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石橋 俊 イシバシ シュン

所属部署名内科学講座内分泌代謝学部門
職名教授ホームページURL

プロフィール

研究分野

  • 内科系臨床医学 / 代謝学

学位

  • 医学博士

研究活動

MISC

  • Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.
    AMEMIYA‐KUDO Michiyo, OKA Junko, IDE Tomohiro, MATSUZAKA Takashi, SONE Hirohito, YOSHIKAWA Tomohiro, YAHAGI Naoya, ISHIBASHI Shun, OSUGA Jun‐ichi, YAMADA Nobuhiro, MURASE Toshio, SHIMANO Hitoshi
    J Biol Chem 280(41) 34577-34589 2005年
  • High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.
    J Biol Chem 280: 27523-27532 2005年
  • Japan Diabetes Complications Study: Is the diagnosis of metabolic syndrome useful for predicting cardiovascular disease in asian diabetic patients? Analysis from the Japan Diabetes Complications Study.
    SONE H, MIZUNO S, FUJII H, YOSHIMURA Y, YAMASAKI Y, ISHIBASHI S, KATAYAMA S, SAITO Y, ITO H, OHASHI Y, AKANUMA Y, YAMADA N
    Diabetes Care 28(6) 1463-1471 2005年
  • Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.
    YAHAGI N, SHIMANO H, HASEGAWA K, OHASHI K, MATSUZAKA T, NAJIMA Y, SEKIYA M, TOMITA S, OKAZAKI H, TAMURA Y, IIZUKA Y, OHASHI K, NAGAI R, ISHIBASHI S, KADOWAKI T, MAKUUCHI M, OHNISHI S, OSUGA J, YAMADA N
    Eur J Cancer 41(9) 1316-1322 2005年
  • A single bout of exercise at higher intensity enhances glucose effectiveness in sedentary men.
    HAYASHI Y, NAGASAKA S, TAKAHASHI N, KUSAKA I, ISHIBASHI S, NUMAO S, LEE Dj, TAKI Y, OGATA H, TOKUYAMA K, TANAKA K
    J Clin Endocinol Metab 90(7) 4035-4040 2005年
  • Diabetic lipemia with eruptive xanthomatosis in a lean young female with apolipoprotein E4/4.
    SHINOZAKI S, ITABASHI N, ROKKAKU K, ICHIKI K, NAGASAKA S, OKADA K, FUJIMOTO M, OHTSUKI M, ISHIBASHI S
    Diabetes Res Clin Pract 70(2) 183-192 2005年
  • Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo.
    HARADA-SHIBA M, TAKAGI A, MARUTSUKA K, MORIGUCHI S, YAGYU H, ISHIBASHI S, ASADA Y, YOKOYAMA S
    Circulation Res 95(9) 945-952 2004年
  • Requirement for hypertension and hyperlipidemia medication in U.S. and Japanese patients with diabetes.
    SONE H, YAMADA N, MIZUNO S, OHASHI Y, ISHIBASHI S
    Am J Med 117(9) 711-712 2004年
  • Scavenger receptor expressed by endothelial cells-l mediates the uptake of acetylated LDL by macrophages stimulated with lipopolysaccharide.
    TAMURA Y, OSUGA J, ADACHI H, INABA T, YAGYU H, KAMADA N, SUZUKI H, SHIMANO H, YAMADA N
    J Biol Chem 279(30) 30938-30944 2004年
  • Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats.
    FUJISAWA G, OKADA K, MUTO S, FUJITA N, ITABASHI N, KUSANO E, ISHIBASHI S
    Kidney Intern 66(4) 1493-1502 2004年
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  • Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.
    AMEMIYA‐KUDO Michiyo, OKA Junko, IDE Tomohiro, MATSUZAKA Takashi, SONE Hirohito, YOSHIKAWA Tomohiro, YAHAGI Naoya, ISHIBASHI Shun, OSUGA Jun‐ichi, YAMADA Nobuhiro, MURASE Toshio, SHIMANO Hitoshi
    J Biol Chem 280(41) 34577-34589 2005年
  • High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.
    J Biol Chem 280: 27523-27532 2005年
  • Japan Diabetes Complications Study: Is the diagnosis of metabolic syndrome useful for predicting cardiovascular disease in asian diabetic patients? Analysis from the Japan Diabetes Complications Study.
    SONE H, MIZUNO S, FUJII H, YOSHIMURA Y, YAMASAKI Y, ISHIBASHI S, KATAYAMA S, SAITO Y, ITO H, OHASHI Y, AKANUMA Y, YAMADA N
    Diabetes Care 28(6) 1463-1471 2005年
  • Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.
    YAHAGI N, SHIMANO H, HASEGAWA K, OHASHI K, MATSUZAKA T, NAJIMA Y, SEKIYA M, TOMITA S, OKAZAKI H, TAMURA Y, IIZUKA Y, OHASHI K, NAGAI R, ISHIBASHI S, KADOWAKI T, MAKUUCHI M, OHNISHI S, OSUGA J, YAMADA N
    Eur J Cancer 41(9) 1316-1322 2005年
  • A single bout of exercise at higher intensity enhances glucose effectiveness in sedentary men.
