研究者総覧

伊野田 悟 (イノダ サトル)

  • 眼科学講座 助教
Last Updated :2022/01/25

研究者情報

ホームページURL

科研費研究者番号

  • 60741098

J-Global ID

研究分野

  • ライフサイエンス / 眼科学

研究活動情報

論文

  • Satoru Inoda, Hidenori Takahashi, Yuji Inoue, Xue Tan, Hironobu Tampo, Yusuke Arai, Yasuo Yanagi, Hidetoshi Kawashima
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2021年10月 
    PURPOSE: To classify macular neovascularization (MNV) based on pachychoroid and drusen features and to examine the aqueous humor cytokine signatures of each group. METHODS: In total, 106 consecutive eyes with treatment-naïve MNV and 104 control eyes were examined. The aqueous humor concentrations of 15 cytokines were compared among the MNV groups classified based on the presence of drusen and/or pachychoroid features. Multidimensional scaling analysis was used to visualize the similarity level of the MNV subtypes according to their cytokine profiles. RESULTS: Thirty-one, 18, 43, and 10 eyes were classified into the pachychoroid-associated, drusen-associated, pachychoroid/drusen-associated, and non-drusen/non-pachychoroid MNV groups, respectively. Compared with the control group, cytokines were differently upregulated among the MNV groups. CRP and CXCL12 were significantly upregulated in all MNV groups, whereas CXCL13 and IL-8 were significantly upregulated in three MNV groups, excluding the non-pachychoroid/non-drusen-associated MNV group. Ang-2 was significantly upregulated in three MNV groups except the drusen-associated MNV group. PlGF was significantly upregulated in the pachychoroid-associated and drusen-associated MNV groups. CCL-2 was significantly upregulated in the pachychoroid-associated and pachychoroid/drusen-associated MNV groups. VEGF was downregulated in the pachychoroid-associated and drusen-associated MNV groups, respectively. Multidimensional scaling analysis showed a distinct cytokine profile for each MNV group. CONCLUSION: All MNV groups showed distinct cytokine profiles. Eyes with "neovascular age-related macular degeneration with drusen and concomitant pachychoroid" may share a similar etiology to those with "pachychoroid neovasculopathy" and "choroidal neovascularization with drusen," but have a distinct etiology to those without these. These findings suggest the importance of evaluating drusen and the choroid during the diagnosis of neovascular age-related macular degeneration.
  • Takahiko Hayashi, Hidenori Takahashi, Satoru Inoda, Toshiki Shimizu, Akira Kobayashi, Hidetoshi Kawashima, Takefumi Yamaguchi, Satoru Yamagami
    Scientific reports 11 1 17064 - 17064 2021年08月 
    The aim of this study was to compare aqueous humour (AqH) cytokine profiles before and after Descemet's membrane endothelial keratoplasty (DMEK) in eyes with bullous keratopathy (BK) and age-matched normal eyes. A total of 49 participants (mean age 75.0 ± 13.5 years) were divided into three groups: (1) BK patients scheduled for DMEK (BK group); (2) patients after DMEK (DMEK group; average postoperative time 1,018 ± 460 days); and (3) control participants without corneal endothelial disease scheduled for cataract surgery (control group). AqH (0.2 mL) was collected from all participants, and the levels of various AqH cytokines were simultaneously measured using a multiplex bead immunoassay. The DMEK group exhibited significantly lower concentrations of several pro-inflammatory cytokines, such as IL-1β, IL-5, IL-6, IL-10, and IL-8, and granulocyte colony stimulating factor than the BK group. In addition, the levels of IL-1β and IL-5 were significantly lower in the DMEK group than in the control group. The AqH levels of several pro-inflammatory cytokines were significantly reduced after DMEK, indicating that regeneration of the endothelial pump owing to the transplantation of a healthy endothelium might have a positive effect on anterior chamber inflammation.
  • Yusuke Arai, Hidenori Takahashi, Satoru Inoda, Shinichi Sakamoto, Xue Tan, Yuji Inoue, Satoko Tominaga, Hidetoshi Kawashima, Yasuo Yanagi
    Journal of Clinical Medicine 10 14 3162 - 3162 2021年07月 
    This study aimed to evaluate the long-term (24-month) efficacy and safety of a modified treat-and-extend (mTAE) regimen of aflibercept for macular edema (ME) due to branch retinal vein occlusion (BRVO). This was a prospective multicenter intervention study. We evaluated 50 eyes in 50 patients with ME due to BRVO enrolled between October 2016 and September 2017. The patients received intravitreal aflibercept (IVA) injections according to a mTAE regimen for 24 months. This study reports the secondary endpoints of best-corrected visual acuity (BCVA) and central subfield thickness (CST) at 24 months and compares them with previously reported primary endpoints. Compared with baseline BCVA and CST of 0.33 (0.27) and 488 (165) µm (mean (standard deviation)), respectively, BCVA and CST were significantly improved at 12 and 24 months (12 months: 0.059 (0.19) LogMAR and 299 (112) µm; 24 months: 0.034 (0.18) LogMAR and 272 (81) µm, respectively; both p < 0.0001). Over the 24-month period, the mean number of IVA injections and clinic visits was 7.4 (3.3) and 11.1 (2.0), respectively. The mTAE regimen of IVA injections for ME due to BRVO was effective for improving BCVA and reducing CST over 24 months. This regimen shows promise for reducing the number of injections and clinic visits.
  • Jo Moriya, Shinichi Sakamoto, Satoru Inoda, Hidenori Takahashi, Hidetoshi Kawashima
    Case Reports in Ophthalmology 12 1 283 - 287 2021年04月 
    Accidental intraocular lens (IOL) implantation into the corneal stroma is a rare clinical entity that can occur during the wound-assisted technique. In this report, we describe a case of an 81-year-old man who underwent cataract surgery in which the IOL was implanted into the corneal stroma with the wound-assisted technique, and we present changes in anterior segment optical coherence tomography. The IOL was removed and reinserted after widening the incision. Air tamponade was created by intracameral injection. An anterior chamber tap was performed 10 h later to reduce increased intraocular pressure. Interlayer separation of the corneal stroma was confirmed 30 min postoperatively but was corrected 4 days later. The patient’s best-corrected visual acuity (BCVA) was logMAR 0.30, and he had been diagnosed with age-related macular degeneration before surgery. Although the opacity of the corneal stroma persisted, BCVA improved to logMAR 0. When using the wound-assisted technique for IOL insertion, surgeons should take care not to implant the IOL into the corneal stroma.
  • ブロルシズマブ切替後内眼炎の投与前前房水中タンパク質濃度プロファイル
    橋本 悠人, 伊野田 悟, 高橋 秀徳, 吉田 花, 高橋 良太, 坂本 晋一, 新井 悠介, 川島 秀俊, 柳 靖雄
    日本眼科学会雑誌 125 臨増 233 - 233 (公財)日本眼科学会 2021年03月
  • ブロルシズマブ投与後内眼炎を来した滲出型加齢黄斑変性6例の背景検討
    吉田 花, 新井 悠介, 高橋 秀徳, 橋本 悠人, 譚 雪, 伊野田 悟, 高橋 良太, 藤野 雄次郎, 川島 秀俊, 柳 靖雄
    日本眼科学会雑誌 125 臨増 264 - 264 (公財)日本眼科学会 2021年03月
  • Yusuke Arai, Hidenori Takahashi, Satoru Inoda, Shinichi Sakamoto, Xue Tan, Yuji Inoue, Satoko Tominaga, Hidetoshi Kawashima, Yasuo Yanagi
    Journal of clinical medicine 9 8 2020年07月 [査読有り][通常論文]
     
