研究者総覧

吉野 義一 (ヨシノ ヨシカズ)

  • 中央診療部脳血管内治療部 教授
Last Updated :2020/07/29

研究者情報

学位

  • 医学博士(東京医科歯科大学)

学位

    吉野 義一

ホームページURL

科研費研究者番号

  • 70323681

J-Global ID

研究活動情報

論文

  • Ishibashi T, Toyama S, Miki K, Karakama J, Yoshino Y, Ishibashi S, Tomita M, Nemoto S
    Journal of clinical monitoring and computing 2019年01月 [査読有り][通常論文]
  • Sumita K, Karakama J, Makita I, Miki K, Yoshino Y, Yoshimura M, Maehara T, Nemoto S
    No shinkei geka. Neurological surgery 46 10 911 - 916 2018年10月 [査読有り][通常論文]
  • Shihori Hayashi, Taketoshi Maehara, Maki Mukawa, Masaru Aoyagi, Yoshikazu Yoshino, Shigeru Nemoto, Toshiaki Ono, Kikuo Ohno
    NEUROLOGIA MEDICO-CHIRURGICA 54 2 150 - 154 2014年02月 [査読有り][通常論文]
     
    Ruptured intracranial aneurysms are rare in the pediatric population compared to adults. This has incited considerable discussion on how to treat children with this condition. Here, we report a child with a ruptured saccular basilar artery aneurysm that was successfully treated with coil embolization. A 12-year-old boy with acute lymphoblastic leukemia and accompanying abdominal candidiasis after chemotherapy suddenly complained of a severe headache and suffered consciousness disturbance moments later. Computed tomography scans and cerebral angiography demonstrated acute hydrocephalus and subarachnoid hemorrhage caused by saccular basilar artery aneurysm rupture. External ventricular drainage was performed immediately. Because the patient was in severe condition and did not show remarkable signs of central nervous system infection in cerebrospinal fluid studies, we applied endovascular treatment for the ruptured saccular basilar artery aneurysm, which was successfully occluded with coils. The patient recovered without new neurological deficits after ventriculoperitoneal shunting. Recent reports indicate that both endovascular and microsurgical techniques can be used to effectively treat ruptured cerebral aneurysms in pediatric patients. A minimally invasive endovascular treatment was effective in the present case, but long-term follow-up will be necessary to confirm the efficiency of endovascular treatment for children with ruptured saccular basilar artery aneurysms.
  • Iwasawa E, Ishibashi S, Miki K, Yoshino Y, Nemoto S, Mizusawa H
    Neurology 81 6 e38 - 9 2013年08月 [査読有り][通常論文]
  • Naoki Otani, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Yoshikazu Yoshino, Hiroshi Yatsushige, Hiroki Miyawaki, Kyoko Sumiyoshi, Takashi Sugawara, Aoyagi Chikashi, Satoru Takeuchi, Goh Suzuki
    WORLD NEUROSURGERY 75 1 73 - 77 2011年01月 [査読有り][通常論文]
     
    OBJECTIVE: This report presents 12 consecutively managed patients with aneurysmal subarachnoid hemorrhage (SAH) associated with acute subdural hematoma (ASDH) who underwent decompressive craniectomy (DC) with special attention to their clinical characteristics and surgical outcomes. METHODS: We retrospectively reviewed medical charts, radiologic findings, surgical notes, and video records. RESULTS: Among these 12 patients (mean age 59.1 years, 4 men, 8 women), the Hunt and Kosnik clinical grade was grade V in 7 patients (58.3%), grade IV in 2 patients (16.7%), grade III in 2 patients (16.7%), and grade II in 1 patient (8.3%). The aneurysms were located on the internal carotid artery in four patients, the middle cerebral artery in six patients, and the anterior communicating artery in two patients. Computed tomography findings on admission revealed ASDH in all patients. In addition, SAH was seen in 11 patients. An intracerebral hematoma was found in eight patients, intraventricular hemorrhaging occurred in four, and an acute hydrocephalus was seen in one patient. All patients underwent a microsurgical clipping procedure and an additional DC. Symptomatic vasospasm was confirmed in six (50%), and eight patients with chronic hydrocephalus received a ventriculoperitoneal shunt (67%). The Glasgow Outcome Scale at discharge showed good recovery in five patients (41.7%), severe disability in four (33.3%), vegetative state in two (16.7%), and death in one patient (8.3%). A favorable outcome was achieved in five patients (41.7%). CONCLUSIONS: We suggest that the DC was effective for reducing morbidity and mortality in poor grade patients with SAH presenting with ASDH.
  • Satoru Takeuchi, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Naoki Otani, Yoshikazu Yoshino, Hiroshi Yatsushige, Takashi Sugawara
    JOURNAL OF ANESTHESIA 24 2 315 - 316 2010年04月 [査読有り][通常論文]
  • Satoru Takeuchi, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Naoki Otani, Yoshikazu Yoshino, Hiroshi Yatsushige, Takashi Sugawara
    JOURNAL OF CLINICAL NEUROSCIENCE 17 3 377 - 378 2010年03月 [査読有り][通常論文]
     