    HAYASHI Y, NAGASAKA S, TAKAHASHI N, KUSAKA I, ISHIBASHI S, NUMAO S, LEE Dj, TAKI Y, OGATA H, TOKUYAMA K, TANAKA K
    J Clin Endocinol Metab 90(7) 4035-4040 2005年
  • Diabetic lipemia with eruptive xanthomatosis in a lean young female with apolipoprotein E4/4.
    SHINOZAKI S, ITABASHI N, ROKKAKU K, ICHIKI K, NAGASAKA S, OKADA K, FUJIMOTO M, OHTSUKI M, ISHIBASHI S
    Diabetes Res Clin Pract 70(2) 183-192 2005年
  • Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo.
    HARADA-SHIBA M, TAKAGI A, MARUTSUKA K, MORIGUCHI S, YAGYU H, ISHIBASHI S, ASADA Y, YOKOYAMA S
    Circulation Res 95(9) 945-952 2004年
  • Requirement for hypertension and hyperlipidemia medication in U.S. and Japanese patients with diabetes.
    SONE H, YAMADA N, MIZUNO S, OHASHI Y, ISHIBASHI S
    Am J Med 117(9) 711-712 2004年
  • Scavenger receptor expressed by endothelial cells-l mediates the uptake of acetylated LDL by macrophages stimulated with lipopolysaccharide.
    TAMURA Y, OSUGA J, ADACHI H, INABA T, YAGYU H, KAMADA N, SUZUKI H, SHIMANO H, YAMADA N
    J Biol Chem 279(30) 30938-30944 2004年
  • Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats.
    FUJISAWA G, OKADA K, MUTO S, FUJITA N, ITABASHI N, KUSANO E, ISHIBASHI S
    Kidney Intern 66(4) 1493-1502 2004年
  • Research Committeon Primary Hyperlipidemia of the Ministry of Health, Labour, and Welfare of Japan: Clinical features of familial hypercholesterolemia in Japan in a database from 1996-1998 by the research committee of the ministry of health.
    BUJO H, TAKAHASHI K, MARUYAMA T, YAMASHITA S, MATSUZAWA Y, ISHIBASHI S, SHIONOIRI F, YAMADA N, KITA T
    J Atherosclerosis Thrombosis 11(3) 146-151 2004年
  • Research Committeon Primary Hyperlipidemia of the Ministry of Health and Welfare of Japan: Mutations in Japanese subjects with primary hyperlipidemia-results from the Ministry of Health and Welfare of Japan since 1996-.
    MARUYAMA T, MATSUZAWA Y, BUJO H, KITA T, ISHIBASHI S, OHASHI K, SHIONOIRI F, GOTODA T, YAMADA N
    J Atherosclerosis Thrombosis 11(3) 131-145 2004年
  • Hormone-sensitive lipase is required for HDL cholesteryl ester-mediated adrenal steroidogenesis.
    AZHAR S, ISHIBASHI S, OSUGA Ji, PATEL S, HARADA K, SHEN Wj, KRAEMER Fb
    Mol Endocrinol 18(3) 549-557 2004年
  • Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis.
    SATA M, NISHIMATSU H, OSUGA J, TANAKA K, ISHIZAKA N, ISHIBASHI S, HIRATA Y, NAGAI R
    Hpertension 43(6) 1214-1220 2004年
  • p53 involvement in the pathogenesis of fatty liver disease.
    YAHAGI N, SHIMANO H, MATSUZAKA T, SEKIYA M, NAJIMA Y, OKAZAKI S, INOUE N, NAKAGAWA Y, TAKEUCHI Y
    J Biol Chem 279(20) 20571-20575 2004年
  • A case of thymic enlargement in hyperthyroidism in a young woman.
    NAKAMURA T, MURAKAMI M, HORIGUCHI H, NAGASAKA S, ISHIBASHI S, MORI M, ISHIKAWA Se
    Thyroid 14(4) 307-310 2004年
  • Decrease in serum C-reactive protein levels by troglitazone is associated with pretreatment insulin resistance, but independent of its effect on glycemia, in type 2 diabetic subjects.
    YATAGAI T, NAKAMURA T, NAGASAKA S, KUSAKA I, ISHIKAWA S, YOSHITAKA A, ISHIBASHI S
    Diabetes Res Clin Prac 63(1) 19-26 2004年
  • Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.
    MATSUZAKA T, SHIMANO H, YAHAGI N, AMEMIYA-KUDO M, OKAZAKI H, TAMURA Y, IIZUKA Y, OHASHI K, TOMITA S, SEKIYA M, HASTY A, NAKAGAWA Y, SONE H, TOYOSHIMA H, ISHIBASHI S, OSUGA J, YAMADA N
    Diabetes 53(3) 560-569 2004年
  • Absence of hormone-sensetive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.
