森 墾 (モリ ハルシ)

  • 放射線医学講座 教授
メールアドレス: hmori-tkyumin.ac.jp
Last Updated :2021/11/24



  • 博士(医学)(東京大学)


J-Global ID


  • 放射線科学   Radiology   


  • ライフサイエンス / 放射線科学


  • 2021年 - 現在  自治医科大学病院長補佐
  • 2020年 - 現在  自治医科大学教授
  • 2017年 - 2020年  東京大学准教授
  • 2009年 - 2017年  東京大学講師
  • 2000年 - 2009年  東京大学助手/助教


  • 日本アイソトープ協会   北米放射線学会   日本脳神経血管内治療学会   日本神経放射線学会   日本核磁気共鳴学会   日本医学放射線学会   RSNA   



  • Toshiyuki Itai, Satoko Miyatake, Taku Hatano, Nobutaka Hattori, Atsuko Ohno, Yusuke Aoki, Kazuya Itomi, Harushi Mori, Hirotomo Saitsu, Naomichi Matsumoto
    Human Genome Variation 8 1 20 - 20 2021年12月 [査読有り]
    AbstractWe describe two patients with NSD1 deletion, who presented with early-onset, or recurrent cerebrovascular diseases (CVDs). A 39-year-old female showed developmental delay and abnormal gait in infancy, and developed slowly-progressive intellectual disability and movement disorders. Brain imaging suggested recurrent parenchymal hemorrhages. A 6-year-old male had tremor as a neonate and brain imaging revealed subdural hematoma and brain contusion. This report suggests possible involvement of CVDs associated with NSD1 deletion.
  • Pin Fee Chong, Hiroyuki Torisu, Sawa Yasumoto, Akihisa Okumura, Harushi Mori, Tatsuharu Sato, Jun Kimura, Shouichi Ohga, Keiko Tanaka-Taya, Ryutaro Kira
    Clinical Neurophysiology 132 10 2456 - 2463 2021年10月 [査読有り]
  • Wataru Ueno, Naoto Sato, Kouichi Miura, Naoki Morimoto, Shunji Watanabe, Hiroaki Nomoto, Norio Isoda, Shigeyoshi Kijima, Tomohiro Kikuchi, Saki Manaka, Harushi Mori, Hironori Yamamoto
    Clinical Journal of Gastroenterology 2021年05月 [査読有り]
  • Shinichi Cho, Ryo Kurokawa, Akifumi Hagiwara, Wataru Gonoi, Harushi Mori, Takuya Kawahara, Moto Nakaya, Naoya Sakamoto, Nana Fujita, Satoru Kamio, Hiroaki Koyama, Osamu Abe
    Neuroradiology 2021年05月 [査読有り]
  • Pin Fee Chong, Ryutaro Kira, Hiroyuki Torisu, Sawa Yasumoto, Akihisa Okumura, Harushi Mori, Keiko Tanaka-Taya, Tatsuharu Sato, Akane Kanazawa, Keiko Suzuki, Etsushi Toyofuku, Tetsuhiro Fukuyama, Mari Asaoka, Takako Fujita, Tamami Yano, Akira Kumakura, Takayoshi Kawabata, Chiharu Miyatake, Masato Hiyane, Nobuko Moriyama, Naohisa Kawamura, Kenichi Tanaka, Genrei Ohta, Sahoko Ono, Kyoko Ban, Nobuyoshi Sugiyama, Kazuhide Ohta, Mika Inoue, Kenichi Sakajiri, Miho Yamamuro, Yusaku Endo, Kotaro Nakano, Noboru Yoshida, Yasuhiro Suzuki, Yuichi Takami, Mariko Kasai, Yuya Takahashi, Tomoyuki Miyamoto, Yu Ishida, Eri Takeshita, Yuichi Abe, Sonoko Kubota, Wakako Ishii, Yu Tsuyusaki, Ayako Hattori, Michiaki Nagura, Nozomi Koran, Taira Toki, Shinichiro Goto, Hiroshi Terashima, Eriko Kikuchi, Hitoshi Mikami, Yukihiko Konishi
    Pediatric Neurology 116 14 - 19 2021年03月 [査読有り]
    BACKGROUND: We summarize the long-term motor outcome and disability level in a cluster of pediatric patients with acute flaccid myelitis (AFM) associated with the enterovirus D68 outbreak in 2015. METHODS: This is a nationwide follow-up questionnaire analysis study. Clinical data including the motor function (manual muscle strength test) and other neurological symptoms were collected at the acute (nadir), recovery (six months), and chronic (three years) stages. We use the Barthel index, which measures 10 variables describing activity of daily living and mobility to assess the disability level. RESULTS: Clinical data of 33 patients with AFM (13 females, 20 males; median age = 4.1 years) were available. Among patients with tetraplegia or triplegia, paraplegia, and monoplegia at the acute stage, two of seven, four of thirteen, and two of thirteen exhibited complete recovery without paralysis; of those five of seven, eight of thirteen, and two of thirteen showed improvement with lesser limb involvement at the chronic stage, respectively. Nine patients (27%) demonstrated improvement at the recovery-to-chronic period. All six patients with positive isolation of enterovirus D68 from biological samples at the acute stage showed persistent motor deficits. Other neurological findings had better prognosis than motor weakness. Better Barthel index score at the chronic stage was observed (P < 0.001; median difference [95% confidence interval], 53 [40 to 63]), implying an improved disability level even in patients with persistent motor deficits. CONCLUSIONS: AFM has a high rate of persistent motor deficits showing one- to two-limb paralysis. Disability level of patients with AFM, however, generally improved at the three-year time point.
  • A Mitsutake, Y Nagashima, H Mori, H Sawamura, T Toda
    QJM: An International Journal of Medicine 2021年02月 [査読有り]
  • Kenichi Maeda, Pin Fee Chong, Satoshi Akamine, Fumiya Yamashita, Yuya Morooka, Harushi Mori, Sooyoung Lee, Yumi Mizuno, Ryutaro Kira
    Frontiers in pediatrics 9 732110 - 732110 2021年 
    Introduction: Kawasaki disease (KD) is an acute systemic vasculitis in children, but 0.4% of patients with KD exhibit central nervous system involvement. Acute encephalitis and encephalopathy accompanied with KD have been reported to be mostly self-limiting complications. Case Presentation: A 2-year-old girl developed recurrent vomiting, a cluster of generalized seizures, and decreased consciousness on day 12 after the onset of KD. Magnetic resonance imaging (MRI) T2-weighted images on day 13 showed high signal intensities in bilaterally symmetrical and subcortical white matter and thalamus, and linear radial hyperintensities parallel to the cerebral vessels of the periventricular white matter. Diffuse white matter hyperintensity on the apparent diffusion coefficient map suggested vasogenic edema. Subsequently, lethal cerebral edema rapidly progressed in 8 hrs after the MRI examination. Conclusion: To our knowledge, acute fulminant cerebral edema in patients with KD has not been previously reported. We should be aware of the possibility of severe encephalitis related to KD. Furthermore, diffuse white matter vasogenic edema with perivascular abnormalities on MRI may be an alerm, potentially leading to fatal cerebral edema.
  • Takehiko Inui, Moriei Shibuya, Takuya Miyabayashi, Ryo Sato, Yukimune Okubo, Wakaba Endo, Noriko Togashi, Yoshihisa Shimanuki, Harushi Mori, Kazuhiro Haginoya
    Brain and Development 43 1 170 - 173 2021年01月 [査読有り]
  • Masaki Katsura, Jiro Sato, Masaaki Akahane, Toshihiro Furuta, Harushi Mori, Osamu Abe
    RadioGraphics 41 1 224 - 248 2021年01月 [査読有り]
  • Takehiko Inui, Yoshihisa Shimanuki, Harushi Mori, Kazuhiro Haginoya
    Brain and Development 43 1 175 - 175 2021年01月 [査読有り][通常論文]
  • 扁桃体が肥大したてんかん患者の脳磁図分析(Magnetoencephalogram analysis of epilepsy patients with amygdala enlargement)
    Takegami Naoki, Kodama Satoshi, Shirota Yuichiro, Tamura Takayuki, Sakuishi Kaori, Kunii Naoto, Mori Harushi, Yumoto Masato, Hamada Masashi, Toda Tatsushi
    臨床神経学 60 Suppl. S298 - S298 2020年11月
  • Hiroyuki Fujii, Wakiro Sato, Yukio Kimura, Hiroshi Matsuda, Miho Ota, Norihide Maikusa, Fumio Suzuki, Keiko Amano, Isu Shin, Takashi Yamamura, Harushi Mori, Noriko Sato
    Journal of Neuroimaging 30 6 822 - 827 2020年11月 [査読有り][通常論文]
    BACKGROUND AND PURPOSE: Recent studies suggest that the autoantibodies against adrenergic/muscarinic receptors might be one of the causes and potential markers of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The purpose of this study was to investigate the structural network changes related to autoantibody titers against adrenergic/muscarinic receptors in ME/CFS by performing a single-subject gray matter similarity-based structural network analysis. METHODS: We prospectively examined 89 consecutive right-handed ME/CFS patients who underwent both brain MRI including 3D T1-wighted images and a blood analysis of autoantibodies titers against β1 adrenergic receptor (β1 AdR-Ab), β2 AdR-Ab, M3 acetylcholine receptor (M3 AchR-Ab), and M4 AchR-Ab. Single-subject gray matter similarity-based structural networks were extracted from segmented gray matter images for each patient. We calculated local network properties (betweenness centrality, clustering coefficient, and characteristic path length) and global network properties (normalized path length λ, normalized clustering coefficient γ, and small-world network value δ). We investigated the correlations between the autoantibody titers and regional gray matter/white matter volumes, the local network properties, and the global network properties. RESULTS: Betweenness centrality showed a significant positive correlation with β1-AdR-Ab in the right dorsolateral prefrontal cortex. The characteristic path length showed a significant negative correlation with β2-AdR-Ab in the right precentral gyrus. There were no significant correlations between the antibody titers and the regional gray matter/white matter volumes, and the global network properties. CONCLUSIONS: Our findings suggest that β1 AdR-Ab and β2 AdR-Ab are potential markers of ME/CFS.
  • Hiroya Nishida, Satoko Kumada, Takashi Komori, Keisuke Takai, Harushi Mori, Michiharu Morino, Hiromi Suzuki, Hideaki Mashimo, Kenji Inoue, Atsuko Arisaka, Mitsumasa Fukuda, Yasuhiro Nakata
    Brain and Development 42 9 675 - 679 2020年10月 [査読有り][通常論文]
  • Yukiko Usui, Ryo Kurokawa, Eriko Maeda, Harushi Mori, Shiori Amemiya, Jiro Sato, Kenji Ino, Rumiko Torigoe, Osamu Abe
    PLOS ONE 15 9 e0239459 - e0239459 2020年09月 [査読有り]
    This study aimed to evaluate the visualization of peripheral bronchioles in normal lungs via quarter-detector computed tomography (QDCT). Visualization of bronchioles within 10 mm from the pleura is considered a sign of bronchiectasis. However, it is not known peripheral bronchioles how close to the pleura in normal lungs can be tracked using QDCT. This study included 228 parts in 76 lungs from 38 consecutive patients who underwent QDCT. Reconstruction was performed with different thicknesses, increments, and matrix sizes: 0.5-mm thickness and increment with 512 and 1024 matrixes (Group5 and Group10, respectively) and 0.25-mm thickness and increment with 1024 matrix (Group10Thin). The distance between the most peripheral bronchiole visible and the pleura was determined in the three groups. The distance between the peripheral bronchial duct ends and the nearest pleural surface were significantly shorter in the order of Group10Thin, Group10, and Group5, and the mean distances from the pleura in Group10Thin and Group10 were shorter than 10 mm. These findings suggest the visualization of peripheral bronchioles in QDCT was better with a 1024 axial matrix than with a 512 matrix, and with a 0.25-mm slice thickness/increment than with a 0.5-mm slice thickness/increment. Our study also indicates bronchioles within 10 mm of the pleura do not necessarily indicate pathology.
  • R Kurokawa, Y Ota, W Gonoi, A Hagiwara, M Kurokawa, H Mori, E Maeda, S Amemiya, Y Usui, N Sato, Y Nakata, T Moritani, O Abe
    AJNR. American journal of neuroradiology 41 9 1683 - 1689 2020年08月 [査読有り][通常論文]
    BACKGROUND AND PURPOSE: Hypophysitis is one of the well-known adverse effects of immune checkpoint inhibitors. Immune checkpoint inhibitor-induced hypophysitis frequently causes irreversible hypopituitarism, which requires long-term hormone replacement. Despite the high frequency and clinical significance, characteristic MR imaging findings of immune checkpoint inhibitor-induced hypophysitis have not been established. In the present study, we aimed to review and extract the MR imaging features of immune checkpoint inhibitor-induced hypophysitis. MATERIALS AND METHODS: This retrospective international multicenter study comprised 20 patients with melanoma who were being treated with immune checkpoint inhibitors and clinically diagnosed with immune checkpoint inhibitor-induced hypophysitis. Three radiologists evaluated the following MR imaging findings: enlargement of the pituitary gland and stalk; homogeneity of enhancement of the pituitary gland; presence/absence of a well-defined poorly enhanced area and, if present, its location, shape, and signal intensity in T2WI; and enhancement pattern in contrast-enhanced dynamic MR imaging. Clinical symptoms and hormone levels were also recorded. RESULTS: Enlargement of the pituitary gland and stalk was observed in 12 and 20 patients, respectively. Nineteen patients showed poorly enhanced lesions (geographic hypoenhancing lesions) in the anterior lobe, and 11 of these lesions showed hypointensity on T2WI. Thyrotropin deficiency and corticotropin deficiency were observed in 19/20 and 12/17 patients, respectively, which persisted in 12/19 and 10/12 patients, respectively, throughout the study period. CONCLUSIONS: Pituitary geographic hypoenhancing lesions in the anterior lobe of the pituitary gland are characteristic and frequent MR imaging findings of immune checkpoint inhibitor-induced hypophysitis. They reflect fibrosis and are useful in distinguishing immune checkpoint inhibitor-induced hypophysitis from other types of hypophysitis/tumors.
  • Ryo Kurokawa, Wataru Gonoi, Hajime Yokota, Saiko Isshiki, Kenji Ohira, Hideaki Mizuno, Takao Kiguchi, Shohei Inui, Mariko Kurokawa, Shimpei Kato, Mitsuru Matsuki, Taro Takeda, Kota Yokoyama, Yoshiaki Ota, Yudai Nakai, Eriko Maeda, Harushi Mori, Osamu Abe
    European radiology 30 10 5588 - 5598 2020年05月 [査読有り][通常論文]
    OBJECTIVES: To compare CT findings of early (within 3 weeks post-onset)- and later (within 1 month before or after diagnostic criteria were satisfied, and later than 3 weeks post-onset) stage thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome. METHODS: Between 2014 and 2019, 13 patients with TAFRO syndrome (8 men and 5 women; mean age, 54.9 years) from nine hospitals were enrolled. The number of the following CT findings (CT factors) was recorded: the presence of anasarca, organomegaly, adrenal ischaemia, anterior mediastinal lesion, bony lesion, and lymphadenopathy. Records of adrenal disorders (adrenomegaly, ischaemia, and haemorrhage) throughout the disease course were also collected. Differences in CT factors at each stage were statistically compared between remission and deceased groups. RESULTS: Para-aortic oedema and mild lymphadenopathy were observed in all patients, whereas pleural effusion, ascites, and subcutaneous oedema were found in 5/13, 7/13, and 7/13 cases, respectively, at the early stage. CT factors at the early stage were significantly higher in the deceased than in the remission group (mean, 11 vs 6.5; p = 0.04), while they were nonsignificant at the later stage. Adrenal disorders were present in 7/13 cases throughout the course including 6 of adrenomegaly and 4 of ischaemia at the early stage. CONCLUSIONS: Para-aortic oedema and mild lymphadenopathy are most common at the early stage. Anasarca, organomegaly, lymphadenopathy, and adrenal disorders on early-stage CT are useful for unfavourable prognosis prediction. Moreover, adrenal disorders are frequent even at the early stage and are useful for early diagnosis of TAFRO syndrome. KEY POINTS: • CT findings facilitate early diagnosis and prognosis prediction in TAFRO syndrome. • Adrenal disorders are frequently observed in TAFRO syndrome. • Adrenal disorders are useful for differential diagnosis of TAFRO syndrome.
  • Ryusuke Irie, Shiori Amemiya, Tsuyoshi Ueyama, Yuichi Suzuki, Kouhei Kamiya, Hidemasa Takao, Harushi Mori, Osamu Abe
    Neuroradiology 62 10 1345 - 1349 2020年05月 [査読有り][通常論文]
    This pilot study tests the feasibility of rapid carotid MR angiography using the liver acquisition with volume acceleration-flex technique (LAVA MRA). Seven healthy volunteers and 21 consecutive patients suspected of carotid stenosis underwent LAVA and conventional time-of-flight (cTOF) MRAs. Artery-to-fat and artery-to-muscle signal intensity ratios were manually measured. LAVA MRA exhibited a significantly larger artery-to-fat signal intensity ratio compared with cTOF MRA in all slices (P < 0.001) and exhibited a larger (P < 0.001) or equivalent (P = 1.0) artery-to-muscle signal intensity ratio in the extracranial carotid arteries. The image quality of the cervical carotid bifurcation and the signal change on each MRA were visually assessed and compared among the MRAs. There was no significant difference between the two MRAs in visual assessment. LAVA MRA can provide visualization similar to cTOF MRA in the evaluation of the cervical carotid bifurcation while reducing scan time by one-fifth.
  • Chong PF, Yoshida T, Yuasa S, Mori H, Tanaka-Taya K, Kira R
    Pediatric Neurology 2020年04月 [査読有り][通常論文]
  • Kanako Danno, Mitsunaga Narushima, Takuya Iida, Chihena Banda, Takeshi Todokoro, Kensuke Tashiro, Ryohei Ishiura, Kohei Mitsui, Shine Tone, Harushi Mori
    Plastic and Reconstructive Surgery - Global Open 8 3 e2725 - e2725 2020年03月 [査読有り][通常論文]
    Genital arteriovenous malformations are rare and present unique surgical challenges in preserving urogenital function, abdominal wall integrity, and lower limb perfusion. A 32-year-old man with a giant abdominoscrotal arteriovenous malformation presented with recurrent heavy bleeding. Due to the high risk of rebleeding and fatal hemorrhage, surgery with curative intent was proposed and the patient was counseled on the risks of ischemia to the lower limb, testes, and penis. Preoperative embolization of the feeding vessels was performed. Three days later, surgical excision of the mass with the affected scrotum, left rectus muscle, sheath, and overlying abdominal skin followed. The testes were dissected from the malformation and preserved along with the right internal pudendal artery. The left thigh skin was advanced to the scrotal remnants and a neoscrotum created. The resulting large abdominal wall defect was reconstructed in layers with a pedicled anterolateral thigh flap, including innervated vastus lateralis muscle, to prevent herniation. Recovery was uneventful, and a 4-year follow-up revealed no significant clinical or radiological recurrence with recovery of flap sensation, retained erectile function, and no herniation. We report this case due to rarity of giant abdominoscrotal arteriovenous malformations and present preoperative embolization, surgical resection, and functional anterolateral thigh flap reconstruction as a valuable treatment option of this life-threatening illness.
  • 頸椎黄色靱帯内血腫の2例
    沖元 斉正, 中井 雄大, 中尾 貴祐, 田島 拓, 森 墾, 阿部 修, 中嶋 香児, 大島 寧
    Japanese Journal of Radiology 38 Suppl. 16 - 16 (公社)日本医学放射線学会 2020年02月
  • Takashi Matsukawa, Tomotaka Yamamoto, Akira Honda, Takashi Toya, Hiroyuki Ishiura, Jun Mitsui, Masaki Tanaka, Akihito Hao, Akihito Shinohara, Mizuki Ogura, Keisuke Kataoka, Sachiko Seo, Keiki Kumano, Masataka Hosoi, Kensuke Narukawa, Megumi Yasunaga, Hiroaki Maki, Motoshi Ichikawa, Yasuhito Nannya, Yoichi Imai, Tsuyoshi Takahashi, Yuji Takahashi, Yuki Nagasako, Kyoko Yasaka, Kagari Koshi Mano, Miho Kawabe Matsukawa, Toji Miyagawa, Masashi Hamada, Kaori Sakuishi, Toshihiro Hayashi, Atsushi Iwata, Yasuo Terao, Jun Shimizu, Jun Goto, Harushi Mori, Akira Kunimatsu, Shigeki Aoki, Shin Hayashi, Fumihiko Nakamura, Syunya Arai, Kazunari Momma, Katsuhisa Ogata, Toshikazu Yoshida, Osamu Abe, Johji Inazawa, Tatsushi Toda, Mineo Kurokawa, Shoji Tsuji
    Brain Communications 2 1 fcz048  2020年01月 [査読有り]
    Abstract Accumulated experience supports the efficacy of allogenic haematopoietic stem cell transplantation in arresting the progression of childhood-onset cerebral form of adrenoleukodystrophy in early stages. For adulthood-onset cerebral form of adrenoleukodystrophy, however, there have been only a few reports on haematopoietic stem cell transplantation and the clinical efficacy and safety of that for adulthood-onset cerebral form of adrenoleukodystrophy remain to be established. To evaluate the clinical efficacy and safety of haematopoietic stem cell transplantation, we conducted haematopoietic stem cell transplantation on 12 patients with adolescent-/adult-onset cerebral form/cerebello-brainstem form of adrenoleukodystrophy in a single-institution-based prospective study. Through careful prospective follow-up of 45 male adrenoleukodystrophy patients, we aimed to enrol patients with adolescent-/adult-onset cerebral form/cerebello-brainstem form of adrenoleukodystrophy at early stages. Indications for haematopoietic stem cell transplantation included cerebral form of adrenoleukodystrophy or cerebello-brainstem form of adrenoleukodystrophy with Loes scores up to 13, the presence of progressively enlarging white matter lesions and/or lesions with gadolinium enhancement on brain MRI. Clinical outcomes of haematopoietic stem cell transplantation were evaluated by the survival rate as well as by serial evaluation of clinical rating scale scores and neurological and MRI findings. Clinical courses of eight patients who did not undergo haematopoietic stem cell transplantation were also evaluated for comparison of the survival rate. All the patients who underwent haematopoietic stem cell transplantation survived to date with a median follow-up period of 28.6 months (4.2–125.3 months) without fatality. Neurological findings attributable to cerebral/cerebellar/brainstem lesions became stable or partially improved in all the patients. Gadolinium-enhanced brain lesions disappeared or became obscure within 3.5 months and the white matter lesions of MRI became stable or small. The median Loes scores before haematopoietic stem cell transplantation and at the last follow-up visit were 6.0 and 5.25, respectively. Of the eight patients who did not undergo haematopoietic stem cell transplantation, six patients died 69.1 months (median period; range 16.0–104.1 months) after the onset of the cerebral/cerebellar/brainstem lesions, confirming that the survival probability was significantly higher in patients with haematopoietic stem cell transplantation compared with that in patients without haematopoietic stem cell transplantation (P = 0.0089). The present study showed that haematopoietic stem cell transplantation was conducted safely and arrested the inflammatory demyelination in all the patients with adolescent-/adult-onset cerebral form/cerebello-brainstem form of adrenoleukodystrophy when haematopoietic stem cell transplantation was conducted in the early stages. Further studies are warranted to optimize the procedures of haematopoietic stem cell transplantation for adolescent-/adult-onset cerebral form/cerebello-brainstem form of adrenoleukodystrophy.
