研究者総覧

川人 宏次 (カワヒト コウジ)

  • 外科学講座(心臓血管外科学部門) 教授
Last Updated :2021/11/23

研究者情報

学位

  • 博士(医学)

ホームページURL

J-Global ID

研究キーワード

  • PCPS   体外循環   リンパ球   アポトーシス   心臓手術   

研究分野

  • ライフサイエンス / 心臓血管外科学
  • ライフサイエンス / 呼吸器外科学
  • ライフサイエンス / 心臓血管外科学

経歴

  • 2014年  自治医科大学医学部教授

学歴

  •         - 1986年   徳島大学   医学部   医学科
  •         - 1986年   徳島大学   Faculty of Medicine

所属学協会

  • The International Society for Rotary Blood Pumps   日本人工臓器学会   日本心臓血管外科学会   日本胸部外科学会   日本外科学会   

研究活動情報

MISC

  • 木村 直行, 伊藤 智, 田中 正史, 川人 宏次, 田村 敦, 木村 知恵里, 森田 英幹, 由利 康一, 松本 晴信, 安達 晃一, 山口 敦司, 安達 秀雄 日本外科学会雑誌 114 (2) 2013年03月 [査読無し][通常論文]
  • 齊藤 力, 三澤 吉雄, 河田 政明, 小西 宏明, 川人 宏次, 大木 伸一, 上西 祐一朗, 坂野 康人, 相澤 啓, 村岡 新, 佐藤 弘隆, 高澤 一平, 棚澤 壮樹, 宮原 義典 日本外科学会雑誌 114 (2) 2013年03月 [査読無し][通常論文]
  • 木村 直行, 田中 正史, 安達 秀雄, 川人 宏次, 山口 敦司, 井野 隆史 日本外科学会雑誌 109 (2) 2008年04月 [査読無し][通常論文]
  • 川人 宏次, 安達 秀雄, 井野 隆史 日本外科学会雑誌 108 (2) 2007年03月 [査読無し][通常論文]
  • 井上 博睦, 安 隆典, 川人 宏次, 久保 典史, 西田 淳二, 川上 正舒, 齋藤 宗靖 Journal of cardiology 48 (3) 159 -163 2006年 [査読無し][通常論文]
     
    A 40-year-old man presented with massive pulmonary embolism related to diffuse large B cell lymphóma. His hemodynamic state worsened rapidly to shock after sudden onset of dyspnea. Echocardiography and thoracic computed tomography indicated pulmonary thromboembolism due to deep venous thromboembolism, associated with a mass in the anterior mediastinum and a 5 × 8cm mass in the left pelvis compressing the left femoral vein. He underwent emergent surgery to remove a huge thrombus from the right atrium through the bilateral pulmonary arteries. Soon after this surgery, his hemodynamic state recovered and excision of the left cervical lymph node revealed diffuse large B cell lymphoma. Venous compression by the lymphoma mass had caused hemostasis and thrombus formation in the present case.
  • 美島 利昭, 川人 宏次, 村田 聖一郎, 安達 秀雄, 井野 隆史 日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery 14 (6) 639 -644 2005年10月 [査読無し][通常論文]
  • 伊藤 智, 木村 直行, 川人 宏次, 安達 秀雄, 井野 隆史 日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery 14 (4) 563 -567 2005年06月 [査読無し][通常論文]
  • 伊藤 智, 川人 宏次, 田中 正史, 野口 権一郎, 山口 敦司, 村田 聖一郎, 安達 晃一, 安達 秀雄, 井野 隆史 日本心臓血管外科学会雑誌 34 (3) 167 -171 2005年05月 [査読無し][通常論文]
     
