研究者総覧

木下 望 (キノシタ ノゾミ)

  • 総合医学第2講座 講師
Last Updated :2020/07/29

研究者情報

学位

  • 博士(医学)(2006年12月 自治医科大学)
  • 医師免許(1995年04月 自治医科大学)

学位

    木下 望

論文上での記載著者名

  • Nozomi Kinoshita

ホームページURL

科研費研究者番号

  • 00382846

ORCID ID

J-Global ID

プロフィール

  • 私は中学1年生の時に、近視になりました。近視を治したくて、遠くの山を見たり、目の体操をしたり、超音波治療器を親に買ってもらったりしましたが、治りませんでした。
    そこで将来眼科医になって近視の研究をしようと思い立ち、医師になることにしました。眼科医になってから、本当に怖いのは強度近視であることを知りました。強度近視は、眼軸長が長くなり過ぎたため網膜が引き伸ばされ萎縮してしまい失明原因になります。そして近視の発症年齢が低いほど、この強度近視になりやすくなります。
    このたび日本学術振興会(文部科学省)より、近視進行(=眼軸長伸展)抑制治療の研究に対し、科学研究費を助成して戴くことになりました。不運にも幼くして近視になってしまった子供たちを将来強度近視にさせないことが、私の使命と肝に銘じ研究に打ち込む所存です。
    皆様のご支援に感謝しつつ頑張りますので、今後ともご協力の程、宜しくお願い致します。

研究キーワード

  • 近視進行抑制   近視進行予防   0.01%アトロピン点眼液   眼軸長伸展抑制   糖尿病網膜症   網膜微小循環障害   近視   オルソケラトロジー   低濃度アトロピン点眼液   相加効果   併用治療   

研究分野

  • ライフサイエンス / 眼科学

経歴

  • 2012年12月 - 現在  自治医科大学附属さいたま医療センター眼科講師
  • 2004年05月 - 2012年11月  自治医科大学附属さいたま医療センター眼科助教
  • 2002年05月 - 2004年04月  公立和田山病院眼科医長
  • 2000年05月 - 2002年04月  自治医科大学附属大宮医療センター眼科後期研修医
  • 1998年05月 - 2000年04月  公立村岡病院内科医員
  • 1997年05月 - 1998年04月  美方町国保大谷診療所所長
  • 1995年05月 - 1997年04月  兵庫県立淡路病院スーパーローテーション前期研修医

学歴

  • 1989年04月 - 1995年03月   自治医科大学   医学部   医学科
  • 1986年04月 - 1989年03月   兵庫県立豊岡高等学校   理数コース

所属学協会

  • 近視研究会   埼玉県眼科医会   日本眼科医会   日本眼科学会   American Academy of Ophthalmology   The Association for Research in Vision and Ophthalmology   

研究活動情報

論文

  • Efficacy of combined orthokeratology and 0.01% atropine solution for slowing axial elongation in children with myopia: a 2-year randomised trial
    Nozomi Kinoshita, Yasuhiro Konno, Naoki Hamada, Yoshinobu Kanda, Machiko Shimmura-Tomita, Toshikatu Kaburaki, Akihiro Kakehashi
    Scientific Reports 10 in press  2020年07月 [査読有り][通常論文]
  • Nozomi Kinoshita, Yasuhiro Konno, Naoki Hamada, Yoshinobu Kanda, Machiko Shimmura-Tomita, Akihiro Kakehashi
    Japanese Journal of Ophthalmology 62 5 544 - 553 2018年09月 [査読有り][通常論文]
  • Ota A, Tanaka Y, Toyoda F, Shimmura M, Kinoshita N, Takano H, Kakehashi A
    Clinical ophthalmology (Auckland, N.Z.) 10 7 - 11 2016年 [査読有り][通常論文]
  • Fumihiko Toyoda, Yoshiaki Tanaka, Machiko Shimmura, Nozomi Kinoshita, Hiroko Takano, Akihiro Kakehashi
    JOURNAL OF DIABETES RESEARCH 2016 2345141  2016年 [査読有り][通常論文]
     