    PURPOSE: To assess the efficacy and safety of a modified treat-and-extend (mTAE) regimen of aflibercept for macular edema (ME) due to branch retinal vein occlusion (BRVO). METHODS: This prospective multicentre intervention study evaluated 50 eyes of 50 patients enrolled from October 2016 to September 2017. The patients received intravitreal aflibercept (IVA) injections on an mTAE regimen for a total of 12 months. The main outcome measures were best-corrected visual acuity (BCVA) and central subfield thickness (CST) at 12 months. RESULTS: The baseline BCVA and CST were 0.33 (0.27) and 488 (171) µm (mean (standard deviation)), respectively. The BCVA and CST were significantly improved at month 12 (0.067 (0.19) LogMAR and 295 (110) µm; both p < 0.0001, paired t-test). The mean number of clinic visits and IVA injections was 6.71 (1.41) and 4.26 (0.71), respectively. The time to first recurrence from the first injection was most frequently 3 months. CONCLUSION: The mTAE regimen of IVA injections for ME due to BRVO effectively improved BCVA and reduced CST, and thus might be an effective therapy to reduce the number of injections and visits.
  • 高齢者の黄斑部新生血管の視力予後に関与する炎症性サイトカインの検討
    伊野田 悟, 高橋 秀徳, 譚 雪, 新井 悠介, 坂本 晋一, 井上 裕治, 藤野 雄次郎, 川島 秀俊, 柳 靖雄
    眼科臨床紀要 13 6 440 - 440 眼科臨床紀要会 2020年06月
  • Siamak Yousefi, Hidenori Takahashi, Takahiko Hayashi, Hironobu Tampo, Satoru Inoda, Yusuke Arai, Hitoshi Tabuchi, Penny Asbell
    The ocular surface 18 2 320 - 325 2020年04月 [査読有り][通常論文]
     
    OBJECTIVE: To apply artificial intelligence (AI) for automated identification of corneal condition and prediction of the likelihood of need for future keratoplasty intervention from optical coherence tomography (OCT)-based corneal parameters. DESIGN: Cohort study. PARTICIPANTS: We collected 12,242 corneal OCT images from 3162 subjects using CASIA OCT Imaging Systems (Tomey, Japan). We included 3318 measurements collected at the baseline visit of each patient. A total of 333 eyes had post-operative penetrating keratoplasty (PKP), lamellar keratoplasty (LKP), deep anterior keratoplasty (DALK), descemet's stripping automated endothelial keratoplasty (DSAEK) or descemet's membrane endothelial keratoplasty (DMEK) intervention. METHOD: We developed a pipeline including linear and nonlinear data transformations followed by unsupervised machine learning and applied on corneal parameters from the baseline visit of each patient. Five non-overlapping clusters of eyes were identified. Post hoc analyses revealed that clusters corresponded to different likelihoods of need for future keratoplasty. These clusters on a 2-dimensional map can be used by clinicians and surgeons to identify patients with higher risk of need for future keratoplasty intervention. MAIN OUTCOME MEASURES: The likelihood of the need for future surgery. RESULTS: The mean age of participants was 69.7 (standard deviation; SD = 16.1) and 59% were female. The normalized likelihood of need for future corneal keratoplasty intervention for eyes mapped onto clusters one to five were 2.2%, 1.0%, 33.1%, 32.7%, and 31.0%, respectively. CONCLUSIONS: The AI system can assist the (cornea) surgeon in identifying those patients who may be at higher risk for future keratoplasty using comprehensive corneal shape, thickness, and elevation parameters. Future research utilizing independent datasets is necessary to validate the proposed system.
  • 漿液性網膜剥離を伴う傾斜乳頭症候群における前房中炎症性サイトカイン濃度
    井上 裕治, 高橋 秀徳, 林 あゆみ, 長岡 広祐, 高橋 良太, 伊野田 悟, 坂本 晋一, 新井 悠介, 富永 聡子, 譚 雪, 川島 秀俊, 柳 靖雄
    日本眼科学会雑誌 124 臨増 167 - 167 (公財)日本眼科学会 2020年03月
  • Takahiko Hayashi, Hitoshi Tabuchi, Hiroki Masumoto, Shoji Morita, Itaru Oyakawa, Satoru Inoda, Naoko Kato, Hidenori Takahashi
    Eye & contact lens 46 2 121 - 126 2020年03月 [査読有り][通常論文]
     