    SEKIYA M, OSUGA J, OKAZAKI H, HARADA K, SHEN W‐J, OKAZAKI M, SHIMANO H, KRAEMER F B, YAMADA N
    J Biol Chem 279(15) 15084-15090 2004年
  • Comparison of pioglitazone and metformin efficacy using homeostasis model assessment.
    NAGASAKA S, AISO Y, YOSHIZAWA K, ISHIBASHI S
    Diabetic Med 21(2) 136-141 2004年
  • Effect of moderate exercise training on peripheral glucose effectiveness, insulin sensitivity, and endogenous glucose production in healthy humans estimated by a two-compartment-labeled minimal model.
    NISHIDA Y, TOKUYAMA K, NAGASAKA S, HIGAKI Y, SHIRAI Y, KIYONAGA A, SHINDO M, KUSAKA I, NAKAMURA T, ISHIBASHI S, TANAKA H
    Diabetes 53(2) 315-320 2004年
  • HLA-DR-DQ haplotype in rapid-onset type 1 diabetes in Japanese.
    NAKAMURA T, NAGASAKA S, KUSAKA I, YATAGAI T, YANG Jm, ISHIBASHI S
    Diabetes Care 26(5) 1640-1641 2003年
  • FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
    TAMURA Y, ADACHI H, OSUGA J, IIZUKA Y, SHIMANO H, NAGAI R, KIMURA S, TSUJIMOTO M, ISHIBASHI S
    J Biol Chem 278(15) 12613-12617 2003年
  • Na/H exchange isoform 1 is involved in mineralocorticoid/salt-induced cardiac injury.
    FUJISAWA G, OKADA K, MUTO S, FUJITA N, ITABASHI N, KUSANO E, ISHIBASHI S
    Hypertension 41(3) 493-498 2003年
  • Effect of glimepiride on serum adiponectin level in subjects with type 2 diabetes.
    Diabetes Care 26: 2215-2216 2003年
  • Close association of severe hyponatremia with exaggerated release of arginine vasopressin in elderly subjects with secondary adrenal insufficiency.
    YATAGAI T, KUSAKA I, NAKAMURA T, NAGASAKA S, HONDA K, ISHIBASHI S, ISHIKAWA S
    Eur J Endocrinol 148(2) 221-226 2003年
  • p53 activation in adipocytes of obese mice.
    YAHAGI N, SHIMANO H, MATSUZAKA T, NAJIMA Y, SEKIYA M, NAKAGAWA Y, IDE T, TOMITA S, YAMADA N
    J Biol Chem 278(28) 25395-25400 2003年
  • Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism, II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
    OHASHI K, TAKAHASHI A, SONE H, GOTODA T, OSUGA Ji, ISHIBASHI S, YAMADA N, TOMITA S, IIZUKA Y, YATOH S, IDE T, SHIMANO H, YOSHIKAWA T, YAHAGI N, AMEMIYA-KUDO M, MATSUZAKA T, NAKAKUKI M
    Mol Endocrinol 17(7) 1255-1267 2003年
  • Relationship between exercise training-induced increase in insulin sensitivity and adiponectinemia in healthy men.
    YATAGAI T, NISHIDA Y, NAGASAKA S, NAKAMURA T, TOKUYAMA K, SHINDO M, TANAKA H, ISHIBASHI S
    Endocr J 50(2) 233-238 2003年
  • Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR ・・・
    SEKIYA M, TAKAHASHI A, HASTY Ah, SATO R, SONE H, OSUGA Ji, ISHIBASHI S, YAMADA N, TAMURA Y, OKAZAKI H, YOSHIKAWA T, IDE T, SHIMANO H, YAHAGI N, AMEMIYA-KUDO M, MATSUZAKA T, YATOH S, KITAMINE T
    Mol Endocrinol 17(7) 1240-1254 2003年
  • Early embryonic lethality caused by targeted disruption of the HMG-CoA reductase gene.
    OHASHI K, OSUGA J, TOZAWA R, YAGYU H, HARADA K, GOTODA T, SHIMANO H, YAMADA N, ISHIBASHI S
    J Biol Chem. 278(44) 42936-42941 2003年
  • Resistance to high fat diet-induced obesity associated with altered expression of adipose specific genes in hormone-sensitive lipase deficient mice.
    Am J Physiol Endocrinol Metab. 285:E1182-95 2003年
  • Neuromedin U facilitates oxytocin release from the pituitary via β adrenoceptors.
    ROKKAKU K, ONAKA T, OKADA N, IDENO J, KAWAKAMI A, HONDA K, YADA T, ISHIBASHI S
    NeuroReport 14(15) 1997-2000 2003年
  • Roles of immunoglobulin-like loops of junctional cell adhesion molecule 4; involvement in the subcellular localization and the cell adhesion.
    TAJIMA M, HIRABAYASHI S, YAO I, SHIRASAWA M, OSUGA J, ISHIBASHI S, FUJITA T, HATA Y
    Genes Cells 8(9) 759-768 2003年
  • Transcriptional activities of nuclear SREBP-1a, -1c, and ミ2 to different target promoters of lipogenic and cholesterogenic genes.
