研究者総覧

細野 茂春 (ホソノ シゲハル)

  • 総合医学第1講座 教授
Last Updated :2021/09/22

研究者情報

学位

  • 博士(医学)(日本大学)

ホームページURL

科研費研究者番号

  • 50339339

J-Global ID

研究キーワード

  • 輸血   終末呼気二酸化炭素分圧   新生児蘇生   胎盤血輸血   臍帯ミルキング   慢性肺疾患   新生児蘇生   新生児の輸血   新生児の貧血(未熟児貧血)   胎盤血輸血   

研究分野

  • ライフサイエンス / 胎児医学、小児成育学

経歴

  • 2018年08月 - 現在  自治医科大学附属さいたま医療センター周産期科新生児部門教授
  • 2017年04月 - 2018年07月  日本大学医学部小児科学系小児科学分野診療教授
  • 2009年06月 - 2018年07月  日本大学医学部小児科学系小児科学分野准教授
  • 2007年05月 - 2009年05月  日本大学医学部小児科助教
  • 2001年04月 - 2007年03月  日本大学医学部小児科助手
  • 1993年04月 - 2001年03月  埼玉県立小児医療センター 未熟児新生児科
  • 1992年04月 - 1993年03月  日本大学板橋病院 小児科助手(無給)
  • 1989年04月 - 1992年03月  東京都立大塚病院 小児科

学歴

  •         - 1989年   日本大学   大学院 医学研究科   小児科学
  •         - 1985年   日本大学   医学部医学科

所属学協会

  • Federation of Asia and Oceania Perinatal Societies   日本周産期・新生児医学会   日本産婦人科・新生児血液学会   日本輸血細胞治療学会   日本小児科学会   日本未熟児新生児学会   日本小児保健学会   フォローアップ研究会   慢性肺疾患研究会   World Association of Perinatal Medicine   

研究活動情報

論文

  • Kennosuke Tsuda, Sachiko Iwata, Takeo Mukai, Jun Shibasaki, Akihito Takeuchi, Tomoaki Ioroi, Hiroyuki Sano, Nanae Yutaka, Akihito Takahashi, Toshiki Takenouchi, Satoshi Osaga, Takuya Tokuhisa, Sachio Takashima, Hisanori Sobajima, Masanori Tamura, Shigeharu Hosono, Makoto Nabetani, Osuke Iwata
    Therapeutic hypothermia and temperature management 9 1 76 - 85 2019年03月 [査読有り][通常論文]
     
    Therapeutic hypothermia following neonatal encephalopathy is neuroprotective. However, approximately one in two cooled infants still die or develop permanent neurological impairments. Further understanding of variables associated with the effectiveness of cooling is important to improve the therapeutic regimen. To identify clinical factors associated with short-term outcomes of cooled infants, clinical data of 509 cooled infants registered to the Baby Cooling Registry of Japan between 2012 and 2014 were evaluated. Independent variables of death during the initial hospitalization and survival discharge from the cooling hospital at ≤28 days of life were assessed. Death was associated with higher Thompson scores at admission (p < 0.001); higher heart rates after 3-72 hours of cooling (p < 0.001); and higher body temperature after 24 hours of cooling (p = 0.002). Survival discharge was associated with higher 10 minutes Apgar scores (p < 0.001); higher blood pH and base excess (both p < 0.001); lower Thompson scores (at admission and after 24 hours of cooling; both p < 0.001); lower heart rates at initiating cooling (p = 0.003) and after 24 hours of cooling (p < 0.001) and lower average values after 3-72 hours of cooling (p < 0.001); higher body temperature at admission (p < 0.001); and lower body temperature after 24 hours and lower mean values after 3-72 hours of cooling (both p < 0.001). Survival discharge was best explained by higher blood pH (p < 0.05), higher body temperature at admission (p < 0.01), and lower body temperature and heart rate after 24 hours of cooling (p < 0.01 and <0.001, respectively). Lower heart rate, higher body temperature at admission, and lower body temperature during cooling were associated with favorable short-term outcomes.
  • Katheria A, Hosono S, El-Naggar W
    Seminars in fetal & neonatal medicine 2018年07月 [査読有り][通常論文]
  • Midori Yoda, Shigeharu Hosono, Nobuhiko Nagano, Kayo Yoshikawa, Shori Takahashi
    PEDIATRICS INTERNATIONAL 59 10 1093 - 1094 2017年10月 [査読有り][通常論文]
  • Hitomi Odajima, Shigeharu Hosono, Kazunori Kayama, Kayo Yoshikawa, Shori Takahashi
    PEDIATRICS INTERNATIONAL 59 10 1107 - 1108 2017年10月 [査読有り][通常論文]
  • Toshihiko Nakamura, Hideomi Asanuma, Satoshi Kusuda, Ken Imai, Shigeharu Hosono, Ryota Kato, Satoshi Suzuki, Kyoko Yokoi, Minoru Kokubo, Shingo Yamada, Takashi Kamohara
    PEDIATRICS INTERNATIONAL 59 10 1074 - 1079 2017年10月 [査読有り][通常論文]
     
    BackgroundWe measured changes in the blood level of high-mobility group box-1 (HMGB-1) at 24 h intervals in neonates treated with brain/body hypothermia (body hypothermia therapy: BHT) for hypoxic-ischemic encephalopathy (HIE), to evaluate the usefulness of HMGB-1 level for determining outcomes. MethodsWe studied 15 neonates with HIE who underwent BHT (BHT (+) group) and six neonates with HIE who did not (BHT (-) group). We recorded HMGB-1 changes at 24 h intervals, creatinine phosphokinase, and the resistance index of the anterior cerebral artery. Magnetic resonance imaging (MRI) was used to determine short-term outcome. ResultBaseline HMGB-1 was significantly higher in the BHT (+) group than in the BHT (-) group. Thereafter, HMGB-1 in the BHT (+) group significantly decreased at 24 h intervals, reaching the reference range by 2 days of age. In the BHT (+) group, when patients were classified into clinically significant neurological disorder due to HIE (+) and (-) according to MRI, the neurological disorder (+) group had higher mean HMGB-1. ConclusionsIn HIE, HMGB-1 differs according to the presence of BHT, suggesting that HMGB-1 measurement soon after birth might be useful for determining BHT necessity and short-term outcome.
  • Yosuke Taguchi, Shigeharu Hosono, Kazunori Kayama, Ryota Kato, Kotaro Hine, Nobuhiko Nagano, Kayo Yoshikawa, Shigeru Takahashi, Shori Takahashi
    PEDIATRICS INTERNATIONAL 59 10 1064 - 1068 2017年10月 [査読有り][通常論文]
     
    BackgroundDuring neonatal resuscitation, careful oxygenation is needed. Pulse oximetry is recommended to evaluate the need for oxygenation, but it is not clear whether peripheral perfusion is adequate for the evaluation of arterial oxygen saturation (SpO(2)). Additionally, there has been no study on the changes in SpO(2) immediately after birth in Japan, despite the indispensable need for definitive oxygenation criteria. MethodsA prospective observational study was performed in neonates at gestational age 35-41weeks. An SpO(2) measurement probe was attached to the neonates immediately after birth at the right palm or wrist, and the perfusion index (PI), pulse rate, and SpO(2) were measured until 10min after birth. ResultsSixty neonates were examined. Stable PI was obtained soon after birth, preceding SpO(2) measurement. The median PI (%) was constant at approximately 1.3, and the median SpO(2) at 2-10min was 70%, 81%, 82%, 87%, 89%, 92%, 92%, 94%, and 95%, respectively. The current target value for SpO(2) in the Neonatal Cardiopulmonary Resuscitation (NCPR) guideline in Japan is approximately the 25th percentile. ConclusionPI is stable and sufficient in the early postnatal period, meaning that peripheral perfusion is adequate for the measurement of SpO(2). The current target SpO(2) used in the NCPR guidelines is at approximately the 25th percentile and is thought to be sufficient for meeting oxygenation criteria.
  • Kazumasa Fuwa, Shigeharu Hosono, Nobuhiko Nagano, Shori Takahashi, Motohiro Nakashima
    PEDIATRICS INTERNATIONAL 59 3 360 - 361 2017年03月 [査読有り][通常論文]
     
    Sildenafil (SIL) is used as a rescue treatment for severe bronchopulmonary dysplasia and pulmonary arterial hypertension. SIL inhibits phosphodiesterase 6 (PDE6) as well as PDE5. Therefore, it is controversial as to whether SIL increases the risk of retinopathy of prematurity (ROP).
  • Takahiro Sugiura, Rei Urushibata, Kenji Komatsu, Tsutomu Shioda, Tatsuki Ota, Megumi Sato, Yumiko Okubo, Tetsuya Fukuoka, Shigeharu Hosono, Masanori Tamura
    PEDIATRICS INTERNATIONAL 59 2 154 - 158 2017年02月 [査読有り][通常論文]
     
    BackgroundGuidelines recommend avoiding excessive oxygen during neonatal resuscitation. Recent studies have suggested that oxygen titration can be achieved using a self-inflating bag, but data on the effectiveness of resuscitators used in neonatal ventilation are scarce, The aim of this study was therefore to determine the amount of oxygen delivered using several brands of neonatal self-inflating resuscitation bags without reservoirs under different conditions with regard to oxygen flow rate, ventilation rate (VR), peak inspiratory pressure (PIP) range, and test lung compliance. MethodsOxygen concentration was measured under a variety of conditions. Combinations of oxygen flow rate (10, 5.0, 3.0 and 1.0 L/min), VR (40, 60 inflations/min), PIP range (20-25 cmH(2)O, 35-40 cmH(2)O), and test lung compliance (0.6, 1.0, 3.0, and 5.0 mL/cmH(2)O) were examined using six kinds of self-inflating bag. ResultsDelivered oxygen concentration varied widely (30.1-96.7%) and had a significant positive correlation with gas flow rate in all of the bags. Delivered oxygen concentration was also negatively correlated with PIP in all of the bags and with VR in some of them. Test lung compliance did not affect delivered oxygen concentration. ConclusionThe use of neonatal resuscitation self-inflating bags without reservoirs resulted in different delivered oxygen concentrations depending on gas flow rate, VR, PIP, and manufacturer, but not on lung compliance. This suggests that targeted oxygen concentrations could be delivered, even in lungs with decreased compliance, during resuscitation.
  • Therapeutic hypothermia for neonatal encephalopathy: a report from the first 3 years of the Baby Cooling Registry of Japan
    Tsuda Kennosuke, Mukai Takeo, Iwata Sachiko, Shibasaki Jun, Tokuhisa Takuya, Ioroi Tomoaki, Sano Hiroyuki, Yutaka Nanae, Takahashi Akihito, Takeuchi Akihito, Takenouchi Toshihiko, Araki Yuko, Sobajima Hisanori, Tamura Masanori, Hosono Shigheharu, Nabetani Makoto, Iwata Osuke, Baby Cooling, Registry of Japan Collaboration Team
    Scientific Reports. 7 39508  2017年 [査読有り][通常論文]
  • Nobuhiko Nagano, Tomoo Okada, Kazunori Kayama, Shigeharu Hosono, Yohei Kitamura, Shigeru Takahashi
    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 115 8 - 11 2016年12月 [査読有り][通常論文]
     