  • Ryo Kurokawa, Yudai Nakai, Wataru Gonoi, Harushi Mori, Tetsushi Tsuruga, Naohiro Makise, Tetsuo Ushiku, Osamu Abe
    European journal of radiology 124 108823 - 108823 2020年01月 [査読有り][通常論文]
    PURPOSE: The purpose of this retrospective study was to evaluate the usefulness of serum tumour markers and morphological characteristics in CT/MRI to differentiate between ovarian metastases from colorectal carcinomas (OMCRC) and primary ovarian carcinomas (POC). METHOD: Preoperative radiological images of 41 OMCRCs from 27 patients (mean age ± SD: 52.2 ± 10.7 years) and 46 POCs from 36 patients (52.1 ± 12.7 years) were included. Three blinded gynecological radiologists classified tumour morphology into 'mille-feuille sign', 'solid and cystic', 'multicystic without nodules', and 'multicystic with nodules' groups and analysed using Fisher's exact test. Serum carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), and carbohydrate antigen 19-9 levels were compared by Wilcoxon rank-sum test. RESULTS: 'Mille-feuille sign' indicated OMCRC (OMCRC: 8/41, POC: 1/46, specificity = 0.98, p = 0.011) and had excellent interobserver agreement (Fleiss's kappa value = 0.96). 'Solid and cystic' indicated POC (18/41 vs 41/45, p < 0.001) and 'multicystic without nodules' indicated OMCRC (8/41 vs 2/46, p = 0.041). There was no significant difference in 'multicystic with nodules'. CA125 levels were higher in POCs (292.5 U/mL vs. 41.0 U/mL, p = 0.003). CEA levels were higher in OMCRCs (24.5 ng/mL vs 2 ng/mL, p < 0.001). CEA (< 6.3 ng/mL) AND (CA125 (≥87.0 U/mL) OR 'solid and cystic') indicated POC with high accuracy (3/41 vs 44/46, accuracy = 0.94, p < 0.001). CONCLUSIONS: Our new method with morphological classification and tumour markers were useful for differentiating the two tumours. In particular, the 'mille-feuille sign' frequently indicated OMCRC with high specificity and excellent interobserver agreement.
  • Association of volume of self-directed versus assigned interpretive work with diagnostic performance of radiologists: an observational study.
    Amemiya Shiori, Mori Harushi, Takao Hidemasa, Abe Osamu.
    BMJ Open 9 12 2019年12月 [査読有り][通常論文]
  • Naohiro Tachibana, Takeshi Oichi, So Kato, Yusuke Sato, Hiroyuki Hasebe, Shima Hirai, Yuki Taniguchi, Yoshitaka Matsubayashi, Harushi Mori, Sakae Tanaka, Yasushi Oshima
    BMC musculoskeletal disorders 20 1 284 - 284 2019年06月 [査読有り][通常論文]
    BACKGROUND: Intramedullary hyperintense lesions associated with spinal cord edema on T2-weighted MR images (T2WI) are rare findings in patients with cervical spondylosis and are poorly characterized. We investigated the clinical characteristics of spinal cord edema due to cervical spondylosis (SCECS). METHODS: In total, 214 patients with cervical spondylotic myelopathy who underwent surgery between April 2007 and March 2017 were divided into SCECS and non-SCECS groups with SCECS defined as follows: (1) intramedullary signal intensity (ISI) of the cervical spinal cord in sagittal T2WI extending to more than one vertebral body height; (2) "fuzzy" ISI, recognized as a faint intramedullary change with a largely indistinct and hazy border; and (3) a larger sagittal diameter of the spinal cord segment with ISI just above or below the cord compression area compared with areas of the cervical spine without ISI. Radiographic parameters, demographic characteristics, and the Japanese Orthopedic Association (JOA) surgical outcomes score were compared between the groups. RESULTS: Seventeen patients (7.9%) were diagnosed with SCECS. These patients were younger than those in the non-SCECS group [median (interquartile range), 64 (20) vs. 69 (15) years, respectively, p = 0.016], and the disease duration from onset to surgery was significantly shorter in the SCECS group than in the non-SCECS group [6 (7) vs. 20 (48) months, respectively]. No significant difference was observed between groups with respect to sex, radiologic findings, or surgical outcomes. CONCLUSION: The disease showed an earlier onset and more rapid progression in the patients with SCECS than in those without SCECS.
  • Akihisa Okumura, Harushi Mori, Pin Fee Chong, Ryutaro Kira, Hiroyuki Torisu, Sawa Yasumoto, Hiroyuki Shimizu, Tsuguto Fujimoto, Keiko Tanaka-Taya
    Brain & development 41 5 443 - 451 2019年05月 [査読有り][通常論文]
    OBJECIVE: To clarify the neuroimaging findings of children with acute flaccid myelitis during an outbreak of EV-D68 infection. METHODS: We performed a detailed review of the spinal and cranial MRI results of 54 children with acute flaccid myelitis. We focused on the range of longitudinal lesions, the localization and appearance of lesions within a horizontal section, Gadolinium-enhancement, and changes over time. RESULTS: All children had longitudinal spinal lesions involving central gray matter. Twenty-six children had lesions spanning the entire spine. Six of them had weakness in all limbs, whereas seven had weakness of only one limb. Thirty-eight children had lesions in both gray and white matter and limb weakness tended to be more severe in these children. During the acute period, spinal lesions showed bilateral ill-defined widespread T2 hyperintensity. During the subacute period, lesions were well defined and confined to the anterior horn. The distribution of limb weakness was correlated with the appearance of lesions during the subacute period. Gadolinium enhancement was performed in 37 children, and enhancement was seen in the cauda equina in 29 children. Enhancement was infrequent within 2 days after onset but was seen in almost all children thereafter. Twenty-two children had brainstem lesions continuous with spinal lesions. CONCLUSION: Extensive longitudinal spinal lesions were characteristic in children with acute flaccid myelitis. Lesions were usually bilateral and widespread during the acute period, whereas localization to the anterior horn could become obvious. Although enhancement of the cauda equina was often observed, its appearance was sometimes delayed.
  • Akihisa Okumura, Harushi Mori
    Brain and Development 41 482  2019年05月 [査読有り][通常論文]
  • Ryo Kurokawa, Eriko Maeda, Harushi Mori, Shiori Amemiya, Jiro Sato, Kenji Ino, Rumiko Torigoe, Osamu Abe
    Medicine 98 19 e15538  2019年05月 [査読有り][通常論文]
    To compare coronary artery luminal enhancement in coronary computed tomography angiography (CCTA) between ventral and dorsal region-of-interest (ROI) bolus tracking in the descending aorta.The records of 165 consecutive patients who underwent CCTA with non-helical acquisition from July 2017 to March 2018 were retrospectively examined. We performed 320-row CCTA with bolus tracking [scan triggered at 260 HU in the descending aorta] and 133 patients were finally included. ROI was set in the ventral and dorsal halves of the descending aorta in 68 and 65 patients, respectively.Contrast arrival time was significantly shorter in the dorsal group (ventral: 21.8 ± 0.372 s; dorsal: 20.7 ± 0.369; P = .0295). The mean density of the proximal and distal RCA was significantly higher in the ventral group (proximal: ventral, 428.1 ± 6.95 HU; dorsal, 405.5 ± 7.72 HU, P = .0318; distal: ventral, 418.0 ± 9.29 HU; dorsal, 393.2 ± 9.46 HU, P = .0133).Dorsal bolus tracking ROI in the descending thoracic aorta significantly reduced preparation time and RCA CT values.
  • 「急性弛緩性麻痺の新たな動向」 急性弛緩性麻痺(AFP)サーベイランス
    多屋 馨子, 吉良 龍太郎, チョン・ピンフィー, 鳥巣 浩幸, 安元 佐和, 細矢 光亮, 八代 将登, 奥村 彰久, 森 墾, 清水 博之, 新橋 玲子, 新井 智, 花岡 希, 藤本 嗣人
    NEUROINFECTION 24 1 58 - 66 日本神経感染症学会 2019年04月 
  • Ryoji Miyano, Masanori Kurihara, Kenta Orimo, Tatsuo Mano, Toshikatsu Kaburaki, Rie Tanaka, Hironobu Nishijima, Masako Ikemura, Miwako Takahashi, Harushi Mori, Tatsuro Mutoh, Masashi Hamada, Toshihiro Hayashi, Tatsushi Toda
    A 71-year-old woman with a 6-month history of relapsing bilateral anterior scleritis presented with severe right visual impairment due to posterior scleritis. Despite radiological signs of encephalitis, the patient and her family members noticed no cognitive decline. The patient subsequently developed slight auricular pain without any visual changes such as redness or swelling, which, however, showed increased uptake of F-18-fluorodeoxyglucose on positron emission tomography. Auricular cartilage biopsy revealed perichondrial inflammation suggesting relapsing polychondritis. Steroid therapy improved her symptoms and radiological findings. This case illustrates that asymptomatic brain inflammatory lesions can precede clinical signs of chondritis in relapsing polychondritis, and that auricular cartilage biopsy should be considered even with mild auricular pain without apparent clinical findings of inflammation.
  • Akihisa Okumura, Harushi Mori
    Developmental Medicine and Child Neurology 61 290 - 291 2019年03月 [査読有り][通常論文]
  • Akira Kunimatsu, Natsuko Kunimatsu, Koichiro Yasaka, Hiroyuki Akai, Kouhei Kamiya, Takeyuki Watadani, Harushi Mori, Osamu Abe
    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 18 1 44 - 52 2019年01月 [査読有り][通常論文]
    PURPOSE: Although advanced MRI techniques are increasingly available, imaging differentiation between glioblastoma and primary central nervous system lymphoma (PCNSL) is sometimes confusing. We aimed to evaluate the performance of image classification by support vector machine, a method of traditional machine learning, using texture features computed from contrast-enhanced T1-weighted images. METHODS: This retrospective study on preoperative brain tumor MRI included 76 consecutives, initially treated patients with glioblastoma (n = 55) or PCNSL (n = 21) from one institution, consisting of independent training group (n = 60: 44 glioblastomas and 16 PCNSLs) and test group (n = 16: 11 glioblastomas and 5 PCNSLs) sequentially separated by time periods. A total set of 67 texture features was computed on routine contrast-enhanced T1-weighted images of the training group, and the top four most discriminating features were selected as input variables to train support vector machine classifiers. These features were then evaluated on the test group with subsequent image classification. RESULTS: The area under the receiver operating characteristic curves on the training data was calculated at 0.99 (95% confidence interval [CI]: 0.96-1.00) for the classifier with a Gaussian kernel and 0.87 (95% CI: 0.77-0.95) for the classifier with a linear kernel. On the test data, both of the classifiers showed prediction accuracy of 75% (12/16) of the test images. CONCLUSIONS: Although further improvement is needed, our preliminary results suggest that machine learning-based image classification may provide complementary diagnostic information on routine brain MRI.
  • Satoshi Kodama, Yuichiro Shirota, Akifumi Hagiwara, Juuri Otsuka, Kazuya Sato, Yusuke Sugiyama, Harushi Mori, Masako Watanabe, Masashi Hamada, Tatsushi Toda
    Clinical neurophysiology practice 4 164 - 167 2019年 [査読有り][通常論文]
    Introduction: Multinodular and vacuolating neuronal tumor (MVNT) had been initially described as an epilepsy-related brain tumor, but recent studies demonstrated it could be found incidentally in non-epilepsy patients. Case report: A 33-year-old woman with intractable post-encephalitis epilepsy presented a cluster of multinodular T2 hyperintensity in the left temporal lobe, which was very similar to the characteristics of MVNT. Long-term video electroencephalogram demonstrated that the habitual seizures were originated from bilateral temporal area and the interictal epileptic discharges were seen multifocally, although the lesions with MVNT appearance were localized in the left temporal lobe. It was presumed that the epilepsy in this patient was due to encephalitis in the past, and the link between the lesions and the epilepsy in this patient seemed weak. Conclusion: Although MVNT had been considered as an epilepsy-related brain tumor, we suggest it is not necessarily preferable to perform surgical resection of MVNT even on patients with epilepsy, unless epileptic foci are highly related to MVNT.
  • Kazuki Hatayama, Shinichiro Goto, Masato Yashiro, Harushi Mori, Tsuguto Fujimoto, Nozomu Hanaoka, Keiko Tanaka-Taya, Tomoka Zuzan, Masaru Inoue
    IDCases 17 e00549  2019年01月 [査読有り][通常論文]
    © 2019 The Authors Acute flaccid myelitis (AFM)is a recently defined clinical disease accompanied by the national outbreak of enterovirus D68 (EV-D68)in the United States during the late summer/fall of 2014; 258 cases of EV-D68 and 59 cases of AFM were reported in Japan during the late summer/fall of 2015. Subsequently, there have been no epidemics of AFM or EV-D68. However, we encountered a patient who had AFM associated with EV-D68 in 2017. This is the first case of AFM caused by EV-D68 after the 2015 epidemic, and the only reported case in 2017. This report indicates that AFM caused by EV-D68 can arise even in non-epidemic situations. If a patient presents with paralysis, AFM caused by EV-D68 should be included in the differential diagnosis, regardless of the absence of an epidemic of EV-D68 infection.
  • Nanaka Yamaguchi, Tatsuo Mano, Ryo Ohtomo, Hiroyuki Ishiura, M Asem Almansour, Harushi Mori, Junko Kanda, Yuichiro Shirota, Kenichiro Taira, Teppei Morikawa, Masako Ikemura, Yasuo Yanagi, Shigeo Murayama, Jun Shimizu, Yasuhisa Sakurai, Shoji Tsuji, Atsushi Iwata
    Internal medicine (Tokyo, Japan) 57 23 3459 - 3462 2018年12月 [査読有り][通常論文]
    Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease with marked variety in its clinical manifestations. While characteristic neuroimaging and skin biopsy findings are important clues to the diagnosis, autopsy studies are still important for confirming the exact disease features. We herein report the case of a patient who received an antemortem diagnosis of familial NIID with dementia-dominant phenotype that was later confirmed by an autopsy. Our report is the first to document a case of autopsy-confirmed NIID involving both cognitive impairment and sensorimotor neuropathy.
  • Satoko Miyatake, Sacha Schneeberger, Norihisa Koyama, Kenji Yokochi, Kayo Ohmura, Masaaki Shiina, Harushi Mori, Eriko Koshimizu, Eri Imagawa, Yuri Uchiyama, Satomi Mitsuhashi, Martin C Frith, Atsushi Fujita, Mai Satoh, Masataka Taguri, Yasuko Tomono, Keita Takahashi, Hiroshi Doi, Hideyuki Takeuchi, Mitsuko Nakashima, Takeshi Mizuguchi, Atsushi Takata, Noriko Miyake, Hirotomo Saitsu, Fumiaki Tanaka, Kazuhiro Ogata, Thierry Hennet, Naomichi Matsumoto
    Annals of neurology 84 6 843 - 853 2018年12月 [査読有り][通常論文]
    OBJECTIVE: Approximately 5% of cerebral small vessel diseases are hereditary, which include COL4A1/COL4A2-related disorders. COL4A1/COL4A2 encode type IV collagen α1/2 chains in the basement membranes of cerebral vessels. COL4A1/COL4A2 mutations impair the secretion of collagen to the extracellular matrix, thereby resulting in vessel fragility. The diagnostic yield for COL4A1/COL4A2 variants is around 20 to 30%, suggesting other mutated genes might be associated with this disease. This study aimed to identify novel genes that cause COL4A1/COL4A2-related disorders. METHODS: Whole exome sequencing was performed in 2 families with suspected COL4A1/COL4A2-related disorders. We validated the role of COLGALT1 variants by constructing a 3-dimensional structural model, evaluating collagen β (1-O) galactosyltransferase 1 (ColGalT1) protein expression and ColGalT activity by Western blotting and collagen galactosyltransferase assays, and performing in vitro RNA interference and rescue experiments. RESULTS: Exome sequencing demonstrated biallelic variants in COLGALT1 encoding ColGalT1, which was involved in the post-translational modification of type IV collagen in 2 unrelated patients: c.452 T > G (p.Leu151Arg) and c.1096delG (p.Glu366Argfs*15) in Patient 1, and c.460G > C (p.Ala154Pro) and c.1129G > C (p.Gly377Arg) in Patient 2. Three-dimensional model analysis suggested that p.Leu151Arg and p.Ala154Pro destabilized protein folding, which impaired enzymatic activity. ColGalT1 protein expression and ColGalT activity in Patient 1 were undetectable. RNA interference studies demonstrated that reduced ColGalT1 altered COL4A1 secretion, and rescue experiments showed that mutant COLGALT1 insufficiently restored COL4A1 production in cells compared with wild type. INTERPRETATION: Biallelic COLGALT1 variants cause cerebral small vessel abnormalities through a common molecular pathogenesis with COL4A1/COL4A2-related disorders. Ann Neurol 2018;84:843-853.
  • Harushi Mori
    Brain and nerve = Shinkei kenkyu no shinpo 70 1349 - 1358 2018年12月 [査読有り][通常論文]
    Here, I review the efficacy of radiological methods in the diagnosis of diplopia/double vision. The simplest technique for achieving a successful diagnosis is to capture a wide field-of-view image. In order to start the process of diagnosis, it is fundamental to first study the image findings. Analysis based on the principle of MECE or mutually exclusive collectively exhaustive is performed using four methods: deductive reasoning, fractionation, longitudinal study, and priority setting. The conventional practical procedure to attain a diagnosis is as follows. First, identify the location of the lesion by imaging, which will shorten the list of differential diagnosis. Second, obtain as much information as possible on the characteristics of the lesion in order to determine the pathology. Third, look for any associated findings, such as tortuous vasculature around the brain. Fourth, refer to all the available information; for example, the main complaint, clinical history, previous history, family history, physical findings, physiological findings, laboratory data, previous images, and other modalities. Finally, if still in doubt, one should consult with colleagues and the attending physician. However, because rationality (statistical analyses, such as posterior probability or positive predictive value with positive findings), predicted utility, and emotions play a factor in a person's decision making, it seems impossible to completely avoid oversights and misdiagnosis.
  • Masaki Katsura, Jiro Sato, Masaaki Akahane, Taku Tajima, Toshihiro Furuta, Harushi Mori, Osamu Abe
    Neuroradiology 60 11 1141 - 1150 2018年11月 [査読有り][通常論文]
    © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: To evaluate the effects of the single-energy metal artifact reduction (SEMAR) algorithm on image quality of cerebral CT and CT angiography (CTA) for patients who underwent intracranial aneurysm coiling. Methods: Twenty patients underwent cerebral CT and CTA using a 320-detector row CT after intracranial aneurysm coiling. Images with and without application of the SEMAR algorithm (SEMAR CT and standard CT images, respectively) were reconstructed for each patient. The images were qualitatively assessed by two independent radiologists in a blinded manner for the depiction of anatomical structures around the coil, delineation of the arteries around the coil, and the depiction of the status of coiled aneurysms. Artifact strength was quantitatively assessed by measuring the standard deviation of attenuation values around the coil. Results: The strength of artifacts measured in SEMAR CT images was significantly lower than that in standard CT images (25.7 ± 10.2 H.U. vs. 80.4 ± 67.2 H.U., p < 0.01, Student’s paired t test). SEMAR CT images were significantly improved compared with standard CT images in the depiction of anatomical structures around the coil (p < 0.01, the sign test), delineation of the arteries around the coil (p < 0.01), and the depiction of the status of coiled aneurysms (p < 0.01). Conclusion: The SEMAR algorithm significantly reduces metal artifacts from intracranial aneurysm coiling and improves visualization of anatomical structures and arteries around the coil, and depiction of the status of coiled aneurysms on post-interventional cerebral CT.
  • Kouhei Kamiya, Naohiro Okada, Kingo Sawada, Yusuke Watanabe, Ryusuke Irie, Shouhei Hanaoka, Yuichi Suzuki, Shinsuke Koike, Harushi Mori, Akira Kunimatsu, Masaaki Hori, Shigeki Aoki, Kiyoto Kasai, Osamu Abe
    NMR in biomedicine 31 7 e3938  2018年07月 [査読有り][通常論文]
    Major depressive disorder (MDD) is a globally prevalent psychiatric disorder that results from disruption of multiple neural circuits involved in emotional regulation. Although previous studies using diffusion tensor imaging (DTI) found smaller values of fractional anisotropy (FA) in the white matter, predominantly in the frontal lobe, of patients with MDD, studies using diffusion kurtosis imaging (DKI) are scarce. Here, we used DKI whole-brain analysis with tract-based spatial statistics (TBSS) to investigate the brain microstructural abnormalities in MDD. Twenty-six patients with MDD and 42 age- and sex-matched control subjects were enrolled. To investigate the microstructural pathology underlying the observations in DKI, a compartment model analysis was conducted focusing on the corpus callosum. In TBSS, the patients with MDD showed significantly smaller values of FA in the genu and frontal portion of the body of the corpus callosum. The patients also had smaller values of mean kurtosis (MK) and radial kurtosis (RK), but MK and RK abnormalities were distributed more widely compared with FA, predominantly in the frontal lobe but also in the parietal, occipital, and temporal lobes. Within the callosum, the regions with smaller MK and RK were located more posteriorly than the region with smaller FA. Model analysis suggested significantly smaller values of intra-neurite signal fraction in the body of the callosum and greater fiber dispersion in the genu, which were compatible with the existing literature of white matter pathology in MDD. Our results show that DKI is capable of demonstrating microstructural alterations in the brains of patients with MDD that cannot be fully depicted by conventional DTI. Though the issues of model validation and parameter estimation still remain, it is suggested that diffusion MRI combined with a biophysical model is a promising approach for investigation of the pathophysiology of MDD.
