研究者総覧

木原 淳 (キハラ アツシ)

  • 病理学講座(統合病理学部門) 講師
Last Updated :2021/09/22

研究者情報

ホームページURL

科研費研究者番号

  • 10806756

ORCID ID

J-Global ID

研究キーワード

  • Human Pathology   Diagnostic Pathology   Gynecological Pathology   Immunohistochemistry   

研究分野

  • ライフサイエンス / 人体病理学

経歴

  • 2017年04月 - 現在  自治医科大学医学部 病理学講座 統合病理学部門

所属学協会

  • 国際病理アカデミー日本支部   日本臨床細胞学会   日本癌学会   日本病理学会   

研究活動情報

論文

講演・口頭発表等

  • 子宮間葉系腫瘍におけるSMARCA4とSMARCB1の発現の検討  [通常講演]
    第110回日本病理学会総会 2021年04月 ポスター発表
  • Immunohistochemical analysis of SWI/SNF complex subunits expression in endometrial carcinomas
    第109回日本病理学会総会(Web) 2020年07月
  • Atypical polypoid adenomyomaの間質成分の免疫組織化学的検討  [通常講演]
    Kihara Atsushi
    第108回日本病理学会総会 2019年05月 ポスター発表
  • High-grade endometrial carcinomaにおけるSNAILとSLUGの発現の検討  [通常講演]
    第105回日本病理学会総会 2016年05月 ポスター発表
  • 肝臓に発生したcystic changeを伴うグロムス腫瘍の1例  [通常講演]
    第101回日本病理学会総会 2012年04月 ポスター発表
  • 初発時の胸水に多数の腫瘍細胞を認めた形質細胞性白血病の1例  [通常講演]
    第52回日本臨床細胞学会総会(春期大会) 2011年05月 ポスター発表 福岡
  • 肺高分化胎児型腺癌の1例  [通常講演]
    第49回日本臨床細胞学会秋期大会 2010年11月 ポスター発表
  • 再発性多発軟骨炎に対するステロイド・免疫抑制剤投与中にHSVによる劇症肝炎と全身感染を発症した1剖検例  [通常講演]
    第99回日本病理学会総会 2010年04月 ポスター発表
  • 肺結節病変に対するDynamic MRIによる良悪性の鑑別能  [通常講演]
    第49回日本呼吸器学会学術講演会 2009年06月 ポスター発表
  • カルバマゼピンで重篤な好酸球性肺炎と紅皮症を呈した1例  [通常講演]
    日本内科学会関東地方会 2008年06月 口頭発表(一般)
  • 上行大動脈置換術後の経過観察中に弓部大動脈瘤が認められ、症状発症から約2日後に診断されたaorto-pulmonary fistulaの一例  [通常講演]
    日本救急医学会中部地方会 2006年11月 口頭発表(一般)

MISC

  • Ryoichi Miyamoto, Katsumi Amikura, Shinichi Matsudaira, Hiroyuki Ishida, Toshiro Ogura, Amane Takahashi, Atsushi Kihara, Hiroaki Kanda, Yoshiyuki Kawashima Surgical Case Reports 7 (1) 2021年12月
  • Yuichi Aoki, Hideki Sasanuma, Yuki Kimura, Akira Saito, Kazue Morishima, Yuji Kaneda, Kazuhiro Endo, Atsushi Yoshida, Atsushi Kihara, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Alan Kawarai Lefor, Naohiro Sata The Journal of international medical research 48 (10) 300060520962967 -300060520962967 2020年10月 [査読有り]
  • Yoshiyuki Inoue, Hisanaga Horie, Yuko Homma, Ai Sadatomo, Makiko Tahara, Koji Koinuma, Hironori Yamaguchi, Toshiki Mimura, Atsushi Kihara, Alan Kawarai Lefor, Naohiro Sata Surgical case reports 6 (1) 174 -174 2020年07月 [査読有り][通常論文]
  • Daisuke Matsubara, Taichiro Yoshimoto, Manabu Soda, Yusuke Amano, Atsushi Kihara, Toko Funaki, Takeshi Ito, Yuji Sakuma, Tomoki Shibano, Shunsuke Endo, Koichi Hagiwara, Shumpei Ishikawa, Masashi Fukayama, Yoshinori Murakami, Hiroyuki Mano, Toshiro Niki Cancer science 111 (6) 2183 -2195 2020年06月 [査読有り][通常論文]
  • Katsushi Suenaga, Shiro Matsumoto, Alan Kawarai Lefor, Yoshimasa Miura, Yoshinori Hosoya, Daigo Kuboki, Hidenori Haruta, Kentaro Kurashina, Atsushi Kihara, Daisuke Matsubara, Yasunari Sakuma, Joji Kitayama, Naohiro Sata International journal of surgery case reports 73 319 -323 2020年 [査読有り][通常論文]
  • Taichiro Yoshimoto, Daisuke Matsubara, Manabu Soda, Toshihide Ueno, Yusuke Amano, Atsushi Kihara, Takashi Sakatani, Tomoyuki Nakano, Tomoki Shibano, Shunsuke Endo, Koichi Hagiwara, Masashi Fukayama, Kaori Denda-Nagai, Tatsuro Irimura, Hiroyuki Mano, Toshiro Niki Cancer science 110 (9) 3006 -3011 2019年09月 [査読有り][通常論文]
     
