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木村 博昭 キムラ ヒロアキ

所属部署名博士課程地域医療学系専攻血液・免疫疾患学専攻分野炎症免疫学専攻科
職名講師ホームページURLhttp://kaken.nii.ac.jp/d/r/70593622.ja.html

プロフィール

研究キーワード

    メタボリック症候群, 動脈硬化, 免疫プロテアソーム, 自己免疫疾患, 肥満

研究分野

  • 基礎医学 / 免疫学 / 免疫プロテアソーム
  • 内科系臨床医学 / 内分泌学

経歴

  • 2010年06月
    自治医科大学 医学部(講師)
  • 2008年07月
    -
    2010年05月
    ジョーンズホプキンス大学 医学部病理(リサーチアソシエート)
  • 2001年07月
    -
    2008年06月
    ジョーンズホプキンス大学 医学部病理(ポスドク)
  • 1998年05月
    -
    2001年06月
    国立感染症研究所 ハンセン病研究センター(協力研究員)

学歴

  • -
    1998年05月
    名古屋市立大学大学院 薬学研究科

所属学協会

  • 日本内分泌学会
  • 日本甲状腺学会
  • 日本炎症・再生医学会
  • アメリカ内分泌学会
  • アメリカ甲状腺学会
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  • 日本内分泌学会
  • 日本甲状腺学会
  • 日本炎症・再生医学会
  • アメリカ内分泌学会
  • アメリカ甲状腺学会