  • Longitudinally extensive vasogenic edema following spinal cord infarction
    Takashi Gondo, Masanori Kurihara, Yusuke Sugiyama, Tatsuo Mano, Harushi Mori, Toshihiro Hayashi & Shoji Tsuji
    Neurology and Clinical Neuroscience/ 6 5 2018年06月 [査読有り][通常論文]
  • Tomoaki Nakada, Shu Kikuta, Harushi Mori, Yuya Shimizu, Hironobu Nishijima, Kenji Kondo, Tatsuya Yamasoba
    ORL 80 1 41 - 50 2018年05月 [査読有り][通常論文]
    Objectives: On computed tomography (CT), sinonasal schwannoma displays as a soft-tissue mass without any distinctive features. Our aim was to define the radiological criteria for distinguishing schwannoma from other sinonasal benign tumours. Methods: We retrospectively identified consecutive patients who were pathologically diagnosed with benign sinonasal tumours between 2007 and 2016. CT attenuation values were compared between benign tumours and the brainstem. The utilities of demographic factors, clinical factors, and CT parameters for predicting the CT attenuation values of the brainstem were analysed by univariate and multivariate regression. Results: Of the 111 identified cases of benign tumours, the CT attenuation values of tumours and the brainstem were analysed in 36 cases (schwannoma, 4 cases inverted papilloma, 26 juvenile nasopharyngeal angiofibroma, 3 cavernous haemangioma, 3). The CT attenuation values of the schwannomas were significantly lower than in the brainstem, while those of the other tumours were significantly higher than in the brainstem. No factors affected the CT attenuation values of the brainstem. Conclusion: Low CT attenuation values of sinonasal benign tumours relative to the brainstem could distinguish schwannomas from other benign tumours.
  • Pin Fee Chong, Ryutaro Kira, Harushi Mori, Akihisa Okumura, Hiroyuki Torisu, Sawa Yasumoto, Hiroyuki Shimizu, Tsuguto Fujimoto, Nozomu Hanaoka, Susumu Kusunoki, Toshiyuki Takahashi, Kazunori Oishi, Keiko Tanaka-Taya
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 66 5 653 - 664 2018年02月 [査読有り][通常論文]
    Background: Acute flaccid myelitis (AFM) is an acute flaccid paralysis syndrome with spinal motor neuron involvement of unknown etiology. We investigated the characteristics and prognostic factors of AFM clusters coincident with an enterovirus D68 (EV-D68) outbreak in Japan during autumn 2015. Methods: An AFM case series study was conducted following a nationwide survey from August to December 2015. Radiographic and neurophysiologic data were subjected to centralized review, and virology studies were conducted for available specimens. Results: Fifty-nine AFM cases (58 definite, 1 probable) were identified, including 55 children and 4 adults (median age, 4.4 years). The AFM epidemic curve showed strong temporal correlation with EV-D68 detection from pathogen surveillance, but not with other pathogens. EV-D68 was detected in 9 patients: 5 in nasopharyngeal, 2 in stool, 1 in cerebrospinal fluid (adult case), and 1 in tracheal aspiration, nasopharyngeal, and serum samples (a pediatric case with preceding steroid usage). Cases exhibited heterogeneous paralysis patterns from 1- to 4-limb involvement, but all definite cases had longitudinal spinal gray matter lesions on magnetic resonance imaging (median, 20 spinal segments). Cerebrospinal fluid pleocytosis was observed in 50 of 59 cases (85%), and 8 of 29 (28%) were positive for antiganglioside antibodies, as frequently observed in Guillain-Barré syndrome. Fifty-two patients showed variable residual weakness at follow-up. Good prognostic factors included a pretreatment manual muscle strength test unit score >3, normal F-wave persistence, and EV-D68-negative status. Conclusions: EV-D68 may be one of the causative agents for AFM, while host susceptibility factors such as immune response could contribute to AFM development.
  • Hayakawa YK, Sasaki H, Takao H, Yoshikawa T, Hayashi N, Mori H, Kunimatsu A, Aoki S, Ohtomo K
    Obesity science & practice 4 1 97 - 105 2018年02月 [査読有り][通常論文]
  • Akira Kunimatsu, Natsuko Kunimatsu, Kouhei Kamiya, Takeyuki Watadani, Harushi Mori, Osamu Abe
    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 17 1 50 - 57 2018年01月 [査読有り][通常論文]
    PURPOSE: To elucidate differences between glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL) with MR image-based texture features. METHODS: This was an Institutional Review Board (IRB)-approved retrospective study. Consecutive, pathologically proven, initially treated 44 patients with GBM and 16 patients with PCNSL were enrolled. We calculated a total of 67 image texture features on the largest contrast-enhancing lesion in each patient on post-contrast T1-weighted images. Texture analyses included first-order features (histogram) and second-order features calculated with gray level co-occurrence matrix, gray level run length matrix (GLRLM), gray level size zone matrix, and multiple gray level size zone matrix. All texture features were measured by two neuroradiologists independently and the intraclass correlation coefficients were calculated. Reproducible features with the intraclass correlation coefficients of greater than 0.7 were used for hierarchical clustering between the cases and the features along with unpaired t statistics-based comparisons under the control of false discovery rate (FDR) < 0.05. Principal component analysis (PCA) was performed to find the predominant features in evaluating the differences between GBM and PCNSL. RESULTS: Twenty-one out of the 67 features satisfied the acceptable intraclass correlation coefficient and the FDR constraints. PCA suggested first-order entropy, median, GLRLM-based run length non-uniformity, and run percentage as the distinguished features. Compared with PCNSL, run percentage and median were significantly lower, and entropy and run length non-uniformity were significantly higher in GBM. CONCLUSIONS: Among MR image-based textures, first-order entropy, median, GLRLM-based run length non-uniformity, and run percentage are considered to enhance differences between GBM and PCNSL.
  • Go Taniguchi, Hitomi Fuse, Yumiko Okamura, Harushi Mori, Shinsuke Kondo, Kiyoto Kasai, Yukitoshi Takahashi, Keiko Tanaka
    Epilepsy & behavior case reports 10 96 - 98 2018年 [査読有り][通常論文]
    Focal neuroinflammation is considered one of the hypotheses for the cause of temporal lobe epilepsy (TLE) with amygdala enlargement (AE). Here, we report a case involving an adult female patient with TLE-AE characterized by late-onset seizures and cognitive impairment. Anti-N-methyl-d-aspartate receptor (NMDAR) antibodies were detected in her cerebrospinal fluid. However, administration of appropriate anti-seizure drugs (ASD), without immunotherapy, improved TLE-AE associated with NMDAR antibodies. In the present case, two clinically significant observations were made: 1) anti-NMDAR antibody-mediated autoimmune processes may be associated with TLE-AE, and 2) appropriate administration of ASD alone can improve clinical symptoms in mild cases of autoimmune epilepsy.
  • Hiroshi Takumida, Mitsutaka Yakabe, Harushi Mori, Koji Shibasaki, Yumi Umeda-Kameyama, Tomohiko Urano, Tatsuo Mano, Akimasa Hayashi, Masako Ikemura, Sumito Ogawa, Masahiro Akishita
    GERIATRICS & GERONTOLOGY INTERNATIONAL 17 12 2623 - 2625 2017年12月 [査読無し][通常論文]
  • 骨Paget病と硬化性骨転移の鑑別にCTガイド下生検が有用であった3例
    佐藤 次郎, 渡邉 祐亮, 古田 寿宏, 安武 毅, 佐藤 祥恵, 川合 豪, 松田 出, 田島 拓, 佐藤 裕子, 岩佐 亮史, 黒川 遼, 赤松 展彦, 大倉 直樹, 森 墾, 阿部 修
    IVR: Interventional Radiology 32 Suppl. 370 - 370 (一社)日本インターベンショナルラジオロジー学会 2017年04月
  • Kouhei Kamiya, Masaaki Hori, Ryusuke Irie, Masakazu Miyajima, Madoka Nakajima, Koji Kamagata, Kouhei Tsuruta, Asami Saito, Misaki Nakazawa, Yuichi Suzuki, Harushi Mori, Akira Kunimatsu, Hajime Arai, Shigeki Aoki, Osamu Abe
    NEUROIMAGE-CLINICAL 14 663 - 671 2017年 [査読無し][通常論文]
    The symptoms of idiopathic normal pressure hydrocephalus (iNPH) can be improved by shunt surgery, but prediction of treatment outcome is not established. We investigated changes of the corticospinal tract (CST) in iNPH before and after shunt surgery by using diffusion microstructural imaging, which infers more specific tissue properties than conventional diffusion tensor imaging. Two biophysical models were used: neurite orientation dispersion and density imaging (NODDI) and white matter tract integrity (WMTI). In both methods, the orientational coherence within the CSTs was higher in patients than in controls, and some normalization occurred after the surgery in patients, indicating axon stretching and recovery. The estimated axon density was lower in patients than in controls but remained unchanged after the surgery, suggesting its potential as a marker for irreversible neuronal damage. In a Monte-Carlo simulation that represented model axons as undulating cylinders, both NODDI and WMTI separated the effects of axon density and undulation. Thus, diffusion MRI may distinguish between reversible and irreversible microstructural changes in iNPH. Our findings constitute a step towards a quantitative image biomarker that reflects pathological process and treatment outcomes of iNPH. (C) 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • Shun Okamura, Yuki Saito, Harushi Mori, Tatsuya Yamasoba
    BMJ Case Reports 2017 2017年 [査読無し][通常論文]
  • Hiroki Hongo, Satoru Miyawaki, Hideaki Imai, Yuki Shinya, Hideaki Ono, Harushi Mori, Hirofumi Nakatomi, Akira Kunimatsu, Nobuhito Saito
    Surgical neurology international 8 104 - 104 2017年 [査読無し][通常論文]
    BACKGROUND: Intracranial atherosclerosis (ICAS) involves diverse histologies and several remodeling patterns. Ring finger protein 213 (RNF213) c.14576G>A variant (rs112735431), recently reported to be associated with ICAS, may be linked with negative remodeling (outer diameter - reducing morphological alteration) of intracranial arteries. This study investigated the outer diameter of atherosclerotic middle cerebral artery (MCA). METHODS: Patients with unilateral atherosclerotic MCA stenosis/occlusion were enrolled in this single-hospital-based case-control study at The University of Tokyo Hospital. The patients were divided into two groups by the presence of RNF213 c.14576G>A (variant group and wild-type group) and the outer diameter of the MCA was measured with high-resolution magnetic resonance imaging. RESULTS: Twenty-eight patients with the wild type and 19 patients with the variant type were included. The outer diameter of the stenotic side MCA was smaller in the variant group than in the wild-type group (P = 8.3 × 10-6). The outer diameter of the normal side MCA was also smaller in the variant group than in the wild-type group (P = 5.2 × 10-3). The ratio of stenotic side to normal side was also smaller in the variant group than in the wild-type group (P = 1.5 × 10-5). CONCLUSIONS: This study indicates that RNF213 c.14576G>A is associated with negative remodeling of ICAS.
  • 入江隆介, 萩原彰文, 神谷昴平, 安達木綿子, 堀正明, 森墾, 青木茂樹, 國松総
    画像診断 36 13 1258 - 1269 2016年11月 [査読無し][招待有り]
  • Ken Matsubara, Harushi Mori, Nozomi Hirai, Kumi Yasukawa, Takafumi Honda, Jun-ichi Takanashi
    BRAIN & DEVELOPMENT 38 10 964 - 967 2016年11月 [査読無し][通常論文]
    MRI in a 2-year-old female presenting afebrile seizures and left blepharoptosis revealed multiple well-marginated round-shaped lesions, isointensity to gray matter on T1- and T2-weighted images with homogenously reduced diffusion and diffuse contrast enhancement. MRS revealed elevation of taurine, choline and glutamate, and reduction of N-acetylaspartate. A brain biopsy confirmed a diagnosis of juvenile xanthogranuloma (JXG). JXG should be considered when MR spectroscopy shows elevated taurine and glutamate, which has only previously been reported in medulloblastomas. (C) 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
  • Tokushige Shin-ichi, Terao Yasuo, Matsuda Shun-ichi, Inomata-Terada Satomi, Shimizu Takahiro, Tanaka Nobuyuki, Hamada Masashi, Yugeta Akihiro, Hanajima Ritsuko, Mori Harushi, Tsuji Shoji, Ugawa Yoshikazu
    NEUROLOGY AND CLINICAL NEUROSCIENCE 4 4 146 - 152 2016年07月 [査読有り][通常論文]
  • Kunimatsu, Akira, Kunimatsu, Natsuko, Kamiya, Kouhei, Katsura, Masaki, Mori, Harushi, Ohtomo, Kuni
    JAPANESE JOURNAL OF RADIOLOGY 34 7 459 - 469 2016年07月 [査読無し][通常論文]
    Meningiomas are common neoplasms that frequently occur in the brain and spine. Among the 15 histological subtypes of meningiomas in the WHO classification, the incidence of meningothelial meningiomas is the highest, followed by fibrous and transitional meningiomas. These three subtypes account for approximately 80 % of all meningiomas, and thus could be regarded as typical meningiomas. For this reason, other uncommon histological subtypes may be considered as imaging variants, and diagnosis is often challenging for radiologists solely based on imaging features of typical meningiomas. In addition to the histological subtypes, meningiomas arising in atypical locations could be easily mistaken for other lesions more commonly observed in those locations. The purpose of this article is to review characteristic clinical and imaging findings of uncommon meningiomas, including histological variants and meningiomas occurring in relatively rare locations.
  • Kouhei Kamiya, Shiori Amemiya, Yuichi Suzuki, Naoto Kunii, Kensuke Kawai, Harushi Mori, Akira Kunimatsu, Nobuhito Saito, Shigeki Aoki, Kuni Ohtomo
    MAGNETIC RESONANCE IN MEDICAL SCIENCES 15 1 121 - 129 2016年 [査読無し][通常論文]
    Background and Purpose: We analyzed the ability of a machine learning approach that uses diffusion tensor imaging (DTI) structural connectomes to determine lateralization of epileptogenicity in temporal lobe epilepsy (TLE). Materials and Methods: We analyzed diffusion tensor and 3-dimensional (3D) T-1-weighted images of 44 patients with TLE (right, 15, left, 29; mean age, 33.0 +/- 11.6 years) and 14 age-matched controls. We constructed a whole brain structural connectome for each subject, calculated graph theoretical network measures, and used a support vector machine (SVM) for classification among 3 groups (right TLE versus controls, left TLE versus controls, and right TLE versus left TLE) following a feature reduction process with sparse linear regression. Results: In left TLE, we found a significant decrease in local efficiency and the clustering coefficient in several brain regions, including the left posterior cingulate gyrus, left cuneus, and both hippocampi. In right TLE, the right hippocampus showed reduced nodal degree, clustering coefficient, and local efficiency. With use of the leave-one-out cross-validation strategy, the SVM classifier achieved accuracy of 75.9 to 89.7% for right TLE versus controls, 74.4 to 86.0% for left TLE versus controls, and 72.7 to 86.4% for left TLE versus right TLE. Conclusion: Machine learning of graph theoretical measures from the DTI structural connectome may give support to lateralization of the TLE focus. The present good discrimination between left and right TLE suggests that, with further refinement, the classifier should improve presurgical diagnostic confidence.
  • Kouhei Kamiya, Koji Kamagata, Masakazu Miyajima, Madoka Nakajima, Masaaki Hori, Kohei Tsuruta, Harushi Mori, Akira Kunimatsu, Hajime Arai, Shigeki Aoki, Kuni Ohtomo
    MAGNETIC RESONANCE IN MEDICAL SCIENCES 15 3 316 - 323 2016年 [査読無し][通常論文]
    Purpose: Diffusional kurtosis imaging (DKI) is an emerging technique that describes diffusion of water molecules in terms of deviation from Gaussian distribution. This study investigated correlations between DKI metrics and cognitive function in patients with idiopathic normal pressure hydrocephalus (iNPH). Materials and Methods: DKI was performed in 29 iNPH patients and 14 age-matched controls. Mini-mental state examination (MMSE), frontal assessment battery (FAB), and trail making test A (TMT-A) were used as cognitive measures. Tract-based spatial statistics (TBSS) analyses were performed to investigate the between-group differences and correlations with the cognitive measures of the diffusion metrics, including mean kurtosis (MK), fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusivity (AD), and radial diffusivity (RD). Results: In iNPH patients, FA and MK identified positive correlations with cognitive function in similar regions, predominantly in the frontal lobes (P < 0.05, corrected for multiple comparisons). The frontoparietal subcortical white matter showed significant correlations with FAB and TMT-A across more extensive areas in MK analyses than in FA. ADC, AD, and RD analyses showed no significant correlations with MMSE and FAB, while negative correlation with TMT-A was observed in the limited portion of the frontal deep white matter. Conclusion: Both FA and MK correlated well with cognitive impairment in iNPH. The observed differences between FA and MK results suggest DKI may play a complementary role to conventional FA and ADC analyses, especially for evaluation of the subcortical white matter.
  • Masanori Yoshino, Taichi Kin, Akihiro Ito, Toki Saito, Daichi Nakagawa, Kenji Ino, Kyousuke Kamada, Harushi Mori, Akira Kunimatsu, Hirofumi Nakatomi, Hiroshi Oyama, Nobuhito Saito
    JOURNAL OF NEUROSURGERY 123 6 1480 - 1488 2015年12月 [査読無し][通常論文]
    OBJECT The authors assessed whether the combined use of diffusion tensor tractography (DTT) and contrast-enhanced (CE) fast imaging employing steady-state acquisition (FIESTA) could improve the accuracy of predicting the courses of the facial and cochlear nerves before surgery. METHODS The population was composed of 22 patients with vestibular schwannoma in whom both the facial and cochlear nerves could be identified during surgery. According to DTT, depicted fibers running from the internal auditory canal to the brainstem were judged to represent the facial or vestibulocochlear nerve. With regard to imaging, the authors investigated multifused CE-FIESTA scans, in which all 3D vessel models were shown simultaneously, from various angles. The low-intensity areas running along the tumor from brainstem to the internal auditory canal were judged to represent the facial or vestibulocochlear nerve. RESULTS For all 22 patients, the rate of fibers depicted by DTT coinciding with the facial nerve was 13.6% (3/22), and that of fibers depicted by DTT coinciding with the cochlear nerve was 63.6% (14/22). The rate of candidates for nerves predicted by multifused CE-FIESTA coinciding with the facial nerve was 59.1% (13/22), and that of candidates for nerves predicted by multifused CE-FIESTA coinciding with the cochlear nerve was 4.5% (1/22). The rate of candidates for nerves predicted by combined DTT and multifused CE-FIESTA coinciding with the facial nerve was 63.6% (14/22), and that of candidates for nerves predicted by combined DTT and multifused CE-FIESTA coinciding with the cochlear nerve was 63.6% (14/22). The rate of candidates predicted by DTT coinciding with both facial and cochlear nerves was 0.0% (0/22), that of candidates predicted by multifused CE-FIESTA coinciding with both facial and cochlear nerves was 4.5% (1/22), and that of candidates predicted by combined DTT and multifused CE-FIESTA coinciding with both the facial and cochlear nerves was 45.5% (10/22). CONCLUSIONS By using a combination of DTT and multifused CE-FIESTA, the-authors were able to increase the number of vestibular schwannoma patients for whom predicted results corresponded with the courses of both the facial and cochlear nerves, a result-that has been considered difficult to achieve by use of a single modality only. Although the 3D image including these prediction results helped with comprehension of the 3D operative anatomy, the reliability of prediction remains to be established.
  • Takeshi Oichi, Hirotaka Chikuda, Teppei Morikawa, Harushi Mori, Daisuke Kitamura, Junya Higuchi, Yuki Taniguchi, Yoshitaka Matsubayashi, Yasushi Oshima, Sakae Tanaka
    JOURNAL OF NEUROSURGERY-SPINE 23 6 784 - 787 2015年12月 [査読無し][通常論文]
    Dumbbell-shaped tumors consisting of 2 different tumors are extremely rare. Herein, the authors present a case of concurrent spinal schwannoma and meningioma mimicking a single cervical dumbbell-shaped tumor. A 64-year-old man presented with a 5-year history of gradually exacerbating left occipital pain without clinical evidence of neurofibromatosis. Magnetic resonance imaging showed an extradural tumor along the left C-2 nerve root with a small intradural component. The tumor was approached via a C-1 hemilaminectomy. The intradural tumor was resected together with the extradural tumor after opening the dura meter. The intradural tumor was attached to the dura mater around the exit point of the C-2 nerve root. lntraoperative biopsy revealed that the extradural tumor was a schwannoma and that the intradural tumor was a meningioma. The dura mater adjacent to the tumor was then coagulated and resected. Postoperative pathological examination confirmed the same diagnoses with no evidence of continuity between the intra- and extradural components. The patient's postoperative clinical course was uneventful. Clinicians should be aware that cervical dumbbell-shaped tumors can consist of 2 different tumors.
  • Naoaki Fujisawa, Soichi Oya, Harushi Mori, Toru Matsui
    Journal of Korean Neurosurgical Society 58 5 487 - 490 2015年11月 [査読無し][通常論文]
    © 2015 The Korean Neurosurgical Society. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a relapsing-remitting disorder for which steroid administration is a key to control the progression. CLIPPERS can exhibit radiological features similar to malignant lymphoma, whose diagnosis is confounded by prior steroid administration. We report a case of CLIPPERS accompanied by abnormal elevation of β-2 microglobulin in the cerebrospinal fluid (CSF). A 62-year-old man started to experience numbness in all fingers of his left hand one year ago, which gradually extended to his body trunk and legs on both sides. Magnetic resonance imaging demonstrated numerous small enhancing spots scattered in his brain and spinal cord. CSF levels of β-2 microglobulin were elevated; although this often indicates central nervous system involvement in leukemia and lymphoma, the lesions were diagnosed as CLIPPERS based on the pathological findings from a biopsy specimen. We emphasize the importance of biopsy to differentiate between CLIPPERS and malignant lymphoma because the temporary radiological response to steroid might be the same in both diseases but the treatment strategies regarding the use of steroid are quite different.