    Term neonates have high delta-6 desaturase (D6D) activity, which is important for regulating polyunsaturated fatty acid's (PUFA) nutritional status. The aim was to investigate D6D activity in preterm infants and its postnatal changes. Forty-three appropriate-for-gestational-age infants were included. PUFA in red blood cells was analyzed at birth and at one, six, and 12 months of age. D6D activity was estimated by 20:3n-6/18:2n-6 ratio. At birth, preterm infants had D6D activity as high as that of term infants; D6D activity declined to about one-third at one month, then further decreased to about one-sixth at six months and remained stable until 12 months. The postnatal change in arachidonic acid exhibited a similar pattern to that of D6D activity; however, docosahexaenoic acid showed a transient decrease at one month and recovered to the cord blood level at six months. D6D may regulate PUFA profile in preterm infants, especially during the early postnatal period.
  • Nobuhiko Nagano, Kayo Yoshikawa, Shigeharu Hosono, Shori Takahashi, Tomohiro Nakayama
    PEDIATRICS INTERNATIONAL 58 12 1371 - 1372 2016年12月 [査読有り][通常論文]
  • Ju Lee Oei, Alpana Ghadge, Elisabeth Coates, Ian M. Wright, Ola D. Saugstad, Maximo Vento, Giuseppe Buonocore, Tatsuo Nagashima, Keiji Suzuki, Shiguhero Hosono, Peter G. Davis, Paul Craven, Lisa Askie, Jennifer Dawson, Shalabh Garg, Anthony Keech, Yacov Rabi, John Smyth, Sunil Sinha, Ben Stenson, Kei Lui, Carol Lu Hunter, William Tarnow Mordi
    ACTA PAEDIATRICA 105 9 1061 - 1066 2016年09月 [査読有り][通常論文]
     
    AimThis study determined current international clinical practice and opinions regarding initial fractional inspired oxygen (FiO(2)) and pulse oximetry (SpO(2)) targets for delivery room resuscitation of preterm infants of less than 29 weeks of gestation. MethodsAn online survey was disseminated to neonatal clinicians via established professional clinical networks using a web-based survey programme between March 9 and June 30, 2015. ResultsOf the 630 responses from 25 countries, 60% were from neonatologists. The majority (77%) would target SpO(2) between the 10th to 50th percentiles values for full-term infants. The median starting FiO(2) was 0.3, with Japan using the highest (0.4) and the UK using the lowest (0.21). New Zealand targeted the highest SpO(2) percentiles (median 50%). Most respondents agreed or did not disagree that a trial was required that compared the higher FiO(2) of 0.6 (83%), targeting the 50th SpO(2) percentile (60%), and the lower FiO(2) of 0.21 (80%), targeting the 10th SpO(2) percentile (78%). Most (65%) would join this trial. Many considered that evidence was lacking and further research was needed. ConclusionClinicians currently favour lower SpO(2) targets for preterm resuscitation, despite acknowledging the lack of evidence for benefit or harm, and 65% would join a clinical trial.
  • Hine K, Hosono S, Kawabata K, Miyabayashi H, Kanno K, Shimizu M, Takahashi S
    Pediatr Int 59 27 - 29 2016年 [査読有り][通常論文]
  • Kazunori Kayama, Tomoo Okada, Kazumasa Fuwa, Nobuhiko Nagano, Shigeharu Hosono, Shigeru Takahashi, Shori Takahashi
    JOURNAL OF CLINICAL LIPIDOLOGY 9 5 647 - 651 2015年10月 [査読有り][通常論文]
     
    BACKGROUND: Fetal organs require much lipid for growth, but the cord blood had low TG concentrations, compared to adult serum. We investigated the association between the concentration of apolipoprotein A-V (apoA-V) and lipid profile in cord blood and neonatal serum. OBJECTIVE: ApoA-V was identified as an important determinant of plasma triglyceride concentrations. We sought to determine the association between serum apoA-V concentrations and lipoprotein profile in preterm infants and its early postnatal change. METHODS: Sixty-three neonates (35 males and 28 females; 15 term and 48 preterm) were included. Serum lipoprotein profile and apoA-V concentrations were determined at birth and 1 month. RESULTS: Cord blood apoA-V concentrations in appropriate-for-gestational age infants were extremely low (13.1 +/- 3.4 ng/mL in term infants, 4.4 +/- 0.9 ng/mL in preterm infants) compared with adult values, and those of small-for-gestational age infants were further low (6.4 +/- 4.2 ng/mL, 2.2 +/- 1.3 ng/mL, respectively). During the first month, serum apoA-V concentration markedly increased, and the concentration of preterm appropriate-for-gestational age infants caught up, whereas that of preterm small-for-gestational age infants did not. At birth, apoA-V concentration positively correlated with gestational age (r = 0.354, P = .0069) but not with birth weight Z-score. ApoA-V concentration had a positive association with very low density lipoprotein triglyceride concentrations (r = 0.646, P < .0001), and the relationships still remained at 1 month (r = 0.283, P = .0348). CONCLUSIONS: ApoA-V in neonates was unique in its serum concentration and in the association with lipoprotein profile. (C) 2015 National Lipid Association. All rights reserved.
  • Hidehiko Maruyama, Naohiro Yonemoto, Yumi Kono, Satoshi Kusuda, Masanori Fujimura
    PLOS ONE 10 9 2015年09月 [査読無し][通常論文]
     
    IntroductionThis study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs).MethodsSubjects were infants who weighed 501-1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003-2007). Patel's exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI).ResultsIn the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.41-1.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95% CI, 1.60-3.62) and 1.81 (95% CI, 1.18-2.75), respectively, relative to the reference WGV score of 10. WGV scores >= 8 did not predict death or NDI.ConclusionsWGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs.
  • Kunihito Matsumoto, Souksavanh Vongsa, Ichiro Nakajima, Ken-ichiro Ejima, Kiyomi Kohinata, Toshihiro Suzuki, Shigeharu Hosono, Hirofumi Aboshi, Fumiyuki Kuwata, Kichibee Otsuka
    JOURNAL OF ORAL SCIENCE 57 3 235 - 239 2015年09月 [査読有り][通常論文]
     
    As part of quality assessment of a teleradiology program we evaluated the validity of patient information received, the quality of panoramic radiography imaging in Laos, and the ability of a Laotian radiologist to detect temporomandibular joint abnormalities. The amount of patient information gathered from 2,021 scans of panoramic radiographs was evaluated by triage before image diagnosis. Among the radiographs from 2,021 patients, primary triage indicated that there was insufficient information for 794 (39.3%) patients. Secondary triage to assess imaging failure included 1,227 radiographs, four of which were excluded from imaging diagnosis because of unacceptable image flaws. In total, 2,446 joints from 1,223 radiographs were evaluated for temporomandibular joint abnormalities in order to compare the image interpretation abilities of Laotian and Japanese radiologists. The kappa coefficient was 0.836 (P < 0.01) for the agreement between the two observers in detecting temporomandibular joint abnormalities on radiographs. We conclude that additional efforts are needed in order to overcome the challenges of maintaining quality in imaging techniques and diagnoses in Laos.
  • Ursula Guillen, Elliott M. Weiss, David Munson, Pierre Maton, Ann Jefferies, Mikael Norman, Gunnar Naulaers, Joana Mendes, Lincoln Justo da Silva, Petr Zoban, Thor W. R. Hansen, Mikko Hallman, Maria Delivoria-Papadopoulos, Shigeharu Hosono, Susan G. Albersheim, Constance Williams, Elaine Boyle, Kei Lui, Brian Darlow, Haresh Kirpalani
    PEDIATRICS 136 2 343 - 350 2015年08月 [査読有り][通常論文]
     
    BACKGROUND AND OBJECTIVES: Available data on survival rates and outcomes of extremely low gestational age (GA) infants (22-25 weeks' gestation) display wide variation by country. Whether similar variation is found in statements by national professional bodies is unknown. The objectives were to perform a systematic review of management from scientific and professional organizations for delivery room care of extremely low GA infants. METHODS: We searched Embase, PubMed, and Google Scholar for management guidelines on perinatal care. Countries were included if rated by the United Nations Development Programme's Human Development Index as "very highly developed." The primary outcome was rating of recommendations from "comfort care" to "active care." Secondary outcomes were specifying country-specific survival and considering potential for 3 biases: limitations of GA assessment; bias from different definitions of stillbirths and live births; and bias from the use of different denominators to calculate survival. RESULTS: Of 47 highly developed countries, 34 guidelines from 23 countries and 4 international groups were identified. Of these, 3 did not state management recommendations. Of the remaining 31 guidelines, 21 (68%) supported comfort care at 22 weeks' gestation, and 20 (65%) supported active care at 25 weeks' gestation. Between 23 and 24 weeks' gestation, much greater variation was seen. Seventeen guidelines cited national survival rates. Few guidelines discussed potential biases: limitations in GA (n = 17); definition bias (n = 3); and denominator bias (n = 7). CONCLUSIONS: Although there is a wide variation in recommendations (especially between 23 and 24 weeks' GA), there is general agreement for comfort care at 22 weeks' GA and active care at 25 weeks' GA.
  • S. Hosono, H. Mugishima, S. Takahashi, N. Masaoka, T. Yamamoto, M. Tamura
    JOURNAL OF PERINATOLOGY 35 8 590 - 594 2015年08月 [査読有り][通常論文]
     
    OBJECTIVE: To compare two strategies to potentiate the effects of placental transfusion in infants born at <29 weeks of gestation. STUDY DESIGN: Twenty infants who received one-time umbilical cord milking after umbilical cord cutting were compared with 20 infants from a previous study group who received multiple-time umbilical cord milking. The primary outcome measurements were the probability of not needing a red blood cell (RBC) transfusion during the hospital stay and the total number of RBC transfusions within 21 days after birth. RESULT: There was no significant difference in the probability of not needing a transfusion during the hospital stay (P = 0.75) and the mean number of RBC transfusions given within the first 21 days of life (1.1 +/- 1.8 for the one-time umbilical cord-milking group vs 0.7 +/- 1.2 for the multiple-time umbilical cord-milking group, P = 0.48). CONCLUSION: One-time umbilical cord milking after umbilical cord cutting had similar beneficial effects to multiple-time umbilical cord milking before umbilical cord cutting in very premature infants.
  • Ichiro Morioka, Hajime Nakamura, Tsubasa Koda, Tomoyuki Yokota, Hitoshi Okada, Yoshinori Katayama, Tetsuya Kunikata, Masatoshi Kondo, Makoto Nakamura, Shigeharu Hosono, Saneyuki Yasuda, Naoki Yokoyama, Hiroshi Wada, Susumu Itoh, Masahisa Funato, Yoshitada Yamauchi, Yong Kye Lee, Masahiko Yonetani
    PEDIATRICS INTERNATIONAL 57 3 494 - 497 2015年06月 [査読有り][通常論文]
     
    Clinical kernicterus in preterm infants has recently been reported in Japan, diagnosed on the basis of clinical findings during the neonatal and infancy periods. We investigated the incidence of clinical kernicterus in preterm infants <30weeks gestational age (GA) based on a nationwide survey conducted in 233 certified educational facilities for neonatologists. The numbers of infants admitted and infants who died within 14days after birth during 2011, and the number of infants who subsequently developed clinical kernicterus, were recorded. A total of 2720 infants were analyzed, representing 59% (2720/4623) of all preterm live births <30weeks GA in Japan in 2011. Of these, 159 (5.8%) died within 14days after birth, similar to the national rate. Five infants developed clinical kernicterus in infancy (5/2720, 0.18%). The current incidence of clinical kernicterus in Japan is therefore estimated at 1.8 per 1000 live births <30weeks GA.
  • Shigeharu Hosono, Masanori Tamura, Tetsuya Kunikata, Masaki Wada, Isao Kusakawa, Satoshi Ibara
    PEDIATRICS INTERNATIONAL 57 2 258 - 262 2015年04月 [査読有り][通常論文]
     
    BackgroundThe aim of this study was to determine the current neonatal resuscitation practices for term infants in Japan, immediately before the 2010 publication of the international neonatal resuscitation consensus. MethodsIn January 2010, a 26-question survey was mailed to neonatal department directors. ResultsA total of 287 neonatal departments were identified. Four surveys were returned as undeliverable. A total of 191 surveys were returned completed, but four departments had no labor and delivery rooms (66.6% response rate, 65.2% survey available response rate). Flow-inflating bags were most commonly used (63.2%), followed by self-inflating bags (35.8%), and T-piece resuscitators (1.0%). Among the participants, 42.1% used oxygen blenders, 56.2% used pure oxygen for initial resuscitation, and 79.5% used a pulse oximeter to change the fraction of inspired oxygen. Among the participants, 45.3% used carbon dioxide detectors to confirm intubation, 42.5% routinely used the detectors, and 55.2% used them when confirming a difficult intubation. In addition, 42.5% of the participants used continuous positive airway pressure to treat breathing problems, most commonly with flow-inflating bags (93.2%). ConclusionsThe equipment and techniques used in Japanese perinatal center delivery room resuscitation practices are highly varied. Further research is required to determine which devices and techniques are appropriate for this important and common intervention.
  • Shigeharu Hosono, Kotaro Hine, Nobuhiko Nagano, Yosuke Taguchi, Kayo Yoshikawa, Tomoo Okada, Hideo Mugishima, Shigeru Takahashi, Shori Takahashi
    PEDIATRICS INTERNATIONAL 57 1 68 - 71 2015年02月 [査読有り][通常論文]
     
