 岡田尚巳, 伊藤孝幸, 卜部匡司, 水上浩明, 久米晃啓, 小澤敬也

日本癌学会総会記事 66回 197-197 2007年8月
Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector

Yuji Takei, Hiroaki Mizukami, Yasushi Saga, Ichiro Yoshimura, Yoko Hasumi, Takeshi Takayama, Takahiro Kohno, Takashi Matsushita, Takashi Okada, Akihiro Kume, Mitsuaki Suzuki, Keiya Ozawa

INTERNATIONAL JOURNAL OF CANCER 120(2) 278-284 2007年1月
Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model

Junichi Ideno, Hiroaki Mizukami, Akihiro Kakehashi, Yuka Saito, Takashi Okada, Masashi Urabe, Akihiro Kume, Masatoshi Kuroki, Masanobu Kawakami, Shun Ishibashi, Keiya Ozawa

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 19(1) 75-79 2007年1月
Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector

Yuji Takei, Hiroaki Mizukami, Yasushi Saga, Ichiro Yoshimura, Yoko Hasumi, Takeshi Takayama, Takahiro Kohno, Takashi Matsushita, Takashi Okada, Akihiro Kume, Mitsuaki Suzuki, Keiya Ozawa

INTERNATIONAL JOURNAL OF CANCER 120(2) 278-284 2007年1月査読有り
Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model

Junichi Ideno, Hiroaki Mizukami, Akihiro Kakehashi, Yuka Saito, Takashi Okada, Masashi Urabe, Akihiro Kume, Masatoshi Kuroki, Masanobu Kawakami, Shun Ishibashi, Keiya Ozawa

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 19(1) 75-79 2007年1月査読有り
Tendon healing in vitro: Adeno-associated virus-2 effectively transduces intrasynovial tenocytes with persistent expression of the transgene, but other serotypes do not

Xiao Tian Wang, Paul Y. Liu, Jin Bo Tang, Hiroaki Mizukami, Ke-Qin Xin, Keiya Ozawa, Hiroshi Ushijima

PLASTIC AND RECONSTRUCTIVE SURGERY 119(1) 227-234 2007年1月査読有り
Targeted insertion of transgene into a specific site on chromosome 19 by using adeno-associated virus integration machinery

Masashi Urabe, Yoko Obara, Takayuki Ito, Hiroaki Mizukami, Akihiro Kume, Keiya Ozawa

Autologous And Cancer Stem Cell Gene Therapy 19-46 2007年1月1日
Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells

Ke-Qin Xin, Hiroaki Mizukami, Masashi Urabe, Yoshihiko Toda, Kaori Shinoda, Atsushi Yoshida, Kenji Oomura, Yoshitsugu Kojima, Motohide Ichino, Dennis Klinman, Keiya Ozawa, Kenji Okuda

JOURNAL OF VIROLOGY 80(24) 11899-11910 2006年12月
Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells

Ke-Qin Xin, Hiroaki Mizukami, Masashi Urabe, Yoshihiko Toda, Kaori Shinoda, Atsushi Yoshida, Kenji Oomura, Yoshitsugu Kojima, Motohide Ichino, Dennis Klinman, Keiya Ozawa, Kenji Okuda

JOURNAL OF VIROLOGY 80(24) 11899-11910 2006年12月査読有り
Utility of AAV serotype-based vectors in mice and non-human primates

Hiroaki Mizukami, Jun Mimuro, Akira Ishiwata, Fumiko Ono, Takashi Matsushita, Takashi Okada, Masashi Urabe, Akihiro Kume, Keiji Terao, Yoichi Sakata, Keiya Ozawa

JOURNAL OF GENE MEDICINE 8(12) 1460-1460 2006年12月査読有り
Adipose tissue as a novel target for in vivo gene transfer by adeno-associated viral vectors

Hiroaki Mizukami, Jun Mimuro, Tsuyoshi Ogura, Takashi Okada, Masashi Urabe, Akihiro Kume, Yoichi Sakata, Keiya Ozawa

