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市原 佐保子 イチハラ サホコ

所属部署名環境予防医学講座
職名教授ホームページURLhttp://www.jichi.ac.jp/enviro/hp/index.html

プロフィール

研究キーワード

    環境医学, 産業医学, 循環器病学, 心毒性学

研究分野

  • 社会医学 / 衛生学
  • 内科系臨床医学 / 循環器内科学

学歴

  • -
    2001年03月
    名古屋大学大学院 医学研究科(日本)
  • 1984年03月
    -
    1990年04月
    名古屋大学 医学部 医学科(日本)

所属学協会

  • 日本衛生学会
  • 日本産業衛生学会
  • 日本毒性学会
  • 日本循環器学会
  • 日本内科学会
  • 日本人類遺伝学会
所属学協会を全て表示する
所属学協会閉じる
  • 日本衛生学会
  • 日本産業衛生学会
  • 日本毒性学会
  • 日本循環器学会
  • 日本内科学会
  • 日本人類遺伝学会

学位

  • 医学博士

研究活動

論文

  • NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.
    Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K
    Molecular medicine reports 2018年10月
  • Proteomic Profiling of Exosomal Proteins for Blood-based Biomarkers in Parkinson's Disease.
    Kitamura Y, Kojima M, Kurosawa T, Sasaki R, Ichihara S, Hiraku Y, Tomimoto H, Murata M, Oikawa S
    Neuroscience 392 121-128 2018年09月
  • Pulmonary hypofunction due to calcium carbonate nanomaterial exposure in occupational workers: a cross-sectional study.
    Li G, Liang L, Yang J, Zeng L, Xie Z, Zhong Y, Ruan X, Dong M, Yang Z, Lai G, Huang W, Yang A, Chen J, Wu B, Xu H, Meng D, Hu S, Xia L, Yang X, Li L, Ichihara S, Ichihara G, Huang H, Huang Z
    Nanotoxicology 12(6) 571-585 2018年08月
  • Exposure of Mice to 1,2-Dichloropropane Induces CYP450-Dependent Proliferation and Apoptosis of Cholangiocytes.
    Zhang X, Zong C, Zhang L, Garner E, Sugie S, Huang C, Wu W, Chang J, Sakurai T, Kato M, Ichihara S, Kumagai S, Ichihara G
    Toxicological sciences : an official journal of the Society of Toxicology 162(2) 559-569 2018年04月
  • MicroRNAs as Potential Mediators for Cigarette Smoking Induced Atherosclerosis.
    Yokoyama Y, Mise N, Suzuki Y, Tada-Oikawa S, Izuoka K, Zhang L, Zong C, Takai A, Yamada Y, Ichihara S
    International journal of molecular sciences 19(4) 2018年04月
  • Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy.
    Kuzuya K, Ichihara S, Suzuki Y, Inoue C, Ichihara G, Kurimoto S, Oikawa S
    PloS one 13(2) e0192624 2018年
  • Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy.
    Ichihara S, Suzuki Y, Chang J, Kuzuya K, Inoue C, Kitamura Y, Oikawa S
    Scientific reports 7(1) 9243 2017年08月
  • Effect of 4-week inhalation exposure to 1-bromopropane on blood pressure in rats.
    Huang F, Ichihara S, Yamada Y, Banu S, Ichihara G
    Journal of applied toxicology : JAT 37(3) 331-338 2017年03月
  • Plasma protein profiling for potential biomarkers in the early diagnosis of Alzheimer's disease.
    Kitamura Y, Usami R, Ichihara S, Kida H, Satoh M, Tomimoto H, Murata M, Oikawa S
    Neurological research 39(3) 231-238 2017年03月
  • Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.
    Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada KH, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A
    PloS one 12(4) e0175649 2017年
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  • NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.
    Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K
    Molecular medicine reports 2018年10月
  • Proteomic Profiling of Exosomal Proteins for Blood-based Biomarkers in Parkinson's Disease.
    Kitamura Y, Kojima M, Kurosawa T, Sasaki R, Ichihara S, Hiraku Y, Tomimoto H, Murata M, Oikawa S
    Neuroscience 392 121-128 2018年09月
  • Pulmonary hypofunction due to calcium carbonate nanomaterial exposure in occupational workers: a cross-sectional study.
    Li G, Liang L, Yang J, Zeng L, Xie Z, Zhong Y, Ruan X, Dong M, Yang Z, Lai G, Huang W, Yang A, Chen J, Wu B, Xu H, Meng D, Hu S, Xia L, Yang X, Li L, Ichihara S, Ichihara G, Huang H, Huang Z
    Nanotoxicology 12(6) 571-585 2018年08月
