基本情報
- 所属
- 自治医科大学 医学部 総合医学第２講座 主任教授
- 学位
- 博士（歯学）(東京医科歯科大学)
- J-GLOBAL ID
- 201401047987040410
- researchmap会員ID
- B000241945
- 外部リンク
研究キーワード
30経歴
1-
2009年 - 2014年
学歴
1-
1978年4月 - 1984年3月
論文
38-
JOURNAL OF CRANIOFACIAL SURGERY 25(5) E443-E445 2014年9月 査読有りWe used a piece of costal cartilage as a cartilaginous strut to correct the upturned nasal tip in patients with bilateral cleft lip. The grafted cartilage provides more definition of the tip and improves the obtuse nasolabial angle. Neither the septal cartilage nor the ear cartilage has enough strength to shape the tip. This method of correction has consistently produced favorable, long-lasting results in adults and has improved the contour of the nasal tip in younger patients.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 25(6) 1531-1538 2014年6月 査読有りRapid and efficient animal models are needed for evaluating the effectiveness of many new candidate bone regenerative materials. We developed an in vivo model screening for calvarial bone regeneration in lipopolysaccharide (LPS)-treated mice, in which materials were overlaid on the periosteum of the calvaria in a 20 min surgery and results were detectable in 1 week. Intraperitoneal LPS injection reduced spontaneous bone formation, and local application of basic fibroblast growth factor (bFGF) increased the bone-forming activities of osteoblasts. A novel synthetic collagen gel, alkali-treated collagen (AlCol) cross-linked with trisuccinimidyl citrate (TSC), acted as a reservoir for basic substances such as bFGF. The AlCol-TSC gel in conjunction with bFGF activated osteoblast activity without the delay in osteoid maturation caused by bFGF administration alone. The AlCol-TSC gel may slow the release of bFGF to improve the imbalance between osteoid formation and bone mineralization. These findings suggest that our model is suitable for screening bone regenerative materials and that the AlCOl-TSC gel functions as a candidate reservoir for the slow release of bFGF.
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BMC Research Notes 7(1) 214 2014年4月5日 査読有りBackground: Odontogenic myxoma is a benign odontogenic tumor with locally aggressive behavior, and is relatively rare in the oral cavity. There are currently no clear surgical management guidelines for odontogenic myxoma, and a variety of approaches may be used. This study evaluated the literature concerning the surgical management of odontogenic myxoma, and reports the long-term outcome of a case managed by using a more conservative surgical approach. Case presentation. We managed a 40-year-old Japanese man with odontogenic myxoma in the right mandible by enucleation and curettage, a relatively conservative approach that has proved to have been justified by a lack of recurrence over 10 years. Our strategy was compared with others reported in the literature, which was identified by a PubMed search using the term "odontogenic myxoma". Articles without full text or with missing data were excluded. The age and sex of patients, the tumor location (maxilla/mandible), treatment (conservative/radical), recurrence, and follow-up period were compared in the reported cases that we evaluated. From the initial 211 studies identified, 20 studies qualified as mandibular cases of odontogenic myxoma. Recurrence was reported in three cases that had been treated with a more conservative surgical approach. Conclusions: Enucleation and curettage has proved an effective approach in several cases in ours there has been no recurrence more than 10 years after surgery but the risk of recurrence appears to be higher. We discuss the important factors that must be considered when determining the correct management approach to odontogenic myxoma. © 2014 Kawase-Koga et al. licensee BioMed Central Ltd.
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ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 117(2) E97-E101 2014年2月 査読有りExtensive squamous cell carcinoma involving the skin of the upper lip, nasal ala, and cheek is relatively rare. Although numerous reconstruction techniques for the midface including lip, nose, and cheek have been described in the literature, reconstruction of large defects in this area continues to be challenging, as it is difficult to obtain satisfactory results with single-stage surgery. This case report concerns a 53-year-old woman with squamous cell carcinoma extending from the upper lip to the alar base and the cheek. It describes a step-by-step surgery undertaken according to defined regional aesthetic units of the face using several reconstruction methods, including a microvascular free flap, forehead flap, and conchal cartilage graft, rather than multistage reconstruction surgeries after first immediate reconstruction. Satisfactory functional and aesthetic results were achieved despite the extensive facial defects.