学位

  • 薬学博士

研究活動

論文

  • Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
    Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M
    American journal of physiology. Endocrinology and metabolism 311(5) E881-E890 2016年11月
  • NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy.
    Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M
    Endocrinology 156(11) 4281-4292 2015年11月
  • NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity.
    Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y, Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M
    Scientific reports 6 2016年05月
  • Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders.
    Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M
    Scientific reports 5 2015年10月
  • Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury.
    Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M
    Scientific reports 5 2015年06月
  • Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing.
    Karasawa T, Kawashima A, Usui F, Kimura H, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Sagara J, Takahashi M
    FEBS open bio 5 348-356 2015年04月
  • Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
    Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M
    Arteriosclerosis, thrombosis, and vascular biology 35(1) 127-136 2015年01月
  • NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β.
    Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M
    The Journal of biological chemistry 290(8) 5065-5077 2015年02月
  • Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.
    Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M
    Nanotoxicology 9(5) 554-567 2015年
  • Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages.
    Hara K, Shirasuna K, Usui F, Karasawa T, Mizushina Y, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M
    PloS one 9(12) 2014年12月
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  • Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
    Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M
    American journal of physiology. Endocrinology and metabolism 311(5) E881-E890 2016年11月
  • NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy.
    Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M
    Endocrinology 156(11) 4281-4292 2015年11月
  • NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity.
    Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y, Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M
    Scientific reports 6 2016年05月
  • Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders.
    Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M
    Scientific reports 5 2015年10月
  • Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury.
    Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M
    Scientific reports 5 2015年06月
  • Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing.
    Karasawa T, Kawashima A, Usui F, Kimura H, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Sagara J, Takahashi M
    FEBS open bio 5 348-356 2015年04月
  • Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
    Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M
    Arteriosclerosis, thrombosis, and vascular biology 35(1) 127-136 2015年01月
  • NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β.
    Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M
    The Journal of biological chemistry 290(8) 5065-5077 2015年02月
  • Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.
    Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M
    Nanotoxicology 9(5) 554-567 2015年
  • Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages.
    Hara K, Shirasuna K, Usui F, Karasawa T, Mizushina Y, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M
    PloS one 9(12) 2014年12月
  • New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells.
    Kimura H, Caturegli P, Takahashi M, Suzuki K
    Journal of immunology research 2015 541984 2015年
  • ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction.
    Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M
    The American journal of pathology 184(5) 1287-1298 2014年05月
  • NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.
    Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 192(9) 4342-4351 2014年05月
  • [Research update on pathogenesis of autoimmune thyroid diseases].
    Suzuki K, Kawashima A, Kimura H
    Nihon rinsho. Japanese journal of clinical medicine 70(11) 1880-1884 2012年11月
  • Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice.
    Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Hida S, Sagara J, Taniguchi S, Takahashi M
    Biochemical and biophysical research communications 425(2) 162-168 2012年08月
  • Hürthle cells predict hypothyroidism in interferon-γ transgenic mice of different genetic backgrounds.
    Iwama S, De Remigis A, Bishop JA, Kimura HJ, Caturegli P
    Endocrinology 153(8) 4059-4066 2012年08月
  • Pituitary and systemic autoimmunity in a case of intrasellar germinoma.
