永島 秀一 (ﾅｶﾞｼﾏ ｼｭｳｲﾁ)

研究者情報

ホームページURL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201401095853788596

科研費研究者番号

• 30406136

J-Global ID

• 201401095853788596

研究キーワード

• 肝臓   コレステロール   肝障害   ノックアウト   ヒト   リポ蛋白リパーゼ   マウス   マクロファージ   アルブミン   インスリン抵抗性   肥満   HMG-CoA還元酵素   トリグリセリド   脂肪細胞   IMG-CoA還元酵素   動脈硬化   リパーゼ   脂肪酸   スクワレン合成酵素   遺伝子発現   

研究分野

• ライフサイエンス / 代謝、内分泌学
• ライフサイエンス / 消化器内科学

経歴

• 2020年10月  自治医科大学附属さいたま医療センター内分泌代謝科准教授
• 2015年  自治医科大学内科学講座内分泌代謝学部門講師
• 2014年  自治医科大学医学部助教

研究活動情報

論文

• Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages

  Sakai, Kent, Nagashima, Shuichi, Wakabayashi, Tetsuji, Tumenbayar, Bayasgalan, Hayakawa, Hiroko, Hayakawa, Morisada, Karasawa, Tadayoshi, Ohashi, Ken, Yamazaki, Hisataka, Takei, Akihito, Takei, Shoko, Yamamuro, Daisuke, Takahashi, Manabu, Yagyu, Hiroaki, Osuga, Jun-ichi, Takahashi, Masafumi, Tominaga, Shin-ichi, Ishibashi, Shun

  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 38 11 2590 - 2600 LIPPINCOTT WILLIAMS & WILKINS 2018年11月 [査読有り][通常論文]
  
• Depot-Specific Expression of Lipolytic Genes in Human Adipose Tissues - Association Among CES1 Expression, Triglyceride Lipase Activity and Adiposity

  Shuichi Nagashima, Hiroaki Yagyu, Nirei Takahashi, Tomoyuki Kurashina, Manabu Takahashi, Takeshi Tsuchita, Fumiko Tazoe, Xiao Li Wang, Tumenbayar Bayasgalan, Naoko Sato, Kenta Okada, Shoichiro Nagasaka, Takaya Gotoh, Masayuki Kojima, Masanobu Hyodo, Hisanaga Horie, Yoshinori Hosoya, Masaki Okada, Yoshikazu Yasuda, Hiroyuki Fujiwara, Michitaka Ohwada, Sadahiko Iwamoto, Mitsuaki Suzuki, Hideo Nagai, Shun Ishibashi

  JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18 3 190 - 199 2011年 [査読有り][通常論文]
   

  Aim: Adipocyte lipolysis is mediated by a family of triglyceride (TG) lipases consisting of hormone-sensitive lipase (LIPE), adipose triglyceride lipase (PNPLA2) and carboxylesterase 1 (CES1); however, little is known about the relationship between the expression of each gene in different depots and TG lipase activity or obesity Method: We measured both mRNA expression levels of the lipolytic enzymes (LIPE, PNPLA2 and CES1) and TG lipase activities of biopsy samples obtained from subcutaneous, omental and mesenteric adipose tissues of 34 patients who underwent abdominal surgery. The results were correlated with clinical parameters: adiposity measures, parameters for insulin resistance and plasma lipid levels. Results: PNPLA2 mRNA levels were slightly higher in omental fat than subcutaneous fat. Cytosolic TG lipase activities were positively correlated with the mRNA levels of CES1 in subcutaneous fat and mesenteric fat, while they were correlated with those of PNPLA2 in omental fat. The mRNA levels of LIPE were negatively correlated with various measures of adiposity in subcutaneous fat. The mRNA levels of CES1 were positively correlated with various measures of adiposity, particularly those estimated by CT in the three depots; they were also positively correlated with plasma LDL-cholesterol levels in omental fat. In contrast, the mRNA levels of PNPLA2 were not significantly associated with adiposity. Conclusions: The positive correlations of the expression of CES1 with cytosolic TG lipase activities as well as with adiposity suggest that CES1 is involved in lipolysis, thereby contributing to the development of obesity-associated phenotypes. On the other hand, the expression of LIPE is negatively correlated with adiposity. These distinct regulatory patterns of lipolytic genes may underlie the complex phenotypes associated with human obesity.