    Hypereosinophilic syndrome (HES) is a rare disorder that can cause ischemic stroke. We present a patient with middle cerebral artery (MCA) occlusion resulting from HES. Transarterial thrombolysis resulted in MCA recanalization and adjuvant therapy may have contributed to stabilization of the underlying HES in our patient. (C) 2009 Elsevier Ltd. All rights reserved.
  • Naoki Otani, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Yoshikazu Yoshino, Hiroshi Yatsushige, Hiroki Miyawaki, Kyoko Sumiyoshi, Takashi Sugawara, Aoyagi Chikashi, Satoru Takeuchi, Go Suzuki
    BRAIN EDEMA XIV 106 257 - 260 2010年 [査読有り][通常論文]
     
    Acute subdural hematoma (ASDH) patients presenting in a severe condition tend to have poor outcomes due to the significant brain edema required to maintain the ICP at less than 20-25 mmHg. This study compared the surgical outcomes of 16 critically ill patients with ASDH who underwent hematoma irrigation with trephination therapy (HITT) based on their initial ICP values. The initial mean GCS score upon admission was four. A unilateral dilated pupil was seen in one and bilateral dilated pupils were seen in seven patients. The co-existence of a brain contusion was seen in seven patients, brain swelling was noted in six patients, and both basal cistern effacement and a midline shift greater than 5 mm were observed in all patients. The mean initial ICP value was 45 mmHg (range: 3 to 85 mmHg). Ten patients (62.5%) underwent a rapid external decompression to evacuate the hematoma. By using the Glasgow Outcome Scale upon discharge a score of good recovery (GR) was assigned to two (12.5%), moderate disability (MD) to four (25.0%), vegetative state (VS) to two (12.5%), and death (D) to eight (50.0%) patients. All six patients who showed an initial ICP greater than 60 mmHg died despite intensive care. Eight patients who showed an initial ICP less than 40 mmHg had a favorable outcome, but two patients deteriorated due to a traumatic cerebrovascular disorder. It seems that the initial ICP monitoring with HITT for ASDH patients in critical condition may be an important factor for predicting both surgical outcome and clinical course.
  • Naoki Otani, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Yoshikazu Yoshino, Hiroshi Yatsushige, Hiroki Miyawaki, Kyoko Sumiyoshi, Takashi Sugawara, Aoyagi Chikashi, Satoru Takeuchi, Go Suzuki
    BRAIN EDEMA XIV 106 261 - + 2010年 [査読有り][通常論文]
     
    Acute epidural hematomas (AEDH) are generally managed with rapid surgical hematoma evacuation and bleeding control. However, the surgical outcome of patients with serious brain edema is poor. This study reviewed the clinical outcome for AEDH patients and evaluated the efficacy of the DC, especially in patients with associated massive brain swelling. Eighty consecutive patients surgically treated with AEDH were retrospectively assessed. The patients were divided into two groups: (a) hematoma evacuation (HE: 46 cases) and (b) HE+ an external decompression (ED: 34 cases). The medical charts, operative findings, radiological findings, and operative notes were reviewed. In the poor outcome group, there were 18 patients (72%), with a GCS score of less than 8 (severe injury), and 22 patients (88%) who showed pupil abnormalities. Many more patients showed a midline shift, basal cistern effacement, and brain contusion in comparison to the favorable outcome group. In the favorable outcome group, almost all of the patients (98%) showed less than 12 mm of a midline shift. The influential factors may be age, GCS, pupil abnormalities, size, midline shift, basal cistern effacement, coincidence of contusion and swelling. We conclude that an A DC may be effective to manage the AEDH patients with cerebral contusion or massive brain swelling.
  • Hiroshi Yatsushige, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Naoki Otani, Yoshikazu Yoshino, Kyoko Sumiyoshi, Takashi Sugawara, Hiroki Miyawaki, Chikashi Aoyagi, Satoru Takeuchi, Go Suzuki
    BRAIN EDEMA XIV 106 265 - 270 2010年 [査読有り][通常論文]
     
