研究者総覧

亀井 潤 (カメイ ジュン)

  • 泌尿器科 講師
Last Updated :2022/08/28

研究者情報

ホームページURL

J-Global ID

研究分野

  • ライフサイエンス / 泌尿器科学

研究活動情報

論文

  • Satoru Taguchi, Taketo Kawai, Tohru Nakagawa, Jimpei Miyakawa, Kenjiro Kishitani, Kazuma Sugimoto, Yu Nakamura, Jun Kamei, Daisuke Obinata, Kenya Yamaguchi, Tomoyuki Kaneko, Kanae Yoshida, Sachi Yamamoto, Shigenori Kakutani, Koichiro Kanazawa, Yuriko Sugihara, Mayuko Tokunaga, Akihiko Matsumoto, Yukari Uemura, Yoshiyuki Akiyama, Yuta Yamada, Yusuke Sato, Daisuke Yamada, Yutaka Enomoto, Hiroaki Nishimatsu, Akira Ishikawa, Yoshinori Tanaka, Yasushi Nagase, Tetsuya Fujimura, Hiroshi Fukuhara, Satoru Takahashi, Haruki Kume
    International journal of urology : official journal of the Japanese Urological Association 2022年08月 
    OBJECTIVES: Although the treatment strategy for advanced urothelial carcinoma (aUC) has drastically changed since pembrolizumab was introduced in 2017, studies revealing current survival rates in aUC are lacking. This study aimed to assess (1) the improvement in survival among real-world patients with aUC after the introduction of pembrolizumab and (2) the direct survival-prolonging effect of pembrolizumab. METHODS: This multicenter retrospective study included 531 patients with aUC undergoing salvage chemotherapy, including 200 patients treated in the pre-pembrolizumab era (2003-2011; earlier era) and 331 patients treated in a recent 5-year period (2016-2020; recent era). Using propensity score matching (PSM), cancer-specific survival (CSS) and overall survival (OS) were compared between the earlier and recent eras, in addition to between the recent era, both with and without pembrolizumab use, and the earlier era. RESULTS: After PSM, the recent era cohort had significantly longer CSS (21 months) and OS (19 months) than the earlier era cohort (CSS and OS: 12 months). In secondary analyses using PSM, patients treated with pembrolizumab had significantly longer CSS (25 months) and OS (24 months) than those in the earlier era cohort (CSS and OS: 11 months), whereas patients who did not receive pembrolizumab in the recent era had similar outcomes (CSS and OS: 14 months) as the earlier era cohort (CSS and OS: 12 months). CONCLUSIONS: Patients with aUC treated in the recent era exhibited significantly longer survival than those treated before the introduction of pembrolizumab. The improved survival was primarily attributable to the use of pembrolizumab.
  • Jun Kamei, Hirotaka Yokoyama, Toshiro Niki, Ryosuke Suda, Toru Sugihara, Akira Fujisaki, Satoshi Ando, Daiki Iwami, Tetsuya Fujimura
    IJU case reports 5 3 199 - 202 2022年05月 
    Introduction: We present a case of urothelial carcinoma in a renal allograft successfully treated with pembrolizumab. Case presentation: A 39-year-old woman presented with nausea and anorexia 9 years after a renal transplantation. Positron emission tomography revealed a neoplasm of the renal pelvis of the allograft and multiple lymph nodes with peritoneal metastasis. A diagnosis of a non-muscle-invasive bladder tumor with peritoneal dissemination and jejunal metastasis of urothelial carcinoma was made. After five cycles of gemcitabine and carboplatin, the tumor progressed and pembrolizumab was administered. One week after the first dose, the allograft was rejected, necessitating arterial embolization. After the second cycle, the patient developed Stevens-Johnson syndrome. After discontinuing pembrolizumab, positron emission tomography revealed no increased tumor activity. A complete response was achieved for 21 months without additional treatment. Conclusion: Pembrolizumab was effective in treating urothelial carcinoma of the renal allograft; however, allograft rejection and loss should be considered.
  • Shinsuke Kurokawa, Jun Kamei, Koichi Sakata, Toru Sugihara, Akira Fujisaki, Satoshi Ando, Tatsuya Takayama, Tetsuya Fujimura
    Lower urinary tract symptoms 2022年02月 
    OBJECTIVES: We investigated the efficacy of dutasteride add-on therapy to α-1 adrenoceptor antagonists in patients with benign prostate hyperplasia (BPH) in relation to the transitional zone index (TZI) and evaluated the cutoff value of TZI that predicted improvements of subjective symptoms at 6 months. METHODS: Male BPH patients with prostate volume (PV) ≥ 30 mL receiving dutasteride 0.5 mg/d for 6 months as add-on therapy along with α-1 adrenoceptor antagonists were enrolled. PV, transitional zone volume (TZV), TZI, International Prostate Symptom Score (IPSS), and uroflowmetry parameters before and at 6 months with dutasteride add-on treatment were evaluated. RESULTS: Eighty-three patients were included. The changes of total IPSS, IPSS voiding subscore, IPSS quality of life score, and voided volume were significantly correlated with TZI. Among baseline parameters, TZV and TZI were significantly associated with the changes of total IPSS in univariate analysis, and only TZI remained as an independent predictive factor for improving total IPSS in multivariate analysis (odds ratio -8.3, P = .048). The cutoff point of TZI for predicting an improvement of the total IPSS by 6 points or more was 0.67 (area under the curve 0.71, sensitivity 0.62, specificity 0.79). CONCLUSIONS: A higher TZI was significantly associated with improvement of subjective symptoms but not uroflowmetric findings for BPH patients with 6 months of dutasteride add-on therapy along with α-1 adrenoceptor antagonists, and the predictive value of TZI for effective dutasteride add-on therapy was higher than 0.67. BPH patients using α-1 adrenoceptor antagonists with a TZI higher than 0.67 can be good candidates for add-on dutasteride therapy.
  • Taketo Kawai, Satoru Taguchi, Tohru Nakagawa, Jun Kamei, Yu Nakamura, Daisuke Obinata, Kenya Yamaguchi, Tomoyuki Kaneko, Shigenori Kakutani, Mayuko Tokunaga, Yukari Uemura, Yusuke Sato, Yutaka Enomoto, Hiroaki Nishimatsu, Tetsuya Fujimura, Hiroshi Fukuhara, Satoru Takahashi, Haruki Kume
    Journal for immunotherapy of cancer 10 2 2022年02月 
    BACKGROUND: Several studies have reported the incidence of immune-related adverse events (irAEs) as a predictor of the efficacy of anti-programmed cell death protein 1 antibodies in patients with cancer. However, immortal time bias has not always been fully addressed in these studies. In this retrospective multicenter study, we assessed the association between the incidence of irAEs and the efficacy of pembrolizumab in urothelial carcinoma (UC) using time-dependent analysis, an established statistical method to minimize immortal time bias. METHODS: The study included 176 patients with advanced UC who underwent pembrolizumab treatment at seven affiliated institutions between January 2018 and July 2020. Patients with irAEs were compared with those without irAEs in terms of overall survival (OS) and cancer-specific survival (CSS). Immortal time bias was eliminated by using time-dependent analysis. RESULTS: Of the 176 patients, irAEs occurred in 77 patients (43.8%), with a median of 60 days. The irAEs (+) cohort showed significantly favorable OS and CSS compared with the irAEs (-) cohort (p=0.018 and p=0.005, respectively), especially in the cohort with grade 1-2 irAEs (OS and CSS; p=0.003 and p=0.002, respectively). Multivariate analyses identified any irAEs and grade 1-2 irAEs as independent favorable prognostic factors for OS and CSS. CONCLUSION: Even after minimizing immortal time bias by time-dependent analysis, the incidence of irAEs, especially grade 1-2 irAEs, could be a significant predictor of favorable prognoses in patients with UC who have undergone pembrolizumab treatment.
  • Akiko Matsunaga, Mikako Yoshida, Yusuke Shinoda, Yusuke Sato, Jun Kamei, Aya Niimi, Tetsuya Fujimura, Haruki Kume, Yasuhiko Igawa
    Drug discoveries & therapeutics 16 1 37 - 42 2022年 
    Persistence of urinary incontinence (UI) after robot-assisted radical prostatectomy (RARP) is a bothersome problem because of its negative effect on the patient's quality of life (QOL). This study aimed to evaluate the effect of transperineal ultrasound (TPUS)-guided pelvic floor muscle training (PFMT) on prolonged UI after RARP. Thirty men with stress UI persisting for > 1 year after RARP underwent biofeedback PFMT using TPUS once every 2-3 weeks for 3 months. The frequency and duration of sustaining pelvic floor muscle (PFM) contractions were assessed using ultrasound imaging. The severity of UI and UI-related QOL were evaluated using a 24-hour pad test and the incontinence quality of life (I-QOL) questionnaire. Twenty-four men (mean age, 72.2 years) completed the TPUS-guided PFMT. The mean duration from RARP to PFMT was 1,228.9 days. The mean cumulative session and the total duration of TPUS-guided PFMT were 4.6 times and 73.3 days, respectively. Compared with the data before TPUS-guided PFMT, the frequency of PFM contractions and duration of sustaining contraction significantly improved after TPUS-guided PFMT (p < 0.05). Additionally, the total amount of urinary leakage after TPUS-guided PFMT was reduced significantly (248.6 ± 280.6 g vs. 397.0 ± 427.0 g, p = 0.024). The I-QOL score was significantly increased after TPUS-guided PFMT (72.1 ± 16.8 vs. 61.0 ± 19.0, p < 0.001). TPUS-guided PFMT may be effective in improving prolonged UI occurring > 1 year after RARP.
  • ロボット支援前立腺全摘除術後の尿禁制回復に関与する手術手技 ビデオデータベースの検討
    安東 聡, 横山 博崇, 茗荷 宏昭, 山崎 正博, 亀田 智弘, 小松原 麻衣子, 亀井 潤, 杉原 亨, 藤崎 明, 黒川 真輔, 高山 達也, 藤村 哲也
    日本泌尿器科学会総会 109回 VP05 - 04 (一社)日本泌尿器科学会総会事務局 2021年12月
  • Satoshi Takahashi, Soichi Arakawa, Kiyohito Ishikawa, Jun Kamei, Kanao Kobayashi, Katsumi Shigemura, Satoru Takahashi, Yoshiki Hiyama, Ryoichi Hamasuna, Hiroshi Hayami, Satoshi Yazawa, Mitsuru Yasuda, Yoshikazu Togo, Shingo Yamamoto, Koichiro Wada, Toyohiko Watanabe
    International journal of urology : official journal of the Japanese Urological Association 28 12 1198 - 1211 2021年12月 
    The Committee for the Development of Guidelines for Infection Control in the Urological Field, including Urinary Tract Management of the Japanese Urological Association, together with its systematic review team and external reviewers, have prepared a set of practice guidelines, an abridged version of which is published herein. These guidelines cover the following topics: (i) foundations of infection control, standard precautions, route-specific precautions, and occupational infection control (including vaccines); (ii) the relationship between urologists and infection control; (iii) infection control in urological wards and outpatient clinics; (iv) response to hepatitis B virus reactivation; (v) infection control in urological procedures and examinations; (vi) prevention of infections occurring in conjunction with medical procedures and examinations; (vii) responses to urinary tract tuberculosis and bacillus Calmette-Guérin; (viii) aseptic handling, cleaning, disinfection, and sterilization of urinary tract endoscopes (principles of endoscope manipulation, endoscope lumen cleaning, and disinfection); (ix) infection control in the operating room (principles of hand washing, preoperative rubbing methods, etc.); (x) prevention of needlestick and blood/bodily fluid exposure and response to accidental exposure; (xi) urinary catheter-associated urinary tract infection and purple urinary bag syndrome; and (xii) urinary catheter-associated urinary tract infections in conjunction with home care. In addressing these topics, the relevant medical literature was searched to the extent possible, and content was prepared for the purpose of providing useful information for clinical practice.
  • Jun Kamei, Akira Fujisaki, Kimitoshi Saito, Toru Sugihara, Satoshi Ando, Tomoaki Miyagawa, Tatsuya Takayama, Tetsuya Fujimura
    Asian journal of endoscopic surgery 2021年10月 
    INTRODUCTION: To clarify the safety and efficacy of en bloc simultaneous robot-assisted radical cystectomy (RARC) and laparoscopic nephroureterectomy (LNU) for synchronous muscle-invasive bladder carcinoma and upper tract urothelial carcinoma (UTUC) or UTUC of a solitary kidney, we evaluated the perioperative and short-term outcomes of this surgical procedure compared with those of simultaneous open radical cystectomy and nephroureterectomy. METHODS: We prospectively enrolled consecutive patients receiving en bloc simultaneous RARC and LNU between December 2018 and March 2020 at two institutes. Patients' characteristics, surgical, perioperative, and pathological outcomes and recurrence rate within 6 months were compared with a historical control receiving simultaneous open radical cystectomy and nephroureterectomy. RESULTS: Ten patients receiving simultaneous RARC and LNU and 17 receiving simultaneous open radical cystectomy and nephroureterectomy were included in the study. Simultaneous RARC and LNU significantly reduced bleeding volume and blood transfusion (P < .0001, P < .0001, respectively) and significantly prolonged operating time (P = .035). RARC and LNU significantly shortened hospitalization after operation (P = .003) and showed reduced tendency of postoperative complications within 30 days but not significantly (P = .25). Pathological characteristics and recurrence within 6 months were not significantly different between the two groups. CONCLUSION: Our results suggested that en bloc simultaneous RARC and LNU were safer surgical procedures with equivalent short-term oncological outcomes compared to conventional open procedures. It can be a standard minimally invasive surgical method in countries where robot-assisted radical nephroureterectomy is inaccessible.
  • 前立腺肥大症患者のTransitional zone indexはデュタステリド内服6ヵ月後の自覚所見改善の予測因子になる
    亀井 潤, 黒川 真輔, 杉原 亨, 藤崎 明, 安東 聡, 高山 達也, 藤村 哲也
    日本排尿機能学会誌 32 1 184 - 184 (一社)日本排尿機能学会 2021年09月
  • Tatsuya Takayama, Akifumi Fujita, Toru Sugihara, Akira Fujisaki, Masahiro Yamazaki, Tomohiro Kameda, Jun Kamei, Satoshi Ando, Shinsuke Kurokawa, Tetsuya Fujimura
    Translational andrology and urology 10 9 3555 - 3565 2021年09月 
    Background: We assessed the natural history of renal artery pseudoaneurysm (RAP) after robot-assisted partial nephrectomy (RAPN). Methods: From May 2016 to September 2020, 106 patients underwent RAPN for renal tumors at our institution. Among 100 patients, excluding 6 who were ineligible for contrast-enhanced computed tomography (CE-CT), 4 underwent renal artery selective embolization (RAE), of which 2 cases were emergency RAE within 7 days after RAPN and the other 2 were prophylactic RAE 8 or more days after RAPN. In 98 patients examined for the clinical course of asymptomatic RAP managed by surveillance, excluding the 2 who underwent emergency RAE, routine CE-CT was performed at 7 days, 1 month and 3 months after RAPN. Factors influencing the occurrence of RAP among these 98 patients, including the 2 who underwent emergency RAE and excluding the 2 who underwent prophylactic RAE, were analyzed by logistic regression analysis. Results: Median [interquartile range (IOR), range] observation period, age, radiographic tumor size, and maximum diameter of RAP were 20.8 (23.9, 3.0-57.6) months, 63 (18, 22-84) years, 23 (11, 9-48) mm, and 6.6 (5.2, 3.0-16.0) mm, respectively. CE-CT detected 28 RAPs in 23 (23.0%) of 100 patients by 7 days after RAPN and routine CE-CT detected 25 RAPs in 21 (21.4%) of 98 patients excluding 2 who underwent emergency RAE at 7 days after RAPN. RAP was diagnosed by routine CE-CT in 21 (21.4%), 1 (1.0%), and 0 (0%) patients at 7 days, 1 month, and 3 months after RAPN, respectively. In univariate analysis, age [odds ratio (OR) 0.144: 69-84 vs. 22-56 years old, P=0.0179], R.E.N.A.L [radius (tumor size as maximal diameter), exophytic/endophytic properties of tumor, nearness of tumor deepest portion to collecting system or sinus, anterior/posterior descriptor and location relative to polar line] nephrometry score (OR 1.374, P=0.0382), warm ischemic time (OR 1.085, P=0.0393), and renorrhaphy time (OR 1.055, P=0.0408) were significantly associated with the occurrence of RAP. In multivariate analysis, only age (OR 0.124, P=0.0148) was a significant factor. Conclusions: Asymptomatic RAP up to 15 mm in diameter resolved spontaneously 3 months after RAPN. Young age (under 56 years) may be a factor in the development of RAP.
  • Akira Fujisaki, Tatsuya Takayama, Takumi Teratani, Taro Kubo, Jun Kamei, Toru Sugihara, Satoshi Ando, Tatsuo Morita, Tetsuya Fujimura
    International Journal of Urology 28 12 1274 - 1280 2021年08月 
    OBJECTIVES: To evaluate thermal denaturation depth using soft coagulation in kidneys in vivo. METHODS: In experiment 1, nine kidneys from five pigs were cauterized using five soft-coagulation settings at 80 W with effect 7 by VIO300D and one monopolar-coagulation setting. The surface of the kidney was cauterized over a period of 2, 5 and 10 s. The temperature change was measured at depths of 5 and 10 mm. In experiment 2, three kidneys from two pigs were excised in a semicircular shape with a diameter of 5, 10 and 20 mm without clamping the renal artery. Cauterization was carried out until hemostasis was confirmed by soft coagulation at 80 W with effect 7. After completion of the experiments, pathology examinations of the kidneys were carried out. RESULTS: Experiment 1 showed that with proper saline dripping, denaturation spread with increased cauterization time, reaching a depth of 4 mm at 10 s with or without clamps. The depth remained at 2-3 mm at 10 s in the absence or excess of saline. The temperature increased by 15.6°C at a depth of 5 mm and 8.8°C at 10 mm. In experiment 2, the depth was 4.6 mm from the incision surface regardless of the cauterization time or excision size. CONCLUSIONS: These findings suggest that soft coagulation can be useful for preserving renal function and reducing complications in partial nephrectomy.
