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金田 るり カネダ ルリ

所属部署名博士課程人間生物学系専攻生体分子医学専攻分野抗加齢医学専攻科
職名准教授ホームページURL

プロフィール

研究キーワード

    心不全, ヒストン修飾酵素阻害薬, エピジェネティクス

研究分野

  • 内科系臨床医学 / 循環器内科学

学位

  • 医学博士

研究活動

論文

  • Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart.
    Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M
    Journal of molecular and cellular cardiology 82 116-124 2015年05月
  • MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures.
    Muraoka N, Yamakawa H, Miyamoto K, Sadahiro T, Umei T, Isomi M, Nakashima H, Akiyama M, Wada R, Inagawa K, Nishiyama T, Kaneda R, Fukuda T, Takeda S, Tohyama S, Hashimoto H, Kawamura Y, Goshima N, Aeba R, Yamagishi H, Fukuda K, Ieda M
    The EMBO journal 33(14) 1565-1581 2014年07月
  • Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells.
    Liu Y, Kaneda R, Leja TW, Subkhankulova T, Tolmachov O, Minchiotti G, Schwartz RJ, Barahona M, Schneider MD
    Stem cells (Dayton, Ohio) 32(6) 1515-1526 2014年06月
  • Induction of human cardiomyocyte-like cells from fibroblasts by defined factors.
    Wada R, Muraoka N, Inagawa K, Yamakawa H, Miyamoto K, Sadahiro T, Umei T, Kaneda R, Suzuki T, Kamiya K, Tohyama S, Yuasa S, Kokaji K, Aeba R, Yozu R, Yamagishi H, Kitamura T, Fukuda K, Ieda M
    Proceedings of the National Academy of Sciences of the United States of America 110(31) 12667-12672 2013年07月
  • Distinct iPS Cells Show Different Cardiac Differentiation Efficiency.
    Ohno Y, Yuasa S, Egashira T, Seki T, Hashimoto H, Tohyama S, Saito Y, Kunitomi A, Shimoji K, Onizuka T, Kageyama T, Yae K, Tanaka T, Kaneda R, Hattori F, Murata M, Kimura K, Fukuda K
    Stem cells international 2013 659739 2013年
  • Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5.
    Inagawa K, Miyamoto K, Yamakawa H, Muraoka N, Sadahiro T, Umei T, Wada R, Katsumata Y, Kaneda R, Nakade K, Kurihara C, Obata Y, Miyake K, Fukuda K, Ieda M
    Circulation research 111(9) 1147-1156 2012年10月
  • miR-142-3p is essential for hematopoiesis and affects cardiac cell fate in zebrafish.
    Nishiyama T, Kaneda R, Ono T, Tohyama S, Hashimoto H, Endo J, Tsuruta H, Yuasa S, Ieda M, Makino S, Fukuda K
    Biochemical and biophysical research communications 425(4) 755-761 2012年09月
  • G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation.
    Hara M, Yuasa S, Shimoji K, Onizuka T, Hayashiji N, Ohno Y, Arai T, Hattori F, Kaneda R, Kimura K, Makino S, Sano M, Fukuda K
    The Journal of experimental medicine 208(4) 715-727 2011年04月
  • Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction.
    Tamura Y, Matsumura K, Sano M, Tabata H, Kimura K, Ieda M, Arai T, Ohno Y, Kanazawa H, Yuasa S, Kaneda R, Makino S, Nakajima K, Okano H, Fukuda K
    Arteriosclerosis, thrombosis, and vascular biology 31(3) 582-589 2011年03月
  • 4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway.
    Zhang Y, Sano M, Shinmura K, Tamaki K, Katsumata Y, Matsuhashi T, Morizane S, Ito H, Hishiki T, Endo J, Zhou H, Yuasa S, Kaneda R, Suematsu M, Fukuda K
    Journal of molecular and cellular cardiology 49(4) 576-586 2010年10月
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  • Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart.
    Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M
    Journal of molecular and cellular cardiology 82 116-124 2015年05月
  • MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures.
    Muraoka N, Yamakawa H, Miyamoto K, Sadahiro T, Umei T, Isomi M, Nakashima H, Akiyama M, Wada R, Inagawa K, Nishiyama T, Kaneda R, Fukuda T, Takeda S, Tohyama S, Hashimoto H, Kawamura Y, Goshima N, Aeba R, Yamagishi H, Fukuda K, Ieda M
    The EMBO journal 33(14) 1565-1581 2014年07月
  • Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells.
    Liu Y, Kaneda R, Leja TW, Subkhankulova T, Tolmachov O, Minchiotti G, Schwartz RJ, Barahona M, Schneider MD
    Stem cells (Dayton, Ohio) 32(6) 1515-1526 2014年06月
  • Induction of human cardiomyocyte-like cells from fibroblasts by defined factors.