  • Exposure of Mice to 1,2-Dichloropropane Induces CYP450-Dependent Proliferation and Apoptosis of Cholangiocytes.
    Zhang X, Zong C, Zhang L, Garner E, Sugie S, Huang C, Wu W, Chang J, Sakurai T, Kato M, Ichihara S, Kumagai S, Ichihara G
    Toxicological sciences : an official journal of the Society of Toxicology 162(2) 559-569 2018年04月
  • MicroRNAs as Potential Mediators for Cigarette Smoking Induced Atherosclerosis.
    Yokoyama Y, Mise N, Suzuki Y, Tada-Oikawa S, Izuoka K, Zhang L, Zong C, Takai A, Yamada Y, Ichihara S
    International journal of molecular sciences 19(4) 2018年04月
  • Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy.
    Kuzuya K, Ichihara S, Suzuki Y, Inoue C, Ichihara G, Kurimoto S, Oikawa S
    PloS one 13(2) e0192624 2018年
  • Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy.
    Ichihara S, Suzuki Y, Chang J, Kuzuya K, Inoue C, Kitamura Y, Oikawa S
    Scientific reports 7(1) 9243 2017年08月
  • Effect of 4-week inhalation exposure to 1-bromopropane on blood pressure in rats.
    Huang F, Ichihara S, Yamada Y, Banu S, Ichihara G
    Journal of applied toxicology : JAT 37(3) 331-338 2017年03月
  • Plasma protein profiling for potential biomarkers in the early diagnosis of Alzheimer's disease.
    Kitamura Y, Usami R, Ichihara S, Kida H, Satoh M, Tomimoto H, Murata M, Oikawa S
    Neurological research 39(3) 231-238 2017年03月
  • Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.
    Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada KH, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A
    PloS one 12(4) e0175649 2017年
  • Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease.
    Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M
    Clinical epigenetics 9 54 2017年
  • Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane.
    Zong C, Zhang X, Huang C, Chang J, Garner CE, Sakurai T, Kato M, Ichihara S, Ichihara G
    Toxicology research 5(6) 1522-1529 2016年11月
  • Single- and double-walled carbon nanotubes enhance atherosclerogenesis by promoting monocyte adhesion to endothelial cells and endothelial progenitor cell dysfunction.
    Suzuki Y, Tada-Oikawa S, Hayashi Y, Izuoka K, Kataoka M, Ichikawa S, Wu W, Zong C, Ichihara G, Ichihara S
    Particle and fibre toxicology 13(1) 54 2016年10月
  • Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450.
    Zong C, Garner CE, Huang C, Zhang X, Zhang L, Chang J, Toyokuni S, Ito H, Kato M, Sakurai T, Ichihara S, Ichihara G
    Toxicology letters 258 249-258 2016年09月
  • Titanium Dioxide Particle Type and Concentration Influence the Inflammatory Response in Caco-2 Cells.
    Tada-Oikawa S, Ichihara G, Fukatsu H, Shimanuki Y, Tanaka N, Watanabe E, Suzuki Y, Murakami M, Izuoka K, Chang J, Wu W, Yamada Y, Ichihara S
    International journal of molecular sciences 17(4) 576 2016年04月
  • Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites.
    Nakatochi M, Ichihara S, Yamamoto K, Ohnaka K, Kato Y, Yokota S, Hirashiki A, Naruse K, Asano H, Izawa H, Matsubara T, Yokota M
    Diabetologia 58(12) 2781-2790 2015年12月
  • Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
    Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Leach IM, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor CC, Kleber ME, Li H, Yu Mok Z, Nakatochi M, Sapari NS, Saxena R, Stewart AFR, Stolk L, Tabara Y, Teh AL, Wu Y, Wu JY, Zhang Y, Aits I, Da Silva Couto Alves A, Das S, Dorajoo R, Hopewell JC, Kim YK, Koivula RW, Luan J, Lyytikäinen LP, Nguyen QN, Pereira MA, Postmus I, Raitakari OT, Scannell Bryan M, Scott RA, Sorice R, Tragante V, Traglia M, White J, Yamamoto K, Zhang Y, Adair LS, Ahmed A, Akiyama K, Asif R, Aung T, Barroso I, Bjonnes A, Braun TR, Cai H, Chang LC, Chen CH, Cheng CY, Chong YS, Collins R, Courtney R, Davies