岡田 成生 (オカダ ナルオ)

  • 歯科口腔外科学講座 助教
Last Updated :2022/06/02



  • 医学博士(自治医科大学)


J-Global ID


  • 口腔癌   fMRI   リハビリテーション   


  • ライフサイエンス / 外科系歯学


  • 2002年04月 - 2003年03月  自治医科大学医学部研究生



  • N. Okada, K. Sasaguri, T. Otsuka, A. Fujita, H. Ito, T. Noguchi, Y. Jinbu, M. Kusama
    The present study aimed to verify the importance of postoperative articulatory rehabilitation in patients with oral cancer and to clarify the neurological changes underlying articulatory functional recovery. A longitudinal assessment of oral function and accompanying brain activity was performed using non-invasive functional magnetic resonance imaging (fMRI). We assessed 13 patients with cancers of the tongue and oral floor before and after ablative surgery. Articulatory function was assessed preoperatively and postoperatively using a conversation intelligibility test and the Assessment of Motor Speech for Dysarthria test. Patients also performed a verbal task during fMRI scans. The assessments were then repeated after the patients had undergone 4-6 months of articulatory rehabilitation therapy. Compared to pretreatment levels, articulatory rehabilitation resulted in a significant increase in activation in the supplementary motor cortex, thalamus, and cingulate cortex. The present study offers a quantitative assessment of the effects of speech rehabilitation by investigating changes in brain activation sites.
  • T. Otsuka, H. Dan, I. Dan, M. Sase, T. Sano, D. Tsuzuki, A. Fujita, K. Sasaguri, N. Okada, M. Kusama, Y. Jinbu, E. Watanabe
    JOURNAL OF DENTAL RESEARCH 91 12 1196 - 1201 2012年12月 [査読有り][通常論文]
    For objective neurophysiological evaluation of the function of the trigeminal system, magnetoencephalography-based TSEF (trigeminal somatosensory-evoked field) assessment would be valuable in providing spatial and temporal profiles of cortical responses. However, this necessitates knowledge of how TSEF varies with trigeminal nerve dysfunctions. We introduced a conduction block of the trigeminal nerve using local anesthesia (lidocaine) to temporally mimic nerve dysfunctions, and monitored TSEF changes. Following an electrical stimulation of the lower lip, a magnetic response with peak latency of approximately 20 ms was identified in all participants. Dipole for the peak was estimated on the post-central gyrus in the participant's own magnetic resonance image. After normalization to Montreal Neurological Institute (MNI) space and inter-participant data integration, the summary equivalent current dipole localization among participants remained in the post-central gyrus, suggesting validity of the use of MNI space. Partial anesthesia of the lower lip led to a loss of the waveform characteristics of TSEF for electrical stimulation to the trigeminal nerve. We verified that the 20-ms latency cortical response of TSEF components localized at the primary sensory cortex can serve as a robust neurofunctional marker of experimental trigeminal nerve dysfunction.
  • 岡田 成生, 上野 泰宏, 星 健太郎, 伊藤 弘人, 神部 芳則, 草間 幹夫, 小林 馨
    歯科放射線 48 1 8 - 11 2009年03月 [査読有り][通常論文]
  • 中山 竜司, 星 健太郎, 岡田 成生, 篠崎 泰久, 神部 芳則, 草間 幹夫
    日本口腔外科学会雑誌 55 1 22 - 24 日本口腔外科学会 2009年01月 [査読有り][通常論文]
    Myofibroma is a rare benign proliferation of fibroblastic tissue occurring exclusively in infants and children. Myofibroma rarely arises in the oral and maxillofacial region. We report a case of a myofibroma-like tumor arising in the tongue of a 50-year-old man. He had noticed gradual swelling of the right side of the tongue. Two weeks later he was referred to our hospital for treatment. A soft elastic mass arising in the right margin of the tongue, measuring 10 ×10 ×12 mm, was recognized. Surgical resection of the tumor was performed with the patient under local anesthesia. Immunohistochemical staining was very useful for establishing the diagnosis of a myofibroma-like tumor. This tumor was positive for vimentin and HHF-35 and negative for desimin. The patient has shown no signs of recurrence during 1 year of follow-up.
  • 上野 泰宏, 神部 芳則, 山下 雅子, 岡田 成生, 草間 幹夫, 槻木 恵一
    日本口腔粘膜学会雑誌 = Journal of Japanese Society for Oral Mucous Membrane 12 2 67 - 70 2006年12月 [査読有り][通常論文]


  • 篠崎 泰久, 笹栗 健一, 高橋 淳, 岡田 成生, 上野 泰宏, 宮城 徳人, 早坂 純一, 池田 薫, 星 健太郎, 神部 芳則, 草間 幹夫 自治医科大学紀要 30 67 -72 2007年12月 [査読無し][通常論文]
    永久歯の萌出不全を主訴に,近歯科医院より自治医科大学附属病院歯科口腔外科に紹介受診し,小矯正(MTM)を施行した13例について臨床的に検討し,代表的な2症例を供覧する。症例1は,乳歯の晩期残存による上顎中切歯の埋伏症例で,MTMの施行により審美的および機能的な萌出誘導が可能であった。 症例2は,歯牙腫により右側上顎犬歯および第一小臼歯の埋伏を認めた症例で,歯牙腫摘出術施行1年後に再度歯肉を剥離し矯正装置を埋伏歯に装着しMTMを施行した。その結果,埋伏歯2歯は歯列内へ萌出誘導された。MTMは,萌出不全による埋伏永久歯に対し有効な手段であり,当科で施行した全症例で審美的および機能的に良好な結果を得た。


  • 文部科学省:科学研究費補助金(若手研究(B))
    研究期間 : 2010年 -2012年 
    代表者 : 岡田 成生

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