    Wada R, Muraoka N, Inagawa K, Yamakawa H, Miyamoto K, Sadahiro T, Umei T, Kaneda R, Suzuki T, Kamiya K, Tohyama S, Yuasa S, Kokaji K, Aeba R, Yozu R, Yamagishi H, Kitamura T, Fukuda K, Ieda M
    Proceedings of the National Academy of Sciences of the United States of America 110(31) 12667-12672 2013年07月
  • Distinct iPS Cells Show Different Cardiac Differentiation Efficiency.
    Ohno Y, Yuasa S, Egashira T, Seki T, Hashimoto H, Tohyama S, Saito Y, Kunitomi A, Shimoji K, Onizuka T, Kageyama T, Yae K, Tanaka T, Kaneda R, Hattori F, Murata M, Kimura K, Fukuda K
    Stem cells international 2013 659739 2013年
  • Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5.
    Inagawa K, Miyamoto K, Yamakawa H, Muraoka N, Sadahiro T, Umei T, Wada R, Katsumata Y, Kaneda R, Nakade K, Kurihara C, Obata Y, Miyake K, Fukuda K, Ieda M
    Circulation research 111(9) 1147-1156 2012年10月
  • miR-142-3p is essential for hematopoiesis and affects cardiac cell fate in zebrafish.
    Nishiyama T, Kaneda R, Ono T, Tohyama S, Hashimoto H, Endo J, Tsuruta H, Yuasa S, Ieda M, Makino S, Fukuda K
    Biochemical and biophysical research communications 425(4) 755-761 2012年09月
  • G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation.
    Hara M, Yuasa S, Shimoji K, Onizuka T, Hayashiji N, Ohno Y, Arai T, Hattori F, Kaneda R, Kimura K, Makino S, Sano M, Fukuda K
    The Journal of experimental medicine 208(4) 715-727 2011年04月
  • Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction.
    Tamura Y, Matsumura K, Sano M, Tabata H, Kimura K, Ieda M, Arai T, Ohno Y, Kanazawa H, Yuasa S, Kaneda R, Makino S, Nakajima K, Okano H, Fukuda K
    Arteriosclerosis, thrombosis, and vascular biology 31(3) 582-589 2011年03月
  • 4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway.
    Zhang Y, Sano M, Shinmura K, Tamaki K, Katsumata Y, Matsuhashi T, Morizane S, Ito H, Hishiki T, Endo J, Zhou H, Yuasa S, Kaneda R, Suematsu M, Fukuda K
    Journal of molecular and cellular cardiology 49(4) 576-586 2010年10月
  • Zac1 is an essential transcription factor for cardiac morphogenesis.
    Yuasa S, Onizuka T, Shimoji K, Ohno Y, Kageyama T, Yoon SH, Egashira T, Seki T, Hashimoto H, Nishiyama T, Kaneda R, Murata M, Hattori F, Makino S, Sano M, Ogawa S, Prall OW, Harvey RP, Fukuda K
    Circulation research 106(6) 1083-1091 2010年04月
  • Nongenetic method for purifying stem cell-derived cardiomyocytes.
    Hattori F, Chen H, Yamashita H, Tohyama S, Satoh YS, Yuasa S, Li W, Yamakawa H, Tanaka T, Onitsuka T, Shimoji K, Ohno Y, Egashira T, Kaneda R, Murata M, Hidaka K, Morisaki T, Sasaki E, Suzuki T, Sano M, Makino S, Oikawa S, Fukuda K
    Nature methods 7(1) 61-66 2010年01月
  • Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries.
    Wada T, Yamashita Y, Saga Y, Takahashi K, Koinuma K, Choi YL, Kaneda R, Fujiwara S, Soda M, Watanabe H, Kurashina K, Hatanaka H, Enomoto M, Takada S, Mano H, Suzuki M
    International journal of oncology 35(5) 973-976 2009年11月
  • MicroRNA is a new diagnostic and therapeutic target for cardiovascular disease and regenerative medicine.
    Kaneda R, Fukuda K
    Circulation journal : official journal of the Japanese Circulation Society 73(8) 1397-1398 2009年08月
  • Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis.
    Tokudome S, Sano M, Shinmura K, Matsuhashi T, Morizane S, Moriyama H, Tamaki K, Hayashida K, Nakanishi H, Yoshikawa N, Shimizu N, Endo J, Katayama T, Murata M, Yuasa S, Kaneda R, Tomita K, Eguchi N, Urade Y, Asano K, Utsunomiya Y, Suzuki T, Taguchi R, Tanaka H, Fukuda K
    The Journal of clinical investigation 119(6) 1477-1488 2009年06月
  • Genome-wide histone methylation profile for heart failure.
    Kaneda R, Takada S, Yamashita Y, Choi YL, Nonaka-Sarukawa M, Soda M, Misawa Y, Isomura T, Shimada K, Mano H
    Genes to cells : devoted to molecular & cellular mechanisms 14(1) 69-77 2009年01月
  • Identification of a constitutively active mutant of JAK3 by retroviral expression screening.
    Choi YL, Kaneda R, Wada T, Fujiwara S, Soda M, Watanabe H, Kurashina K, Hatanaka H, Enomoto M, Takada S, Yamashita Y, Mano H