    J Lipid Res 43: 1220-35 2002年
  • Obesity is a critical risk factor for worsening of glucose tolerance in a family with the mutant insulin receptor.
    Diabetes Care 25: 1484-1485 2002年
  • Hyperglycemia enhances VSMC proliferation with NF-kB activation by angiotensin II and E2F-1 augmentation by growth factors.
    FUJITA N, FURUKAWA Y, DU J, ITABASHI N, FUJISAWA G, OKADA K, SAITO T, ISHIBASHI S
    Mol Cell Endocrinol 192(1-2) 75-84 2002年
  • Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells.
    Am J Physiol Heart Circ Physiol. 283:H204-12 2002年
  • An endocrinopathy characterized by dysfunction of the pituitary-adrenal axis and alopecia universalis: supporting the entity of a triple H syndrome.
    European J Endocrinol 147: 357-361. 2002年
  • Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression.
    IMAI Y, SHINDO T, MAEMURA K, SATA M, SAITO Y, KURIHARA Y, AKISHITA M, OSUGA J, ISHIBASHI S, TOBE K, MORITA H, OH-HASHI Y, SUZUKI T, MAEKAWA H, KANGAWA K, MINAMINO N, YAZAKI Y, NAGAI R, KURIHARA H
    Arterioscler Thromb Vasc Biol. 22(8) 1310-1315 2002年
  • Vasoactive intestinal peptide and cytokines enhance stem cell factor production from epidermal keratinocytes DJM-1.
    KAKURAI M, FUJITA N, KIYOSAWA T, INOUE T, ISHIBASHI S, FURUKAWA Y, DEMITSU T, NAKAGAWA H
    J Invest Dermatol 119(5) 1183-1188 2002年
  • Adrenal neutral cholesteryl ester hydrolase: identification, subcellular distribution, and sex differences.
    KRAEMER Fb, SHEN Wj, NATU V, PATEL S, OSUGA J, ISHIBASHI S, AZHAR S
    Endocrinology 143(3) 801-806 2002年
  • Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis.
    KUSAKA I, SAITO T, NAKAMURA T, NAGASAKA S, ISHIBASHI S, ISHIKAWA S
    Nephron 91(1) 167-169 2002年
  • Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha
    J Lipid Res 43:107-14 2002年
  • Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.
    J Lipid Res 43: 911-920 2002年
  • P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.
    Am J Phisiol Renal Physiol 282:F65-76 2002年
  • Pioglitazone-induced hepatic injury in a patient previously receiving troglitazone with success.
    NAGASAKA S, ABE T, KAWAKAMI A, KUSAKA I, NAKAMURA T, ISHIKAWA S, SAITO T, ISHIBASHI S
    Diabetic Med 19(4) 347-348 2002年
  • Decrease in urinary excretion of aquaporin-2 associated with impaired urinary concentrating ability in diabetic nephropathy.
    NAKAMURA T, SAITO T, KUSAKA I, HIGASHIYAMA M, NAGASAKA S, ISHIBASHI S, ISHIKAWA S
    Nephron 92(2) 445-448 2002年
  • Lipolysis in the absence of hormone-sensitive lipase: Evidence for common mechanism regulating distinct lipases.
    Diabetes 51:3368-3375 2002年
  • Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.
    OKAZAKI H, OSUGA J, TSUKAMOTO K, KITAMINE T, SHIMANO H, KIMURA S, NAGAI R, YAMADA N, ISHIBASHI S
    J Biol Chem 277(35) 31893-31899 2002年
  • The long-term effects of self-management education for patients with type 2 diabetes on glycemic control: response to Norris et al.
    Diabetes Care 25: 2115-2116 2002年
  • Effects of lifestyle modifications on patients with type 2 diabetes: The Japan diabetes complications stydy(JDCS) study design, baseline analysis and three year-interim report.
    YAMADA N, AKANUMA Y, OHASHI Y, ITO H, YAJIMA Y, YAMASHITA H, MURASE T, SAITO Y, ABE R, ISHIBASHI S, KATAGIRI A, SONE H
    Horm Metab Res 34(9) 509-515 2002年
  • HMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetes.
    ISHIBASHI S, YOSHINO G, MORISAKI N, KAWAZU S, TERAMOTO T, FUJITA T, SHIBA T, IWAMOTO Y, YAMADA N
    Life Sci. 71(20) 2403-2412 2002年
  • A kindred of familial acromegaly without evidence for linkage to MEN-1 locus.
    TAMURA Y, ISHIBASHI S, GOTODA T, YASUFUKU(TAKANO) J, TAKANO K, UEKI K, YAMASHITA S, FUJITA T, KIMURA S
    Endocrine J 49(4) 425-431 2002年
  • Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.
    YAHAGI N, SHIMANO H, HASTY A H, MATSUZAKA T, IDE T, YOSHIKAWA T, AMEMIYA‐KUDO M, ISHIBASHI S, YAMADA N
    J Biol Chem 277(22) 19353-19357 2002年
  • Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements.
