研究者業績

長嶋 孝夫

ナガシマ タカオ  (Takao Nagashima)

基本情報

所属
自治医科大学 医学部 総合医学第1講座 教授

J-GLOBAL ID
201401017706226832
researchmap会員ID
B000237688

経歴

 1

論文

 46
  • Jun Nakamura, Takao Nagashima, Katsuya Nagatani, Taku Yoshio, Masahiro Iwamoto, Seiji Minota
    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 19(5) 470-475 2016年5月  査読有り
    Objective: To examine the incidence of hepatitis B virus (HBV) reactivation in patients with rheumatoid arthritis (RA) receiving biological disease-modifying antirheumatic drugs (DMARDs). Methods: We retrospectively reviewed RA patients treated with biological DMARDs at our institution from July 2010 to December 2012. Patients with antibodies for hepatitis B core antigen and/or hepatitis B surface antigen were regarded as having prior HBV infection. Clinical data on these patients, including HBV-DNA levels, were retrieved from the medical records. Results: During the study period, 251 patients were administered various biological DMARDs. Six patients with a history of HBV vaccination and one patient with positive HBV surface antigen were excluded from the study. Fifty-seven of the remaining 244 patients (23.4%) had prior HBV infection. These patients were followed for a median of 18 months (range: 2-27 months) and HBV-DNA was examined a median of seven times (range: 227). HBV-DNA was detected in three patients (5.3%), comprising two receiving tocilizumab and one receiving etanercept. However, HBV-DNA levels were below the quantitation limit (<2.1 log copies mL(-1)) in all three patients. HBV-DNA became negative again within several months in all three patients, while biological DMARDs were continued and liver function tests remained normal throughout. Conclusion: HBV-DNA reactivation occurred in 5.3% of RA patients with prior HBV infection during treatment with biological DMARDs, but there were no associated clinical manifestations. Accordingly, it seems that biological DMARDs can be used safely in patients with RA.
  • Takao Nagashima, Seiji Minota
    RHEUMATOLOGY INTERNATIONAL 34(7) 1025-1026 2014年7月  査読有り
  • Takamasa Murosaki, Takao Nagashima, Kyoko Honne, Yoko Aoki, Seiji Minota
    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 17(4) 476-478 2014年5月  査読有り
  • Takao Nagashima, Kazuko Matsumoto, Takamasa Murosaki, Mari Okada, Masahiro Iwamoto, Shinji Makino, Seiji Minota
    Rheumatology International 33(7) 1915-1916 2013年7月  査読有り
  • Kyoko Honne, Takao Nagashima, Sachiko Onishi, Katsuya Nagatani, Masahiro Iwamoto, Seiji Minota
    Journal of Clinical Rheumatology 19(2) 104-105 2013年3月  査読有り

MISC

 20