    狭小大動脈弁に対する各種19mm機械弁の遠隔期心機能および予後について検討した.1990年から2002年9月までに施行した単独大動脈弁置換術(AVR)295例中で大動脈弁狭窄症(AS)に対し19mm機械弁を使用した46例を対象とし, 予後について検討した.また, 5年以上経過した25例中22例(5∿9年 : 12例, 10年以上 : 10例)に心臓超音波検査を施行した.左室駆出率(LVEF), 左室拡張末期短経(LVDd), 後壁厚(PWT), 心室中隔厚(IVST), 人工弁圧較差(PG)をそれぞれ計測し左室心筋重量(LVm), 左室心筋重量係数(LVMI)を算出し, 術前と遠隔期での結果を比較検討した.平均観察期間は63.1±43.5カ月.在院死亡はなく, 10年生存率が81.4%と良好であった.心機能に関しては保たれNYHAの悪化もなかった.また, 遠隔期に25.0mmHg程度のPGの残存を認めたもののLVm, LVMIの有意な減少を認めた.比較的高齢者や女性が多く, 体表面積(BSA)が小さいこと, 日常生活での運動負荷が少ない患者が多かったことが要因とも考えられるが, 狭小大動脈弁患者の多くは, 小柄な高齢女性であることから, 19mmサイズの弁置換術でも遠隔期のquality of lifeは保たれると思われた.
  • 村田 聖一郎, 川人 宏次, 山口 敦司, 安達 秀雄, 井野 隆史 日本冠疾患学会雑誌 = Journal of the Japanese Coronary Association 10 (2) 85 -88 2004年06月 [査読無し][通常論文]
  • 山口 敦司, 野口 権一郎, 安達 秀雄, 川人 宏次, 村田 聖一郎, 井野 隆史 日本心臓血管外科学会雑誌 33 (2) 73 -76 2004年03月 [査読無し][通常論文]
  • 川人 宏次, 安達 秀雄, 山口 敦司, 村田 聖一郎, 井野 隆史 日本外科学会雑誌 105 (0) 2004年03月 [査読無し][通常論文]
  • 安達 秀雄, 井野 隆史, 川人 宏次, 村田 聖一郎, 安達 晃一 日本外科学会雑誌 105 (0) 2004年03月 [査読無し][通常論文]
  • 山口 敦司, 遠藤 英仁, 川人 宏次, 安達 秀雄, 井野 隆史 日本外科学会雑誌 104 (0) 178 -179 2003年04月 [査読無し][通常論文]
  • 藤本 耕一, 安達 秀雄, 川人 宏次, 山口 敦司, 井野 隆史 日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery 11 (6) 645 -648 2002年10月 [査読無し][通常論文]
  • 鈴木 新太郎, 遠山 信幸, 川人 宏次, 住永 佳久, 小西 文雄 日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 63 (6) 1534 -1536 2002年06月 [査読無し][通常論文]
  • 山口 敦司, 安達 秀雄, 川人 宏次, 安達 晃一, 井野 隆史 日本冠疾患学会雑誌 = Journal of the Japanese Coronary Association 8 (2) 54 -57 2002年06月 [査読無し][通常論文]
  • 川人 宏次, 安達 秀雄, 山口 敦司, 井野 隆史 日本外科学会雑誌 103 (0) 2002年03月 [査読無し][通常論文]
  • 川人 宏次, 安達 秀雄, 山口 敦司, 井野 隆史 日本外科学会雑誌 103 (0) 2002年03月 [査読無し][通常論文]
  • 川人 宏次, 山口 敦司, 坪井 潤一, 由利 康一, 桜川 浩, 藤本 耕一, 田中 正史, 遠藤 英仁, 安達 秀雄, 井野 隆史 日本外科学会雑誌 102 (0) 2001年03月 [査読無し][通常論文]
  • 田中 正史, 川人 宏次, 安達 秀雄, 山口 敦司, 坪井 潤一, 由利 康一, 桜川 浩, 藤本 耕一, 遠藤 英仁, 井野 隆史 日本外科学会雑誌 102 (0) 2001年03月 [査読無し][通常論文]
  • 安達 秀雄, 川人 宏次, 山口 敦司, 村田 聖一郎, 針谷 明房, 安藤 敬, 由利 康一, 坪井 潤一, 井野 隆史 脈管学 40 (6) 311 -315 2000年06月 [査読無し][通常論文]
  • 川人 宏次, 安達 秀雄, 井野 隆史 日本外科学会雑誌 101 (0) 2000年03月 [査読無し][通常論文]
  • 安達 秀雄, 佐藤 政弥, 村田 聖一郎, 岡田 昌彦, 針谷 明房, 坪井 潤一, 川人 宏次, 井野 隆史 脈管学 : 日本脈管学会機関誌 : the journal of Japanese College of Angiology 39 (8) 411 -414 1999年08月 [査読無し][通常論文]
  • 川人 宏次, 三澤 吉雄, 布施 勝生 日本外科学会雑誌 100 (0) 1999年02月 [査読無し][通常論文]
  • 村田 聖一郎, 川人 宏次, 井野 隆史, 安達 秀雄, 針谷 明房, 佐藤 政弥, 岡田 昌彦, 坪井 潤一 日本外科学会雑誌 100 (0) 1999年02月 [査読無し][通常論文]
  • 安達 秀雄, 村田 聖一郎, 岡田 昌彦, 坪井 潤一, 針谷 明房, 佐藤 政弥, 川人 宏次, 井野 隆史 日本外科学会雑誌 100 (0) 1999年02月 [査読無し][通常論文]
  • 三澤 吉雄, 布施 勝生, 川人 宏次 日本外科学会雑誌 100 (0) 1999年02月 [査読無し][通常論文]
  • K Kawahito, E Kobayashi, H Iwasa, Y Misawa, K Fuse ANNALS OF THORACIC SURGERY 67 (1) 79 -84 1999年01月 [査読無し][通常論文]
     