    Gutenberg A, Bell JJ, Lupi I, Tzou SC, Landek-Salgado MA, Kimura H, Su J, Karaviti LP, Salvatori R, Caturegli P
    Pituitary 14(4) 388-394 2011年12月
  • Role of thyroglobulin on negative feedback autoregulation of thyroid follicular function and growth.
    Suzuki K, Kawashima A, Yoshihara A, Akama T, Sue M, Yoshida A, Kimura HJ
    The Journal of endocrinology 209(2) 169-174 2011年05月
  • Fragments of genomic DNA released by injured cells activate innate immunity and suppress endocrine function in the thyroid.
    Kawashima A, Tanigawa K, Akama T, Wu H, Sue M, Yoshihara A, Ishido Y, Kobiyama K, Takeshita F, Ishii KJ, Hirano H, Kimura H, Sakai T, Ishii N, Suzuki K
    Endocrinology 152(4) 1702-1712 2011年04月
  • Pregnancy, postpartum autoimmune thyroiditis, and autoimmune hypophysitis: intimate relationships.
    Landek-Salgado MA, Gutenberg A, Lupi I, Kimura H, Mariotti S, Rose NR, Caturegli P
    Autoimmunity reviews 9(3) 153-157 2010年01月
  • Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice.
    Kimura HJ, Chen CY, Tzou SC, Rocchi R, Landek-Salgado MA, Suzuki K, Kimura M, Rose NR, Caturegli P
    PloS one 4(11) 2009年11月
  • Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice.
    Usui F, Kimura H, Ohshiro T, Tatsumi K, Kawashima A, Nishiyama A, Iwakura Y, Ishibashi S, Takahashi M
    Biochemical and biophysical research communications 420(1) 72-77 2012年03月
  • Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development.
    Xiao Z, Mohamood AS, Uddin S, Gutfreund R, Nakata C, Marshall A, Kimura H, Caturegli P, Womer KL, Huang Y, Jie C, Chakravarti S, Schneck JP, Yagita H, Hamad AR
    The American journal of pathology 179(2) 725-732 2011年08月
  • Preparation of mouse pituitary immunogen for the induction of experimental autoimmune hypophysitis.
    Tzou SC, Landek-Salgado MA, Kimura H, Caturegli P
    Journal of visualized experiments : JoVE(46) 2010年12月
  • Induction of experimental autoimmune hypophysitis in SJL mice.
    Landek-Salgado MA, Tzou SC, Kimura H, Caturegli P
    Journal of visualized experiments : JoVE(46) 2010年12月
  • Excess iodide decreases transcription of NIS and VEGF genes in rat FRTL-5 thyroid cells.
    Suzuki K, Kimura H, Wu H, Kudo N, Kim WB, Suzuki S, Yoshida A, Caturegli P, Kohn LD
    Biochemical and biophysical research communications 393(2) 286-290 2010年03月
  • A nonclassical model of autoimmune hypothyroidism.
    Caturegli P, Kimura H
    Thyroid : official journal of the American Thyroid Association 20(1) 3-5 2010年01月
  • Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome.
    Vosters JL, Landek-Salgado MA, Yin H, Swaim WD, Kimura H, Tak PP, Caturegli P, Chiorini JA
    Arthritis and rheumatism 60(12) 3633-3641 2009年12月
  • Influence of signal transducer and activator of transcription-1 signaling on thyroid morphology and function.
    Kimura HJ, Rocchi R, Landek-Salgado MA, Suzuki K, Chen CY, Kimura M, Rose NR, Caturegli P
    Endocrinology 150(7) 3409-3416 2009年07月
  • Regenerative potentials of the murine thyroid in experimental autoimmune thyroiditis: role of CD24.
    Chen CY, Kimura H, Landek-Salgado MA, Hagedorn J, Kimura M, Suzuki K, Westra W, Rose NR, Caturegli P
    Endocrinology 150(1) 492-499 2009年01月
  • Pituitary autoimmunity: 30 years later.
    Caturegli P, Lupi I, Landek-Salgado M, Kimura H, Rose NR
    Autoimmunity reviews 7(8) 631-637 2008年09月
  • Autoimmune hypophysitis of SJL mice: clinical insights from a new animal model.
    Tzou SC, Lupi I, Landek M, Gutenberg A, Tzou YM, Kimura H, Pinna G, Rose NR, Caturegli P
    Endocrinology 149(7) 3461-3469 2008年07月
  • Chemokine orchestration of autoimmune thyroiditis.
    Kimura H, Caturegli P
    Thyroid : official journal of the American Thyroid Association 17(10) 1005-1011 2007年10月
  • Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness.
    Rocchi R, Kimura H, Tzou SC, Suzuki K, Rose NR, Pinchera A, Ladenson PW, Caturegli P
    Proceedings of the National Academy of Sciences of the United States of America 104(14) 6019-6024 2007年04月
  • Autoimmune thyroid diseases.
    Caturegli P, Kimura H, Rocchi R, Rose NR
    Current opinion in rheumatology 19(1) 44-48 2007年01月
  • Multiple mechanisms involved in the inhibition of proinflammatory cytokine production from human monocytes by N-(p-coumaroyl)serotonin and its derivatives.
    Takii T, Kawashima S, Chiba T, Hayashi H, Hayashi M, Hiroma H, Kimura H, Inukai Y, Shibata Y, Nagatsu A, Sakakibara J, Oomoto Y, Hirose K, Onozaki K
    International immunopharmacology 3(2) 273-277 2003年02月
  • IL-12 overexpression in mice as a model for Sjögren lung disease.
    McGrath-Morrow S, Laube B, Tzou SC, Cho C, Cleary J, Kimura H, Rose NR, Caturegli P
    American journal of physiology. Lung cellular and molecular physiology 291(4,Pt.1) 837-846 2006年10月
  • Interleukin (IL)-12-driven primary hypothyroidism: the contrasting roles of two Th1 cytokines (IL-12 and interferon-gamma).