    YOSHIKAWA T, SHIMANO H, YAHAGI N, IDE T, AMEMIYA‐KUDO M, MATSUZAKA T, NAKAKUKI M, TOMITA S, YAMADA N
    J Biol Chem. 277(3) 1705-1711 2002年
  • Effects of probucol on atherosclerosis of apoE-deficient or LDL receptor-deficient mice.
    YAMADA N, ISHIBASHI S, CHEN Z, SHIMANO H, YOSHIKAWA T
    Horm Metab Res 33(8) 472-479 2001年
  • Intracellular signaling mechanisms for the P-glycoprotein-induced modulation of regulatory volume increase in the mouse proximal tubule.
    Am J Physiol Renal Physiol 282:F65-F76 2001年
  • Direct effect of an acyl-CoA:cholesterol acyltransferase inhibitor, F-1394, on atherosclerosis in apolipoprotein E and low density lipoprotein receptor double knockout mice.
    CHIWATA T, ARAGANE K, FUJINAMI K, KOJIMA K, ISHIBASHI S, YAMADA N, KUSUNOKI J
    Br J Pharmacol. 133(7) 1005-1012 2001年
  • CD36 deficiency and insulin resistance.
    Lancet 358:243 2001年
  • Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.
    HASTY A H, SHIMANO H, OSUGA J, NAMATAME I, TAKAHASHI A, YAHAGI N, PERREY S, MATSUZAKA T, YAMADA N
    J Biol Chem 276(40) 37402-37408 2001年
  • A Japanese patient with lipoprotein lipase deficiency homozygous for the Gly188Glu mutation prevalent worldwide.
    YOSHIDA T, GOTODA T, OKUBO M, IIZUKA Y, ISHIBASHI S, KOJIMA T, MURAKAMI T, MURASE T, YAMADA N
    J Atheroscler Thromb 7(1) 45-49 2001年
  • Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.
    Arterioscler Thromb Vasc Biol 21:372-7 2001年
  • Lipoprotein(a) and atherosclerosis.
    Arterioscler Thromb Vasc Biol. 21:1-2 2001年
  • Asialoglycoprotein Receptor Deficiency in Mice Lacking the Major Receptor Subunit. Its obligate requirement for the stable expression of oligomeric receptor.
    TOZAWA R, ISHIBASHI S, YAMAMOTO K, OHASHI K, IIZUKA Y, SHIMANO H, KIMURA S, NAGAI R, YAMADA N
    J Biol Chem. 276(16) 12624-12628 2001年
  • The LDL receptor is the major pathway for beta-VLDL uptake by mouse peritoneal macrophages.
    PERREY S, ISHIBASHI S, KITAMINE T, OSUGA J, YAGYU H, CHEN Z, SHIONOIRI F, IIZUKA Y, YAHAGI N, TAMURA Y, OHASHI K, HARADA K, GOTODA T, YAMADA N
    Atherosclerosis 154(1) 51-60 2001年
  • Thiazolidinedione- and tumor necrosis factor alpha-induced downregulation of peroxisome proliferator-activated receptor gamma mRNA in differentiated 3T3-L1 adipocytes.
    PERREY S, ISHIBASHI S, YAHAGI N, OSUGA J, TOZAWA R, YAGYU H, OHASHI K, GOTODA T, HARADA K, CHEN Z, IIZUKA Y, SHIONOIRI F, YAMADA N
    Metabolism 50(1) 36-40 2001年
  • Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter.
    YOSHIKAWA T, SHIMANO H, AMEMIYA‐KUDO M, YAHAGI N, HASTY A H, MATSUZAKA T, OKAZAKI H, TAMURA Y, YAMADA N
    Mol Cell Biol 21(9) 2991-3000 2001年
  • Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene.
    AMEMIYA‐KUDO M, SHIMANO H, OKAZAKI H, TAMURA Y, OSUGA J, GOTODA T, SATO R, ISHIBASHI S, YAMADA N
    J Biol Chem 275(40) 31078-31085 2000年
  • Chronic inhibitory effect of insulin on plasma lipid concentrations in rats with transplanted pancreas.
    Transplantation 69:2038-42 2000年
  • Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.
    HASTY A H, SHIMANO H, PERREY S, YOSHIKAWA T, IIZUKA Y, SHIONOIRI F, OHASHI K, NAGAI R, YAMADA N
    J Biol Chem. 275(40) 31069-31077 2000年
  • Hyperthyroidism presenting as dysphagia.
    NOTO H, MITSUHASHI T, ISHIBASHI S, KIMURA S
    Intern Med 39(6) 472-473 2000年
  • Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia.
    J Lipid Res. 41:1199-204 2000年
  • Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity.
    OSUGA J, ISHIBASHI S, OKA T, YAGYU H, FUJIMOTO A, YAHAGI N, KRAEMER F B, TSUTSUMI O, YAMADA N
    Proc Natl Acad Sci U S A 97(2) 787-792 2000年
  • Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.