  • Masanori Yoshino, Taichi Kin, Akihiro Ito, Toki Saito, Daichi Nakagawa, Kenji Ino, Kyousuke Kamada, Harushi Mori, Akira Kunimatsu, Hirofumi Nakatomi, Hiroshi Oyama, Nobuhito Saito
    ACTA NEUROCHIRURGICA 157 6 939 - 946 2015年06月 [査読無し][通常論文]
    According to recent findings, diffusion tensor tractography (DTT) only allows prediction of facial nerve location in relation to vestibular schwannoma (VS) with high probability. However, previous studies have not mentioned why only the facial nerve was selectively visualized. Our previous report investigated the optimal conditions of DTT for normal facial and vestibulocochlear nerves. In the present study, we applied the optimal conditions of DTT to VS patients to assess the feasibility of DTT for the facial and vestibulocochlear nerves. We investigated 11 patients with VS who underwent tumor resection. Visualized tracts were compared with locations of the facial and cochlear nerves as identified by intraoperative electrophysiological monitoring. With the proposed method, visualized tracts corresponded to pathway area of the facial or cochlear nerves in nine of 11 patients (81.8 %); specifically, to the pathway area of the facial nerve in three of 11 patients (27.3 %), and to the pathway area of the cochlear nerve in six of 11 patients (54.5 %). We visualized facial or vestibulocochlear nerves in nine of 11 patients (81.8 %). For the first time, DTT proved able to visualize not only the facial nerve but also the vestibulocochlear nerve in VS patients. Despite our findings, good methods for distinguishing whether a visualized nerve tract represents facial nerve, vestibulocochlear nerve, or only noise remain unavailable. Close attention should therefore be paid to the interpretation of visualized fibers.
  • Masanori Yoshino, Taichi Kin, Akihiro Ito, Toki Saito, Daichi Nakagawa, Kyousuke Kamada, Harushi Mori, Akira Kunimatsu, Hirofumi Nakatomi, Hiroshi Oyama, Nobuhito Saito
    Diffusion tensor tractography (DTT) is not adequately reliable for prediction of facial and vestibulocochlear (VII-VIII) nerve locations, especially relative to a vestibular schwannoma (VS). Furthermore, it is often not possible to visualize normal VII-VIII nerves by DTT (visualization rates were 12.5-63.6 %). Therefore, DTT post-processing was optimized for normal VII-VIII nerve visualization with and without manual noise elimination. DTT examinations of ten patients were evaluated to assess the improvement in performance by modifying seed region of interest (ROI) and fractional anisotropy (FA) threshold. Seed ROI was placed at the porus of the internal auditory meatus, and FA threshold values were either fixed or variable for each patient. DTT visualization of cranial nerves VII-VIII was evaluated and the noise effect was measured. Cranial nerves VII-VIII were visualized in 90 % of patients without using manual noise elimination by modifying the seed ROI and FA threshold. The visualization rate with FA threshold of the upper limit in each patient (100 %) was significantly higher than that with FA threshold of 0.1 (75 %) (). The incidence rate of noise with FA threshold of the upper limit (10 %) was not significantly different than the FA threshold of 0.1 (20 %) (). Seed ROI modification and FA thresholding can improve the visualization of cranial nerve VII-VIII locations in DTT. This technique is promising for its potential to determine the relationship of cranial nerves VII-VIII to VS.
  • Masami Goto, Osamu Abe, Shigeki Aoki, Naoto Hayashi, Hiroshi Ohtsu, Hidemasa Takao, Tosiaki Miyati, Hiroshi Matsuda, Fumio Yamashita, Takeshi Iwatsubo, Harushi Mori, Akira Kunimatsu, Kenji Ino, Keiichi Yano, Kuni Ohtomo
    Radiological Physics and Technology 8 1 64 - 72 2015年 [査読無し][通常論文]
    © 2014, Japanese Society of Radiological Technology and Japan Society of Medical Physics. Our aim was to show whether sensitivity for detecting volume changes in regional gray matter in default mode network (DMN) at converted [from mild cognitive impairment to Alzheimer’s disease (from MCI to AD)] phase was improved by use of a standardized volume with global gray-matter volume. T1-weighted MR images (T1WI) of seven normal subjects and seven converted (from MCI to AD) patients were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Gray-matter images segmented with Statistical Parametric Mapping 5 were measured by the atlas-based method. We focused on five nodes of the DMN. For each phase, region of interest (ROI) volumes in the five nodes were standardized by two methods: (1) the ratio to the screening phase (S_volume) and (2) the ratio to the screening phase after both volumes were standardized by the global gray-matter volume (S_N_volume). Significant group differences between longitudinal gray-matter volume change of the converted (from MCI to AD) group and that of the normal group were found in lateral temporal cortex by S_N_volume, and precuneus by S_N_volume. These findings are useful for improving the understanding of DMN volume changes at the converted (from MCI to AD) phase.
  • M. Goto, O. Abe, S. Aoki, N. Hayashi, T. Miyati, H. Takao, H. Matsuda, F. Yamashita, T. Iwatsubo, H. Mori, A. Kunimatsu, K. Ino, K. Yano, K. Ohtomo
    METHODS OF INFORMATION IN MEDICINE 54 2 171 - 178 2015年 [査読無し][通常論文]
    Objectives: To investigate whether reproducibility of gray matter volumetry is influenced by parameter settings for VBM 8 using Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) with region-of-interest (ROI) analyses. Methods: We prepared three-dimensional T1-weighted magnetic resonance images (3D-T1 WIs) of 21 healthy subjects. All subjects were imaged with each of five MRI systems. Voxel-based morphometry 8 (VBM 8) and WFU PickAtlas software were used for gray matter volumetry. The bilateral ROI labels used were those provided as default settings with the software: Frontal Lobe, Hippocampus, Occipital Lobe, Orbital Gyrus, Parietal Lobe, Putamen, and Temporal Lobe. All 3D-T1 Wls were segmented to gray matter with six parameters of VBM 8, with each parameter having between three and eight selectable levels. Reproducibility was evaluated as the standard deviation (mm(3)) of measured values for the five MRI systems. Results: Reproducibility was influenced by 'Bias regularization (BiasR)', 'Bias FWHM, and 'De-noising filter' settings, but not by 'MRF weighting', 'Sampling distance', or 'Warping regularization' settings. Reproducibility in BiasR was influenced by ROI. Superior reproducibility was observed in Frontal Lobe with the BiasR1 setting, and in Hippocampus, Parietal Lobe, and Putamen with the BiasR3*, BiasR1, and BiasR5 settings, respectively. Conclusion: Reproducibility of gray matter volumetry was influenced by parameter settings in VBM 8 using DARTEL and ROI. In multi-center studies, the use of appropriate settings in VBM 8 with DARTEL results in reduced scanner effect.
  • H. Mori, A. Kunimatsu, K. Ohtomo
    Japanese Journal of Clinical Radiology 60 741 - 748 2015年01月 [査読無し][通常論文]
    Magnetic resonance imaging findings of the central nervous system in ciliopathy-related disorders were described. The neuroimaging hallmarks of Joubert syndrome and related disorders (JSRD) include vermian hypoplasia and the molar-tooth sign (MTS). The MTS results from a midbrain-hindbrain malformation characterized by thickened and elongated superior cerebellar peduncles and an abnormally deep interpeduncular fossa. Bardet-Biedl syndrome shows little cerebellar malformations but a high rate of hippocampal dysgenesis which is consistent with cognitive impairment. Meckel-Gruber syndrome has not only the triad of occipital encephalocele, bilateral enlarged multicystic kidneys and postaxial Polydactyly, but also wide variety of other malformations. Orofaciodigital syndrome type VI (OFD VI) exhibit a more severe neuroimaging pattern than other JSRD, including brainstem and cerebellar abnormalities, gyration disorder, polymicrogy-ria and/or heterotopia. Leber congenital amaurosis can also show the similar findings of JSRD. When we look at the MTS, therefore, we must search for further complicating disorders of other organs and musculoskeletal system to make a precise diagnosis.
  • Yuki Shinya, Satoru Miyawaki, Hirofumi Nakatomi, Atsushi Okano, Hideaki Imai, Masahiro Shin, Kazuya Sato, Takeyuki Tsuchida, Toshihiro Hayashi, Yasuo Terao, Satoe Numakura, Teppei Morikawa, Junji Shibahara, Shu Kikuta, Kenji Kondo, Keita Tatsuno, Harushi Mori, Akira Kunimatsu, Shoji Tsuji, Nobuhito Saito
    Destructive infiltration of invasive fungal sinusitis can easily occur into the central nervous system (CNS). Cerebral aneurysms associated with fungal infection are highly vulnerable to rupture, and can frequently and rapidly take a serious clinical course. We experienced a patient who twice developed cerebral aneurysm followed by rupture due to invasive fugal sinusitis. This 77-year-old man was admitted for progressive bilateral visual disturbance, which was initially treated as idiopathic hypertrophic pachymeningitis. The patient subsequently suffered subarachnoid hemorrhage (SAH) twice in only 12 days. Both SAH originated from different newly formed cerebral aneurysms. Trapping was performed for both ruptured aneurysms. Pathological examination of the resected aneurysms indicated the presence of fungi determined to be Aspergillus. This Aspergillus infection was also discovered inside the frontal sinus by endoscopic biopsy, so a regimen of antifungal agents was instituted. Prolonged antifungal therapy caused renal impairment, which ultimately led to the patient's death. Autopsy detected no mycotic infiltration of the major cerebral arteries, except for the 2 ruptured cerebral aneurysms. However, prolonged mycosis of the CNS, such as in the deep part in the falx cerebri and in the small veins proximal to the tentorium cerebelli, was observed, indicating that mycosis invading the cranium is refractory even to long-term administration of antifungal agents. The present case strongly suggests that urgent and proactive definitive diagnosis is essential to successfully treat invasive paranasal sinus aspergillosis. If infiltration of the CNS is suspected, early surgical resection and antifungal therapy must be initiated immediately.
  • Tsukasa Tsuchiya, Soichi Oya, Harushi Mori, Toru Matsui
    Surgical Neurology International 6 1 2015年01月 [査読無し][通常論文]
    Background: Epithelioid hemangioendotheliomas (EHE) is an extremely rare tumor that can arise not only intracranially but also systemically. Its radiological characteristics and the mechanism underlying the multiple organ involvement in EHE are poorly understood. Case Description: A 24-year-old woman with a 7-month history of coughing and blood-stained sputum complained of visual disturbance in the right eye that had persisted for 1-month. Magnetic resonance (MR) imaging revealed multiple intraparenchymal masses with low-intensity on MR susceptibility-weighted images with minimal enhancement with gadolinium. Systemic computed tomography revealed multiple nodules in both lungs and the liver. Because her neurological status rapidly deteriorated, brain biopsy of the right frontal mass was performed. The pathological diagnosis was EHE. Over the following 3 months, the patient gradually developed disturbance of consciousness. She died at 4 months after admission because of significant intracranial hypertension. Conclusion: Although intracranial EHEs are extremely rare, they should be included in the differential diagnoses of multiple small-sized masses with low-intensity on MR susceptibility-weighted images. We also emphasize that the systemic involvement of this tumor was more compatible with multicentric development than metastasis.
  • Masami Goto, Akira Kunimatsu, Masaaki Shojima, Harushi Mori, Osamu Abe, Shigeki Aoki, Naoto Hayashi, Wataru Gonoi, Tosiaki Miyati, Kenji Ino, Keiichi Yano, Nobuhito Saito, Kuni Ohtomo
    CLINICAL NEUROLOGY AND NEUROSURGERY 126 177 - 184 2014年11月 [査読無し][通常論文]
    Background: To evaluate the sensitivity, specificity, and accuracy of time-of-flight MR angiography (MRA) compared with CT angiography (CTA) for detection of branch vessels arising from the intracranial aneurysm sac, using a 3-tesla MR scanner and an area detector CT scanner. Methods: Fifty patients with an intracranial aneurysm (25 patients with a branch vessel arising from the sac and 25 patients without) underwent rotational intraarterial digital subtraction angiography (rotational DSA), MRA, and CFA. The following six image sets were assessed using a 3-point scale for the existence of a branch vessel; (1) volume rendering with MRA (MRA-VR); (2) CTA-VR; (3) source images with MRA; (4) source images with CTA; (5) VR and source images with MRA ('MRA-VR+source images'); and (6) 'CTA-VR+source images'. Each set comprised the data of all 50 patients. Three radiologists then performed consensus review and calculated the sensitivity, specificity, and accuracy for MRA and CTA; rotational DSA was considered as the gold standard. Results: Higher accuracies were obtained in review using VR+source compared with both VR and source alone. In addition, higher accuracies were obtained in review using MRA compared with CTA. The highest accuracy of 0.96 was obtained for 'MRA-VR+source images'; in contrast, accuracy on 'CTA-VR+source images' was 0.86. Conclusions: The results show that 3-tesla MRA is an ideal non-invasive imaging examination for detection of a branch vessel arising from an intracranial aneurysm sac. Higher accuracy, especially sensitivity, with MRA compared with CTA was found in ICA, but accuracy with MRA was same as that with CTA in MCA. (C) 2014 Elsevier B.V. All rights reserved.
  • Masaki Katsura, Yuichi Suzuki, Junichi Hata, Masaaki Hori, Hiroki Sasaki, Hiroyuki Akai, Harushi Mori, Akira Kunimatsu, Yoshitaka Masutani, Shigeki Aoki, Kuni Ohtomo
    JOURNAL OF MAGNETIC RESONANCE IMAGING 40 5 1208 - 1214 2014年11月 [査読無し][通常論文]
    Purpose: To investigate the use of non-Gaussian diffusion-weighted imaging (q-space imaging [QSI]) to estimate diurnal changes in intervertebral disc (IVD) microstructure. Materials and Methods: IVDs of 15 male subjects (mean age, 27.3 years; mean body mass index, 22.50 kg/m(2)) were investigated once in the morning, less than 30 min after rising, and a second time in the evening after at least 10 h of normal physical activity, using 3 Tesla (T) MR imaging. T2 mapping and QSI data values (apparent diffusion coefficient [ADC], root mean square displacement [RMSD], and apparent kurtosis coefficient [AKC]) were calculated and compared between the morning and evening imaging sessions. Results: The T2, ADC, and RMSD values showed a significant decrease in the evening (175.8 +/- 49.5 ms, 1.56 +/- 0.32 10(-3) mm(2)/s and 40.0 +/- 3.0 mu m, respectively; P < 0.05 for all values; paired t-test), when compared with the morning values (226.5 +/- 83.8 ms, 1.69 +/- 0.29 10(-3) mm(2)/s and 45.2 +/- 2.9 mm, respectively). The AKC value showed a significant increase in the evening (0.67 +/- 0.08), when compared with the morning value (0.58 +/- 0.04; P < 0.05). Conclusion: The RMSD and AKC values obtained from QSI analysis may be biomarkers for IVD diurnal microstructural changes.
  • Masaki Katsura, Satoshi Hirose, Hiroki Sasaki, Harushi Mori, Akira Kunimatsu, Kuni Ohtomo, Koji Jimura, Seiki Konishi
    PLOS ONE 9 10 2014年10月 [査読無し][通常論文]
    Previous studies have revealed top-down control during memory retrieval from the prefrontal cortex to the temporal cortex. In the present functional MRI study, we investigated whether the fronto-temporal functional interaction occurs even during fixation periods after memory retrieval trials. During recency judgments, subjects judged the temporal order of two items in a study list. The task used in the present study consisted of memory trials of recency judgments and non-memory trials of counting dots, and post-trial fixation periods. By comparing the brain activity during the fixation periods after the memory trials with that during the fixation periods after the non-memory trials, we detected heightened brain activity in the lateral prefrontal cortex, the lateral temporal cortex and the hippocampus. Functional interactions during the fixation periods after the memory vs. non-memory trials as examined using a psychophysiological interaction revealed a decreased interaction from the lateral prefrontal cortex to the lateral temporal cortex, but not to the hippocampus. The functional interaction between the same frontal and temporal regions was also present during the memory trials. A trial-based functional connectivity analysis further revealed that the fronto-temporal interaction was positive and decreased during the fixation periods after the memory trials, relative to the fixation periods after the non-memory trials. These results suggest that the fronto-temporal interaction existed during the post-trial fixation periods, which had been present during the memory trials and temporally extended into the fixation periods.
  • Mayumi Hangai, Yuki Kimura, Harushi Mori, Kojiro Yasui, Shinya Tsuchida, Naoto Takahashi
    PEDIATRICS INTERNATIONAL 56 4 623 - 626 2014年08月 [査読無し][通常論文]
    Neonatal subgaleal hemorrhage (SGH) is a serious adverse event that is often underestimated and sometimes goes unrecognized. It can cause bleeding complications and jeopardize the patient's life. Early diagnosis and prompt treatment are important in optimizing the outcome in neonates with SGH. Herein we describe the case of a newborn who developed severe SGH and died. We report unenhanced computed tomography (CT) of ongoing SGH, which showed a low-density region in the surrounding area of the head. The density could be explained by unclotted active bleeding and low hematocrit. Even if a patient with clinically suspected SGH has a low-density region on CT, the presence of SGH should not be excluded.
  • Kazunori Ichikawa, Akinori Kashio, Harushi Mori, Atushi Ochi, Shotaro Karino, Takashi Sakamoto, Akinobu Kakigi, Tatsuya Yamasoba
    OTOLARYNGOLOGY-HEAD AND NECK SURGERY 150 4 646 - 653 2014年04月 [査読無し][通常論文]
    Objective To develop a new method to determine the presence of intracochlear ossification and/or fibrosis in cochlear implantation candidates with bilateral profound deafness following meningitis. Study Design Diagnostic test assessment. Setting A university hospital. Subjects and Methods This study involved 15 ears from 13 patients with profound deafness following meningitis who underwent cochlear implantation. These ears showed normal structures, soft tissue, partial bony occlusion, and complete bony occlusion in 4, 3, 2, and 6 ears, respectively. We measured radiodensity in Hounsfield units (HU) using 0.5-mm-thick axial high-resolution computed tomography image slices at 3 different levels in the basal turn, the fenestration, and inferior and ascending segment sites, located along the electrode-insertion path. Pixel-level analysis on the DICOM viewer yielded actual computed tomography values of intracochlear soft tissues by eliminating the partial volume effect. The values were compared with the intraoperative findings. Results Values for ossification (n = 12) ranged from +547 HU to +1137 HU; for fibrosis (n = 11), from +154 HU to +574 HU; and for fluid (n = 22), from -49 HU to +255 HU. From these values, we developed 2 presets of window width (WW) and window level (WL): (1) WW: 1800, WL: 1100 (200 HU to 2000 HU) and (2) WW: 1500, WL: 1250 (500 HU to 2000 HU). The results using these 2 presets corresponded well to the intraoperative findings. Conclusion Our new method is easy and feasible for preoperative determination of the presence of cochlear ossification and/or fibrosis that develops following meningitis.
  • Jun-ichi Takanashi, Hitoshi Osaka, Hirotomo Saitsu, Masayuki Sasaki, Harushi Mori, Hidehiro Shibayama, Manabu Tanaka, Yoshiko Nomura, Yasuo Terao, Ken Inoue, Naomichi Matsumoto, A. James Barkovich
    BRAIN & DEVELOPMENT 36 3 259 - 263 2014年03月 [査読無し][通常論文]
    Background: Mutations of POLR3A and POLR3B have been reported to cause several allelic hypomyelinating disorders, including hypomyelination with hypogonadotropic hypogonadism and hypodontia (4H syndrome). Patients and methods: To clarify the difference in MRI between the two genotypes, we reviewed MRI in three patients with POLR3B mutations, and three with POLR3A mutations. Results: Though small cerebellar hemispheres and vermis are common MRI findings with both types of mutations, MRI in patients with POLR3B mutations revealed smaller cerebellar structures, especially vermis, than those in POLR3A mutations. MRI also showed milder hypomyelination in patients with POLR3B mutations than those with POLR3A mutations, which might explain milder clinical manifestations. Conclusions: MRI findings are distinct between patients with POLR3A and 3B mutations, and can provide important clues for the diagnosis, as these patients sometimes have no clinical symptoms suggesting 4H syndrome. (C) 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
  • Masami Goto, Osamu Abe, Shigeki Aoki, Hidemasa Takao, Naoto Hayashi, Tosiaki Miyati, Harushi Mori, Akira Kunimatsu, Kenji Ino, Keiichi Yano, Kuni Ohtomo
    JOURNAL OF MAGNETIC RESONANCE IMAGING 39 1 132 - 142 2014年01月 [査読無し][通常論文]
    PurposeTo show the gray matter volumes in the default mode network (DMN) using the atlas-based method and to evaluate age-related volume change in the DMN region. Estimation of gray matter volumes is interesting research because previous reports showed an association with gray matter volume (GMV) and diseases. Materials and MethodsWe focused on five nodes of the DMN (posterior cingulate, precuneus, lateral temporal cortex [LTC], medial prefrontal cortex, and inferior parietal lobule). In all, 1122 healthy adults were included in the present study. T1-weighted magnetic resonance (MR) images were obtained using a 3T-MR scanner. To investigate GMV in the DMN, segmented gray matter images were measured by the atlas-based method, using Statistical Parametric Mapping 5. Volumes were expressed using three different methods: region of interest (ROI)-volume (mL), the volume itself; ROI-TIV (%), as a percentage of total intracranial volume (individual difference of head size is corrected); and ROI-GMV (%), as a percentage of gray matter volume (individual difference of atrophy speed for aging is corrected). ResultsNegative correlations between measurement values on ROI and age were observed in all five ROIs of the DMN region by two measures of volume (ROI-volume (mL) and ROI-TIV (%)), in both genders. In contrast, positive correlations between measurement values on ROI and age were observed in the posterior cingulate and LTC with ROI-GMV (%), in both genders. ConclusionThe present study is the first report about volume change in the DMN that includes age-related effects. J. Magn. Reson. Imaging 2014;39:132-142. (c) 2013 Wiley Periodicals, Inc.
  • Masami Goto, Osamu Abe, Tosiaki Miyati, Shigeki Aoki, Hidemasa Takao, Naoto Hayashi, Harushi Mori, Akira Kunimatsu, Kenji Ino, Keiichi Yano, Kuni Ohtomo
    Journal of Magnetic Resonance Imaging 38 4 958 - 962 2013年10月 [査読無し][通常論文]
    Purpose To show an association between T2-weighted signal intensity (T2-SI) variation and missegmentation in the putamen of healthy adults, using 3.0-tesla magnetic resonance scanner and voxel-based morphomery (VBM). Materials and Methods Contiguous sagittal T1-weighted images and axial T2-weighted images of the brain were obtained from 1380 healthy participants using a 3.0 Tesla (T) MR scanner. After image preprocessing with Statistical Parametric Mapping 5, the association between T2-SI ratio (= A/B, where A is the mean of the T2-SI in the putamen, and B is that in the thalamus) variation and gray matter missegmentation was assessed using VBM. Results A significant positive correlation was revealed between T2-SI ratio and bilateral putamen volume on the gray matter images. In addition, we found a significant negative correlation between T2-SI ratio and bilateral putamen volume on the white matter images. We consider that these results show the influence of missegmentation. Conclusion To the best of our knowledge, this is the first VBM study to demonstrate an association between T2-SI variation and gray matter missegmentation. These results indicate the possibility that VBM may be more affected by individual differences in iron content levels than by individual differences in tissue volumes if detected-regions with VBM contained substantial iron deposition. Copyright © 2012 Wiley Periodicals, Inc.