    Kimura H, Tzou SC, Rocchi R, Kimura M, Suzuki K, Parlow AF, Rose NR, Caturegli P
    Endocrinology 146(8) 3642-3651 2005年08月
  • Increased thyroidal fat and goitrous hypothyroidism induced by interferon-gamma.
    Kimura H, Kimura M, Westra WH, Rose NR, Caturegli P
    International journal of experimental pathology 86(2) 97-106 2005年04月
  • Expression of class II major histocompatibility complex molecules on thyrocytes does not cause spontaneous thyroiditis but mildly increases its severity after immunization.
    Kimura H, Kimura M, Tzou SC, Chen YC, Suzuki K, Rose NR, Caturegli P
    Endocrinology 146(3) 1154-1162 2005年03月
  • Early chemokine expression induced by interferon-gamma in a murine model of Hashimoto's thyroiditis.
    Kimura H, Kimura M, Rose NR, Caturegli P
    Experimental and molecular pathology 77(3) 161-167 2004年12月
  • Studies on murine thyroiditis: new insights from organ flow cytometry.
    Caturegli P, Rose NR, Kimura M, Kimura H, Tzou SC
    Thyroid : official journal of the American Thyroid Association 13(5) 419-426 2003年05月
  • Mycobacterium leprae infection in monocyte-derived dendritic cells and its influence on antigen-presenting function.
    Hashimoto K, Maeda Y, Kimura H, Suzuki K, Masuda A, Matsuoka M, Makino M
    Infection and immunity 70(9) 5167-5176 2002年09月
  • Interaction of Neutrophils with Macrophages Promotes IL-1β Maturation and Contributes to Hepatic Ischemia–Reperfusion Injury
    Ai Sadatomo, Yoshiyuki Inoue, Homare Ito, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Yoshiko Mizushina, Jun Nakamura, Ryo Kamata, Tadashi Kasahara, Hisanaga Horie, Naohiro Sata, Masafumi Takahashi
    The Journal of Immunology 199(9) 3306 2017年11月
  • ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages
    Akira Kawashima, Tadayoshi Karasawa, Kenji Tago, Hiroaki Kimura, Ryo Kamata, Fumitake Usui-Kawanishi, Sachiko Watanabe, Satoshi Ohta, Megumi Funakoshi-Tago, Ken Yanagisawa, Tadashi Kasahara, Koichi Suzuki, Masafumi Takahashi
    The Journal of Immunology 199(10) 3614 2017年11月
  • The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction.
    PloS one 2017年
  • NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β.
    Yamasawa H., Mato N., Iwakura Y., Latz E., Bando M., Kasahara T., Takahashi M., Sugiyama Y., Mizushina Y., Usui F., Shirasuna K., Kawashima A., Karasawa T., Kobayashi M., Kimura H., Inoue Y., Komada T.
    The Journal of biological chemistry 290(8) 5065-5077 2015年02月
  • Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
    Sagara J., Noda T., Takahashi M., Taniguchi S., Usui F., Kimura H., Shirasuna K., Kawashima A., Tatsumi K., Yoshimura K., Karasawa T., Tsutsui H., Aoki H.
    Arteriosclerosis, thrombosis, and vascular biology 35(1) 127-136 2015年01月
  • Role of thyroglobulin on negative feedback autoregulation of thyroid follicular function and growth.
    SUZUKI Koichi, KAWASHIMA Akira, YOSHIHARA Aya, AKAMA Takeshi, SUE Mariko, YOSHIDA Akio, KIMURA Hiroaki J
    The Journal of endocrinology 209(2) 169-174 2011年05月
  • Application of innate immune molecules for a new class of drugs: infection, inflammation and beyond.
    Endocrine, metabolic & immune disorders drug targets 2011年03月
  • Tryptophan aspartate-containing coat protein (CORO1A) suppresses Toll-like receptor signalling in Mycobacterium leprae infection.
    ISHII N, KAWASHIMA A, AKAMA T, WU H, TAKESHITA F, KIMURA H, SUZUKI K, TANIGAWA K
    Clinical and experimental immunology 156(3) 495-501 2009年06月
  • Autoimmune thyroid diseases.
    Current opinion in rheumatology 2007年01月
  • Upregulation of T-cell-stimulating activity of mycobacteria-infected macrophages.
    KIMURA H, MAEDA Y, TAKESHITA F, TAKAOKA Le, MATSUOKA M, MAKINO M
    Scandinavian journal of immunology 60(3) 278-286 2004年09月
  • Multidrug resistant Mycobacterium leprae from patients with leprosy.
    MAEDA S, MATSUOKA M, NAKATA N, KAI M, MAEDA Y, HASHIMOTO K, KIMURA H, KOBAYASHI K, KASHIWABARA Y
    Antimicrobial agents and chemotherapy 45(12) 3635-3639 2001年12月
  • Molecular analysis of constitutive IL-1alpha gene expression in human melanoma cells: autocrine stimulation through NF-kappaB activation by endogenous IL-1alpha.
    KIMURA H, INUKAI Y, TAKII T, FURUTANI Y, SAKURADA S, OKAMOTO T, INOUE J‐I, OOMOTO Y, ONOZAKI K
    Cytokine 10(11) 872-879 1998年11月
  • Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 by endotoxin-stimulated human blood monocytes.
    KAWASHIMA S, TAKII T, KIMURA H, ZHANG H L, NAGATSU A, SAKAKIBARA J, MURATA K, OOMOTO Y, ONOZAKI K
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 18(6) 423-428 1998年06月
  • Type I and type II interferons upregulate functional type I interleukin-1 receptor in a human fibroblast cell line TIG-1.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995年12月

受賞

  • 2008年07月 アメリカ甲状腺学会 アメリカ甲状腺学会グラント2008
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  • 2008年07月 アメリカ甲状腺学会 アメリカ甲状腺学会グラント2008


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