    Background. In regard to postoperative bleeding, the most important consequence of cardiopulmonary bypass (CPB) is the loss of aggregability. However, the mechanism of platelet aggregation loss during CPB is unclear. Newly developed particle-counting methods that use light scattering can be used to quantify changes in the number of platelet aggregates of different sizes after application of an aggregating stimulus. Using a lightscattering method, we investigated changes in platelet aggregation during cardiac operation. Methods. Nineteen patients undergoing CPB were evaluated. Blood samples were obtained before the operation, 1 hour after initiation of CPB, at the end of CPB, at the end of the operation, and on day 1 after the operation. Platelet aggregation after stimulation by 2.5 mu mol/L adenosine diphosphate and 2.0 mu g/mL collagen was determined; small (9 to 25 mu m), medium (25 to 50 mu m), and large (50 to 70 mu m) aggregates were counted. Results. Generation of medium and large aggregates after stimulation with adenosine diphosphate and collagen were significantly decreased with CPB, whereas, in spite of hemodilution, the quantity of the small aggregates was maintained at the elevated level. Conclusions. These results reflect the fact that CPB does not affect the first phase of aggregation. It suggests that platelet dysfunction associated with CPB is mainly caused by an inhibition in the development of small aggregates into larger aggregates. (C) 1999 by The Society of Thoracic Surgeons.
  • 斉藤 力, 川人 宏次, 長谷川 伸之, 三澤 吉雄, 加藤 盛人, 布施 勝生 日本心臓血管外科学会雑誌 27 (6) 360 -363 1998年11月 [査読無し][通常論文]
  • 三澤 吉雄, 布施 勝生, 川人 宏次, 小西 宏明 人工臓器 27 (2) 578 -581 1998年04月 [査読無し][通常論文]
     