  • Masami Goto, Osamu Abe, Shigeki Aoki, Naoto Hayashi, Tosiaki Miyati, Hidemasa Takao, Takeshi Iwatsubo, Fumio Yamashita, Hiroshi Matsuda, Harushi Mori, Akira Kunimatsu, Kenji Ino, Keiichi Yano, Kuni Ohtomo
    NEURORADIOLOGY 55 7 869 - 875 2013年07月 [査読無し][通常論文]
    This study aimed to investigate whether the effect of scanner for cortex volumetry with atlas-based method is reduced using Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) normalization compared with standard normalization. Three-dimensional T1-weighted magnetic resonance images (3D-T1WIs) of 21 healthy subjects were obtained and evaluated for effect of scanner in cortex volumetry. 3D-T1WIs of the 21 subjects were obtained with five MRI systems. Imaging of each subject was performed on each of five different MRI scanners. We used the Voxel-Based Morphometry 8 tool implemented in Statistical Parametric Mapping 8 and WFU PickAtlas software (Talairach brain atlas theory). The following software default settings were used as bilateral region-of-interest labels: "Frontal Lobe," "Hippocampus," "Occipital Lobe," "Orbital Gyrus," "Parietal Lobe," "Putamen," and "Temporal Lobe." Effect of scanner for cortex volumetry using the atlas-based method was reduced with DARTEL normalization compared with standard normalization in Frontal Lobe, Occipital Lobe, Orbital Gyrus, Putamen, and Temporal Lobe; was the same in Hippocampus and Parietal Lobe; and showed no increase with DARTEL normalization for any region of interest (ROI). DARTEL normalization reduces the effect of scanner, which is a major problem in multicenter studies.
  • Sachiko Inano, Hidemasa Takao, Naoto Hayashi, Naoki Yoshioka, Harushi Mori, Akira Kunimatsu, Osamu Abe, Kuni Ohtomo
    Journal of Magnetic Resonance Imaging 37 5 1072 - 1076 2013年05月 [査読無し][通常論文]
    Purpose: To investigate age-related differences, gender differences, and age-by-gender interactions on the volumes of 18 neuroanatomical structures, with a large sample at a single institution. Materials and Methods: A total of 861 normal subjects (mean age = 56.1 ± 9.8 years, age range = 24.0-84.8 years) were included in this study. All subjects were scanned at 3.0 T. Measurement of the 18 neuroanatomical volumes was performed with FreeSurfer v. 4.5. Differences in volumes of neuroanatomical structures were tested using analysis of covariance with intracranial volume-normalized volume as the dependent variable, and independent variables of age, sex, age × sex, age × age, age × age × sex, and scanner. Nonsignificant higher-order terms were removed sequentially from the model. A P value of < 0.0028 (=0.5/18) was considered to indicate a statistically significant difference. Results: All neuroanatomical volumes, except for the caudate nucleus, pallidum, and 4th ventricle, were significantly related to age (linearly or quadratically). Significant gender differences were found in all neuroanatomical volumes, except for cerebral white matter, cerebellar cortex, caudate nucleus, and amygdala. No neuroanatomical volume showed a significant interaction between age (age × age) and gender. Conclusion: Our results showed age and gender effects on neuroanatomical volumes, and indicate no gender difference in the aging process of neuroanatomical volumes. © 2012 Wiley Periodicals, Inc.
  • Kouhei Kamiya, Noriko Sato, Miho Ota, Yasuhiro Nakata, Kimiteru Ito, Yukio Kimura, Miho Murata, Harushi Mori, Akira Kunimatsu, Kuni Ohtomo
    JOURNAL OF NEURORADIOLOGY 40 2 121 - 129 2013年05月 [査読無し][通常論文]
    Objectives: The uncinate fasciculus (UF), a major white-matter tract connecting the frontal and temporal lobes, is related to cognitive/behavioral function. Recently, the UF has been suggested to constitute an indirect pathway of the "semantic ventral pathway" in association with the inferior longitudinal fasciculus (ILF). This retrospective study aimed to evaluate damage to the UF and ILF in patients with progressive supranuclear palsy (PSP) using diffusion tensor tract-specific analysis. Material and methods: Diffusion tensor imaging (DTI) of 16 PSP patients with Richardson's syndrome (PSP-RS) and 21 age-matched volunteers were obtained. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values for the bilateral UF and ILF were calculated by tract-specific analysis. Student's t test was used to evaluate the differences between the patients and controls. Also, voxel-based morphometry (VBM) was performed using 3D T1-weighted images to explore the regional atrophy of gray matter in the patients. Results: In patients with PSP-RS, FA of the left UF was significantly decreased compared with the controls, while significant increases in ADC were found in the UF and ILF bilaterally. VBM analysis showed significant clusters of reduced gray matter in the frontal cortex (predominantly in the lateral orbitofrontal cortex, pars opercularis and mesial frontal cortex) and subcortical nuclei (midbrain, caudate and thalamic). Conclusion: This study has shown that patients with PSP-RS had impairment of the UF and ILF. Damage to the UF is thought to be related to atrophy of the orbitofrontal cortex and may possibly be correlated with the cognitive/behavioral impairment seen in PSR (C) 2012 Elsevier Masson SAS. All rights reserved.
  • Kouhei Kamiya, Akira Kunimatsu, Harushi Mori, Jiro Sato, Masaaki Akahane, Takana Yamakawa, Kuni Ohtomo
    Japanese Journal of Radiology 31 4 293 - 298 2013年04月 [査読無し][通常論文]
    Purpose: This study aimed to evaluate whether the image quality of virtual monochromatic spectral imaging with fast kVp switching dual-energy CT (DECT) can be comparable to that of 120-kVp single-energy CT (SECT) without increasing the radiation dose. Materials and methods: We retrospectively identified 15 postoperative patients who had undergone both DECT and 120-kVp SECT within a short period of time for follow-up after brain surgery. Simulated 65 keV monochromatic images were reconstructed from DECT data. Subjective image noise, gray-white matter contrast, and overall image quality were rated using a four-point scale. Quantitative measurement of noise, contrast-to-noise ratio (CNR), and posterior fossa beam-hardening artifact were also performed. The figure of merit (FOM), calculated as CNR2/CTDIvol, was used to quantify image quality improvement per exposure risk. Results: The mean CTDIvol was 70.2 ± 0.3 mGy for DECT, which was 11 % lower than SECT (78.9 ± 2.1 mGy). All images were graded above clinically acceptable. Quantitative and qualitative measures for simulated 65-keV images were comparable with SECT images, except for increase in subjective noise. FOM was significantly greater for simulated 65-keV images (P =.03). Conclusion: Our results indicate that virtual monochromatic imaging possibly provides comparable image quality to that afforded by 120-kVp SECT without increasing the dose in routine head CT. © 2013 Japan Radiological Society.
  • K. Kamiya, N. Sato, Y. Nakata, K. Ito, Y. Kimura, M. Ota, A. Takahashi, H. Mori, A. Kunimatsu, K. Ohtomo
    American Journal of Neuroradiology 34 3 524 - 532 2013年03月 [査読無し][通常論文]
    BACKGROUND AND PURPOSE: Restriction of diffusion has been reported in the early phase of secondary neuronal degeneration, such as Wallerian degeneration. The purpose of this study was to investigate postoperative transient reduced diffusion in the ipsilateral striatum and thalamus as a remote effect of surgery. MATERIALS AND METHODS: Six hundred two postoperative MR imaging examinations in 125 patients after cerebral surgery were retrospectively reviewed, focusing on the presence of reduced diffusion in the striatum and/or thalamus. The distribution of reduced diffusion in the striatum was classified into 3 groups: anterior, central, and posterior. Reduced diffusion in the thalamus was also classified on the basis of the anatomic locations of the thalamic nuclei. Further follow-up MRI was available in all patients with postoperative reduced diffusion, and acute infarctions were excluded. The patient medical records were reviewed to evaluate neurologic status. RESULTS: Restriction of diffusion was observed in the striatum and/or thalamus ipsilateral to the surgical site in 17 patients (13.6%). The distribution of signal abnormality correlated with the location of the operation, in concordance with the architecture of the striatocortical and thalamocortical connections. Reduced diffusion was observed from days 7 to 46 after the operation, especially during days 8-21. The signal abnormalities completely resolved on follow-up examinations. The median follow-up period was 202 days (interquartile range, 76-487 days). CONCLUSIONS: Postoperative transient reduced diffusion in the ipsilateral striatum and/or thalamus likely represents an early phase of secondary neuronal degeneration based on its characteristic distribution and time course. Clinically, this reduced diffusion should not be mistaken for postoperative ischemic injury.
  • Masami Goto, Osamu Abe, Shigeki Aoki, Tosiaki Miyati, Hidemasa Takao, Naoto Hayashi, Harushi Mori, Akira Kunimatsu, Kenji Ino, Keiichi Yano, Kuni Ohtomo
    Neuroradiology 55 2 245 - 250 2013年02月 [査読無し][通常論文]
    Introduction: The aim of the present study was to investigate the correlation between local gray matter volume and signal-to-noise ratio on T2-weighted imaging (T2-SNR) of putamen in healthy adults using two tools: voxel-based morphometry (VBM) treating age as a confounding covariate to control for age-related gray matter volume changes and high spatial resolution T1-weighted imaging acquired with a 3.0-T magnetic resonance (3T-MR) scanner. Methods: Contiguous sagittal T1-weighted images and axial T2-weighted images of the brain were obtained from 1,380 healthy participants. T2-SNR of putamen was defined as A/B, where A is the mean T2-weighted signal intensity (T2-SI) in the right and left sides of putamen, and B is the background noise. The software Statistical Parametric Mapping 5 was used for image segmentation. The association between T2-SNR of putamen and gray matter volume was assessed with VBM, treating age as a confounding covariate. Results: A significant positive correlation was obtained between T2-SNR of putamen and bilateral pre- and postcentral gyrus volume. Conclusion: To the best of our knowledge, this is the first VBM study to show an age-independent relationship between T2-SNR of putamen and bilateral pre- and postcentral gyrus volumes in healthy adults. © 2012 Springer-Verlag Berlin Heidelberg.
  • Takanobu Mashiko, Harushi Mori, Harunosuke Kato, Kentaro Doi, Shinichiro Kuno, Kahori Kinoshita, Akira Kunimatsu, Kuni Ohtomo, Kotaro Yoshimura
    Plastic and Reconstructive Surgery - Global Open 1 1 2013年 [査読無し][通常論文]
    Background: Hyaluronic acid (HA) fillers have become the most popular tool for wrinkle treatment and volumization, although HA is generally absorbed within 6-12 months and requires repeated treatments to maintain the effects. Methods: HA was injected onto the bone for volumization with a small 30-gauge needle to examine the long-lasting effects. Of the 63 Japanese patients with 97 treated sites followed up more than 12 months, 51 had HA injections for cosmetic purposes and 12 were treated for reconstructive volumization of facial deformity such as localized scleroderma and postsurgical bony deformity. Treated sites included the forehead, temple, nasal root, mentum, tear trough, and infraorbital sulcus. Results: After long-term follow-up (12-93 months, mean = 21.6), persistent volumizing effects were observed in most patients. In fact, 86.6% of the treated sites showed > 50% volume retention and 49.5% showed > 75% retention. Magnetic resonance imaging analyses revealed that the injected space was well maintained, capsulated, and filled with heterogeneous content. Magnetic resonance imaging quantitative T2 maps indicated that much of the injected HA was replaced with other materials. Together with clinical inspection, these findings suggest that onlay injection of HA on the bone induced formation of capsule, fibrosis, and/or calcification/ ossification, which contributed to persistent volumization. Conclusions: Semipermanent volumizing effects can be achieved by HA injection if the target area has an underlying bony floor. Periosteal stem cells may be activated by HA injection and may contribute to persistent volumizing effects. This treatment may be a much less invasive alternative to fat or bone grafting.
  • Yayoi K. Hayakawa, Hiroki Sasaki, Hidemasa Takao, Harushi Mori, Naoto Hayashi, Akira Kunimatsu, Shigeki Aoki, Kuni Ohtomo
    JOURNAL OF AFFECTIVE DISORDERS 144 3 263 - 268 2013年01月 [査読無し][通常論文]
    Background: Brain structural changes accompany major depressive disorder, but whether subclinical depression is accompanied by similar changes in brain volume and white matter integrity is unknown. By using voxel-based morphometry (VBM) of the gray matter and tract-specific analysis based on diffusion tensor imaging (DTI) of the white matter, we explored the extent to which abnormalities could be identified in specific brain structures of healthy adults with subclinical depression. Methods: The subjects were 21 community-dwelling adults with subclinical depression, as measured by their Center for Epidemiologic Studies Depression Scale (CES-D) scores. They were not demented and had no neurological or psychiatric history. We collected brain magnetic resonance images of the patients and of 21 matched control subjects, and we used VBM to analyze the differences in regional gray matter volume between the two groups. Moreover, we examined the white matter integrity by using tract-specific analysis based on the gray matter volume changes revealed by VBM. Results: VBM revealed that the volumes of both anterior cingulate gyri and the right rectal gyrus were smaller in subclinically depressed women than in control women. Calculation of DTI measures in the anterior cingulum bundle revealed a positive correlation between CES-D scale score and radial diffusivity in the right anterior cingulum in subclinically depressed women. Limitations: The small sample size limits the stability of the reported findings. Conclusions: Gray matter volume reduction and white matter integrity change in specific frontal brain regions may be associated with depressive symptoms in women, even at a subclinical level. (C) 2012 Elsevier B.V. All rights reserved.
  • Masami Goto, Akira Kunimatsu, Masaaki Shojima, Osamu Abe, Shigeki Aoki, Naoto Hayashi, Harushi Mori, Kenji Ino, Keiichi Yano, Nobuhito Saito, Kuni Ohtomo
    MAGNETIC RESONANCE IN MEDICAL SCIENCES 12 1 53 - 56 2013年 [査読無し][通常論文]
    We present a case in which the origin of the branching vessel at the aneurysm neck was observed at the wrong place on the volume rendering method (VR) with 3D time-of-flight MRA (3D-TOF-MRA) with 3-Tesla MR system. In 3D-TOF-MRA, it is often difficult to observe the origin of the branching vessel, but it is unusual for it to be observed in the wrong place. In the planning of interventional treatment and surgical procedures, false recognition, as in the unique case in the present report, is a serious problem. Decisions based only on VR with 3D-TOF-MRA can be a cause of suboptimal selection in clinical treatment.
  • Kazuhiro Tsuchiya, Shigeki Aoki, Keigo Shimoji, Harushi Mori, And Akira Kunimatsu
    Magnetic Resonance in Medical Sciences 12 2 87 - 93 2013年 [査読無し][通常論文]
    Purpose: Time-resolved contrast-enhanced magnetic resonance (MR) angiography (TCMRA) and perfusion MR imaging (PWI) have been used to assess the hemodynamics of brain tumors. We assessed the feasibility and value of consecutive performance of these techniques to evaluate suspected brain metastasis following supplementary injection of gadolinium-based contrast medium. Methods: In 69 patients with suspected brain metastasis, we obtained precontrast MR images followed by TCMRA and postcontrast T1-weighted images after administration of 0.1 mmol/kg gadoteridol. When findings were negative or equivocal, we injected an additional 0.1-mmol/kg dose of gadoteridol and obtained PWI and second postcontrast T1- weighted images. We used a 3-point scale to grade perfusion maps and TCMRA and assessed whether these techniques added information to conventional MR imaging in the differential diagnosis. We also evaluated whether the second contrast injection improved the conspicuity and/or number of enhancing lesions and used a 4-point scoring system to quantitatively analyze diagnostic yield of TCMRA and PWI. Results: We could assess tumor hemodynamics on PWI maps and TCMRA images in all 69 patients. In 14 cases (20%), PWI and/or TCMRA added information to conventional MR findings. After second injection of contrast medium, lesion conspicuity improved in 58 of the 69 cases (84%), and the number of detected lesions increased in 11 of 31 cases diagnosed with metastatic disease (36%). Quantitative analysis revealed TCMRA and PWI provided significant additional diagnostic information (Kruskal-Wallis test, P< 0.0001). Conclusion: Consecutive acquisition of TCMRA and PWI using supplementary contrast injection can facilitate differential diagnosis of suspected brain metastasis and improve the number and conspicuity of detected lesions. © 2013 Japanese Society for Magnetic Resonance in Medicine.
  • Kouhei Kamiya, Harushi Mori, Akira Kunimatsu, Kensuke Kawai, Kenichi Usami, Kuni Ohtomo
    JOURNAL OF NEURORADIOLOGY 39 5 360 - 363 2012年12月 [査読無し][通常論文]
    This is a report of two cases of spontaneous temporal encephalocele: one was anteroinferior and presented with epilepsy; the other was posteroinferior and presented with facial neuritis and labyrinthitis. Spontaneous temporal encephalocele is relatively rare and apparently not familiar to a majority of primary physicians. It may present with a variety of symptoms according to its anatomical location, including cerebrospinal fluid fistulas, recurrent meningitis, chronic otitis media, hearing loss, facial nerve palsy and medically intractable epilepsy. Attention should be paid to this disease entity, as it is easily overlooked in imaging studies and can leave serious neurological deficits. (C) 2012 Elsevier Masson SAS. All rights reserved.
  • K. Toyoda, H. Oba, K. Kutomi, S. Furui, A. Oohara, H. Mori, K. Sakurai, K. Tsuchiya, S. Kan, Y. Numaguchi
    AMERICAN JOURNAL OF NEURORADIOLOGY 33 11 2136 - 2139 2012年12月 [査読無し][通常論文]
    IgG4-related disease is characterized by histologic fibrosis with IgG4-positive plasma cell infiltration. Our study evaluated MR imaging features of IgG4-related disease in the head and neck and brain. Images from 15 patients were retrospectively evaluated for the location, signal intensity, and enhancement patterns of lesions. Lacrimal gland enlargement was observed in 8 cases. Other lesions included orbital pseudotumor in 5, pituitary enlargement in 5, and cranial nerve enlargement in 7; the infraorbital nerve was involved in 4. All lesions were hypointense on T2-weighted images, which is typical for IgG4-related lesions. Multiple sites were involved in the head and neck and brain in 11 patients. The diagnosis of IgG4-related disease should be considered in a patient presenting with T2 hypointense lacrimal gland, pituitary, or cranial nerve enlargement, or a T2 hypointense orbital mass, especially if multiple sites in the head and neck are involved in the presence of elevated serum IgG4.
  • 【癌取扱い規約からみた悪性腫瘍の病期診断と画像診断2012年版】眼部腫瘍 眼内腫瘍
    豊田 圭子, 森 墾, 大原 有紗, 大場 洋
    臨床放射線 57 11 1607 - 1619 金原出版(株) 2012年10月
  • Harushi Mori
    INTERNATIONAL JOURNAL OF UROLOGY 19 9 812 - 812 2012年09月 [査読無し][通常論文]
  • Tokumi Ishii
    INTERNATIONAL JOURNAL OF UROLOGY 19 9 811 - 811 2012年09月 [査読無し][通常論文]
  • Keiko Shimojima, Akihisa Okumura, Harushi Mori, Shinpei Abe, Mitsuru Ikeno, Toshiaki Shimizu, Toshiyuki Yamamoto
    AMERICAN JOURNAL OF MEDICAL GENETICS PART A 158A 9 2272 - 2276 2012年09月 [査読無し][通常論文]
    The 5q14.3 microdeletion syndrome has recently been recognized as a clinical entity manifesting as severe intellectual disability, epilepsy, and brain malformations. Analysis of the shortest region of overlap among patients with this syndrome and subsequent identification of nucleotide alterations in the coding region of myocyte enhancer factor 2C gene (MEF2C) have suggested MEF2C as the gene responsible for the 5q14.3 microdeletion syndrome. We identified a de novo 3.4-Mb deletion of 5q14.3 in a patient with infantile spasms, microcephaly, and brain malformation. The deleted region in the present patient was positional toward the centromere, and MEF2C was not included in the deleted region. However the neurological and dysmorphic features of the present patient resembled those of patients with the 5q14.3 microdeletion syndrome. We consider that a positional effect is the likely explanation for this evidence. To study the precise mechanism of this positional effect, further information is required on patients showing atypical deletions neighboring MEF2C. (C) 2012 Wiley Periodicals, Inc.
  • Ayako Hiraiwa-Sofue, Yoshinori Ito, Harushi Mori, Takashi Ichiyama, Akihisa Okumura
    JOURNAL OF THE NEUROLOGICAL SCIENCES 320 1-2 145 - 148 2012年09月 [査読無し][通常論文]
    Encephalitis/encephalopathy is a rare, but severe, complication of pertussis. Here, we report a case of an unimmunized 7-year-old boy with confirmed pertussis complicated by acute encephalitis/encephalopathy. Eighteen days after the onset of pertussis, generalized seizures began. Magnetic resonance imaging (MRI) indicated that marked demyelination without cytotoxic edema may have occurred to the patient Notably, this is the first report to show precise MRI findings of pertussis-associated encephalitis/encephalopathy. Markedly increased myelin basic protein levels in the cerebrospinal fluid were consistent with the MRI findings. There was no evidence of direct invasion of the causative bacterium or its products into the central nervous system. The levels of interleukin-6 and -10 in the cerebrospinal fluid were higher than those in serum. Taken together, we conclude that indirect immune-mediated mechanisms may have contributed to the pathogenesis of the encephalitis/encephalopathy. (C) 2012 Elsevier B.V. All rights reserved.
  • Harushi Mori, Masayuki Maeda, Jun-ichi Takanashi, Akira Kunimatsu, Nobuyoshi Matsushima, Hidenori Suzuki, Nobuhito Saito, Kuni Ohtomo
    JOURNAL OF CLINICAL NEUROSCIENCE 19 8 1182 - 1184 2012年08月 [査読無し][通常論文]
    Reversible splenial lesions (RSL) of the corpus callosum have been described in various clinical conditions, and some are attributed to the action of antiepileptic drugs (AED). Abrupt withdrawal of an AED in preparation for surgical treatment can result in RSL of the corpus callosum in patients with trigeminal neuralgia who do not have epilepsy. We report two patients who developed RSL following surgical treatment of trigeminal neuralgia. Since our two patients did not have epilepsy, it is strongly suggested that the AED, rather than convulsive status epilepticus, could be a contributing factor in RSL. The pathogenesis of AED-associated RSL is not clear. Similar RSL can appear under various circumstances, implying that factors other than AED can influence a common end-point mechanism that results in RSL. Nevertheless, delirium after surgery may be a cue for inquiring about RSL. This condition is transient and represents a clinicoradiological syndrome with an excellent prognosis. We should consider this phenomenon in the perioperative period after surgery for trigeminal neuralgia to avoid invasive diagnostic and therapeutic procedures. (c) 2011 Elsevier Ltd. All rights reserved.