G, Delgado G, Do LD, Doevendans PA, Gansevoort RT, Gao YT, Grammer TB, Grarup N, Grewal J, Gu D, Wander GS, Hartikainen AL, Hazen SL, He J, Heng CK, Hixson JE, Hofman A, Hsu C, Huang W, Husemoen LLN, Hwang JY, Ichihara S, Igase M, Isono M, Justesen JM, Katsuya T, Kibriya MG, Kim YJ, Kishimoto M, Koh WP, Kohara K, Kumari M, Kwek K, Lee NR, Lee J, Liao J, Lieb W, Liewald DCM, Matsubara T, Matsushita Y, Meitinger T, Mihailov E, Milani L, Mills R, Mononen N, Müller-Nurasyid M, Nabika T, Nakashima E, Ng HK, Nikus K, Nutile T, Ohkubo T, Ohnaka K, Parish S, Paternoster L, Peng H, Peters A, Pham ST, Pinidiyapathirage MJ, Rahman M, Rakugi H, Rolandsson O, Ann Rozario M, Ruggiero D, Sala CF, Sarju R, Shimokawa K, Snieder H, Sparsø T, Spiering W, Starr JM, Stott DJ, Stram DO, Sugiyama T, Szymczak S, Tang WHW, Tong L, Trompet S, Turjanmaa V, Ueshima H, Uitterlinden AG, Umemura S, Vaarasmaki M, van Dam RM, van Gilst WH, van Veldhuisen DJ, Viikari JS, Waldenberger M, Wang Y, Wang A, Wilson R, Wong TY, Xiang YB, Yamaguchi S, Ye X, Young RD, Young TL, Yuan JM, Zhou X, Asselbergs FW, Ciullo M, Clarke R, Deloukas P, Franke A, Franks PW, Franks S, Friedlander Y, Gross MD, Guo Z, Hansen T, Jarvelin MR, Jørgensen T, Jukema JW, Kähönen M, Kajio H, Kivimaki M, Lee JY, Lehtimäki T, Linneberg A, Miki T, Pedersen O, Samani NJ, Sørensen TIA, Takayanagi R, Toniolo D, BIOS-consortium., CARDIo GRAMplusCD., LifeLines Cohort Study., InterAct Consortium., Ahsan H, Allayee H, Chen YT, Danesh J, Deary IJ, Franco OH, Franke L, Heijman BT, Holbrook JD, Isaacs A, Kim BJ, Lin X, Liu J, März W, Metspalu A, Mohlke KL, Sanghera DK, Shu XO, van Meurs JBJ, Vithana E, Wickremasinghe AR, Wijmenga C, Wolffenbuttel BHW, Yokota M, Zheng W, Zhu D, Vineis P, Kyrtopoulos SA, Kleinjans JCS, McCarthy MI, Soong R, Gieger C, Scott J, Teo YY, He J, Elliott P, Tai ES, van der Harst P, Kooner JS, Chambers JC
    Nature genetics 47(11) 1282-1293 2015年11月
  • Copper Oxide Nanoparticles Reduce Vasculogenesis in Transgenic Zebrafish Through Down-Regulation of Vascular Endothelial Growth Factor Expression and Induction of Apoptosis.
    Chang J, Ichihara G, Shimada Y, Tada-Oikawa S, Kuroyanagi J, Zhang B, Suzuki Y, Sehsah R, Kato M, Tanaka T, Ichihara S
    Journal of nanoscience and nanotechnology 15(3) 2140-2147 2015年03月
  • Hippocampal phosphoproteomics of F344 rats exposed to 1-bromopropane.
    Huang Z, Ichihara S, Oikawa S, Chang J, Zhang L, Hu S, Huang H, Ichihara G
    Toxicology and applied pharmacology 282(2) 151-160 2015年01月
  • [Editor's Note].
    Ichihara S
    Nihon eiseigaku zasshi. Japanese journal of hygiene 70(1) 97 2015年
  • Zn(II) released from zinc oxide nano/micro particles suppresses vasculogenesis in human endothelial colony-forming cells.
    Tada-Oikawa S, Ichihara G, Suzuki Y, Izuoka K, Wu W, Yamada Y, Mishima T, Ichihara S
    Toxicology reports 2 692-701 2015年
  • A trial to find appropriate animal models of dichloropropane-induced cholangiocarcinoma based on the hepatic distribution of glutathione S-transferases.
    Zhang L, Zong C, Ichihara S, Naito H, Toyokuni S, Kumagai S, Ichihara G
    Journal of occupational health 57(6) 548-554 2015年
  • Synergistic effect of bolus exposure to zinc oxide nanoparticles on bleomycin-induced secretion of pro-fibrotic cytokines without lasting fibrotic changes in murine lungs.
    Wu W, Ichihara G, Hashimoto N, Hasegawa Y, Hayashi Y, Tada-Oikawa S, Suzuki Y, Chang J, Kato M, D'Alessandro-Gabazza CN, Gabazza EC, Ichihara S
    International journal of molecular sciences 16(1) 660-676 2014年12月
  • Zinc oxide nanoparticles induce migration and adhesion of monocytes to endothelial cells and accelerate foam cell formation.
