研究者総覧

岡崎 仁昭 (オカザキ ヒトアキ)

  • 医学教育センター 教授
Last Updated :2022/01/25

研究者情報

学位

  • 博士(医学)(自治医科大学(JMU))

ホームページURL

J-Global ID

研究キーワード

  • 医学教育学   総合診療   臨床免疫学   アレルギ-膠原病学   Medical Education   Clinical Immunology   Allergology & Rheumatology   

研究分野

  • ライフサイエンス / 膠原病、アレルギー内科学
  • ライフサイエンス / 内科学一般
  • ライフサイエンス / 免疫学

学歴

  •         - 1992年   自治医科大学(JMU)   医学研究科   結合織疾患
  •         - 1992年   自治医科大学   Graduate School, Division of Medicine
  •         - 1984年   自治医科大学(JMU)   医学部
  •         - 1984年   自治医科大学   Faculty of Medicine

所属学協会

  • American College of Physiclans(ACP)   日本内科専門医会   アメリカリウマチ学会   日本臨床免疫学会   日本リウマチ学会   日本アレルギ-学会   日本免疫学会   日本内科学会   

研究活動情報

書籍

  • リウマチ、膠原病(共著)
    ()
    疾患からみた臨床薬理学 薬業時報社 1999年

MISC

  • N Umemoto, M Kakurai, H Okazaki, T Kiyosawa, T Demitsu, H Nakagawa JOURNAL OF DERMATOLOGICAL SCIENCE 31 (2) 161 -164 2003年04月 [査読無し][通常論文]
     
    Vasoactive intestinal peptide (VIP) has been suggested to play some roles in atopic dermatitis. Tissue of VIP levels has been reported to increase in chronic lichenified lesions of atopic dermatitis (AD). To analyze whether serum levels of VIP in AD patients are elevated compared with normal controls and correlated with the disease severity, we measured serum levels of VIP using enzyme-linked immunosorbent assay in 53 patients with AD and 21 healthy individuals. The results showed that serum levels of VIP in AD patients (345.8 +/- 71.5 mug/ml) were significantly higher than those in healthy individuals (307.1 +/- 42.6 mug/ml). However, a correlation was not found between serum VIP levels and disease severity, other markers including serum LDH levels, total serum IgE levels, and peripheral blood eosinophil counts in patients with AD. This indicates that VIP levels in AD patients were elevated not only in the skin but also in the serum, suggesting that increased serum VIP levels in the patients with AD might be involved in its pathogenesis. (C) 2003 Elsevier Science Ireland Ltd. and the Japanese Society of Investigative Dermatology. All rights reserved.
  • N Umemoto, M Kakurai, H Okazaki, T Kiyosawa, T Demitsu, H Nakagawa JOURNAL OF DERMATOLOGICAL SCIENCE 31 (2) 161 -164 2003年04月 [査読無し][通常論文]
     