  • Satoru Taguchi, Taketo Kawai, Tohru Nakagawa, Yu Nakamura, Jun Kamei, Daisuke Obinata, Kenya Yamaguchi, Tomoyuki Kaneko, Shigenori Kakutani, Mayuko Tokunaga, Yukari Uemura, Yusuke Sato, Tetsuya Fujimura, Hiroshi Fukuhara, Yutaka Enomoto, Hiroaki Nishimatsu, Satoru Takahashi, Haruki Kume
    Scientific reports 11 1 15623 - 15623 2021年08月 
    Although the albumin-to-globulin ratio (AGR) is a promising biomarker, no study has investigated its prognostic significance for advanced urothelial carcinoma (UC). This study conformed to the REporting recommendations for tumor MARKer prognostic studies (REMARK) criteria. We retrospectively reviewed 176 patients with advanced UC treated with pembrolizumab between 2018 and 2020. We evaluated the associations between pretreatment clinicopathological variables, including the AGR and performance status (PS), with progression-free survival, cancer-specific survival, and overall survival. The Cox proportional hazards model was used for univariate and multivariable analyses. The AGR was dichotomized as < 0.95 and ≥ 0.95 based on receiver operating characteristic curve analysis. After excluding 26 cases with missing data from the total of 176 cases, 109 (73%) patients experienced disease progression, 75 (50%) died from UC, and 6 (4%) died of other causes (median survival = 12 months). Multivariate analyses identified PS ≥ 2 and pretreatment AGR < 0.95 as independent poor prognostic factors for all endpoints. Furthermore, a prognostic risk model incorporating these two variables achieved a relatively high concordance index for all endpoints. This is the first report to evaluate the significance of AGR in advanced UC. Pretreatment AGR < 0.95 may serve as a prognostic marker for advanced UC treated with pembrolizumab.
  • Jun Kamei, Shingo Yamamoto
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 27 8 1131 - 1136 2021年08月 
    Patients with diabetes mellitus (DM) sometimes exhibited impaired immune function and aggravated infectious diseases. Urinary tract infection (UTI) is one of the major complications of DM. A systematic literature search was performed in PubMed and Cochrane Library using the following keywords: diabetes mellitus, urinary tract infection, asymptomatic bacteriuria, emphysematous pyelonephritis, emphysematous cystitis, renal papillary necrosis, and sodium-glucose co-transporter 2 (SGLT2) inhibitors. The treatment of UTI in DM patients is not different from that in non-DM patients, and asymptomatic bacteriuria should not be screened or treated. Emphysematous pyelonephritis is a life-threatening renal infection with gas in the renal parenchyma or perirenal space, and 95% of affected patients had DM. Abdominal computed tomography is useful for diagnosis and determining treatment strategies. Medical management and percutaneous drainage are standard initial treatment, and subsequent nephrectomy for non-responders is considered. Nephrectomy, as an initial treatment, should be limited to a selected group of patients with severe conditions. In contrast, antibiotics, glycemic control, and bladder drainage are adequate treatment for most cases of emphysematous cystitis. SGLT2 inhibitors significantly increased the incidence of genital tract infection, but not that of UTI, pyelonephritis, or urosepsis. Here, we present cumulative evidence about etiology and management for complicated UTI with DM, but there was little information about racial differences and further evidence focusing on Asian population will be needed.
  • Toshihiro Shimizu, Toru Sugihara, Jun Kamei, Saki Takeshima, Yoshitaka Kinoshita, Taro Kubo, Takahiro Shinzato, Tetsuya Fujimura, Takashi Yagisawa
    Clinical and experimental nephrology 25 2 200 - 206 2021年02月 
    BACKGROUND: Urinary tract infection (UTI) is one of the most common infectious complications in kidney transplant recipients. The aims of our study were to identify possible predictive factors for UTI and advocate for the management of UTI after kidney transplantation (KT). METHODS: Between January 2013 and December 2018, 182 adult patients with end-stage kidney disease who underwent KT were retrospectively analyzed. Patients who had urinary symptoms and positive urine culture were diagnosed with UTI. The types of urinary bacteria causing UTIs were also examined. RESULTS: UTIs occurred in forty-one patients (25.1%), and the median time to UTI onset (UTI-free survival) after KT was 189 days. The Cox hazard regression analysis showed that the predictive factors for UTI onset were as follows: posttransplant urinary catheterization, including indwelling urinary catheterization and clean intermittent catheterization; a maximum bladder capacity before KT of less than 150 ml; and a low serum albumin level at 1 month after KT. The most common causative agent was Escherichia coli (56.6%), followed by Enterococcus spp. (15.6%) and Klebsiella spp. CONCLUSIONS: Kidney transplant recipients with prolonged postoperative malnutrition, posttransplant voiding dysfunction and/or urinary storage disorder had an increased risk of UTI. Bladder function tests, such as uroflowmetry, postvoid residual urine tests, and urodynamic tests, were needed to predict UTI. For patients with malnutrition, care should be taken to ensure sufficient calorie intake. Kidney transplant recipients who develop UTI should be treated as complicated UTI patients.
  • Akira Fujisaki, Tatsuya Takayama, Masahiro Yamazaki, Tomoki Kamimura, Saki Katano, Maiko Komatsubara, Jun Kamei, Toru Sugihara, Satoshi Ando, Tetsuya Fujimura
    Translational andrology and urology 9 6 2697 - 2704 2020年12月 
    Background: This retrospective study aimed to investigate whether a three-dimensional (3D) model would improve the achievement of TRIFECTA, which was defined as the absence of perioperative complications and positive surgical margins and a warm ischemia time of <25 minutes, during robot-assisted partial nephrectomy (RAPN). Methods: Prior to RAPN, a 3D-square type kidney model was prepared and used for all RAPN procedures in patients with T1a renal cell carcinoma (RCC) treated at a single center between March 2016 and April 2019. All RAPN procedures were performed by a single surgeon. Results: The study included 50 patients, of whom 22, 24, and 4 had low-, intermediate-, and high-risk R.E.N.A.L Nephrometry scores, respectively. The TRIFECTA achievement rate was 86.0%, and transfusion or conversion to radical nephrectomy was not required in any of the patients. Only one Clavien-Dindo grade 3 complication was reported-a pseudoaneurysm that required embolism. The TRIFECTA achievement rate was independent of the R.E.N.A.L Nephrometry scores and the surgeon's experience level (25 cases each of early and advanced experience). Conclusions: The 3D model contributed to the achievement of TRIFECTA during RAPN performed by a less-experienced surgeon. These findings should be further evaluated in studies involving a larger number of cases and surgeons.
  • 陰茎折症9例の臨床的特徴
    亀田 智弘, 高山 達也, 山崎 正博, 小松原 麻衣子, 亀井 潤, 杉原 亨, 藤崎 明, 安東 聡, 藤村 哲也, 坂田 浩一
    日本性機能学会雑誌 35 3 117 - 121 (一社)日本性機能学会 2020年12月 
    【目的】当院で経験した陰茎折症9例の臨床的特徴を報告する。【対象と方法】1999年5月から2015年6月まで陰茎折症と診断された9例を対象とした。診療録から患者背景、受傷機転、身体所見、画像検査結果、手術所見、術後合併症を調査した。【結果】年齢の中央値は45歳(28-66)だった。受傷機転は性交中の受傷が5例(55.6%)と最も多かった。身体所見としては陰茎の屈曲、腫脹は全例に認め、陰茎の断裂音は5例(55.6%)に認めた。全例で緊急手術を行い、白膜断裂部位の修復を行った。受傷から手術までの時間の中央値は6時間(3-24)であった。陰茎近位での損傷が4例(44.4%)と最も多く、陰茎海綿体の損傷は右側が7例(77.8%)と最も多かった。術後経過観察期間の中央値は26日間(1-286)で、重篤な術後合併症は認めず、観察期間の範囲では勃起不全を合併した症例も認めなかった。【結語】陰茎折症の9例の臨床的特徴を報告した。(著者抄録)
  • Yoshitaka Kinoshita, Takashi Yagisawa, Toru Sugihara, Konan Hara, Saki Takeshima, Taro Kubo, Takahiro Shinzato, Toshihiro Shimizu, Michiko Suzuki, Akito Maeshima, Jun Kamei, Akira Fujisaki, Satoshi Ando, Motofumi Suzuki, Haruki Kume, Tetsuya Fujimura
    Transplant international : official journal of the European Society for Organ Transplantation 33 11 1417 - 1423 2020年11月 
    We retrospectively compared the post-transplantation graft survival and the donor's estimated glomerular filtration rates (eGFRs) following living donor kidney transplantations (LDKTs) involving medically complex living donors (MCLDs) (the elderly and patients with obesity, hypertension, diabetes mellitus, or reduced renal function) and standard living donors (SLDs). The clinical data on patients who underwent LDKTs at our institution from 2006-2019, including 192 SLDs and 99 MCLDs, were evaluated. Regarding recipients, the log-rank test and multivariable Cox proportional hazards analyses showed a higher incidence of overall and death-censored graft loss in the recipients who received kidneys from MCLDs (Hazard ratio = 2.16 and 3.25, P = 0.015 and 0.004, respectively), after adjusting for recipient-related variables including age, sex, duration of dialysis, ABO compatibility, and donor-specific antibody positivity. Regarding donors, a linear mixed model showed significantly lower postdonation eGFRs (-2.25 ml/min/1.73 m2 , P = 0.048) at baseline in MCLDs than SLDs, but comparable change (difference = 0.01 ml/min/1.73 m2 /year, P = 0.97). In conclusion, although kidneys from MCLDs are associated with impaired graft survival, the donation did not adversely affect the MCLDs' renal health in at least the short-term. LDKTs involving carefully selected MCLDs would be an acceptable alternative for recipients with no SLDs.
  • Shinsuke Kurokawa, Jun Kamei, Koichi Sakata, Toru Sugihara, Akira Fujisaki, Satoshi Ando, Tatsuya Takayama, Tatsuo Morita, Tetsuya Fujimura
    Turkish journal of urology 46 6 468 - 473 2020年11月 
    OBJECTIVE: A prospective questionnaire survey was conducted for patients with benign prostatic hyperplasia (BPH) to clarify seasonal changes in the lower urinary tract symptoms (LUTS). MATERIAL AND METHODS: Male patients receiving α1-adrenoreceptor antagonists for BPH were enrolled. They answered the International Prostate Symptom Score (IPSS) questionnaire, and an unvalidated questionnaire that consisted of 10 questions assessing variations in the urinary stream (voiding symptoms) and urinary frequency (storage symptoms), depending upon the seasons or the patients' subjective sensations of warm and cold in last one year. RESULTS: A total of 412 participants answered IPSS and our unvalidated questionnaire. Of the 412 participants, 36.7% and 59.0% realized seasonal variations in urinary stream and frequency, respectively. Among patients perceiving seasonal urinary stream and urinary frequency changes (n=151 and n=243, respectively), significantly more patients realized weaker urinary stream, 59.8% (107/179) in winter compared with 26.2% (47/179) in summer, and increased urinary frequency, 69.8% (199/285) in winter compared with 20.7% (59/285) in summer (p<0.0001 and p<0.0001, respectively). Even in summer, when feeling cold, 34.7% and 56.3% realized a weaker urinary stream and an increased urinary frequency, and even in winter, when feeling warm, 53.4% and 69.4% realized a stronger urinary stream and a decreased urinary frequency. Those with seasonal stream changes showed a significantly higher IPSS total, voiding and post-voiding scores than those without, and those with seasonal frequency changes showed significantly higher IPSS total, storage, voiding, and post-voiding scores. CONCLUSION: Our results revealed seasonal changes and feeling of hot and cold were associated with subjective changes of LUTS in BPH patients.
  • Jun Kamei, Naoki Aizawa, Takayuki Nakagawa, Shuji Kaneko, Tetsuya Fujimura, Yukio Homma, Haruki Kume, Yasuhiko Igawa
    International journal of urology : official journal of the Japanese Urological Association 28 1 107 - 114 2020年10月 
    OBJECTIVE: To study the role of transient receptor potential melastatin 2 in bladder function and inflammation-associated hypersensitivity. METHODS: We evaluated physiological function of the bladder and intravesical lipopolysaccharide-induced inflammatory nociceptive responses in female wild-type and transient receptor potential melastatin 2-knockout mice. In vivo frequency/volume and decerebrated unanesthetized cystometry measurements, as well as in vitro detrusor strip functional studies, were carried out to evaluate bladder function. Mice received intravesical lipopolysaccharide (2.0 mg/mL) or saline instillation to evaluate responses to bladder inflammation. Voiding and bladder pain-like behaviors, cystometry measurements and histological evaluation were carried out before and after intravesical lipopolysaccharide instillation. RESULTS: Few phenotypic differences in in vivo and in vitro physiological function were found between the two genotypes. Comparison of measurements taken before and 24-48 h after intravesical lipopolysaccharide instillation showed that voiding parameters did not change in transient receptor potential melastatin 2-knockout mice, whereas an increased voiding frequency was observed in wild-type mice. At 24 h after intravesical lipopolysaccharide instillation, the numbers of bladder pain-like behaviors and of infiltrated inflammatory cells in the bladder submucosal layer were significantly increased, and the voided volume and the intercontraction interval were significantly decreased on cystometry measurements in wild-type mice compared with those in both transient receptor potential melastatin 2-knockout mice and in wild-type mice treated with saline instillation. CONCLUSIONS: Although the physiological roles of transient receptor potential melastatin 2 channels in the bladder might be limited, inflammation and associated hypersensitivity of the bladder caused by intravesical lipopolysaccharide instillation are attenuated in transient receptor potential melastatin 2-knockout mice, suggesting pathophysiological roles of transient receptor potential melastatin 2 channels in these processes.
  • 転移性ホルモン感受性前立腺癌に対するupfrontドセタキセル化学療法の治療成績
    杉原 亨, 永野 牧郎, 早瀬 貴徳, 横山 博崇, 茗荷 宏昭, 山崎 正博, 亀田 智弘, 小松原 麻衣子, 亀井 潤, 藤崎 明, 安東 聡, 高山 達也, 藤村 哲也
    日本癌治療学会学術集会抄録集 58回 P - 379 (一社)日本癌治療学会 2020年10月
  • 山崎 正博, 茗荷 宏昭, 眞弓 翔三朗, 竹嶋 咲, 小松原 麻衣子, 亀田 智弘, 亀井 潤, 杉原 亨, 藤崎 明, 安東 聡, 黒川 真輔, 高山 達也, 藤村 哲也
    泌尿器外科 33 9 1249 - 1249 医学図書出版(株) 2020年09月
  • 亀井 潤, 茗荷 宏昭, 眞弓 翔三朗, 竹嶋 咲, 山崎 正博, 小松原 麻衣子, 亀田 智弘, 杉原 亨, 黒川 真輔, 藤崎 明, 安東 聡, 高山 達也, 藤村 哲也
    泌尿器外科 33 9 1250 - 1250 医学図書出版(株) 2020年09月
  • Kanao Kobayashi, Shingo Yamamoto, Satoshi Takahashi, Kiyohito Ishikawa, Mitsuru Yasuda, Koichiro Wada, Ryoichi Hamasuna, Hiroshi Hayami, Shinichi Minamitani, Tetsuya Matsumoto, Hiroshi Kiyota, Kazuhiro Tateda, Junko Sato, Hideaki Hanaki, Naoya Masumori, Yoshiki Hiyama, Hiroki Yamada, Shin Egawa, Takahiro Kimura, Hiroyuki Nishiyama, Jun Miyazaki, Kazumasa Matsumoto, Yukio Homma, Jun Kamei, Kiyohide Fujimoto, Kazumasa Torimoto, Kazushi Tanaka, Yoshikazu Togo, Shinya Uehara, Akio Matsubara, Koichi Shoji, Hirokazu Goto, Hisao Komeda, Toru Ito, Katsuhisa Mori, Koji Mita, Masao Kato, Yoshinori Fujimoto, Takako Masue, Hisato Inatomi, Yoshito Takahashi, Satoshi Ishihara, Kazuo Nishimura, Kenji Mitsumori, Noriyuki Ito, Sojun Kanamaru, Daisuke Yamada, Maeda Hiroshi, Masuo Yamashita, Masaya Tsugawa, Tadasu Takenaka, Koichi Takahashi, Yasuhiko Oka, Tomihiko Yasufuku, Shuji Watanabe, Yoshitomo Chihara, Kazuhiro Okumura, Hiroaki Kawanishi, Masanori Matsukawa, Masanobu Shigeta, Shuntaro Koda
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 26 5 418 - 428 2020年05月 
    The antimicrobial susceptibility patterns of bacterial pathogens isolated from patients with complicated urinary tract infections were analyzed using national surveillance data. The data consisted of 881 bacterial strains from eight clinically relevant species. The data were collected for the third national surveillance project from January 2015 to March 2016 by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Disease, and the Japanese Society of Clinical Microbiology. Surveillance was undertaken with the cooperation of 41 medical institutions throughout Japan. Fluoroquinolone required a MIC90 of 2-64 mg/L to inhibit the 325 Escherichia coli strains tested and the proportion of levofloxacin resistant E. coli strains increased to 38.5% from 29.6% in 2011 and 28.6% in 2008. The proportion of levofloxacin resistant strains of Pseudomonas aeruginosa and Enterococcus faecalis decreased from previous reports and the proportion of multidrug-resistant P. aeruginosa and carbapenem-resistant Enterobacteriaceae remained low. Among methicillin-resistant Staphylococcus aureus (MRSA) strains, strains with reduced susceptibility to vancomycin (minimum inhibitory concentration, 2 μg/mL) increased to 14.7% from 5.5%. Bacterial strains that produced extended-spectrum β-lactamase included E. coli (79 of 325 strains, 24.3%), Klebsiella pneumoniae (9 of 177 strains, 7.7%), and Proteus mirabilis (6 of 55 strains, 10.9%). The proportion of extended-spectrum β-lactamase producing E. coli and K. pneumoniae strains increased from previous surveillance reports.
  • 竹嶋 咲, 杉原 亨, 山崎 正博, 小松原 麻衣子, 亀田 智弘, 亀井 潤, 藤崎 明, 安東 聡, 高山 達也, 藤村 哲也
    泌尿器外科 33 5 544 - 544 医学図書出版(株) 2020年05月
  • 亀田 智弘, 藤崎 明, 高山 達也, 竹嶋 咲, 山崎 正博, 小松原 麻衣子, 亀井 潤, 杉原 亨, 安東 聡, 寺内 文人, 黒川 真輔, 中西 公司, 森田 辰男, 藤村 哲也
    泌尿器外科 33 5 544 - 544 医学図書出版(株) 2020年05月
  • Tomohiro Kameda, Tatsuya Takayama, Toru Sugihara, Saki Takeshima, Masahiro Yamazaki, Maiko Komatsubara, Jun Kamei, Akira Fujisaki, Satoshi Ando, Shinsuke Kurokawa, Tetsuya Fujimura
    Asia-Pacific journal of clinical oncology 16 4 241 - 246 2020年03月 [査読有り][通常論文]
     