    Purpose Decompressive craniectomy for traumatic brain injury patients has been shown to reduce intracranial hypertension, while it often results in increased brain edema and/or contralateral space-occupied hematoma. The purpose of this study was to determine the prognosis of bilateral decompressive craniectomy in severe head injury patients with the development of either bilateral or contralateral lesions after ipsilateral decompressive craniectomy. Methods Twelve patients underwent bilateral decompressive craniectomy among 217 individuals who had been treated with decompressive craniectomy with dural expansion from September 1995 to August 2006. The following patient data were retrospectively collected: age, neurological status at admission, time between injury and surgical decompression, time between first and second decompression, laboratory and physiological data collected in the intensive care unit, and outcome according to the Glasgow Outcome Scale. Results Patient outcomes fell into the following categories: good recovery (three patients); mild disability (one patient); severe disability (two patients); persistent vegetative state (one patient); and death (five patients). Patients with good outcomes were younger and had better pupil reactions and neurological statuses on admission. Other factors existing prior to the operation did not directly correlate with outcome. At 24 h post-surgery, the average intercranial pressure (ICP), cerebral perfusion pressure (CPP), glucose level, and lactate level in patients with poor outcomes differed significantly from those of patients with a good prognosis. Conclusion Head injury patients with either bilateral or contralateral lesions have poor prognosis. However, bilateral decompressive craniectomy may be a favorable treatment in certain younger patients with reactive pupils, whose ICP and CPP values are stabilized 24 h post-surgery.
  • Satoru Takeuchi, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Naoki Otani, Yoshikazu Yoshino, Hiroshi Yatsushige, Takashi Sugawara
    JOURNAL OF CLINICAL NEUROSCIENCE 17 1 153 - 154 2010年01月 [査読有り][通常論文]
     
    Epstein-Barr virus (EBV) encephalitis is a rare neurological complication, usually only reported in pediatric patients. We present a 20-year-old, previously healthy male who developed hemorrhagic encephalitis caused by EBV. He was admitted to our hospital with a I-week history of fever, diarrhea, headache, and confusion, Brain T2-weighted MRI showed a focal area of increased signal in the right temporal lobe. Brain MRI and CT scans on day 2 revealed progression of the lesion, with partial hemorrhagic change, acute brain swelling, and severe midline shift. The patient underwent external decompression and external ventricular drainage. EBV DNA was identified in brain biopsy specimens by polymerase chain reaction. The postoperative course was uneventful. To Our knowledge, this is the second report of hemorrhagic EBV encephalitis in an adult. Published by Elsevier Ltd.
  • [Unusual distribution of blood in a ruptured aneurysm--case report].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H, Sugawara T
    Brain and nerve = Shinkei kenkyu no shinpo 61 12 1425 - 1428 2009年12月 [査読有り][通常論文]
  • Satoru Takeuchi, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Naoki Otani, Yoshikazu Yoshino, Hiroshi Yatsushige, Takashi Sugawara
    ACTA NEUROCHIRURGICA 151 11 1513 - 1515 2009年11月 [査読有り][通常論文]
     
    We report a rare case of chronic encapsulated intracerebral hematoma (CEIH) after radiosurgery for a cerebral arteriovenous malformation (AVM). Seven years after radiosurgery, magnetic resonance imaging revealed a high-intensity mass in the right basal ganglia with a peripheral low signal ring and fluid level on both T1- and T2-weighted images, which was compatible with CEIH. Stereotactic evacuation and placement of an Ommaya reservoir were performed. The concentration of vascular endothelial growth factor was high in the hematoma, suggesting that CEIH may be similar to chronic subdural hematoma.
  • Satoru Takeuchi, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Naoki Otani, Yoshikazu Yoshino, Hiroshi Yatsushige, Takashi Sugawara
    JOURNAL OF CLINICAL NEUROSCIENCE 16 10 1344 - 1346 2009年10月 [査読有り][通常論文]
     
    Dolichoectasia is an angiopathy characterized by dilatation, elongation, and tortuosity of the brain arteries. It most frequently involves the vertebral and basilar arteries; involvement of both the vertebrobasilar and carotid systems is rare. We present a patient with fatal dolichoectasia involving both the vertebrobasilar and carotid artery systems. (C) 2009 Elsevier Ltd. All rights reserved.
  • [Case of ruptured middle cerebral artery bifurcation aneurysm presenting as putaminal hemorrhage without subarachnoid hemorrhage].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H, Sugawara T
    Brain and nerve = Shinkei kenkyu no shinpo 61 10 1171 - 1175 2009年10月 [査読有り][通常論文]
  • [A case of traumatic middle meningeal arteriovenous fistula on the side of the head opposite to the injured side].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H, Sugawara T, Aoyagi C, Suzuki G
    No shinkei geka. Neurological surgery 37 10 983 - 986 2009年10月 [査読有り][通常論文]
  • Naoki Otani, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Yoshikazu Yoshino, Hiroshi Yatsushige, Kyoko Sumiyoshi, Hiroki Miyawaki, Chikashi Aoyagi, Satoru Takeuchi, Go Suzuki
    JOURNAL OF CLINICAL NEUROSCIENCE 16 8 1018 - 1023 2009年08月 [査読有り][通常論文]
     