  • Masaki Katsura, Harushi Mori, Akira Kunimatsu, Hiroki Sasaki, Osamu Abe, Toru Machida, Kuni Ohtomo
    NEURORADIOLOGY 54 8 873 - 882 2012年08月 [査読無し][通常論文]
    Immunoglobulin (Ig) G4-related disease is a recently designated benign clinical entity histopathologically characterized by sclerosing inflammation and infiltration of numerous IgG4+ plasma cells that affects multiple organs. The purpose of this study is to characterize the imaging findings of patients with histopathologically proven IgG4-related disease in the head, neck, and brain. A total of 17 patients (15 males, 2 females; mean age, 66.1 +/- 7.4 years) with histopathologically proven IgG4-related disease in the head, neck, and brain were identified in two hospitals between January 2004 and December 2010. Imaging findings were retrospectively reviewed, with particular attention to the location and number of lesions, internal architecture, enhancement patterns, presence of vascular occlusion or compression, and changes in adjacent bones. The lesions, presented as either enlarged gland(s), or focal, localized nodules/masses, were distributed in the lacrimal gland (n = 7), the parotid gland (n = 14), the submandibular gland (n = 10), the pituitary gland (n = 2), skull base dura mater (n = 2), and the pterygopalatine fossa (n = 3). All lesions were well-defined and iso- to hypointense on T2-weighted magnetic resonance images and showed homogeneous enhancement. No lesion showed vascular occlusion or compression. Bones adjacent to the lesions showed remodeling (erosion or sclerosis) without signs of destruction (n = 6). Four patients had lesions involving multiple areas which extended along the trigeminal nerve, accompanied by expansion of neural foramina along their courses, with no signs of bone destruction. Sites of predilection for IgG4-related disease in the head, neck, and brain include the lacrimal, salivary, and pituitary glands. Recognition of the typical radiological features of IgG4-related disease, such as well-defined lesion borders, T2 hypointensity, homogeneous and gradual enhancement pattern, absence of vascular occlusion or compression, and presence of bone remodeling without destruction, may be of help in the diagnosis of this benign clinical entity.
  • Taichi Kin, Hirofumi Nakatomi, Masaaki Shojima, Minoru Tanaka, Kenji Ino, Harushi Mori, Akira Kunimatsu, Hiroshi Oyama, Nobuhito Saito
    JOURNAL OF NEUROSURGERY 117 1 78 - 88 2012年07月 [査読無し][通常論文]
    Object. In this study, the authors used preoperative simulation employing 3D computer graphics (interactive computer graphics) to fuse all imaging data for brainstem cavernous malformations. The authors evaluated whether interactive computer graphics or 2D imaging correlated better with the actual operative field, particularly in identifying a developmental venous anomaly (DVA). Methods. The study population consisted of 10 patients scheduled for surgical treatment of brainstem cavernous malformations. Data from preoperative imaging (MRI, CT, and 3D rotational angiography) were automatically fused using a normalized mutual information method, and then reconstructed by a hybrid method combining surface rendering and volume rendering methods. With surface rendering, multimodality and multithreshold techniques for 1 tissue were applied. The completed interactive computer graphics were used for simulation of surgical approaches and assumed surgical fields. Preoperative diagnostic rates for a DVA associated with brainstem cavernous malformation were compared between conventional 2D imaging and interactive computer graphics employing receiver operating characteristic (ROC) analysis. Results. The time required for reconstruction of 3D images was 3-6 hours for interactive computer graphics. Observation in interactive mode required approximately 15 minutes. Detailed anatomical information for operative procedures, from the craniotomy to microsurgical operations, could be visualized and simulated three-dimensionally as 1 computer graphic using interactive computer graphics. Virtual surgical views were consistent with actual operative views. This technique was very useful for examining various surgical approaches. Mean (+/- SEM) area under the ROC curve for rate of DVA diagnosis was significantly better for interactive computer graphics (1.000 +/- 0.000) than for 2D imaging (0.766 +/- 0.091; p < 0.001, Mann-Whitney U-test). Conclusions. The authors report a new method for automatic registration of preoperative imaging data from CT, MRI, and 3D rotational angiography for reconstruction into I computer graphic. The diagnostic rate of DVA associated with brainstem cavernous malformation was significantly better using interactive computer graphics than with 2D images. Interactive computer graphics was also useful in helping to plan the surgical access corridor. (http://thejns.org/doi/abs/10.3171/2012.3.JNS111541)
  • Masami Goto, Osamu Abe, Tosiaki Miyati, Hiroyuki Kabasawa, Hidemasa Takao, Naoto Hayashi, Tomomi Kurosu, Takeshi Iwatsubo, Fumio Yamashita, Hiroshi Matsuda, Harushi Mori, Akira Kunimatsu, Shigeki Aoki, Kenji Ino, Keiichi Yano, Kuni Ohtomo
    KOREAN JOURNAL OF RADIOLOGY 13 4 391 - 402 2012年07月 [査読無し][通常論文]
    Objective: Many studies have reported pre-processing effects for brain volumetry; however, no study has investigated whether non-parametric non-uniform intensity normalization (N3) correction processing results in reduced system dependency when using an atlas-based method. To address this shortcoming, the present study assessed whether N3 correction processing provides reduced system dependency in atlas-based volumetry. Materials and Methods: Contiguous sagittal T1-weighted images of the brain were obtained from 21 healthy participants, by using five magnetic resonance protocols. After image preprocessing using the Statistical Parametric Mapping 5 software, we measured the structural volume of the segmented images with the WFU-PickAtlas software. We applied six different bias-correction Levels (Regularization 10, Regularization 0.0001, Regularization 0, Regularization 10 with N3, Regularization 0.0001 with N3, and Regularization 0 with N3) to each set of images. The structural volume change ratio (%) was defined as the change ratio (%) = (100 x [measured volume - mean volume of five magnetic resonance protocols] / mean volume of five magnetic resonance protocols) for each bias-correction level. Results: A low change ratio was synonymous with lower system dependency. The results showed that the images with the N3 correction had a lower change ratio compared with those without the N3 correction. Conclusion: The present study is the first atlas-based volumetry study to show that the precision of atlas-based volumetry improves when using N3-corrected images. Therefore, correction for signal intensity non-uniformity is strongly advised for multi-scanner or multi-site imaging trials.
  • Yuri Kitamura, Akihisa Okumura, Masaharu Hayashi, Harushi Mori, Satoru Takahashi, Keiko Yanagihara, Rie Miyata, Naoyuki Tanuma, Takashi Mimaki, Shinpei Abe, Toshiaki Shimizu
    BRAIN & DEVELOPMENT 34 5 372 - 375 2012年05月 [査読無し][通常論文]
    Glucose transporter type 1 deficiency syndrome is an inborn error of glucose transport across blood tissue barriers, and the modified Atkins diet is an effective and well-tolerated treatment. To investigate the effects of the modified Atkins diet, we examined the cerebrospinal fluid markers and performed phosphorus magnetic resonance spectroscopy in a patient with glucose transporter type 1 deficiency syndrome before and after the modified Atkins diet. Cerebrospinal fluid levels of the oxidative stress markers, 8-hydroxy-2'-deoxyguanosine and hexanoyl-lysine adduct, were markedly increased above the cutoff index and were normalized 18 months after the modified Atkins diet. Phosphorus magnetic resonance spectroscopy measurements showed 18% increase of PCr/gamma-ATP ratio after the modified Atkins diet. These results suggest that the modified Atkins diet may reduce oxidative stress in the brain and improve energy reserve capacity, which is important in sustaining electrophysiological activities essential for performing brain functions. (C) 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
  • Harushi Mori, A. Kunimatsu, O. Abe, H. Sasaki, H. Takao, T. Nojo, K. Kawai, N. Saito, K. Ohtomo
    Neuroradiology Journal 25 2 163 - 171 2012年04月 [査読無し][通常論文]
    It has been suggested that a difference in signal intensity (SI) between the resection cavity and normal cerebrospinal fluid (CSF) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) in partially resected gliomas indicates subsequent or coincident tumor progression. We considered that this would hold true for resected meningiomas as well. Hence, we aimed to assess whether or not such a difference in the SI during the follow-up evaluation helps predict residual or recurrent tumor in resected meningiomas. We evaluated 63 patients with resected meningiomas. The SI within the resection cavity observed on FLAIR images was qualitatively and quantitatively assessed during follow-up. Qualitative analysis comprised visual comparison of the SI in the resection cavity with that of normal CSF by neuroradiologists. The SI in the resection cavity was quantitatively assessed by region of interest (ROI) analysis and normalized against the background noise and CSF SI. Normalized SI recorded during follow-up was compared with that recorded immediately after resection. Tumor progression was defined as a 20% or greater increase in the diameter of the longest residual or recurrent meningioma (Response Evaluation Criteria in Solid Tumors). The sensitivity and specificity of the elevated SI in the resection cavity for indicating residual or recurrent tumor were calculated. Qualitative analysis by FLAIR MRI showed that patients with remnant tumor following surgery had a prolonged SI increase in the resection cavity. Further, SI increase could not always be observed before recurrence, and both SI increase and regrowth remnant/recurrence could be detected in the same MRI examination. In resected meningiomas, leakage of tumor elements into the resection cavity, presumably tumor cells, manifests as an SI increase on FLAIR images and indicates residual or recurrent tumor. However, unlike the previous reports on partially resected gliomas, we concluded that the SI change does not always precede tumor progression or recurrence.
  • Masami Goto, Tosiaki Miyati, Osamu Abe, Hidemasa Takao, Tomomi Kurosu, Naoto Hayashi, Shigeki Aoki, Harushi Mori, Akira Kunimatsu, Kenji Ino, Keiichi Yano, Kuni Ohtomo
    JOURNAL OF DIGITAL IMAGING 25 1 173 - 178 2012年02月 [査読無し][通常論文]
    The aims of this study were to (1) investigate the repeatability of measured volumes using the atlas-based method in each area of the brain, and (2) validate our hypothesis that the repeatability of the measured volumes with the atlas-based method was improved by using smoothed images. T1-weighted magnetic resonance images were obtained in five healthy subjects using the 1.5-T scanner. We used Statistical Parametric Mapping 5 and WFU PickAtlas software (theory of the Talairach brain atlas). Volumes inside region-of-interest (ROI) were measured in ten sets (five subjects x right and left) on six ROIs, respectively. One set comprises five images (one subject x five 3D-T1WIs). The percentage change was defined as [ 100 x (measured volume-mean volume in each set)/mean volume in each set)]. As a result, the average percentage changes using non-smoothed image on each ROI were as follows: gray matter, 0.482%; white matter, 0.375%; cerebrospinal fluid images, 0.731%; hippocampus, 0.864%; orbital gyrus, 1.692%; cerebellum posterior lobe, 0.854%. Using smoothed images with large FWHM resulted in improved repeatability on orbital gyrus. This is the first report of repeatability in each brain structure and improved repeatability with smoothed images using the atlas-based method.
  • Masami Goto, Osamu Abe, Hiroyuki Kabasawa, Hidemasa Takao, Tosiaki Miyati, Naoto Hayashi, Tomomi Kurosu, Takeshi Iwatsubo, Fumio Yamashita, Hiroshi Matsuda, Sachiko Inano, Harushi Mori, Akira Kunimatsu, Shigeki Aoki, Kenji Ino, Keiichi Yano, Kuni Ohtomo
    MAGNETIC RESONANCE IN MEDICAL SCIENCES 11 1 27 - 34 2012年 [査読無し][通常論文]
    Purpose: We aimed to show that correcting image distortion significantly affects brain volumetry using voxel-based morphometry (VBM) and to assess whether the processing of distortion correction reduces system dependency. Materials and Methods: We obtained contiguous sagittal T-1-weighted images of the brain from 22 healthy participants using 1.5- and 3-tesla magnetic resonance (MR) scanners, preprocessed images using Statistical Parametric Mapping 5, and tested the relation between distortion correction and brain volume using VBM. Results: Local brain volume significantly increased or decreased on corrected images compared with uncorrected images. In addition, the method used to correct image distortion for gradient nonlinearity produced fewer volumetric errors from MR system variation. Conclusion: This is the first VBM study to show more precise volumetry using VBM with corrected images. These results indicate that multi-scanner or multi-site imaging trials require correction for distortion induced by gradient nonlinearity.
  • Akira Kunimatsu, Yuichi Suzuki, Kazuchika Hagiwara, Hiroki Sasaki, Harushi Mori, Masaki Katsura, Kuni Ohtomo
    MAGNETIC RESONANCE IN MEDICAL SCIENCES 11 3 205 - 211 2012年 [査読無し][通常論文]
    Susceptibility-weighted angiography (SWAN) is a state-of-the-art 3-dimensional (3D) T-2*-weighted imaging (T-2*WI) technique with multiple echo acquisitions, but its clinical utility remains to be determined. We compared the utility of susceptibility-weighting sequences among SWAN, 3D phase-sensitive magnetic resonance (MR) imaging (PSI), and conventional 2-dimensional (2D) T-2*WI in routine clinical practice. Our results indicate that SWAN can achieve susceptibility weighting more effectively than conventional 2D T-2*WI and as effectively as PSI and requires a much shorter scan time than PSI.
  • Masami Goto, Osamu Abe, Tosiaki Miyati, Takeharu Yoshikawa, Naoto Hayashi, Hidemasa Takao, Sachiko Inano, Hiroyuki Kabasawa, Harushi Mori, Akira Kunimatsu, Shigeki Aoki, Kenji Ino, Kyouhito Iida, Keiichi Yano, Kuni Ohtomo
    NEURORADIOLOGY 53 8 617 - 622 2011年08月 [査読無し][通常論文]
    Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM). T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A P value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant. Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal, T value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal, T value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found. To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing.
  • Masami Goto, Osamu Abe, Tosiaki Miyati, Sachiko Inano, Naoto Hayashi, Shigeki Aoki, Harushi Mori, Akira Kunimatsu, Kenji Ino, Kyouhito Iida, Keiichi Yano, Kuni Ohtomo
    Radiological Physics and Technology 4 2 185 - 188 2011年07月 [査読無し][通常論文]
    Our aim in the present additional study was to investigate the absolute hippocampal volume in normal adults who were divided into eight groups according to their age and gender, because our previous study with voxel-based morphometry (VBM) was not able to show the absolute hippocampal volume. High-spatial-resolution T1-weighted images with 3.0 Tesla magnetic resonance scanners were obtained on 412 healthy adults who were divided into 8 groups, according to age and gender, for analysis of brain volume change focusing on hippocampal volume. Hippocampal regions of interest were obtained with WFU PickAtlas software. As a result, the present study revealed a significant difference bilaterally between the groups of females in their forties and those in their fifties. Because this result is the same as that of our previous study with VBM, it adds evidence to the hypothesis that menopause is associated with hippocampal volume reduction. However, the result between groups of males in their sixties and those in their seventies was inconsistent in both studies. In conclusion, the present study showed that reduction in the hippocampal volume over one decade was small compared to the standard deviation in each group. This study is useful for improving our understanding of the correlation between menopause and hippocampal volume reduction. © 2011 Japanese Society of Radiological Technology and Japan Society of Medical Physics.
  • Fumiko Kawakami-Mori, Harushi Mori
    Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 2 429 - 434 2011年03月 [査読無し][通常論文]
  • Masami Goto, Osamu Abe, Tosiaki Miyati, Sachiko Inano, Naoto Hayashi, Shigeki Aoki, Harushi Mori, Hiroyuki Kabasawa, Kenji Ino, Keiichi Yano, Kyouhito Iida, Kazuo Mima, Kuni Ohtomo
    JOURNAL OF MAGNETIC RESONANCE IMAGING 33 1 48 - 53 2011年01月 [査読無し][通常論文]
    Purpose: To clarify age-related structural changes specific to hippocampal volume by hierarchizing according to age, gender, and menopausal status. Many studies report the neuroprotective effects of estrogen and age-related brain volume changes; however, there are no studies regarding age-related change specific to hippocampal volume in terms of age, gender, and menopausal status. Materials and Methods: T1-weighted MR images were obtained in 412 healthy adults divided into eight groups according to age and gender, to analyze brain volume change focusing on hippocampal volume. Results: Voxel-based morphometry (VBM) revealed significantly smaller gray matter volume in the hippocampus bilaterally in females aged in their fifties (51 of 59 females were at menopause) compared with females in their forties (3 of 46 females were at menopause). No significant difference was found, however, between female groups in their fifties versus sixties, or sixties versus seventies; or between male groups in their forties versus fifties, fifties versus sixties, or sixties versus seventies. In addition, VBM revealed significant hippocampal volume reduction bilaterally in all postmenopausal women compared with all premenopausal women. Conclusion: The results of the current study suggest that the menopause may be associated with hippocampal volume reduction.
  • Mizuho Murakami, Harushi Mori, Akira Kunimatsu, Osamu Abe, Hirotaka Chikuda, Takashi Ono, Hiroyuki Kabasawa, Kazuyuki Uchiumi, Jiro Sato, Shiori Amemiya, Shuhei Komatsu, Kuni Ohtomo
    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 35 1 16 - 20 2011年01月 [査読無し][通常論文]
    Objective: Magnetic resonance imaging (MRI) is the most popular follow-up study for patients who have undergone spinal surgery. However, the image quality often becomes poor because of artifacts from metal implants and/or from failed fat suppression, which obscure diagnosis. Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) is a new fat suppression method that is less affected by inhomogeneity of the magnetic field. Here, we compared postsurgical spinal MRI with IDEAL versus chemical shift selective saturation (CHESS). Methods: For 35 patients who had spinal surgery, we examined T2-weighted fast spin-echo sagittal images of the spine with both IDEAL and CHESS. Two radiologists evaluated the degrees of fat suppression and spinal canal projection from 0 (least/worst) to 2 (most/best). Results: Fat suppression and spinal canal scores for IDEAL were statistically higher than those for CHESS (P < 0.05). Conclusions: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation is clinically useful for postoperative spinal MRI.
  • Takashi Ueta, Harushi Mori, Akira Kunimatsu, Takuhiro Yamaguchi, Yasuhiro Tamaki, Yasuo Yanagi
    Ophthalmology 118 2011年01月 [査読無し][通常論文]
  • Y. Nakata, N. Sato, T. Masumoto, H. Mori, H. Akai, H. Nobusawa, Y. Adachi, H. Oba, K. Ohtomo
    AMERICAN JOURNAL OF NEURORADIOLOGY 31 10 1944 - 1950 2010年11月 [査読無し][通常論文]
    BACKGROUND AND PURPOSE: MR imaging findings of LYH and pituitary adenomas are similar, but the therapeutic strategies are completely different. The purpose of this study was to evaluate seller and parasellar MR imaging findings in patients with both diseases, as well as characteristic clinical findings. MATERIALS AND METHODS: Clinical findings, including endocrinologic study and MR images of 20 patients with LYH and 22 patients with pituitary adenoma, were retrospectively reviewed. We evaluated the MR images in relation to the following: 1) the PPHI on T1-weighted images, 2) thickened stalk (>3.5 mm), 3) pituitary symmetry, 4) pituitary enhancement pattern, 5) a dural tail, and 6) parasellar signal intensity on T2- and T1-weighted images. RESULTS: Between patients with LYH and those with pituitary adenoma, a significant difference was identified for the number of patients with loss of PPHI, thickened stalk, pituitary symmetry, homogeneous enhancement, and parasellar dark signal intensity on T2-weighted images by statistical analysis (Fisher exact probability test, P < .05). Among them, only parasellar dark signal intensity on T2-weighted images had no false-positive cases. CONCLUSIONS: The parasellar T2 dark sign can be a specific finding used to distinguish pituitary adenoma from LYH.
  • Sachiko Inano, Daisuke Itoh, Hidemasa Takao, Naoto Hayashi, Harushi Mori, Akira Kunimatsu, Osamu Abe, Shigeki Aoki, Kuni Ohtomo
    CLINICAL IMAGING 34 5 332 - 336 2010年09月 [査読無し][通常論文]
    Purpose: The objective of this study was to examine the frequency of high signal intensity in the dural sinuses of normal subjects upon magnetic resonance (MR) angiography using 3.0-T scanners. Methods: A total of 748 consecutive healthy subjects underwent three-dimensional time-of-flight MR angiography at 3.0 T. Sixteen subjects were excluded. MR angiographic source images were retrospectively reviewed for the presence of high signal intensity in the inferior petrosal sinus, pterygoid sinus, or sigmoid sinus. Results: Of the 732 examinations, 10 (1.3%) showed high signal intensity in the dural sinuses (left inferior petrosal sinus, n=4; left pterygoid sinus, n=3; left sigmoid sinus, n=6). High signal intensity in the dural sinuses was observed only on the left side. The minimum diameter of the left brachiocephalic vein was significantly smaller in subjects with high signal intensity than in the control group. Conclusion: In our study with healthy subjects at 3.0 T, the frequency of high signal intensity in the dural sinuses is as low as 1.3%. Retrograde flow due to physiological stenosis of the left brachiocephalic vein may be one of the causes of this phenomenon. (C) 2010 Elsevier Inc. All rights reserved.
  • Kanako Kunishima, Masahiro Shin, Akira Kunimatsu, Shigeki Aoki, Hiroki Sasaki, Tomoyuki Koga, Daisuke Itoh, Harushi Mori, Osamu Abe, Kuni Ohtomo, Nobuhito Saito
    NEUROSURGERY 67 1 100 - 109 2010年07月 [査読無し][通常論文]
    BACKGROUND: The reported cumulative risk of post-angiographic obliteration (post-AO) hemorrhage from arteriovenous malformations (AVMs) following gamma knife radiosurgery (GKRS) over 10 years is 2.2%. OBJECTIVE: To identify the warning signs of post-AO hemorrhage by analyzing the characteristics of enhancement on contrast-enhanced MRI magnetic resonance imaging (MRI) of AVMs with post-AO hemorrhage. METHODS: We performed a retrospective analysis of 121 patients whose AVMs were angiographically obliterated within 5 years of GKRS without hemorrhage and who received at least 1 contrast-enhanced MRI after GKRS (group 1), and 7 patients who experienced post-AO hemorrhage (group 2). We analyzed the enhancement persistence ratio (the percentage of AVMs with persisting enhancement on contrast-enhanced T1-weighted image after obliteration) and the change in size of the enhanced region over time in each patient. RESULTS: The enhancement persistence ratio showed no significant difference between the 2 groups (89.4% vs 100% for groups 1 and 2, respectively; P = .401). While most cases in group 1 showed a tendency to decrease in size and gradually stabilize following GKRS, there were significantly more cases in group 2 with obvious increment of the enhanced regions within 1 year of angiographic obliteration compared with the previous measurement (4.96% vs 71.4% for groups 1 and 2, respectively; P < .0001). CONCLUSION: Our results suggest that AVMs that show an increase in the size of the enhanced region within 1 year of angiographic obliteration should be followed up with caution for post-AO hemorrhage. Persisting enhancement itself is not positively associated with subsequent hemorrhage.