    Suzuki Y, Tada-Oikawa S, Ichihara G, Yabata M, Izuoka K, Suzuki M, Sakai K, Ichihara S
    Toxicology and applied pharmacology 278(1) 16-25 2014年07月
  • Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice.
    Yajima I, Iida M, Kumasaka MY, Omata Y, Ohgami N, Chang J, Ichihara S, Hori M, Kato M
    Experimental dermatology 23(6) 424-425 2014年06月
  • The effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice.
    Iida M, Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M
    European journal of dermatology : EJD 24(3) 392-394 2014年05月
  • Association of a polymorphism of BTN2A1 with dyslipidemia in community-dwelling individuals.
    Horibe H, Ueyama C, Fujimaki T, Oguri M, Kato K, Ichihara S, Yamada Y
    Molecular medicine reports 9(3) 808-812 2014年03月
  • A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
    Wu Y, Gao H, Li H, Tabara Y, Nakatochi M, Chiu YF, Park EJ, Wen W, Adair LS, Borja JB, Cai Q, Chang YC, Chen P, Croteau-Chonka DC, Fogarty MP, Gan W, He CT, Hsiung CA, Hwu CM, Ichihara S, Igase M, Jo J, Kato N, Kawamoto R, Kuzawa CW, Lee JJ, Liu J, Lu L, McDade TW, Osawa H, Sheu WH, Teo Y, Vadlamudi S, Van Dam RM, Wang Y, Xiang YB, Yamamoto K, Ye X, Young TL, Zheng W, Zhu J, Shu XO, Shin C, Jee SH, Chuang LM, Miki T, Yokota M, Lin X, Mohlke KL, Tai ES
    Human molecular genetics 23(4) 1108-1119 2014年02月
  • High-phosphorus/zinc-free diet aggravates hypertension and cardiac dysfunction in a rat model of the metabolic syndrome.
    Suzuki Y, Mitsushima S, Kato A, Yamaguchi T, Ichihara S
    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 23(1) 43-49 2014年01月
  • Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat.
    Chang J, Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Aoki C, Yamada Y, Ichihara G, Kato M, Ichihara S
    Diabetology & metabolic syndrome 6(1) 8 2014年01月
  • Dispersion method for safety research on manufactured nanomaterials.
    Wu W, Ichihara G, Suzuki Y, Izuoka K, Oikawa-Tada S, Chang J, Sakai K, Miyazawa K, Porter D, Castranova V, Kawaguchi M, Ichihara S
    Industrial health 52(1) 54-65 2014年
  • Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis.
    Ichihara S, Yamamoto K, Asano H, Nakatochi M, Sukegawa M, Ichihara G, Izawa H, Hirashiki A, Takatsu F, Umeda H, Iwase M, Inagaki H, Hirayama H, Sone T, Nishigaki K, Minatoguchi S, Cho MC, Jang Y, Kim HS, Park JE, Tada-Oikawa S, Kitajima H, Matsubara T, Sunagawa K, Shimokawa H, Kimura A, Lee JY, Murohara T, Inoue I, Yokota M
    Circulation. Cardiovascular genetics 6(6) 569-578 2013年12月
  • Rats with metabolic syndrome resist the protective effects of N-acetyl l-cystein against impaired spermatogenesis induced by high-phosphorus/zinc-free diet.
    Suzuki Y, Ichihara G, Sahabudeen SM, Kato A, Yamaguchi T, Imanaka-Yoshida K, Yoshida T, Yamada Y, Ichihara S
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 65(7-8) 1173-1182 2013年11月
  • Association of a polymorphism of BTN2A1 with chronic kidney disease in community-dwelling individuals.
    Oguri M, Fujimaki T, Horibe H, Kato K, Ichihara S, Yamada Y
    Biomedical reports 1(6) 868-872 2013年11月
  • Serial changes in adipocytokines and cardiac function in a rat model of the metabolic syndrome.
    Yamaguchi T, Kitamori K, Ichihara G, Suzuki Y, Ochiai M, Yamada Y, Tada-Oikawa S, Tsuchikura S, Yamori Y, Ichihara S
    Clinical and experimental pharmacology & physiology 40(7) 443-448 2013年07月
  • Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study.
    Yamada Y, Nishida T, Ichihara S, Kato K, Fujimaki T, Oguri M, Horibe H, Yoshida T, Watanabe S, Satoh K, Aoyagi Y, Fukuda M, Sawabe M
    Journal of medical genetics 50(6) 410-418 2013年06月
  • The pathological roles of environmental and redox stresses in cardiovascular diseases.