    Vasoactive intestinal peptide (VIP) has been suggested to play some roles in atopic dermatitis. Tissue of VIP levels has been reported to increase in chronic lichenified lesions of atopic dermatitis (AD). To analyze whether serum levels of VIP in AD patients are elevated compared with normal controls and correlated with the disease severity, we measured serum levels of VIP using enzyme-linked immunosorbent assay in 53 patients with AD and 21 healthy individuals. The results showed that serum levels of VIP in AD patients (345.8 +/- 71.5 mug/ml) were significantly higher than those in healthy individuals (307.1 +/- 42.6 mug/ml). However, a correlation was not found between serum VIP levels and disease severity, other markers including serum LDH levels, total serum IgE levels, and peripheral blood eosinophil counts in patients with AD. This indicates that VIP levels in AD patients were elevated not only in the skin but also in the serum, suggesting that increased serum VIP levels in the patients with AD might be involved in its pathogenesis. (C) 2003 Elsevier Science Ireland Ltd. and the Japanese Society of Investigative Dermatology. All rights reserved.
  • アレルギー・リウマチ・膠原病における免疫抑制剤の使い方
    内科専門医会誌 15, 254-259 2003年 [査読無し][通常論文]
  • Ann Rheum Dis 61, 761-762 2002年 [査読無し][通常論文]
  • Characterization of chemokire receptor expression and eytokire production in ciroulstirg CD4+T cells from patients with atopic dermatits
    Clin Exp Allergy 32, 1236-1242 2002年 [査読無し][通常論文]
  • Effects of FTY720 in MRL-lpr/lpr Mice:Therapeutic Protential in Systemic Lupus Erythematosus
    J Rheumato 1 29, 707-716 2002年 [査読無し][通常論文]
  • 免疫抑制剤(FTY720)
    臨床免疫 38[Suppl. 20], 67-72 2002年 [査読無し][通常論文]
  • 老人病と補体
    六法出版 老人病診療Q & A 38 1034 -1037 2002年 [査読無し][通常論文]
  • スタチンの免疫抑制作用
    最新医学社 57(6), 125-128 2002年 [査読無し][通常論文]
  • Ann Rheum Dis 61, 761-762 2002年 [査読無し][通常論文]
  • Characterization of chemokire receptor expression and eytokire production in ciroulstirg CD4+T cells from patients with atopic dermatitis
    Clin Exp Allergy 32, 1236-1242 2002年 [査読無し][通常論文]
  • Effects of FTY720 in MRL-lpr/lpr Mice:Therapeutic Protential in Systemic Lupus Erythematosus
    J Rheumato 1 29, 707-716 2002年 [査読無し][通常論文]
  • K Kuroiwa, T Arai, H Okazaki, S Minota, S Tominaga BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 284 (5) 1104 -1108 2001年06月 [査読無し][通常論文]
     
    Soluble human ST2 protein (IL1RL1-a) in the sera of patients with various autoimmune diseases was identified by a newly developed procedure using specific monoclonal antibodies. After immunoprecipitation and subsequent immunoblotting, a glycosylated protein of about 60 kDa was detected in the sera of SLE patients, but not in the sera of healthy controls. The experiments using gel filtration and SDS-PAG;E under a nonreducing condition indicated the existence of the ST2 multimer in serum. The mobility of the natural protein was slower than that of the recombinant human ST2 protein produced by COS7 cells in SDS-PAGE, suggesting a difference of glycosylation between humans and monkeys. The identification of the natural human ST2 protein should be important both to fundamental researches and the further clarification of the clinical implications of the ST2 protein. (C) 2001 Academic Press.
  • 発熱と頭痛とを呈し、精査加療目的で入院した30歳の男性
    内科専門医会誌 12 (4) 674 -690 2000年 [査読無し][通常論文]
  • くも膜下出血と全身性エリテマトーデス
    ループス 9 521 -526 2000年 [査読無し][通常論文]
  • わずか2年の経過で続発性アミロイドーシスを来したスティル病の1症例
    リウマチ 40 (3) 633 -638 2000年 [査読無し][通常論文]
  • T細胞補助受容体分子ICOSの同定とその意義
    臨床免疫 33 (1) 119 2000年 [査読無し][通常論文]
  • Drclofenac-induced aseptic meningitis
    12 (4) 674 -690 2000年 [査読無し][通常論文]
  • A Mimori, T Suzuki, M Hashimoto, H Nara, T Yoshio, JI Masuyama, H Okazaki, D Hirata, S Kano, S Minota LUPUS 9 (7) 521 -526 2000年 [査読無し][通常論文]
     