    BackgroundThe aim of this study was to investigate residual blood volume in the umbilical cord of extremely premature infants. MethodsTwenty extremely premature infants were held at or below the placenta while the umbilical cord was clamped and cut at approximately 2-3cm from the umbilicus within 30s after birth. The umbilical cord was then clamped near the placenta to obtain a length of approximately 30cm and cut. The residual blood volume in the segment of cord was drained and measured in milliliters. ResultsMean birthweight was 846 172g (range, 587-1180g). The average length of the clamped segment of umbilical cord was 29.8 +/- 1.5cm (range, 27-32cm). Total residual blood volume and residual blood volume per cm were 15.5 +/- 6.7mL (range, 6-25mL) and 0.5 +/- 0.2mL/cm (range, 0.2-0.8mL/cm), respectively. The residual cord blood volume per kilogram of infant weight per 30cm was 17.7 +/- 5.5mL/kg/30cm (range, 8.9-29.0mL/kg/30cm). ConclusionInfants could receive approximately 18mL/kg of whole blood by one-time milking of 30cm umbilical cord. With an average hematocrit of 40%, this volume is equivalent to approximately 13mL of packed red blood cells (hematocrit 55%).
  • Kazumasa Fuwa, Shigeharu Hosono, Nobuhiko Nagano, Shun Munakata, Ritsuko Fukamachi, Tomoo Okada, Shigeru Takahashi, Shori Takahashi, Naoyuki Sato, Tomohiro Nakayama
    PEDIATRICS INTERNATIONAL 57 1 E11 - E13 2015年02月 [査読有り][通常論文]
     
    Congenital chloride diarrhea (CCD) beginning in utero is a rare autosomal recessive inherited disorder characterized by impairment of Cl-/HCO3- exchange in an otherwise normal distal ileum and colon. Life-long secretory diarrhea is caused by mutations in solute carrier family 26, member 3, (SLC26A3), which disrupt epithelial Cl-/HCO3- transport in the ileum and colon. Although 55 mutations in SLC26A3 have been identified throughout the world, few Japanese cases have been confirmed on genetic analysis. We report the successful treatment of a Japanese neonate with CCD caused by SLC26A3 mutation.
  • Tomoo Okada, Shigeru Takahashi, Nobuhiko Nagano, Kayo Yoshikawa, Yukihiro Usukura, Shigeharu Hosono
    PEDIATRIC RESEARCH 77 1 136 - 142 2015年01月 [査読有り][招待有り]
     
    The concept of the developmental origins of health and disease is based on studies by Barker et al. They proposed a hypothesis that undernutrition in utero permanently changes the body's structure, function, and metabolism in ways that lead to atherosclerosis and insulin resistance in later life. In addition, profound effects on the extent of body fatness and insulin sensitivity are demonstrated, if there is a "mismatch" between prenatal and postnatal environments. In previous studies, undernutrition in utero has been evaluated simply by birth weight itself or birth weight for gestational age, and the degree of mismatch has been estimated by postnatal rapid weight gain. Recently, we investigated subcutaneous fat accumulation in small-for-gestational-age infants and found that a rapid catch-up in skinfold thickness developed prior to the body weight catch-up. Furthermore, insulin-like growth factor-I and lipoprotein lipase mass concentrations also demonstrate rapid increase during the neonatal period with fat accumulation. Investigating the precise mechanisms of developmental origins of health and disease including mediating metabolic and hormonal factors may provide a new approach to prevent atherosclerosis and insulin resistance. Better management of undernutrition during gestation and neonatal growth during the early postnatal period is an important theme for future health.
  • Sarvin Ghavam, Dushyant Batra, Judith Mercer, Amir Kugelman, Shigeharu Hosono, William Oh, Heike Rabe, Haresh Kirpalani
    TRANSFUSION 54 4 1192 - 1198 2014年04月 [査読無し][通常論文]
     
    BackgroundRisks and benefits of increasing placental transfusion in extremely preterm infants (extremely low birthweight [ELBW], <1000g) are ill defined. We performed a meta-analysis to compare long- and short-term outcomes of ELBW infants in trials of enhanced placental transfusion regimens. Study Design and MethodsWe conducted a meta-analysis of randomized controlled trials (RCTs) of delayed umbilical cord clamping or umbilical cord milking in compliance with PRISMA and Cochrane Collaborative guidelines for systematic reviews. We searched multiple databases for medical literature up to December 2012. Inclusion criteria were preterm infants less than 30 weeks and less than 1000g birthweight, randomly assigned to enhanced placental transfusion (either delayed cord clamping or cord milking) versus immediate cord clamping. The primary outcome was standardized neurodevelopmental outcome at 18 to 24 months corrected age using a standardized scale. Several short-term outcomes were also evaluated as secondary variables. ResultsWe found 19 studies of which 10 studies could be included (n=199). Three reported neurodevelopmental outcomes, none of which showed significant rates of disability. Two reported these at 18 to 24 months (n=42) but used different scales preventing pooling. Short-term benefits of enhanced placental strategies included better blood pressure and hemoglobin on admission, along with reduced blood transfusions, a trend to reduced intraventricular hemorrhage, and episodes of late-onset sepsis. ConclusionsStrategies to enhance placental transfusion may improve short-term outcomes of ELBW infants. However, paucity of data on neurodevelopmental outcomes and safety concerns tempers enthusiasm for these interventions. Appropriately designed RCTs to assess short-term and long-term outcomes are needed in ELBW infants.
  • Masahiro Hayakawa, Yushi Ito, Shigeru Saito, Nobuaki Mitsuda, Sigeharu Hosono, Hitoshi Yoda, Kazutoshi Cho, Katsufumi Otsuki, Satoshi Ibara, Katsuo Terui, Kouji Masumoto, Takeshi Murakoshi, Akihito Nakai, Mamoru Tanaka, Tomohiko Nakamura
    PEDIATRICS INTERNATIONAL 56 2 215 - 221 2014年04月 [査読有り][通常論文]
     
    BackgroundHypoxic-ischemic encephalopathy (HIE) is one of the most critical pathologic conditions in neonatal medicine due to the potential for neurological deficits in later life. We investigated the incidence of term infants with moderate or severe HIE in Japan and identified prognostic risk factors for poor outcome in HIE. MethodsData on 227 infants diagnosed with moderate or severe HIE and born between January and December 2008 were collected via nationwide surveys from 263 responding hospitals. Using logistic regression, we examined the relationship between maternal, antepartum, intrapartum, and neonatal risk factors and clinical outcome at 18 months following birth. ResultsIn Japan, the incidence of moderate or severe HIE was 0.37 per 1000 term live births. Outborn births, low Apgar score at 5min, use of epinephrine, and low cord blood pH were intrapartum factors significantly associated with neurodevelopmental delay and death at 18 months. Serum lactate, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase (all, P < 0.001) and creatine kinase (P = 0.002) were significantly higher in infants with poor outcome compared to those with favorable outcomes. Abnormal brain magnetic resonance imaging (MRI), an important prognostic factor, was significantly associated with poor outcome (odds ratio, 11.57; 95% confidence interval: 5.66-23.64; P < 0.001). ConclusionsRisk factors predicting poor outcome in HIE include outborn birth, low Apgar score at 5min, use of epinephrine, laboratory abnormalities, and abnormal MRI findings.
  • N. Nagano, T. Okada, R. Fukamachi, K. Yoshikawa, S. Munakata, Y. Usukura, S. Hosono, S. Takahashi, H. Mugishima, M. Matsuura, T. Yamamoto
    Journal of Developmental Origins of Health and Disease 4 6 507 - 512 2013年12月 [査読有り][通常論文]
     
    Low birth weight was associated with cardiometabolic diseases in adult age. Insulin-like growth factor-1 (IGF-1) has a crucial role in fetal growth and also associates with cardiometabolic risks in adults. Therefore, we elucidated the association between IGF-1 level and serum lipids in cord blood of preterm infants. The subjects were 41 consecutive, healthy preterm neonates (27 male, 14 female) born at < 37-week gestational age, including 10 small for gestational age (SGA) infants (< 10th percentile). IGF-1 levels and serum lipids were measured in cord blood, and high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC) and very low-density lipoprotein triglyceride (VLDLTG) levels were determined by HPLC method. SGA infants had lower IGF-1 (13.1 ± 5.3 ng/ml), total cholesterol (TC) (55.0 ± 14.8), LDLC (21.6 ± 8.3) and HDLC (26.3 ± 11.3) levels, and higher VLDLTG levels (19.0 ± 12.7 mg/dl) than in appropriate for gestational age (AGA) infants (53.6 ± 25.6, 83.4 ± 18.9, 36.6 ± 11.1, 38.5 ± 11.6, 8.1 ± 7.0, respectively). In simple regression analyses, log IGF-1 correlated positively with birth weight (r = 0.721, P < 0.001), TC (r = 0.636, P < 0.001), LDLC (r = 0.453, P = 0.006), and HDLC levels (r = 0.648, P < 0.001), and negatively with log TG (r = -0.484, P = 0.002) and log VLDL-TG (r = -0.393, P = 0.018). Multiple regression analyses demonstrated that IGF-1 was an independent predictor of TC, HDLC and TG levels after the gestational age and birth weight were taken into account. In preterm SGA infants, cord blood lipids profile altered with the concomitant decrease in IGF-1 level. © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2013.
  • Tomoo Okada, Nobuhiko Nagano, Shigeharu Hosono
    JOURNAL OF CLINICAL LIPIDOLOGY 7 5 531 - 532 2013年10月 [査読有り][通常論文]
  • Shun Munakata, Tomoo Okada, Aya Okahashi, Kayo Yoshikawa, Yukihiro Usukura, Masami Makimoto, Shigeharu Hosono, Shigeru Takahashi, Hideo Mugishima, Yoshitaka Okuhata
    BRAIN & DEVELOPMENT 35 1 10 - 16 2013年01月 [査読有り][通常論文]
     
    Gray matter develops rapidly during the third trimester of pregnancy, which is a critical period for lipid deposition. We measured brain volume in term and late-preterm infants to determine if it is related to disabilities in late-preterm infants. In addition, we measured serum lipid concentrations to investigate the relationship between brain volume and lipid nutrition. Magnetic resonance imaging scans were obtained in 16 late-preterm and 13 term infants. We measured cerebrum, gray matter, and white matter volumes. We performed serum cholesterol, triglyceride (TG), and lipoprotein analyses in cord blood by high-performance liquid chromatography using gel permeation columns to assess lipid nutritional levels. The gray matter volume and percent cerebrum volume of gray matter were significantly smaller in late-preterm infants (p < 0.001). Head circumference and cerebrum and white matter volume did not differ between the two groups. Gray matter volume correlated positively with gestational age (r = 0.647, p < 0.001), head circumference (r = 0.688, p < 0.001), and high-density lipoprotein (HDL)-TG levels (r = 0.496, p = 0.006). Late-preterm infants had a normal head circumference and a lower gray matter volume than term infants. Gestational age and head circumference were significantly associated with gray matter volume. Only HDL-TG levels were significantly associated with gray matter volume. HDL-TG might contribute to the transport of fatty acids and gray matter development during the postnatal period. Thus, delayed gray matter development may partly contribute to neurodevelopmental disabilities in late-preterm infants. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
  • Uoshikawa K, Okada T, Munakata S, Okahashi A, Yonezawa R, Makimoto M, Takahashi S, Mugishima H, Yamamoto T
    Eur J Clin Nutr 18 109-12  2010年03月 [査読有り][通常論文]
  • Ryuta Yonezawa, Tomoo Okada, Tomomi Kitamura, Hidetoshi Fujita, Ikuhiro Inami, Masami Makimoto, Shigeharu Hosono, Michiyoshi Minato, Shigeru Takahashi, Hideo Mugishima, Tatsuo Yamamoto, Naoki Masaoka
    METABOLISM-CLINICAL AND EXPERIMENTAL 58 5 704 - 707 2009年05月 [査読無し][通常論文]
     