    Ichihara S
    Environmental health and preventive medicine 18(3) 177-184 2013年05月
  • Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats.
    Zhang L, Nagai T, Yamada K, Ibi D, Ichihara S, Subramanian K, Huang Z, Mohideen SS, Naito H, Ichihara G
    Toxicology 304 76-82 2013年02月
  • Effects of exposure to 1-bromopropane on astrocytes and oligodendrocytes in rat brain.
    Mohideen SS, Ichihara S, Subramanian K, Huang Z, Naito H, Kitoh J, Ichihara G
    Journal of occupational health 55(1) 29-38 2013年
  • Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum.
    Subramanian K, Mohideen SS, Suzumura A, Asai N, Murakumo Y, Takahashi M, Jin S, Zhang L, Huang Z, Ichihara S, Kitoh J, Ichihara G
    Toxicology 302(1) 18-24 2012年12月
  • Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat.
    Chang J, Oikawa S, Ichihara G, Nanpei Y, Hotta Y, Yamada Y, Tada-Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Ichihara S
    Nutrition & metabolism 9(1) 87 2012年09月
  • Proteomic identification of carbonylated proteins in F344 rat hippocampus after 1-bromopropane exposure.
    Huang Z, Ichihara S, Oikawa S, Chang J, Zhang L, Subramanian K, Mohideen SS, Ichihara G
    Toxicology and applied pharmacology 263(1) 44-52 2012年08月
  • Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane.
    Huang Z, Ichihara S, Oikawa S, Chang J, Zhang L, Takahashi M, Subramanian K, Mohideen SS, Wang Y, Ichihara G
    Toxicology and applied pharmacology 257(1) 93-101 2011年11月
  • Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane: authors' response.
    Ichihara G, Wang H, Zhang L, Wakai K, Li W, Ding X, Shibata E, Zhou Z, Wang Q, Li J, Ichihara S, Takeuchi Y
    Journal of occupational and environmental medicine 53(10) 1095-1098 2011年10月
  • Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain.
    Mohideen SS, Ichihara G, Ichihara S, Nakamura S
    Toxicology 285(1-2) 67-71 2011年07月
  • The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic syndrome in an aged Japanese population: results from the KING Study.
    Nakatochi M, Miyata S, Tanimura D, Izawa H, Asano H, Murase Y, Kato R, Ichihara S, Naruse K, Matsubara T, Honda H, Yokota M
    Diabetes research and clinical practice 92(3) e61-5 2011年06月
  • Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population.
    Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M
    European journal of human genetics : EJHG 19(3) 262-269 2011年03月
  • Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.
    Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, Aoyagi Y, Tanaka M, Fujiwara Y, Yoshida H, Shinkai S, Satoh K, Kato K, Fujimaki T, Yokoi K, Oguri M, Yoshida T, Watanabe S, Nozawa Y, Hasegawa A, Kojima T, Han BG, Ahn Y, Lee M, Shin DJ, Lee JH, Jang Y
    Atherosclerosis 215(1) 145-152 2011年03月
  • Pleural plaque profiles on the chest radiographs and CT scans of asbestos-exposed Japanese construction workers.
    Elshazley M, Shibata E, Hisanaga N, Ichihara G, Ewis AA, Kamijima M, Ichihara S, Sakai K, Sato M, Kondo M, Hasegawa Y
    Industrial health 49(5) 626-633 2011年
  • Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response.
    Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G
    Arteriosclerosis, thrombosis, and vascular biology 30(8) 1553-1561 2010年08月
  • Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane.
    Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G
    Journal of occupational and environmental medicine 52(8) 769-777 2010年08月
  • Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity.
    Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Sheik Mohideen S, Kitoh J, Ichihara G
    Toxicological sciences : an official journal of the Society of Toxicology 115(2) 596-606 2010年06月
