研究者総覧

西野 宏 (ニシノ ヒロシ)

  • 耳鼻咽喉科 教授
Last Updated :2021/11/23

研究者情報

学位

  • 医学博士(自治医科大学)

ホームページURL

J-Global ID

プロフィール

  • 【専門領域】頭頸部癌、頭頸部外科学

    【基礎研究】癌細胞の生物学的活性(浸潤能、転移能、幹細胞)、嗅上皮組織の再生

    【臨床研究】機能形態温存治療(上顎洞癌集学治療、外科手術)、抗癌薬同時併用化学放射線治療、分子標的薬同時併用放射線治療、導入化学療法、高齢者の癌治療

    【主な所属学会】ASCO、AAO-HNS、癌学会、癌治療学会、日本耳鼻咽喉科学会、頭頸部癌学会、頭頸部外科学会、日本鼻学会

    【その他】東京大学医科学研究所附属病院脳腫瘍外科と共同研究「進行性嗅神経芽細胞腫患者に対する増殖型遺伝子組換え単純ヘルペスウイルスG47Δを用いたウイルス療法の臨床研究、JCOG「JCOG1008局所進行頭頸部扁平上皮癌術後再発High-Risk患者に対するHigh dose CDDPを同時併用する術後補助化学放射線療法とweekly CDDOPを同時併用する術後補助化学放射線療法ランダム化第II/III相試験

研究キーワード

  • 頭頸部癌   

研究分野

  • ライフサイエンス / 耳鼻咽喉科学

経歴

  • 自治医科大学(JMU)教授

研究活動情報

論文

  • Akihiro Homma, Ryuichi Hayashi, Kazuto Matsuura, Kengo Kato, Kazuyoshi Kawabata, Nobuya Monden, Yasuhisa Hasegawa, Tetsuro Onitsuka, Yasushi Fujimoto, Shigemichi Iwae, Kenji Okami, Takashi Matsuzuka, Kunitoshi Yoshino, Ken-ichi Nibu, Takakuni Kato, Hiroshi Nishino, Takahiro Asakage, Ichiro Ota, Morimasa Kitamura, Akira Kubota, Tsutomu Ueda, Kaichiro Ikebuchi, Akihito Watanabe, Masato Fujii
    ANNALS OF SURGICAL ONCOLOGY 21 5 1706 - 1710 2014年05月 [査読有り][通常論文]
     
    The purpose of this study was to evaluate the incidence of lymph node metastasis among patients with T4 maxillary sinus squamous cell carcinoma (MS-SCC) as well as the delayed metastasis rate and the treatment outcome for untreated N0 neck in patients with T4 MS-SCC. Consecutive series of all patients (n = 128) with previously untreated T4 maxillary sinus SCC between 2006 and 2007 were obtained from 28 institutions belonging to or cooperating in the Head and Neck Cancer Study Group of the Japan Clinical Oncology Group. Of the 128 patients, 28 (21.9 %) had lymph node metastasis, and six patients (4.7 %) had distant metastasis at diagnosis. Among the 111 patients who were treated with curative intent, 98 had clinically N0 neck disease and did not receive prophylactic neck irradiation. A total of 11 patients (11.2 %) subsequently developed evidence of lymph node metastasis, of whom eight were among the 83 patients with an N0 neck and had not received elective neck treatment. There were 15 patients who received an elective neck dissection as part of the initial treatment, of whom three had pathologically positive for lymph node metastases. Of 11 patients, six patients with nonlateral retropharyngeal lymph node metastasis without primary or distant disease were successfully salvaged. This study identified the incidence of lymph node metastasis among patients with T4 MS-SCC as well as the delayed metastasis rate and the treatment outcome for untreated N0 neck in patients with T4 MS-SCC. These results will be of assistance in selecting treatment strategy for T4 MS-SCC in the future.
  • Shingo Matsuzawa, Takeharu Kanazawa, Takehiko Yamaguchi, Hiroshi Nishino, Kazumi Kawada, Keiichi Ichimura
    Head and Neck 35 10 E317 - E320 2013年10月 [査読有り][通常論文]
     