    Human fetuses have markedly low levels of serum lipids and a unique lipoprotein profile with respect to quality, with low-density lipoprotein (LDL)-like particle as the dominant cholesterol carrier. However, little is known about triglyceride (TG) distribution. In addition, lipid metabolism is important in lung development, with indications that TG from very low-density lipoprotein (VLDL) is essential for surfactant synthesis. We investigated TG distribution in preterm neonate cord blood and the relationship of VLDL-TG levels with respiratory distress syndrome (RDS). The study included 103 appropriate-for-gestational-age neonates (61 males). We performed serum lipoprotein analyses in cord blood by high-performance liquid chromatography with gel permeation columns. Term neonates had low cord blood TG, an, concentrations distributed equally to the LDL and VLDL fractions. However, preterm neonates had even lower TG concentrations, with VLDL as the dominant carrier. The LDL-TG and high-density lipoprotein-TG concentrations in cord blood increased gradually with gestational age, but cord blood VLDL-TG concentrations increased dramatically from 32 to 34 weeks of gestational age. Neonates with RDS exhibited no RDS-specific lipoprotein profiled however, most were born before the timing of the dramatic VLDL-TG increase. Our results suggest that 34 weeks of gestation is a critical period for TG metabolism, indicating the need for evaluation of the lipid nutritional state in preterm neonates. (C) 2009 Elsevier Inc. All rights reserved.
  • 新生児医療施設に対する輸血用血液供給体制の問題点と対応.
    小山典久, 網塚貴介, 奥起久子, 川口千晴, 白川嘉継, 長和俊, 伊藤進
    日本未熟児新生児学会雑誌 265-272 2009年04月 [査読有り][通常論文]
  • Shigeharu Hosono, Tutomu Ohno, Hirofumi Kimoto, Masaki Shimizu, Shigeru Takahashi, Kensuke Harada
    PEDIATRICS INTERNATIONAL 51 1 79 - 83 2009年02月 [査読有り][通常論文]
     
    The aim of the present study was to assess 3 year auditory and neurodevelopmental outcomes of persistent pulmonary hypertension of the newborn (PPHN) before and after introducing inhaled nitric oxide (i-NO) therapy, and to detect the clinical factors affecting poor outcome. A retrospective historical cohort study of 26 survivors with PPHN with oxygenation index (OI) >= 25 (13 infants without i-NO therapy, control group; 13 with i-NO therapy, i-NO group) was performed. Auditory brainstem response (ABR) at 6 and 12 months and neurodevelopmental outcomes at 3 years of age were evaluated. ABR abnormalities at 6 months were observed in one infant in the i-NO group and six in the control group (P = 0.04). At 1 year, one infant in the i-NO group and two of six infants in the control group still had ABR abnormality. In the i-NO group, two children had abnormal neurodevelopmental outcomes, as compared with five children in the control group at 3 year follow up. Two children in the control group and no children in the i-NO group had hearing loss at 3 years of age. Hypocapnea (P = 0.04) and elevated creatine phosphokinase (P = 0.04) were found to be most predictive for neurodevelopmental abnormality. Avoidance of excessive hypocapnea via introduction of i-NO therapy might reduce both ABR and neurodevelopmental abnormalities.
  • Shigeharu Hosono, Ikuhiro Inami, Hidetoshi Fujita, Michiyoshi Minato, Shigeru Takahashi, Hideo Mugishima
    JOURNAL OF PERINATAL MEDICINE 37 1 79 - 84 2009年01月 [査読有り][通常論文]
     
    Aim: To investigate whether end-tidal CO2 monitoring is useful for more rapid recognition of tracheal vs. esophageal intubation as compared to standard clinical evaluation in very low birth weight infants during neonatal resuscitation at birth. Patients and methods: Forty infants were prospectively identified. Tracheal tube placement was evaluated either using an end-tidal CO2 monitor by an investigator not involved in the resuscitation, or by evaluation of clinical parameters by a resuscitation team unaware of the end-tidal CO2 data. The time taken to detect accurate placement of the tube using capnometory vs. clinical determination of tracheal or esophageal tube placement was compared. Results: A total of 54 intubations was analyzed from 40 neonates. End-tidal CO2 monitoring correctly identified all 40 tracheal and all 11 esophageal intubations with 100% accuracy. On the other hand, clinical evaluation demonstrated discrepancies in three cases. The mean time in seconds for capnographic determination was significantly faster than clinical determination for both tracheal (7.5 +/- 1.3 vs. 17.0 +/- 3.4, P < 0.01) and esophageal intubation (6.5 +/- 0.7 vs. 19.9 +/- 1.8, P < 0.01). Conclusion: Exhaled CO2 detection is a sensitive and accurate technique to confirm tracheal tube placement in very low birth weight infants during neonatal resuscitation.
  • Hosono S, Mugishima H, Fujita H, Hosono A, Okada T, Takahashi S, Masaoka N, Yamamoto T
    Arch Dis Child Fetal Neonatal Ed 94 2009年 [査読有り][通常論文]
  • Shigeharu Hosono, Tsutomu Ohno, Hirofumi Kimoto, Masaki Shimizu, Shigeru Takahashi, Kensuke Harada
    PEDIATRICS INTERNATIONAL 50 5 640 - 643 2008年10月 [査読有り][通常論文]
     
    Background: The purpose of the present paper was to identify the predictive factors for survival for out-born infants born between 23 and 24 weeks of gestation. Methods: Ninety-two infants born between 23 and 24 weeks' gestation who were admitted to a level III neonatal intensive care unit from 1987 to 2000, were retrospectively studied. Survival was defined as discharge from the neonatal intensive care unit. Logistic regression was done to determine which clinical factors were most predictive of survival. The independent variables that were entered into the models were determined by preliminary univariate analysis. Results: Ninety-two infants were enrolled in the present study, 49 of whom survived in the surfactant era. The four variables that were found to be most predictive for survival on logistic regression were systolic blood pressure at 6 h (odds ratio [OR], 1.3; 95% confidence interval [CI]: 1.11-1.44 1 mmHg), ventilatory index < 0.047 (OR, 4.8; 95%CI: 1.07-21.65), initial hemoglobin value (OR, 1.6; 95%CI: 1.09-2.34/1 g/dL), and base excess at 6 h (OR, 2.1; 95%CI: 1.08-1.84/5 mEq/L). Conclusions: A total of 53.2% of infants delivered between 23 and 24 weeks of gestation survived at discharge after introduction of surfactant replacement therapy. Early cardiopulmonary adaptation and initial hemoglobin value are key factors for survival in infants born at 23-24 weeks of gestation.
  • Shigeharu Hosono, Tsutomu Ohno, Hirofumi Kimoto, Masaki Shimizu, Shigeru Takahashi, Kensuke Harada
    PEDIATRICS INTERNATIONAL 50 5 640 - 643 2008年10月 [査読有り][通常論文]
     
    Background: The purpose of the present paper was to identify the predictive factors for survival for out-born infants born between 23 and 24 weeks of gestation. Methods: Ninety-two infants born between 23 and 24 weeks' gestation who were admitted to a level III neonatal intensive care unit from 1987 to 2000, were retrospectively studied. Survival was defined as discharge from the neonatal intensive care unit. Logistic regression was done to determine which clinical factors were most predictive of survival. The independent variables that were entered into the models were determined by preliminary univariate analysis. Results: Ninety-two infants were enrolled in the present study, 49 of whom survived in the surfactant era. The four variables that were found to be most predictive for survival on logistic regression were systolic blood pressure at 6 h (odds ratio [OR], 1.3; 95% confidence interval [CI]: 1.11-1.44 1 mmHg), ventilatory index < 0.047 (OR, 4.8; 95%CI: 1.07-21.65), initial hemoglobin value (OR, 1.6; 95%CI: 1.09-2.34/1 g/dL), and base excess at 6 h (OR, 2.1; 95%CI: 1.08-1.84/5 mEq/L). Conclusions: A total of 53.2% of infants delivered between 23 and 24 weeks of gestation survived at discharge after introduction of surfactant replacement therapy. Early cardiopulmonary adaptation and initial hemoglobin value are key factors for survival in infants born at 23-24 weeks of gestation.
  • . 胎便関連性腸閉塞の診断と治療 外科からみた胎便関連性腸閉塞.
    越永従道, 南郷容子, 星野真由美, 井上幹也, 杉藤公信, 池田太郎, 草深竹志, 藤田英寿, 嶋田優美, 湊通嘉, 岡田知雄
    日本周産期・新生児医学会雑誌 44 943-947  2008年07月 [査読有り][通常論文]
  • Shigeharu Hosono, Hideo Mugishima, Tomomi Kitamura, Ikuhiro Inami, Hidetoshi Fujita, Ako Hosono, Michiyoshi Minato, Tomo Okada, Shigeru Takahashi, Kensuke Harada
    PEDIATRICS INTERNATIONAL 50 3 306 - 311 2008年06月 [査読有り][通常論文]
     
    Background: The aim of the present paper was to investigate the effect of initial hemoglobin level on red blood cell transfusion and neonatal adaptation in extremely low-birthweight (ELBW) infants. Methods: Subjects consisted of 54 ELBW infants admitted to level III neonatal intensive care unit between 1995 and 2000, and divided into two groups based on hemoglobin level at birth. Hi h hemoglobin was defined as hemoglobin 9 >= 15.0 g/dL. Results: There were no significant differences in gestational age and birthweight between the high hemoglobin group (n = 28) and low hemoglobin group (n = 26). The high hemoglobin group had decreased probability of requiring red blood cell transfusion (P < 0.05) and number of red blood cell transfusions (P < 0.05). Mortality rate in the low hemoglobin group was significantly higher compared with the high hemoglobin group (P = 0.03). In the high hemoglobin group, blood pressures during the first 24 h were significantly higher (P < 0.05) and the risk of intraventricular hemorrhage was significantly lower (P = 0.04) compared with the low hemoglobin group. The predictive variables, initial hemoglobin level (odds ratio 1.93 [decrease by I g/dL]) and intraventricular hemorrhage >= III (odds ratio 21.76 [positive]) were found to be most predictive for death on logistic regression. Conclusion: High hemoglobin level at birth is associated with a significantly reduced requirement for red blood cell transfusion and might contribute to stabilization of blood pressure, and thus reduce mortality and the risk of severe intraventricular hemorrhage.
  • H. Fujita, T. Okada, I. Inami, M. Makimoto, S. Hosono, M. Minato, S. Takahashi, H. Mugishima, T. Yamamoto
    JOURNAL OF PERINATOLOGY 28 5 335 - 340 2008年05月 [査読有り][通常論文]
     
    Objective: To investigate natural change of low-density lipoprotein (LDL) profile during the neonatal period and the impact of gestational age and birth weight on those changes. Study Design: We measured lipid composition in LDL fraction, LDL particle size and apolipoprotein B (apoB) concentration at birth, 5 days of age and 1 month of age in 63 healthy neonates that had 37 to 41-week gestational age. Result: Low-density lipoprotein cholesterol and apoB concentrations increased from birth to 5 days of age, and the concentration persisted at 1 month in breast-fed and mixed-fed infants. However, in formula-fed infants, the concentration decreased at 1 month. At 5 days of age, neonates had larger and more triglyceride (TG)-rich LDL particles than at birth. At 1 month of age, LDL particles were smaller and more cholesterol rich than at 5 days of age. Single regression analyses showed that gestational age had influenced the LDL profile at birth and 5 days of age, while at 1 month milk determined the profile. Conclusion: The number of LDL particles increased rapidly during the first 5 days of life, and the composition of LDL particles is modulated by TG content throughout the neonatal period. Gestational age and milk, rather than birth weight, determine postnatal changes in LDL profile.
  • Hidetoshi Fujita, Tomoo Okada, Ikuhiro Inami, Masami Makimoto, Shigeharu Hosono, Michiyoshi Minato, Shigeru Takahashi, Hideo Mugishima, Tatsuo Yamamoto
    CLINICA CHIMICA ACTA 389 1-2 93 - 97 2008年03月 [査読有り][通常論文]
     