  • Beneficial effects of growth hormone-releasing peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters.
    Kato Y, Iwase M, Ichihara S, Kanazawa H, Hashimoto K, Noda A, Nagata K, Koike Y, Yokota M
    Circulation journal : official journal of the Japanese Circulation Society 74(1) 163-170 2010年01月
  • Changes in neurotransmitter receptor expression levels in rat brain after 4-week exposure to 1-bromopropane.
    Mohideen SS, Ichihara S, Banu S, Liu F, Kitoh J, Ichihara G
    Neurotoxicology 30(6) 1078-1083 2009年11月
  • Comparative study on susceptibility to 1-bromopropane in three mice strains.
    Liu F, Ichihara S, Mohideen SS, Sai U, Kitoh J, Ichihara G
    Toxicological sciences : an official journal of the Society of Toxicology 112(1) 100-110 2009年11月
  • Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor.
    Ichihara S, Yamada Y, Gonzalez FJ, Nakajima T, Murohara T, Ichihara G
    Biochemical and biophysical research communications 381(1) 44-49 2009年03月
  • Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals.
    Yamada Y, Metoki N, Yoshida H, Satoh K, Kato K, Hibino T, Yokoi K, Watanabe S, Ichihara S, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y
    Stroke 39(8) 2211-2218 2008年08月
  • Association of a polymorphism of ABCB1 with obesity in Japanese individuals.
    Ichihara S, Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, Kojima T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y
    Genomics 91(6) 512-516 2008年06月
  • Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome.
    Yamada Y, Kato K, Oguri M, Yoshida T, Yokoi K, Watanabe S, Metoki N, Yoshida H, Satoh K, Ichihara S, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y
    International journal of molecular medicine 21(6) 801-808 2008年06月
  • Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals.
    Yamada Y, Kato K, Yoshida T, Yokoi K, Matsuo H, Watanabe S, Ichihara S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y
    International journal of molecular medicine 21(1) 83-89 2008年01月
  • Molecular genetics of myocardial infarction.
    Yamada Y, Ichihara S, Nishida T
    Genomic medicine 2(1-2) 7-22 2008年01月
  • Proinflammatory gene polymorphisms and ischemic stroke.
    Yamada Y, Ichihara S, Nishida T
    Current pharmaceutical design 14(33) 3590-3600 2008年
  • Reversibility of the adverse effects of 1-bromopropane exposure in rats.
    Banu S, Ichihara S, Huang F, Ito H, Inaguma Y, Furuhashi K, Fukunaga Y, Wang Q, Kitoh J, Ando H, Kikkawa F, Ichihara G
    Toxicological sciences : an official journal of the Society of Toxicology 100(2) 504-512 2007年12月
  • Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus.
    Yamada Y, Matsuo H, Watanabe S, Kato K, Yajima K, Hibino T, Yokoi K, Ichihara S, Metoki N, Yoshida H, Satoh K, Nozawa Y
    International journal of molecular medicine 20(5) 703-707 2007年11月
  • Prediction of genetic risk for dyslipidemia.
    Yamada Y, Matsuo H, Warita S, Watanabe S, Kato K, Oguri M, Yokoi K, Metoki N, Yoshida H, Satoh K, Ichihara S, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y
    Genomics 90(5) 551-558 2007年11月
  • Differential cardiovascular effects of endotoxin derived from Escherichia coli or Pseudomonas aeruginosa.
    Matsushita A, Iwase M, Kato Y, Ichihara S, Ichihara G, Kimata H, Hayashi K, Hashimoto K, Yokoi T, Noda A, Koike Y, Yokota M, Nagata K
    Experimental animals 56(5) 339-348 2007年10月
  • Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity.
    Ichihara S, Yamada Y, Kawai Y, Osawa T, Furuhashi K, Duan Z, Ichihara G
    Biochemical and biophysical research communications 359(1) 27-33 2007年07月
  • A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis.