    Background: Epithelioid hemangioendotheliomas (EHEs) of the head and neck region are uncommon malignant neoplasms that exhibit various biologic behaviors characteristic of both low- and high-grade malignancy. A subgroup of EHEs identified as "high-risk" EHEs because of their size and mitotic activity is associated with an unfavorable clinical course and poor prognosis. Materials and Results: We describe the treatment of the first and, in terms of size, largest case of high-risk EHE arising from the neck. Despite wide excision, recurrence occurred 9 months after surgery, as had been expected. However, the tumor was found to express both vascular endothelial growth factor (VEGF) and VEGF receptor 2, indicating the potential of anti-VEGF therapy in the treatment of such cases. Conclusion: The finding that a high-risk EHE arising from the head and neck region is characterized by expression of VEGF and its receptor provides further support for the development of targeted molecular therapies. © 2012 Wiley Periodicals, Inc.
  • Hiroshi Nishino, Minako Takanosawa, Kazumi Kawada, Takeharu Kanazawa, Keiichi Ichimura, Satoru Takahashi, Masanori Nakazawa
    Head and Neck 35 6 772 - 778 2013年06月 [査読有り][通常論文]
     
    Background Current goals for the treatment of maxillary sinus carcinoma include the preservation of vision, eating, communication, and appearance, as well as the achievement of a cure. Methods Japanese patients (n = 121) with maxillary sinus carcinoma were analyzed retrospectively. All patients underwent multidisciplinary therapy including minimally invasive resection, 20 Gy irradiation, and intra-arterial infusion of 5-fluorouracil. Results The 5- and 10-year overall survival rates were 73% and 68%, respectively. In 97 patients with squamous cell carcinoma (SCC), the 5- and 10-year overall survival rates were 76% and 70%, respectively. All 29 patients with orbital invasion retained the orbital contents, and 21 of these patients demonstrated adequate visual acuity. There were 16 complications, including trismus (5 patients), double vision (5 patients), fistula formation (3 patients), and cataract (3 patients). Conclusion A multidisciplinary therapy, consisting of minimally invasive resection, irradiation, and regional chemotherapy, can yield good patient prognosis and quality of life after treatment. © 2012 Wiley Periodicals, Inc.
  • Takeharu Kanazawa, Noriyoshi Fukushima, Shoichiro Imayoshi, Takafumi Nagatomo, Kazumi Kawada, Hiroshi Nishino, Kiyoshi Misawa, Keiichi Ichimura
    SpringerPlus 2 1 153  2013年 [査読有り][通常論文]
     
    Recurrent respiratory papillomatosis (RRP), a chronic upper respiratory condition characterized by diffuse multiple recurring papillomas, is thought to result from human papillomavirus (HPV) type 6 or 11 infection. Although RRP is an intractable disease, malignant transformation of RRP is rare. The underlying mechanism, however, has not been elucidated. We describe the clinical course of a patient who underwent more than 130 operations for RRP associated with HPV type 6 infection and subsequently suffered spontaneous malignant transformation to squamous cell carcinoma. Immunohistochemical analysis revealed that malignant transformation might result from a genomic defect, such as p53 inactivation, leading to stimulation of uncontrolled cell proliferation by HPV type 6 for an extended period, but not directly because of HPV itself. Our results could help in the development of novel therapeutic strategies for severe RRP, although further studies are required before clinical application of molecular targeted therapies. © 2013 Kanazawa et al.
  • Takeharu Kanazawa, Noriyoshi Fukushima, Hidetaka Tanaka, Juntaro Shiba, Hiroshi Nishino, Hiroyuki Mineta, Keiichi Ichimura
    Journal of Medical Case Reports 6 431  2012年 [査読有り][通常論文]
     
    Introduction. Primary involvement of the salivary glands in small cell carcinoma is rare, and has one of the worst prognoses of salivary gland neoplasms. However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration. Multidisciplinary therapy was usually required to achieve long-term survival. Recently, a resemblance of some small cell carcinomas of the salivary gland to cutaneous Merkel cell carcinoma was suggested the latter have the potential for spontaneous regression, which is related to a favorable clinical outcome. Case presentation. We present a locoregional advanced parotid small cell carcinoma with multiple lymph node metastases in an 87-year-old Asian woman. The tumor was controlled by surgery alone, and nine-year disease-free survival was achieved without any adjunctive therapy. To the best of our knowledge, this is the longest reported follow-up of head and neck small cell carcinoma. Conclusion: We believe this to be the first case of small cell carcinoma with involvement of the salivary glands reported in the literature with a good outcome after surgery alone without any adjunctive therapy. © 2012 Kanazawa et al. licensee BioMed Central Ltd.
  • Yoshinori Hosoya, Shunji Sarukawa, Shiro Matsumoto, Toru Zuiki, Masanobu Hyodo, Koichi Abe, Hiroshi Nishino, Yasushi Sugawara, Alan T. Lefor, Yoshikazu Yasuda
    ANNALS OF THORACIC SURGERY 87 2 647 - 649 2009年02月 [査読有り][通常論文]
     