    Background: Several subclasses of HDL are demonstrated to have different roles in atherosclerosis based on adult studies, but the significance of HDL heterogeneity in the fetus and neonate has not been clarified. It has been described that the cholesterol supply from apoE-rich HDL is essential for central nerve system neuron growth. Methods: Sixty-five healthy, term, appropriate for gestational age neonates (38 males and 27 females) were included in the study. Serum lipoprotein analyses were performed by HPLC with gel permeation columns, which classified HDL into 5 subgroups (i.e., very large, large, medium, small, and very small) on the basis of particle size. Apolipoprotein A-I, B, and E were also determined by turbidimetric immunoassay. Results: Cord blood has higher very large and very small HDL-cholesterol levels. Cord blood apolipoprotein E was not uniformly distributed in the HDL subclasses, with a strong association with very large HDL-cholesterol levels (males, r=0.548, p<0.001; females, r=0.631, p<0.01). However, the association disappeared by I month of age in males; in females, the association remained during the neonatal period. Conclusions: These results suggest that HDL may play the role of a dominant cholesterol carrier in the human fetus, and very large HDL-cholesterol have some contribution to the neurodevelopment in the fetus and neonates because of the close relationship with apolipoprotein E levels. (C) 2007 Elsevier B.V. All rights reserved.
  • Masao Murabayashi, Michiyoshi Minato, Yoshitaka Okuhata, Masami Makimoto, Shigeharu Hosono, Naoki Masaoka, Tomoo Okada, Tatsuo Yamamoto, Hideo Mugishima, Shigeru Takahashi, Kensuke Harada
    PEDIATRICS INTERNATIONAL 50 1 17 - 22 2008年02月 [査読有り][通常論文]
     
    Background: The purpose of the present study was to evaluate the usefulness of serum S100B as a clinical marker of intracranial lesions in newborns. Methods: The study involved 22 normal and 40 diseased newborns. Serum S100B level was measured on days 1 and 6 in normal newborns. Diseased newborns were classified into four groups: birth asphyxia with hypoxic-ischemic encephalopathy (HIE); birth asphyxia without HIE; intracranial hemorrhage (mainly subarachnoid); and brain malformation. In each group the serum S100B level was measured on days 1, 2 and 6. Development was also assessed to investigate the relation between serum S100B level and prognosis at 18 months after birth. Results: In normal newborns, serum S100B level was significantly higher in those with liquor to meconium stain than in those without. In diseased newborns, serum S100B level on day 1 was significantly higher in the HIE group than in all other groups (P < 0.05). There was no significant difference in serum S100B level between control and intracranial hemorrhage, or brain malformation. In newborns with birth asphyxia, serum S100B level was significantly higher in severe birth asphyxia than in mild or moderate birth asphyxia; two newborns with serum S100B level >= 10 mu g/L on days 1 and 2 developed cerebral palsy, others with no increase of S100B were all developing normally. Conclusions: Serum S100B level is a useful marker of acute perinatal brain damage, and is particularly valuable for fetal distress. In newborns with birth asphyxia, serum S100B levels serve as a biochemical marker of HIE.
  • S. Hosono, H. Mugishima, H. Fujita, A. Hosono, M. Minato, T. Okada, S. Takahashi, K. Harada
    ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION 93 1 F14 - F19 2008年01月 [査読有り][通常論文]
     
    Objective: To investigate the effects of umbilical cord milking on the need for red blood cell (RBC) transfusion and morbidity in very preterm infants. Patients and Methods: 40 singleton infants born between 24 and 28 weeks' gestation were randomly assigned to receive umbilical cord clamped either immediately (control group, n = 20) or after umbilical cord milking (milked group, n = 20). Primary outcome measures were the probability of not needing transfusion, determined by Kaplan-Meier analysis, and the total number of RBC transfusions. Secondary outcome variables were haemoglobin value and blood pressure at admission. Results: There were no significant differences in gestational age and birth weight between the two groups. The milked group was more likely not to have needed red cell transfusion (p = 0.02) and had a decreased number (mean (SD)) of RBC transfusions (milked group 1.7 (3.0) vs controls 4.0 (4.2); p = 0.02). The initial mean (SD) haemoglobin value was higher in the milked group (165 (14) g/l) than in the controls (141 (16) g/l); p<0.01). Mean (SD) blood pressure at admission was significantly higher in the milked group (34 (9) mm Hg) than in the controls 28 (8) mm Hg; p = 0.03). There was no significant difference in mortality between the groups. The milked group had a shorter duration of ventilation or supplemental oxygen than the control group. Conclusion: Milking the umbilical cord is a safe procedure, reducing the need for RBC transfusions, and the need for circulatory and respiratory support in very preterm infants.
  • Ikuhiro Inami, Tomoo Okada, Hidetoshi Fujita, Masami Makimoto, Shigeharu Hosono, Michiyoshi Minato, Shigeru Takahashi, Kensuke Harada, Tatsuo Yamamoto
    PEDIATRIC RESEARCH 61 5 604 - 606 2007年05月 [査読有り][通常論文]
     
    In term neonates, the adiponectin concentration is higher than it is in adults. To determine the relationship between adiponectin and early neonatal growth in a cohort study. Fifty-two neonates at term were studied. Serum adiponectin concentrations, body sizes, and skinfold thicknesses were measured at birth and at I mo of age. At birth, cord blood adiponectin concentration correlated positively with birth weight (r = 0.484, p = 0.0003), birth length (r = 0.524, p < 0.0001), and sum of the four skinfold thickness measurements (r = 0.378, p = 0.0057). In a stepwise regression, birth length was the only determinant of cord blood adiponectin concentration. However, at I mo of age, serum adiponectin concentration correlated with no anthropometric parameter at all. Between birth and I mo of age, the individual change in adiponectin concentration correlated negatively with birth weight. Thus, serum adiponectin concentrations in cord blood have a strong relationship to birth length rather than to body fatness, and this relationship is not demonstrated in 1-mo-old infants. These results imply that hormonal, substrate, or other mechanisms that regulate the relationship between body composition and growth in fetal life are different from those governing these relationships in early postnatal life.
  • Shigeharu Hosono, Hideo Mugishima, Masami Shimada, Michiyoshi Minato, Tomo Okada, Shigeru Takahashi, Kensuke Harada
    PEDIATRICS INTERNATIONAL 48 6 572 - 576 2006年12月 [査読有り][通常論文]
     
    Background: The purpose of the present paper was to detect the clinical factors most predictive of red blood cell (RBC) transfusion in extremely low-birthweight (ELBW) infants in the recombinant human erythropoietin era. Methods: Between 1995 and 2000, 66 ELBW infants were admitted to a level III neonatal intensive care unit. Fifty-four of 66 infants were eligible for enrollment in the present study. Infants were treated with erythropoietin 200 IU/kg per dose s.c. twice a week with 4-6 mg/kg per day iron supplement. Results: The mean gestational age and birthweight were 26.5 +/- 2.1 weeks and 776 +/- 134 g, respectively. Ten of 54 ELBW infants (18.5%) died during the first 21 days. Eight of 10 dead infants (80.0%) and 27 of 44 surviving infants (61.4%) received one or more RBC transfusions. The overall requirement for RBC transfusions in the surviving infants was 3.0 +/- 3.2 per infant/hospital course (range: 0-9) . There were significant differences in gestational weeks, birthweight, initial hemoglobin value, 5 min Apgar score, phlebotomy loss, phlebotomy loss/birthweight, duration of mechanical ventilation, duration of oxygen supplement, and incidence of both intraventricular hemorrhage and chronic lung disease between the transfused and non-transfused group. The predictive variables, initial hemoglobin level (odds ratio [OR] 2.61; 1 g/dL), birthweight (OR 3.00; 100 g), and gestational week (OR 1.89; 1 week), were found to be most predictive for transfusion on logistic regression analysis. Conclusions: ELBW infants are still the population at greatest risk for repeated blood transfusions after introduction of erythropoietin treatment. If labor develops, it is often impossible to extend the pregnancy period, therefore efforts should be made to increase hemoglobin level at birth.
  • S Hosono, A Hosono, H Mugishima, Y Nakano, M Minato, T Okada, S Takahashi, K Harada
    PEDIATRICS INTERNATIONAL 48 2 178 - 180 2006年04月 [査読無し][通常論文]
  • Shigeharu Hosono, Tsutomu Ohno, Hirofumi Kimoto, Masaki Shimizu, Kensuke Harada
    Pediatrics International 48 1 33 - 39 2006年02月 [査読有り][通常論文]
     
    Background: The purpose of the present paper was to evaluate the mortality and morbidity of infants born at 22-24 weeks gestation. Methods: A total of 78 infants born at 22-24 weeks gestation, who were admitted between January 1991 through December 2000, were retrospectively studied. Results: Seventy-one of 78 infants were enrolled in the present study. One year survival rates at 22, 23 and 24 weeks were 40.0% (2/5), 61.1% (11/18), and 50.0% (24/48), respectively. Failure of response to surfactant and air leak were associated with death in infants born at 23 weeks gestation. Low Apgar score, intraventricular hemorrhage (≥III), and sepsis were correlated with death in infants born at 24 weeks gestation. The handicap rates of survivors born at 22, 23, and 24 weeks gestation were 100, 36.4, and 26.1%, respectively. Conclusions: The present study indicates that infants born at 22 weeks gestation, in whom pulmonary structure is established, that is, a viable lung that can exchange gas with exogenous surfactant, have a chance to survive, but neurological outcome is still poor. Every possible effort should be made to extend gestation beyond 22 weeks.
  • Shigeharu Hosono, Tutomu Ohno, Hirofumi Kimoto, Masaki Shimizu, Shigeru Takahashi, Kensuke Harada
    JOURNAL OF PERINATAL MEDICINE 34 4 333 - 337 2006年 [査読有り][通常論文]
     