  • Masaaki Hori, Harushi Mori, Shigeki Aoki, Osamu Abe, Tomohiko Masumoto, Satoshi Kunimatsu, Kuni Ohtomo, Hiroyuki Kabasawa, Nobuyuki Shiraga, Tsutomu Araki
    MAGNETIC RESONANCE IMAGING 28 4 594 - 598 2010年05月 [査読無し][通常論文]
    Object: Although three-dimensional (3D), high-spatial resolution susceptibility-weighted imaging (SWI) appears to be valuable in the evaluation of central nervous system gliomas, several evaluation methods are proposed in the literature. The purpose of this study was to evaluate the use of 3D SWI for grading intracranial gliomas with various analysis methods. Materials and Methods: Twenty-three patients suspected of having gliomas participated in this study. SWI was performed in addition to conventional MR sequences. In 15 cases, post-gadolinium enhanced SWI was also obtained. Imaging evaluation criteria were conventional grade, hypointensity ratio in the tumor-dominant structure of hypointensity on SWI (hemorrhage or vascular structure) and presence of abnormal enhancement surrounding the tumor. Results: Mean grading scores of conventional grade showed no statistically significant difference among WHO grades. Mean grading scores of hypointensity ratios in the tumor were higher for WHO Grades 3 and 4 than for lower grade tumors (P=.05, Mann Whitney U test). Hemorrhagic foci were more frequently seen in the higher grade tumor. Post-contrast susceptibility-weighted images of five of 11 WHO Grade 3 and 4 cases showed bright enhancement surrounding the tumor, suggesting a breakdown of the blood brain barrier. Conclusions: SWI at 3 T may be a useful method to analyze the structural characteristics of gliomas and to evaluate pathology in vivo. Assessment of hypointensity ratios in the glioma was the most preferable method in grading glioma. However, more studies, specifically concerning a suitable method for image analysis, are needed to establish SWI at 3 T as a useful tool in clinical routine. (C) 2010 Elsevier Inc. All rights reserved.
  • Harushi Mori
    Brain and Nerve 62 5 501 - 509 2010年05月 [査読無し][通常論文]
    Here, we review of the efficacy of radioimaging method in the diagnosis of the spinal cord and spine disorders. The simplest solution for a successful diagnosis is to scan wide field in each image. Nothing will start unless one recognizes the imaging findings. Analysis based on the MECE principle, mutually exclusive and collectively exhaustive, is performed in four ways, that is deductive, fractionation, longitudinal and priority methods. Because purpose determines the means, structual constructivism suggests that one should employ the appropriate method depending on the situation (interest-correlative approach). The practical conventional procedure to attain a diagnosis is as follows. First identify the location of the lesion by using MRI or other modalities. The location of the lesion shorten the list of differential diagnosis. Second, obtain maximum information on the characteristics of the lesion in order to speculate the pathology. Third, look for any associated findings such as tortuous vasculature around the spinal cord. Fourth, refer to all the available information for example, chief complaint, clinical history, previous history, family history, physical findings, physiological findings, laboratory data, previous images, other modalities and so on. And finally, one should consult with the attending physician and colleagues when in doubt. However, because rationality (mathematical expectation: posterior probability or positive predictive value with positive findings), predicted utility, and emotions affect human beings while making decisions, it seems impossible to completely avoid oversights and misdiagnosis.
  • Harushi Mori
    Japanese Journal of Clinical Radiology 55 279 - 288 2010年02月 [査読無し][通常論文]
    An approach for easy diagnosis of intradural disorders is reviewed. First of all, we must specify the location of the intradural lesion on MRI or other modalities. The location constrains the list of differential diagnosis. Second, we should detail the property of the lesion to speculate the pathology. Third, we should search any associated findings such as tortuous vasculature around the spinal cord. Forth, we should refer all information possible. And finally, we should consult with colleague.
  • Kanako Sato, Shigeki Aoki, Nobue K. Iwata, Osamu Abe, Harushi Mori, Kuni Ohtomo
    Brain and Nerve 61 11 1259 - 1268 2009年11月 [査読無し][通常論文]
    Classic magnetic resonance imaging (MRI) findings in patients with amyotrophic lateral sclerosis (ALS) are subtle, but some findings have been reported such as signal changes in the primary motor cortex and the corticospinal tract (CST). Only a few reports have discussed MRI findings of ALS with dementia (ALS-D), in which frontotemporal atrophy and hyperintensity in subcortical white matter of bilateral temporal tips have been reported. Recent development of diffusion tensor imaging (DTI) techniques allows us to extract specific white matter tracts and to analyze them quantitatively, i.e. we can visualize the CST and can also measure its integrity using DTI parameters such as fractional anisotropy (FA) or apparent diffusion coefficient (ADC). In patients with ALS, general decrease in FA and increase in ADC in the CST have been reported. In patients with ALS-D, several authors detected decrease in fractional anisotropy in the corpus callosum, the thalamus, frontal/parietal/ temporal, the cingulate gyrus, and the uncinate fasciculus in addition to the CST. Voxel based morphometry or statistical analysis of imaging are the newly developed methods which enable to make objective and reliable imaging analysis based on automated procedure using standardized database. We also presented several researches using these techniques. In this article, we reviewed classic imaging findings and recent development of MRI including DTI and statistical imaging analysis in patients with ALS/ALS-D.
  • Kanako Kunishima, Harushi Mori, Daisuke Itoh, Shigeki Aoki, Hiroyuki Kabasawa, Tomoyuki Koga, Keisuke Maruyama, Tomohiko Masumoto, Osamu Abe, Kuni Ohtomo
    JOURNAL OF NEUROSURGERY 110 3 492 - 499 2009年03月 [査読無し][通常論文]
    Object. Although conventional catheter angiography is commonly used in the evaluation of intracranial arteriovenous malformations (AVMs), less invasive tools are more suitable for screening or follow-up. Older MR angiography techniques cannot provide high enough temporal and spatial resolution for assessing AVMs. Three-tesla time-resolved imaging of contrast kinetics (TRICKS)-a time-resolved, contrast-enhanced 3D MR angiography technique-achieves subsecond time resolution without sacrificing spatial resolution. The purpose of this study was to assess the accuracy of TRICKS at 3 T in the evaluation of AVMs. Methods. Between November 2006 and November 2007, 31 patients who were known to have AVMs underwent evaluation in a 3-T unit with the TRICKS technique. The TRICKS images were then evaluated independently by 2 radiologists for nidus detection, early venous filling detection, and Spetzler-Martin classification, and these results were compared, with the results of catheter angiography. Results. Time-resolved imaging of contrast kinetics achieved 96% sensitivity and 100% specificity both in nidus detection and early venous filling detection. The Spetzler-Martin grades also showed excellent correlation with catheter angiography findings (kappa = 0.89). Conclusions. Although this is a preliminary study, the authors' results indicate that time-resolved contrast-enhanced 3D MR angiography at 3 T is a good tool to assess AVMs, and has the potential to replace catheter angiography in screening or follow-up examinations of patients with AVMs. (DOI: 10.3171/2008.7.JNS08173)
  • Takeharu Yoshikawa, Shigeki Aoki, Osamu Abe, Naoto Hayashi, Yoshitaka Masutani, Tomohiko Masumoto, Harushi Mori, Yoshiroh Satake, Kuni Ohtomo
    RADIATION MEDICINE 26 8 481 - 487 2008年10月 [査読有り][通常論文]
    Purpose. The aim of the study was to estimate the effect of distortion correction with correspondence to numbers of encoding directions to acquire diffusion tensor imaging (DTI) of improved quality. Materials and methods. Ten volunteers underwent DTI of the head using echo planar imaging with 6, 13, 27, and 55 encoding directions. Fractional anisotropy (FA) maps and apparent diffusion coefficient (ADC) maps were created before and after distortion correction. Regions of interest were placed in the corpus callosum on each map, and standard deviations of FA and ADC were calculated. FA maps were also evaluated visually by experienced neuroradiologists. Results. Dispersion of standard deviations tended to be reduced after distortion correction, with significant differences found in FA maps with 6 encoding directions, ADC maps with 6 directions, and ADC maps with 13 directions (P < 0.001, P < 0.005, and P < 0.05, respectively). Visual image quality was improved after distortion correction (P < 0.01 for all of the visual comparisons). Conclusion. Distortion correction is effective in providing DTI of enhanced quality, notwithstanding the number of encoding directions.
  • Takeharu Yoshikawa, Shigeki Aoki, Osamu Abe, Naoto Hayashi, Yoshitaka Masutani, Tomohiko Masumoto, Harushi Mori, Yoshiroh Satake, Kuni Ohtomo
    Radiation Medicine - Medical Imaging and Radiation Oncology 26 8 481 - 487 2008年10月 [査読無し][通常論文]
    Purpose. The aim of the study was to estimate the effect of distortion correction with correspondence to numbers of encoding directions to acquire diffusion tensor imaging (DTI) of improved quality. Materials and methods. Ten volunteers underwent DTI of the head using echo planar imaging with 6, 13, 27, and 55 encoding directions. Fractional anisotropy (FA) maps and apparent diffusion coefficient (ADC) maps were created before and after distortion correction. Regions of interest were placed in the corpus callosum on each map, and standard deviations of FA and ADC were calculated. FA maps were also evaluated visually by experienced neuroradiologists. Results. Dispersion of standard deviations tended to be reduced after distortion correction, with significant differences found in FA maps with 6 encoding directions, ADC maps with 6 directions, and ADC maps with 13 directions (P < 0.001, P < 0.005, and P < 0.05, respectively). Visual image quality was improved after distortion correction (P < 0.01 for all of the visual comparisons). Conclusion. Distortion correction is effective in providing DTI of enhanced quality, notwithstanding the number of encoding directions. © 2008 Japan Radiological Society.
  • Mio Sakai, Shigeki Aoki, Yusuke Inoue, Ryuichi Ashida, Haruyasu Yamada, Shigeru Kiryu, Sachiko Inano, Harushi Mori, Yoshitaka Masutani, Osamu Abe, Kuni Ohtomo, Hironobu Nakamura
    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 32 5 822 - 824 2008年09月 [査読無し][通常論文]
    We report a patient with linear scleroderma en coup de sabre without neurological symptoms despite the presence of large white matter lesions. The patient underwent 3.0-T magnetic resonance (MR) examinations including diffusion tensor imaging, time-resolved contrast-enhanced MR angiography, susceptibility-weighted imaging, and proton MR spectroscopy. These imaging findings suggested increased vascular permeability and microbleeding without abnormalities of metabolites. Our observation is consistent with vasculopathy and may be helpful in the proper diagnosis and treatment of linear scleroderma en coup de sabre.
  • Masami Goto, Yuuichi Suzuki, Osamu Abe, Naoto Hayashi, Shigeki Aoki, Harushi Mori, Tomohiko Masumoto, Yasushi Watanabe, Yoshirou Satake, Kenji Ino, Keiichi Yano, Kyouhito Iida, Kazuo Mima, Kuni Ohtomo
    Radiological physics and technology 1 2 196 - 200 2008年07月 [査読無し][通常論文]
    A voxel-based specific regional analysis system for Alzheimer's disease (VSRAD) was used for quantitative analysis of parahippocampal atropy with 1.5-tesla (T) MRI in a voxel-wise manner. The analysis of images acquired under a different imaging condition provides an error factor that has a calculated value. Clinical application of 3T-MRI is necessary for establishing a normal data base (N-DB) specific for 3T-MRI data, which permits appropriate application of VSRAD. We established an N-DB specific for 3T-MRI for use in VSRAD. The "Z-score of the parahippocampal gyrus" was 0.79 +/- 0.32, and the N-DB of each age group did not have a big deflection when we analyzed a group of physically unimpaired persons in an N-DB specific for 3T-MRI. Therefore, we were able to confirm the validity of the customized N-DB. The "Z-score of the parahippocampal gyrus" was 1.62 +/- 0.47 for the N-DB of VSRAD. The numerical value was high for the group of physically unimpaired persons.
  • Harushi Mori
    Clinical Neurology 48 11 945 - 946 2008年 [査読無し][通常論文]
    Diffusion tensor imaging of magnetic resonance imaging, including diffusion tensor tractography, is a unique tool to visualize and segment the white matter pathways in vivo and one can evaluate the segmented trace quantitatively. Three dimensional visualization of the white matter fibers, such as corticospinal (pyramidal) tracts, with relationship to brain lesions (infarcts, vascular malformations and brain tumors) is extremely helpful for stereotactic radiosurgery, preoperative evaluation and intraoperative navigation. Quantitative measurement of the tract is a very sensitive method to detect differences in the tract in neurodegenerative/neurocognitive/psychiatric patients such as amyotrophic lateral sclerosis, schizophrenia and Alzheimer diseases. Importance of this tool will become more significant in clinical and neuroscience fields in the future.
  • Yoshinori Fujishiro, Kazunari Nakao, Kenta Watanabe, Yasuhiro Ebihara, Naoki Nakamura, Harushi Mori, Naoto Hayash, Takahiro Asakage
    ACTA OTO-LARYNGOLOGICA 127 151 - 156 2007年12月 [査読無し][通常論文]
    Conclusion. This superselective intra-arterial intervention technique enabled us to administer a higher dose of cisplatinum to the local lesion with a lower incidence of adverse issues by use of neutralizer, compared with the conventional methods. Objective. A wide variety of modalities, including surgery, radiotherapy, and chemotherapy, alone or in combination, have been reported for the treatment of maxillary sinus cancer. However, there is still much controversy with regard to the optimum treatment to obtain better local control and acceptable preservation of shape and function. Since 2001, we have performed superselective intra-arterial infusion chemotherapy in combination with radiotherapy and surgery aiming at a higher local control rate. Patients and methods. This was a review of prospective collected data. The therapeutic design consisted of weekly intra-arterial infusion of high dose CDDP with concomitant radiotherapy and planned surgery performed during chemo-radiation therapy. From June 2001 to January 2004, 14 patients with squamous cell carcinoma of maxillary sinus underwent this treatment procedure at the University of Tokyo Hospital. Results. The local response rate with this combined therapy was 85.7%. Overall survival rates at 1 and 2 years were 78.6% and 56.2%, respectively, with median follow-up of 25.5 months.
  • H. Mori, A. Yagishita, T. Takeda, T. Mizutani
    AMERICAN JOURNAL OF NEURORADIOLOGY 28 8 1511 - 1516 2007年09月 [査読無し][通常論文]
    BACKGROUND AND PURPOSE: Our aim was to clarify imaging findings of amyotrophic lateral sclerosis with dementia (ALSD). MATERIALS AND METHODS: T2-weighted MR images (T2WI) of 3 patients with ALSD (2 men, 1 woman; 58-71 years of age) and 21 patients with ALS without dementia (12 men, 9 women; 46-74 years of age) were examined for frontotemporal lobar atrophy and signal-intensity alterations in the white matter of the anterior temporal lobes, corticospinal tracts (CST), and precentral gyri and in precentral cortices. The brain of one of the patients with ALSD was examined at autopsy. RESULTS: All patients with ALSD showed bilateral frontotemporal atrophy mostly with temporal lobe dominance. In the ALSD group, T2WI demonstrated hyperintensity in the subcortical white matter on the medial side of the anterior temporal lobes, whereas in the group without dementia, none showed this imaging finding. MR images demonstrated no abnormal signal-intensity changes in CST in the internal capsule or the brain stem in the ALSD group. In the group without dementia, 6 patients (28.6%) showed this imaging finding, In neuropathologic examinations of the brain of 1 patient with ALSD, myelin-stained sections of the brain demonstrated loss of myelin in the subcortical white matter on the medial side of the anterior temporal white matter. CONCLUSIONS: A symmetric pattern of frontotemporal atrophy and anteromedial subcortical hyperin-tensities in the temporal lobes on T2WI could be characteristic of ALSD.
  • Harushi Mori, Shigeki Aoki, Kuni Ohtomo
    Magnetic Resonance in Medical Sciences 6 3 183 - 184 2007年 [査読無し][通常論文]
  • Makoto Watanabe, Shigeki Aoki, Yoshitaka Masutani, Osamu Abe, Naoto Hayashi, Tomohiko Masumoto, Harushi Mori, Hiroyuki Kabasawa, Kuni Ohtomo
    Radiation medicine 24 9 605 - 9 2006年11月 [査読無し][通常論文]
    PURPOSE: The aim of this study was to develop ex vivo diffusion tensor (DT) flexible phantoms. MATERIALS AND METHODS: Materials were bundles of textile threads of cotton, monofilament nylon, rayon, and polyester bunched with spiral wrapping bands and immersed in water. DT images were acquired on a 1.5-Tesla clinical magnetic resonance scanner using echo planar imaging sequences with 15 motion probing gradient directions. DT tractography with seeding and a line-tracking method was carried out by software originally developed on a PC-based workstation. RESULTS: We observed relatively high fractional anisotropy on the polyester phantom and were able to reconstruct tractography. Straight tracts along the bundle were displayed when it was arranged linearly. It was easy to bend arcuately or bifurcate at one end; and tracts followed the course of the bundle, whether it was curved or branched and had good agreement with direct visual observation. Tractography with the other fibers was unsuccessful. CONCLUSION: The polyester phantom revealed a diffusion anisotropic structure according to its shape and would be utilizable repeatedly under the same conditions, differently from living central neuronal system. It would be useful to validate DT sequences and to optimize an algorithm or parameters of DT tractography software. Additionally, the flexibility of the phantom would enable us to model human axonal projections.
  • Takeharu Yoshikawa, Naoto Hayashi, Shinichi Yamamoto, Yasuhito Tajiri, Naoki Yoshioka, Tomohiko Masumoto, Harushi Mori, Osamu Abe, Shigeki Aoki, Kuni Ohtomo
    RADIOGRAPHICS 26 S133 - U136 2006年10月 [査読無し][通常論文]
    Brachial plexus injury (BPI) is a severe neurologic injury that causes functional impairment of the affected upper limb. Imaging studies play an essential role in differentiating between preganglionic and postganglionic injuries, a distinction that is crucial for optimal treatment planning. Findings at standard myelography, computed tomographic (CT) myelography, and conventional magnetic resonance (MR) imaging help determine the location and severity of injuries. MR imaging sometimes demonstrates signal intensity changes in the spinal cord, and enhancement of nerve roots and paraspinal muscles at MR imaging indicates the presence of root avulsion injuries. New techniques including MR myelography, diffusion-weighted neurography, and Bezier surface reformation can also be useful in the evaluation and management of BPI. MR myelography with state-of-the-art technology yields remarkably high-quality images, although it cannot replace CT myelography entirely. Diffusion-weighted neurography is a cutting-edge technique for visualizing postganglionic nerve roots. Bezier surface reformation allows the depiction of entire intradural nerve roots on a single image. CT myelography appears to be the preferred initial imaging modality, with standard myelography and contrast material - enhanced MR imaging being recommended as additional studies. Work-up will vary depending on the equipment used, the management policy of peripheral nerve surgeons, and, most important, the individual patient.
  • Daisuke Itoh, Shigeki Aoki, Keisuke Maruyama, Yoshitaka Masutani, Harushi Mori, Tomohiko Masumoto, Osamu Abe, Naoto Hayashi, Toshiyuki Okubo, Kuni Ohtomo
    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 30 4 618 - 623 2006年07月 [査読無し][通常論文]
    Objective: To visualize the corticospinal tract (CST) in patients with arteriovenous malformations (AVMs) by using diffusion tensor tractography (DTT) and to confirm the clinical reliability of DTT in patients with AVMs. Methods: We performed DTT in 24 patients who had their AVMs near the CST. Tracts and AVMs were shown simultaneously, providing information on their spatial relationships. We also counted numbers of voxels in the DTT-CST at the level of the AVM. Results: DTT was visualized in 23 patients. In all 9 patients with hemiparesis, their DTT-CSTs were involved in the AVM or its surrounding lesion. Their volume of DTT-CST at the affected side was significantly decreased when compared with the contralateral side (P= 0.0469). All 14 patients whose DTT-CSTs were free from lesion had no hemiparesis. Conclusions: DTT was safe and clinically applicable in patients with AVMs. DTT is recommended when an AVM is located near the corticospinal tract.
  • M. Watanabe, Y. Masutani, S. Aoki, K. Kamada, O. Abe, N. Hayashi, H. Mori, K. Ohtomo
    International Journal of Computer Assisted Radiology and Surgery 1 7 487  2006年 [査読有り][通常論文]
  • Makoto Watanabe, Yoshitaka Masutani, Shigeki Aoki, Harushi Mori, Osamu Abe, Naoto Hayashi, Tomohiko Masumoto, Haruyasu Yamada, Takeharu Yoshikawa, Hiroyuki Kabasawa, Kuni Ohtomo
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 65 4 449 - 51 2005年10月 [査読無し][通常論文]
    No literature has reported on in-vitro diffusion tensor tractography, although it is a useful method to visualize neuronal fiber projections in the living human brain. We applied this technique to phantoms of asparagus stems and bundled polyester yarn, and obtained tractography with high-quality images. On the asparagus stem phantom, straight tracts along the axis were displayed. On the polyester phantom, these tracts followed the course of the bundle whether it was straight or curved. These phantoms are useful for in-vitro evaluation of diffusion tensor tractography.