    AIM: To evaluate predictive factors which associated with oncological outcomes to first-line axitinib for metastatic renal cell carcinoma (mRCC). METHODS: A retrospective chart review was conducted patients who had been treated with axitinib as first-line therapy for the treatment of mRCC from September 2013 to February 2018. Axitinib was given by single daily oral administration at a dose of 10 mg, which was reduced according to adverse events (AEs). We investigated progression-free survival (PFS), overall survival (OS), objective response rate (ORR) and AEs. RESULTS: Thirty-eight mRCC patients were enrolled. The median follow-up duration of axitinib treatment was 11.3 months (range = 1.0-56.9). ORR was 28.9%. Median PFS and OS was 12.8, and 17.9 months, respectively. In univariate analysis, baseline lactate dehydrogenase (LDH), neutrophil, corrected calcium (Ca), platelets (Plt) and time from diagnosis were selected as potential predictive factors. Multivariate Cox's proportional hazards model analysis showed that the number of risk factors were associated with PFS (P = 0.03) and OS (P = 0.02). CONCLUSION: Baseline LDH, neutrophil, Ca, Plt and time from diagnosis are predictive factors for both PFS and OS in first-line treatment with axitinib for metastatic renal cell carcinoma.
  • 岩田 翔平, 松井 甫雄, 木下 義隆, 亀井 潤, 佐藤 悠佑, 川合 剛人, 山田 大介, 松本 明彦, 鈴木 基文, 井川 靖彦, 久米 春喜, 石橋 牧子, 星 和人, 阿部 雅修, 松本 陽子, 曾根 献文, 尾松 淳, 松田 和樹, 三枝 良輔, 山田 大資
    泌尿器外科 33 2 200 - 200 医学図書出版(株) 2020年02月 [査読有り][通常論文]
  • Akira Fujisaki, Tatsuya Takayama, Masahiro Yamazaki, Maiko Komatsubara, Jun Kamei, Toru Sugihara, Satoshi Ando, Tetsuya Fujimura
    Journal of endourology case reports 6 4 448 - 450 2020年 
    Background: Delayed postoperative bleeding after robot-assisted radical prostatectomy (RARP) is a rare life-threatening condition. We present such a case wherein a patient developed hemorrhagic shock from a ruptured pseudoaneurysm arising from the epigastric artery and discuss its management. Case Presentation: A 71-year-old man with prostate cancer underwent RARP. The urethral catheter was removed on postoperative day 7; 80 minutes later, the patient suddenly lost consciousness and went into shock. Enhanced CT revealed intra-abdominal bleeding; however, the cause was unknown. Intraoperatively, bleeding was observed from the anterior abdominal wall, which likely corresponded to the epigastric artery. However, this was controlled with monopolar electrocautery. Because of unstable hemodynamics, hemostasis was immediately performed by laparotomy, and bleeding was noted from the previously coagulated right inferior epigastric artery. Therefore, the cause was considered to be the rupture of a pseudoaneurysm. Conclusion : Our experience suggests that monopolar electrocautery may be inadequate for controlling bleeding that may be encountered during RARP, possibly leading to pseudoaneurysm formation, which may cause a delayed life-threatening hemorrhage. Meticulous and precise hemostasis is key to avoiding this complication.
  • 竹嶋 咲, 杉原 亨, 河田 浩敏, 山崎 正博, 小松原 麻衣子, 亀田 智弘, 亀井 潤, 藤崎 明, 安東 聡, 高山 達也, 藤村 哲也
    泌尿器外科 32 12 1533 - 1536 医学図書出版(株) 2019年12月 
    50歳男性。右腎腫瘍による下大静脈圧迫に伴う血栓形成と肺塞栓症により心肺停止となり当院へ救急搬送された。肺動脈血栓吸引後も、下大静脈の圧排で循環動態が安定せず、右腎摘除術とリンパ節切除術を施行した。病理結果は腎肉腫であった。術後、抜管され会話が可能となり一時は歩行できるまで回復したが術後90日で癌死した。腎原発肉腫は稀な病態であり治療法も確立しておらず、予後も不良である。(著者抄録)
  • 亀田 智弘, 高山 達也, 鈴木 貴大, 竹嶋 咲, 山崎 正博, 小松原 麻衣子, 亀井 潤, 杉原 亨, 藤崎 明, 安東 聡, 藤村 哲也, 中西 公司, 坂田 浩一
    日本性機能学会雑誌 34 3 229 - 232 (一社)日本性機能学会 2019年12月 
    症例は46歳男性。201X年Y月に性風俗店の利用を断ちたいという目的で自己の陰茎切断を試みるも不完全に終わり、近医で白膜縫合を受けた。9ヵ月後に妻から離婚を切り出され、再度自己陰茎切断を行い当院へ救急搬送された。来院時、陰茎は根部から完全に切断されていたが、ほぼ止血が得られており、血圧、心拍数などのバイタルサインも大きな異常はなかった。再度陰茎を自己切断する可能性が高く、断端形成術や再吻合術は適さないと判断し、尿道瘻形成術を施行した。術後に精神科にコンサルトし、精神科的な疾患はなく、性風俗店への依存と判断された。退院後2ヵ月で通院を自己中断した。(著者抄録)
  • 去勢抵抗性前立腺癌に対するRadium-223の治療成績
    高山 達也, 眞弓 翔三朗, 茗荷 宏昭, 竹嶋 咲, 山崎 正博, 小松原 麻衣子, 亀田 智弘, 亀井 潤, 杉原 亨, 藤崎 明, 安東 聡, 藤村 哲也
    日本癌治療学会学術集会抄録集 57回 P108 - 3 2019年10月
  • Takayama T, Kubo T, Yamazaki M, Takeshima S, Komatsubara M, Kameda T, Kamei J, Sugihara T, Fujisaki A, Ando S, Kurokawa S, Fujimura T
    Japanese journal of clinical oncology 49 12 1164 - 1171 2019年10月 [査読有り][通常論文]
     
    OBJECTIVES: The efficacy and safety of sunitinib versus sorafenib in patients with advanced renal cell carcinoma with renal impairment remains poorly documented. PATIENTS AND METHODS: We assessed the efficacy and safety of sunitinib and sorafenib in patients with advanced renal cell carcinoma with an estimated glomerular filtration rate of 15-60 mL/min/1.73 m2 by reviewing the medical records of patients treated at Jichi Medical University Hospital, Japan, between May 2008 and August 2016. RESULTS: Twenty-seven patients were treated with sunitinib and 14 with sorafenib. Median progression-free survival in sunitinib- and sorafenib-treated patients was comparable, at 6.6 vs 5.8 months, respectively (HR, 1.618; 95% CI, 0.689-3.798; P = 0.2691). Median overall survival was also comparable, at 65.9 vs 58.0 months (HR, 0.985; 95% CI, 0.389-2.479; P = 0.9748). Grade 3 or higher adverse events were significantly more frequent in the sunitinib-treated than sorafenib-treated patients (P = 0.0357). Compared to pre-treatment values, estimated glomerular filtration rate at the discontinuation of treatment was not decreased in either group. In contrast, estimated glomerular filtration rate was decreased on long-term treatment, particularly in previously nephrectomized patients. CONCLUSIONS: Sunitinib and sorafenib had similar efficacy in patients with advanced renal cell carcinoma and severe renal impairment. Although renal function was not markedly impaired in either group, close attention to decreased renal function may be necessary in previously nephrectomized patients on long-term treatment.
  • アンケート調査による前立腺肥大症患者に伴う下部尿路症状と季節との関係
    黒川 真輔, 亀井 潤, 茗荷 宏昭, 眞弓 翔三朗, 竹嶋 咲, 山崎 正博, 小松原 麻衣子, 亀田 智弘, 杉原 亨, 藤崎 明, 安東 聡, 高山 達也, 藤村 哲也
    日本排尿機能学会誌 30 1 315 - 315 (一社)日本排尿機能学会 2019年09月
  • Jun Kamei, Satoshi Yazawa, Shingo Yamamoto, Naoto Kaburaki, Satoru Takahashi, Masami Takeyama, Masayasu Koyama, Soichi Arakawa, Hiroshi Kiyota
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 25 7 567 - 570 2019年07月 
    We performed a questionnaire-based, retrospective, nationwide survey on perioperative management and antimicrobial prophylaxis for mid-urethral sling surgery for stress urinary incontinence in Japan to realize the clinical practice and risk factors for SSI. Records of women receiving transobturator tape (TOT) and tension-free vaginal tape (TVT) surgeries from 2010 to 2012 were obtained from hospitals belonging to the Japanese Society of Pelvic Organ Prolapse Surgery. The questionnaire addressed hospital volume, perioperative management, and SSI. Risk factors for SSI were investigated by comparing cases with and without SSI. The data from 97 hospitals and a total 1627 TOT and 1045 TVT surgeries were analyzed. Mean case volumes of TOT and TVT surgeries were 7.3 ± 14.9 and 7.1 ± 17.8 cases per year, respectively. Preoperative hair removal, bowel preparation, and urine culture were routinely performed at 44 (45.3%), 31 (32.0%), and 22 (22.7%) hospitals, respectively. First-generation (51.5%) or second-generation (34.0%) cephalosporin was mostly used for antimicrobial prophylaxis. SSI was reported only in 6 patients (0.22%) and none of them developed abscesses. None of the factors we could evaluate from the questionnaire were found to be significantly associated with SSI. SSI after mid-urethral slings rarely occurred in Japan (0.22%) and no parameters about perioperative managements significantly increased SSI. However, further studies with more detail information of each patient and operation are required to confirm their appropriate perioperative managements for mid-urethral slings.
  • 山田 大介, 川合 剛人, 佐藤 悠佑, 松本 明彦, 井川 靖彦, 中村 真樹, 野宮 明, 前川 滋克, 秋山 佳之, 亀井 潤, 手島 太郎, 松井 甫雄, 久米 春喜
    泌尿器外科 32 臨増 745 - 745 医学図書出版(株) 2019年06月 [査読有り][通常論文]
  • Jun Kamei, Daiji Watanabe, Yukio Homma, Haruki Kume, Yasuhiko Igawa
    Lower urinary tract symptoms 11 3 169 - 173 2019年05月 
    OBJECTIVE: This study examined the accuracy of a new portable ultrasound bladder scanner, the Lilium α-200 (Lilium Otsuka, Kanagawa, Japan), by evaluating the correlation between bladder volumes periodically measured by the Lilium α-200 and instilled volume during video-urodynamic studies (V-UDS). METHODS: Using the Lilium α-200, fluid volume was measured prospectively in the bladders of patients with lower urinary tract dysfunction during V-UDS. This was done both immediately after micturition (for assessment of post-void residual [PVR] volume) and at 1-minute intervals during filling cystometry with patients in the supine position. These measurements were then compared with the PVR volume obtained directly by catheter drainage and instilled volume during cystometry using paired t tests and Spearman's rank correlation. RESULTS: Fifteen male patients (median age 70.5 years; range 18-84 years) were included in the study. The PVR volume measured by the Lilium α-200 was strongly correlated with that obtained by catheter drainage (r = 0.94; P < 0.0001). There was a strong correlation between instilled and bladder volumes measured by the Lilium α-200 at every minute during and at the end of instillation (281 measurements in 15 patients; r = 0.86; P < 0.0001). However, the relative error of bladder volumes measured by the Lilium α-200 during cystometry showed considerable variation (mean [± SD] 5.6 ± 62.9%). CONCLUSIONS: Bladder volumes measured periodically by the Lilium α-200 during cystometry were strongly correlated with actual PVR or instilled volumes. However, they showed considerable variation and may not predict actual volume accurately. The Lilium α-200 is feasible for obtaining an approximate measure of bladder volume.
  • Energy deviceによる副腎の電気凝固で発生する高血圧メカニズムの解明
    高山 達也, 鈴木 基文, 藤崎 明, 寺谷 工, 黒川 真輔, 山崎 正博, 亀田 智弘, 竹嶋 咲, 亀井 潤, 杉原 亨, 安東 聡, 藤村 哲也
    日本泌尿器科学会総会 107回 PP1 - 114 (一社)日本泌尿器科学会総会事務局 2019年04月
  • Fujimura Tetsuya, Igawa Yasuhiko, Aizawa Naoki, Niimi Aya, Yamada Yuta, Sugihara Toru, Kamei Jun, Sato Yusuke, Matsunaga Akiko, Yoshida Mikako, Shinoda Yusuke, Fukuhara Hiroshi, Nakagawa Tohru, Homma Yukio, Kume Haruki
    NEUROUROLOGY AND URODYNAMICS 38 4 1067 - 1075 2019年04月 [査読有り][通常論文]
     