    CAPIOX EBS is a newly developed heparin-coated system for percutaneous cardiopulmonary support. Ten patients were assisted by this system after cardiac surgery because of low cardiac output syndrome in our institute, and 18 kits of CAPIOX EBS were installed in these patients. Non of the 18 kits showed any troublesome within 24 h of circulatory assist, but 6 kits were replaced over 36 h of circulatory assist because of hemolysis, annoying noise from the pump, or impaired oxygenation. Out of these 6 kits, two pumps revealed blood clot formation at the outlet and another two oxygenators showed plasma leakage. The mean running period of the other twelve kits was 142h (2-194h), and they did not show any functional waning. We needed 5 to 10 min for kit exchange, and hemodynamic deterioration during the procedure was minimal, and all patients requiring a new kit regained stable hemodynamic state immediately after kit exchange.
  • 三澤 吉雄, 布施 勝生, 小西 宏明, 加藤 盛人, 上沢 修, 齋藤 力, 川人 宏次, 登坂 直規, 齋藤 紀子, 大谷 真一, 福田 稔 日本外科学会雑誌 99 (0) 1998年03月 [査読無し][通常論文]
  • 川人 宏次, 小林 英司, 原田 和博, 大森 正規, 鬼頭 康彦, 三澤 吉雄, 藤村 昭夫, 布施 勝生 日本外科学会雑誌 99 (0) 1998年03月 [査読無し][通常論文]
  • Surg today 28 (9) 971 -973 1998年 [査読無し][通常論文]
  • Arch Surg 133 216 -7 1998年 [査読無し][通常論文]
  • Extracorporeal membrane oxygenation support and cytokines
    Ann Thorac Surg 65 1192 -3 1998年 [査読無し][通常論文]
  • トピックス-経皮的心肺補助装置(PCPS)
    メジカルビュー 32 1998年 [査読無し][通常論文]
  • Ann Thorac Surg 66 982 -3 1998年 [査読無し][通常論文]
  • 長谷川 伸之, 布施 勝生, 上沢 修, 加藤 盛人, 三澤 吉雄, 川人 宏次 日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery 6 (6) 763 -767 1997年10月 [査読無し][通常論文]
  • 川嶋 隆久, 上沢 修, 大木 伸一, 長谷川 伸之, 小西 宏明, 川人 宏次, 登坂 直規, 三澤 吉雄, 加藤 盛人, 布施 勝生 日本心臓血管外科学会雑誌 26 (5) 318 -321 1997年09月 [査読無し][通常論文]
  • 川人 宏次, BENKOWSKI Robert, 大坪 諭, 布施 勝生, 能勢 之彦, DEBAKEY Michael E 人工臓器 26 (3) 806 -810 1997年06月 [査読無し][通常論文]
     
    We introduce the computer technology to enable an accurate, efficient, and reliable design process of an implantable axial flow VAD. The device design is computer-modeled with a parametric solid modeler. To eliminate the high negative pressure area, we performed computational fluid stress analysis on pump design. To improve efficiency and anti-thrombogenicity, CFD (computational fluid dynamics) study is performed to determine pressure and velocity of the fluid in the pump and eliminate the stagnant areas. Machining paths for prototype fabrication are generated using CAM software. And they are machined using CNC (computer numerically controlled) milling machine. Hemolytic characteristics was dramatically improved to 0.002g/100L of normalized index of hemolysis. Total system efficiency was improved to 14%. And Ex vivo 2 week implantation demonstrated excellent anti-thrombogenicity. The use of the CAD/CAM/CAE made it possible to develop a VAD rapidly and successfully.
  • 川嶋 隆久, 上沢 修, 大木 伸一, 長谷川 伸之, 川人 宏次, 布施 勝生 日本血管外科学会雑誌 = The Japanese journal of vascular surgery : official journal of the Japanese Society for Vascular Surgery 6 (1) 71 -74 1997年02月 [査読無し][通常論文]
  • Hemolysis in different centrifugal pumps
    Artif Organs 21 323 -6 1997年 [査読無し][通常論文]
  • Platelet damage caused by the centrifugal pump : in vitro evaluation by measuring the release of α-granule packing proteins
    Artif Organs 21 1105 -9 1997年 [査読無し][通常論文]
  • Improved flow straightener reduce thrombus in the NASA/DeBakey axial flow ventricular assist device
    Artif Organs 21 339 -43 1997年 [査読無し][通常論文]
  • Ex vivo evaluation of the NASA/DeBakey axial flow ventricular assist device. Results of a 2 week screening test
    ASAIO J 42 M754-7 1996年 [査読無し][通常論文]
  • Surgery Today(Jpn J Surg) 26 (8) 652 -654 1996年 [査読無し][通常論文]
  • K Kawahito, G Damm, R Benkowski, G Aber, J Bacak, K Tasai, T Shimono, S Takatani, Y Nose, GP Noon, ME DeBakey ARTIFICIAL ORGANS 20 (1) 47 -52 1996年01月 [査読無し][通常論文]
     