    We evaluated the features of diabetic retinal and choroidal edema in Spontaneously Diabetic Torii (SDT) rats. We measured the retinal and choroidal thicknesses in normal Sprague-Dawley (SD) rats (n = 9) and SDT rats (n = 8). The eyes were enucleated 40 weeks later after they were diagnosed with diabetes, and 4-micron sections were cut for conventional histopathologic studies. The mean retinal and choroidal thicknesses were significantly thicker in the SDT rats than in the normal SD rats. The choroidal thickness was correlated strongly with the retinal thickness in both rat models. Diabetic retinopathy (DR) and diabetic choroidopathy appeared as edema in the SDT rats. The retinal thickness was correlated strongly with the choroidal thickness in the SDT rats, which is an ideal animal model of both DR and choroidopathy.
  • Kenshiro Arao, Asuka Kuribara, Hiroyuki Jinnouchi, Mitsunari Matsumoto, Takayuki Fujiwara, Nozomi Kinoshita, Akihiro Kakehashi, Junya Ako, Shin-ichi Momomura
    OPHTHALMOLOGY 121 11 2261 - 2267 2014年11月 [査読有り][通常論文]
     
    Purpose: To explore the occurrence of transient retinopathy and its prognostic importance in patients with acute aortic dissection (AAD). Design: Prospective, observational study. Participants: Sixty-four patients with Stanford type B AAD were treated with conservative medical therapy. Methods: Retinopathy findings, such as cotton-wool spots and hemorrhage, were examined. Fundus photography was performed on hospital days 9 to 14 and after 2 or 3 months. The association between the appearance of retinopathy and the subsequent cardio-cerebrovascular events was investigated. Main Outcome Measures: The primary outcomes included the incidence of retinopathy and subsequent adverse cardio-cerebrovascular events. Results: Retinopathy was detected in 55% (35 of 64) of patients (cotton-wool spots alone, n = 31; dot hemorrhage alone, n = 1; and both, n = 3). These findings disappeared in all 12 patients who underwent follow-up fundus examinations. In the multivariate analysis, a history of hypertension and higher peak C-reactive protein level were independently associated with retinopathy. At a median follow-up of 911 days, adverse cardiocerebrovascular events were reported in 11 patients, of whom those with retinopathy experienced adverse events significantly more frequently than those without retinopathy (P = 0.045). Conclusions: Retinopathy occurred frequently in patients with AAD. This retinopathy was associated with a history of hypertension and higher peak C-reactive protein levels and was an important predictive factor for adverse cardio-cerebrovascular outcomes. (C) 2014 by the American Academy of Ophthalmology.
  • Fumihiko Toyoda, Yoshiaki Tanaka, Ayumi Ota, Machiko Shimmura, Nozomi Kinoshita, Hiroko Takano, Takafumi Matsumoto, Junichi Tsuji, Akihiro Kakehashi
    JOURNAL OF DIABETES RESEARCH 2014 672590  2014年 [査読有り][通常論文]
     
    Purpose. To evaluate the effect of ranirestat, a new aldose reductase inhibitor (ARI), on diabetic retinopathy (DR) in Spontaneously Diabetic Torii (SDT) rats. Methods. The animals were divided into six groups, normal Sprague-Dawley rats (n = 8), untreated SDT rats (n = 9), ranirestat-treated SDT rats (0.1, 1.0, and 10 mg/kg/day, n = 7,8, and 6, resp.), and epalrestat-treated SDT rats (100mg/kg/day, n = 7). Treated rats received oral ranirestat or epalrestat once daily for 40 weeks after the onset of diabetes. After the eyes were enucleated, the retinal thickness and the area of stained glial fibrillary acidic protein (GFAP) were measured. Results. The retinas in the untreated group were significantly thicker than those in the normal and ranirestat-treated (0.1, 1.0, and 10mg/kg/day) groups. The immunostained area of GFAP in the untreated group was significantly larger than that in the normal and ranirestat-treated (1.0 and 10mg/kg/day) groups. There were no significant differences between the untreated group and epalrestat-treated group in the retinal thickness and the area of stained GFAP. Conclusion. Ranirestat reduced the retinal thickness and the area of stained GFAP in SDT rats and might suppress DR and have a neuroprotective effect on diabetic retinas.
  • Ayumi Ota, Akihiro Kakehashi, Fumihiko Toyoda, Nozomi Kinoshita, Machiko Shinmura, Hiroko Takano, Hiroto Obata, Takafumi Matsumoto, Junichi Tsuji, Yoh Dobashi, Wilfred Y. Fujimoto, Masanobu Kawakami, Yasunori Kanazawa
    JOURNAL OF DIABETES RESEARCH 2013 175901  2013年 [査読有り][通常論文]
     