    Ichihara S, Yamada Y, Ichihara G, Nakajima T, Li P, Kondo T, Gonzalez FJ, Murohara T
    Arteriosclerosis, thrombosis, and vascular biology 27(6) 1297-1304 2007年06月
  • Prediction of genetic risk for metabolic syndrome.
    Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, Segawa T, Watanabe S, Ichihara S, Yoshida H, Satoh K, Nozawa Y
    Atherosclerosis 191(2) 298-304 2007年04月
  • Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus.
    Yamaguchi S, Yamada Y, Matsuo H, Segawa T, Watanabe S, Kato K, Yokoi K, Ichihara S, Metoki N, Yoshida H, Satoh K, Nozawa Y
    International journal of molecular medicine 19(4) 631-637 2007年04月
  • Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors.
    Nishihama K, Yamada Y, Matsuo H, Segawa T, Watanabe S, Kato K, Yajima K, Hibino T, Yokoi K, Ichihara S, Metoki N, Yoshida H, Satoh K, Nozawa Y
    International journal of molecular medicine 19(1) 129-141 2007年01月
  • Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway.
    Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Noda A, Izawa H, Nagata K, Yokota M
    Clinical and experimental pharmacology & physiology 33(12) 1164-1171 2006年12月
  • Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy.
    Ichihara S, Yamada Y, Ichihara G, Kanazawa H, Hashimoto K, Kato Y, Matsushita A, Oikawa S, Yokota M, Iwase M
    Biochemical and biophysical research communications 350(1) 105-113 2006年11月
  • Genetic factors for obesity.
    Yamada Y, Kato K, Kameyama T, Yokoi K, Matsuo H, Segawa T, Watanabe S, Ichihara S, Yoshida H, Satoh K, Nozawa Y
    International journal of molecular medicine 18(5) 843-851 2006年11月
  • Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis.
    Yamaguchi S, Yamada Y, Metoki N, Yoshida H, Satoh K, Ichihara S, Kato K, Kameyama T, Yokoi K, Matsuo H, Segawa T, Watanabe S, Nozawa Y
    International journal of molecular medicine 18(5) 871-883 2006年11月
  • Assessment of the genetic component of hypertension.
    Yamada Y, Matsuo H, Segawa T, Watanabe S, Kato K, Hibino T, Yokoi K, Ichihara S, Metoki N, Yoshida H, Satoh K, Nozawa Y
    American journal of hypertension 19(11) 1158-1165 2006年11月
  • Genetic risk for ischemic and hemorrhagic stroke.
    Yamada Y, Metoki N, Yoshida H, Satoh K, Ichihara S, Kato K, Kameyama T, Yokoi K, Matsuo H, Segawa T, Watanabe S, Nozawa Y
    Arteriosclerosis, thrombosis, and vascular biology 26(8) 1920-1925 2006年08月
  • Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors.
    Ichihara S, Obata K, Yamada Y, Nagata K, Noda A, Ichihara G, Yamada A, Kato T, Izawa H, Murohara T, Yokota M
    Journal of molecular and cellular cardiology 41(2) 318-329 2006年08月
  • Assessment of genetic factors for type 2 diabetes mellitus.
    Yamada Y, Matsuo H, Segawa T, Watanabe S, Kato K, Kameyama T, Yokoi K, Ichihara S, Metoki N, Yoshida H, Satoh K, Nozawa Y
    International journal of molecular medicine 18(2) 299-308 2006年08月
  • Assessment of genetic risk for myocardial infarction.
    Yamada Y, Matsuo H, Segawa T, Watanabe S, Kato K, Hibino T, Yokoi K, Ichihara S, Metoki N, Yoshida H, Satoh K, Nozawa Y
    Thrombosis and haemostasis 96(2) 220-227 2006年08月
  • Effects of exposure of rat dams to 1-bromopropane during pregnancy and lactation on growth and sexual maturation of their offspring.
    Furuhashi K, Kitoh J, Tsukamura H, Maeda K, Wang H, Li W, Ichihara S, Nakajima T, Ichihara G
    Toxicology 224(3) 219-228 2006年07月
  • Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure.
    Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Nishizawa T, Noda A, Izawa H, Nagata K, Murohara T, Yokota M
    Journal of cardiovascular pharmacology 47(6) 770-779 2006年06月
  • Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats.