    PURPOSE: To evaluate the efficacy of deep learning in judging the need for rebubbling after Descemet's endothelial membrane keratoplasty (DMEK). METHODS: This retrospective study included eyes that underwent rebubbling after DMEK (rebubbling group: RB group) and the same number of eyes that did not require rebubbling (non-RB group), based on medical records. To classify the RB group, randomly selected images from anterior segment optical coherence tomography at postoperative day 5 were evaluated by corneal specialists. The criterion for rebubbling was the condition where graft detachment reached the central 4.0-mm pupil area. We trained nine types of deep neural network structures (VGG16, VGG19, ResNet50, InceptionV3, InceptionResNetV2, Xception, DenseNet121, DenseNet169, and DenseNet201) and built nine models. Using each model, we tested the validation data and evaluated the model. RESULTS: This study included 496 images (31 eyes from 24 patients) in the RB group and 496 images (31 eyes from 29 patients) in the non-RB group. Because 16 picture images were obtained from the same point of each eye, a total of 992 images were obtained. The VGG19 model was found to have the highest area under the receiver operating characteristic curve (AUC) of all models. The AUC, sensitivity, and specificity of the VGG19 model were 0.964, 0.967, and 0.915, respectively, whereas those of the best ensemble model were 0.956, 0.913, and 0.921, respectively. CONCLUSIONS: This automated system that enables the physician to be aware of the requirement of RB might be clinically useful.
  • Satoru Inoda, Takahiko Hayashi, Hidenori Takahashi, Itaru Oyakawa, Hideaki Yokogawa, Akira Kobayashi, Naoko Kato, Hidetoshi Kawashima
    PloS one 15 6 e0234202  2020年 [査読有り][通常論文]
     
    PURPOSE: To investigate the factors associated with endothelial survival after Descemet's membrane endothelial keratoplasty (DMEK) in eyes of Asian patients with bullous keratopathy (BK). METHODS: In this retrospective, consecutive interventional case series, 72 eyes of 72 patients who underwent DMEK were evaluated. Best corrected visual acuity (BCVA) and corneal endothelial cell density (ECD) were assessed at 12 months postoperatively. Multiple regression analysis was performed to assess parameters such as age, sex, axial length, preoperative visual acuity, re-bubbling, the ratio of graft to cornea area, iris damage scores, types of filling gases, air or SF6 volume in the anterior chamber (AC) on postoperative day 1, and ECD loss rates at 12 months postoperatively. RESULTS: BCVA improved significantly at 12 months after DMEK (P < .001). The rate of ECD loss at 12 months after DMEK was 54.4 ± 16.1%. Multiple linear regression analysis showed that a larger ratio of graft to corneal area (P = 0.0061) and higher donor ECD (P = 0.042) were the primary factors for a lower ECD loss rate at 12 months after DMEK. CONCLUSION: A relatively larger graft size compared to the host cornea and more donor ECD might help endothelial survival in patients with BK. Moreover, for such patients, the surgeon should attempt to use a relatively larger graft size when performing DMEK, particularly in Asian eyes.
  • Yusuke Arai, Hidenori Takahashi, Satoru Inoda, Xue Tan, Shinichi Sakamoto, Yuji Inoue, Yujiro Fujino, Hidetoshi Kawashima, Yasuo Yanagi
    PloS one 15 3 e0229342  2020年 [査読有り][通常論文]
     
    We aimed to construct a better model for predicting treatment outcomes of anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration (nAMD) using the concentrations of aqueous humour proteins at baseline and during treatment. From the data of 48 treatment-naïve nAMD eyes that received intravitreal ranibizumab pro re nata for up to 12 months, we used the aqueous humour concentrations of C-X-C motif chemokine ligand 1 (CXCL1), CXCL12, CXCL13, interferon-γ-induced protein 10, monocyte chemoattractant protein 1 (MCP-1), C-C motif chemokine ligand 11, interleukin 6 (IL-6), IL-10, and matrix metalloproteinase 9 (MMP-9). After stepwise regression, multivariate analysis was performed to identify which predictors were significantly associated with best-corrected visual acuity (BCVA) changes and the number of injections. The results demonstrated that besides male sex (β coefficient = -0.088, P = 0.040) and central retinal thickness (β coefficient = 0.00051 per μm, P = 0.027), MCP-1 (β coefficient = 0.44, P < 0.001) and IL-10 (β coefficient = -0.16, P = 0.033) were significantly correlated with baseline BCVA. Additionally, high MCP-1 at baseline (β coefficient = -0.20, P = 0.015) and low CXCL13 at baseline (β coefficient = 0.10, P = 0.0054) were independently associated with better BCVA change at 12 months. High MMP-9 at the first injection (β coefficient = 0.56, P = 0.01), CXCL12 at the third injection (β coefficient = 0.10, P = 0.0002), and IL-10 at the third injection (β coefficient = 1.3, P = 0.001) were predictor variables associated with the increased number of injections. In conclusion, aqueous humour protein concentrations may have predictive abilities of BCVA change over 12 months and the number of injections in pro re nata treatment of exudative nAMD.
  • Satoru Inoda, Takahiko Hayashi, Hidenori Takahashi, Itaru Oyakawa, Hideaki Yokogawa, Akira Kobayashi, Naoko Kato, Hidetoshi Kawashima
    Cornea 38 12 e58-e59  2019年12月 [査読有り][通常論文]
  • Ichiya Sano, Hidenori Takahashi, Satoru Inoda, Shinichi Sakamoto, Yusuke Arai, Yuji Takahashi, Akira Ohkubo, Hidetoshi Kawashima, Chihiro Mayama
    American journal of ophthalmology 206 11 - 16 2019年10月 [査読有り][通常論文]
     