    Ruptured aneurysms located at the non-branching sites of the internal carotid artery, including blister-like aneurysms, possess unique clinical and technical features. This report presents nine consecutively managed patients with these types of aneurysm, detailing the clinical and radiological characteristics and surgical Outcomes. The initial angiography identified aneurysmal lesions in six of the nine patients with two of these patients requiring additional three-dimensional (3D) angiography. In three patients the aneurysm was only diagnosed on second or third angiograms. Six patients had blister-like aneurysms, and two had saccular-shaped aneurysms diagnosed on the basis of intraoperative findings. One patient with a saccular aneurysm died without surgery. Eight patients underwent a microsurgical procedure: clipping in five, clipping on wrapping with suturing in two and trapping in one. Three of these eight patients had an intraoperative rupture. A favorable Outcome was obtained in seven patients. Advances in microsurgical techniques to prevent premature rupture and 3D radiological diagnosis with careful pre-operative consideration of the surgical Strategies will be required for a further improvement of the clinical outcome. (C) 2008 Elsevier Ltd. All rights reserved.
  • [A case of cerebral venous thrombosis associated with thrombocythemia].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H, Sugawara T
    No shinkei geka. Neurological surgery 37 7 697 - 702 2009年07月 [査読有り][通常論文]
  • Naoki Otani, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Yoshikazu Yoshino, Hiroshi Yatsushige, Kyoko Sumiyoshi, Hiroki Miyawaki, Chikashi Aoyagi, Satoru Takeuchi, Go Suzuki
    JOURNAL OF CLINICAL NEUROSCIENCE 16 6 802 - 806 2009年06月 [査読有り][通常論文]
     
    Optimal surgical management of ruptured aneurysms of the distal anterior cerebral artery continues to provide unique technical challenges. This study presents 20 consecutively managed such patients, with special attention given to the clinical and radiological characteristics, as well as the surgical outcomes. Intracerebral hematoma was seen in 11 of the 20 patients, and intraventricular hemorrhage occurred in 4 (20%). Angiography revealed that 9 (45%) patients had multiple aneurysms. Three patients (15%) had "mirror" distal anterior cerebral arterial aneurysms on the contralateral side. Eleven patients (55%) had aneurysms located at the supracallosal portion of the anterior cerebral artery, while 9 patients (45%) had aneurysms located below the genu of the corpus callosum. The mean aneurysmal diameter was 3.85 mm; 18 aneurysms (90%) were less than 6 mm in diameter. Eighteen patients (90%) underwent a microsurgical procedure; 2 (10%) underwent endovascular coiling due to poor clinical grade. A favorable outcome was achieved in 14 (70%) patients. Advances in microsurgical techniques will be required to further improve clinical outcome. Published by Elsevier Ltd.
  • [A case of meningitis complicated by brainstem infarction].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H, Sugawara T, Aoyagi C, Suzuki G
    No shinkei geka. Neurological surgery 37 6 591 - 595 2009年06月 [査読有り][通常論文]
  • [Trapping of ruptured dissecting aneurysm of distal anterior inferior cerebellar artery--case report].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    Brain and nerve = Shinkei kenkyu no shinpo 61 2 203 - 207 2009年02月 [査読有り][通常論文]
  • Yoji Tanaka, Tadashi Nariai, Toshiya Momose, Masaru Aoyagi, Taketoshi Maehara, Toshiki Tomori, Yoshikazu Yoshino, Tsukasa Nagaoka, Kiichi Ishiwata, Kenji Ishii, Kikuo Ohno
    JOURNAL OF NEUROSURGERY 110 1 163 - 172 2009年01月 [査読有り][通常論文]
     