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BMC Research Notes 6(1) 557 2013年12月26日 査読有りBackground: Patients infected with the human immunodeficiency virus (HIV) are at risk of developing malignancies and have an increased susceptibility to infection. HIV-associated Burkitt lymphoma (BL) is relatively rare in developed countries, but remains prevalent in developing counties and is sometimes compounded by the fact that patients may be unaware that they are HIV-positive. Case presentation. A 37-year-old Japanese man was referred to our department for diagnosis and management of submandibular swelling. He was unaware that he was HIV-positive at the initial visit. Here, we describe our diagnostic approach, in which we used hematological and immunological investigations, biopsy, fluorescence-activated cell sorting and fluorescence in situ hybridization to confirm the diagnosis of HIV-associated BL. The patient has no risk factors for HIV infection, and the source of infection remains unclear. Conclusions: In this case, submandibular swelling was the first clinical sign of pathology and the patient's HIV-positive status only became evident later. It is highly likely that BL was triggered by HIV infection. © 2013 Komatsu et al. licensee BioMed Central Ltd.
MISC
54-
日本口腔外科学会雑誌 41(10) 899-901 1995年10月The hard laser is now widely used in the oral and maxillofacial region because itshemostatic ability and imploved visualization of the operative field facilitate a presice op-eration. Another important advantage of the hard laser is that some operations can be donewithout anesthesia. In this paper, six cases of epulis excised by the hard laser without anes-thesiaare presented.<BR>A CO<SUP>2</SUP> laser (one type of hard laser) was used with a continuous wave, power setting of 2 to 4 watts. All lesions could be excised completely, and no patients felt pain during laserirradiation. The operation was successful without using surgical packs, and there was nopostoperative discomfort. There has been no evidence of recurrence after operation.
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日本口腔外科学会雑誌 41(7) 662-664 1995年7月20日Streptococci are the most common species in the oral bacterial flora, which are divided into several groups according to the classification of Lancefield. A significant increase in the frequency of necrotizing inflammation and irreversible toxic shock, caused by <I>Streptococci</I> of Group A, has been recently noted. The disease appears in individuals without obvious risk factors, and often becomes serious. In contrast, inflammation caused by β-<I>Streptococci</I> of group F (<I>S. anginosus</I>), however, is usually not frequent nor serious, and has rarely been reported.<BR>We encountered a case of acute cervical cellulitis caused by odontogenic infection. A 20-year-old male was referred to our hospital with severe neck swelling and dyspnea. The lesion had extended promptly to the substernal area through the submandibular space and the cervical region, and S. anginosus and the anaerobic bacteria, <I>Peptostreptococci</I> and <I>Clostridium</I>, were detected.<BR>The lesion in this patient was managed by drainage and irrigation through incisions in the neck, and systemic antibiotic therapy was performed.<BR>In such severe infections, proper drainage and systemic antibiotic treatment are considered to be necessary.
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日本口腔科学会雜誌 44(3) 478-483 1995年7月10日The development of microvascular surgery has made possible the closures of various complicated defects resulting from surgical removal of head and neck cancers. In these days, many kinds of vascularized free flaps can be transferred from various parts of a whole body to the oral and maxillofacial defects. We experienced two cases with recurrent adenoid cystic carcinoma of the right parotid gland and the right buccal mucosa respectively. Case 1 with the lesion of parotid gland was reconstructed with latissimus dorsi-serratus anterior muscle flap with its thoracodorsal nerve.<BR>The development of microvascular surgery has made possible the closures of various complicated defects resulting from surgical removal of head and neck cancers. In these days, many kinds of vascularized free flaps can be transferred from various parts of a whole body to the oral and maxillofacial defects. We experienced two cases with recurrent adenoid cystic carcinoma of the right parotid gland and the right buccal mucosa respectively. Case 1 with the lesion of parotid gland was reconstructed with latissimus dorsi-serratus anterior muscle flap with its thoracodorsal nerve.<BR>Case 2 with the lesion of right buccal mucosa was reconstructed with free vascularized dorsalis pedis flap. Many authors have reported about application of forearm free skin flap to the reconstruction of oral cavity. However, very few reports of dorsalis pedis free skin flap in those areas had been presented. This thin flap seems to be suitable for the reconstruction of the oral cavity. And the dorsalis pedis free skin flap has also the cosmetic advantage of the donor site.<BR>These functional and cosmetic restorations could facilitate the return to the social life of the patients.