    Aim: To determine whether inhaled nitric oxide might reduce the need for excessive respiratory alkalosis to maintain systemic oxygenation in infants with persistent pulmonary hypertension of the newborn (PPHN). Materials and methods: A retrospective historical cohort study of 34 infants with PPHN with oxygenation index (OI) of 25 or more, including 19 infants without inhaled nitric oxide (i-NO) therapy (control group) and 15 infants with inhaled nitric oxide therapy (i-NO group) was performed. The initial dose of 10 ppm of i-NO was administered and no responders received the maximum dose of 25 ppm. We evaluated the mortality rate and the change of OI index and PaCO2 during the first 6 days. Results: There were no significant differences in characteristics between groups. Two of 15 in the i-NO group and 6 of 19 infants in the control group died during the first 48 h. Baseline OI, PaCO2 and arterial pH were similar in the two groups. OI in the i-NO group was significantly higher than in the control group between 12 and 96 h. PaCO2 in the i-NO group was higher than in the control group between 24 and 144 h. Conclusion: i-NO therapy for PPHN might improve systemic oxygenation without excessive hypocapnia. However there was no reduction in duration of ventilation support or oxygen supply.
  • 臍帯血自己血輸血確立に向けての臨床的検討 第2報 超低出生体重児における臍帯血自己血輸血の必要性
    細野茂春, 稲見育大, 藤田英寿, 田口順教, 嶋田優美, 湊 通嘉, 岡田知雄, 高橋 滋, 原田研介, 麦島秀雄, 山本樹生
    日本産婦人科・新生児血液学会 14 2 25-28  2005年 [査読有り][通常論文]
  • Hosono S, Mugishima H, Nakano Y, Murabayashi M, Shimada M, Minato M, Takahashi S, Harada K, Ikeda T, Fukuzawa M
    Journal of Perinatl Medicine 32 2 187-189  2004年 [査読有り][通常論文]
  • Effect of milking of umbilical cord on transfusion in extremely low birth weight infants
    Hosono S, Inami I, Fujita H, Tanaka H, Taguchi M, Shimada M, Minato M, Okada T, Mugishima H, Takahashi S, Harada K
    Medimond 2004年 [査読無し][通常論文]
  • 超低出生体重児における赤血球MAP分割製剤導入による供血者の削減効果
    細野茂春, 村林督夫, 嶋田優美, 湊 通嘉, 岡田知雄, 高橋 滋, 原田研介, 麦島秀雄
    日本産婦人科・新生児血液学会誌 13 2 1-4  2003年 [査読有り][通常論文]
  • 臍帯血自己血輸血確立に向けての臨床的検討―第1報 新生児外科疾患における臍帯血自己血輸血の適応と有用性
    細野茂春, 中野優子, 村林督夫, 嶋田優美, 湊 通嘉, 岡田知雄, 高橋 滋, 原田研介, 池田太郎, 福澤正洋, 山本樹生, 麦島秀雄
    日本産婦人科・新生児血液学会誌 12 2 21-27  2002年 [査読有り][通常論文]
  • No clinical correlation between bilirubin levels and severity of retinopathyof prematunity
    Hosono S, Ohno T, Kimoto H, Shimizu M, Nozawa M, Genkawa R, Yoshida T, Wada S, Harada K
    Pediatric Ophthalmology & Strabismus 39 3 151-156  2002年 [査読無し][通常論文]
  • Hosono S, Ohno T, Kimoto H, Nagoshi R, Shimizu M, Nozawa M, Harada K
    Pediatrics International 44 5 21-27  2002年 [査読有り][通常論文]
  • Hosono S, Fuyama Y, Ohno T, Kishimoto H, Ogawa Y
    Journal of Perinatl Medicine 30 3 265-268.  2002年 [査読有り][通常論文]
  • 在胎25週未満時の累積生存率と予後因子の検討
    細野茂春, 大野 勉, 鬼本博文, 清水正樹, 野沢政代, 源川隆一, 吉田朝秀
    周産期シンポジウム 19 9-18  2001年 [査読有り][通常論文]
  • 胎便吸引症候群の臨床的検討 重症化予測因子についての解析
    源川隆一, 吉田朝秀, 野澤政代, 清水正樹, 細野茂春, 鬼本博文, 大野勉
    埼玉小児医療センター医学誌 17 2 101-104  2001年 [査読有り][通常論文]
  • FISH解析が過剰マーカー染色体の同定に有用であった非典型的cat eye症候群の1症例
    古庄知己, 松嶋一成, 浦島崇, 三井規雅, 武藤玲子, 細野茂春, 大野勉, 小川潔, 西田俊朗, 大橋博文
    埼玉小児医療センター医学誌 17 2 17-23  2001年 [査読有り][通常論文]
  • Hosono S, Ohno T, Kimoto H, Nagoshi R, Shimizu M, Nozawa M
    Pediatrics International 43 1 8-11  2001年 [査読有り][通常論文]
  • Hosono S, Imura S, Akiyama K, Takigawa I, Ishizeki S, Takeda H
    Pediatrics International 43 1 16-19  2001年 [査読有り][通常論文]
  • Hosono S, Ohono T, Kimoto H, Nagoshi R, Shimizu M, Nozawa M
    Pediatrics International 43 5 465-8.  2001年 [査読有り][通常論文]
  • Pediatrics International 43 1 78-80.  2001年 [査読有り][通常論文]
  • Hosono S, Ohno T, Ojima K, Kimoto H, Nagoshi R, Shimizu M, Nozawa M
    Pediatrics International 42 4 372-374  2000年 [査読有り][通常論文]
  • 過去10年間のシリンジポンプの故障状況に関する検討
    松井晃, 小池龍平, 古山義明, 大野強, 細野茂春
    埼玉小児医療センター医学誌 15 2 8-12  1999年 [査読有り][通常論文]
  • アルギニノコハク酸尿症の同胞例
    金田朋治, 布山裕一, 野沢政代, 細野茂春, 名越廉, 鬼本博文, 大野勉, 山口修一, 望月弘, 甲田直也, 増永健
    埼玉小児医療センター医学誌 15 2 35-39  1999年 [査読有り][通常論文]
  • 埼玉県の国際医療協力 ネパール,バクタプール郡病院の小児科入院に関して
    望月弘, 今立明宏, 大橋博文, 細野茂春, 岡崎実, 鍵本聖一, 小川潔, 奈良隆寛, 松永光平, 大石勉, 大野勉, 山口修一, 城宏輔, 赤司俊二, 山本圭子, 植田哲生, 長谷川俊博, 謝村錦芳, 浅井澄代, 野田修治, 大村外志隆
    埼玉県医学会雑誌 33 3 380-383  1999年 [査読有り][通常論文]
  • 新生児Leigh症候群の1例
    名越廉, 金田朋治, 布山裕一, 野澤政代, 細野茂春, 鬼本博文, 大野勉, 相原敏則, 赤司俊二
    埼玉県医学会雑誌 33 3 350-353  1999年 [査読無し][通常論文]
  • 脳室周囲白質軟化症と運動発達
    今井祐之, 田中学, 岡藤隆夫, 奈良隆寛, 細野茂春, 大野勉
    埼玉小児医療センター医学誌 15 1 10-16  1999年 [査読有り][通常論文]
  • Hosono S, Ohno T, Kimoto H, Nagoshi R, Shimizu M, Nozawa M
    Pediatrics International 41 5 525-528  1999年 [査読有り][通常論文]
  • Successful transcutaneous arterial embolization of a giant hemangioma associated with high-output cardiac failure and Kasabach-Merritt syndrome in a neonate : A case report
    Hosono S, Ohno T, Kimoto H, Nagoshi R, Shimizu M, Nozawa M, Fuyama Y, Kaneda T, Moritani T, Aihara T
    Journal of perinatal medicine 27 5 399-403  1999年 [査読有り][通常論文]
  • バクタプール郡病院の小児科入院 Medical Recording Systemのデータより
    望月弘, 長谷川俊博, 謝村錦芳, 浅井澄代, 野田修治, 大村外志隆, 古川俊雄, 福島和之, 本間威, 松永光平, 鍵本聖一, 細野茂春, 岡崎実, 大橋博文, 奈良隆寛, 大石勉, 今立明宏, 城宏輔, 山本圭子
    埼玉小児医療センター医学誌 14 2 26-31  1998年 [査読有り][通常論文]
  • An evaluation of infants growth in the Kingdom of Nepal
    Hosono S, Okazaki M, Kagimoto S, Ogawa K, Matunaga K, Oishi T, Ohno T, Yamaguchi S, Joh K, Akashi S, Yamamoto K, Kohno S, Honma T, Shakya KN
    Acta Paediatrica Japonica 40 4 350-355  1998年 [査読有り][通常論文]
  • 彩の国の周生期医療第3編:当科における新生児死亡症例の検討
    岩井正憲, 大野 勉, 鬼本博文, 名越 廉, 細野茂春, 清水正樹, 野澤政代
    埼玉県立小児医療センター医学誌 14 15-20  1997年 [査読有り][通常論文]
  • 胎児水腫、著明な貧血、ショックを呈した一D一母体児の1例
    岩井正憲, 岩崎綾子, 石山敬子, 清水正樹, 永田涼子, 細野茂春, 鬼本博文, 大野 勉, 増田純一郎, 岸本宏志
    埼玉県立小児医療センター医学誌 14 36-40  1997年 [査読有り][通常論文]
  • Ze11weger症侯群の1例
    清水正樹, 岩井正憲, 野澤政代, 細野茂春, 鬼本博文, 大野 勉, 前川喜平
    埼玉県立小児医療センター医学誌 14 57-60  1997年 [査読無し][通常論文]
  • サーファクタント投与における脳循環動態の変化に関する検討
    鬼本博文, 大野 勉, 名越 廉, 細野茂春, 清水正樹, 野澤政代, 岩井正憲
    第15回サーファクタント研究会講演集 15 14-17  1997年 [査読無し][通常論文]
  • サーファクタント投与における脳循環動態の関する検討
    鬼本博文, 大野 勉, 名越 廉, 細野茂春, 清水正樹, 野澤政代, 岩井正憲
    埼玉県立小児医療センター医学誌 14 13-17  1997年 [査読無し][通常論文]
  • 新生児B群溶連菌髄膜炎11例の髄液所見、頭部CT所見と予後についての検討
    岩井正憲, 石山敬子, 清水正樹, 永田涼子, 細野茂春, 鬼本博文, 大野 勉
    埼玉県立小児医療センター医学誌 13 46-49  1996年 [査読有り][通常論文]
  • 阪神淡路大震災後の学童における身体的・心理的反応に関する検討(第1報)
    細野茂春, 鍵本聖一, 大野 勉, 赤司俊二, 河野三
    埼玉小児医療センター医学誌 12 1 25-29  1996年 [査読有り][通常論文]
  • 彩の国周産期医療 第一編:周産期医療システムと周産期医療センターの必要性
    大野 勉, 名越 廉, 鬼本博文, 細野茂春, 清水正樹, 野澤政代, 岩井正憲, 赤司俊二, 河野三郎
    埼玉県立小児医療センター医学誌 13 107-112  1996年 [査読無し][通常論文]
  • 超低出生体重児におけるサーファクタント補充療法無効例の検討
    細野茂春, 石山敬子, 岩井正憲, 清水正樹, 永田涼子, 鬼本博文, 勝又大助
    第13回肺サーファクタント研究会講演集 13 21-24  1995年 [査読無し][通常論文]
  • 小腸断裂をともなう壊死性腸炎を呈した1例
    岩井正憲, 清水正樹, 細野茂春, 大野 勉
    Neonatal care 9 45  1995年 [査読無し][通常論文]
  • Trace elements and mineral requirements for very low birth weight infants in rickets of prematurity.
    Takada M, Shimada M, Hosono S, Tauchi M, Minato M, Takahashi S, Okuni M, Takeuchi S
    Early Hum Dev 29 1 333-338.  1992年 [査読有り][通常論文]
  • 小児骨髄移植10症例の間質性肺炎について
    島田俊明, 細野茂春, 鈴木孝, 陳基明, 市川正孝, 藤沢孝人, 川田孝吉, 麦島秀雄
    臨床小児放射線学会雑誌 3 150-151  1987年12月 [査読有り][通常論文]