    PURPOSE: To investigate changes in the interpupillary distance (IPD) after continual instillation of topical prostaglandin analogs (PGAs) in glaucoma patients as an objective indicator of prostaglandin-associated periorbitopathy (PAP). DESIGN: Retrospective, comparative case series. METHODS: A total of 152 institutional patients with glaucoma were enrolled in this study. Inclusion criteria were visual acuities exceeding 10/20 bilaterally and no intraocular surgery during observation. Intervention/observation procedures: First-time bilateral instillation of bimatoprost, travoprost, latanoprost, or tafluprost and IPDs measured by automatic refractometry. IPDs, intraocular pressures (IOPs), and refractive errors were measured before and after continual drug administration (treatment, 2-24 months). MAIN OUTCOME MEASUREMENTS: Post-treatment changes in IPDs. A total of 61 untreated patients served as controls. RESULTS: The IPDs shortened significantly (P < 0.001) after treatment (-0.80 ± 2.1 mm); the IPDs of control subjects remained unchanged (0.05 ± 0.96 mm; P = 0.69). The IPD change after bimatoprost instillation (-2.20 ± 0.97 mm) was significantly (P < 0.001) greater than with other PGAs (-0.65 ± 2.09 mm). The IOPs decreased significantly (P < 0.001) (-3.7 ± 4.3 mm Hg); the refractive errors did not change significantly (P < 0.099) (-0.07 ± 0.69 diopter) post-treatment. The percentages of subjects with 2-mm or greater decreases in IPD after bimatoprost, travoprost, latanoprost, or tafluprost were 85.7%, 20.0%, 18.2%, and 17.2%, respectively, and with 3-mm or greater decreases in IPD 35.7%, 12.0%, 14.5%, and 12.1%, respectively. The specificities were 93.4% and 100% in the control group, respectively, with IPD threshold changes of 2 and 3 mm or more, respectively. CONCLUSIONS: The IPD decreased significantly after topical PGAs within 24 months. The effect was significantly greater with bimatoprost than with other PGAs. The noninvasive, immediate automatic refractometry measurement may be an objective numerical indicator of PAP.
  • Satoru Inoda, Takahiko Hayashi, Hidenori Takahashi, Itaru Oyakawa, Hideaki Yokogawa, Akira Kobayashi, Naoko Kato, Hidetoshi Kawashima
    Cornea 38 7 820 - 824 2019年07月 [査読有り][通常論文]
     
    PURPOSE: To investigate factors associated with cystoid macular edema (CME) after Descemet membrane endothelial keratoplasty (DMEK) in Asian eyes. METHODS: In this retrospective, interventional, consecutive case series, 77 eyes of 65 patients who underwent DMEK were evaluated; in 53 eyes, cataract surgery was performed 1 month before DMEK (staged DMEK), and 24 eyes underwent DMEK alone (simple DMEK). Central retinal thickness, incidence of CME, postoperative best-corrected visual acuity, central corneal thickness, and corneal endothelial cell density were assessed at 1, 3, and 6 months after surgery. Multiple regression analysis and stepwise variable selection were performed for parameters such as type of surgery, iris damage scores, age, sex, axial length, preoperative visual acuity, rebubbling, air volume in the anterior chamber on postoperative day 1, history of diabetes, and endothelial cell density loss rates at 6 months after surgery. RESULTS: CME occurred in 12 (15.6%) of 77 eyes. There was no significant difference in best-corrected visual acuity between eyes with and without CME (P = 0.27). Multivariable analysis revealed that the difference in iris damage scores between before and after DMEK (P < 0.001), air volume in the anterior chamber (P = 0.012), simple DMEK (P = 0.020), and rebubbling (P = 0.036) were significantly associated with CME. Stepwise variable selection indicated that iris damage (P < 0.001) was the most important risk factor for CME. CONCLUSIONS: Iris damage due to DMEK might be a possible risk and aggravating factor for the development of CME after DMEK. Surgeons should attempt to minimize damage to the iris.
  • Nagaoka K, Inoda S, Takahashi H, Arai Y, Inoue Y, Takizawa Y, Fujioka S, Kawashima H
    Case Rep Ophthalmol 10 195 - 199 2019年06月 [査読有り][通常論文]
  • Satoru Inoda, Hidenori Takahashi, Yuji Inoue, Hironobu Tampo, Shinichi Sakamoto, Yusuke Arai, Hidetoshi Kawashima, Yasuo Yanagi
    Clinical ophthalmology (Auckland, N.Z.) 13 959 - 968 2019年 [査読有り][通常論文]
     
    Purpose: To investigate the efficacy of half-dose photodynamic therapy (PDT) for treating symptomatic serous non-neovascular pigment epithelial detachment (PED) and to identify factors associated with treatment outcome. Patients and methods: This is a single-institute retrospective case series involving 12 eyes of 12 consecutive patients with serous non-neovascular PED who received half-dose PDT. We investigated the temporal change in best-corrected visual acuity (BCVA), the anatomic outcomes of PED, including recurrence, central choroidal thickness (CCT), and also choroidal thickness as a possible factor associated with treatment outcome. Results: At baseline, mean logMAR BCVA was 0.06 (range Snellen equivalent 6/20 to 24/20); 24 months later, it was 0.01 (Snellen equivalent 6/20 to 24/20; P=0.3). At 3 months, PED had completely flattened in 8, decreased in height in 2, and remained unchanged in 2. The CCT in eyes with PED was 410 µm and thicker than that in fellow eyes (290 µm, P<0.0001). Recurrence was noted in 2 within 12 months after treatment. Eyes in which the choroidal thickness with a baseline CCT >350μm or a 100 µm difference in CCT responded favorably to half-dose PDT (P=0.02). Conclusion: Half-dose PDT is effective in patients with non-neovascular PED. Thicker choroid and some difference in CCT between affected and fellow eye might be a good index for predicting the efficacy of this treatment.
  • Takayuki Fusumae, Koji Kamiya, Takeo Maekawa, Mayumi Komine, Satoru Murata, Satoru Inoda, Ryota Takahashi, Hidetoshi Kawashima, Mamitaro Ohtsuki
    The Journal of dermatology 45 6 e159-e160  2018年06月 [査読有り][通常論文]
  • Hidenori Takahashi, Yuji Inoue, Xue Tan, Satoru Inoda, Shinichi Sakamoto, Yusuke Arai, Yasuo Yanagi, Yujiro Fujino, Hidetoshi Kawashima
    Clinical ophthalmology (Auckland, N.Z.) 12 369 - 375 2018年 [査読有り][通常論文]
     