    YAGYU H, KAJI Y, OKA T, TAMURA Y, YAHAGI N, IIZUKA Y, YAMASHITA H, GOTODA T, ISHIBASHI S
    J Biol Chem 275(28) 21324-21330 2000年
  • Absence of Cd36 mutation in the original spontaneously hypertensive rats with insulin resistance.
    Yamada N., Gotoda T., Kato N., Iizuka Y., Bihoreau M.-T., Osuga J.-I., Yamori Y., Murakami T., Ishibashi S., Shimano H.
    Nat Genet 22(3) 226-228 1999年
  • Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.
    SHIMANO H, YAHAGI N, HASTY A H, TAMURA Y, IIZUKA Y, OHASHI K, HARADA K, GOTODA T, YAMADA N
    J Biol Chem 274(50) 35832-35839 1999年
  • Embryonic lethality and defective neural tube closure in mice lacking squalene synthase.
    TOZAWA R, ISHIBASHI S, OSUGA J, CHEN Z, OHASHI K, YAHAGI N, HARADA K, GOTODA T, YAMADA N
    J Biol Chem 274(43) 30843-30848 1999年
  • Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice.
    J Lipid Res 40:1677-85 1999年
  • A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.
    YAHAGI N, SHIMANO H, HASTY A H, OKAZAKI H, OHASHI K, OSUGA J, NAGAI R, ISHIBASHI S, YAMADA N
    J Biol Chem 274(50) 35840-35844 1999年
  • Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice.
    YUAN X, ISHIBASHI S, HARUYAMA T, WATANABE Y, IWATA H, IIDA M, SUGIMURA H, YAMADA N, ISHIKAWA F
    Genes Cells 4(10) 563-572 1999年
  • Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.
    J Clin Invest 101:1784-8 1998年
  • Lipoprotein(a) as a coronary risk factor in Japanese patients with Type II (non-insulin-dependent) diabetes mellitus. Relation with apolipoprotein(a) phenotypes.
    MURAKAMI K, ISHIBASHI S, YOSHIDA Y, YAMADA N, AKANUMA Y
    Diabetologia 41(11) 1397-1398 1998年
  • A truncated species of apolipoprotein B (B-38.7) in a patient with homozygous hypobetalipoproteinemia associated with diabetes mellitus.
    Arterioscler Thromb Vasc Biol 18:1330-4 1998年
  • Improved glycemic control in a diabetic patient after discontinuation of allopurinol administration.
    Diabetes Care 21:192-3 1998年
  • Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.
    J Clin Invest 102:386-94 1998年
  • Role of macrophage scavenger receptors in diet-induced atherosclerosis in mice.
    Lab Invest 78:423-34 1998年
  • Clinical features associated with the homozygous Trp64Arg mutation of the beta3-adrenergic receptor: no evidence for its association with obesity in Japanese.
    Arterioscler Thromb Vasc Biol 18:941-6 1998年
  • Skipping of exon 14 and possible instability of both the mRNA and the resultant truncated protein underlie a common cholesteryl ester transfer protein deficiency in Japan.
    Arterioscler Thromb Vasc Biol 17:1376-81 1997年
  • Apoptotic cell death in atherosclerotic plaques of hyperlipidemic knockout mice.
    HARADA K, CHEN Z, ISHIBASHI S, OSUGA J, YAGYU H, OHASHI K, YAHAGI N, SHIONOIRI F, SUN Lm, YAZAKI Y, YAMADA N
    Atherosclerosis 135(2) 235-239 1997年
  • Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway.
    HARADA K, ISHIBASHI S, MIYASHITA T, OSUGA J, YAGYU H, OHASHI K, YAZAKI Y, YAMADA N
    FEBS Lett. 411(1) 63-66 1997年
  • Suppression of neutral cholesterol ester hydrolase activity by antisense DNA of hormone-sensitive lipase.
    OSUGA J, ISHIBASHI S, SHIMANO H, INABA T, KAWAMURA M, YAZAKI Y, YAMADA N
    Biochem Biophys Res Commun 233(3) 655-657 1997年
  • Effects of apo E deficiency on plasma lipid levels in mice lacking APOBEC-1.
    OSUGA J, YAGYU H, OHASHI K, HARADA K, YAZAKI Y, YAMADA N, ISHIBASHI S
    Biochem Biophys Res Commun. 236(2) 375-378 1997年
  • A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection.
    SUZUKI H, KURIHARA Y, KATAOKA M, HIGASHI T, DOI T, VAN BERKEL T J C, STEINBRECHER U P, MAEDA N, KODAMA T
    Nature 386(6622) 292-296 1997年
  • The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit.
    BRAUN J R, WILLNOW T E, ISHIBASHI S, ASHWELL G, HERZ J
    J Biol Chem 271(35) 21160-21166 1996年
  • Transgenic mouse and gene therapy.
    Diabetes Suppl 3:S129-32 1996年
  • Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: a mechanism for phenotypic change tophagocytic cells.
    Mol Cell Biol 16:2264-73 1996年
  • Enhanced expression of platelet-derived growth factor-beta receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angiopathy.
