研究者総覧

野田 弘志 (ノダ ヒロシ)

  • 総合医学第2講座 准教授
メールアドレス: noda164omiya.jichi.ac.jp
Last Updated :2020/07/29

研究者情報

学位

  • 医学博士

学位

    野田 弘志

ホームページURL

科研費研究者番号

  • 00382937

J-Global ID

研究キーワード

  • 消化器外科   肝胆膵外科   Hepato-Biriary-Pancreatic Surgery   

研究分野

  • ライフサイエンス / 消化器外科学

経歴

  • 2014年05月 - 現在  自治医科大学附属さいたま医療センター一般・消化器外科准教授
  • 2008年04月 - 2014年04月  自治医科大学附属さいたま医療センター一般・消化器外科講師
  • 2005年04月 - 2007年11月  自治医科大学附属さいたま医療センター一般・消化器外科助手

学歴

  • 2001年04月 - 2005年03月   自治医科大学大学院
  •         - 1992年03月   自治医科大学(JMU)   医学部   医学科
  •         - 1992年   自治医科大学   Faculty of Medicine

所属学協会

  • 日本胆道学会   日本膵臓学会   日本内視鏡外科学会   日本肝臓学会   日本臨床外科学会   日本肝胆膵外科学会   日本消化器外科学会   日本外科学会   

研究活動情報

論文

  • Motohiro Tsuboi, Hiroshi Noda, Fumiaki Watanabe, Iku Abe, Mitsuhiro Nokubi, Toshiki Rikiyama
    INTERNATIONAL SURGERY 100 3 574 - 578 2015年03月 [査読有り][通常論文]
     
    We herein describe the case of an adult with a complicated huge lymphangioma of the small bowel mesentery. Computed tomography (CT) confirmed a 45X30X14 cm multiple and separate, mixed and solid cystic tumor without enhancement by contrast medium in the abdominal cavity. Mesenteric CT angiography with three-dimensional (3D) reconstruction showed that the tumor did not involve the first jejunal artery, although the tumor did involve the subsequent jejunal and ileal arteries and the corresponding segment of the small bowel. Under anatomic guidance based on mesenteric CT angiography with 3D reconstruction, we were able to successfully excise the tumor. Mesenteric lymphangioma should be excised even when the tumor is asymptomatic. Mesenteric CT angiography with 3D reconstruction is useful for the surgical treatment of huge mesenteric tumors.
  • Takaharu Kato, Koichi Suzuki, Yuta Muto, Junichi Sasaki, Shingo Tsujinaka, Yutaka J. Kawamura, Hiroshi Noda, Hisanaga Horie, Fumio Konishi, Toshiki Rikiyama
    WORLD JOURNAL OF SURGICAL ONCOLOGY 13 1 23  2015年02月 [査読有り][通常論文]
     
    Background: Improvement in the prognosis of colorectal cancer (CRC) patients has led to increasing occurrences of multiple primary malignancies (MPMs) alongside CRC but little is known about their characteristics. This study was undertaken to clarify the clinical and pathological features of MPMs, especially those at extra colonic sites, in patients with CRC. Methods: We reviewed 1,111 patients who underwent operations for primary sporadic CRC in Saitama Medical Center, Jichi Medical University between April 2007 and March 2012. Two patients with familial adenomatous polyposis, one with hereditary non-polyposis colorectal cancer, two with colitic cancer, and any patients with metastasis from CRC were excluded. We compared the clinicopathological features of CRC patients with and without MPMs. As a control, we used a database compiled of patients with gastric cancer (GC) detected by mass screening performed in the Saitama Prefecture in Japan 2010 and compared these with CRC patients with synchronous GC. Results: Multiple primary malignancies at extracolonic sites were identified in 117 of 1,111 CRC patients (10.5%). The median age was 68 (range, 29 to 96) versus 71 (50 to 92) (P < 0.001). The incidence of GC (44.4% (52 of 117)) was the highest of all MPMs. All CRC patients with GC were older than 57 years. Synchronous GC was detected in 26 patients. By contrast, out of 200,007 screened people, 225 people were diagnosed as having GC in the Saitama Prefecture. The age-standardized incidence of synchronous GC in CRC patients was significantly higher (0.53%) than in the control group (0.03%) (odds ratio, 18.8; 95% confidence interval, 18.6 to 19.0; P < 0.001). Conclusion: Patients with CRC who were older than 50 years preferentially developed GC synchronously and metachronously. Thus, this patient group should undergo careful perioperative screening for GC.
  • Fumiaki Watanabe, Hiroshi Noda, Hidenori Kamiyama, Takaharu Kato, Nao Kakizawa, Kosuke Ichida, Nobuyuki Toyama, Fumio Konishi
    HEPATO-GASTROENTEROLOGY 59 116 1270 - 1273 2012年06月 [査読有り][通常論文]
     