    AIMS: To clarify longitudinal change of lower urinary tract symptoms (LUTS) and various types of urinary incontinence following robot-assisted radical prostatectomy (RARP) using validated questionnaires. MATERIALS AND METHODS: The core lower urinary tract symptom score (CLSS) and the International Consultation on Incontinence Questionnaire (ICIQ)-Short Form (SF) questionnaires were administered to 607 consecutive, treatment-naïve men receiving RARP before and after surgery. The time course of comprehensive LUTS and various types of urinary incontinence, including stress-, urgency-, and urinary incontinence with no obvious reason, were evaluated. Continence recovery rates were compared for the different types of incontinence using Cox hazard regression analysis. RESULTS: After surgery, stress urinary incontinence (SUI) was reported most frequently (32% of cases) as the chief complaint with the most impact on daily life, as assessed by the CLSS questionnaire, followed by urgency urinary incontinence (UUI; 27% of cases). The rates of continence recovery differed among the different types of urinary incontinence, such as after urinating, when dressed, when asleep, when physically active or exercising, when coughing or sneezing, before reaching the toilet, and for no obvious reason. Incontinence for no obvious reason at 1 month after RARP was a strongest prognostic factor of delayed continence recovery (hazard ratio, 0.61; P < 0.0001), whereas patients reporting SUI and UUI gradually regained continence. CONCLUSIONS: Further time course on continent recovery after RARP would be more precisely predictable based on the incontinence status at one month postoperatively. Especially, incontinence with no obvious reason would be a significant factor for delayed recovery.
  • 白川 昇英, 山田 大介, 大科 貴宏, 樋勝 政博, 塩澤 廸夫, 亀井 潤, 秋山 佳之, 佐藤 悠佑, 新美 文彩, 野宮 明, 中村 真樹, 川合 剛人, 高橋 さゆり, 松本 明彦, 藤村 哲也, 福原 浩, 久米 春喜, 井川 靖彦, 中川 徹, 本間 之夫
    泌尿器外科 32 2 199 - 199 医学図書出版(株) 2019年02月 [査読有り][通常論文]
  • Suzuki M, Miyazaki H, Kamei J, Yoshida M, Taniguchi T, Nishimura K, Igawa Y, Sanada H, Homma Y
    Neurourology and urodynamics 38 2 757 - 763 2019年02月 [査読有り][通常論文]
     
    AIMS: To determine whether ultrasound-assisted prompted voiding (USAPV) care is more efficacious than conventional prompted voiding (CPV) care for managing urinary incontinence in nursing homes. METHODS: Thirteen participating nursing homes in Japan were randomized to CPV (n = 7) or USAPV care group (n = 6). Residents of the allocated nursing homes received CPV (n = 35) or USAPV (n = 45) care for 8 weeks. In the CPV group, caregivers asked the elderly every 2-3 h whether they had a desire to void and prompted them to void when the response was yes. In the USAPV group, caregivers regularly monitored bladder urine volume by an ultrasound device and prompted them to void when the volume reached close to the individually optimized bladder capacity. Frequency-volume chart was recorded at the baseline and after the 8-week intervention to measure the daytime urine loss. RESULTS: The change in daytime urine loss was statistically greater in the USAPV (median, -80.0 g) than in the CPV (median, -9.0 g; P = .018) group. The proportion of elderly individuals whose daytime urine loss decreased by >25% was 51% and 26% in the USAPV and CPV group, respectively (P = .020). Quality-of-life measures of elderly participants showed no significant changes in both groups. The care burden scale score of caregivers was unchanged in the USAPV group (P = .59) but significantly worsened in the CPV group (P = .010) after the intervention. CONCLUSIONS: USAPV is efficacious and feasible for managing urinary incontinence in nursing homes.
  • Sugihara T, Yasunaga H, Matsui H, Kamei J, Fujimura T, Kume H
    International journal of urology : official journal of the Japanese Urological Association 26 2 303 - 305 2019年02月 [査読有り][通常論文]
  • 亀井 潤, 小柳 礼恵, 佐々木 早苗, 河崎 明子, 松永 明子, 久米 春喜
    日本老年泌尿器科学会誌 31 78 - 78 日本老年泌尿器科学会 2018年11月
  • Kamei J, Aizawa N, Nakagawa T, Kaneko S, Kume H, Homma Y, Igawa Y
    Scientific Reports 8 1 15622 - 15622 2018年10月 [査読有り][通常論文]
     
    Transient receptor potential ankyrin 1 (TRPA1) channel expressed by urothelial cells and bladder sensory nerve fibers might act as a bladder mechanosensor and nociceptive transducer. To disclose the role of TRPA1 in bladder function and inflammation-associated hypersensitivity, we evaluated in vitro and in vivo bladder function and inflammatory mechanosensory and nociceptive responses to intravesical lipopolysaccharide (LPS)-instillation in wild type (WT) and TRPA1-knock out (KO) mice. At baseline before treatment, no significant differences were observed in frequency volume variables, in vitro detrusor contractility, and cystometric parameters between the two groups in either sex. LPS-instillation significantly increased voiding frequency and decreased mean voided volume at 24-48 hours after instillation in WT but not in TRPA1-KO mice. LPS-instillation also significantly increased the number of pain-like behavior at 24 hours after instillation in WT mice, but not in TRPA1-KO mice. Cystometry 24 hours after LPS-instillation revealed shorter inter-contraction intervals in the WT mice compared with TRPA1-KO mice. In contrast, inflammatory cell infiltration in the bladder suburothelial layer was not significantly different between the two groups. These results indicate that TRPA1 channels are involved in bladder mechanosensory and nociceptive hypersensitivity accompanied with inflammation but not in physiological bladder function or development of bladder inflammation.
  • 排尿自立指導による排尿自立度と下部尿路機能障害の改善効果 泌尿器科以外の病棟における介入効果の検討
    亀井 潤, 小柳 礼恵, 佐々木 早苗, 河崎 明子, 松永 明子, 井川 靖彦, 久米 春喜
    日本排尿機能学会誌 29 1 264 - 264 (一社)日本排尿機能学会 2018年09月
  • Jun Kamei, Satoshi Yazawa, Shingo Yamamoto, Naoto Kaburaki, Satoru Takahashi, Masami Takeyama, Masayasu Koyama, Yukio Homma, Soichi Arakawa, Hiroshi Kiyota
    Neurourology and Urodynamics 37 3 1074 - 1081 2018年03月 [査読有り][通常論文]
     
    Aims: We conducted a nationwide survey on perioperative management and antimicrobial prophylaxis of transvaginal mesh surgeries for pelvic organ prolapse in Japan to understand the practice and risk factors for surgical site infection (SSI). Methods: Health records of women undergoing tension-free vaginal mesh (TVM) surgeries from 2010 to 2012 were obtained from 135 medical centers belonging to the Japanese Society of Pelvic Organ Prolapse Surgery. The questionnaire addressed hospital volume, perioperative management, and SSI. Risk factors for SSI were investigated by comparing cases with and without SSI. Results: The hospital volume among institutions varied from 0 to 248 per year (median 16.7). Preoperative hair removal, bowel preparation, and urine culture were routinely performed at 74 (55%), 66 (49%), and 24 (18%) hospitals, respectively. Prophylactic antimicrobials used were mostly first-generation (43%) or second-generation (42%) cephalosporin. SSI was reported in 86 of 9323 patients (0.92%). A multivariate analysis indicated lower hospital volume (odds ratio [OR], 0.995 [by 1-point increase] P < 0.001), preoperative bowel preparation (OR, 2.08 P = 0.013), non-routine urine culture (OR, 3.00 P = 0.0006), and the use of antibiotics other than first-generation cephalosporin (OR, 5.29 P = 0.0011) as significant risk factors for SSI. In contrast, the cut-off points of hospital volume for preventing SSI was 116.7 cases (area under curve: 0.61). Conclusion: The prevalence of SSI in TVM surgeries was 0.92% in Japan. Lower hospital volume, bowel preparation, non-routine preoperative urine culture, and prophylactic antibiotics other than first-generation cephalosporin significantly elevated the incidence of SSI.
  • Aya Niimi, Yasuhiko Igawa, Naoki Aizawa, Toshiki Honma, Akira Nomiya, Yoshiyuki Akiyama, Jun Kamei, Tetsuya Fujimura, Hiroshi Fukuhara, Yukio Homma
    Neurourology and urodynamics 37 3 1113 - 1119 2018年03月 [査読有り][通常論文]
     
    AIM: To investigate the feasibility of chemokines and cytokines potentially elevated in the bladder tissue of Hunner type interstitial cystitis (HIC) as urinary markers for distinguishing HIC from non-Hunner type interstitial cystitis (NHIC) METHODS: Urine specimens were collected from 41 HIC patients, 25 NHIC patients, and 31 healthy volunteers (control). The supernatants of urine specimens were subjected to ELISA kits for measurements of 10 cytokines and chemokines, whose gene expression was known to be elevated in HIC bladder tissue. Urinary levels normalized by urinary creatinine (Cr) concentration were compared among three groups. Efficiency in differentiating IC and IC subtypes was explored by ROC analysis. The correlation of marker levels with symptom severity, assessed by O'Leary-Sant's symptom index (OSSI) and problem index (OSPI), was examined. RESULTS: The urinary levels of CXCL10 and NGF were significantly higher in HIC than NHIC. CXCL10 and NGF differentiated HIC against NHIC with AUC of 0.78 and 0.68, respectively. Combination of CXCL10 and NGF levels yielded an AUS of 0.81. The CXCL10 cut-off of 53.2 pg/mg Cr had sensitivity of 46.1%, specificity of 93.7%, positive predictive value of 97.7%, and negative predictive value of 60.0%. The urinary level of other cytokines showed no significant difference between HIC and NHIC. Significant correlation with symptoms was detected for CXCL10 alone. CONCLUSION: The results suggested that increased urinary level of CXCL10 combined with or without high NGF level could be a promising supplementary biomarker for differentiating HIC from NHIC with modest sensitivity and high specificity.
  • Jun Kamei, Hiroki Ito, Naoki Aizawa, Harumi Hotta, Toshio Kojima, Yasunori Fujita, Masafumi Ito, Yukio Homma, Yasuhiko Igawa
    Scientific reports 8 1 2089 - 2089 2018年02月 [査読有り][通常論文]
     
    We investigated age-related changes in in vivo and in vitro functions and gene expression of the bladder of male and female mice. Mature and aged (12 and 27-30 month old) C57BL/6 mice of both sexes were used. Frequency volume, conscious free-moving cystometry and detrusor contractile and relaxant properties in in vitro organ bath were evaluated. mRNA expression level of muscarinic, purinergic, and β-adrenergic receptors and gene expression changes by cDNA microarray analysis of the bladder were determined. Cystometry demonstrated storage and voiding dysfunctions with ageing in both sexes. Detrusor strips from aged mice showed weaker contractile responses particularly in the cholinergic component and weaker relaxant responses to isoproterenol. These age-related impairments were generally severer in males. mRNA expression of bladder tissue was decreased for M3 muscarinic receptors in aged males and β2-adrenoceptors in aged females. cDNA microarray analysis results, albeit substantial sex difference, indicated "cell-to-cell signaling and interaction" as the most common feature of age-related gene expression. In summary, aged mice demonstrated voiding and storage dysfunctions resembling to detrusor hyperactivity with impaired contractility (DHIC), which were more pronounced in males. Genomic changes associated with aging may contribute to the age-related bladder functional deterioration in mice.
  • Jun Kamei, Hiroshi Yabu
    SOFT MATTER 13 43 7834 - 7839 2017年11月 [査読有り][通常論文]
     
    Highly ordered porous films whose pore size ranges from submicron to micron scale have always been an extensive area of research due to their broad range of application to photonic crystals, cell culturing scaffolds, filtration and separation membranes, just to name a few. However, the fragile nature of such a functional porous film has hindered its implementation to advanced uses. Inspired by the hierarchic structure in nature which offers both robustness and functionality, we created in a single fabrication step a mesh-reinforced hierarchic perforated honeycomb film with highly ordered micron pores using the breath figure method. By using the elastomer 1,2-polybutadiene as the material for the film in the combination of the mesh grid, the pore size of the obtained film can be tuned upon stretching. Tubular structures made from the mesh-reinforced hierarchic perforated porous honeycomb film with tunable pore size have been demonstrated.
  • Koji Ichihara, Naoki Aizawa, Yoshiyuki Akiyama, Jun Kamei, Naoya Masumori, Karl-Erik Andersson, Yukio Homma, Yasuhiko Igawa
    PAIN 158 8 1538 - 1545 2017年08月 [査読有り][通常論文]
     
    Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjo "gren syndrome, wellknown diseases accompanying interstitial cystitis (IC). We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and nociception using mice. Bladder biopsy specimens were obtained from patients with HIC. Specimens from the noncancerous portion of the bladder of patients with bladder cancer served as controls. The specimens were examined by immunohistochemistry and real-time polymerase chain reaction of TLR7. Loxoribine (LX), a TLR7 agonist, was instilled in the bladder of C57BL/6N female mice, and TLR7-mRNA expression and histological changes of the bladder, bladder pain-like licking behavior, voiding behavior, cystometry, and bladder afferent nerve activities were investigated. The effects of hydroxychloroquine, a TLR7 antagonist, on the LX-induced changes on cystometry and voiding behavior were studied. The number of TLR7 immuno-reactive cells and the mRNA expression of TLR7 were significantly increased in HIC specimens. Intravesical instillation of LX induced edema, congestion, inflammation, and significantly increased TLR7-mRNA expression in the mouse bladder. Loxoribine-instillation also significantly increased licking behavior, voiding frequency, and afferent nerve activities associated with decreased single-voided volume and intercontraction interval of micturitions. Hydroxychloroquine reversed the LXinduced cystometric and voiding behavioral changes. Toll-like receptor 7 was up-regulated in the bladder mucosa of patients with HIC, and activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder. Blocking the TLR7 pathway may be an innovative treatment target of HIC.
  • Jun Kamei, Yuka Yagihara, Haruki Kume, Takamasa Horiuchi, Tomoaki Sato, Tohru Nakagawa, Tetsuya Fujimura, Hiroshi Fukuhara, Kyoji Moriya, Yukio Homma
    INTERNATIONAL JOURNAL OF UROLOGY 24 4 295 - 300 2017年04月 [査読有り][通常論文]
     
    ObjectivesTo examine resistant Escherichia coli in rectal swab culture of Japanese men undergoing prostate biopsy, and to determine its prevalence, genotypic characteristics and carriage risk factors. MethodsRectal swabs of consecutive men undergoing transrectal ultrasound-guided prostate biopsy from April 2013 to March 2015 were cultured to isolate fluoroquinolone-resistant and extended-spectrum -lactamase-producing E. coli. The prevalence and antimicrobial susceptibility of these resistant E. coli strains and extended-spectrum -lactamase genotyping were examined. The risk factors of antimicrobial resistance carriage were also examined. ResultsThe cohort was 376 men with a mean age of 67.8 years. Fluoroquinolone-resistant E. coli and extended-spectrum -lactamase-producing E. coli were detected in 37 men (9.8%) and 22 men (5.9%), respectively, with fluoroquinolone-resistant and/or extended-spectrum -lactamase-producing E. coli in 48 men (13.0%). All 49 antimicrobial-resistant strains were susceptible to tazobactam/piperacillin, amikacin, fosfomycin, meropenem and faropenem. CTX-M-9 and CTX-M-1 group were detected in 14 (63.6%) and eight (36.4%) men, respectively. CTX-M-9 showed relatively higher susceptibility to LVFX and minocycline compared with CTX-M-1. Diabetes mellitus was a significant factor for carriage of resistance by multivariate analysis (odds ratio 2.12, P = 0.039). ConclusionsThe present study showed the fecal carriage of fluoroquinolone-resistant E. coli and extended-spectrum -lactamase-producing E. coli at 9.8% and 5.9%, respectively, with CTX-M-9 group of extended-spectrum -lactamase-producing E. coli comprising 63.6%, in Japanese men receiving prostate biopsy. The carriage of fluoroquinolone-resistant and/or extended-spectrum -lactamase-producing E. coli was significantly related to diabetes.
  • Hiroshi Yabu, Jun Kamei
    BIOINSPIRATION, BIOMIMETICS, AND BIOREPLICATION 2017 10162 2017年 [査読有り][通常論文]
  • Jun Kamei, Hiroya Abe, Hiroshi Yabu
    LANGMUIR 33 2 585 - 590 2017年01月 [査読有り][通常論文]
     
    The adhesion of bubbles underwater remains the greatest cause of malfunctions in applications such as microfluidics, medical devices, and heat exchangers. Recently the combination of oxidization and peeling the top layer of self-organized honeycomb films with an adhesive tape resulted in the formation of an ultra-bubble-repellent and pillared polymer surface structure. However, the fabrication of honeycomb films on the inner, surface of tubes and the formation of structured hydrophilic textures by peeling the top layer of honeycomb films still remain problematic., In this report, a simple fabricatinn technique for producing a honeycomb-pattemed polymer film on the interior of a: tube by dip-coating a polymer solution and, blowing humid air in the tube is described Furthermore, an ultra-bubble, repellent dimple-arrayed structure was fabricated by applying ultrasonicatiorcto the honeyconib structure formed on the interior surface of the tubes.
  • Hiroki Ito, Jun Kamei, Naoki Aizawa, Yasunori Fujita, Motofumi Suzuki, Hiroshi Fukuhara, Tetsuya Fujimura, Toshio Kojima, Yukio Homma, Yoshinobu Kubota, Masafumi Ito, Karl-Erik Andersson, Yasuhiko Igawa
    JOURNAL OF UROLOGY 196 5 1575 - 1583 2016年11月 [査読有り][通常論文]
     
    Purpose: We evaluated aging related bladder dysfunctions and biological changes in the bladder and dorsal root ganglia in rats. We also investigated whether long-term caloric restriction may have preventive effects on these changes. Materials and Methods: Male Fischer 344 rats were divided into a young group (age 6 months) and an old group (age 25 to 28 months), each with free access to normal food, and an old group (age 25 to 28 months) with food restricted to 3 days per week. Conscious cystometry, cDNA microarray analysis, immunohistochemistry and oxidative stress measurements of the bladder and dorsal root ganglia were performed. Results: The old group with free access to normal food showed higher threshold pressure, more nonvoiding contractions and lower bladder compliance than the young group with free access to food. Old rats with free access showed greater post-void residual volume and lower voiding efficiency than old rats with caloric restriction and young rats. In the old group with free access 83 genes in the bladder and 48 in the L6 dorsal root ganglia were up-regulated compared with old rats with caloric restriction and young rats. These genes were mostly related to immune and inflammatory responses. Immunohistochemistry showed stronger expression of the immune response protease Gzm (granzyme) B and the collagenase Mmp13 (matrix metalloproteinase-13) in the bladder of old rats with free access vs old rats with caloric restriction and young rats. The level of malondialdehyde, an oxidative stress marker, was higher in the bladder of old rats with free access than in young rats but there was no difference between old rats with caloric restriction and young rats with free access to food. Conclusions: In rats aging leads to storage and voiding dysfunctions associated with immune and inflammatory related responses in the bladder and dorsal root ganglia, and with increased oxidative stress in the bladder. Caloric restriction reduced these aging related changes.
  • Yoshiyuki Akiyama, Daichi Maeda, Teppei Morikawa, Akira Nomiya, Yukio Yamada, Jun Kamei, Naoki Aizawa, Yasuhiko Lgawa, Masashi Fukayama, Yukio Homma
    JOURNAL OF UROLOGY 195 4 E952 - E952 2016年04月 [査読有り][通常論文]
  • Jun Kamei, Akira Furuta, Yoshiyuki Akiyama, Aya Niimi, Koji Ichihara, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yukio Homma, Yasuhiko Igawa
    INTERNATIONAL JOURNAL OF UROLOGY 22 10 956 - 961 2015年10月 [査読有り][通常論文]
     
    ObjectivesTo investigate video-urodynamic effects of mirabegron, a (3)-adrenoceptor agonist, on low-compliance bladder. MethodsWe retrospectively reviewed nine patients (three men, six women, age 17-68years) who had been diagnosed with lower urinary tract dysfunction with low-compliance bladder, and who underwent video-urodynamic study before and during administration of mirabegron 50mg once daily. Urodynamic parameters were compared before and after treatment. ResultsMirabegron treatment significantly increased first desire to void and cystometric capacity with an average increment of 80mL (P=0.027) and 123mL (P=0.005), respectively. Bladder compliance also significantly increased (mean value 8.1mL/cmH(2)O before, 18.2mL/cmH(2)O after, P=0.024). In the six patients who had been taking anticholinergic agents at baseline video-urodynamic study and then switched to mirabegron, mean cystometric capacity and bladder compliance were also increased significantly from 208.3 to 346.8mL (P=0.015) and from 7.2 to 17.5mL/cmH(2)O (P=0.047), respectively. Vesicoureteral reflux grade was improved in three of the four patients who had shown vesicoureteral reflux on cystography before treatment. ConclusionsMirabegron improves cystometric capacity and bladder compliance, and it lowers vesicoureteral reflux grade in patients with low-compliance bladder. Thus, mirabegron might represent a good alternative drug for low-compliance bladder refractory to anticholinergic treatment.
  • Kamei Jun, Yabu Hiroshi
    ADVANCED FUNCTIONAL MATERIALS 25 27 4195 - 4201 2015年07月 [査読有り][通常論文]
  • Hiroki Ito, Naoki Aizawa, Rino Sugiyama, Jun Kamei, Yoshiyuki Akiyama, Koji Ichihara, Yasunori Fujita, Toshio Kojima, Yukio Homma, Yoshinobu Kubota, Masafumi Ito, Karl-Erik Andersson, Yasuhiko Igawa
    JOURNAL OF UROLOGY 193 4 E75 - E75 2015年04月 [査読有り][通常論文]
  • Jun Kamei, Naoki Aizawa, Takayuki Nakagawa, Hiroki Ito, Rino Sugiyama, Yoshiyuki Akiyama, Koji Ichihara, Shuji Kaneko, Yukio Homma, Yasuhiko Igawa
    JOURNAL OF UROLOGY 193 4 E128 - E129 2015年04月 [査読有り][通常論文]
  • Toru Sugiahra, Hideo Yasunaga, Jun Kamei, Hiroki Matsui, Tohru Nakagawa, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Kiyohide Fushimi, Masaaki Tachibana, Yukio Homma
    JOURNAL OF UROLOGY 193 4 E230 - E230 2015年04月 [査読有り][通常論文]
  • Hiroshi Yabu, Kuniaki Nagamine, Jun Kamei, Yuta Saito, Taiki Okabe, Tatsuaki Shimazaki, Matsuhiko Nishizawa
    RSC Advances 5 88414 - 88418 2015年 [査読有り][通常論文]
  • Jun Kamei, Yuta Saito, Hiroshi Yabu
    LANGMUIR 30 47 14118 - 14122 2014年12月 [査読有り][通常論文]
     
    The adhesion of bubbles underwater remains the greatest cause of malfunctions in applications such as microfluidics, medical devices and heat exchangers. There is therefore an emerging need for ultra-bubble-repellent surfaces. Inspired by fish scales, which show high bubble repellency due to their hydrophilic nature and surface microstructures, we propose a novel method for preparing ultra-bubble-repellent surfaces by the hydrophilic treatment of self-organized microstructures. When in contact with air bubbles underwater, the artificial hydrophilic microstructured surfaces had a higher contact angle and a lower adhesion force than a flat surface. The mechanism leading to these properties is also investigated. Our method for the fabrication of ultra-bubble-repellent, hydrophilic, microstructured surfaces is simple and cost-effective, opening the way for its application in artificial devices, such as the inner surfaces of tubes, medical devices, and heat exchangers.
  • Jun Kamei, Hiroaki Nishimatsu, Tohru Nakagawa, Motofumi Suzuki, Tetsuya Fujimura, Hiroshi Fukuhara, Yasuhiko Igawa, Haruki Kume, Yukio Homma
    INTERNATIONAL UROLOGY AND NEPHROLOGY 46 3 493 - 497 2014年03月 [査読有り][通常論文]
     
    To assess the risk factors for septic shock in patients with acute obstructive pyelonephritis requiring emergency drainage of the upper urinary tract. We retrospectively reviewed the records of 48 patients who underwent emergency drainage of the upper urinary tract for sepsis associated with acute obstructive pyelonephritis at our institute. Univariate and multivariate analyses were performed to identify the risk factors. Among 54 events of sepsis, we identified 20 events of septic shock requiring vasopressor therapy. Cases with shock were more likely than those without shock to have ureteral stone (70 vs 38 %, p = 0.024) and positive blood culture results (81 vs 28 %, p = 0.006). They received drainage significantly earlier than those without shock (1.0 vs 3.5 days, p < 0.001). Univariate analysis demonstrated that acute obstructive pyelonephritis by ureteral stone, rapid progression (the occurrence of symptoms to drainage a parts per thousand currency sign1 day), positive blood culture, leukocytopenia (< 4,000/mm(3)), thrombocytopenia (< 120,000/mm(3)), and prothrombin time international normalized ratio a parts per thousand yen1.20 were correlated with septic shock. Multivariate logistic regression analysis identified thrombocytopenia (p = 0.005) and positive blood culture (p = 0.040) as independent risk factors for septic shock. Thrombocytopenia and positive blood culture were independent risk factors for septic shock in acute obstructive pyelonephritis requiring emergency drainage. Thrombocytopenia would be practically useful as a predictor of septic shock.
  • Jun Kamei, Yoko Kyono, Yukio Yamada, Mitsuru Shinohara, Yukio Homma
    Acta Urologica Japonica 58 7 361 - 364 2012年07月 [査読有り][通常論文]
     
    A 32-year-old man, who had been diagnosed with left testicular tumor and treated surgically at 30 years old, was diagnosed with recurrence of the testicular tumor by the elevation of tumor markers and para-aortic lymph node enlargement on computerized tomography. At the same time, creatine kinase was extremely elevated and he was diagnosed with polymyositis (PM). After systemic chemotherapy, the tumor markers improved. The symptoms of myopathy, however, became so severe that he developed aspiration pneumonia and required the temporary use of a ventilator. Using intravenous immunoglobulin and steroid pulse, the symptoms of PM improved. After the third chemotherapy session, the testicular tumor was in complete remission and he had no symptoms of polymyositis. After follow up for 7 years, there was no sign of recurrence of either testicular tumor or PM.
  • Jun Kamei, Hiroaki Nishimatsu, Haruki Kume, Motofumi Suzuki, Tetsuya Fujimura, Hiroshi Fukuhara, Yutaka Enomoto, Akira Ishikawa, Yasuhiko Igawa, Yukio Homma
    JOURNAL OF UROLOGY 187 4 E369 - E370 2012年04月 [査読有り][通常論文]
  • Jun Kamei, Haruki Kume, Motofumi Suzuki, Tetsuya Fujimura, Hiroshi Fukuhara, Yutaka Enomoto, Hiroaki Nishimatsu, Akira Ishikawa, Yasuhiko Igawa, Yukio Homma
    Japanese Journal of Urology 103 1 18 - 21 2012年 [査読有り][通常論文]
     
    A 76-year-old man underwent high orchiectomy due to a painless tumor in the left inguinal region. Pathological diagnosis was malignant fibrous histiocytoma (MFH) of the left spermatic cord. Because of positive surgical margins, additional resection of the left scrotal wall and left inguinal canal combined with retroperitoneal lymphadenectomy were performed, with the surgical margins negative. Adjuvant therapy was not administered. Eight years later he noticed a painful subcutaneous mass in the left inguinal region. CT showed local recurrence and metastases of MFH to mesenteric lymph nodes and the left adrenal gland. The tumor grew rapidly and the patient died 1 month after admission. Autopsy revealed local recurrence of MFH and metastases of MFH to liver, lung, left adrenal gland, bone and lymph nodes. Recurrence of MFH with an interval of 8 years is a rare event. © 2012 Japanese Urological Association.