    Diabetes 45:507-12 1996年
  • Synergistic effects of transforming growth factor-beta on the expression of c-fms, macrophage colony-stimulating factor receptor gene, in vascular smooth muscle cells.
    INABA T, ISHIBASHI S, HARADA K, OSUGA J, YAGYU H, OHASHI K, YAZAKI Y, YAMADA N
    FEBS Lett 399(3) 207-210 1996年
  • Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both.
    ISHIBASHI S, PERREY S, CHEN Z, OSUGA J, SHIMADA M, OHASHI K, HARADA K, YAZAKI Y, YAMADA N
    J Biol Chem 271(37) 22422-22427 1996年
  • Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.
    ISHIBASHI S, SCHWARZ M, FRYKMAN P K, HERZ J, RUSSELL D W
    J Biol Chem 271(30) 18017-18023 1996年
  • Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.
    SHIMADA M, ISHIBASHI S, INABA T, YAGYU H, HARADA K, OSUGA J, OHASHI K, YAZAKI Y, YAMADA N
    Proc Natl Acad Sci U S A 93(14) 7242-7246 1996年
  • Sick sinus syndrome in association with malignant lymphoma.
    Eur Heart J 17:968 1996年
  • Rapid genotyping of low density lipoprotein receptor knockout mice using a polymerase chain reaction technique.
    Lab Anim 29:447-9 1995年
  • Induction of sustained expression of proto-oncogene c-fms by platelet-derived growth factor, epidermal growth factor, and basic fibroblast growth factor, and its suppression by interferon-gamma and macrophage colony-stimulating factor in human aortic m・・・
    J Clin Invest 95:1133-9 1995年
  • Cloning and structural analysis of the mouse apolipoprotein B mRNA editing protein gene.
    OSUGA J, INABA T, HARADA K, YAGYU H, SHIMADA M, YAZAKI Y, YAMADA N, ISHIBASHI S
    Biochem Biophys Res Commun 214(2) 653-662 1995年
  • Overexpression of human lipoprotein lipase protects diabetic transgenic mice from diabetic hypertriglyceridemia and hypercholesterolemia.
    Arterioscler Thromb Vasc Biol 15:1688-94 1995年
  • Overexpression of human lipoprotein lipase increases hormone-sensitive lipase activity in adipose tissue of mice.
    SHIMADA M, ISHIBASHI S, YAMAMOTO K, KAWAMURA M, GOTODA T, HARADA K, OHSUGA J, YAZAKI Y, YAMADA N
    Biochem Biophys Res Commun 211(3) 761-766 1995年
  • Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.
    J Clin Invest 93:1885-93 1994年
  • Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit.
    J Biol Chem 269:27803-6 1994年
  • The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.
    ISHIBASHI S, HERZ J, MAEDA N, GOLDSTEIN J L, BROWN M S
    Proc Natl Acad Sci U S A. 91(10) 4431-4435 1994年
  • Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist
    WILLNOW T E, SHENG Z, ISHIBASHI S, HERZ J
    Science 264(5164) 1471-1474 1994年
  • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.
    J Clin Invest 92:883-93 1993年
  • Apolipoprotein E metabolism in sciatic nerves of diabetic rats. Implication for diabetic neuropathy.
    Horm Metab Res 2:82-7 1993年
  • Apolipoprotein E polymorphism is associated with plasma cholesterol response in a 7-day hospitalization study for metabolic and dietary control in NIDDM.
    Diabetes Care 16:564-9 1993年
  • Role of monocyte colony-stimulating factor in foam cell generation.
    Proc Soc Exp Biol Med 200:240-4 1992年
  • Heterogeneous mutations in the human lipoprotein lipase gene in patients with familial lipoprotein lipase deficiency.
    J Clin Invest 88:1856-64 1991年
  • Occurrence of multiple aberrantly spliced mRNAs upon a donor splice site mutation that causes familial lipoprotein lipase deficiency.
    J Biol Chem 266:24757-62 1991年
  • Overexpression of low density lipoprotein receptor on Chinese hamster ovary cells generates foam cells.
    Arterioscler Thromb. 11:1310-4 1991年
  • The enhanced cellular uptake of very-low-density lipoprotein enriched in apolipoprotein E.
    Biochim Biophys Acta 1082:63-70 1991年
  • Effects of human recombinant macrophage colony-stimulating factor on the secretion of lipoprotein lipase from macrophages.
    Arterioscler Thromb 11:1315-21 1991年
  • Oxidation-labile subfraction of human plasma low density lipoprotein isolated by ion-exchange chromatography.
    J Lipid Res 32:763-73 1991年
  • Characterization of monoclonal anti-rabbit apolipoprotein E antibodies and chemical composition of lipoproteins separated by anti-apolipoprotein E immuno-affinity chromatography.
    J Biochem (Tokyo) 109:204-10 1991年
  • Effect of tumor necrosis factor/cachectin on the activity of the low density lipoprotein receptor on human skin fibroblasts.