    Background/Aims: Intra-abdominal infection (IAI) after pancreaticoduodenectomy (PD) is a common cause of prolongation of postoperative hospital stay and readmission to the hospital following discharge. Methodology: Two hundred and six patients undergoing PD were reviewed to investigate the risk factors for IAI after PD. Patients were separated into two groups: those who developed IAI after PD (Group A; n=44), and those who had not developed IAI after PD (Group B; n=162), the two groups were then compared to identify the risk factors for IAI after PD. A hundred and six patients (51.5%) underwent preoperative biliary drainage (PBD). Results: Multivariate analysis revealed that pancreatic fistula (PF) was an independent risk factor for IAI after PD (p<0.001; odds ratio=9.58; 95% confidence interval=4.37-21.0), but PBD was not a significant risk factor. Conclusions: We demonstrated that the adequate PBD might not affect IAI after PD. On the other hand, PF was an independent risk factor for IAI after PD. A large randomized controlled trial, which would prove the effect of early removal of a prophylactic placed drain to prevent IAI, should be planned.
  • Noda H, Suminaga Y, Kato T, Kamiyama H, Konishi F
    Asian J Endosc Surg 4 16 - 19 2011年 [査読有り][通常論文]
  • Noda H, Kato T, Kamiyama H, Toyama N, Konishi F
    Clin J Gastroenterol 4 24 - 27 2011年 [査読有り][通常論文]
  • MIZUTA Noritoshi, NODA Hiroshi, KAKIZAWA Nao, TOYAMA Nobuyuki, KONISHI Fumio
    自治医科大学紀要 32 111 - 118 2010年03月 [査読無し][通常論文]
  • Noda H, Kato T, Kamiyama H, Toyama N, Konishi F
    Clin J Gastroenterol. 3 259 - 261 2010年 [査読有り][通常論文]
  • Hiroshi Noda, Fumihiro Chiba, Nobuyuki Toyama, Fumio Konishi
    JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY 16 1 83 - 85 2009年01月 [査読有り][通常論文]
     
    Mucin-producing carcinoma of the gallbladder is very rare. We report here a case of mucin-producing carcinoma of the gallbladder associated with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). A 74-year-old female had been treated with salazosulfapyridine and ursodesoxycholic acid becase of UC and PSC. After 7 years of treatment, laboratory data showed that the liver function took a turn for the worse, and the patient was admitted to our hospital for further examination. Enhanced computed tomography and ultrasonography showed an enlarged gallbladder associated with wall thickening and diffuse papillary protrusion. Endoscopic retrograde cholangiography showed stenosis and dilatation of the bile duct, which were compatible with PSC. Under the diagnosis of an early carcinoma of the gallbladder, we performed simple cholecystectomy. The tumor showed a papillary growth pattern located diffusely in the gallbladder with a massive amount of mucin filling the gallbladder. Histologically, it was diagnosed as a papillary adenocarcinoma localized in the mucosal layer. To the best of our knowledge, this is the first case of mucin-producing carcinoma of the gallbladder associated with PSC and UC. PSC and UC patients should be regarded as a high-risk group not only for cholangiocarcinoma but also carcinoma of the gallbladder.
  • Promoter hypermethylation of tumor-related genes in sporadic colorectal cancer in young patients
    H. Noda, R. Mashima, H. Kamiyama, S. Okada, Y. J. Kawamura, F. Konishi
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 26 4 521 - 526 2007年12月 [査読有り][通常論文]
     
    Sporadic colorectal cancer (SCRC) occurring in young patients represent a subset with a higher proportion of advanced tumors and a poor prognosis, however, the genetic basis of SCRCs has not yet been sufficiently studied. We assigned 16 SCRC patients aged 40 years or less to group 1, and 30 SCRCs patients aged 65 years or more to group 2. The methylation status in the promoter of 7 tumor suppressor genes regarding these two groups was then examined. The average number of hypermethylated tumor-related genes per sample in group 1 was 1.50 +/- 0.07, which was significantly lower than that in group 2 of 2.73 +/- 1.24 (p=0.0040). The frequencies of the promoter hypermethylation of hMLH1, p15INK4b, p16INK4a, and RASSF1A in group 1 were 12.5%, 12.5%, 12.5%, 6.3%, and 0.0%, which were substantially less frequent than those same rates observed in group 2. In contrast, the frequencies of the promoter hypermethylation of APC, MGMT, p14ARF, in group 1 were 43.8%, 37.5%, and 31.3%, which were as frequent as those seen in group 2. The promoter hypermethylation of APC, MGMT, and p14ARF is therefore considered to be closely related to the development of SCRCs in young patients, regardless of aging.
  • CHIBA Fumihiro, TOYAMA Nobuyuki, NODA Hiroshi, KONISHI Fumio
    自治医科大学紀要 30 139 - 145 2007年12月 [査読無し][通常論文]
  • H. Noda, Y. Miyaji, A. Nakanishi, F. Konishi, Y. Miki
    BRITISH JOURNAL OF CANCER 96 2 383 - 390 2007年01月 [査読有り][通常論文]
     