    A small ventricular assist device intended for long-term implantation has been developed by a cooperative effort between the Baylor College of Medicine and the NASA/Johnson Space Center. To date, in vitro tests have been performed to address hemolysis and pump performance issues. In this Phase 1 study, we assessed the durability and atraumatic features aiming for 2 day implantation. Eight pumps were implanted in 2 calves as paracorporeal left ventricular assist devices. The pump running times ranged from 18 to 203 h (78.1 +/- 23.7; mean +/- SEM). All the pump implantations were terminated because of thrombus formation. Plasma-free hemoglobin levels were below 13.7 mg/dl, except for 1 case complicated by inflow cannula obstruction. The pump speed was maintained between 10,100 and 11,400 rpm. Pump outputs were from 3.6 to 5.2 L/min. The electrical power required by the system ranged between 9 and 12 W. Clinically there was no detectable organ dysfunction noted, and postmortem evaluation demonstrated no pump related adverse effects in either calf except for small kidney infarctions. Thrombus deposition was observed mainly at the hub portions and the now straightener.
  • Phase 1 ex vivo studies of the Baylor/NASA axial flow ventricular assist device
    Artficial Heart5, Springer-Verlag Tokyo 245 -252 1996年 [査読無し][通常論文]
  • 川人 宏次 血管 18 (3) 99 -106 1995年08月 [査読無し][通常論文]
  • K KAWAHITO, K TASAI, S MURATA, A YAMAGUCHI, A MIZUHARA, H ADACHI, T INO ARTIFICIAL ORGANS 19 (8) 857 -863 1995年08月 [査読無し][通常論文]
     
    A new antithrombogenic material was studied, fluorine-acryl-styrene-urethane-silicone (FASUS) copolymer, the theoretical basis of which attributed to its hydrophilic and hydrophobic microdomain structure. In this series of experiments, the blood compatibility of this copolymer was evaluated in vitro and ex vivo. For the in vitro evaluation, a whole blood clotting test and the microsphere column test were performed. For the ex vivo evaluation, two series of shunt tests in rabbits were performed, one was the arterioartery (A-A) shunt model, and the other was the arteriovenous (A-V) shunt model. The antithrombogenicity was assessed by measuring the shunt obstructive time in the A-A shunt experiment. The A-V shunt experiment was assessed by measuring the circulating platelet counts, platelet aggregability, activated partial thromboplastin time (APTT), and prothrombin time (PT). In the whole blood clotting test, FASUS revealed the significantly longer blood clotting time than that of the control glass tubings (19.7 +/- 1.0 versus 6.5 +/- 0.7 min, p < 0.001). In the microsphere column test, the coated group had a 30% reduction of the platelet number in the eluted blood in contrast with a marked decrease of 70% in the control group (p < 0.05). In the ex vivo A-A shunt experiment, the occlusion time for the FASUS-coated group was significantly longer than that of the control (109.7 +/- 17.3 versus 3.0 +/- 0.4 min, p < 0.05). The A-V shunt experiment showed that the FASUS copolymer suppressed the decrease in platelet counts and tended to improve prolonged APTT compared with that of the control. Clinically, in 25 patients, we placed coated FASUS copolymer into the cannulas for use in percutaneous cardiopulmonary support (PCPS) procedures. There was no evidence of thrombus on the blood contacting surface and no thromboembolism in major organs clinically or upon postmortem examination. In summary, this new copolymer may be effective in preventing thrombus formation in vitro, ex vivo, and in clinical situations.
  • K KAWAHITO, M KAWAKAMI, T FUJIWARA, H ADACHI, T INO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 110 (1) 99 -102 1995年07月 [査読無し][通常論文]
     
