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豊島 秀男 トヨシマ ヒデオ

所属部署名総合医学第1講座
職名准教授ホームページURL

プロフィール

研究分野

  • 生物科学 / 細胞生物学
  • 内科系臨床医学 / 代謝学

経歴

  • 1990年
    -
    1996年
     東京大学医学部 助手

学歴

  • -
    1985年
    東京大学 医学部 医(日本)

所属学協会

  • 日本糖尿病学会
  • 日本内分泌学会
  • 日本癌学会
  • 日本分子生物学会
  • 日本内科学会
所属学協会を全て表示する
所属学協会閉じる
  • 日本糖尿病学会
  • 日本内分泌学会
  • 日本癌学会
  • 日本分子生物学会
  • 日本内科学会

学位

  • 医学博士

研究活動

MISC

  • p57Kip2 is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor β1.
    URANO T, YASHIRODA H, MURAOKA M, TANAKA K, HOSOI T, INOUE S, OUCHI Y, TANAKA K, TOYOSHIMA H
    Journal of Biological Chemistry 274(18) 12197-12200 1999年
  • Inctivation of p27Kip1 by the viral E1A oncoprotein in TGF β-treated cells.
    MAL A, POON R Y C, HOWE P H, TOYOSHIMA H, HUNTER T, HARTER M L
    Nature 380(6571) 262-265 1996年
  • p27, a novelinhibitor of G1 cyclin-Cdk protein kinase activity, is related to P21.
    TOYOSHIMA H, HUNTER T
    Cell 78(1) 67-74 1994年
  • Role of cyclin A and p27 in anti-IgM-induced G1 growth arrest of murine B-cell lymphomas.
    Molecular Biology of the Cell 7 553-564 1996年
  • Cyclin-dependent Kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.
    POON R Y C, JIANG W, TOYOSHIMA H, HUNTER T
    Journal of Biological Chemistry 271(22) 13283-13291 1996年
  • Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.
    POON R Y C, JIANG W, TOYOSHIMA H, HUNTER T
    Journal of Biological Chemistry 271(22) 13283-13291 1996年
  • Redistribution of the CDK inhibitor p27 between different cyclin・CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.
    Molecular Biology of the Cell 6 1197-1213 1995年
  • Differently spliced cDNAs of human ltk receptor tyrosine kinase predict receptor proteins with and without tyrosine kinase domain and a soluble receptor protein.
    TOYOSHIMA H, KOZUTSUMI H, MARU Y, HAGIWARA K, FURUYA A, MIOH H, HANAI N, TAKAKU F, HIRAI H
    Proceedings of the National Academy of Sciences of the United States of America 90(12) 5404-5408 1993年
  • Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and trnsport of unspliced RNAs.
    Journal of Virology 64 2825-2832 1990年
  • Smad-mediated Transcription Is Required for Transforming Growth Factor-β1-induced p57Kip2 Proteolysis in Osteoblastic Cells
    NISHIMORI S, TANAKA Y, CHIBA T, FUJII M, MIYAZONO K, OGASAWARA T, KAWAGUCHI H, IGARASHI T, TOYOSHIMA H
    The Journal of Biological Chemistry 276(14) 10700-10705 2001年
論文等(その他)を全て表示する
論文等(その他)閉じる
  • p57Kip2 is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor β1.
    URANO T, YASHIRODA H, MURAOKA M, TANAKA K, HOSOI T, INOUE S, OUCHI Y, TANAKA K, TOYOSHIMA H
    Journal of Biological Chemistry 274(18) 12197-12200 1999年
  • Inctivation of p27Kip1 by the viral E1A oncoprotein in TGF β-treated cells.
    MAL A, POON R Y C, HOWE P H, TOYOSHIMA H, HUNTER T, HARTER M L
    Nature 380(6571) 262-265 1996年
  • p27, a novelinhibitor of G1 cyclin-Cdk protein kinase activity, is related to P21.
    TOYOSHIMA H, HUNTER T
    Cell 78(1) 67-74 1994年
  • Role of cyclin A and p27 in anti-IgM-induced G1 growth arrest of murine B-cell lymphomas.
    Molecular Biology of the Cell 7 553-564 1996年
  • Cyclin-dependent Kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.
    POON R Y C, JIANG W, TOYOSHIMA H, HUNTER T
    Journal of Biological Chemistry 271(22) 13283-13291 1996年
  • Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.
    POON R Y C, JIANG W, TOYOSHIMA H, HUNTER T
    Journal of Biological Chemistry 271(22) 13283-13291 1996年
  • Redistribution of the CDK inhibitor p27 between different cyclin・CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.
    Molecular Biology of the Cell 6 1197-1213 1995年
  • Differently spliced cDNAs of human ltk receptor tyrosine kinase predict receptor proteins with and without tyrosine kinase domain and a soluble receptor protein.
    TOYOSHIMA H, KOZUTSUMI H, MARU Y, HAGIWARA K, FURUYA A, MIOH H, HANAI N, TAKAKU F, HIRAI H
    Proceedings of the National Academy of Sciences of the United States of America 90(12) 5404-5408 1993年
  • Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and trnsport of unspliced RNAs.
    Journal of Virology 64 2825-2832 1990年
  • Smad-mediated Transcription Is Required for Transforming Growth Factor-β1-induced p57Kip2 Proteolysis in Osteoblastic Cells
    NISHIMORI S, TANAKA Y, CHIBA T, FUJII M, MIYAZONO K, OGASAWARA T, KAWAGUCHI H, IGARASHI T, TOYOSHIMA H
    The Journal of Biological Chemistry 276(14) 10700-10705 2001年

外部的資金

  • 動脈硬化における細胞分化と細胞周期
    :その他の研究制度
外部資金採択状況を全て表示する
外部資金採択状況閉じる
  • 動脈硬化における細胞分化と細胞周期
    :その他の研究制度


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