    Decreased cell adhesion has been reported as a significant negative prognostic factor of lung cancer. However, the molecular mechanisms responsible for the cell incohesiveness in lung cancer have not yet been elucidated in detail. We herein describe a rare histological variant of lung adenocarcinoma consisting almost entirely of individual cancer cells spreading in alveolar spaces in an incohesive pattern. A whole exome analysis of this case showed no genomic abnormalities in CDH1 or other genes encoding cell adhesion molecules. However, whole mRNA sequencing revealed that this case had an extremely high expression level of mucin 21 (MUC21), a mucin molecule that was previously shown to inhibit cell-cell and cell-matrix adhesion. The strong membranous expression of MUC21 was found on cancer cells using mAbs recognizing different O-glycosylated forms of MUC21. An immunohistochemical analysis of an unselected series of lung adenocarcinoma confirmed that the strong membranous expression of MUC21 correlated with incohesiveness. Thus, MUC21 could be a promising biomarker with potential diagnostic and therapeutic applications for lung adenocarcinoma showing cell incohesiveness.
  • 倉重 理絵, 坂下 博之, 東 盛志, 内堀 健, 木原 淳, 稲瀬 直彦 肺癌 56 (4) 308 -313 2016年08月 [査読有り][通常論文]
     
    Background. Two ALK inhibitors are available for the treatment of lung cancer in Japan, but resistance to both is not uncommon. Case. A 37-year-old female was diagnosed with ALK-rearrangement-positive lung adenocarcinoma at cT2aN3M0, stage IIIB. She was initially treated with alectinib and showed a sustained partial response (PR) for four and a half months. She was then switched from alectinib to cisplatin and pemetrexed due to progressive disease (PD). On the 16th day of the second drug regimen she developed fever, elevated C-reactive protein levels, and rapidly enlarged lymph nodes. Re-treatment with alectinib attenuated her liver metastasis and partially reduced her lymph node enlargement, but several other lymph nodes continued to grow. The alectinib was then switched to crizotinib, which elicited a PR. A re-biopsied sample of the right supraclavicular lymph node tested positive for ALK-rearrangement by immunohistochemistry and fluorescence in situ hybridization analyses and included some MET-positive cells. We diagnosed adenocarcinoma based on the histological findings which were very similar to the findings we observed in the first examination. Conclusion. The patient's disease responded with a flare-like reaction after the alectinib was discontinued. The MET amplification observed after the alectinib was re-administered might have been related to a resistance mechanism in the growing tumor. Further research on ALK inhibitor resistance is therefore warranted.
  • Takaaki Mase, Atsushi Kihara, Kenshiro Arao European heart journal 36 (44) 3048 -3048 2015年11月 [査読有り][通常論文]
  • 両側副腎のprimary pigmented nodular adrenocortical diseaseからCarney complexの診断に到った2例
    土井 紀輝, 橋本 浩次, 郡司 真理子, 木原 淳, 福島 純一, 堀内 啓 診断病理 31 (1) 47 -51 2014年01月 [査読有り][通常論文]
  • Shiro Satoh, Shuichiro Nakaminato, Atsushi Kihara, Susumu Isogai, Shigeo Kawai Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 12 (1) 31 -8 2013年03月 [査読有り][通常論文]
     