    The frequency, clinical profile, treatment and outcome of subarachnoid hemorrhage (SAH) in patients with systemic lupus erythematosus (SLE) were assessed retrospectively, based on the case records of SLE of the Jichi Medical School Hospital over a 20 year period. Clinically defined SAH was found in 10 (3.9%) out of 258 SLE patients, which represented a frequency higher than previously assumed. Five patients had active SLE and lacked an apparent cause of SAH, other than SLE. A high mortality rate (5/5), no visible aneurysm on angiogram (3/4), and an onset during intractable SLE or after discontinued or no steroid therapy because of medical noncompliance (4/5) were characteristic of patients with active SLE, and thus an earlier successful suppression of SLE, if possible, might have plt vented their SAH. In contrast, in the 5 patients with inactive SLE, 2 out of 3 saccular aneurysms were succcessfuly clipped and small bleeding of one patient without aneurysms remitted spontaneously without the need for additional steroid therapy. When one death, which occurred outside of medical care, was excluded, the survival ratio of the hospitalized SAH patients with inactive SLE was significantly better than that with active SLE (3/4 versus 0/5, P = 0.0476). In conclusion, the relatively common occurence of SAH in SLE patients, and a significantly different clinical impact of SAH in respect to active and inactive SLE, were suggested from the results.
  • Rapidly Progressed Secondary Amyloidosis in a Patient with Still's Disease with α-allele in His SAA1 Gene
    Rhiemachi 40 (3) 633 -638 2000年 [査読無し][通常論文]
  • In vitro and in vivo inhibition of activation induced T cell apoptosis by bucillamine.
    J. Rheumatol 27 (6) 1358 2000年 [査読無し][通常論文]
  • ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.
    33 (1) 119 2000年 [査読無し][通常論文]
  • Sj(]E88D8[)gren症候群に伴う髄膜炎,髄膜脳炎
    神経内科 51 140 1999年 [査読無し][通常論文]
  • Weber-Christian病
    外来診療のすべて(改訂第2版)Medical View 804 -805 1999年 [査読無し][通常論文]
  • 体温の上昇(高体温と発熱)
    外来診療のすべて(改訂第2版)Medical View 46 -49 1999年 [査読無し][通常論文]
  • 副刺激ブロックによる全身性エリテマトーデスの治療
    内科 83 123 -126 1999年 [査読無し][通常論文]
  • Meningitis(meningoencephalitis) in sj(]E88D8[)gren syndrone
    51 140 1999年 [査読無し][通常論文]
  • Early diagnosis of Takayasu arteritis using gadolinium-enhanced magnetic resonance
    Arthritis & Rheunotism 42 (7) 1549 1999年 [査読無し][通常論文]
  • Infection with an Unenvelaped DNA virus(TTV)Associated with Non A to G Hepatitis in Patients With Rheumatoid Arthritis
    British Journal of Rheumatology 37 (12) 1361 1998年 [査読無し][通常論文]
  • Therapeutic effects of C2-ceramide and FTY720 on the clinical course of MRL-lpr/lpr mice.
    Arthritis. Rheum. (41) S175 1998年 [査読無し][通常論文]
  • Nucleolin as one of the earliest targets of autoantibodies produced in NZB/W F1 and NRL/lpr lupus-prone mice.
    Arthritis. Rheum. (41) S254 1998年 [査読無し][通常論文]
  • Correlation of serum IgG artibodies to recombinant PO fusion protein with IgG antibodies to carboxylterminal 22 synthetic peptides and carboxyl-terminal 22 amino acid-deleted recombinant PO fusion protein in patients with ststemic lupus erythematosus
    Arthritis Rheum. (40) 1364 1997年 [査読無し][通常論文]
  • J. Exp. Med. 181 (6) 2201 -2211 1995年 [査読無し][通常論文]
  • 肺高血圧症を伴ったSLEの1剖検例。
    33 540 1994年 [査読無し][通常論文]
  • Masaki SATO, Hitoaki OKAZAKI, Hiroshi OKAMOTO, Akihiko OHTAKA, Hideo SHIMIZU, Nagahiro MINATO, Shogo KANO Jpn. J. Med 33 (9) 540 -542 1994年 [査読無し][通常論文]
  • CD3+4-8-αβ cell population with biased T-cell receptor Vβ gene usage. Presence in bone marrow and possible involvement of IL-3 for their extrathymic development
    J. Immunol. 149 1143 1992年 [査読無し][通常論文]
  • Yasuki Ogawa, Hitoaki Okazaki, Tetsuo Sudo, Noriko Ohno, Masayo Itoh, Masakazu Hattori, Masahiko Lizuka, Nagahiro Minato International Immunology 3 (1) 39 -47 1991年01月 [査読無し][通常論文]
     