    Object. A miltimodal neuronavigation system using metabolic images with PET and anatomical images from MR images is described here for glioma surgery. The efficacy of the multimodal neuronavigation system was evaluated by comparing the results with that of the conventional navigation system, which routinely uses anatomical images from MR and CT imaging as guides. Methods. Thirty-three patients with cerebral glioma underwent 36 operations with the aid of either a multimodal or conventional navigation system. All of the patients were preliminarily examined using PET with L-methyl-[(11)C] methionine (MET) for surgical planning. Seventeen of the operations were performed with the multimodal navigation system by integrating the MET-PET images with anatomical MR images. The other 19 operations were performed using a conventional navigation system based solely on MR imaging. Results. The multimodal navigation system proved to be more useful than the conventional navigation system in determining the area to be resected by providing a clearer tumor boundary, especially in cases of recurrent tumor that had lost a normal gyral pattern. The multimodal navigation system was therefore more effective than the conventional navigation system in decreasing the mass of the tumor remnant in the resectable portion. A multivariate regression analysis revealed that the multimodal navigation systern-guided Surgery benefited patient survival significantly more than the conventional navigation-guided surgery (p = 0.016, odds ratio 0.52 [95% confidence interval 0.29-0.88]). Conclusions. The authors' preliminary intrainstitutional comparison between the 2 navigation systems suggested the possible premise of multimodal navigation. The multimodal navigation system using MET-PET fusion imaging is an interesting technique that may prove to be Valuable in the future. (DOI: 10.3171/2008.4.17569)
  • Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    BMJ case reports 2009 2009年 [査読有り][通常論文]
  • Satoru Takeuchi, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Naoki Otani, Yoshikazu Yoshino, Hiroshi Yatsushige, Takashi Sugawara
    BRITISH JOURNAL OF NEUROSURGERY 23 5 543 - 544 2009年 [査読有り][通常論文]
     
    Aneurysms of lenticulostriate artery (LSA) have rarely been reported. We present an extremely rare case of bilateral aneurysm of LSA, which spontaneously disappeared. A 59-year-old man presented to us with a decreased level of consciousness. Twice repeated blood culture was negative. Computed tomography (CT) showed bilateral basal ganglia hemorrhage with intraventricular extension and acute hydrocephalus. We performed external ventricular drainage. Cerebral angiograms, on 3 days after the onset, disclosed two aneurysms on the left LSA and one aneurysm on the right LSA. Cerebral angiography after 9 weeks demonstrated complete disappearance of three aneurysms.
  • [Case of traumatic dural arteriovenous fistula presenting as an acute subdural hematoma and an intracerebral hematoma. A case report].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    No shinkei geka. Neurological surgery 36 10 907 - 910 2008年10月 [査読有り][通常論文]
  • [Transient lesion in the splenium of the corpus callosum caused by diffuse axonal injury].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    Brain and nerve = Shinkei kenkyu no shinpo 60 9 1078 - 1079 2008年09月 [査読有り][通常論文]
  • [Case of vertebral artery occlusion caused by transverse process fracture of C7].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    Brain and nerve = Shinkei kenkyu no shinpo 60 7 870 - 873 2008年07月 [査読有り][通常論文]
  • [Transcatheter arterial embolization in the treatment of facial injury].
    Takeuchi S, Homma M, Kato H, Inoue J, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    No shinkei geka. Neurological surgery 36 6 505 - 511 2008年06月 [査読有り][通常論文]
  • [Case of adult pneumococcal meningitis associated with multiple cerebral infarction].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H, Homma M, Murata K, Amenomori S
    Brain and nerve = Shinkei kenkyu no shinpo 60 6 676 - 677 2008年06月 [査読有り][通常論文]
  • [Isolated traumatic oculomotor nerve palsy caused by minor head trauma].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    Brain and nerve = Shinkei kenkyu no shinpo 60 5 555 - 558 2008年05月 [査読有り][通常論文]
  • [Operative case of eosinophilic granuloma of the skull with dural invasion].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    No shinkei geka. Neurological surgery 36 3 239 - 243 2008年03月 [査読有り][通常論文]
  • [Case of venous angioma with chronic encapsulated hematoma].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H, Sumiyoshi K, Aoyagi C
    No shinkei geka. Neurological surgery 36 3 245 - 249 2008年03月 [査読有り][通常論文]
  • [3D CT findings of biparietal thinning].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    Brain and nerve = Shinkei kenkyu no shinpo 60 3 296 - 297 2008年03月 [査読有り][通常論文]
  • Low incidence of cerebral vasospasm after aneurismal subarachnoid haemorrhage: a comparison between surgical repairs and endovascular coil occlusions.
    Yoshino Y, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yatsushige H, Sugawara T, Kitahashi A, Obikane Y, Aoyagi C
    Acta Neurochir Suppl 104 337 - 340 2008年 [査読無し][通常論文]
  • Naoki Otani, Yoshio Takasato, Hiroyuki Masaoka, Takanori Hayakawa, Yoshikazu Yoshino, Hiroshi Yatsushige, Hiroki Miyawaki, Kyoko Sumiyoshi, Aoyagi Chikashi, Satoru Takeuchi, Goh Suzuki
    CEREBROVASCULAR DISEASES 26 6 612 - 617 2008年 [査読有り][通常論文]
     