    We evaluated ranirestat, an aldose reductase inhibitor, in diabetic cataract and neuropathy (DN) in spontaneously diabetic Torii (SDT) rats compared with epalrestat, the positive control. Animals were divided into groups and treated once daily with oral ranirestat (0.1, 1.0, 10 mg/kg) or epalrestat (100 mg/kg) for 40 weeks, normal Sprague-Dawley rats, and untreated SDT rats. Lens opacification was scored from 0 (normal) to 3 (mature cataract). The combined scores (0-6) from both lenses represented the total for each animal. DN was assessed by measuring the motor nerve conduction velocity (MNCV) in the sciatic nerve. Sorbitol and fructose levels were measured in the lens and sciatic nerve 40 weeks after diabetes onset. Cataracts developed more in untreated rats than normal rats (P < 0.01). Ranirestat significantly (P < 0.01) inhibited rapid cataract development; epalrestat did not. Ranirestat significantly reversed the MNCV decrease (40.7 +/- 0.6 m/s) in SDT rats dose-dependently (P < 0.01). Epalrestat also reversed the prevented MNCV decrease (P < 0.05). Sorbitol levels in the sciatic nerve increased significantly in SDT rats (2.05 +/- 0.10 nmol/g), which ranirestat significantly suppressed dose-dependently, (P < 0.05, < 0.01, and < 0.01); epalrestat did not. Ranirestat prevents DN and cataract; epalrestat prevents DN only.
  • Kinoshita N, Ota A, Toyoda F, Yamagami H, Kakehashi A
    Clinical ophthalmology (Auckland, N.Z.) 6 915 - 918 2012年06月 [査読有り][通常論文]
  • Kinoshita N, Ota A, Toyoda F, Yamagami H, Kakehashi A
    Clinical ophthalmology (Auckland, N.Z.) 5 1777 - 1781 2011年12月 [査読有り][通常論文]
  • Kakehashi A, Takezawa M, Toyoda F, Kinoshita N, Kambara C, Yamagami H, Kato N, Ishikawa S, Kawakami M, Kanazawa Y
    Open Diabetes J 4 101 - 107 2011年03月 [査読有り][通常論文]
  • Toyoda F, Kakehashi A, Ota A, Kinoshita N, Ueba H, Dobashi Y, Ishikawa S, Kawakami M, Kanazawa Y
    Open Diabetes J 4 108 - 113 2011年03月 [査読有り][通常論文]
  • Toyoda F, Kakehashi A, Hashimoto K, Kinoshita N, Kambara C, Yamagami H, Tamemoto H, Ishikawa S, Dobashi Y, Kawakami M, Kanazawa Y
    Open Diabetes J 4 41 - 44 2011年03月 [査読有り][通常論文]
  • Kinoshita N, Kakehashi A, Dobashi Y, Ono R, Toyoda F, Kambara C, Yamagami H, Kitazume Y, Kobayashi E, Osakabe Y, Kudo M, Kawakami M, Kanazawa Y
    Open Diabetes J 4 114 - 118 2011年03月 [査読有り][通常論文]
  • Takuji Katayama, Takanori Yasu, Nozomi Kinoshita, Akihiro Kakehashi, Norifumi Kubo, Muneyasu Saito, Shin-ichi Momomura, Masanobu Kawakami
    CIRCULATION JOURNAL 73 7 1278 - 1282 2009年07月 [査読有り][通常論文]
     