HUMAN GENE THERAPY 17(9) 921-928 2006年9月査読有り
ベクター産生型腫瘍標的細胞を用いた治療遺伝子増幅と病巣イメージング

内堀亮介, 岡田尚巳, 卜部匡司, 水上浩明, 久米晃啓, 小澤敬也

日本癌学会総会記事 65回 503-503 2006年9月
Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer

Tsuyoshi Ogura, Hiroaki Mizukami, Jun Mimuro, Seiji Madoiwa, Takashi Okada, Takashi Matsushita, Masashi Urabe, Akihiro Kume, Hirorni Hamada, Hiroyuki Yoshikawa, Yoichi Sakata, Keiya Ozawa

JOURNAL OF GENE MEDICINE 8(8) 990-997 2006年8月査読有り
AAV8-Mediated Transgene Expression in Mice and Non-Human Primates

Hiroaki Mizukami, Jun Mimuro, Akira Ishiwata, Fumiko Ono, Takashi Matsushita, Takashi Okada, Masashi Urabe, Akihiro Kume, Keiji Terao, Yoichi Sakata, Keiya Ozawa

MOLECULAR THERAPY 13 S3-S3 2006年5月査読有り
A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells

T Okada, R Uchibori, M Iwata-Okada, M Takahashi, T Nomoto, M Nonaka-Sarukawa, T Ito, Y Liu, H Mizukami, A Kume, E Kobayashi, K Ozawa

MOLECULAR THERAPY 13(4) 738-746 2006年4月査読有り
Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression

M Urabe, KQ Xin, Y Obara, T Nakakura, H Mizukami, A Kume, K Okuda, K Ozawa

MOLECULAR THERAPY 13(4) 823-828 2006年4月査読有り
Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells

M Urabe, T Nakakura, KQ Xin, Y Obara, H Mizukami, A Kume, RM Kotin, K Ozawa

JOURNAL OF VIROLOGY 80(4) 1874-1885 2006年2月査読有り
Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer.

Ogura, T, Mizukami, H, Mimuro, J, Madoiwa, S, Okada, T, Matsushita, T, Urabe, M, Kume, A, Hamada, H, Yoshikawa, H, Sakata, Y, Ozawa, K

J Gene Med 8 990-7 2006年
Adipose tissue as a novel target for in vivo gene transfer by using adeno-associated virus vectors.

Mizukami, H, Mimuro, J, Ogura, T, Okada, T, Urabe, M, Kume, A, Sakata, Y, Ozawa, K

Hum Gene Ther 17 921-8 2006年
Phenotype correction of hemophilia A mice with adeno-associated virus vectors carrying the B domain-deleted canine factor VIII gene

Akira Ishiwata, Jun Mimuro, Yuji Kashiwakura, Masanori Niimura, Katsuhiro Takano, Tsukasa Ohmori, Seiji Madoiwa, Hiroaki Mizukami, Takashi Okada, Hiroyuki Naka, Akira Yoshioka, Keiya Ozawa, Yoichi Sakata

THROMBOSIS RESEARCH 118(5) 627-635 2006年査読有り
Repair of articular cartilage defect by Intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector

A Hiraide, N Yokoo, KQ Xin, K Okuda, H Mizukami, K Ozawa, T Saito

HUMAN GENE THERAPY 16(12) 1413-1421 2005年12月査読有り
Specific and efficient transduction of cochlear inner hair cells with recombinant adeno-associated virus type 3 vector

YH Liu, T Okada, K Sheykholeslami, K Shimazaki, T Nomoto, SI Muramatsu, T Kanazawa, K Takeuchi, R Ajalli, H Mizukami, A Kume, K Ichimura, K Ozawa

MOLECULAR THERAPY 12(4) 725-733 2005年10月査読有り
Large-scale production of recombinant viruses by use of a large culture vessel with active gassing

T Okada, T Nomoto, T Yoshioka, M Nonaka-Sarukawa, T Ito, T Ogura, M Iwata-Okada, R Uchibori, K Shimazaki, H Mizukami, A Kume, K Ozawa

