研究者業績

仲宗根 秀樹

Hideki Nakasone

基本情報

所属
自治医科大学 分子病態治療研究センター 領域融合治療研究部 / さいたま医療センター血液科 教授

J-GLOBAL ID
201501000612691971
researchmap会員ID
B000247677

論文

 260
  • Hideki Nakasone, Michiko Kida, Seiko Iki, Kensuke Usuki
    Leukemia research 32(4) 659-64 2008年4月  査読有り
  • Yuki Asano-Mori, Yoshinobu Kanda, Kumi Oshima, Shinichi Kako, Akihito Shinohara, Hideki Nakasone, Hiroyuki Sato, Takuro Watanabe, Noriko Hosoya, Koji Izutsu, Takashi Asai, Akira Hangaishi, Toru Motokura, Shigeru Chiba, Mineo Kurokawa
    International journal of hematology 87(3) 310-8 2008年4月  査読有り
  • Kumi Oshima, Yoshinobu Kanda, Hideki Nakasone, Shunya Arai, Nahoko Nishimoto, Hiroyuki Sato, Takuro Watanabe, Noriko Hosoya, Koji Izutsu, Takashi Asai, Akira Hangaishi, Toru Motokura, Shigeru Chiba, Mineo Kurokawa
    American journal of hematology 83(3) 226-32 2008年3月  査読有り
  • Yuki Asano-Mori, Yoshinobu Kanda, Kumi Oshima, Shinichi Kako, Akihito Shinohara, Hideki Nakasone, Makoto Kaneko, Hiroyuki Sato, Takuro Watanabe, Noriko Hosoya, Koji Izutsu, Takashi Asai, Akira Hangaishi, Toru Motokura, Shigeru Chiba, Mineo Kurokawa
    The Journal of antimicrobial chemotherapy 61(2) 411-6 2008年2月  査読有り
  • Kensuke Usuki, Hideki Nakasone, Kazuki Taoka, Michiko Kida, Seiko Iki, Akio Urabe
    [Rinsho ketsueki] The Japanese journal of clinical hematology 48(8) 618-23 2007年8月  査読有り
    Twenty-three patients with acute myelogenous leukemia (AML) have received autologous hematopoietic stem cell transplantation (autoHSCT) in our institute from 1997 to 2005. Among them, 3 patients relapsed, and the other 4 patients (17%) showed cytogenetic abnormalities after the autoHSCT. In these 4 patients with AML1/MTG8 or CBFbeta/MYH11 AML, RT-PCR findings using bone marrow cells were all negative when a cytogenetic abnormality was detected. Myelodysplasia was not detected in the bone marrow and no abnormal findings were seen in the peripheral blood. Cytogenetic abnormalities were detected 12-48 months after AutoHSCT, which disappeared in three patients and decreased in the remaining one patient with a median follow up time of 51 months (30-72 months) after their detection. We present our finding together with a review of the literature on post-autoHSCT cytogenetic abnormalities not related to relapse or secondary leukemia/myelodysplastic syndrome.
  • Usukine K, Shinhori H, Idetsuki T, Taoka K, Nakasone H, Kida M, Iki S, Urabe M, Oseto K, Igarashi A
    [Rinsho ketsueki] The Japanese journal of clinical hematology 48(5) 351-352 2007年5月  査読有り
  • Akihide Yoshimi, Kazuki Taoka, Hideki Nakasone, Kimiko Iijima, Michiko Kida, Seiko Iki, Akio Urabe, Kensuke Usuki
    [Rinsho ketsueki] The Japanese journal of clinical hematology 47(12) 1533-8 2006年12月  査読有り
    Superior sagittal sinus thrombosis (SSST) has been reported to be caused by coagulopathy following oral contraceptive therapy, DIC, infection around the sinus, compression from a tumor, infiltration of tumor, and an inherited deficiency of proteins C and S, but SSST associated with hematological malignancies and L-asparaginase (L-Asp) therapy is rare. We report a case of an adult patient with acute lymphoblastic leukemia (ALL) who developed SSST during the remission induction therapy. A 25-year-old man was admitted with left facial nerve palsy and, following bone marrow aspiration and lumbar puncture, he was diagnosed as having T-ALL with CNS involvement. He received a 1-AdVP regimen as remission induction therapy and intrathecal administration of methotrexate and cytarabine. On day 29, he had a generalized convulsion and SSST was demonstrated by imaging tests. Lymphoid malignancy (ALL in particular), the use of L-Asp, CNS involvement, and intrathecal chemotherapy might be risk factors for the occurrence SSST. When a patient with those factors develops any neurological symptoms, we should pay attention to the occurrence of SSST, as well as stroke or CNS involvement, though SSST is rare.
  • N Takeda, T Takahashi, Y Seko, K Maemura, H Nakasone, K Sakamoto, Y Hirata, R Nagai
    INTERNAL MEDICINE 44(3) 256-260 2005年3月  査読有り
  • 仲宗根 秀樹, 武田 憲文, 坂本 啓, 高橋 利之, 新藤 隆行, 松本 晃裕, 世古 義規, 大野 実, 平田 恭信, 永井 良三
    日本内科学会関東地方会 506回 26-26 2003年2月  査読有り
  • Sunagawa T, Nakasone H, Kochi A, Sakugawa H, Kinjo F, Saito A, Morioka T, Arakaki Y, Ito E
    琉球医学会誌 = Ryukyu Medical Journal 17(1) 57-60 1997年  査読有り
    An autopsy case of T-cell lymphoma complicated with hemophagocytic syndrome (HPS) is reported. A 60-year-old woman presenting with fever and jaundice was transferred to our hospital. On admission, she showed bicytopenia, severe liver dysfunction and coagulopathy. She subsequently developed pancytopenia. At first, she was suspected of having aplastic anemia. Methylpredonisolone pulse therapy was therefore initiated, and the leukopenia improved. But she later developed leukopenia again, and died of septic shock. At autopsy, proliferation of histiocytes with hemophagocytosis was observed in the reticuloendothelial system. Moreover, T-cell lymphoma was observed. Hence diagnosis of T-cell lymphoma with HPS was made pathologically.

MISC

 93

共同研究・競争的資金等の研究課題

 5