    Purpose: To investigate the correlation between visual acuity and central macular thickness (CMT) and choroidal thickness (CCT) in patients with wet age-related macular degeneration (AMD). Methods: In this retrospective analysis, 14 eyes that received >10 ranibizumab injections (based on pro re nata [PRN] regimen) and maintained initial visual acuity gain were analyzed. The following 5 parameters were measured at the foveal center: CMT (distance from the inner limiting membrane [ILM] to Bruch's membrane); central retinal thickness (CRT; distance from the ILM to the inner limit of the retinal pigment epithelium or subretinal fluid [SRF]); SRF thickness (SRFT); pigment epithelium detachment thickness (PEDT); and CCT. The correlation between the logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) and the 5 parameters was examined with generalized estimating equations. Results: CMT, CRT, and CCT were negatively correlated with logMAR BCVA (P=0.031, 0.023, and 0.036, respectively) when only CMT values less than the thickness that maximized visual acuity for each eye were used for the analysis. Each 100-μm reduction in CMT, CRT, or CCT improved logMAR BCVA by -0.1, -0.08, or -0.07, respectively. SRFT and PEDT were not correlated with BCVA. The median CMT that maximized the visual acuity was 230 μm. Conclusion: Dry macula with CMT <230 μm was associated with temporary decrease in visual acuity in AMD patients whose visual acuity was maintained with PRN regimen.
  • Shinichi Sakamoto, Hidenori Takahashi, Yuji Inoue, Yusuke Arai, Satoru Inoda, Natsuko Kakinuma, Yujiro Fujino, Tatsuro Tanabe, Hidetoshi Kawashima, Yasuo Yanagi
    Clinical ophthalmology (Auckland, N.Z.) 12 1137 - 1147 2018年 [査読有り][通常論文]
     
    Purpose: We report the 2-year outcomes of intravitreal aflibercept (IVA) for exudative age-related macular degeneration (AMD) with good visual acuity (VA) and examine the baseline factors associated with good visual outcome. Materials and methods: This multicenter, prospective study evaluated 39 eyes (39 AMD patients) enrolled from August 2013 to August 2014 at 12 and 24 months. Only patients with initial best-corrected VA (BCVA) >0.3 logarithm of the minimum angle of resolution (20/40 Snellen) were eligible. Three consecutive monthly IVA injections were followed by 2 monthly injections for 12 months. Thereafter, patients received injections on a treat- and-extend regimen for up to 24 months. Outcome measures included BCVA and central macular thickness (CMT) at 12 and 24 months. Post hoc analysis, BCVA, and CMT were evaluated by AMD types (typical AMD [tAMD], type 1, and type 2 polypoidal choroidal vasculopathy [PCV]). Baseline characteristics and BCVA associations were evaluated with linear regression analysis and Student's t-test. Results: Mean age was 69 years and 26 of 39 eyes were male. tAMD, type 1 and type 2 PCV occurred in 18, 12, and 9 eyes, respectively. Baseline mean BCVA was 0.097 logarithm of the minimum angle of resolution (20/25 Snellen) and showed significant improvement to 0.058 (20/22 Snellen, P=0.03) at 12 months and 0.066 (20/23) at 24 months. CMT improved significantly from 320 (99) µm (mean [SD]) to 250 (93) µm (P=0.002) at 12 months and 240 (93) µm (P=0.0005) at 24 months. BCVA and CMT were not significantly different among the three groups. Only subretinal hemorrhage (SRH) was significantly associated with improved BCVA. BCVA change from baseline was -0.12 with SRH and -0.011 without SRH (P=0.017) at 12 months. Conclusion: IVA showed good efficacy for exudative AMD with good VA at 24 months. tAMD and type 1 and 2 PCV showed similar prognosis. Baseline SRH predicted favorable long-term vision in AMD with good VA.
  • Siamak Yousefi, Ebrahim Yousefi, Hidenori Takahashi, Takahiko Hayashi, Hironobu Tampo, Satoru Inoda, Yusuke Arai, Penny Asbell
    PloS one 13 11 e0205998  2018年 [査読有り][通常論文]
     
    We developed an unsupervised machine learning algorithm and applied it to big corneal parameters to identify and monitor keratoconus stages. A big dataset of corneal swept source optical coherence tomography (OCT) images of 12,242 eyes acquired from SS-1000 CASIA OCT Imaging Systems in multiple centers across Japan was assembled. A total of 3,156 eyes with valid Ectasia Status Index (ESI) between zero and 100% were selected for the downstream analysis. Four hundred and twenty corneal topography, elevation, and pachymetry parameters (excluding ESI Keratoconus indices) were selected. The algorithm included three major steps. 1) Principal component analysis (PCA) was used to linearly reduce the dimensionality of the input data from 420 to eight significant principal components. 2) Manifold learning was used to further reducing the selected principal components nonlinearly to two eigen-parameters. 3) Finally, a density-based clustering was applied to the eigen-parameters to identify eyes with keratoconus. Visualization of clusters in 2-D space was used to validate the quality of learning subjectively and ESI was used to assess the accuracy of the identified clusters objectively. The proposed method identified four clusters; I: a cluster composed of mostly normal eyes (224 eyes with ESI equal to zero, 23 eyes with ESI between five and 29, and nine eyes with ESI greater than 29), II: a cluster composed of mostly healthy eyes and eyes with forme fruste keratoconus (1772 eyes with ESI equal to zero, 698 eyes with ESI between five and 29, and 117 eyes with ESI greater than 29), III: a cluster composed of mostly eyes with mild keratoconus stage (184 eyes with ESI greater than 29, 74 eyes with ESI between five and 29, and 6 eyes with ESI equal to zero), and IV: a cluster composed of eyes with mostly advanced keratoconus stage (80 eyes had ESI greater than 29 and 1 eye had ESI between five and 29). We found that keratoconus status and severity can be well identified using unsupervised machine learning algorithms along with linear and non-linear corneal data transformation. The proposed method can better identify and visualize the keratoconus stages.
  • Ryota Takahashi, Atsushi Yoshida, Satoru Inoda, Akira Okubo, Hidetoshi Kawashima
    Clinical ophthalmology (Auckland, N.Z.) 11 1151 - 1156 2017年 [査読有り][通常論文]
     