    HARADA K, SHIMANO H, KAWAKAMI M, ISHIBASHI S, GOTODA T, MORI N, TAKAKU F, YAMADA N
    Biochem Biophys Res Commun 172(3) 1022-1027 1990年
  • Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte-derived macrophages.
    J Biol Chem 265:14109-17 1990年
  • Apolipoprotein E and lipoprotein lipase secreted from human monocyte-derived macrophages modulate very low density lipoprotein uptake.
    J Biol Chem 265:3040-7 1990年
  • Effect of exogenous apo E on the cellular binding of lipoproteins.
    Gerontology 36 Suppl 1:42-8 1990年
  • Cholesterol-free diet with a high ratio of polyunsaturated to saturated fatty acids in heterozygous familial hypercholesterolemia: significant lowering effect on plasma cholesterol.
    MOKUNO H, YAMADA N, SUGIMOTO T, KOBAYASHI T, ISHIBASHI S, SHIMANO H, TAKIZAWA M, TAKAKU F, MURASE T
    Horm Metab Res. 22(4) 246-251 1990年
  • Human monocyte colony-stimulating factor enhances the clearance of lipoproteins containing apolipoprotein B-100 via both low density lipoprotein receptor-dependent and -independent pathways in rabbits.
    J Biol Chem 265:12869-75 1990年
  • Plasma cholesterol-lowering activity of monocyte colony-stimulating factor (M-CSF).
    Ann N Y Acad Sci 587:362-70 1990年
  • Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors.
    YOKODE M, HAMMER R E, ISHIBASHI S, BROWN M S, GOLDSTEIN J L
    Science 250(4985) 1273-1275 1990年
  • The release of hepatic triglyceride lipase from rat monolayered hepatocytes in primary culture.
    YOON T H, YAMADA N, ISHIBASHI S, SHIMANO H, GOTODA T, HARADA K, AKANUMA Y, MURASE T, TAKAKU F
    Endocrinol Jpn 37(3) 437-442 1990年
  • Enhanced lipoprotein lipase secretion from human monocyte-derived macrophages caused by hypertriglyceridemic very low density lipoproteins.
    Arteriosclerosis 9:650-5 1989年
  • Composition of very-low-density lipoproteins in non-insulin-dependent diabetes mellitus.
    Clin Chem 35:808-12 1989年
  • A neonatal case of apolipoprotein C-II deficiency.
    Eur J Pediatr 148:550-2 1989年
  • Plasma apolipoproteins in patients with multi-infarct dementia.
    Atherosclerosis 79:257-60 1989年
  • Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits.
    Proc Natl Acad Sci U S A 86:665-9 1989年
  • Enhanced synthesis and secretion of apolipoprotein E from sciatic nerves of streptozotocin-induced diabetic rats after injury.
    ISHIBASHI S, YAMADA N, OKA Y, SHIMANO H, MORI N, YOON T H, AKANUMA Y, MURASE T, TAKAKU F
    Biochem Biophys Res Commun 155(1) 283-288 1988年
  • High-cholesterol diet-induced lipoproteins stimulate lipoprotein lipase secretion in cultured rat alveolar macrophages.
    Biochim Biophys Acta 922:103-10 1987年
  • Down-regulation of hepatic LDL receptor protein and messenger RNA in fasted rabbits.
    J Biochem (Tokyo) 104:712-6 1988年
  • Sick sinus syndrome in malignant lymphoma involving the heart.
    石橋俊, 湯尾明, 永井良三, 大内尉義, 今鷹耕二, 矢崎義雄, 高久史麿, 岡輝明
    Nippon Naika Gakkai Zasshi 76(1) 100-105 1987年
  • Human recombinant TNF suppresses lipoprotein lipase activity and stimulates lipolysis in 3T3-L1 cells.
    J Biochem (Tokyo) 101:331-8 1987年
  • Lipoprotein lipase in mouse peritoneal macrophages: the effects of insulin and dexamethasone.
    J Biochem (Tokyo) 100:1373-8 1986年
  • Human recombinant TNF suppresses lipoprotein lipase activity and stimulates lipolysis in 3T3-L1 cells.
    J Biochem (Tokyo) 101:331-8 1987年
  • Plasma apolipoprotein CII levels in hypertriglyceridemia
    Metabolism 35:781-5 1986年
  • Immunohistochemical localization of apolipoprotein E in atherosclerotic lesions of the aorta and coronary arteries.
    Atherosclerosis 60:1-6 1986年
  • Hyperlipidaemia in patients with hypopituitarism.
    Acta Endocrinol (Copenh) 110:456-60 1985年
  • A platelet factor stimulating the proliferation of vascular endothelial cells. Partial purification and characterization.
    MIYAZONO K, OKABE T, ISHIBASHI S, URABE A, TAKAKU F
    Exp Cell Res 159(2) 487-494 1985年
  • A case of polymyositis associated with hypertriglyceridemia due to decline of lipoprotein lipase activity.
    Nippon Naika Gakkai Zasshi 73:368-73 1984年


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