    Background: Patients with poor-grade aneurysmal subarachnoid hemorrhage (SAH) presenting with large intracerebral (ICH) or sylvian hematomas (SylH) have poor outcomes due to the mass effect of significant brain stem compression following mass effect. On the other hand, decompressive craniectomy (DC) can reduce morbidity and mortality in critically ill patients with massive ischemic infarction and severe head injury. However, the role of DC in SAH patients is not fully understood. We investigated the outcome of DC in poor-grade SAH presenting with large ICH or SylH. Methods: 110 consecutive patients with poor-grade SAH (Hunt & Kosnik (H&K) grades IV and V, and Fisher group 4) were admitted to our hospital between April 1, 1993, and July 30, 2004. We treated 57 of those who presented with large ICH or SylH using DC. We retrospectively reviewed medical charts, radiological findings, operative notes, and video records. Results: Among the 57 patients (mean age 57.8, male 29, female 28), 25 were classified as H&K grade IV and 32 as grade V. Ruptured aneurysms were located on the internal carotid artery in 11 and the middle cerebral artery in 46 patients. 50 of the aneurysms were small, 5 were medium, and 2 were large. Rerupture was preoperatively confirmed in 13 (22.8%). Hypothermia was applied to 17 (29.8%). The Glasgow Outcome Scale on discharge showed good recovery, moderate recovery, severe disability, vegetative state, and death in 8 (14.0%), 13 (22.8%), 16 (28.1%), 8 (14.0%), and 12 (21.1%), respectively. The outcomes of grade IV patients were favorable and poor in 14 (56.0%) and 10 (40.0%), respectively, and 1 (4.0%) died. Conclusion: Several experimental studies have also indicated that DC significantly improves outcome due to reduced intracranial pressure or increased perfusion pressure. Urgent DC for poor-grade SAH with space-occupying hematoma can lead to survival with good recovery in some patients. Copyright (C) 2008 S. Karger AG, Basel
  • Spontaneous intracranial hypotension associated with dural sinus thrombosis.
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    Neurologia medico-chirurgica 47 12 555 - 558 2007年12月 [査読有り][通常論文]
  • [Prevertebral hematoma and traumatic atlantooccipital dislocation with survival--case report].
    Takeuchi S, Kato H, Matsuzaki H, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    Brain and nerve = Shinkei kenkyu no shinpo 59 10 1211 - 1214 2007年10月 [査読有り][通常論文]
  • Joon K. Song, Yasunari Niimi, Yoshikazu Yoshino, Shinya Khoyama, Alejandro Berenstein
    NEURORADIOLOGY 49 3 231 - 235 2007年03月 [査読有り][通常論文]
     
    Introduction Controversy exists as to whether Matrix coils are an improvement over bare platinum coils in preventing aneurysm recanalization in endosaccularly coiled large aneurysms. We investigated Matrix coils in a dog model of a wide-necked large bifurcation aneurysm. Methods Six experimental aneurysms were created in dogs and these aneurysms were endosaccularly coiled with 100% Matrix coils. Angiographic and histopathological data were analyzed at 2 weeks and at 3 months. Results Average aneurysm dimensions were length 17.8 mm, width 8.3 mm, and neck 6.2 mm. Aneurysm coil filling ranged 24.1 - 41.8% by volume. At 14 days, three of six Matrix-treated aneurysms showed coil compaction and aneurysm recanalization. At 3 months, one additional Matrix-treated aneurysm showed delayed coil compaction and aneurysm recanalization. At 3 months, in three harvested aneurysms, the average measured neck neointima was 0.150 +/- 0.14 mm. However, in two of the three aneurysms harvested at 3 months, aneurysm recanalization had occurred with neointimal tissue not completely covering the aneurysm orifice. Thick connective fibrous intercoil tissue was observed. No immediate or delayed thrombus formation had occurred. Conclusion Based on limited data in an experimental bifurcation aneurysm in dogs, Matrix coils appear to induce a thicker aneurysm neck neointima tissue and intercoil granulation response but appear prone to coil compaction and aneurysm recanalization. Modifications to the Matrix coil are likely needed to improve angiographic results in large aneurysms.
  • [Transient focal lesion in the splenium of the corpus callosum caused by carbamazepine].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H
    Brain and nerve = Shinkei kenkyu no shinpo 59 3 286 - 287 2007年03月 [査読有り][通常論文]
  • [Case of gustatory disturbance caused by pontine infarction].
    Takeuchi S, Takasato Y, Masaoka H, Hayakawa T, Otani N, Yoshino Y, Yatsushige H, Sugawara T
    No to shinkei = Brain and nerve 58 11 1005 - 1007 2006年11月 [査読有り][通常論文]
  • Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells
    Yoshikazu Yoshino, Masaru Aoyagi, Masashi Tamaki, Lian Duan, Takashi Morimoto, Kikuo Ohno
    INTERNATIONAL JOURNAL OF ONCOLOGY 29 4 981 - 987 2006年10月 [査読有り][通常論文]
     