    PURPOSE: To investigate uveitis incidence of new patients who visited Jichi Medical University Hospital, Tochigi, north of Tokyo, during 2011-2015, and to compare the results with previously reported data from other facilities. METHODS: We retrospectively analyzed clinical records of new patients with uveitis from April 2011 to March 2015 and compared the uveitis incidence with those from other hospitals. RESULTS: A total of 502 patients were enrolled in the study; definite diagnoses were made in 262 patients (52.2%). The top 4 diseases were sarcoidosis, 47 patients (9.4%); Vogt-Koyanagi-Harada (VKH) disease, 35 patients (7.0%); herpetic iritis, 29 patients (5.8%); and Behçet's disease, 21 patients (4.2%). CONCLUSION: The most commonly diagnosed diseases in our study were sarcoidosis, VKH disease, herpetic iritis, and Behçet's disease. Compared with the latest nationwide survey in Japan, our results showed similar trends.
  • Satoru Inoda, Yukihiro Sato, Yusuke Arai, Hiroto Obata, Jun Suzuki, Toshikatsu Kaburaki, Katsuhiko Kamei
    Nippon Ganka Gakkai zasshi 119 9 632 - 9 2015年09月 [査読有り][通常論文]
     
    BACKGROUND: We report a case with bilateral endogenous fungal subretinal abscesses. To our knowledge, this is the first report from Japan in which Scedosporium prolificans (S. prolificans) was cultured from intraocular tissue. CASE: A 74-year-old man, receiving chemotherapy for acute myeloid leukemia, complained of visual loss in both eyes. Best-corrected visual acuity was hand motion in the right and 2/200 in the left eye. His right eye showed exophthalmos, inflammation in the anterior chamber and iris neovascularization. Funduscopy revealed no details as there was vitreous opacity in the right eye, and irregular round yellowish-white subretinal lesions involving the macula in the left eye. Blood culture was negative, and C-reactive protein (CRP) and β-D glucan titers were high. An antifungal drug and broad-spectrum antibiotics were initiated. Two days after the initial visit, right visual acuity had deteriorated to light perception. Enucleation of the right eye was performed for diagnosis and treatment. Fungi were cultured from the subretinal lesion, confirming a diagnosis of S. prolificans infection. After systemic administration and intravitreal injections of antifungal agents, the subretinal abscess in the left eye gradually diminished. At present, six months after the first visit, left visual acuity is 20/200. CONCLUSION: Although S. prolificans endophthalmitis can be intractable, this case suggests that repeated intravitreal antifungal agent injections can be effective.

MISC

  • 伊野田 悟, 高橋 秀徳 あたらしい眼科 37 (1) 61 -62 2020年01月 [査読無し][通常論文]
     
    人工知能(AI)による画像解析の報告は日々増加している。光干渉断層計画像解析は広く行われ、加齢黄斑変性での漿液性網膜剥離の同定も可能となってきている。また、他科でもその高い画像解析能力を応用した臨床応用が試みられている。本稿ではAIの治療適応への応用について述べる。(著者抄録)
  • 若年者の増殖糖尿病網膜症に対する硝子体手術成績
    案浦 加奈子, 新井 悠介, 伊野田 悟, 坂本 晋一, 佐野 一矢, 井上 裕治, 高橋 秀徳, 川島 秀俊 眼科臨床紀要 12 (11) 840 -840 2019年11月 [査読無し][通常論文]
  • 近藤 由佳, 新井 悠介, 高橋 秀徳, 坂本 晋一, 伊野田 悟, 佐野 一矢, 井上 裕治, 川島 秀俊 臨床眼科 73 (8) 1039 -1044 2019年08月 [査読無し][通常論文]
     
    <文献概要>目的:網膜静脈分枝閉塞症(BRVO)発症後の硝子体出血に対し硝子体手術を行った症例から,手術成績と網膜光凝固(PC)の必要性について検討した。対象と方法:対象は2013年4月〜2018年3月に自治医科大学眼科でBRVO発症後に硝子体出血を生じた眼に対し硝子体手術を施行した46例46眼。術前PCの有無,術前・術後視力,術後視力と術前PCの有無,無血管野の部位と術後視力,術中・術後合併症について後ろ向きに検討した。結果:硝子体手術前に31例(67%)でPCが施行されていた。術後視力1.0以上は29例(63%)で得られた。術前PCの有無と術後視力との間には関連はなく,網膜血管アーケード内に無血管野があるものでは術後視力が不良であった。術中・術後合併症は10例にみられた。結論:術前にPCが施行された症例が多かったが,術後視力は良好であった。術前PCの有無は術後視力に影響はなかった。PCの必要性についてはさらに検討が必要と考えられた。
  • 自治医大における網膜静脈分枝閉塞症に伴う硝子体出血に対する硝子体手術の検討
    近藤 由佳, 新井 悠介, 高橋 秀徳, 坂本 晋一, 伊野田 悟, 佐野 一矢, 井上 裕治, 川島 秀俊 眼科臨床紀要 12 (4) 341 -341 2019年04月 [査読無し][通常論文]
  • 滲出型加齢黄斑変性のアフリベルセプトtreat and extend療法における毎月投与症例と3ヵ月延長例の眼内サイトカインの違い
    福与 波音, 高橋 秀徳, 坂本 晋一, 新井 悠介, 伊野田 悟, 高橋 良太, 井上 裕治, 川島 秀俊 眼科臨床紀要 12 (4) 341 -341 2019年04月 [査読無し][通常論文]
  • 当院における角膜移植手術の現状
    伊野田 悟, 高橋 秀徳, 林 孝彦, 川島 秀俊 眼科臨床紀要 12 (4) 342 -342 2019年04月 [査読無し][通常論文]
  • 伊野田 悟, 高橋 秀徳 あたらしい眼科 36 (4) 441 -447 2019年04月 [査読無し][通常論文]
  • DMEK術後移植片剥離に対する空気再注入の人工知能深層学習判定システムの構築
    林 孝彦, 田淵 仁志, 升本 浩紀, 森田 翔治, 親川 格, 加藤 直子, 伊野田 悟, 高橋 秀徳 日本眼科学会雑誌 123 (臨増) 199 -199 2019年03月 [査読無し][通常論文]
  • 深層学習による光干渉断層計像からの最高矯正視力推測
    伊野田 悟, 高橋 秀徳, 新井 悠介, 反保 宏信, 坂本 晋一, 松井 良諭, 川島 秀俊, 柳 靖雄 日本眼科学会雑誌 123 (臨増) 291 -291 2019年03月 [査読無し][通常論文]
  • 伊野田 悟, 高橋 秀徳 OCULISTA (69) 17 -25 2018年12月 [査読無し][通常論文]
     