    Cardiac operations with cardiopulmonary bypass cause a systemic inflammatory response. Neutrophils and monocytes-macrophages play an important role in triggering the initiation of the inflammatory response. Recently, some kinds of cytokines that are powerful leukocyte chemotactic factors have been characterized concerning an inflammatory response: interleukin-8 has a potent chemoattractant activity for neutrophils, and monocyte chemoattractant factor has monocyte-macrophage chemotactic activity, To investigate the possible roles of the cytokines in the inflammatory response in cardiopulmonary bypass, 12 adult patients undergoing cardiopulmonary bypass were studied for measurement of interleukin-8 and monocyte chemoattractant factor, Systemic blood was collected before cardiopulmonary bypass, at the end of cardiopulmonary bypass, and at 3, 12, 24, and 48 hours after cardiopulmonary bypass from the patients' radial arteries, Significant increases in levels of interleukin-8 and monocyte chemoattractant factor were detected with a peak level at 3 hours after bypass compared with levels before cardiopulmonary bypass (p < 0.05). This study demonstrated that interleukin-8 and monocyte chemoattractant factor are released into the circulation after adult hypothermic cardiopulmonary bypass and reach a maximum level 3 hours after bypass.
  • 小林 信彦, 久保 典史, 藤井 幹久, 勝木 孝明, 大村 延博, 斉藤 宗靖, 山口 敦司, 川人 宏次, 井野 隆史 Japanese circulation journal 59 (0) 1995年06月 [査読無し][通常論文]
  • 安達 秀雄, 村田 聖一郎, 水原 章浩, 山口 敦司, 紙尾 均, 川人 宏次, 井野 隆史 人工臓器 24 (3) 878 -881 1995年06月 [査読無し][通常論文]
     
    Open proximal anastomosis with hypothermic circulatory arrest was used for the replacement of descending aorta in 7 patients. Left heart bypass and partial cardiopulmonary bypass with anti-thrombotic system were also used in 7 and 6 patients, respectively. These three systems were compared with each other in terms of the results of treatment and clinical usefulness. One patient with left heart bypass and two patients with partial cardiopulmonary bypass died due to the thrombosis by the aortic clamp and the aortic dissection by the trouble of anastomosis. One patient with open anastomosis died due to LOS despite of uneventful anastomosis. Open proximal anastomosis may be useful for the patient with the aortic pathology extended to the distal aortic arch. The patient with aortic dissection in the descending aorta may be also a good candidate for this method.
  • K KAWAHITO, H ADACHI, T INO, H IDE, A MIZUHARA, A YAMAGUCHI VASCULAR SURGERY 29 (2) 153 -157 1995年03月 [査読無し][通常論文]
     
    A forty-four-year-old woman presented with a DeBakey-type IIIb dissecting aneurysm, multiple aneurysmal dilatation of the coronary arteries, and a ''string-of-beads'' appearance of the peripheral arteries (due to cystic medial necrosis and intimal hyperplasia). Upon assessment of her family history and multiple vascular involvement secondary to cystic medial necrosis, an incomplete Marfan's syndrome was suggested. This rare case of multiple aneurysmal changes to the great and peripheral arteries is presented with special reference to the radiographic and morphologic manifestations.
  • Proinflammatory cytokine levels in patients undergoing cardiopulmonary bypass. Does lung reperfusion influence the release of cytokines?
    ASAIO J 41 M775-778 1995年 [査読無し][通常論文]
  • K. Kawahito, T. Ino, H. Adachi, H. Ide, A. Mizuhara, A. Yamaguchi ASAIO Journal 40 (4) 972 -976 1994年10月 [査読無し][通常論文]
     