    Several options exist for reconstruction after total esophagectomy in patients with esophageal carcinoma. However, the options for a major resection after previous head and neck surgery in these patients are extremely limited. The procedure performed in 2 patients requiring esophagectomy after resection for previous head and neck malignancies is described. Both patients underwent previous chemoradiation therapy and free jejunal transfer for hypopharyngeal squamous cell carcinoma. Esophagectomy and reconstruction with a cervical gastrojejunal anastomosis combined with deltopectoral flaps were performed after the diagnosis of esophageal disease. Soft tissue defects were closed with a modified deltopectoral flap using de-epithelization. The deltopectoral flap is effective not only for cutaneous resurfacing, but also to promote delayed wound healing after radiation therapy. This report demonstrates a useful multidisciplinary approach for resection and reconstruction in patients after a previous free jejunal transfer.
  • Minako Takanosawa, Hiroshi Nishino, Yasushi Ohta, Keiichi Ichimura
    ACTA OTO-LARYNGOLOGICA 129 9 1002 - 1009 2009年 [査読有り][通常論文]
     
    Conclusion: Glucocorticoid (GC) administration enhanced apoptotic changes in mature olfactory receptor neurons (ORNs). GC administration may enhance regeneration of olfactory epithelium (OE). Objectives: The mechanism underlying olfactory epithelial cells turnover involves apoptosis replaced by new ORNs. On regeneration of OE, we evaluated the apoptotic changes in OE. Our aim was to corroborate the enhancement of apoptosis of ORNs induced by GCs that are generally administered locally or systemically to patients with olfactory dysfunction. Materials and methods: For the in vitro study, we established cultured murine ORNs. Triamcinolone acetonide was added to culture supernatants. ORNs were then cultured for another 2 weeks. In the in vivo study, triamcinolone acetonide was administered to mice 5 or 10 times. The mice were dissected 3 days after the final injection, and the olfactory regions were removed and embedded in paraffin. All samples were examined by immunohistochemical staining and the TdT-mediated dUTP-biotin nick-end labeling (TUNEL) method. Results: Glucocorticoid receptor (GR) expression of cultured murine ORNs was observed among ORNs at the mature stage. Expression of GRs by murine OE was localized on mature ORNs and supporting cells. Administration of GC to both cultured ORNs and mice resulted in proportions of apoptotic cells that were significantly higher than those in the control groups.
  • Takeharu Kanazawa, Hiroshi Nishino, Masahiro Hasegawa, Yasushi Ohta, Yukiko Iino, Keiichi Ichimura, Yutaka Noda
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 264 7 815 - 821 2007年07月 [査読有り][通常論文]
     
    Interleukin-6 (IL-6) is a multifunctional regulator of immune response and hematopoiesis. Recently, it has been reported that expression of IL-6 is correlated with prognosis in various cancer patients. In this study, we investigated whether the proliferation and invasion potential of head and neck squamous cell carcinomas (HNSCCs) were influenced by IL-6. All HNSCC cell lines, HEp-2, HSC-2, HSC-4, and SAS, were tested by reverse transcription-polymerase chain reaction (RT-PCR) and expressed the IL-6 receptor (IL-6R), and glycoprotein 130, which is responsible for signal transduction. HEp-2, HSC-2, and HSC-4 also produced IL-6. IL-6 inhibited the proliferation of HSC-2 and SAS, but the invasion potential of all the cell lines increased. Moreover, IL-6 down-regulated soluble IL-6R expression. Anti-IL-6R antibody abrogated the inhibited proliferation and increased invasion induced by IL-6. IL-6 stimulation also induced the extracellular regulated protein kinase 1/2 activation and increased vascular endothelial growth factor release. These results suggest that IL-6 can directly influence cell proliferation and the invasion potential as the first step of tumor metastasis.
  • Kazuhiro Ishikawa, Hideshi Ishii, Yoshiki Murakumo, Koshi Mimori, Masahiko Kobayashi, Ken-ichi Yamamoto, Masaki Mori, Hiroshi Nishino, Yusuke Furukawa, Keiichi Ichimura
    BMC MOLECULAR BIOLOGY 8 37  2007年05月 [査読有り][通常論文]
     