    Interleukin 2 (IL-2)-dependent granular T lymphocyte (GTL) lines derived from murlne spleen were shown to express a Ly-5 antigen with the so-called 'B220-epltope' recognized by 6B2 mAbs, which were normally exhibited on B-lineage cells. Immunoprecipitatlon analysis revealed that the Ly-5 isoform on GTL lines represented the highest-molecular-weight Ly-5 so far described (260 kd), distinct from the B220 isoform on a pre-B cell line (240 kd). The size difference between them was also evident after the endoglycosidase treatment (210 versus 190 kd), strongly suggesting that these Ly-5 isoforms had core proteins of distinct size. Sequential immunoprecipitation by 6B2 and 14.8 mAbs further indicated that the 260 kd Ly-5 on GTL lines predominantly expressed '6B2 epitope' while '14.8 epitope' dominated In the B220 (240 kd) on a pre-B cell line. Northern blot analysis of the Ly-5 transcripts using probes for the known alternative exons failed to show any evidence for mRNA of the 260 kd Ly-5 distinct from that of B220. Polymerase chain reaction analysis, however, suggested that the 260 kd Isoform mRNA might be transcribed from a distinct promoter with a yet undefined exon(s). The 6B2+ Ly-5 isoform was hardly detected on normal splenic T cells, but was shown to be induced rapidly on the majority of T cells following IL-2 stimulation in vitro, indicating that this particular Ly-5 isoform behaved as an 'activation antigen' on T cells. In contrast, splenic B cells constitutively expressed 6B2+ Ly-5, although the mol. wt was quite different between the primary B cells and LPS-activated B cells. The unique nature of the 6B2 epitope expressed on the selected Ly-5 isoforms is also discussed. © 1991 Oxford University Press.
  • M HATTORI, H OKAZAKI, Y ISHIDA, M ONUMA, S KANO, T HONJO, N MINATO JOURNAL OF IMMUNOLOGY 144 (10) 3809 -3815 1990年05月 [査読無し][通常論文]
  • Effect of various interleukins on human B cell activation : Analysis of inhibitory action of IL-4
    Allergy & Immunology 9 165 1990年 [査読無し][通常論文]
  • Identification and gene cloning of a new phosphatidylirositol-linked antigen expressed on mature lymphocytes
    J. Immunol 145 3924 1990年 [査読無し][通常論文]
  • DNA and Cell Biology 9 (3) 213 -220 1990年 [査読無し][通常論文]
  • Natural killer cell activity in workers exposed to benzidine and B-naphthylamine.
    Brit. J. Indust. Med. 42 338 1990年 [査読無し][通常論文]
  • Interleukin-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing αβ or γδ T cell receptors in vitro. Synergism with interleukin 2.
    J. Immunol 143 2917 1989年 [査読無し][通常論文]
  • 皮膚血管炎(過敏性血管炎)
    神経症候群(]G0004[)(臨域別症候群シリーズ No.29) 29 310 [査読無し][通常論文]
  • Cutaneous leukocytoclastic angiitis(hypersensitivity vasculitis)
    29 310 [査読無し][通常論文]

共同研究・競争的資金等の研究課題

  • 医学教育と試験・評価
    研究期間 : 2009年 -2011年
  • Introduction of SEQ into medical examination
    研究期間 : 2009年 -2011年
  • Th1/Th2バランスと自己免疫疾患
  • アポトーシスの異常と自己免疫疾患
  • T細胞の分化・増殖に関する研究
  • Th1/Th2 Balance in Autoimmune Diseases
  • Apoptotic Defects and Autoimmune Diseases
  • Study on T cell differentiation and proliferation

委員歴

  • 日本内科専門医会   評議員   日本内科専門医会
  • 日本臨床免疫学会   評議員   日本臨床免疫学会
  • 日本アレルギ-学会   評議員   日本アレルギ-学会


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