研究者総覧

丹波 嘉一郎 (タンバ カイチロウ)

  • 緩和ケア部 教授
Last Updated :2021/12/07

研究者情報

学位

  • 医学博士(自治医科大学)

ホームページURL

J-Global ID

プロフィール

  • 1984年自治医科大学卒。千葉県での義務年限後,1993年自治医科大学腎臓内科入局。1997年アラバマ大学バーミングハム校腎臓内科留学。2000年総合診療部講師。同大附属病院緩和ケア委員となる。2005年アルバータ大学地域緩和ケアプログラムにて3ヶ月緩和ケア研修医。2006年緩和ケア部助教授。2009年~附属病院緩和ケア部教授。2010年~2013年緩和医療講座(寄付講座)教授。

研究キーワード

  • 医学教育   予後予測   緩和ケア   詩歌療法   Palliative medicine   

研究分野

  • ライフサイエンス / 腎臓内科学
  • ライフサイエンス / 内科学一般 / 緩和ケア
  • ライフサイエンス / 医療管理学、医療系社会学

経歴

  • 2013年04月 - 現在  自治医科大学附属病院緩和ケア部教授
  • 2010年04月 - 2013年03月  緩和医療講座教授
  • 2009年 - 2010年03月  緩和ケア部教授
  • 2006年 - 2009年  緩和ケア部准教授
  • 自治医科大学(JMU)教授

所属学協会

  • 日本緩和医療学会   日本透析医学会   日本腎臓学会   日本内科学会   

研究活動情報

書籍

  • 治癒を望めない造血器腫瘍患者への医療と看護
    室井 一男, 丹波 嘉一郎 (担当:共編者(共編著者))
    医薬ジャーナル社 2012年09月
  • Dying, Bereavement and the Healing Arts
    TAMBA Kaichiro (担当:共著)
    Jessica Kingsley Publishers 2007年10月

MISC

  • The use of personalized poems in palliative care: one Japanese professional's experience
    International Journal of Palliative Nursing Vol. 10, p534-536 2004年 [査読無し][通常論文]
  • The use of personalized poems in palliative care: one Japanese health professional's experience
    International Journal of Palliative Nursing Vol. 10, p534-536 2004年 [査読無し][通常論文]
  • Kaichiro Tamba, Young Suk Oh, John Kevin Tucker, Michael William Quick, David Gene Warnock Clinical and Experimental Nephrology 6 (4) 195 -201 2002年12月 [査読無し][通常論文]
     
    Background. The regulation of the epithelial sodium channel (ENaC) is a key determinant of sodium homeostasis. The effect of cyclic AMP (cAMP) on ENaC activity is tissue-specific, and is controversial when ENaC is expressed in Xenopus oocytes. Methods. The modulation of ENaC by cAMP in oocytes expressing human or rat ENaC was performed with two-electrode voltage clamping. Results. 250μM 8-(4-chlorophenylthio)-adenosine 3′, 5′-cyclic monophosphate (8-CPT-cAMP) added to the bath significantly increased normalized amiloride-sensitive currents within 60s in oocytes expressing human α, β, and γ subunits (5ng cRNA each). The cAMP effect was dose-dependent and was partially inhibited by 200μM Rp-CPT-cAMP, a competitive cAMP antagonist. A transient effect of 8-CPT-cAMP on rat ENaC activity was also observed. Oocytes expressing rat α subunits with γ subunits (which have a putative protein kinase A phosphorylation site) showed similar increases in amiloride-sensitive current with 250μM 8-CPT-cAMP, while oocytes expressing rat α sub-units with β subunits were not activated by 8-CPT-cAMP. Further, rat ENaC (but not human ENaC)-expressing oocytes were not activated by cAMP when oocytes were continuously superfused during electrophysiological recordings, suggesting that rat ENaC activation by cAMP is dependent upon the condition of oocytes during cAMP stimulation. Conclusion. The present results suggest that ENaC expressed in Xenopus oocytes can be activated by cAMP, and that the γ subunit confers sensitivity to cAMP modulation of rat ENaC activity.
  • Kaichiro Tamba, Young Suk Oh, John Kevin Tucker, Michael William Quick, David Gene Warnock Clinical and Experimental Nephrology 6 (4) 195 -201 2002年12月 [査読無し][通常論文]
     
    Background. The regulation of the epithelial sodium channel (ENaC) is a key determinant of sodium homeostasis. The effect of cyclic AMP (cAMP) on ENaC activity is tissue-specific, and is controversial when ENaC is expressed in Xenopus oocytes. Methods. The modulation of ENaC by cAMP in oocytes expressing human or rat ENaC was performed with two-electrode voltage clamping. Results. 250μM 8-(4-chlorophenylthio)-adenosine 3′, 5′-cyclic monophosphate (8-CPT-cAMP) added to the bath significantly increased normalized amiloride-sensitive currents within 60s in oocytes expressing human α, β, and γ subunits (5ng cRNA each). The cAMP effect was dose-dependent and was partially inhibited by 200μM Rp-CPT-cAMP, a competitive cAMP antagonist. A transient effect of 8-CPT-cAMP on rat ENaC activity was also observed. Oocytes expressing rat α subunits with γ subunits (which have a putative protein kinase A phosphorylation site) showed similar increases in amiloride-sensitive current with 250μM 8-CPT-cAMP, while oocytes expressing rat α sub-units with β subunits were not activated by 8-CPT-cAMP. Further, rat ENaC (but not human ENaC)-expressing oocytes were not activated by cAMP when oocytes were continuously superfused during electrophysiological recordings, suggesting that rat ENaC activation by cAMP is dependent upon the condition of oocytes during cAMP stimulation. Conclusion. The present results suggest that ENaC expressed in Xenopus oocytes can be activated by cAMP, and that the γ subunit confers sensitivity to cAMP modulation of rat ENaC activity.
  • 日本腎臓学会誌 Vol43. P646-P650 2001年 [査読無し][通常論文]
  • Cloning and functional studies of splice variants of the alpha-subunit of the amiloride-sensitive Na+ channel.(共著)
    Am J Physiol 274 C1081 1998年 [査読無し][通常論文]
  • Transcriptional activation of RACTK1 K+ channel gene by apical activation in renal cortical collecting duct(共著)
    J Clin Inverst 98 (2) 474 1996年 [査読無し][通常論文]
  • HTLV-1 associated myelopathy in a patient with chronic renal failure
    Nephron 66 (3) 351 1994年 [査読無し][通常論文]

共同研究・競争的資金等の研究課題

  • 一般医と腎専門医の慢性腎不全への対応の相違
  • 緩和ケアと詩歌療法
  • 院内独自の緩和ケアマニュアルの作成とその効果
  • シスタチンCの腎機能評価における位置づけ
  • Differences in decision-making in treatment of renal insufficiency between physicians and nephrologists.
  • Palliative medicine and poetry therapy
  • Palliative care support system with mailing-list.
  • Cystatin-C as a marker of glomerular filtration ratio


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