    Background: A unique transient retinopathy characterized by soft exudates around the optic disc after percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) has been reported, so in the present study the risk factors for retinopathy associated with AMI (RAMI) were investigated. Methods and Results: The study group comprised 62 patients with their first AMI who underwent successful PCI within 24h of onset (48 men, 14 women; age 63 +/- 10 years). The fundus of each eye was assessed on days 3-5, and again at 4 weeks after AMI onset. New soft exudates developed in 29 patients (47%) at 4 weeks. The frequency of diabetes mellitus (DM), and the hemoglobin A(1c) and peak creatine kinase concentrations were higher in patients with than in those without RAMI (55% vs 21%, P=0.008; 7.0 +/- 2.0% vs 5.9 +/- 1.4%, P=0.013; and 3,428 +/- 2,210 IU/L vs 2,352 +/- 1,652 IU/L, P=0.036, respectively). Multivariate analysis identified DM as an independent predictive factor for the occurrence of RAMI (odds ratio, 6.60-, 95% confidence interval, 1.68-25.90; P=0.007). Conclusions: DM might be a risk factor for RAMI. (Circ J 2009; 73: 1278-1282)
  • 網膜微小循環障害に起因する網膜症の検討(学位論文)
    木下 望
    自治医科大学 2006年12月 [査読有り][通常論文]
  • Ono R, Kakehashi A, Yamagami H, Sugi N, Kinoshita N, Saito T, Tamemoto H, Kuroki M, Lshikawa SE, Kawakami M
    International ophthalmology 26 1 15 - 19 1-2 2005年02月 [査読有り][通常論文]
  • K Kasono, T Yasu, A Kakehashi, N Kinoshita, H Tamemoto, K Namai, R Ohn, H Ueba, M Kuroki, S Ishikawa, M Kawakami
    EUROPEAN JOURNAL OF ENDOCRINOLOGY 151 2 277 - 285 2004年08月 [査読有り][通常論文]
     
    Objective: N-(2-hydroxyethyl)-nicotinamide nitrate (nicorandil) is a unique anti-anginal agent, reported to act as both an ATP-sensitive K+ channel opener (PCO) and a nitric oxide donor. It also has an anti-oxidant action. We examined the effects of nicorandil on streptozotocin (STZ)-induced islet beta-cell damage both in vivo and in vitro. Design and methods: STZ-induced diabetic Brown Norway rats (STZ-DM) were fed with nicorandil-containing chow from day 2 (STZ-DM-N48). 3 (STZ-DM-N72), and 4 (STZ-DM-N96) to day 30. Body weight, blood glucose, and plasma insulin were measured every week. For the in vitro assay, neonatal rat islet-rich cultures were performed and cells were treated with nicorandil from 1 h before to 2 h after exposure to STZ for 30 min. Insulin secretion from islet cells was assayed after an additional 24 h of culture. We also observed the effect of nicorandil on the generation of reactive oxygen species (ROS) from rat inslinoma cells (RINm5F). Results: Body weight loss and blood glucose levels of STZ-DM-N48 rats were significantly lower than those of STZ-DM rats. Immunohistochemical staining of insulin showed preservation of insulin-secreting islet beta-cells in STZ-DM-N48 rats. Nicorandil also dose-dependently recovered the insulin release from neonatal rat islet cells treated with STZ in in vitro experiments. Nicorandil did not act as a PCO on neonatal rat islet beta-cells or RINm5F cells, and did not show an inhibitory effect on poly( ADP-ribose) polymerase-1. However, the drug inhibited the production of ROS stimulated by high glucose (22.0 mmol/l) in RINm5F cells. Conclusions: These results suggested that nicorandil improves diabetes and rat islet beta-cell damage induced by STZ in vivo and in vitro. It protects islet beta-cells, at least partly, via a radical scavenging effect.
  • N Kinoshita, A Kakehashi, T Yasu, T Katayama, M Kuroki, Y Tsurimaki, R Ono, H Yamagami, M Saito, M Kawakami
    BRITISH JOURNAL OF OPHTHALMOLOGY 88 4 494 - 496 2004年04月 [査読有り][通常論文]
     