書籍

  • 査読者が伝授する論文投稿・査読のコツ: お作法を知ればこわくない
    細野茂春 ()
    メディカ出版 2017年04月 ISBN: 9784840461665
  • ここまで使える 新生児・小児のパルスオキシメトリ: SpO2の基本と応用
    細野茂春 (担当:共著)
    メディカ出版 2016年12月 ISBN: 9784840461214
  • 2015 CoSTRに基づいた新生児低体温療法実践マニュアル
    細野茂春 (担当:共著範囲:part03実践 01 NCPRから適応評価への流れ)
    東京医学社 2016年12月 ISBN: 9784885632723
  • 救急蘇生法の指針2015 医療従事者用
    細野茂春, 田村正徳 (担当:その他範囲:166-177)
    へるす出版 2016年11月 ISBN: 9784892698958
  • 日本版救急蘇生ガイドライン2015に基づく新生児蘇生法インストラクターマニュアル
    細野茂春 (担当:編者(編著者)範囲:3)
    メジカルビュー社 2016年05月 ISBN: 9784758317344 
    2015年10月16日に公表された「日本版救急蘇生ガイドライン2015」に則った最新情報を掲載した「第3版 新生児蘇生法テキスト」に対応したインストラクターマニュアルの第4版である。オールカラーの体裁で講習会の進め方をわかりやすく解説している。版を改めるに際し,NCPR修了認定者のための継続学習支援を目的としたSコースについての記述が追加され,そのために使用される自己チェックシートを付属した。また,シミュレーション教育やチームワークの考え方が追加され,NCPR講習会を開催するうえで必要なスキルを,最新の教育論に基づいてインストラクターが身につけられる書籍となっている。
  • 新生児のプライマリ・ケア
    細野茂春 (担当:共著範囲:第IV章分娩室での対応, 4. 分娩室内での身体診察)
    診断と治療社 2016年05月
  • 日本版救急蘇生ガイドライン2015に基づく新生児蘇生法テキスト
    細野茂春 (担当:共編者(共編著者)範囲:3、12-17、26-33)
    メジカルビュー社 2016年04月 ISBN: 9784758317320 
    日本蘇生協議会・日本救急医療財団合同委員会の作成による「日本版救急蘇生ガイドライン2015」に則った,「新生児蘇生法テキスト」の改訂版である。改訂に伴い,カラーイラストや写真を多用してデザインを一新し,基礎的事項から蘇生の実際まで,さらにわかりやすく解説されており,本書1冊で新生児蘇生手技を学ぶことができる。日本周産期・新生児医学会新生児蘇生法講習会の公式テキストに指定されており,予習・復習にも役立つ。出産に携わるすべての医療従事者必携の書
  • JRC蘇生ガイドライン2015
    細野茂春 (担当:共編者(共編著者)範囲:244-289)
    医学書院 2016年02月 ISBN: 9784260025089 
    各国の蘇生協議会を束ねる国際組織ILCORが5年ぶりに作成した国際コンセンサスであるCoSTRに基づいて、日本の実情にあわせて作成されたガイドライン最新版。日本蘇生協議会が総力をあげ、徹底的な議論を経て作り上げた。新たにファーストエイドの章が新設されたことをはじめ、すべての内容が改めて検討された。救急蘇生の現場に立つ、医師、看護師、救急救命士をはじめとする全ての人に必携のガイドライン。
  • 細野茂春 (担当:編者(編著者)範囲:24-51, 82-88, 102-155)
    メディカ出版 2015年11月 ISBN: 9784840454681
  • 救急蘇生法の指針2010医療従事者用
    (担当:共著範囲:147-156)
    ヘルス出版 2012年02月
  • JRC蘇生ガイドライン2010
    (担当:共著範囲:205-226)
    ヘルス出版 2011年11月
  • 新生児の症状・所見マスターブック
    (担当:単著範囲:285-289, 289-292,292-295)
    メディカ出版 2011年04月
  • EBM小児疾患の治療2011-2012
    (担当:共著範囲:666-672)
    中外医学社 2011年02月
  • 日本版救急蘇生ガイドライン2010に基づく新生児蘇生法テキスト(改訂第2版)
    (担当:共著範囲:98,100)
    メディカルビュー社 2011年01月 ISBN: 9784758310697
  • Regenerative Medicine Using Pregnancy-specific Biological Substances
    (担当:共著範囲:75-83)
    Springer London Ltd 2011年01月
  • 今日の治療指針2010
    (担当:単著範囲:1077)
    医学書院 2010年01月
  • 小児生理学(第3版)
    (担当:単著範囲:p102-113)
    へるす出版 2009年05月
  • 小児科学・新生児学テキスト(第5版)
    高橋 滋 (担当:共著範囲:725-727, 809-818)
    診断と治療社 2007年04月
  • NICUマニュアル(第4版),
    (担当:共著範囲:175-178)
    金原出版株式会社 2007年02月 ISBN: 9784307170536 
    ショック
  • NICUマニュアル(第3版)
    (担当:共著範囲:398-402)
    金原出版株式会社 2001年09月
  • 新生児病の臨床新生児の血液・造血器・免疫疾患
    細野茂春 (担当:単著範囲:201-207)
    金原出版株式会社 1994年