MISC

  • 亀井 潤 Uro-Lo: 泌尿器Care & Cure 26 (5) 637 -641 2021年10月 
    ▼単純性膀胱炎は、尿路や全身に基礎疾患がない性的活動期の女性に多く発症する。▼頻尿、排尿時痛、残尿感などの膀胱刺激症状が出現し、発熱を伴わないのが特徴である。▼適切な抗菌薬での治療と同時に、再発しないような生活指導を行うことが大切である。(著者抄録)
  • 横山 博崇, 安東 聡, 早瀬 貴徳, 茗荷 宏昭, 山崎 正博, 小松原 麻衣子, 亀井 潤, 杉原 亨, 藤崎 明, 高山 達也, 藤村 哲也 泌尿器外科 34 (9) 1101 -1105 2021年09月 
    無痛性左陰嚢内容腫大と頸部、縦隔、左腋窩、傍大動脈リンパ節腫大、頭蓋内腫瘍のある80歳男性。全身状態が不良であったため、腋窩リンパ節生検を先行した。病理診断はDiffuse large B-cell lymphoma(DLBCL)。一元的に精巣原発DLBCLが疑われた。R-CHOP療法後、リンパ節は消失もしくは縮小した。残存する精巣腫瘍に対して左高位精巣摘除術を施行。病理は奇形腫を伴う高分化神経内分泌腫瘍であった。(著者抄録)
  • 前立腺肥大症患者のTransitional zone indexはデュタステリド内服6ヵ月後の自覚所見改善の予測因子になる
    亀井 潤, 黒川 真輔, 杉原 亨, 藤崎 明, 安東 聡, 高山 達也, 藤村 哲也 日本排尿機能学会誌 32 (1) 184 -184 2021年09月
  • 当院におけるロボット支援仙骨腟固定術の初期経験
    亀井 潤, 山崎 正博, 秋元 隆宏, 横山 博隆, 杉原 亨, 藤崎 明, 安藤 聡, 藤村 哲也 日本女性骨盤底医学会プログラム・抄録集 23回 113 -113 2021年07月
  • 亀井 潤 腎と透析 90 (6) 988 -992 2021年06月
  • 審査腹腔鏡により診断し得た膀胱癌腹膜播種の1例
    矢崎 海, 杉原 亨, 茗荷 宏昭, 山崎 正博, 小松原 麻衣子, 亀井 潤, 藤崎 明, 安東 聡, 高山 達也, 藤村 哲也 泌尿器外科 34 (臨増) 780 -780 2021年06月
  • 秋元 隆宏, 藤崎 明, 横山 博崇, 山崎 正博, 亀井 潤, 杉原 亨, 安東 聡, 高山 達也, 久米 春喜, 藤村 哲也 日本老年泌尿器科学会誌 34 (1) 125 -125 2021年04月
  • 【過活動膀胱-進む病態解明と広がる治療選択肢】疫学・病態・QOL
    亀井 潤 カレントテラピー 39 (2) 118 -123 2021年02月 
    過活動膀胱(overactive bladder:OAB)は、「尿意切迫感を必須とした症状症候群であり、通常は頻尿と夜間頻尿を伴うもの」と定義される。その有症状率はわが国の疫学調査によると40歳以上の男女の12.8%に上り、男女ともに加齢とともに増加し、近年の人口構成に当てはめると国内の推定患者は1,000万人以上になる。OABが発症するメカニズムはいまだ十分に解明されていないが、明らかに神経疾患に起因する神経因性OABと神経学的な異常がない非神経因性OABに二分される。近年の研究により、非神経因性OABは膀胱の血流障害、自律神経系の活動亢進、炎症、加齢などが関与することが明らかになり、メタボリック症候群との関連も示唆されている。直接生命にかかわる疾患ではないが、不快な蓄尿症状により生活の質(QOL)を著しく損なう疾患であるため、適切な啓蒙と治療介入が重要である。(著者抄録)
  • 亀井 潤 臨床泌尿器科 74 (13) 1048 -1051 2020年12月 
    <文献概要>ポイント ・尿路検査では,尿路に対する無菌操作と適切な滅菌器具の使用を心がける.・尿は感染性のある体液なので,手指衛生と個人防護具の使用を徹底する.・上部尿路に対する検査では,可能な限りmaximal barrier precautionsにて行うことが望ましい.
  • 陰茎折症9例の臨床的特徴
    亀田 智弘, 高山 達也, 山崎 正博, 小松原 麻衣子, 亀井 潤, 杉原 亨, 藤崎 明, 安東 聡, 藤村 哲也, 坂田 浩一 日本性機能学会雑誌 35 (3) 117 -121 2020年12月 
    【目的】当院で経験した陰茎折症9例の臨床的特徴を報告する。【対象と方法】1999年5月から2015年6月まで陰茎折症と診断された9例を対象とした。診療録から患者背景、受傷機転、身体所見、画像検査結果、手術所見、術後合併症を調査した。【結果】年齢の中央値は45歳(28-66)だった。受傷機転は性交中の受傷が5例(55.6%)と最も多かった。身体所見としては陰茎の屈曲、腫脹は全例に認め、陰茎の断裂音は5例(55.6%)に認めた。全例で緊急手術を行い、白膜断裂部位の修復を行った。受傷から手術までの時間の中央値は6時間(3-24)であった。陰茎近位での損傷が4例(44.4%)と最も多く、陰茎海綿体の損傷は右側が7例(77.8%)と最も多かった。術後経過観察期間の中央値は26日間(1-286)で、重篤な術後合併症は認めず、観察期間の範囲では勃起不全を合併した症例も認めなかった。【結語】陰茎折症の9例の臨床的特徴を報告した。(著者抄録)
  • 根治切除不能又は転移性の腎細胞癌に対するイピリムマブ・ニボルマブ併用療法の有効性と安全性の検討
    安東 聡, 茗荷 宏昭, 竹嶋 咲, 山崎 正博, 亀田 智弘, 小松原 麻衣子, 亀井 潤, 杉原 亨, 藤崎 明, 高山 達也, 藤村 哲也 日本泌尿器科学会総会 108回 1784 -1784 2020年12月
  • 松永 明子, 吉田 美香子, 佐藤 悠佑, 亀井 潤, 新美 文彩, 藤村 哲也, 篠田 祐介, 久米 春喜, 井川 靖彦 日本創傷・オストミー・失禁管理学会誌 24 (2) 123 -123 2020年07月
  • 茗荷 宏昭, 山崎 正博, 亀井 潤, 杉原 亨, 竹嶋 咲, 亀田 智弘, 眞弓 翔三郎, 藤崎 明, 安東 聡, 高山 達也, 藤村 哲也 泌尿器外科 33 (5) 545 -545 2020年05月
  • 亀井 潤 泌尿器外科 33 (2) 133 -137 2020年02月 
    尿路結石などによる急性閉塞性腎盂腎炎は泌尿器科医が遭遇する比較的頻度の高い重症尿路感染症である。本疾患では、診断後は速やかに広域スペクトラム抗菌薬の投与を開始して、尿路ドレナージを行う必要がある。しかし適切な管理を行っても、治療経過中に敗血症性ショック、死亡に至る割合は、それぞれ20.5〜33.3%、0〜7.4%とも言われており、急速に重症化する可能性がある疾患であることを念頭に置くべきである。敗血症性ショックや死亡の危険因子を正しく把握することで、治療成績の向上や、入院日数の短縮を目指すことが重要である。(著者抄録)
  • 亀井 潤 臨床泌尿器科 73 (12) 916 -919 2019年11月 
    <文献概要>ポイント ・患者の症状や不安,生活への支障の程度を考えながら,適切な検査や治療を提案する.・診療を通じて,患者自身が疾患や自分の症状を理解し,セルフマネジメントできるように指導する.・症状が軽度の場合は,検査や治療を開始せず経過観察することも1つの選択肢である.
  • 次世代が語るLUTD研究の未来像 加齢と下部尿路機能
    亀井 潤, 伊藤 悠城, 相澤 直樹, 井川 靖彦 日本排尿機能学会誌 30 (1) 137 -137 2019年09月
  • 亀田 智弘, 眞弓 翔三郎, 茗荷 宏昭, 竹嶋 咲, 山崎 正博, 小松原 麻衣子, 亀井 潤, 杉原 亨, 藤崎 明, 安東 聡, 坂田 浩一, 高山 達也, 藤村 哲也 日本性機能学会雑誌 34 (2) 159 -159 2019年08月
  • 山崎 正博, 亀田 智弘, 森田 侑平, 竹嶋 咲, 田畑 憲一, 池 大官, 田代 絢亮, 亀井 潤, 杉原 亨, 藤崎 明, 安東 聡, 高山 達也, 福嶋 敬宜, 藤村 哲也 泌尿器外科 32 (7) 971 -974 2019年07月 [査読有り][通常論文]
     
    48歳男性。陰嚢腫大、陰嚢皮膚からの出血のため救急搬送された。精査にて骨盤内、鼠径リンパ節転移を伴う右精巣腫瘍(cT4N3M1aS2)と診断した。また右下肢に蜂窩織炎を認め、炎症反応が著しく高かった。局所進行が強く高位精巣摘除術が困難であり、リンパ節生検を施行した上で化学療法を施行した。生検結果はセミノーマであった。腫瘍の縮小が得られ、高位精巣摘除術、リンパ節郭清術、腹直筋皮弁による閉創を施行した。術後10ヵ月再発なく経過している。(著者抄録)
  • 亀井 潤, 藤村 哲也 Pharma Medica 37 (6) 55 -58 2019年06月
  • 藤村 哲也, 亀井 潤, 新美 文彩, 佐藤 悠佑, 山田 雄太, 杉原 亨, 相澤 直樹, 中川 徹, 福原 浩, 井川 靖彦, 久米 春喜 泌尿器外科 32 (臨増) 759 -759 2019年06月
  • 東京大学医学部附属病院における仙骨神経刺激療法の初期経験
    亀井 潤, 松井 甫雄, 渡邉 大仁, 鈴木 基文, 藤村 哲也, 井川 靖彦, 久米 春喜 日本泌尿器科学会総会 107回 OP -401 2019年04月
  • 自治医科大学におけるロボット支援根治的膀胱全摘除術の治療成績
    杉原 亨, 高山 達也, 竹嶋 咲, 山崎 正博, 亀田 智弘, 亀井 潤, 藤崎 明, 安東 聡, 黒川 真輔, 藤村 哲也 日本泌尿器科学会総会 107回 PP2 -110 2019年04月
  • 根治切除不能又は転移性の腎細胞癌に対するニボルマブ投与の有効性と安全性の検討
    安東 聡, 竹嶋 咲, 山崎 正博, 亀田 智弘, 小松原 麻衣子, 亀井 潤, 杉原 亨, 藤崎 明, 黒川 真輔, 高山 達也, 藤村 哲也 日本泌尿器科学会総会 107回 PP3 -176 2019年04月
  • 山崎 正博, 黒川 真輔, 亀田 智弘, 金子 侑平, 竹嶋 咲, 田畑 憲一, 池 大官, 田代 絢亮, 亀井 潤, 杉原 亨, 藤崎 明, 安東 聡, 高山 達也, 福嶋 敬宜, 藤村 哲也 泌尿器外科 32 (3) 305 -305 2019年03月 [査読無し][通常論文]
  • 【泌尿器系疾患と慢性炎症】慢性膀胱炎の病態と治療
    亀井 潤 別冊Bio Clinica: 慢性炎症と疾患 7 (4) 37 -40 2018年12月 
    慢性膀胱炎は、尿路の基礎疾患を背景とした複雑性尿路感染症である。原因菌はグラム陰性桿菌が中心となるが多岐にわたり、薬剤耐性菌の頻度も高い。尿路基礎疾患による尿路上皮の破綻や尿路内異物による細菌バイオフィルムの形成がその病因となるため、治療には背景にある尿路基礎疾患の除去を同時に行う必要がある。無症状の場合は安易な抗菌薬の投与は避けて、有症状の場合にのみ複雑性膀胱炎治療に準じた抗菌薬治療を行う。膀胱留置カテーテルが挿入されている場合は、可能であれば抜去し、不可能な場合でも新しいものと交換する。急性増悪による症状性感染を予防する様に、心がけることが肝要である。(著者抄録)
  • 増田 稔, 亀井 潤, 村岡 亜紀, 久米 春喜 日本老年泌尿器科学会誌 31 83 -83 2018年11月
  • ロボット支援腹腔鏡下前立腺全摘除術後の尿禁制回復に対する、経会陰超音波画像を用いた術前骨盤底リハビリテーションの有効性検証
    吉田 美香子, 松永 明子, 井川 靖彦, 藤村 哲也, 篠田 裕介, 佐藤 悠佑, 亀井 潤, 新美 彩, 相澤 直樹, 本間 之夫, 芳賀 信彦, 久米 春喜, 真田 弘美 日本排尿機能学会誌 29 (1) 198 -198 2018年09月 [査読無し][通常論文]
  • 排尿自立指導による排尿自立度と下部尿路機能障害の改善効果 泌尿器科以外の病棟における介入効果の検討
    亀井 潤, 小柳 礼恵, 佐々木 早苗, 河崎 明子, 松永 明子, 井川 靖彦, 久米 春喜 日本排尿機能学会誌 29 (1) 264 -264 2018年09月 [査読無し][通常論文]
  • ロボット支援腹腔鏡下前立腺全摘除術後の尿禁制回復に対する、経会陰超音波画像を用いた術前骨盤底リハビリテーションの有効性検証
    吉田 美香子, 松永 明子, 井川 靖彦, 藤村 哲也, 篠田 裕介, 佐藤 悠佑, 亀井 潤, 新美 彩, 相澤 直樹, 本間 之夫, 芳賀 信彦, 久米 春喜, 真田 弘美 日本排尿機能学会誌 29 (1) 198 -198 2018年09月 [査読無し][通常論文]
  • 実践マニュアル 排尿自立指導料
    亀井 潤 Urology Today 25 (3) 182 -186 2018年08月 [査読無し][通常論文]
  • 実践マニュアル 排尿自立指導料
    亀井 潤 Urology Today 25 (3) 182 -186 2018年08月
  • 埼玉県における小児在宅医療の病診連携 非小児科医が行う小児在宅医療の臨床的検討
    矢澤 聰, 奈倉 道明, 山中 崇, 関 茂樹, 亀井 潤, 金井 稔, 中原 仁 日本在宅医学会大会 20回 222 -222 2018年04月 [査読無し][通常論文]
  • なだらかな在宅緩和ケア移行を経て自宅で看取った独居の前立腺癌の1例
    矢澤 聰, 加藤 裕二, 山中 崇, 小川 一栄, 亀井 潤, 菊野 伸之, 中原 仁, 佐藤 聡 泌尿器外科 31 (4) 451 -451 2018年04月 [査読無し][通常論文]
  • ハンナ型間質性膀胱炎に対する神経障害性疼痛関連物質であるリゾリン脂質の関与
    新美 文彩, 竹村 光太郎, 山田 幸央, 亀井 潤, 秋山 佳之, 野宮 明, 井川 靖彦, 本間 之夫 日本泌尿器科学会総会 106回 OP -418 2018年04月 [査読無し][通常論文]
  • 当院におけるMRI-TRUS fusionガイド下前立腺生検の初期経験
    樋勝 政博, 中村 真樹, 大科 貴宏, 白川 昇英, 高橋 潤, 塩澤 迪夫, 亀井 潤, 熊谷 仁平, 山田 大介, 藤村 哲也, 福原 浩, 本間 之夫 日本泌尿器科学会総会 106回 PP3 -181 2018年04月 [査読無し][通常論文]
  • 当院におけるMRI-TRUS fusionガイド下前立腺生検の初期経験
    樋勝 政博, 中村 真樹, 大科 貴宏, 白川 昇英, 高橋 潤, 塩澤 迪夫, 亀井 潤, 熊谷 仁平, 山田 大介, 藤村 哲也, 福原 浩, 本間 之夫 日本泌尿器科学会総会 106回 PP3 -181 2018年04月
  • ハンナ型間質性膀胱炎に対する神経障害性疼痛関連物質であるリゾリン脂質の関与
    新美 文彩, 竹村 光太郎, 山田 幸央, 亀井 潤, 秋山 佳之, 野宮 明, 井川 靖彦, 本間 之夫 日本泌尿器科学会総会 106回 OP -418 2018年04月 [査読無し][通常論文]
  • 吉田 美香子, 松永 明子, 藤村 哲也, 篠田 裕介, 新美 文彩, 亀井 潤, 相澤 直樹, 本間 之夫, 井川 靖彦, 真田 弘美 日本老年泌尿器科学会誌 30 51 -51 2018年03月 [査読無し][通常論文]
  • 亀井 潤, 井川 靖彦 Modern Physician 37 (12) 1241 -1243 2017年12月 [査読無し][通常論文]
     