    Aim: To report a new form of retinopathy that was observed in patients who had undergone percutaneous coronary intervention (PCI) following acute myocardial infarction (AMI). Methods: Serial ophthalmological examinations were conducted in 40 patients who underwent PCI. Thirty patients were diagnosed with AMI, and another 10 had stable angina pectoris. Results: Cotton wool spots developed in 17 (57%) patients from the group with AMI undergoing PCI (n = 30) within 2 months. Of these, 41% ( seven patients) also developed superficial haemorrhages. Retinopathy was most prominent 1 - 2 months after AMI and then tended to become quiescent afterwards, without treatment. Conclusion: We have identified a new form of retinopathy in patients with AMI that spontaneously subsides without treatment.
  • [Transient retinopathy after acute myocardial infarction treated by reperfusion therapy: clinical background and manifestation].
    Katayama T, Yasu T, Kinoshita N, Kakehashi A, Ueba H, Hashimoto S, Kobayashi N, Tsuruya Y, Kubo N, Fujii M, Kuroki M, Kawakami M, Saito M
    Journal of cardiology 42 1 23 - 28 1 2003年07月 [査読有り][通常論文]
  • N Kinoshita, A Kakehashi, S Inoda, Y Itou, M Kuroki, T Yasu, M Kawakami, Y Kanazawa
    DIABETOLOGIA 45 5 735 - 739 2002年05月 [査読有り][通常論文]
     
    Aims/hypothesis. Early stage leukocyte entrapment in the retinal microcirculation (retinal leukostasis) is considered to be one of the important pathogenetic events in diabetic retinopathy. Gliclazide, a sulphonylurea, was reported to reduce leukocyte adhesion to endothelial cells in hyperglycaemia in vitro, thus suggesting possible selective efficacy of this sulphonylurea in preventing leukostasis in diabetic patients. This study evaluated the effectiveness and selectivity of gliclazide treatment on retinal leukostasis of diabetic rats in vivo. Methods. Streptozotocin (STZ) (65 mg/kg)-induced diabetic rats were divided into three groups (n = 8 each): an untreated diabetic group, a gliclazide-treated diabetic group, and a glibenclamide-treated diabetic group. Gliclazide or glibenclamide was administered orally during a 3-week period. Non-diabetic rats were used as a control (n = 8). Retinal leukostasis was quantitatively evaluated in vivo by acridine orange T leukocyte fluorography using a scanning laser ophthalmoscope. Results. The number of leukocytes trapped in the area around the optic disc in the untreated diabetic group (36.9 +/- 5.1 cells) increased significantly compared with the non-diabetic control group (21.9 +/- 2.9 cells; p = 0.0007). The number of leukocytes trapped in the gliclazide-treated diabetic group (23.5 +/- 4.0 cells) decreased significantly compared with untreated diabetic group (p = 0.0008). In contrast, no reduction of retinal leukostasis was found in the glibenclamide-treated diabetic group (37.8 +/- 5.8 cells; p = 0.7923). Conclusion/interpretation. This suggests that gliclazide could directly improve abnormalities in the retinal microcirculation independent of blood glucose control and possibly have selective therapeutic benefits in preventing early, critical events in diabetic retinopathy compared with other sulphonylurea drugs.

書籍

  • 特集:近視
    木下 望 (担当:分担執筆範囲:オルソケラトロジーと低濃度アトロピン点眼液の併用による近視進行予防)
    視覚の科学第40巻第4号/中西印刷(株) 2019年12月 4 95-98
  • 子どもの近視進行を予防し、子どもの近視を減らす!
    木下 望 (担当:分担執筆範囲:近視進行を点眼で予防する)
    眼科グラフィック2019年6号/メディカ出版 2019年11月 ISBN: 9784840468381 5 P651-655