    Malignant gliomas are typically angiogenic and secrete high levels of VEGF. Hypoxia has been identified as an important regulator of VEGF. However, malignant gliomas express high levels of VEGF in both hypoxic perinecrotic and vital tumor areas. In this study, we examined intracellular signaling pathways involved in the secretion of VEGF in glioma cells under normoxic conditions. Human malignant glioma cell lines, T98G, U373MG, U87MG, and A172, and human fetal lung fibroblasts (HFL) were cultured both with and without IL-1 beta under normoxic conditions. VEGF, IL-1, IL-6 and TNF-alpha were measured with ELISA. VEGF mRNA levels were estimated by RT-PCR. Inhibitors of COX-2, MAPK, and phosphatidyl inositol 3-kinase (PI3-K), and blocking antibodies to TGF-beta II and TNF-alpha, or IL-1 receptor antagonist, were used to examine their effects on VEGF secretion. Phosphorylation of MAPK was examined by immunoblotting. The basal levels of VEGF secretion were significantly higher in U87MG, U373MG, and T98G, than HFL. IL-1 beta significantly stimulated VEGF secretion in these glioma cells. Inhibitors of p38 MAPK and/or JNK significantly suppressed VEGF secretion both in the presence and absence of IL-1 beta, while inhibitors of COX-2, ERK1/2, and PI3-K. did not. Constitutive phosphorylation of p38 MAPK and JNK was observed in these glioma cells. The levels of IL-1 beta in U87MG were significantly higher than in other glioma cell lines, and IL-1 receptor antagonist suppressed basal secretion of VEGF from U87MG. In conclusion, p38 MAPK and JNK pathways play an important role in VEGF secretion from malignant glioma cells under normoxic conditions, possibly contributing to VEGF-induced angiogenesis in malignant gliomas at vital tumor areas where there is no hypoxia.
  • Creation of four experimental aneurysms with different hemodynamics in one dog
    YS Shin, Y Niimi, Y Yoshino, JK Song, M Silane, A Berenstein
    AMERICAN JOURNAL OF NEURORADIOLOGY 26 7 1764 - 1767 2005年08月 [査読有り][通常論文]
     
    We developed an experimental canine model in which four types of aneurysm-bifurcation, side-wall, small branch-artery, and arterial-stump-were surgically created in the same animal. These experimental aneurysms are exposed to simultaneous but different hemodynamic stresses correlating to human intracranial aneurysms in different locations. Because this model allowed for the creation of four aneurysms, each with different hemodynamic features, it seems to offer advantages from ones previously described. This model may foster investigation of new and current endovascular devices.
  • Preventing spontaneous thrombosis of experimental sidewall aneurysms: The oblique cut
    Y Yoshino, Y Niimi, JK Song, S Khoyama, YS Shin, A Berenstein
    AMERICAN JOURNAL OF NEURORADIOLOGY 26 6 1363 - 1365 2005年06月 [査読有り][通常論文]
     
    In our experience with the canine model, sidewall aneurysms made with an oblique-cut arteriotomy were less likely to thrombose than were those made with a standard technique.
  • Y Yoshino, Y Niimi, JK Song, M Silane, A Berenstein
    JOURNAL OF NEUROSURGERY 101 6 996 - 1003 2004年12月 [査読有り][通常論文]
     
    Object. The authors investigated whether HydroCoils decreased coil compaction and aneurysm recanalization in a canine model of a large, wide-necked, high-flow bifurcation aneurysm. Methods. Eleven experimental aneurysms were created. Two aneurysms were untreated (Group 1); three were treated with standard platinum coils (Guglielmi Detachable Coils; Group 2); and six were treated with platinum framing coils and filling HydroCoils (Group 3). Comparative angiographic and histopathological data were analyzed at 2 weeks and again at 3 months. At 3 months, the Group 1 aneurysms remained patent without spontaneous thrombosis. After coil placement the percentage of aneurysm filling by volume ranged from 59 to 90% (mean 75.4%) for Group 3 (HydroCoil-treated) and 34.3 to 48.9% (mean 39.6%) for Group 2 (GDC-treated) (p < 0.05). At 14 days, two of the three Group 2 aneurysms exhibited coil compaction and aneurysm recanalization at the neck; in both cases the condition worsened at 3 months. At 14 days and 3 months, five of the six Group 3 aneurysms were 100%, and one of six was 90% occluded and remained stable. At 3 months, the neointima of the aneurysm neck was significantly thicker in the Group 3 lesions, which had been treated by HydroCoils (0.329 +/- 0.191 mm), than in Group 2 lesions, which had been treated with GDCs (0.026 +/- 0.018 mm) (p < 0.001). No thrombus formation occurred in Group 2; however, in two of the six aneurysms in Group 3, thrombus formed at the coil-neck interface. Conclusions. The experimental canine bifurcation aneurysm model overcomes the limitations of side-wall aneurysm models. In this model, HydroCoils resulted in significantly denser coil packing, less follow-up coil compaction, and thicker neointimal tissue at the neck of the lesion. HydroCoils also appeared more thrombogenic at the aneurysm neck-parent artery interface.
  • Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisplatin and tumor necrosis factor alpha
    L Duan, M Aoyagi, M Tamaki, Y Yoshino, T Morimoto, H Wakimoto, Y Nagasaka, K Hirakawa, K Ohno, K Yamamoto
    CLINICAL CANCER RESEARCH 10 1 234 - 243 2004年01月 [査読有り][通常論文]
     