    Nagata K, Obata K, Xu J, Ichihara S, Noda A, Kimata H, Kato T, Izawa H, Murohara T, Yokota M
    Hypertension (Dallas, Tex. : 1979) 47(4) 656-664 2006年04月
  • Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure.
    Ichihara S, Noda A, Nagata K, Obata K, Xu J, Ichihara G, Oikawa S, Kawanishi S, Yamada Y, Yokota M
    Cardiovascular research 69(3) 726-735 2006年02月
  • Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study.
    Izawa H, Murohara T, Nagata K, Isobe S, Asano H, Amano T, Ichihara S, Kato T, Ohshima S, Murase Y, Iino S, Obata K, Noda A, Okumura K, Yokota M
    Circulation 112(19) 2940-2945 2005年11月
  • Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats.
    Xu J, Nagata K, Obata K, Ichihara S, Izawa H, Noda A, Nagasaka T, Iwase M, Naoe T, Murohara T, Yokota M
    Hypertension (Dallas, Tex. : 1979) 46(4) 719-724 2005年10月
  • Serial alterations of beta-adrenergic signaling in dilated cardiomyopathic hamsters: possible role of myocardial oxidative stress.
    Nishizawa T, Iwase M, Kanazawa H, Ichihara S, Ichihara G, Nagata K, Obata K, Kitaichi K, Yokoi T, Watanabe M, Tsunematsu T, Ishikawa Y, Murohara T, Yokota M
    Circulation journal : official journal of the Japanese Circulation Society 68(11) 1051-1060 2004年11月
  • Lack of association of polymorphisms of the lymphotoxin alpha gene with myocardial infarction in Japanese.
    Yamada A, Ichihara S, Murase Y, Kato T, Izawa H, Nagata K, Murohara T, Yamada Y, Yokota M
    Journal of molecular medicine (Berlin, Germany) 82(7) 477-483 2004年07月
  • Genetic risk and gene-environment interaction in coronary artery spasm in Japanese men and women.
    Murase Y, Yamada Y, Hirashiki A, Ichihara S, Kanda H, Watarai M, Takatsu F, Murohara T, Yokota M
    European heart journal 25(11) 970-977 2004年06月
  • Genetic risk for restenosis after coronary balloon angioplasty.
    Horibe H, Yamada Y, Ichihara S, Watarai M, Yanase M, Takemoto K, Shimizu S, Izawa H, Takatsu F, Yokota M
    Atherosclerosis 174(1) 181-187 2004年05月
  • Genetic risk for coronary artery disease in individuals with or without type 2 diabetes.
    Yamada Y, Ichihara S, Izawa H, Tanaka M, Yokota M
    Molecular genetics and metabolism 81(4) 282-290 2004年04月
  • Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia.
    Shimokata K, Yamada Y, Kondo T, Ichihara S, Izawa H, Nagata K, Murohara T, Ohno M, Yokota M
    Atherosclerosis 172(1) 167-173 2004年01月
  • Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect.
    Nagata K, Obata K, Odashima M, Yamada A, Somura F, Nishizawa T, Ichihara S, Izawa H, Iwase M, Hayakawa A, Murohara T, Yokota M
    Journal of molecular and cellular cardiology 35(12) 1505-1512 2003年12月
  • Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.
    Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, Sone T, Tanaka M, Yokota M
    The New England journal of medicine 347(24) 1916-1923 2002年12月
  • Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction.
    Ichihara S, Senbonmatsu T, Price E Jr, Ichiki T, Gaffney FA, Inagami T
    Circulation 106(17) 2244-2249 2002年10月
  • AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats.
    Nagata K, Somura F, Obata K, Odashima M, Izawa H, Ichihara S, Nagasaka T, Iwase M, Yamada Y, Nakashima N, Yokota M
    Hypertension (Dallas, Tex. : 1979) 40(2) 168-174 2002年08月

外部的資金

  • 環境化学物質の心血管系システムへの影響
    :共同研究
    研究期間 :2005年
  • メタボリック症候群における心血管障害の機序の解明
    :共同研究
    研究期間 :2004年
  • 喫煙による循環器系への影響
    :共同研究
    研究期間 :2003年 - 2007年
外部資金採択状況を全て表示する
外部資金採択状況閉じる
  • 環境化学物質の心血管系システムへの影響
    :共同研究
    研究期間 :2005年
  • メタボリック症候群における心血管障害の機序の解明
    :共同研究
    研究期間 :2004年
  • 喫煙による循環器系への影響
    :共同研究
    研究期間 :2003年 - 2007年


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