講演・口頭発表等

MISC

  • 木下 望, 今野泰宏, 濱田直紀, 榛村真智子, 梯彰弘 第73回日本臨床眼科学会プログラム講演抄録集 71 2019年10月 [査読有り][通常論文]
  • Kinoshita N, Konno Y, Hamada N, Shimmura-Tomita M, Kakehashi A AAO Meeting Archives 2019年10月 [査読有り][通常論文]
  • Kinoshita N, Konno Y, Hamada N, Kakehashi A Invest Ophthalmol Vis Sci 58 2386 2017年06月 [査読有り][通常論文]
  • 木下望, 今野泰宏, 濱田直紀, 梯彰弘 第70回日本臨床眼科学会プログラム講演抄録集 134 2016年10月 [査読有り][通常論文]
  • Corneal epithelium wound healing and chronological change of cornea in a spontaneous type 2 diabetes model rat
    Machiko Shimmura-Tomita, Hiroko Takano, Nozomi Kinoshita, Fumihiko Toyoda, Ayumi Ota, Yoshiaki Tanaka, Shiho Uehara, Akihiro Kakehashi INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 56 (7) 2015年06月 [査読無し][通常論文]
  • 太田有夕美, 豊田文彦, 竹澤美貴子, 榛村真智子, 木下望, 高野博子, 手塚聡一, 梯彰弘 眼科臨床紀要 7 (5) 382 2014年05月 [査読無し][通常論文]
  • 榛村真智子, 高野博子, 木下望, 豊田文彦, 太田有夕美, 田中克明, 梯彰弘 日本眼科学会雑誌 118 315 2014年03月 [査読無し][通常論文]
  • 高野博子, 太田有夕美, 田中克明, 豊田文彦, 榛村真智子, 木下望, 梯彰弘 日本角膜学会総会・日本角膜移植学会プログラム・抄録集 38th-30th 108 2014年 [査読無し][通常論文]
  • 榛村真智子, 高野博子, 木下望, 豊田文彦, 太田有夕美, 田中克明, 梯彰弘 日本角膜学会総会・日本角膜移植学会プログラム・抄録集 38th-30th 74 2014年 [査読無し][通常論文]
  • 高野博子, 當重遼子, 太田有夕美, 豊田文彦, 榛村真智子, 木下望, 梯彰宏 日本角膜学会総会・日本角膜移植学会プログラム・抄録集 37th-29th 114 2013年 [査読無し][通常論文]
  • 高野博子, 當重遼子, 太田有夕美, 豊田文彦, 榛村真智子, 木下望, 悌彰弘 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集 50th-47th-56th-2nd 66 2013年 [査読無し][通常論文]
  • 山上博子, 太田有夕美, 豊田文彦, 木下望, 梯彰弘 日本角膜学会総会・日本角膜移植学会プログラム・抄録集 36th-28th 68 2012年 [査読無し][通常論文]
  • 梯彰弘, 太田有夕美, 豊田文彦, 木下望, 山上博子, 小幡博人, 松本考史, 辻淳一, 土橋洋, 川上正舒, 金澤康徳 糖尿病合併症 25 (Supplement 1) 81 2011年09月 [査読無し][通常論文]
  • 太田有夕美, 梯彰弘, 豊田文彦, 木下望, 山上博子, 小幡博人, 松本考史, 辻淳一, 山上聡, 土橋洋, 川上正舒, 金澤康徳 日本糖尿病眼学会総会講演抄録集 17th 135 2011年 [査読無し][通常論文]
  • 木下望, 太田有夕美, 豊田文彦, 神原千浦, 山上博子, 梯彰弘 眼科手術 24 134 2010年12月 [査読有り][通常論文]
  • Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Retinopathy and Neuropathy in Spontaneously Diabetic Toni Rats
    Akihiro Kakehashi, Mikiko Takezawa, Fumihiko Toyoda, Nozomi Kinoshita, Chiho Kambara, Hiroko Yamagami, Hiroto Obata, Takafumi Matsumoto, Junichi Tsuji, Hiroshi Dobashi, Masanobu Kawakami, Yasunori Kanazawa DIABETES 59 (Suppl-1) A273 -A273 2010年06月 [査読無し][通常論文]
  • Kinoshita N, Kakehashi A, Toyoda F, Ishizaki K, Mameuda C, Yamagami H Invest Ophthalmol Vis Sci 49 5977 2008年05月 [査読有り][通常論文]
  • 太田 康, 椿 恵樹, 金澤 丈治, 山本 昌範, 児玉 梢, 飯野 ゆき子, 木下 望, 斉藤 由香, 豆生田 千浦, 山上 博子, 梯 彰弘 あたらしい眼科 = Journal of the eye 24 (9) 1223 -1228 2007年09月 [査読無し][通常論文]
  • Effects of topical nipradilol on early diabetic retinopathy in SDT rats
    Akihiro Kakehashi, Ryuichiro Ono, Nozomi Kinoshita, Kozue Ishizaki, Fumihiko Toyoda, Chino Mameuda, Hiroko Yamagami, Yusuke Kitazume, Takashi Nakamura, Eiji Kobayashi, Masanobu Kawakami, Yasunori Kanazawa DIABETES 56 A215 -A216 2007年06月 [査読無し][通常論文]
  • Diabetes mellitus and high peak creatine kinase are risk factors of the retinopathy associated with acute myocardial infarction
    Takuji Katayama, Takanori Yasu, Nozomi Kinoshita, Akihiro Kakehashi, Norifumi Kubo, Shinichi Momomura, Muneyasu Saito, Masanobu Kawakami CIRCULATION 114 (18) 738 -738 2006年10月 [査読無し][通常論文]
  • Renal function affects vitreous level of stromal-derived factor 1 in patients with diabetic retinopathy