    <ポイント>下部尿路症状(LUTS)は、直接生命にかかわるものではないがQOLを著しく障害する。男女共に年齢の上昇に伴い、LUTSの頻度は増加する。60歳以上の約78%が何らかのLUTSを有している。高齢者に特徴的な尿失禁として、溢流性尿失禁や機能性尿失禁がある。尿失禁、おむつの使用は、70歳以降急激に増加しており、施設入所高齢者の尿失禁有病率は高い。(著者抄録)
  • ハンナ型間質性膀胱炎に対する神経障害性疼痛関連物質であるリゾフォスファチジルコリンの関与
    新美 文彩, 山田 幸央, 竹村 光太郎, 野宮 明, 秋山 佳之, 亀井 潤, 相澤 直樹, 井川 靖彦, 本間 之夫 日本排尿機能学会誌 28 (1) 187 -187 2017年09月 [査読無し][通常論文]
  • 膀胱用超音波診断装置Liliumα-200による定時膀胱容量測定の妥当性 ビデオウロダイナミクス検査との比較検討
    亀井 潤, 秋山 佳之, 渡邉 大仁, 松井 甫雄, 藤村 哲也, 福原 浩, 井川 靖彦 日本排尿機能学会誌 28 (1) 242 -242 2017年09月 [査読無し][通常論文]
  • 間質性膀胱炎患者における細菌性膀胱炎に関する検討
    野宮 明, 田畑 真梨子, 山本 幸, 本田 圭, 依田 憲治, 亀井 潤, 秋山 佳之, 新美 文彩, 飯田 勝之, 榎本 裕, 井川 靖彦, 本間 之夫 日本泌尿器科学会総会 105回 OP09 -7 2017年04月 [査読無し][通常論文]
  • 膀胱炎症性疼痛におけるTransient receptor potential(TRP)A1チャネルの役割 ノックアウトマウスを用いた検討
    亀井 潤, 相澤 直樹, 中川 貴之, 金子 周司, 本間 之夫, 井川 靖彦 日本泌尿器科学会総会 105回 OP33 -4 2017年04月 [査読無し][通常論文]
  • 上部尿路結石に伴う閉塞性腎盂腎炎の検討
    松澤 幸正, 安達 英輔, 亀井 潤, 西松 寛明 日本化学療法学会雑誌 65 (Suppl.A) 372 -372 2017年03月 [査読無し][通常論文]
  • 亀井 潤, 本間 之夫 臨牀と研究 = The Japanese journal of clinical and experimental medicine 94 (2) 142 -146 2017年02月 [査読無し][通常論文]
  • 亀井 潤, 本間 之夫 臨牀と研究 94 (2) 142 -146 2017年02月 [査読無し][通常論文]
  • 頻尿を伴う炎症性膀胱痛に対するTransient receptor potential(TRP) M2およびTRPA1チャネルの役割 ノックアウトマウスを用いたLPS膀胱内注入による検討
    亀井 潤, 相澤 直樹, 中川 貴之, 秋山 佳之, 金子 周司, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 27 (1) 177 -177 2016年12月 [査読無し][通常論文]
  • 前立腺全摘術患者における超音波検査装置を用いた骨盤底リハビリテーションのフィージビリティ検討
    松永 明子, 吉田 美香子, 藤村 哲也, 篠田 裕介, 新美 文彩, 亀井 潤, 相澤 直樹, 真田 弘美, 芳賀 信彦, 井川 靖彦, 本間 之夫 日本排尿機能学会誌 27 (1) 207 -207 2016年12月 [査読無し][通常論文]
  • 間質性膀胱炎粘膜におけるTRPC1、4発現の検討
    野宮 明, 新美 文彩, 秋山 佳之, 亀井 潤, 藤村 哲也, 福原 浩, 榎本 裕, 井川 靖彦, 本間 之夫 日本排尿機能学会誌 27 (1) 217 -217 2016年12月 [査読無し][通常論文]
  • 間質性膀胱炎の経過中に低容量膀胱となった症例の臨床的検討
    新美 文彩, 秋山 佳之, 亀井 潤, 野宮 明, 山田 幸央, 井川 靖彦, 本間 之夫 日本排尿機能学会誌 27 (1) 219 -219 2016年12月 [査読無し][通常論文]
  • 前立腺全摘出術後の尿失禁重症度と骨盤底の形態・機能の関係 症例検討
    吉田 美香子, 松永 明子, 藤村 哲也, 篠田 裕介, 新美 文彩, 亀井 潤, 相澤 直樹, 井川 靖彦, 本間 之夫, 真田 弘美 日本排尿機能学会誌 27 (1) 261 -261 2016年12月 [査読無し][通常論文]
  • 田口 慧, 榎本 裕, 亀井 潤, 宮嵜 英世, 鈴木 基文, 藤村 哲也, 福原 浩, 西松 寛明, 石川 晃, 久米 春喜, 新谷 裕加子, 井川 靖彦, 本間 之夫 泌尿器外科 29 (6) 1055 -1055 2016年06月 [査読無し][通常論文]
  • 井川 靖彦, 亀井 潤 臨床泌尿器科 = Japanese journal of clinical urology 70 (6) 390 -396 2016年05月 [査読無し][通常論文]
  • 井川 靖彦, 亀井 潤 臨床泌尿器科 70 (6) 390 -396 2016年05月 [査読無し][通常論文]
     
    <ポイント>前立腺肥大症に対する薬物療法の目的は,下部尿路症状の軽減を通したQOL障害の改善および合併症予防と外科治療の回避である.主症状が何であるか(排尿症状,蓄尿症状,夜間頻尿)や,前立腺体積により,個々の症例に適した薬物選択が必要である.近年,PDE5阻害薬が登場したことで,治療選択肢の幅が広がっている.(著者抄録)
  • 前立腺生検患者の直腸スワブ培養から分離されたフルオロキノロン耐性大腸菌およびESBL産生大腸菌の頻度とその薬剤感受性の検討
    亀井 潤, 佐藤 智明, 森屋 恭爾, 八木原 由佳, 堀内 崇真, 中川 徹, 久米 春喜, 本間 之夫 日本化学療法学会雑誌 64 (Suppl.A) 175 -175 2016年05月 [査読無し][通常論文]
  • 亀井 潤, 井川 靖彦 泌尿器care & cure uro-lo : 治療と看護みんなつながるマガジン 21 (2) 179 -182 2016年04月 [査読無し][通常論文]
  • 亀井 潤, 井川 靖彦 泌尿器care & cure uro-lo : 治療と看護みんなつながるマガジン 21 (2) 272 -274 2016年04月 [査読無し][通常論文]
  • 亀井 潤, 井川 靖彦 Uro-Lo: 泌尿器Care & Cure 21 (2) 179 -182 2016年04月 [査読無し][通常論文]
  • 亀井 潤, 井川 靖彦 Uro-Lo: 泌尿器Care & Cure 21 (2) 272 -274 2016年04月 [査読無し][通常論文]
  • ここを狙え、排尿障害の基礎研究 膀胱知覚過敏に対する治療標的 TRPチャネル
    亀井 潤, 相澤 直樹, 本間 之夫, 井川 靖彦 日本泌尿器科学会総会 104回 PPS21 -2 2016年04月 [査読無し][通常論文]
  • 前立腺生検患者の直腸スワブ培養におけるフルオロキノロン耐性大腸菌およびESBL産生大腸菌の頻度とその関連因子
    堀内 崇真, 亀井 潤, 中川 徹, 久米 春喜, 松本 明彦, 宮嵜 英世, 藤村 哲也, 福原 浩, 佐藤 智明, 森屋 恭爾, 本間 之夫 日本泌尿器科学会総会 104回 PP3 -341 2016年04月 [査読無し][通常論文]
  • 松永 明子, 吉田 美香子, 横田 一彦, 亀井 潤, 新美 文彩, 相澤 直樹, 藤村 哲也, 篠田 裕介, 芳賀 信彦, 井川 靖彦, 本間 之夫 国立大学リハビリテーション療法士学術大会誌 37回 71 -75 2016年03月 [査読無し][通常論文]
     
    骨盤リハビリテーションで2ヵ月間の骨盤底筋訓練を完遂した腹圧性尿失禁患者12名(平均年齢65.9歳、経産婦8名)を対象に、訓練に抵抗性を示す患者の特徴を解析した。訓練後24時間パッドテストを行い、1日当たりのパッド使用枚数が0〜1枚の治癒群5名(41.7%)、2枚以上の非治癒群7名(58.3%)に分けて比較した。治癒群では非治癒群に比べ訓練終了時の尿失禁頻度、1回失禁量が少なく、尿失禁QOL質問票得点が有意に高かった。訓練開始前の状況では、非治癒群は治癒群に比べ軽度肥満者(BMI>25)、経産婦者の割合が多く、尿失禁頻度が2回以上/日が多い傾向であった。
  • 前立腺生検患者の直腸スワブ培養によるフルオロキノロン耐性大腸菌およびESBL産生大腸菌の頻度
    亀井 潤, 中川 徹, 久米 春喜, 松本 明彦, 宮嵜 英世, 藤村 哲也, 福原 浩, 佐藤 智明, 森屋 恭爾, 本間 之夫 日本腎泌尿器疾患予防医学研究会誌 24 (1) 73 -74 2016年03月 [査読無し][通常論文]
  • 雄性下部尿路閉塞ラットにおける膀胱伸展受容一次求心性神経活動の解析 膀胱微小収縮との関連性の検討
    杉山 梨乃, 相澤 直樹, 伊藤 悠城, 亀井 潤, 秋山 佳之, 市原 浩司, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 26 (1) 138 -138 2015年09月 [査読無し][通常論文]
  • β3作動薬ミラベグロンは低コンプライアンス膀胱に対してビデオウロダイナミクス所見を改善する
    亀井 潤, 古田 昭, 秋山 佳之, 新美 文彩, 市原 浩司, 藤村 哲也, 福原 浩, 久米 春喜, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 26 (1) 141 -141 2015年09月 [査読無し][通常論文]
  • 女性骨盤底障害患者に対する短期集中骨盤底筋訓練プログラムの成績
    松永 明子, 吉田 美香子, 藤村 哲也, 緒方 直史, 篠田 裕介, 新美 文彩, 亀井 潤, 相澤 直樹, 真田 弘美, 芳賀 信彦, 井川 靖彦, 本間 之夫 日本排尿機能学会誌 26 (1) 210 -210 2015年09月 [査読無し][通常論文]
  • Toll-like receptor(TLR)7の活性化はマウスにおいて頻尿・膀胱痛・膀胱炎を惹起しうる
    市原 浩司, 相澤 直樹, 杉山 梨乃, 伊藤 悠城, 亀井 潤, 秋山 佳之, 舛森 直哉, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 26 (1) 213 -213 2015年09月 [査読無し][通常論文]
  • ラット膀胱伸展受容一次求心性神経のAδおよびC線維の活動性に及ぼすresiniferatoxin脱感作の直接作用
    相澤 直樹, 伊藤 悠城, 杉山 梨乃, 亀井 潤, 秋山 佳之, 市原 浩司, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 26 (1) 216 -216 2015年09月 [査読無し][通常論文]
  • ハンナ型間質性膀胱炎の一部はB細胞のクローナル増殖を伴う慢性炎症・免疫疾患群である
    秋山 佳之, 前田 大地, 森川 鉄平, 新美 文彩, 野宮 明, 山田 幸央, 相澤 直樹, 杉山 梨乃, 亀井 潤, 伊藤 悠城, 市原 浩司, 藤村 哲也, 中川 徹, 福原 浩, 久米 春喜, 井川 靖彦, 深山 正久, 本間 之夫 日本排尿機能学会誌 26 (1) 219 -219 2015年09月 [査読無し][通常論文]
  • 杉山 梨乃, 相澤 直樹, 伊藤 悠城, 亀井 潤, 秋山 佳之, 市原 浩司, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 25 (2) 349 -350 2015年06月 [査読無し][通常論文]
  • 市原 浩司, 相澤 直樹, 杉山 梨乃, 伊藤 悠城, 亀井 潤, 秋山 佳之, 舛森 直哉, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 25 (2) 353 -353 2015年06月 [査読無し][通常論文]
  • 尿路感染症治療のベスト・プラクティスを提案する 排尿障害に伴う尿路感染症治療のベスト・プラクティスは?
    亀井 潤, 中川 徹, 久米 春喜, 井川 靖彦, 本間 之夫 日本化学療法学会雑誌 63 (Suppl.A) 112 -112 2015年05月 [査読無し][通常論文]
  • 除脳マウスにおいてToll like receptor(TLR)7刺激薬イミキモドの膀胱内注入は頻尿を誘発する
    市原 浩司, 相澤 直樹, 杉山 梨乃, 伊藤 悠城, 亀井 潤, 秋山 佳之, 舛森 直哉, 本間 之夫, 井川 靖彦 日本泌尿器科学会総会 103回 477 -477 2015年04月 [査読無し][通常論文]
  • 加齢に伴うラット排尿動態の変化と長期カロリー制限による予防効果 排尿行動測定(FV測定)および膀胱内圧測定(CMG)による検討
    亀井 潤, 伊藤 悠城, 相澤 直樹, 杉山 梨乃, 秋山 佳之, 市原 浩司, 藤田 泰典, 伊藤 雅史, 本間 之夫, 井川 靖彦 日本泌尿器科学会総会 103回 552 -552 2015年04月 [査読無し][通常論文]
  • 尿路閉塞を伴った急性腎盂腎炎 重症尿路感染症への対応を考える 閉塞性腎盂腎炎の重症化を予測する危険因子を探る
    亀井 潤, 中川 徹, 西松 寛明, 宮嵜 英世, 東 剛司, 藤村 哲也, 福原 浩, 久米 春喜, 井川 靖彦, 本間 之夫 日本化学療法学会雑誌 63 (2) 225 -225 2015年03月 [査読無し][通常論文]
  • 尿路閉塞を伴った急性腎盂腎炎 重症尿路感染症への対応を考える 閉塞性腎盂腎炎の重症化を予測する危険因子を探る
    亀井 潤, 中川 徹, 西松 寛明, 宮嵜 英世, 東 剛司, 藤村 哲也, 福原 浩, 久米 春喜, 井川 靖彦, 本間 之夫 感染症学雑誌 89 (2) 299 -300 2015年03月 [査読無し][通常論文]
  • 【90疾患の臨床推論!診断の決め手を各科専門医が教えます】 (第5章)腰背部痛 腎盂腎炎
    亀井 潤, 中川 徹, 本間 之夫 レジデントノート 16 (14) 2622 -2623 2014年12月 [査読無し][通常論文]
  • ラット膀胱の加齢性収縮能減弱とそれに対する長期カロリー制限による予防効果の背景因子の検討 脂質酸化ストレスおよび線維化の関与
    伊藤 悠城, 相澤 直樹, 杉山 梨乃, 亀井 潤, 秋山 佳之, 鈴木 基文, 市原 浩司, 小島 俊男, 藤田 泰典, 伊藤 雅史, 本間 之夫, 窪田 吉信, 井川 靖彦 日本排尿機能学会誌 25 (1) 149 -149 2014年09月 [査読無し][通常論文]
  • Transient receptor potential melastatin 2(TRPM2)チャネルの膀胱機能調節における生理的意義 ノックアウトマウスを用いた機能解析
    亀井 潤, 相澤 直樹, 中川 貴之, 伊藤 悠城, 杉山 梨乃, 秋山 佳之, 市原 浩司, 新美 文彩, 金子 周司, 藤村 哲也, 鈴木 基文, 福原 浩, 久米 春喜, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 25 (1) 150 -150 2014年09月 [査読無し][通常論文]
  • ラット膀胱伸展受容一次求心性神経のC線維の活動性に対する膀胱ムスカリン受容体の促進的寄与
    相澤 直樹, 伊藤 悠城, 杉山 梨乃, 亀井 潤, 秋山 佳之, 市原 浩司, 藤村 哲也, 鈴木 基文, 福原 浩, 久米 春喜, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 25 (1) 177 -177 2014年09月 [査読無し][通常論文]
  • ラット膀胱伸展受容求心性神経活動制御における膀胱アドレナリンα1D受容体の生理的役割
    相澤 直樹, 伊藤 悠城, 杉山 梨乃, 亀井 潤, 秋山 佳之, 市原 浩司, 藤村 哲也, 鈴木 基文, 福原 浩, 久米 春喜, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 25 (1) 177 -177 2014年09月 [査読無し][通常論文]
  • ハンナ型間質性膀胱炎と非ハンナ型間質性膀胱炎は別の病態か Tissue Studioを用いた病理組織の定量的解析
    秋山 佳之, 前田 大地, 山田 幸央, 新美 文彩, 野宮 明, 亀井 潤, 相澤 直樹, 鈴木 基文, 藤村 哲也, 中川 徹, 福原 浩, 久米 春喜, 井川 靖彦, 深山 正久, 本間 之夫 日本排尿機能学会誌 25 (1) 180 -180 2014年09月 [査読無し][通常論文]
  • 膀胱出口部閉塞後亜急性期の雄性ラットの尿流動態に対するTRPA1およびTRPV1チャネルの関与
    杉山 梨乃, 相澤 直樹, 伊藤 悠城, 亀井 潤, 秋山 佳之, 市原 浩司, 藤村 哲也, 鈴木 基文, 福原 浩, 久米 春喜, 本間 之夫, 井川 靖彦 日本排尿機能学会誌 25 (1) 199 -199 2014年09月 [査読無し][通常論文]
  • 難治性間質性膀胱炎に対するボツリヌス毒素膀胱壁内注入療法の効果予測因子の検討 当院における無作為化比較試験結果から
    秋山 佳之, 野宮 明, 新美 文彩, 山田 幸央, 亀井 潤, 鈴木 基文, 藤村 哲也, 中川 徹, 福原 浩, 久米 春喜, 井川 靖彦, 本間 之夫 日本排尿機能学会誌 25 (1) 212 -212 2014年09月 [査読無し][通常論文]
  • ハンナ病変凝固術の効果持続期間に影響を与える因子の検討
    新美 文彩, 山田 幸央, 野宮 明, 秋山 佳之, 亀井 潤, 藤村 哲也, 井川 靖彦, 本間 之夫 日本排尿機能学会誌 25 (1) 263 -263 2014年09月 [査読無し][通常論文]
  • 松本 明彦, 京野 陽子, 亀井 潤, 前川 滋克, 市川 寛樹, 福島 啓司, 横山 みなと, 古賀 文隆, 比島 恒和, 本間 之夫, 篠原 充 泌尿器外科 27 (臨増) 757 -757 2014年05月 [査読無し][通常論文]
  • 辻井 俊彦, 高沢 亮治, 北山 沙知, 篠原 充, 山田 幸央, 亀井 潤, 松本 明彦, 京野 陽子, 吉川 哲夫 泌尿器外科 27 (臨増) 769 -769 2014年05月 [査読無し][通常論文]
  • 難治性尿路結石の治療戦略 難治性尿路結石における腹腔鏡下手術の可能性
    西松 寛明, 新美 彩美, 宮嵜 英世, 村田 高史, 亀井 潤, 杉原 亨, 鈴木 基文, 藤村 哲也, 福原 浩, 中川 徹, 久米 春喜, 平野 美和, 本間 之夫 日本泌尿器科学会総会 102回 356 -356 2014年04月 [査読無し][通常論文]
  • ベータ3作動薬ミラベグロンの低コンプライアンス膀胱に対する有効性の検討
    亀井 潤, 古田 昭, 新美 文彩, 秋山 佳之, 吉田 美香子, 鈴木 基文, 藤村 哲也, 久米 春喜, 真田 弘美, 井川 靖彦, 本間 之夫 日本泌尿器科学会総会 102回 567 -567 2014年04月 [査読無し][通常論文]
  • 松本 明彦, 京野 陽子, 亀井 潤, 前川 滋克, 市川 寛樹, 堀口 慎一郎, 五嶋 孝博, 本間 之夫, 篠原 充 泌尿器外科 26 (10) 1589 -1592 2013年10月 [査読無し][通常論文]
     