    2018年4月11日、米国食品医薬品局が深層学習による人工知能を医療機器として初めて販売許可した。米国ではプライマリ・ケア施設でスクリーニングが行われ、本人工知能はそのスクリーニングのための人工知能であり「軽症非増殖糖尿病網膜症以下なので1年後再撮影」または「中等症非増殖糖尿病網膜症以上だから眼科医に紹介」のどちらかを指示する。基本的な技術は畳み込みニューラルネットワークと深層学習であり、それらが近年の一般画像識別の自動化をもたらした。これらの人工知能は画像の特徴点を自動で抽出できるため、ビッグデータで学習をすればヒトより高い識別率を獲得できる。現在糖尿病網膜症の検出・病期分類の人工知能が多数論文報告されている。(著者抄録)
  • 網膜色素上皮剥離から中心性漿液性脈絡網膜症に移行した2例
    恩田 昌紀, 井上 裕治, 伊野田 悟, 坂本 晋一, 新井 悠介, 高橋 秀徳, 川島 秀俊 眼科臨床紀要 11 (11) 833 -833 2018年11月 [査読無し][通常論文]
  • 視力良好な加齢黄斑変性に対するアフリベルセプトの視力維持の条件検討
    伊野田 悟, 高橋 秀徳, 新井 悠介, 坂本 晋一, 井上 裕治, 藤野 雄次郎, 川島 秀俊, 柳 靖雄 眼科臨床紀要 11 (9) 708 -708 2018年09月 [査読無し][通常論文]
  • 滲出型加齢黄斑変性におけるpachyvessel所見の有無と炎症性サイトカインの関連
    恩田 昌紀, 高橋 秀徳, 井上 裕治, 譚 雪, 新井 悠介, 高橋 良太, 伊野田 悟, 坂本 晋一, 佐野 一矢, 藤野 雄次郎, 川島 秀俊, 柳 靖雄 眼科臨床紀要 11 (9) 718 -718 2018年09月 [査読無し][通常論文]
  • 網脈絡膜萎縮発症時に脈絡膜肥厚と脈絡膜から色素上皮上への滲出が観察された1例
    粕谷 友香, 新井 悠介, 高橋 秀徳, 伊野田 悟, 坂本 晋一, 井上 裕治, 川島 秀俊, 柳 靖雄 眼科臨床紀要 11 (5) 402 -402 2018年05月 [査読無し][通常論文]
  • 巨大網膜色素上皮剥離破裂時に巨大黄斑円孔を来した1例
    長岡 広祐, 新井 悠介, 伊野田 悟, 高橋 秀徳, 井上 裕治, 滝澤 裕一, 藤岡 伸欣, 川島 秀俊 眼科臨床紀要 11 (5) 402 -402 2018年05月 [査読無し][通常論文]
  • 滲出型加齢黄斑変性におけるpachyvessel所見の有無と炎症性サイトカインの関連
    恩田 昌紀, 高橋 秀徳, 井上 裕治, 譚 雪, 新井 悠介, 高橋 良太, 伊野田 悟, 坂本 晋一, 佐野 一矢, 藤野 雄次郎, 川島 秀俊, 柳 靖雄 日本眼科学会雑誌 122 (臨増) 177 -177 2018年03月 [査読無し][通常論文]
  • 加齢黄斑変性における脈絡膜透過性亢進の有無による光線力学療法への反応性の検討
    長岡 広祐, 高橋 良太, 添田 めぐみ, 伊野田 悟, 坂本 晋一, 新井 悠介, 井上 裕治, 高橋 秀徳, 川島 秀俊 日本眼科学会雑誌 122 (臨増) 201 -201 2018年03月 [査読無し][通常論文]
  • 深層学習によるカラー眼底写真からの脈絡膜厚推測 多施設での妥当性検討
    新井 悠介, 高橋 秀徳, 山下 高明, 長谷川 哲也, 大上 智弘, 園田 祥三, 田中 克明, 反保 宏信, 伊野田 悟, 坂本 晋一, 梯 彰弘, 川島 秀俊, 柳 靖雄 日本眼科学会雑誌 122 (臨増) 235 -235 2018年03月 [査読無し][通常論文]
  • 深層学習によるカラー眼底写真からの脈絡膜厚推測
    反保 宏信, 高橋 秀徳, 添田 めぐみ, 高橋 良太, 伊野田 悟, 坂本 晋一, 新井 悠介, 井上 裕治, 川島 秀俊, 柳 靖雄 眼科臨床紀要 10 (10) 873 -873 2017年10月 [査読無し][通常論文]
  • BRAF阻害薬ベムラフェニブ使用中にVogt-小柳-原田病を発症した1例
    伊野田 悟, 吉田 淳, 高橋 良太, 伏間江 貴之, 大槻 マミ太郎, 川島 秀俊 眼科臨床紀要 10 (10) 873 -873 2017年10月 [査読無し][通常論文]
  • 高橋 良太, 伊野田 悟, 吉田 淳, 森本 哲, 川島 秀俊 あたらしい眼科 34 (5) 718 -721 2017年05月 [査読無し][通常論文]
     