    PURPOSE: We prospectively assessed whether enhancement characteristics on dynamic magnetic resonance (MR) imaging could distinguish indeterminate pulmonary nodules. METHODS: We evaluated 51 pulmonary nodules in 51 consecutive patients (11 female, 40 male; mean age, 64 years) using dynamic MR images acquired at 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 120, 150, 180, 210, 240, 360, 480, 600, 720, and 840 s following injection of contrast material. We prospectively evaluated morphologic enhancement patterns, peak rate, time to peak enhancement, steepest slope, and washout of nodules and analyzed statistics to determine any differences between MR parameters, patient age, tumor size, and final diagnosis. RESULTS: We found 25 malignant, 12 active inflammatory, and 14 benign nodules. Nodule diameter was significantly larger for malignant than nonmalignant, and benign nodules (P≤0.01). Patients with malignant nodules were significantly older than those with nonmalignant (P=0.01) and active inflammatory (P=0.02) nodules. However, morphologic enhancement patterns, peak rate, time to peak enhancement, steepest slope, and washout characteristics at 2, 4, 8, and 12 min showed no significant difference between malignant and nonmalignant nodules and among malignant, active inflammatory, and benign nodules. CONCLUSION: Prospective assessment of dynamic MR images demonstrated their inadequacy for distinguishing indeterminate pulmonary nodules.
  • Kenya Kobayashi, Kazunari Nakao, Sadahiro Kishishita, Noriko Tamaruya, Hiroko Monobe, Ken'ichi Saito, Atsushi Kihara Auris, nasus, larynx 40 (1) 89 -92 2013年02月 [査読有り][通常論文]
     
    OBJECTIVE: Vascular malformations may appear anywhere in the body; 14-65% are in the head and neck. There are several treatments (sclerotherapy, surgery, laser treatment, and embolization, etc.), but standardized guidelines for these treatments are lacking. We conducted a retrospective review of venous or capillary malformations of the head and neck, and analyzed the epidemiology, pathology and treatment. METHODS: We retrospectively reviewed 67 patients with pathologically diagnosed venous or capillary malformations of the head and neck; we analyzed the location, pathology and treatment, as well as recurrent/residual cases. RESULTS: The oral cavity (59%) and nasal cavity (35%) were the most common locations. The frequency of each pathological type depended upon location. Surgery was undertaken in 65 cases, and sclerotherapy done in one patient. Sixty-one cases (92%) had resectable lesions. However polycystic masses (≥3 cysts) and large masses (diameter, ≥5cm) were significantly difficult to cure by single treatment. CONCLUSIONS: Surgery is indicated for localized small vascular malformations. However if the lesions ≥5cm or polycystic lesions were more likely to recur after surgery alone in our study population.
  • Tetsuro Sameshima, Keita Shibahashi, Toshiki Nozaki, Atsuya Akabane, Atsushi Kihara, Hajime Horiuchi, Akio Morita Neurologia medico-chirurgica 53 (2) 125 -8 2013年 [査読有り][通常論文]
     
    A 69-year-old man presented with progressive paralysis of the right arm and leg with a past history of metastatic rectal cancer. Magnetic resonance imaging showed a cystic mass lesion posterior to the odontoid process. Under a preoperative diagnosis of intradural extramedullary tumor, partial transcondylectomy and C1 hemilaminectomy were performed, and the cyst was removed through a transdural approach, decompressing the medulla oblongata and the cervical spinal cord. The histological diagnosis was juxtafacet cyst (ganglion cyst). An atlantoaxial intraspinal juxtafacet cyst at the level of the odontoid process is extremely rare. In our case, the cyst was removed using a posterior approach, resulting in rapid improvement in symptoms.
  • Takahiko Nakajima, Nobuyuki Matsuhashi, Satoshi Nara, Atsushi Nakajima, Johji Imura, Atsushi Kihara, Kenichiro Murata, Junichi Fukushima, Hajime Horiuchi Pathology international 62 (8) 554 -8 2012年08月 [査読有り][通常論文]
     