    症例は45歳、男性。近医の超音波検査で偶然右水腎症を指摘され、当科を受診した。CTにて尿管周囲の軟部組織による尿管狭窄が疑われたため、腫瘍切除術および右尿管部分切除術を行った。病理診断にて腸間膜線維腫症を認め、その壁外性圧迫により尿管狭窄をきたしていた。術後水腎症は改善したが、腫瘍の切除断端が陽性であったため、再発予防目的にトラニラストの投与を行い、3年間再発なく経過している。(著者抄録)
  • ミラベグロンが低コンプライアンス膀胱の改善に有効であった神経因性下部尿路機能障害の2例
    亀井 潤, 井川 靖彦, 古田 昭, 吉田 美香子, 久米 春喜, 本間 之夫 日本排尿機能学会誌 24 (1) 275 -275 2013年09月 [査読無し][通常論文]
  • 辻井 俊彦, 高沢 亮治, 北山 沙知, 篠原 充, 山田 幸央, 亀井 潤, 京野 陽子, 吉川 哲夫, 有澤 千鶴, 飯村 康正, 河村 尚子, 山本 秀伸 泌尿器外科 26 (臨増) 725 -725 2013年05月 [査読無し][通常論文]
  • 多発性嚢胞腎に腎細胞癌が合併し、積極的治療を行う過程で維持透析導入に至った症例
    松本 明彦, 京野 陽子, 亀井 潤, 岩佐 悠子, 安藤 稔 日本透析医学会雑誌 46 (Suppl.1) 799 -799 2013年05月 [査読無し][通常論文]
  • 前立腺肥大症に対する5α還元酵素阻害薬デュタステリド単独投与の治療効果(第2報)
    辻井 俊彦, 高沢 亮治, 北山 沙知, 篠原 充, 松本 明彦, 亀井 潤, 京野 陽子, 吉川 哲夫, 有澤 千鶴, 飯村 康正, 河村 尚子 日本泌尿器科学会雑誌 104 (2) 329 -329 2013年03月 [査読無し][通常論文]
  • 治療前PSAが1000ng/m以上の転移性前立腺癌の予後
    市川 寛樹, 京野 陽子, 亀井 潤, 松本 明彦, 篠原 充 日本泌尿器科学会雑誌 104 (2) 477 -477 2013年03月 [査読無し][通常論文]
  • 京野 陽子, 前田 義治, 亀井 潤, 山田 幸央, 篠原 充 泌尿器外科 25 (11) 2193 -2196 2012年11月 [査読無し][通常論文]
     
    77歳男。2011年1月の健診にて右水腎症、腎機能障害(SCr:1.6mg/dl)を指摘された。尿細胞診positive(small cell carcinoma susp.)であり、画像所見で一部膀胱浸潤を伴う右下部尿管腫瘍と周囲リンパ節腫大が認められた。腫瘍マーカーはLDHのみ上昇を認めた。3月TUR-BT施行。組織学的にCD56(+)、synaptophisin(-)、Chromogranin(-)、NSE(-)より、WHO肺癌組織分類に準じてlarge cell neuroendocrine carcinomaと診断した。4月〜当院化学療法科入院しCPT-11+CBDCA併用療法開始した。短期的にはPRが得られていたが、総合効果はPD、加療開始6ヵ月後に癌死した。(著者抄録)
  • 亀井 潤, 小林 史岳, 赤羽 伸一, 佐藤 滋則, 太田 信隆 泌尿器外科 25 (9) 1915 -1915 2012年09月 [査読無し][通常論文]
  • 亀井 潤, 京野 陽子, 山田 幸央, 篠原 充, 本間 之夫 泌尿器科紀要 58 (7) 361 -364 2012年07月 [査読無し][通常論文]
     
    32歳男性。左精巣腫大を主訴に来院となり左高位精巣摘除術を施行、病理組織学的にはembryonal cell carcinoma with intratubular germ cell neoplasia(stage 1)のnon-seminomaであった。今回、経過観察から1年3ヵ月後、腫瘍マーカーの上昇ほか、CTにて傍大動脈リンパ節腫大が確認され、精巣腫瘍の再発が疑われた。また、あわせてCKの著明な上昇も認めて入院となった。腹部CTでは左傍大動脈リンパ節に腫大したリンパ節が多数認められ、アレルギー膠原病科にコンサルトしたところ、MRIおよび筋電図、筋生検で筋原性の炎症が疑われ、病理組織学的にも多発筋炎の筋組織像が確認された。以上より、本症例は精巣腫瘍に合併した多発性筋炎と診断され、まず精巣腫瘍の治療としてBEPの2コースが施行された。しかし、腫瘍マーカーの低下やリンパ節の縮小は認められたものの、CKは依然高値であり、加えて近位筋の萎縮進行、嚥下困難、構音障害、頭部支持困難等が出現したため、筋炎治療への方針へ一旦変更することとなった。そこで、アレルギー膠原病科にてγグロブリン大量療法(IVIG)が開始されたが、当夜に呼吸不全と誤嚥性肺炎を発症した。誤嚥性肺炎の改善をみてからIVIGが再開されたが、CKの高値は持続し、ステロイドパルス療法を行うことで低下が認められた。以後、精巣腫瘍に対してPE療法を1コース施行することとなり、その結果、腫瘍マーカーの正常化とリンパ節腫大の消失によりCRが得られた。尚、化学療法後7年経過現在、腫瘍ならびに筋炎の再発は認められていない。
  • 亀井 潤, 篠原 充, 本間 之夫 臨床泌尿器科 66 (7) 514 -516 2012年06月 [査読無し][通常論文]
  • 山田 幸央, 京野 陽子, 亀井 潤, 篠原 充, 本間 之夫 泌尿器外科 25 (臨増) 1090 -1090 2012年05月 [査読無し][通常論文]
  • 亀井 潤, 京野 陽子, 山田 幸央, 篠原 充, 本間 之夫 泌尿器外科 25 (臨増) 1103 -1103 2012年05月 [査読無し][通常論文]
  • 京野 陽子, 前田 義治, 山田 侑子, 船田 信顕, 亀井 潤, 山田 幸央, 篠原 充 泌尿器外科 25 (臨増) 1115 -1115 2012年05月 [査読無し][通常論文]
  • 臨床的に腎癌stageIと診断された症例の治療成績 腎摘除と腎部分切除、無治療経過観察の比較
    山田 幸央, 京野 陽子, 亀井 潤, 篠原 充, 本間 之夫 日本泌尿器科学会雑誌 103 (2) 265 -265 2012年03月 [査読無し][通常論文]
  • D2前立腺癌の予後因子についての臨床的検討
    市川 寛樹, 京野 陽子, 亀井 潤, 山田 幸央, 篠原 充 日本泌尿器科学会雑誌 103 (2) 276 -276 2012年03月 [査読無し][通常論文]
  • 去勢抵抗性前立腺癌に対するデキサメサゾン治療の副作用による耐糖能の悪化に対する検討
    亀井 潤, 鈴木 基文, 藤村 哲也, 福原 浩, 西松 寛明, 榎本 裕, 石川 晃, 久米 春喜, 井川 靖彦, 京野 陽子, 山田 幸央, 篠原 充, 本間 之夫 日本泌尿器科学会雑誌 103 (2) 297 -297 2012年03月 [査読無し][通常論文]
  • 亀井 潤, 久米 春喜, 鈴木 基文, 藤村 哲也, 福原 浩, 榎本 裕, 西松 寛明, 石川 晃, 井川 靖彦, 本間 之夫 日本泌尿器科学会雑誌 103 (1) 18 -21 2012年 [査読無し][通常論文]
     
    76歳男性。8年前に左鼠径部の無痛性腫大を主訴に当科受診。左高位精巣摘除術を施行し、精索悪性線維性組織球腫(MFH)と診断された。断端陽性のため追加切除および後腹膜リンパ節郭清を施行し断端陰性を得たので、追加治療は行わなかった。術後8年後に左鼠径部に有痛性の皮下腫瘤が出現し入院した。CTにてMFHの局所再発、肝・副腎転移を認めた。その後、局所再発巣、転移巣は急速な増大を認め、入院28日目に死亡した。剖検にて、MFHの再発、肺・肝・左副腎・椎体骨・リンパ節転移が確認された。MFHの再発・転移のほとんどは早期に出現する。8年後に再発・転移した本症例は、極めて稀であると考えられる。(著者抄録)
  • 無治療で7年間転移なく経過した両側腎細胞癌の1例
    亀井 潤, 小林 文岳, 赤羽 伸一, 佐藤 滋則, 太田 信隆, 久米 春喜, 本間 之夫 泌尿器外科 24 (9) 1541 -1544 2011年09月 [査読無し][通常論文]
     
    81歳女性。高血圧の精査中に偶然両側性腎腫瘍が発見され、Dynamic CT、MRIにて両側腎細胞癌(右:6.0cm、左7.0cm)と診断された。他臓器浸潤・転移を認めなかったが、積極的な治療を希望されず、無治療経過観察となった。その後7年間経過するも腫瘍の増大は認めるが(右:7.0cm、左:10.1cm)、明らかな他臓器浸潤・転移は認められていない。(著者抄録)
  • 当院での尿路上皮癌スクリーニングにおける尿中NMP-22測定の検討
    小林 史岳, 亀井 潤, 森本 裕彦, 赤羽 伸一, 佐藤 滋則, 太田 信隆 泌尿器外科 24 (臨増) 529 -529 2011年04月 [査読無し][通常論文]
  • 尿路性敗血症をきたした重症急性腎盂腎炎の検討
    亀井 潤, 西松 寛明, 鈴木 基文, 藤村 哲也, 福原 浩, 榎本 裕, 石川 晃, 久米 春喜, 井川 靖彦, 本間 之夫 日本泌尿器科学会雑誌 102 (2) 564 -564 2011年03月 [査読無し][通常論文]
  • 亀井 潤, 本間 之夫, 西松 寛明, 鈴木 基文, 藤村 哲也, 福原 浩, 榎本 裕, 石川 晃, 久米 晴喜, 井川 靖彦 日本泌尿器科学会雑誌 102 (2) 564 -564 2011年 [査読無し][通常論文]
  • 原発性アルドステロン症にプレクリニカルクッシング症候群を合併し、副腎部分切除術を施行した一例
    佐藤 滋則, 亀井 潤, 小林 史岳, 赤羽 伸一, 太田 信隆 日本内分泌外科学会総会プログラム・抄録集 22回 119 -119 2010年04月 [査読無し][通常論文]


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.