    Akihiro Kakehashi, Chiho Mameuda, Hiroyuki Tamemoto, Nozomi Kinoshita, Hiroko Yamagami, San-E Ishikawa, Masanobu Kawakami DIABETES 55 A193 -A193 2006年06月 [査読無し][通常論文]
  • Accumulation of ages and VEGF expression in eyes of SDT rats
    A Kakehashi, K Mori, N Kinoshita, H Yamagami, M Shimohara, M Kawakami, Y Kanazawa, Y Kanazawa INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 46 2005年 [査読無し][通常論文]
  • Gliclazide prevents progression of diabetic retinopathy in SDT rats independent of blood glucose level
    A Kakehashi, K Mori, N Kinoshita, H Yamagami, M Kawakami, Y Kanazawa DIABETES 54 A558 -A558 2005年 [査読無し][通常論文]
  • Prevention of diabetic retinopathy in spontaneously diabetic torii rats by a sulfonylurea, gliclazide, independent of blood glucose level
    K Mori, A Kakehashi, N Kinoshita, H Yamagami, M Kawakami, Y Kanazawa INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 46 2005年 [査読無し][通常論文]
  • Effect of nicorandil on retinal microcirculation in streptozotocin-induced diabetic rats
    N Sugi, A Kakehashi, Y Saito, R Ohno, N Kinoshita, S Makino, T Yasu, M Kuroki, K Kasono, M Kawakami INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 45 U84 -U84 2004年04月 [査読無し][通常論文]
  • Progression of posterior vitreous detachment aids prognosis of diabetic retinopathy.
    A Kakehashi, R Ohno, H Yamagami, Y Ito, N Kinoshita, N Sugi, K Namai, K Kasono, H Tamemoto, M Kuroki, SE Ishikawa, M Kawakami DIABETOLOGIA 46 A393 -A393 2003年08月 [査読無し][通常論文]
  • 片山 卓志, 安 隆則, 木下 望, 梯 彰弘, 上羽 洋人, 橋本 重正, 小林 信彦, 鶴谷 善夫, 久保 典史, 藤井 幹久, 黒木 昌寿, 川上 正舒, 齋藤 宗靖 Journal of cardiology 42 (1) 23 -28 2003年07月 [査読無し][通常論文]
  • Suppressive effect of gliclazide on leukocyte involvement into microvessels subjected to ischemia/reperfusion in streptozotocin-induced diabetic rats
    T Yasu, A Kakehashi, N Kinoshita, N Ikeda, Y Ito, Y Kanazawa, M Kuroki, M Saito, M Kawakami CIRCULATION 106 (19) 271 -271 2002年11月 [査読無し][通常論文]
  • 心筋梗塞関連網膜症―急性心筋梗塞患者30例の検討―
    木下望, 梯彰弘, 片山卓志, 安隆則, 黒木昌寿, 釣巻穣, 大野隆一郎, 斎藤宗靖, 川上正舒 第56回日本臨床眼科学会プログラム講演抄録集 86 2002年10月 [査読無し][通常論文]
  • 急性心筋梗塞後発症した新奇な網膜症についての検討
    木下望, 梯彰弘, 片山卓志, 安隆則, 黒木昌寿, 釣巻穣, 大野隆一郎, 山上博子, 斎藤宗靖, 川上正舒 日眼会誌 106 (臨時増刊号) 156 2002年05月 [査読無し][通常論文]
  • Retinopathy Associated with Myocardial Infarction.
    Kinoshita N, Kakehashi A, Katayama T, Yasu T, Ohno R, Yamagami H, Tsurimaki Y, Kuroki M, Saitou M, Kawakami M Clin Exp Ophthalmol 30 (Suppl) A379 2002年 [査読有り][通常論文]
  • 糖尿病網膜症に対するSU薬の予防的作用―Acridine Orange Leukocyte Fluorographyによる解析―
    木下望, 梯彰弘, 加園恵三, 伊藤由香, 高橋雄二, 伊野田繁, 安隆則, 為本浩至, 生井一之, 黒木昌寿, 川上正舒, 金澤康徳 糖尿病合併症 15 (Supplement-1) 93 2001年09月 [査読有り][通常論文]
  • Prevention of retinal leukostasis by gliclazide in streptozotocin-induced diabetic rats
    A Kakehashi, N Kinoshita, Y Ito, Y Takahashi, T Yasu, M Kuroki, S Inoda, M Kawakami, Y Kanazawa DIABETOLOGIA 44 A288 -A288 2001年08月 [査読無し][通常論文]
  • Immunohistochemical study of Egr-1 in diabetic rat retinas.
    Y Ito, A Kakehashi, N Kinoshita, Y Takahashi, H Ueba, M Kuroki, M Kawakami INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 42 (4) S204 -S204 2001年03月 [査読無し][通常論文]
  • Immunohistochemical study of osteopontin in diabetic rat retinas.
    A Kakehashi, Y Ito, N Kinoshita, Y Takahashi, H Ueba, M Kuroki, M Kawakami INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 42 (4) S209 -S209 2001年03月 [査読無し][通常論文]