    We report an adult case of midgut volvulus in familial visceral myopathy (FVM) that had affected family members over three generations. The patient was a Japanese woman in her fifties, who had chronic intestinal pseudo-obstruction (CIPO) since the age of about 40 years and had been treated chronically with conservative therapies. Her abdominal symptoms suddenly worsened and surgery became necessary. Surgery revealed a midgut volvulus secondary to intestinal malrotation and the twisted intestine was resected. Histology revealed diffuse damage of myocytes confined to the muscularis propria throughout the resected intestine. The myocytes were irregulary arranged, contained cytoplasmic inclusions, and had mild and focal vacuolar changes. The mucsularis propria showed hypertrophy with delicate interstitial fibrosis. A diagnosis of FVM was made on the basis of this characteristic myopathy. Intestinal malrotation is known to be a complication of CIPO in children, but is rare in adults. Although midgut volvulus appears to be extremely rare, it can occur after a relatively stable chronic phase in adult CIPO patients, who should be monitored carefully to assess the risk of such complications.
  • 分類不能の卵巣癌の一例
    飯原 久仁子, 木原 淳, 堀内 啓 日本婦人科病理学会誌 3 (1) 25 -27 2012年06月 [査読無し][通常論文]
  • Takahiko Nakajima, Tomonori Ushijima, Atsushi Kihara, Kenichiro Murata, Toshiro Sugiyama, Koichi Tsuneyama, Johji Imura, Junichi Fukushima, Hajime Horiuchi Case reports in gastrointestinal medicine 2012 606832 -606832 2012年 [査読有り][通常論文]
     
    We report a case of a gastrointestinal stromal tumor (GIST) of the stomach that demonstrated a stepwise progression from low- to high-grade malignancy. The patient had been followed for a small gastric submucosal tumor that had turned malignant after 8 years of indolence, manifested by tarry stools. The tumor was enucleated, and gastric GIST was diagnosed. The most significant histological finding was that the tumor comprised two clearly demarcated areas, one with less aggressive characteristics and the other with highly aggressive characteristics. The patient exhibited multiple liver metastases 24 months after surgery. Imatinib mesylate was not administered throughout the clinical course because it was not available for clinical use at that time. The patient followed an unfavorable clinical course and died of liver dysfunction 55 months after surgery. Autopsy was performed. By comparing the immunohistochemical profiles of primary and metastatic tumors, it was established that only the tumor cells with highly aggressive characteristics had metastasized.
  • 【GIST 診断・治療の進歩】GISTのリスク分類
    中嶋 隆彦, 木原 淳, 田島 将吾, 村田 建一郎, 松谷 章司, 堀内 啓, 杉山 敏郎 臨床消化器内科 25 (6) 663 -668 2010年05月 
    従来gastrointestinal stromal tumor(GIST)においては,腫瘍径と核分裂数を指標とする悪性度分類が広く世界的に用いられてきた.近年,術後補助療法としてのイマチニブの有効性が明らかとされたが,その対象の決定には再発率を含めた正確な悪性度評価(分類)が必要とされる.腫瘍径と核分裂数に加え発生部位を考慮した新しい悪性度分類では,腫瘍径と核分裂数が同等であっても胃以外の原発例では悪性度が高いことが明記された.新たな悪性度分類についてのわが国の成績は不十分で,今後の重要な課題である.(著者抄録)

受賞

  • 2020年11月 自治医科大学 優秀論文賞
     Stromal p16 expression helps distinguish atypical polypoid adenomyoma from myoinvasive endometrioid carcinoma of the uterus
  • 2018年 国際病理アカデミー日本支部 病理診断学術奨励賞
     Clinicopathologic association and prognostic value of microcystic, elongated, and fragmented (MELF) pattern in endometrial endometrioid carcinoma


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