    Background: Previous studies suggest that human RAD9 ( hRad9), encoding a DNA damage checkpoint molecule, which is frequently amplified in epithelial tumor cells of breast, lung, head and neck cancer, participates in regulation of the tumor suppressor p53- dependent transactivation of pro- survival P21(WAF1). This study examined the exact mechanism of the hRad9 function, especially through the phosphorylation of the C- terminus, in the transcription regulation of P2(1WAF1). Results: The transfection of phosphorylation- defective hRAD9 mutants of C- terminus resulted in reduction of the p53- dependent P21(WAF1) transactivation; the knockdown of total hRad9 elicited an increased P21(WAF1) mRNA expression. Immunoprecipitation and a ChIP assay showed that hRad9 and p53 formed a complex and both were associated with two p53- consensus DNA- binding sequences in the 5' region of P21(WAF1) gene. The association was reduced in the experiment of phosphorylation- defective hRAD9 mutants. Conclusion: The present study indicates the direct involvement of hRad9 in the p53- dependent P21(WAF1) transcriptional mechanism, presumably via the phosphorylation sites, and alterations of the hRad9 pathway might therefore contribute to the perturbation of checkpoint activation in cancer cells.
  • Koichi Abe, Hiroshi Nishino, Nobuko Makino, Kazuhiro Ishikawa, Kotaro Ishikawa, Keiko Imai, Keiichi Ichimura
    Journal of Otolaryngology of Japan 110 1 13 - 19 2007年 [査読有り][通常論文]
     
    Arytenoid cartilage dislocation is a known complication of tracheal intubation and is also a type of laryngeal injury. Although spontaneous recovery has been reported, most patients require reduction via pharyngoscopy under general or neuroleptic anesthesia, and some must be treated by open reduction such as laryngoplasty. We report 8 cases of arytenoid cartilage dislocation between August 2003 and August 2004. Excluding 3 patients who recovered spontaneously, we conducted reduction under local anesthesia as an ambulatory procedure in the other 5 with anterior dislocation, i.e., 2 men and 3 women aged 53 to 75 years old. Of these 5, dislocation occurred after tracheal intubation in 4, and in 1 after wearing a laryngeal mask. The outcome was favorable in all 5. Surgery was conducteded after a fiberscope was inserted nasally and a urethral balloon catheter was inserted via the other nasal cavity under topical anesthesia with 4% lidocaine for both nasal cavities and the larynx. While monitoring the larynx, we expanded the balloon and pulled it away from the glottis. The expanded balloon was then placed at the arytenoid region for a few seconds. This procedure was repeated several times to achieve reduction. Three patients recovered well within 1 to 2 weeks of the first reduction, while 2 requierd a second reduction because of insufficient improvement after the first. These two both showed improved vocal cord movement and recovery from hoarseness within 1 to 2 weeks after the second reduction. We conducted 7 reductions without complications in any patient. Our approach is usable in the ambulatory setting, and is simple, minimally invasive, and effective. We consider it to be useful treatment for anterior arytenoid cartilage dislocation.
  • H Nishino, K Ichimura, H Tanaka, K Ishikawa, K Abe, Y Fujisawa, T Shinozaki
    LARYNGOSCOPE 113 6 1064 - 1069 2003年06月 [査読有り][通常論文]
     
    Objective: The purpose of the study was to examine the oncological. and functional outcomes of multimodality therapy for patients with advanced malignant maxillary sinus tumors that invaded the orbit. Study Design: Retrospective study. Methods: The medical records of 26 patients with orbital invasion were retrospectively analyzed. The patient group consisted of 16 men and 10 women, with a median age of 58 years. The mean follow-up period was 73 months. The most common disease was squamous cell carcinoma. Seven patients had nodal disease. All patients underwent simultaneous combined therapy consisting of conservative surgery through a sublabial incision, radiotherapy, and regional chemotherapy. Patients with nodal disease were treated with either irradiation- or selective neck dissection. Results: The 5- and 10-year overall survival rates were 68% and 51%, respectively. The 5- and 10-year local control rates were 66% and 51%, respectively. Overall survival rates and local control rates were significantly worse in patients with disease other than squamous cell carcinoma. Local control rates were significantly worse in patients with orbital apex disease than in patients without orbital apex disease. All 26 patients, despite orbital involvement, retained their orbital contents. Nineteen of these patients demonstrated adequate ocular function. Conclusions: Combined therapy with conservative surgery, radiotherapy, and regional chemotherapy is an effective method for local control and preservation of ocular function. However, performing orbital conservation procedure in patients with disease other than squamous cell carcinoma and with orbital apex disease must be considered carefully.
  • Nishino H, Shinozaki T, Ishikawa K, Tanaka H, Ichimura K
    Gan to kagaku ryoho. Cancer & chemotherapy 29 2019 - 2023 11 2002年11月 [査読有り][通常論文]

MISC

共同研究・競争的資金等の研究課題

  • 頭頸部外科、癌細胞浸潤・転移、癌化学療法、血管新生
    委託研究
    研究期間 : 2000年 
    頭頸部外科、癌細胞浸潤・転移、癌化学療法、血管新生


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