医学部 解剖学講座 法医学部門

鈴木 秀人

スズキ ヒデト  (Hideto Suzuki)

基本情報

所属
自治医科大学 医学部 解剖学講座法医学部門 教授
学位
医学博士

研究者番号
00508749
J-GLOBAL ID
202301000496834370
researchmap会員ID
R000047053

論文

 42
  • Hideto Suzuki, Hisanori Muramatsu, Kino Hayashi
    Legal Medicine 62 102222 2023年2月  査読有り筆頭著者責任著者
  • Shuntaro Ando, Hideto Suzuki, Takehisa Matsukawa, Satoshi Usami, Hisanori Muramatsu, Tatsushige Fukunaga, Kazuhito Yokoyama, Yuji Okazaki, Atsushi Nishida
    Translational Psychiatry 12(1) 466-466 2022年11月7日  査読有り
    Abstract Ecological studies have suggested the protective effect of micro-dose lithium in drinking water against suicide, however, the association between body lithium level and suicide is unknown. We aimed to compare body lithium levels between suicide and non-suicide fatalities. This cross-sectional study included 12 suicides and 16 non-suicides who were examined or dissected at the Tokyo Medical Examiner’s Office from March 2018 to June 2021. The aqueous humor lithium concentration was measured twice using inductively coupled plasma mass spectrometry. Analysis of covariance (ANCOVA) was used to compare the lithium concentration between suicides and non-suicides. Mixed-effects model was conducted to account for all lithium concentration data. The aqueous humor lithium concentration did not change after death (t(7) = −0.70, $$\bar v = - 0.02$$, SE = 0.03, 95% CI = [−0.09, 0.05], P = 0.51, Cohen’s d = 0.01). The aqueous humor lithium concentration was lower in suicides (mean 0.50 μg/L (variance s2 0.04)) than in non-suicides (mean 0.92 μg/L (s2 0.07)) (t(26) = 4.47, $$\bar v = 0.42$$, SE = 0.09, 95% CI = [0.22 to 0.61], P < 0.001, Cohen’s d = 1.71). The ANCOVA showed that death by suicide was significantly associated with lower lithium concentration (F(1, 24) = 8.57, P = 0.007), and the effect size was large (ηp2 = 0.26). The random intercept model showed a significant effect of suicide on aqueous humor lithium concentration (b = −0.261, SE = 0.102, 95% CI = [−0.471 to −0.051], t(24) = −2.568, P = 0.017). The results of this study demonstrate that even micro-dose lithium is associated with suicide death. Clinical studies are warranted to examine the effects of micro-dose lithium on suicide prevention.
  • Hideto Suzuki, Ayako Ro, Aya Takada, Kazuyuki Saito, Kino Hayashi
    Legal Medicine 59 102134 2022年11月  査読有り筆頭著者責任著者
  • Hideto Suzuki, Tatsushige Fukunaga
    Legal Medicine 47 101774 2020年11月  査読有り筆頭著者責任著者

MISC

 10

担当経験のある科目(授業)

 2

共同研究・競争的資金等の研究課題

 2

社会貢献活動

 1