    To overcome the hemorrhagic complications that may occur during extracorporeal circulatory support for post cardiotomy shock patients, a heparinized circuit was introduced into the percutaneous cardiopulmonary support system and decreased systemically administered heparin during bypass. Heparin coated percutaneous cardiopulmonary support with low dose systemic heparinization was instituted in 13 patients (6 men and 7 women, mean age 62.2 ± 8.5 years) who experienced circulatory collapse after cardiac surgery. Of the 13 patients, 9 could not be weaned from cardiopulmonary bypass and 4 had circulatory collapse in the operating room or in the intensive care unit. The duration of support ranged from 1 to 66 hr (mean 27.4 ± 26.7), and the flow rate ranged from 1 to 3 L/min (2.2 ± 0.5). An activated coagulation time of about 150 sec was maintained with or without minimal systematically administered heparin. Of the patients cannulated, 77% (10 of 13) were successfully weaned from percutaneous cardiopulmonary support and 39% (5 to 13) were long-term survivors. The causes of death were sepsis in three, progressive heart failure in three, lower leg ischemia in one, and vital infection in one. From the results of clinical or post mortem examinations, there was no massive bleeding or evidence of thromboembolism in the major organs. From observations made within 12 hr of initiation of percutaneous cardiopulmonary support, there was no significant decrease in the number of platelets, but platelet count had significantly decreased 24 hr after initiation. The authors' experience indicates that heparin coated percutaneous cardiopulmonary support with low dose systemic heparinization is beneficial for circulatory assist in circulatory collapse after cardiac surgery because of its simplicity and antithrombogenicity, which thus avoids the risk of bleeding complications.
  • 体外循環回路の抗血栓性材料の開発
    3 192 -193 1994年 [査読無し][通常論文]
  • 原発性右房血管肉腫の1例
    日本胸部外科学会雑誌 42 1069 -1072 1994年 [査読無し][通常論文]
  • Inferior vena caval tumor thrombus from renal angiomyolipoma-a case report
    Vascular Surgery 28 213 -218 1994年 [査読無し][通常論文]
  • 川人 宏次, 井手 博文, 井野 隆史, 安達 秀雄, 水原 章浩, 山口 敦司 日本心臓血管外科学会雑誌 23 (1) 15 -20 1994年 [査読無し][通常論文]
  • 川人 宏次, 井野 隆史, 安達 秀雄, 井手 博文, 水原 章浩, 山口 敦司, 村田 聖一郎 人工臓器 23 (3) 612 -617 1994年 [査読無し][通常論文]
  • 来院時心肺停止症例に対するPCPS(Percutaneous Cadiopulmonary Support)を用いた蘇生術
    日本胸部外科学会雑誌 42 121 -125 1994年 [査読無し][通常論文]
  • 川人 宏次, 井野 隆史, 安達 秀雄, 井手 博文, 水原 章浩, 山口 敦司, 村田 聖一郎 人工臓器 23 (3) 712 -716 1994年 [査読無し][通常論文]
  • 川人 宏次, 井野 隆史, 安達 秀雄, 井手 博文, 水原 章浩, 山口 敦司, 村田 聖一郎 人工臓 23 (1) 102 -106 1994年 [査読無し][通常論文]
  • A new antithrombogenic coating material"Fluorine-acryl-styrene-urethane-silicone graft-block copolymer" for a circulatory assist device. Heart Replacement.
    Artificial Heart4 Springer-Verlag 37 -40 1993年 [査読無し][通常論文]
  • 新しい抗血栓性材料を用いた抗血栓性経皮的補助循環システムの開発
    日本胸部外科学会雑誌 41 1467 -1477 1993年 [査読無し][通常論文]
  • Aberrant right subclavian artery aneurysmの1手術例
    41 148 -152 1993年 [査読無し][通常論文]
  • 緊急 大動脈弁置換術直後に僧帽弁逆流の改善が経食道ドップラエコーで確認された大動脈弁狭窄症の1例
    日本画像医学会雑誌 13 253 -258 1992年 [査読無し][通常論文]
  • 日本臨床外科医学会雑誌 53 2948 -2952 1992年 [査読無し][通常論文]
  • 新しい抗血栓性材料を用いたV-Aバイパスからの1離脱例
    日本胸部外科学会雑誌 40 1110 -1115 1992年 [査読無し][通常論文]
  • 胆道再建術式としての肝管十二指腸吻合術の検討
    外科 53 735 -738 1991年 [査読無し][通常論文]
  • Mycobacterium fortuitumによる開心術後縦隔炎の4治験例
    日本胸部臨床 50 508 -512 1991年 [査読無し][通常論文]
  • 日本消化器外科学会雑誌 24 2457 -2460 1991年 [査読無し][通常論文]
  • 血清中および嚢胞内CA19-9,SLXが高値を示した胸腺嚢腫の1手術例
    日本胸部臨床 49 841 -845 1990年 [査読無し][通常論文]
  • Bullaの経過観察中に嚢胞壁に発生した肺癌の1切除例
    外科 52 527 -530 1990年 [査読無し][通常論文]
  • 外傷性三尖弁閉鎖不全症の1治験例
    胸部外科 42 1047 -1049 1989年 [査読無し][通常論文]

受賞

  • 1995年 Innovative Research Award The International Society for Rotary Blood pumps

共同研究・競争的資金等の研究課題

  • Study on Mechanical Circulatory Support
  • 機械的補助循環に関する研究

委員歴

  • 1995年   The International Society for Rotary Blood Pumps   International Scientific Board   The International Society for Rotary Blood Pumps


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