    Recent studies have suggested that epigenetic inactivation of tumour-related genes by promoter methylation participates in the development of gastric cancer. We newly identified the frequently aberrant promoter methylation of alpha-1B-adrenergic receptor (ADRA1B) in colorectal cancer by methylation-sensitive representational difference analysis (MS-RDA) and examined the methylation status of the ADRA1B promoter in 34 paired samples of colorectal cancer and surrounding epithelial tissue, and 34 paired samples of gastric cancer and surrounding epithelial tissue. In colorectal cancers, only four of 34 (11.8%) tumours showed ADRA1B promoter methylation. In contrast, ADRA1B promoter methylation was detected in 24 of 34 (70.6%) gastric cancers and in 14 of 34 (41.2%) surrounding epithelial tissues. The frequency of ADRA1B promoter methylation was higher in gastric epithelial tissues with intestinal metaplasia (41.6%) than in those without intestinal metaplasia (25.0%). Reverse transcription-PCR detected reduced ADRA1B expression in 12 of 18 (66.7%) gastric cancers, and its promoter methylation was detected in 11 of these 12 (91.7%) gastric cancers with reduced ADRA1B expression. Thus, ADRA1B promoter is frequently methylated in gastric cancer. Our results suggest that the ADRA1B gene is an important tumour-related gene frequently involved in the development and progression of gastric cancer.
  • Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
    Noda H, Kato Y, Yoshikawa H, Arai M, Togashi K, Nagai H, Konishi F, Miki Y
    J Exp Clin Cancer Res 69 235 - 242 2006年 [査読有り][通常論文]
  • IIJIMA Yuki, NODA Hiroshi, SUMINAGA Yoshihisa, HYODO Takashi, YAMADA Shigeki, KONISHI Fumio
    自治医科大学医学部紀要 28 117 - 123 2005年12月 [査読無し][通常論文]
  • Natural history of a patient with malignant nonfunctioning islet cell tumor associated with unresectable multiple liver metastases
    H Noda, N Toyama, Y Suminaga, F Konishi
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 23 2 349 - 351 2004年06月 [査読有り][通常論文]
     
    Islet cell tumors of the pancreas are uncommon. Approximately 15% of islet cell tumors are nonfunctioning and have a higher malignancy rate than their functioning counterparts. Though, because of the rarity of malignant nonfunctioning islet cell tumors, the natural history of a patient with this tumor has not been clearly defined. We describe a young patient with unresectable malignant nonfunctioning islet cell tumor associated with multiple liver metastases. He was treated with palliative therapies to improve his quality of life, but did not undergo surgical removal of tumors or systemic chemotherapy. He survived for 46 months since laparotomy for histological diagnosis. Our findings may represent the natural history of patients with unresectable malignant nonfunctioning islet cell tumor, and suggest that palliative therapy may contribute not only to the improvement of a patients' quality of life but also the prolongation of survival.
  • H Noda, Y Maehara, K Irie, Y Kakeji, T Yonemura, K Sugimachi
    CANCER 92 7 1828 - 1835 2001年10月 [査読有り][通常論文]
     
    BACKGROUND. The growth pattern of early gastric carcinoma, as based on a volumetric analysis, reflects the biologic characteristics of a tumor. The penetrating growth (Pen) type tumor has an unfavorable prognosis, compared with the case of a superficially spreading (Super) type. The wild-type of the p53 protein plays an important role in cell growth regulation and apoptosis. The p21 protein, which is encoded by the WAF1/CIP1 gene, is a downstream target effector of wild-type p53 protein, and these proteins act as tumor suppressors in a negative cell-cycle regulation. METHODS. In 133 Japanese patients with early gastric carcinoma with submucosal invasion, expressions of p53 and p21 proteins were studied immunohistochemically, and the relation between growth pattern and expressions was analyzed. RESULTS. Early gastric carcinomas were grouped into the superficially spreading (Super) type 40 (30.1%) cases, expansively penetrating growth (Pen-A) type 28 (21.1%), infiltratively penetrating growth (Pen-B) type 20 (15.0%), small mucosal type 35 (26.3%), and mixed type 10 (7.5%). The Pen-A type tumors were characterized by the highest incidence of p53 expression and loss of p21 expression, and the rate of p53-positive and/or p21-negative cases was 71.4%. There were significant differences in the incidence of the p53 expression (50.0% vs. 25.0%), the loss of p21 expression (53.6% vs. 27.5%), and the 5-year survival rate (83.2% vs. 97.2%) between the Pen-A type and the Super type. CONCLUSIONS. Thus, deregulation of the cell cycle by p53 and p21 in this study was shown to play an important role in progression of Pen-A type early gastric carcinoma. (C) 2001 American Cancer Society.

MISC

  • Increased Proliferative Activity caused by loss of P21 WAF1/CIP1 Expression and its Clinical Significance in Patients with Early-Stage Gastric Carcinoma
    Cancer 94(7), 2107-2112 2002年 [査読無し][通常論文]
  • Effectiveness of Preoperative Chemotherapy for Far Advanced Gastric Cancer
    Hepatogastroenterology 49 (44) 379 -382 [査読無し][通常論文]

共同研究・競争的資金等の研究課題

  • 肝胆膵外科、消化器外科
  • Hepato-Biriary-Pancreatic Surgery, Carcinogenesis

委員歴

  • 日本臨床外科学会   評議員   日本臨床外科学会
  • 日本肝胆膵外科学会   評議員   日本肝胆膵外科学会


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