    Purpose: Tumor necrosis factor (TNF)-alpha elicits two opposing effects, the induction of apoptosis and the transcription of antiapoptotic genes. We have recently shown that cisplatin sensitizes glioma cells to TNF-induced apoptosis, but only in some cell lines. To understand the mechanism involved in the different susceptibilities, we examined both the activation of caspases and cytoprotective signaling by TNF-alpha. Experimental Design: Caspase activation was examined by estimating the cleavage of substrate peptides and by immunoblot to identify the cleavage of procaspases. Peptide inhibitors of caspases were used to reverse the cytotoxicity. The binding of TNF-alpha to the receptor was analyzed by flow cytometry. Nuclear factor (NF)-KB activation was assayed by the binding of NF-KB to oligonucleotides containing the consensus binding site. Interleukin (IL)-1beta, IL-6, IL-8, and manganous superoxide dismutase (MnSOD) were measured by enzyme-linked immunoassays. Results: T98G and U87MG underwent apoptosis on treatment with cisplatin and TNF-alpha, but U373MG and A172 were resistant. Caspases 2, 3, and 6-10, but not caspases 1, 4, and 5, were activated in sensitive cells, and none were activated in resistant cells. The binding of TNF-alpha to the receptor was the same in all four of the cell lines. In the sensitive cells, NF-KB activation and the production of IL-1beta, IL-6, IL-8, and MnSOD were significantly elevated by TNF-alpha. However, in the resistant cells, the production of IL-1beta and IL-6 were specifically impaired in response to TNF-alpha. Conclusions: Our results indicate that both apoptotic and cytoprotective pathways are impaired in glioma cells that are resistant to treatment with cisplatin and TNF-alpha.
  • Increased levels of tissue endostatin in human malignant gliomas.
    Morimoto T, Aoyagi M, Tamaki M, Yoshino Y, Hori H, Duan L, Yano T, Shibata M, Ohno K, Hirakawa K, Yamaguchi N
    Clinical cancer research : an official journal of the American Association for Cancer Research 8 9 2933 - 2938 2002年09月 [査読有り][通常論文]
  • Acute epidural hematoma developing during twist-drill craniostomy: A complication of percutaneous subdural tapping for the treatment of chronic subdural hematoma
    Y Yoshino, N Aoki, A Oikawa, K Ohno
    SURGICAL NEUROLOGY 53 6 601 - 604 2000年06月 [査読有り][通常論文]
     
    BACKGROUND This case illustrates that although percutaneous subdural tapping for patients with chronic subdural hematoma (CSDH) is successful and minimally invasive, it can be complicated by acute epidural hematoma. CASE PRESENTATION A 62-year-old woman presented with headache two months after minor head trauma. Computed tomography (CT) scanning revealed CSDH with mixed density on the right side. Prior to percutaneous subdural tapping, twist-drill craniostomy was performed at the parietal tuber. When the drill-needle reached the dura mater, the patient began to complain of headache, which was followed by altered consciousness. CT scanning disclosed acute epidural hematoma abutting the CSDH; both hematomas were evacuated by emergency craniotomy. At surgery, no definite bleeding source was identified apart from oozing on the dura mater. CONCLUSION Hemorrhagic complications after percutaneous subdural tapping are rare. The formation of acute epidural hematoma during twist-drill craniostomy has not been reported in the literature. This complication can occur when the blunt tip of the drill-needle remains on the dura mater without penetrating into the subdural hematoma cavity. (C) 2000 by Elsevier Science Inc.

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  • 巨大脳動脈瘤動物実験モデルの作成と治療法の開発
    文部科学省・日本学術振興会:科学研究費助成事業 基盤研究(C)
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    文部科学省・日本学術振興会:科学研究費助成事業 基盤研究(C)
    研究期間 : 2010年04月 -2012年03月 
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