    当初不全型Behcet病と診断された11歳の女児にコルヒチン治療を開始したが、有害事象によって治療継続が困難であったため、低用量副腎皮質ステロイド薬に切り替えた。その5ヵ月後、両眼にぶどう膜炎を発症し完全型Behcet病と診断した。コルヒチン治療に不耐、HLA-A26陽性などを総合的かつ慎重に検討し、インフリキシマブ治療を導入した。導入後、主症状4症状と副症状(股関節痛)は改善し、その後再燃を認めていない。小児Behcet病ぶどう膜炎に対するインフリキシマブ治療の報告は少ないが、非常に有効な治療と考えられ、さらなる臨床経験の蓄積が期待される。(著者抄録)
  • 深層学習によるカラー眼底写真からの脈絡膜厚推測
    反保 宏信, 高橋 秀徳, 添田 めぐみ, 高橋 良太, 伊野田 悟, 坂本 晋一, 新井 悠介, 井上 裕次, 川島 秀俊, 柳 靖雄 日本眼科学会雑誌 121 (臨増) 213 -213 2017年03月 [査読無し][通常論文]
  • 漿液性色素上皮剥離に対するベルテポルフィン光線力学療法の治療成績
    伊野田 悟, 反保 宏信, 高橋 秀徳, 井上 裕治, 佐藤 彩, 竹澤 美貴子, 川島 秀俊 眼科臨床紀要 9 (10) 868 -868 2016年10月 [査読無し][通常論文]
  • 11歳でインフリキシマブ導入となった完全型ベーチェット病患者の1例
    高橋 良太, 吉田 淳, 伊野田 悟, 森本 哲, 川島 秀俊 眼科臨床紀要 9 (5) 465 -465 2016年05月 [査読無し][通常論文]
  • Scedosporium prolificansによる両眼の内因性網膜下膿瘍の1例
    伊野田 悟, 佐藤 幸裕, 新井 悠介, 小幡 博人, 鈴木 潤 眼科臨床紀要 8 (11) 853 -853 2015年11月 [査読無し][通常論文]
  • 伊野田 悟, 佐藤 幸裕, 新井 悠介, 小幡 博人, 鈴木 潤, 蕪城 俊克, 亀井 克彦 日本眼科学会雑誌 119 (9) 632 -639 2015年09月 [査読無し][通常論文]
     
    背景:両眼の内因性真菌性網膜下膿瘍を発症し,眼球内容物から,検索し得た範囲では本邦初のScedosporium prolificans(S.prolificans)が分離された症例を経験した.症例:74歳男性.急性骨髄性白血病の治療中に両眼の視力低下を自覚.眼科検査にて,矯正視力は右手動弁,左0.01.右眼は眼球突出,前房内炎症と虹彩新生血管があり,眼底は透見不能であった.左眼は黄斑を含む黄白色・不整円形の網膜下病巣を認めた.血液培養は陰性,C-reactive protein(CRP)とβ-Dグルカンの高値を認め,抗真菌薬と広域抗菌薬を全身投与した.右眼は初診2日後に光覚弁となり,診断を兼ねて眼球摘出した.網膜下病巣より真菌が培養され,S.prolificansと同定された.抗真菌薬の全身投与と,計16回の硝子体内注射で膿瘍は徐々に縮小した.初診から6か月目の左眼・矯正視力は0.1である.結論:S.prolificans眼内炎は難治とされているが,反復した抗真菌薬の硝子体内注射の併用が有効と考えられた.(著者抄録)
  • Satoru Inoda, Hidenori Takahashi, Xue Tan, Natsuko Kakinuma, Yoko Nomura, Shin-ichi Sakamoto, Yusuke Arai, Yujiro Fujino, Hidetoshi Kawashima, Yasuo Yanagi INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 56 (7) 2015年06月 [査読無し][通常論文]
  • 伊野田 悟, 吉田 淳, 川島 秀俊 臨床眼科 69 (6) 869 -873 2015年06月 [査読無し][通常論文]
     
    目的:抗好中球細胞質抗体(ANCA)関連血管炎に視神経障害が発症したと推定される1症例の報告。症例:74歳女性が右眼視力の低下で受診した。以前からぶどう膜炎が両眼にあり,プレドニゾロンを内服していた。右眼に白内障手術と難聴の既往があった。所見:矯正視力は右0.1,左1.2で,眼圧は右5mmHg,左16mmHgであった。右眼に前房の炎症所見と硝子体混濁があった。蛍光眼底造影で後部ぶどう膜炎の所見があった。左眼には病的所見はなかった。MPO-ANCAが高値で,難聴の既往と合わせ,内科でANCA関連血管炎と診断された。プレドニゾロン内服を継続した。5ヵ月後に左眼視力が低下し,その3週間後に受診した。矯正視力は右0.3,左0であり,蛍光眼底造影で左眼乳頭の低蛍光があった。ANCA関連血管炎に関連した後部虚血性視神経症が推定された。左眼視力は回復しなかった。結論:ANCA関連血管炎に関連した視神経症は,多彩で難治性であることを本症例は示している。(著者抄録)
  • Scedosporium prolificansによる両眼の内因性網膜下膿瘍の1例
    伊野田 悟, 佐藤 幸裕, 新井 悠介, 小幡 博人, 鈴木 潤 眼科臨床紀要 8 (4) 265 -265 2015年04月 [査読無し][通常論文]
  • 網膜静脈閉塞症慢性期における前房中炎症性サイトカイン濃度
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共同研究・競争的資金等の研究課題

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