    Leukemia research 31(2) 203-209 2007年02月
  • Evidence for activation of Amh gene expression by steroidogenic factor 1.
    Takada S, Wada T, Kaneda R, Choi YL, Yamashita Y, Mano H
    Mechanisms of development 123(6) 472-480 2006年06月
  • Nucleotide sequence and embryonic expression of quail and duck Sox9 genes.
    Takada S, Ota J, Kansaku N, Yamashita H, Izumi T, Ishikawa M, Wada T, Kaneda R, Choi YL, Koinuma K, Fujiwara S, Aoki H, Kisanuki H, Yamashita Y, Mano H
    General and comparative endocrinology 145(2) 208-213 2006年01月
  • Screening for genomic fragments that are methylated specifically in colorectal carcinoma with a methylated MLH1 promoter.
    Koinuma K, Kaneda R, Toyota M, Yamashita Y, Takada S, Choi YL, Wada T, Okada M, Konishi F, Nagai H, Mano H
    Carcinogenesis 26(12) 2078-2085 2005年12月
  • Transforming activity of the lymphotoxin-beta receptor revealed by expression screening.
    Fujiwara S, Yamashita Y, Choi YL, Wada T, Kaneda R, Takada S, Maruyama Y, Ozawa K, Mano H
    Biochemical and biophysical research communications 338(2) 1256-1262 2005年12月
  • Morning blood pressure hyper-reactivity is an independent predictor for hypertensive cardiac hypertrophy in a community-dwelling population.
    Kaneda R, Kario K, Hoshide S, Umeda Y, Hoshide Y, Shimada K
    American journal of hypertension 18(12 Pt 1) 1528-1533 2005年12月
  • Collagen metabolism in extracellular matrix may be involved in arterial stiffness in older hypertensive patients with left ventricular hypertrophy.
    Ishikawa J, Kario K, Matsui Y, Shibasaki S, Morinari M, Kaneda R, Hoshide S, Eguchi K, Hojo Y, Shimada K
    Hypertension research : official journal of the Japanese Society of Hypertension 28(12) 995-1001 2005年12月
  • Loss of diurnal rhythms of blood pressure and heart rate due to high fat feeding.
    Kaneda R, Kario K
    American journal of hypertension 18(10) 1327-1328 2005年10月
  • Retroviral expression screening of oncogenes in pancreatic ductal carcinoma.
    Kisanuki H, Choi YL, Wada T, Moriuchi R, Fujiwara S, Kaneda R, Koinuma K, Ishikawa M, Takada S, Yamashita Y, Mano H
    European journal of cancer (Oxford, England : 1990) 41(14) 2170-2175 2005年09月
  • Retroviral expression screening of oncogenes in natural killer cell leukemia.
    Choi YL, Moriuchi R, Osawa M, Iwama A, Makishima H, Wada T, Kisanuki H, Kaneda R, Ota J, Koinuma K, Ishikawa M, Takada S, Yamashita Y, Oshimi K, Mano H
    Leukemia research 29(8) 943-949 2005年08月
  • Genome-wide screening for target regions of histone deacetylases in cardiomyocytes.
    Kaneda R, Ueno S, Yamashita Y, Choi YL, Koinuma K, Takada S, Wada T, Shimada K, Mano H
    Circulation research 97(3) 210-218 2005年08月
  • Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells.
    Ishikawa M, Yoshida K, Yamashita Y, Ota J, Takada S, Kisanuki H, Koinuma K, Choi YL, Kaneda R, Iwao T, Tamada K, Sugano K, Mano H
    Cancer science 96(7) 387-393 2005年07月
  • Determinants of exaggerated difference in morning and evening blood pressure measured by self-measured blood pressure monitoring in medicated hypertensive patients: Jichi Morning Hypertension Research (J-MORE) Study.
    Ishikawa J, Kario K, Hoshide S, Eguchi K, Morinari M, Kaneda R, Umeda Y, Ishikawa S, Kuroda T, Hojo Y, Shimada K, J-MORE Study Group
    American journal of hypertension 18(7) 958-965 2005年07月
  • High-throughput screening of genome fragments bound to differentially acetylated histones.
    Kaneda R, Toyota M, Yamashita Y, Koinuma K, Choi YL, Ota J, Kisanuki H, Ishikawa M, Takada S, Shimada K, Mano H
    Genes to cells : devoted to molecular & cellular mechanisms 9(12) 1167-1174 2004年12月
  • DNA microarray analysis of dysplastic morphology associated with acute myeloid leukemia.
    Tsutsumi C, Ueda M, Miyazaki Y, Yamashita Y, Choi YL, Ota J, Kaneda R, Koinuma K, Fujiwara S, Kisanuki H, Ishikawa M, Ozawa K, Tomonaga M, Mano H
    Experimental hematology 32(9) 828-835 2004年09月


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