HUMAN GENE THERAPY 16(10) 1212-1218 2005年10月査読有り
Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease

M Maruyama, M Higuchi, Y Takaki, Y Matsuba, H Tanji, M Nemoto, N Tomita, T Matsui, N Iwata, H Mizukami, SI Muramatsu, K Ozawa, TC Saido, H Arai, H Sasaki

ANNALS OF NEUROLOGY 57(6) 832-842 2005年6月査読有り
Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro

Y Takei, H Mizukami, Y Saga, H Kobayashi, M Suzuki, T Matsushita, K Ozawa, M Suzuki

INTERNATIONAL JOURNAL OF CANCER 113(1) 54-58 2005年1月
Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro

Y Takei, H Mizukami, Y Saga, H Kobayashi, M Suzuki, T Matsushita, K Ozawa, M Suzuki

INTERNATIONAL JOURNAL OF CANCER 113(1) 54-58 2005年1月査読有り
Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector

N Yokoo, T Saito, M Uesugi, N Kobayashi, KQ Xin, K Okuda, H Mizukami, K Ozawa, T Koshino

ARTHRITIS AND RHEUMATISM 52(1) 164-170 2005年1月査読有り
Sustained transgene expression by human cord blood derived CD34+ cells transduced with simian immunodeficiency virus agmTYO(1)-based vectors carrying the human coagulation factor VIII gene in NOD/SCID mice

J Kikuchi, J Mimuro, K Ogata, T Tabata, Y Ueda, A Ishiwata, K Kimura, K Takano, S Madoiwa, H Mizukami, Y Hanazono, A Kume, M Hasegawa, K Ozawa, Y Sakata

JOURNAL OF GENE MEDICINE 6(10) 1049-1060 2004年10月査読有り
Topoisomerase inhibitors enhance the cytocidal effect of AAV-HSVtk/ganciclovir on head and neck cancer cells

T Kanazawa, H Mizukami, H Nishino, T Okada, Y Hanazono, A Kume, K Kitamura, K Ichimura, K Ozawa

INTERNATIONAL JOURNAL OF ONCOLOGY 25(3) 729-735 2004年9月査読有り
Expansion of genetically corrected neutrophils in chronic granulomatous disease mice by cotransferring a therapeutic gene and a selective amplifier gene

T Hara, A Kume, Y Hanazono, H Mizukami, T Okada, H Tsurumi, H Moriwaki, Y Ueda, M Hasegawa, K Ozawa

GENE THERAPY 11(18) 1370-1377 2004年9月査読有り
The adenovirus E1A and E1B19K genes provide a helper function for transfection-based adeno-associated virus vector production

T Matsushita, T Okada, T Inaba, H Mizukami, K Ozawa, P Cojosi

JOURNAL OF GENERAL VIROLOGY 85 2209-2214 2004年8月査読有り
Long-term correction of hyperphenylalaninemia by AAV-mediated gene transfer leads to behavioral recovery in phenylketonuria mice

S Mochizuki, H Mizukami, T Ogura, S Kure, A Ichinohe, K Kojima, Y Matsubara, E Kobayahi, T Okada, A Hoshika, K Ozawa, A Kume

GENE THERAPY 11(13) 1081-1086 2004年7月
Is fenestration a safe treatment for adult polycystic liver disease? A report of refractory complications

K Ishibashi, T Midorikawa, H Kikuchi, Y Fujiwara, H Izuno, T Hatakeyama, M Saito, K Miyakawa, H Mizukami, K Maezawa, H Nemoto, Y Sanada

HEPATO-GASTROENTEROLOGY 51(58) 1165-1167 2004年7月査読有り
Separate control of Rep and Cap expression using mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production

H Mizukami, T Okada, Y Ogasawara, T Matsushita, M Urabe, A Kume, K Ozawa

MOLECULAR BIOTECHNOLOGY 27(1) 7-14 2004年5月
Separate control of Rep and Cap expression using mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production

H Mizukami, T Okada, Y Ogasawara, T Matsushita, M Urabe, A Kume, K Ozawa

MOLECULAR BIOTECHNOLOGY 27(1) 7-14 2004年5月査読有り
Specific detection of human coagulation factor IX in cynomolgus macaques