受賞

  • 2013年05月 埼玉県眼科医会 平成24年度埼玉県眼科医会賞
     
    受賞者: 木下望
  • 2002年05月 日本眼科学会 第106回日本眼科学会総会 優秀演題賞
     
    受賞者: 木下望

共同研究・競争的資金等の研究課題

担当経験のある科目

  • 眼科自治医科大学附属さいたま医療センター、公立和田山病院
  • 内科公立村岡病院
  • 総合診療科美方町国保大谷診療所

メディア報道

  • 報道 : 2019年10月12日
    執筆者 : 本人以外
    発行元・放送局 : American Academy of Ophthalmology
    番組・新聞雑誌 : News Releases
     会誌・広報誌 Study shows benefit in combining two existing treatments. SAN FRANCISCO — Combining two different treatment methods to slow the progression of myopia may deliver better results than either can achieve on their own. A new, two-year study shows that treating children with eye drops and contact lenses was 28 percent to 38 percent more effective in slowing myopia. The researchers present their results today at AAO 2019, the 123rd Annual Meeting of the American Academy of Ophthalmology.
  • オルソケラトロジー
    報道 : 2018年09月10日
    執筆者 : 本人
    発行元・放送局 : CBCラジオ
    番組・新聞雑誌 : 多田しげおの気分爽快!!~朝からP・O・N
     テレビ・ラジオ番組
  • 報道 : 2017年01月06日
    執筆者 : 本人以外
    発行元・放送局 : 毎日新聞社
    番組・新聞雑誌 : 毎日新聞
     新聞・雑誌 日本人と言えば眼鏡姿。世界からそんなふうに見られた時代もあった。今、目の良い人が周囲にどれだけいるだろうか。日本人の視力の実態は?
  • 報道 : 2015年06月05日
    執筆者 : 本人以外
    発行元・放送局 : サンケイリビング新聞社
    番組・新聞雑誌 : シティリビング東京版 2015年6月5日号
     会誌・広報誌 スマホや携帯ゲームの普及に伴って、近視の発症年齢が下がっています。

その他

  • 2014年10月 - 9999年  眼科指導医 
    日本眼科学会
  • 2005年10月 - 9999年  眼科専門医 
    日本眼科学会
  • 2014年07月 - 2019年07月  トラベクトーム認定医 
    トラベクトーム手術研究会


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