講演・口頭発表等

  • 「学習のススメ」ー新生児蘇生法普及事業の新しい学習支援-制度改革とeラーニング-  [通常講演]
    第14回新生児呼吸療法モニタリングフォーラム 2012年02月 口頭発表(一般)
  • 新生児期皮下脂肪蓄積とcatch upに関するIGF-1とLPLの意義  [通常講演]
    第24回小児脂質研究会 2011年11月 口頭発表(一般)
  • 経皮ガス分圧モニターからわかる赤ちゃんの変化.  [通常講演]
    第47回日本周産期・新生児医学会総会, 2011年07月 口頭発表(一般)
  • 新生児蘇生法におけるEtCO2の意義 -TcPCO2、血液ガス分析との比較を踏まえて-『NICUにおける経皮ガスモニタおよび血液ガス分析ガイドライン作成に向けてその(1)今の日本の現状』  [通常講演]
    第13回新生児呼吸療法モニタリングフォーラム 2011年02月 口頭発表(一般)
  • 循環1  [通常講演]
    第55回日本未熟児新生児学会 2010年11月 ポスター発表 日本未熟児新生児学会
  • 新たな新生児蘇生手技の提言 ―多施設共同研究による臍帯ミルキングの効果の実証と臨床研究実施上の問題点  [通常講演]
    田村正徳
    第55回日本未熟児新生児学会 2010年11月 口頭発表(一般) 日本未熟児新生児学会
  • 赤血球輸血トリガーポイント 国内・国際比較  [通常講演]
    新生児輸血のガイドライン作成を目指した意見収集と情報交換 2010年11月 口頭発表(一般) 厚生労働科学研究 星班 拡大班会議
  • Perinatal-neonatal care system  [通常講演]
    Danhun Wang
    The International Symposium of Neonatal Respiratory and Intensive Care Medicine 2010年10月 口頭発表(一般)
  • Effect of umbilical cord milking as placental transfusion at delivery room resuscitation  [通常講演]
    The International Symposium of Neonatal Respiratory and Intensive Care Medicine 2010年10月 口頭発表(一般)
  • A role of end-tidal CO 2 detection for assessment of tracheal intubations  [通常講演]
    The International Symposium of Neonatal Respiratory and Intensive Care Medicine 2010年10月 口頭発表(一般)
  • Late preterm 児はRSV感染症のローリスク児か?-医療受給者の権利をどうかんがえるか-.  [通常講演]
    RSV Japan Global Experts’Meeting 2010 2010年06月 口頭発表(一般)
  • 医療安全におけるCO2 モニタリングの有用性  [通常講演]
    .第8回日本予防医学リスクマネージメント学会 2010年03月 口頭発表(一般)
  • Maternal and Child Health Handbook  [通常講演]
    Masami Makimoto, Shigeharu Hosono, Hideo Mugishima
    「平成21年度文部科学省国際協力イニシアティブ教育協力拠点形成事業−ラオス・ヘルスサイエンス大学教育支援ワーク・ショップー」 2010年02月 口頭発表(一般)
  • 臍帯血どうしていますか?-臍帯血利用の今後の展開-.  [通常講演]
    第24回おきなわ周産期セミナー 2009年10月 口頭発表(一般)
  • Future use of umbilical cord blood - The role of placental transfusion as resuscitation –  [通常講演]
    Perinatal Management Conference. 2009年09月 口頭発表(一般)
  • 新生児蘇生法としての臍帯ミルキング.  [通常講演]
    第19回日本産婦人科・新生児血液学会 2009年06月 口頭発表(一般)
  • Milking of the umbilical cord at resuscitation in extremely low birth weight infants  [通常講演]
    Hosono S
    15th Congress of the Federation of Asia and Oceania Perinatal Societies 2008年06月 その他
  • 新しい新生児蘇生法のガイドライン-Consensus2010に向けての提言-超低出生体重児の臍帯ミルキング  [通常講演]
    細野茂春
    第10回新生児呼吸療法・モニタリングフォーラム 2008年02月 その他
  • 超低出生体重児における赤血球MAP分割製剤導入による供血者の減少効果-血液製剤の有効利用-  [通常講演]
    細野茂春, 湊通嘉, 岡田知雄, 高橋滋, 麦島秀雄
    第52回日本未熟児新生児学会 2007年11月 その他
  • Utility of end-tidal CO2 monitoring for assessment of tracheal intubation during neonatal resuscitation at birth  [通常講演]
    Hosono S, Kitamura T, Fujita Hmakimoto M, Minato M, Okada T, Takahasahi S, Mugishima H
    The 8th International Congress of Perinatal Medicine 2007年09月 口頭発表(一般)
  • 早産児の予後  [通常講演]
    .第2回日本早産予防研究会 2007年07月 口頭発表(一般)
  • 超早産児の臍帯ミルキングによる赤血球輸血の回避効果  [通常講演]
    .第18回小児輸血療法研究会 2007年07月 口頭発表(一般)
  • End-tidal CO2モニターによる出生時気管挿管の確認―ガイドライン2005の提言からー  [通常講演]
    細野茂春, 知念詩乃, 米沢龍太, 木多村知美, 藤田英寿, 嶋田優美, 湊 通嘉, 岡田知雄, 高橋 滋, 原田研介
    第110回日本小児科学会学術集会 2007年04月 その他
  • 臍帯ミルキング  [通常講演]
    . 第15回静岡中部周産期勉強会 2007年03月 口頭発表(一般)
  • 終末呼気CO2モニタによる気管挿管の確認-ガイドライン2005の提言から- (シンポジウム:これからのベットサイドモニタリング).  [通常講演]
    細野茂春
    第9回新生児呼吸療法・モニタリングフォーラム 2007年02月 その他
  • 極低出生体重児における臍帯のミルキングによる赤血球輸血の減少効果  [通常講演]
    細野茂春, 小高美奈子, 吉川香代, 木多村知美, 宮林寛, 稲見育大, 藤田英寿, 嶋田優美, 湊通嘉, 岡田知雄, 麦島秀雄, 高橋滋, 原田研介, 宮川康司, 正岡直樹, 山本樹生
    第25回日本周産期・新生児学会周産期シンポジウム 2007年01月 口頭発表(一般)
  • 超低出生体重児における臍帯のミルキングによる輸血および生後の適応に関する効果  [通常講演]
    細野茂春, 木多村知美, 稲見育大, 藤田英寿, 嶋田優美, 湊通嘉, 岡田知雄, 麦島秀雄, 高橋滋, 原田研介
    第51回日本未熟児新生児学会 2006年11月 口頭発表(一般)
  • 終末呼気CO2モニタによる気管挿管の確認-ガイドライン2005の提言から-  [通常講演]
    第34 会日本救急医学会総会・学術集会 2006年10月 口頭発表(一般)
  • 長期経口摂取不良母体から出生し重度の出血傾向を呈した低出生体重児の一例  [通常講演]
    小高美奈子, 稲見育大, 宮林 寛, 細野茂春, 湊 通嘉, 麦島秀雄, 高橋 滋, 原田研介
    第16回日本産婦人科・新生児血液学会 2006年06月 口頭発表(一般)
  • エリスロポエチン導入後の1996年から2000年の5年間の極低出生体重児の輸血割合とエリスロポエチンの使用の現状  [通常講演]
    細野茂春, 小高美奈子, 吉川香代, 木多村知美, 藤田英寿, 嶋田優美, 湊 通嘉, 岡田知雄, 麦島秀雄, 高橋 滋, 原田研介
    第16回日本産婦人科・新生児血液学会 2006年06月 口頭発表(一般)
  • Effect of milking of umbilical cord on postpartum adaptation and anemia of prematurity infants weighing 1,000 to 1,499 g  [通常講演]
    S.Hosono, T Kitamura, H Fujita, H Miyabayashi, M Shimada, M Minato, T Okada, H Mugishima, S Takahassi, K Harada
    XX European Congress of Perinatal Medicne 2006年05月 口頭発表(一般)
  • 新生児肝炎症候群と胆道閉鎖症との鑑別における血漿フィブリノゲンの有用性について  [通常講演]
    湊 通嘉, 嶋田優美, 細野茂春, 陳基明, 住友直方, 岡田知雄, 麦島秀雄, 高橋 滋, 原田研介
    第109回日本小児科学会学術集会 2006年04月 ポスター発表
  • 胎内感染に伴う先天性単純ヘルペス感染症の双胎例  [通常講演]
    木多村知美, 吉川香代, 小高三奈子, 藤田英寿, 嶋田優美, 細野茂春, 湊 通嘉, 岡田知雄, 高橋 滋, 原田研介
    第109回日本小児科学会学術集会 2006年04月 ポスター発表
  • 新生児の痛覚についての検討(第1報)ー温痛覚計の有用性についてー  [通常講演]
    宮林 寛, 久富幹則, 嶋田優美, 細野茂春, 湊 通嘉, 岡田知雄, 麦島秀雄, 高橋 滋, 原田研介
    第109回日本小児科学会学術集会 2006年04月 ポスター発表
  • 臍帯血、新生児における大粒子サイズHDLの推移についてーリポ蛋白リモデリングの可能性  [通常講演]
    藤田英寿, 稲見育大, 岡田知雄, 嶋田優美, 細野茂春, 湊 通嘉, 麦島秀雄, 高橋 滋, 原田研介
    第109回日本小児科学会学術集会 2006年04月 口頭発表(一般)
  • 超低出生体重児における臍帯のmilkingと分割製剤導入による輸血回数および供血者数の減少効果  [通常講演]
    細野茂春, 小高美奈子, 吉川香代, 木多村知美, 宮林 寛, 嶋田優美, 湊 通嘉, 岡田知雄, 麦島秀雄, 高橋 滋, 原田研介
    第109回日本小児科学会学術集会 2006年04月 口頭発表(一般)
  • 超低出生体重児の循環動態の早期安定化に向けた臍帯のMilkingに関する検討  [通常講演]
    細野茂春, 宗像 俊, 稲見育大, 藤田英寿, 田中啓子, 嶋田優美, 湊 通嘉, 岡田知雄, 麦島秀雄, 原田研介, 正岡直樹, 山本樹生
    第24回日本周産期・新生児学会 周産期シンポジウム 2006年01月 口頭発表(一般)
  • 臍帯血自己血輸血の現状と展望  [通常講演]
    細野茂春
    第4回東京新生児研究会講演 2005年11月 その他
  • 臍帯血自己血輸血の現状と展望  [通常講演]
    第4回東京新生児研究会 2005年11月 口頭発表(一般)
  • Effect of Initial Hemoglobin value on Transfusion and Postpartum Adaptation in Extremely Low Birth Weight Infants in erythropoietin era  [通常講演]
    Hosono S, Mugishima H, Takahashi S, Shimada M, Minato M, Okada T, Harada K
    The 7th International Congress of Perinatal Medicine 2005年09月 口頭発表(一般)
  • Galloway-Mowat症候群と診断した低出生体重児の1例  [通常講演]
    大橋祥子, 藤田英寿, 稲見育大, 田中啓子, 田口順教, 嶋田優美, 細野茂春, 湊通嘉, 岡田知雄
    第108回日本小児科学会学術集会 2005年04月 ポスター発表
  • 脳低温療法導入に向けての基礎的検討(第1報)NICU環境温の変化に伴う表面体温、深部体温の変化  [通常講演]
    細野茂春, 稲見育大, 藤田英寿, 田中啓子, 田口順教, 牧本優美, 湊 通嘉, 岡田知雄, 麦島秀雄, 高橋 滋, 原田研介
    第49回日本未熟児新生児学会 2004年12月 ポスター発表
  • 超低出生体重児における臍帯Milkingの効果に関する研究(第2報)  [通常講演]
    細野茂春, 稲見育大, 藤田英寿, 田中啓子, 田口順教, 牧本優美, 湊 通嘉, 岡田知雄, 麦島秀雄, 高橋 滋, 原田研介
    第49回日本未熟児新生児学会 2004年12月 口頭発表(一般)
  • EFFECT OF MILKING OF UMBILICAL CORD ON TRANSFUSION IN EXTREMELY LOW BIRTH WEIGHT INFANTS  [通常講演]
    S Hosono, I Inami, H Fujita, H Tanaka, M Taguchi, M Shimada, M Minato, T Okada, H Mugishima, S Takahashi, K Harada
    XIX European Congress of Perinatal Medicine 2004年10月 ポスター発表
  • 超低出生体重児における臍帯Milkingの効果に関する研究(第1報)  [通常講演]
    細野茂春, 阿部 修, 田口順教, 牧本優美, 湊 通嘉, 岡田知雄, 高橋 滋, 原田研介
    第40回日本周産期・新生児医学会 2004年07月 口頭発表(一般)
  • 再発先天性横隔膜ヘルニアに対してMesh Plug and on lay sheetにて修復を行った1例  [通常講演]
    越永従道, 星野真由美, 井上幹也, 後藤博志, 池田太郎, 荻原紀嗣, 田口順教, 細野茂春, 湊通嘉
    第40回日本周産期・新生児医学会 2004年07月 ポスター発表
  • 未熟心筋における心筋組織性状診断 integrated beckscatterを用いて  [通常講演]
    阿部 修, 田口順教, 嶋田優美, 細野茂春, 湊通嘉, 高橋滋, 原田研介
    第40回日本周産期・新生児医学会 2004年07月 ポスター発表
  • 当総合周産期母子医療センターにおける出生体重1500g未満の鼠径ヘルニア  [通常講演]
    星野真由美, 後藤博志, 池田太郎, 越永従道, 湊通嘉, 嶋田優美, 細野茂春
    第40回日本周産期・新生児医学会 2004年07月 口頭発表(一般)
  • 超低出生体重児の出生時ヘモグロビン値が輸血回数および血圧におよぼす影響について  [通常講演]
    細野茂春, 阿部 修, 田口順教, 嶋田優美, 湊 通嘉, 岡田知雄, 高橋 滋, 原田研介, 麦島秀雄
    第14回日本産婦人科・新生児血液学会 2004年06月 口頭発表(一般)
  • Current Neonatal Medicine in JapanManagement of Extremely Low Birth Weight Infant  [通常講演]
    S. Hosono
    2004 Shanghai Neonatal Nursing Seminar 2004 2004年03月 その他
  • 在胎25週未満児の累積生存率と生存予後因子の検討  [通常講演]
    細野茂春, 鬼本博文, 勝又大助, 名越 廉, 烏山義仁, 大野 勉
    第19回日本周産期学会 2001年01月 その他
  • Variation of total and unbound bilirubin changes in the newborns with various type of illness and the effect of albumin administration on serum unbound bilirubin  [通常講演]
    Hosono S, Ohno T
    Research conference of Kernicterus in Japan-Strategy for Preventing Kernicterus 1999年11月 その他
  • 感染症によるunbound bilirubin測定の臨床的意義  [通常講演]
    細野茂春, 小嶋恭子, 岩村美佳, 永田涼子, 鬼本博文, 勝又大助, 名越 廉, 烏山義仁, 大野 勉
    第39回未熟児新生児学会 1994年10月 その他
  • New management of neonatal hyperbi1irubinemia  [通常講演]
    Hosono S, Ohno T
    Th 6th Japan-Zanbia Iinternational Pediatric Conference 1994年10月 その他
  • Unbound bilirubin in sick neonates  [通常講演]
    Hosono S
    International kernicterus symposium 1994年04月 その他
  • Management of health care in children  [通常講演]
    Hosono S
    JICA Nepal expert annual meeting 1991年03月 その他
  • ハイリスク新生児1238例の新生児集中治療施設退院後の再入院率,その原因,基礎疾患との関係,転帰などについて検討  [通常講演]
    秋山和範, 細野茂春, 石関しのぶ, 戸田顕彦, 金英哲, 越田利弘, 湊通嘉, 井村総一, 大国真彦
    第24回日本新生児学会 1988年07月 口頭発表(一般)
  • レスピレーター依存性Bronchopulmonary dysplasia(BPD)に対するDexamethasone療法  [通常講演]
    越田利弘, 江尻和夫, 細野茂春, 田内守之, 戸田顕彦, 石関しのぶ, 湊道嘉, 鈴木裕, 高田昌亮
    第24回日本新生児学会 1988年07月 口頭発表(一般)
  • 新生児における血漿顆粒球エラスター ゼ値の検討  [通常講演]
    田内守之, 沢田幸地, 細野茂春, 越田利弘, 小島明, 湊通嘉, 稲毛康司, 高田昌亮, 高橋滋, 大国真彦, 竹内重雄, 櫻林郁之介
    第24回日本新生児学会 1988年07月 口頭発表(一般)
  • 新生児脳障害とアミノ酸性神経伝達物質  [通常講演]
    鈴木裕, 細野茂春, 沢田幸地, 田内守之, 小平隆太郎, 金英哲, 戸田顕彦, 越田利 弘, 湊通嘉, 秋山和範, 高田昌亮, 高橋滋
    第32回未熟児新生児学会 1987年 口頭発表(一般)

MISC

  • 査読者にまなぶ 論文投稿のお作法(第10回)(最終回) 投稿論文・査読で疑問に思ったこと、対応に困ったことQ&A(その2)(Q&A)
    細野茂春 Neonatal Care 29 (10) 990 -994 2016年10月 [査読無し][招待有り]
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    香山一憲, 細野茂春 Neonatal Care 2016秋季増刊 ここからはじめる!新生児の呼吸管理ビジュアルガイド 233 -240 2016年09月 [査読無し][招待有り]
  • ここが変わったNCPRコンセンサス2015
    細野茂春 周産期学シンポジウム 34 23 -26 2016年09月 [査読無し][通常論文]
  • Nobuhiko Nagano, Tomoo Okada, Ryuta Yonezawa, Kayo Yoshikawa, Hidetoshi Fujita, Yukihiro Usukura, Masami Makimoto, Sigeharu Hosono, Yukihiko Fujita, Shigeru Takahashi, Hideo Mugishima, Tatsuo Yamamoto CLINICA CHIMICA ACTA 413 (1-2) 109 -112 2012年01月 [査読無し][通常論文]
     
    Background: Late preterm infants (LPIs; 34-37 gestational weeks at birth) have higher risk for several morbidities than do term infants (TIs). It has been suggested that a cholesterol and fatty acid supply may improve their outcomes. We investigated the lipoprotein subclass profile in LPIs to evaluate their early postnatal lipid metabolism. Methods: Eighty-one infants (25 LPIs, 56 115) were included. Cholesterol and triglyceride (TG) concentrations in 12 lipoprotein subclasses were measured at birth and at 1 month using HPLC. Results: In LPIs, the cord blood exhibited higher cholesterol concentrations in medium and large subclasses of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) compared to the values in TIs. During the first month of life, LPIs had greater increases in cholesterol concentrations of medium and large subclasses of VLDL than us, whereas postnatal increases in cholesterol concentrations of medium and large subclasses of LDL and HDL were smaller. TG concentrations were not different in each VLDL subclass at birth and at 1 month. Conclusions: In LPIs, cord blood lipoprotein subclass profiles and the early postnatal change exhibited different, especially in cholesterol concentrations. (C) 2011 Elsevier B.V. All rights reserved.

受賞

  • 2016年05月 日本大学医師会 学術奨励賞
     新生児蘇生法としての胎盤血輸血 JPN others 
    受賞者: 細野茂春

共同研究・競争的資金等の研究課題

  • 早産児における自己臍帯血輸血による新たな神経学的後障害予防戦略
    研究期間 : 2014年04月 -2017年03月 
    代表者 : 細野茂春

委員歴

  • 2014年04月   日本小児科学会   日本小児科学会雑誌編集委員会委員長
  • 2011年05月   日本産婦人科・新生児血液学会   理事
  • 2010年05月   日本小児科学会   和文誌編集委員
  • 2006年06月 - 2010年04月   日本小児科学会   和文誌編集幹事
  • 2005年06月   日本産婦人科・新生児血液学会   評議員
  • 2005年04月   日本未熟児新生児学会   評議員
  • 2005年   フォローアップ研究会   幹事
  • 2005年   慢性肺疾患研究会   幹事
  • 2004年07月   日本周産期・新生児医学会   評議員


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