J Mimuro, H Mizukami, F Ono, S Madoiwa, K Terao, A Yoshioka, K Ozawa, Y Sakata

JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2(2) 275-280 2004年2月査読有り
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain

N Iwata, H Mizukami, K Shirotani, Y Takaki, S Muramatsu, B Lu, NP Gerard, C Gerard, K Ozawa, TC Saido

JOURNAL OF NEUROSCIENCE 24(4) 991-998 2004年1月査読有り
Successful gene transfer using adeno-associated virus vectors into the kidney: comparison among adeno-associated virus serotype 1-5 vectors in vitro and in vivo.

Takeda S, Takahashi M, Mizukami H, Kobayashi E, Takeuchi K, Hakamata Y, Kaneko T, Yamamoto H, Ito C, Ozawa K, Ishibashi K, Matsuzaki T, Takata K, Asano Y, Kusano E

Nephron. Experimental nephrology 96 e119-26 2004年査読有り
Successful gene transfer using adeno-associated virus vectors into the kidney: Comparison among adeno-associated virus serotype 1-5 vectors in vitro and in vivo

Shin-Ichi Takeda, Masafumi Takahashi, Hiroaki Mizukami, Eiji Kobayashi, Koichi Takeuchi, Yoji Hakamata, Takashi Kaneko, Hisashi Yamamoto, Chiharu Ito, Keiya Ozawa, Kenichi Ishibashi, Toshiyuki Matsuzaki, Kuniaki Takata, Yasushi Asano, Eiji Kusano

Nephron - Experimental Nephrology 96(4) e119-e126 2004年査読有り

MISC

196

複数ライフステージをワクチンターゲットにした熱帯熱マラリアワクチンの開発

水野哲志, Andrew Blagborough, 新倉保, 伊從光洋, 水上浩明, 志田壽利, 吉田栄人

臨床とウイルス 51(3) 126-126 2023年9月
マーモセット前頭前野からの皮質間および,皮質線条体投射が示す2つの対照的な特徴について

渡我部昭哉, SKIBBE Henrik, 中江健, 阿部央, 一戸紀孝, WANG Jian, 高司雅史, 水上浩明, WOODWARD Alexander, GONG Rui, 畑純一, 岡野栄之, 石井信

日本神経化学会大会抄録集(Web) 65th 2022年
自閉症モデルマーモセットの背内側前頭前皮質におけるシナプスのターンオーバーとシナプス間相互作用の解析

野口潤, 渡邉惠, 磯田李紗, 中垣慶子, 境和久, 菅野江里子, 冨田浩史, 渡我部昭哉, 山森哲雄, 水上浩明, 一戸紀孝

日本神経化学会大会抄録集(Web) 65th 2022年
Temporal profile of transient corticomotoneuronal direct connection in the rodent.

Ohno, T, Fukuda, S, Murabe, N, Mizukami, H, Ozawa, K, Hayashi, T, Sakurai, M

Society for Neuroscience 2019年10月
Transient synapse formation and regression of direct cortico-motoneuronal synapses during development in rodents.

Fukuda, S, Ohno, T, Murabe, N, Niido, M, Mizukami, H, Ozawa, K, Hayashi, T, Sakurai, M

The 42st Annual Meeting of the Japan Neuroscience Society 2019年7月

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『糖尿病学ー基礎と臨床』

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日本学術振興会科学研究費助成事業 2025年4月 - 2028年3月

吉田栄人, 水上浩明, 日紫喜隆行, 山本祐太朗, 渡士幸一, 小川良平, 綿野亮太, 倉石貴透
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日本学術振興会科学研究費助成事業 2023年4月 - 2026年3月

北山丈二, 山口博紀, 大澤英之, 齋藤心, 宮戸秀世, 金丸理人, 寺谷工, 水上浩明, 綿野亮太
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感染防御・伝播阻止両機能を発揮する三日熱マラリアワクチン開発研究

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