  • Shigeki Aoki, Nobue K Iwata, Yoshitaka Masutani, Mariko Yoshida, Osamu Abe, Yoshikazu Ugawa, Tomohiko Masumoto, Harushi Mori, Naoto Hayashi, Hiroyuki Kabasawa, Shin Kwak, Seizou Takahashi, Shoji Tsuji, Kuni Ohtomo
    Radiation medicine 23 3 195 - 9 2005年05月 [査読無し][通常論文]
    PURPOSE: Diffusion tensor imaging can evaluate the cerebral white matter quantitatively using fractional anisotropy (FA) and also can extract a certain tract by tractography, but these two have been used separately and not combined. The purpose of this study was to assess the clinical feasibility of ROI analysis using diffusion tensor tractography (DTT) in patients with amyotrophic lateral sclerosis (ALS). MATERIALS AND METHODS: Sixteen patients with ALS (9 limb-onset type, 7 bulbar-onset type) and nine age-matched volunteers were studied. DTT of the corticobulbar tract (DTT-CBT) and corticospinal tract (DTT-CST) were visualized by free software (dTV/VOLUME-ONE). Regions-of-interest (ROIs) were semi-automatically placed on the tracts defined by DTT methods, and FA values within the ROIs were measured. RESULTS: Mean FA values of ALS patients in the ROIs along the DTT-CST (bulbar-onset: 0.574, limb-onset: 0.594) were significantly lower than those of controls (DTT-CST: 0.629) (p<0.05). The mean FA of DTT-CBT of the bulbar-onset type (0.509) was significantly lower than that of the limb-onset type (0.558) and that of volunteers (0.561). CONCLUSION: DTT could segmentate certain white matter tracts and evaluate them quantitatively. It could depict the subtle changes between subtypes of ALS as well as the changes between the patients and volunteers.
  • H Mori, T Fijishiro, N Hayashi, Y Masutani, S Aoki, K Ohtomo, M Aihara, M Wakakura
    AMERICAN JOURNAL OF ROENTGENOLOGY 184 3 S4 - S6 2005年03月 [査読無し][通常論文]
  • H Akai, H Mori, S Aoki, Y Masutani, N Kawahara, J Shibahara, K Ohtomo
    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 29 1 127 - 129 2005年01月 [査読無し][通常論文]
    In previous reports, tracts obtained by diffusion tensor (DT) fiber tracking were terminated or deviated by the brain tumors or surrounding edema. There has been no report showing diffusion tensor tractography penetrating through the tumor. A case of glioma is reported, whose DT fiber tract passing through the tumor was observed by changing the threshold of fractional anisotropy.
  • Y Masutani, S Aoki, O Abe, M Yoshida, H Yamada, H Mori, K Ino, K Ohtomo
    ADVANCES IN VISUAL COMPUTING, PROCEEDINGS 3804 84 - 91 2005年 [査読無し][通常論文]
    The diffusion tensor tractography has drawbacks such as low objectivity by interactive ROI setting and fiber-crossing. For coping with such problems, we are constructing a statistical atlas of white matter fiber tracts, in which probability density maps of tract structures are stored with diffusion tensor parameters on spatially normalized brain data. In building the atlas, our fiber tract modeling method plays a key role, which is based on a novel approach of vector/tensor field reconstruction avoiding fiber-crossings. In this abstract, we describe the modeling method, our statistical atlas, and the preliminary results.
  • H Mori, S Aoki, O Abe, N Hayashi, Y Masutani, K Ohtomo, S Oya, A Morita
    ACTA RADIOLOGICA 45 8 886 - 886 2004年12月 [査読無し][通常論文]
  • H. Mori, S. Aoki, O. Abe, N. Hayashi, Y. Masutani, K. Ohtomo, S. Oya, A. Morita
    Acta Radiologica 45 8 779  2004年12月 [査読無し][通常論文]
  • H Mori, S Aoki, O Abe, N Hayashi, Y Masutani, K Ohtomo, S Oya, A Morita
    ACTA RADIOLOGICA 45 7 778 - 781 2004年11月 [査読無し][通常論文]
    Diffusion-tensor imaging (DTI), a unique magnetic resonance technique for analysis of diffusion-anisotropy of the brain, can identify subtle white matter changes in vivo. To investigate changes of truncated neurofibers, DTI was conducted prior to and following functional hemispherectomy in a female infant for refractory epilepsy associated with hemimegalencephaly. Anisotropy of the amputated pyramidal tract decreased relative to the unaffected side after surgery, which reflects secondary degeneration in neurofibers. In DTI applied to infants, differentiation between developmental changes and changes associated with the current phenomenon must be evaluated cautiously. Standardization of diffusion-tensor analysis of developmental change is desirable.
  • 脳のMRI診断338症例 脳腫瘍
    林 直人, 森 墾, 吉川 健啓, 前田 正幸, 中田 安浩, 和田 昭彦, 加藤 伸之, 大久保 敏之
    画像診断 別冊 新版よくわかる脳MRI 38 - 105 (株)学研メディカル秀潤社 2004年10月
  • J Shibahara, T Todo, A Morita, H Mori, S Aoki, M Fukayama
    ACTA NEUROPATHOLOGICA 108 4 337 - 340 2004年10月 [査読無し][通常論文]
    We present here an unusual case of papillary neuroepithelial tumor of the pineal region. The patient was a 29-year-old female who presented with headaches. A computed tomography scan revealed a tumorous lesion at the pineal region and hydrocephalus. The resected tumor was composed of columnar and cuboidal cells showing characteristics of papillary growth. The tumor cells exhibited diffuse and intense immunoreactivity to cytokeratins and neural cell adhesion molecule. The tumor expressed abundant levels of transthyretin (prealbumin) and appeared ependymal in nature, with numerous microlumens delineated by punctate and ring-like patterns in epithelial membrane antigen staining. Reactivity to synaptophysin and glial fibrillary acidic protein was observed only in the infiltrated non-neoplastic pineal parenchyma. These histological characteristics matched the description of the recently reported papillary tumor of the pineal region thought to originate from the specialized ependyma of the subcommissural organ (SCO). Transthyretin expression of the present case further supports the likelihood of SCO origin, as transthyretin is one of the proteins presumed to be secreted by human SCO.
  • O Abe, H Yamada, Y Masutani, S Aoki, A Kunimatsu, H Yamasue, R Fukuda, K Kasai, N Hayashi, T Masumoto, H Mori, T Soma, K Ohtomo
    NMR IN BIOMEDICINE 17 6 411 - 416 2004年10月 [査読無し][通常論文]
    The purpose of this study is to investigate whether the diffusional anisotropy of water molecules is disrupted in the pyramidal and extra-pyramidal regions in patients with amyotrophic lateral sclerosis (ALS). We studied seven patients with probable ALS (four women, mean age+/-SD, 57.3+/-6.2 years old) according to the criteria of the World Federation of Neurology. A control group consisted of 11 age- and sex-matched volunteers (six women, 57.1+/- 4.5) without disorders affecting the central nervous system. Voxel-based diffusion tensor analysis was made with statistical parametric mapping (SPM99). We also created the normalized corticospinal tractography from the diffusion tensor data. The significant fractional anisotropy (FA) decrease in the ALS group was found in the right frontal subgyral white matter and left frontal precentral white matter. These clusters with significant FA decrease corresponded well to the average group map of the corticospinal tract in a standard reference frame. These results suggested that the combination of voxel-based diffusion tensor analysis and diffusion tensor tractography might help determine the location of the affected neuronal tissues among ALS patients in a non-invasive manner. Copyright (C) 2004 John Wiley Sons, Ltd.
  • O Abe, H Mori, S Aoki, A Kunimatsu, N Hayashi, T Masumoto, H Yamada, Y Masutani, H Kabasawa, K Ohtomo
    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 28 5 654 - 660 2004年09月 [査読無し][通常論文]
    Objective: To evaluate diffusion tensor imaging (DTI) based on periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) compared with DTI based on single-shot echo planar imaging (EPI). Methods: Diffusion tensor data were acquired with PROPELLER (PROPELLER-DTI, 3 NEX), EPI (EPI-DT12,16 NEX) with the same acquisition time (11.4 minutes) and with EPI (EPI-DTI I, number of excitations = 4) with a shorter acquisition time (2.8 minutes). Regions of interest were set in the genu and splenium of the corpus callosurn, as determined on T2-weighted fast spin echo images and fractional anisotropy (FA) maps, separately. Two neuroradiologists visually evaluated image distortion and quality in the supra- and infratentorial structures. Results: in the genu, standard deviation determined by respective FA maps was decreased in order of PROPELLER-DTI, EPI-DTI 1, and EPI-DT12. Both EPI-DTI sequences were quantitatively superior in the splenium, but PROPELLER-DTI was less distorted. Conclusion: Periodically rotated overlapping parallel lines with enhanced reconstruction-DTI could become a complementary tool when qualitatively evaluating seriously distorted structures.
  • O Abe, Y Masutani, S Aoki, H Yamasue, H Yamada, K Kasai, H Mori, N Hayashi, T Masumoto, K Ohtomo
    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 28 4 533 - 539 2004年07月 [査読無し][通常論文]
    Objective: To evaluate the crossing fiber trajectory through the corpus callosum using distortion-corrected diffusion tensor tractography in the human brain. Methods: After correcting distortion associated with large-diffusion gradients, T2-weighted echo planar images (EPIs) acquired from 10 right-handed healthy men were coregistered into T2-weighted fast spin echo images using linear through sixth-order nonlinear, 3-dimensional, polynomial warping functions. The optimal transformation parameters were also applied to the distortion-corrected diffusion-weighted EPIs. Diffusion tensor tractography through the corpus callosum was reconstructed, employing the "1 or 2 regions of interest" method. Results: Compared with the lines through the genu, those through the rostrum ran more inferiorly and seemed to enter the orbital gyrus. Those lines entering posterior temporal white matter (tapetum) crossed through the ventral portion of the splenium and were clearly distinguished from lines that reached parieto-occipital white matter (forceps major). Conclusion: Diffusion tensor tractography is a feasible noninvasive tool to evaluate commissural fiber trajectory.
  • H. Mori, Y. Masutani, O. Abe, S. Aoki, N. Hayashi, T. Masumoto, T. Yoshikawa, H. Yamada, K. Ohtomo
    Rivista di Neuroradiologia 17 2 135 - 144 2004年04月 [査読無し][通常論文]
    Diffusion tensor imaging (DTI) is a magnetic resonance (MR) technique used to analyze diffusion anisotropy of the central nervous system (CNS) and can demonstrate subtle white matter anatomy. In particular, tractography is expected to be a unique, non-invasive tool to provide more pertinent insights into brain structure and orientation not accessible with conventional MRI. Data collection was performed in a normal volunteer on a 1.5-T MRI system using several techniques including six axis single-shot echo planar imaging (EPI), over six axis EPI, and periodically rotated overlapping parallel lines with enhanced reconstruction techniques. Tractography was generated by a continuous tracking method with our original software, Volume-One (for viewing volumetric image data) and VizDT-II (for analysis of DTI data). Using these data, estimated tracts were generated in arcuate fibers of cerebrum, cingulum, superior longitudinal fasciculus, uncinate fasciculus, inferior longitudinal fasciculus, corpus callosum, fornix, anterior thalamic radiation, central thalamic radiation, thalamo-parietal fibers, optic radiation, superior cerebellar peduncle, middle cerebellar peduncle, inferior cerebellar peduncle and intrinsic commissure paths of the hipoccampous. DTI including tractography allows differentiation between complex white matter tracts. The information regarding the detailed relationship may be useful for diagnosis of the location and extent of brain lesions, and preoperative planning.
  • H. Mori, S. Aoki, O. Abe, N. Hayashi, T. Masumoto, T. Yoshikawa, K. Ohtomo, M. Hirakawa, Y. Ugawa
    Rivista di Neuroradiologia 17 1 13 - 16 2004年02月 [査読無し][通常論文]
    Periodically Rotated Overlapping Parallel Lines with Enhanced Reconstruction (PROPELLER) is one of the newer magnetic resonance imaging (MRI) methods developed to correct motion artifacts. PROPELLER uses a radial scan variation of the fast spin-echo sequence and spatial inconsistencies to be corrected using self navigation and an averaging effect for low spatial frequencies. We report and assess the imaging findings in a restless patient with Creutzfeldt-Jakob disease with a point mutation at codon 180 in prion protein DNA using PROPELLER diffusion-weighted MRI.
  • H. Mori, S. Aoki, K. Ohtomo
    Rivista di Neuroradiologia 17 5 659 - 660 2004年 [査読無し][通常論文]
    T2-weighted MR imaging (T2WI) in patients presenting with variant Creutzfeldt-Jakob disease (vCJD) can demonstrate high signal intensity lesions in both pulvinars and/or medial side of thalami (the pulvinar sign) at a high rate. Nevertheless, since patients with dementia are frequently uncooperative and restless, the T2WI sequence may often fail. This article presents a clinically effective case involving application of PROPELLER MRI with correction of reduced motion artifacts to exclude the pulvinar sign.
  • Masami Goto, Shigeki Aoki, Naoto Hayashi, Harushi Mori, Yasushi Watanabe, Kenji Ino, Yoshirou Satake, Katuji Nishida, Haruo Sato, Kyouhito Iida, Kazuo Mima, Kuni Ohtomo
    Nippon Hoshasen Gijutsu Gakkai zasshi 60 1519 - 1525 2004年01月 [査読無し][通常論文]
    PURPOSE: To evaluate the ability of periodically rotated overlapping parallel lines with enhanced reconstruction diffusion-weighted imaging (PROPELLER DWI) to distinguish between vessel occlusion and slow flow. MATERIALS AND METHODS: Using a flow phantom with various velocities (1.37 to 11.1 cm/s), the signal-intensity ratios of the phantom, with the intensity of no flow as baseline, were measured using the following imaging sequences: PROPELLER DWI, spin-echo T1-weighted imaging (SE T1WI), fast-spin-echo T2-weighted imaging (FSE T2WI), two-dimensional phase-contrast imaging (2D PC), and two-dimensional time-of-flight imaging (2D TOF). The b-factor of PROPELLER DWI was varied from 0 to 1000 s/mm(2). The velocity encoding of 2D PC was varied from 2 to 30 cm/s. RESULTS: At the lowest flow velocity (1.37 cm/s) , the signal-intensity ratio was 0.0075 for PROPELLER DWI (b-factor=1000 s/mm(2)), 1.8 for SE T1WI, 0.67 for FSE T2WI, 11 for 2D PC (velocity encoding=2 cm/s), and 1.4 for 2D TOF. The signal-intensity ratio was smallest for PROPELLER DWI, even when the reciprocals of the signal-intensity ratio of 2D PC or 2D TOF were considered. CONCLUSION: The results indicate that PROPELLER DWI provides the best signal intensity-ratio between vessel occlusion and slow flow. Although DWI with single-shot echo-planar imaging (EPI) or multi-shot EPI may have similarly high sensitivity for slow flow, these sequences do not have high spatial resolution or robustness to susceptibility artifacts. PROPELLER DWI would be a better choice for distinguishing between occluded and low-velocity arteries in the skull base or parasellar regions.
  • Masami Goto, Shigeki Aoki, Naoto Hayashi, Harushi Mori, Yasushi Watanabe, Kenji Ino, Yoshirou Satake, Katuji Nishida, Haruo Sato, Kyouhito Iida, Kazuo Mima, Kuni Ohtomo
    Nippon Hoshasen Gijutsu Gakkai zasshi 60 1585 - 1591 2004年01月 [査読無し][通常論文]
    As the PROPELLER sequence is a combination of the radial scan and fast-spin-echo (FSE) sequence, it can be considered an FSE sequence with a motion correlation. However, there are some differences between PROPELLER and FSE owing to differences in k-space trajectory. We clarified the imaging characteristics of PROPELLER T2-weighted imaging (T2WI) for different parameters in comparison with usual FSE T2WI. When the same parameters were used, PROPELLER T2WI showed a higher signal-to-noise ratio (SNR) and lower spatial resolution than usual FSE. Effective echo time (TE) changed with different echo train lengths (ETL) or different bandwidths on PROPELLER, and imaging contrast changed accordingly to be more effective.
  • Akira Kunimatsu, Shigeki Aoki, Yoshitaka Masutani, Osamu Abe, Naoto Hayashi, Harushi Mori, Tomohiko Masumoto, Kuni Ohtomo
    Magnetic Resonance in Medical Sciences 3 1 11 - 17 2004年 [査読無し][通常論文]
    Purpose: In order to ensure that three-dimensional diffusion tensor tractography (3D-DTT) of the corticospinal tract (CST), is performed accurately and efficiently, we set out to find the optimal lower threshold of fractional anisotropy (FA) below which tract elongation is terminated (trackability threshold). Methods: Thirteen patients with acute or early subacute ischemic stroke causing motor deficits were enrolled in this study. We performed 3D-DTT of the CST with diffusion tensor MR (magnetic resonance) imaging. We segmented the CST and established a cross-section of the CST in a transaxial plane as a region of interest. Thus, we selectively measured the FA values of the right and left corticospinal tracts at the level of the cerebral peduncle, the posterior limb of the internal capsule, and the centrum semiovale. The FA values of the CST were also measured on the affected side at the level where the clinically relevant infarction was present in isotropic diffusion-weighted imaging. Results: 3D-DTT allowed us to selectively measure the FA values of the CST. Among the 267 regions of interest we measured, the minimum FA value was 0.22. The FA values of the CST were smaller and more variable in the centrum semiovale than in the other regions. The mean minus twice the standard deviation of the FA values of the CST in the centrum semiovale was calculated at 0.22 on the normal unaffected side and 0.16 on the affected side. Conclusion: An FA value of about 0.20 was found to be the optimal trackability threshold. © 2004 by Japanese Society for Magnetic Resonance in Medicine.
  • Naoto Hayashi, Yasushi Watanabe, Tomohiko Masumoto, Harushi Mori, Shigeki Aoki, Kuni Ohtomo, Osamu Okitsu, Tetsuhiko Takahashi
    Magnetic Resonance in Medical Sciences 3 1 27 - 38 2004年 [査読無し][通常論文]
    The evident advantage of high-field MR (magnetic resonance) scanners is their higher signal-to-noise ratio, which results in improved imaging. While no reliable efficacy studies exist that compare the diagnostic capabilities of low- versus high-field scanners, the adoption and acceptance of low-field MRI (magnetic resonance imaging) is subject to biases. On the other hand, the cost savings associated with low-field MRI hardware are obvious. The running costs of a non-superconductive low-field scanner show even greater differences in favor of low-field scanners. Patient anxiety and safety issues also reflect the advantages of low-field scanners. Recent technological developments in the realm of low-field MR scanners will lead to higher image quality, shorter scan times, and refined imaging protocols. Interventional and intraoperative use also supports the installation of low-field MR scanners. Utilization of low-field systems has the potential to enhance overall cost reductions with little or no loss of diagnostic performance. © 2004 by Japanese Society for Magnetic Resonance in Medicine.
  • Harushi Mori, Shigeki Aoki, Kuni Ohtomo
    Magnetic Resonance in Medical Sciences 3 4 215  2004年 [査読無し][通常論文]
  • A Kunimatsu, S Aoki, Y Masutani, O Abe, H Mori, K Ohtomo
    NEURORADIOLOGY 45 8 532 - 535 2003年08月 [査読無し][通常論文]
    Diffusion tensor MR imaging (DTI) provides information on diffusion anisotropy, which can be expressed with three-dimensional (3D) white matter tractography. We used 3D white matter tractography to show the corticospinal tract in eight patients with acute or early subacute ischaemic stroke involving the posterior limb of the internal capsule or corona radiata and to assess involvement of the tract. Infarcts and the tract were shown simultaneously, providing information on their spatial relationships. In five of the eight patients, 3D fibre tract maps showed the corticospinal tract in close proximity to the infarct but not to pass through it. All these patients recovered well, with maximum improvement from the lowest score on manual muscle testing (MMT) up to the full score through rehabilitation. In the other three patients the corticospinal tract was shown running through the infarct; reduction in MMT did not necessarily improve favourably or last longer, other than in one patient. As 3D white matter tractography can show spatial relationships between the corticospinal tract and an infarct, it might be helpful in prognosis of gross motor function.
  • A. Kunimatsu, O. Abe, S. Aoki, N. Hayashi, T. Okubo, T. Masumoto, H. Mori, T. Yoshikawa, H. Yamada, K. Ohtomo
    Neuroradiology 45 8 524 - 527 2003年08月 [査読無し][通常論文]
    Little is known about the diffusion properties of brain lesions in neuro-Behçet's disease (NBD). We looked at 19 NBD lesions (13 active, six chronic) in six patients, using diffusion-weighted MRI (DWI). We calculated the apparent diffusion coefficients (ADC) of the lesions and compared them with normal contralateral brain, expressing this ratio as relative ADC (rADC). The rADC was 1.29 ± 0.33 in active and 1.44 ± 0.47 in chronic lesions, i.e., significantly higher than in the control regions. Increased diffusivity in both active and chronic phases in NBD is different from the pattern in fischaemic infarcts, so that ADC analysis might be helpful for differentiating between these conditions.
  • S. Aoki, H. Mori, T. Masumoto
    Japanese Journal of Clinical Radiology 48 471 - 480 2003年05月 [査読無し][通常論文]
    Many central nervous system disorders have been genetically analyzed, and now, many degenerative, metabolic as well as vascular diseases have become diagnosed by genetic abnormalities. Relationship between genetic diagnosis and imaging studies will be discussed.
  • O Abe, M Nakane, S Aoki, N Hayashi, T Masumoto, A Kunimatsu, H Mori, A Tamura, K Ohtomo
    NMR IN BIOMEDICINE 16 3 152 - 159 2003年05月 [査読無し][通常論文]
    The goal of this study was to investigate apparent diffusion coefficient (ADC) and T-2 relaxation time (T-2) in the substantia nigra and thalamus after middle cerebral artery occlusion in rats. In the substantia nigra ipsilateral to infarct, ADC was significantly lower and T-2 was significantly higher on the third and fourth days, but they did not change significantly on the first, second, eighth and 15th days. In the ipsilateral thalamus, ADC and T-2 did not change significantly between the first and fourth days, but were significantly lower on the eighth and 15th days. This combination of MR findings suggested that secondary degeneration in the thalamus was different from that in the substantia nigra. Copyright (C) 2003 John Wiley Sons, Ltd.
  • O Abe, S Aoki, Shirouzu, I, A Kunimatsu, N Hayashi, T Masumoto, H Mori, H Yamada, M Watanabe, Y Masutani, K Ohtomo
    EUROPEAN JOURNAL OF RADIOLOGY 46 1 67 - 78 2003年04月 [査読無し][通常論文]
    Cerebral ischemic stroke is one of the most fatal diseases despite current advances in medical science. Recent demonstration of efficacy using intravenous and intra-arterial thrombolysis demands therapeutic intervention tailored to the physiologic state of the individual tissue and stratification of patients according to the potential risks for therapies. In such an era, the role of the neuroimaging becomes increasingly important to evaluate the extent and location of tissues at risk of infarction (ischemic penumbra), to distinguish it from unsalvageable infarcted tissues or doomed hemorrhagic parenchyma. In this review, we present briefly the current role and limitation of computed tomography and conventional magnetic resonance imaging (MRI). We also present the possible applications of advanced MR techniques, such as diffusion and perfusion imaging, concentrating on the delineation or detection of ischemic penumbra. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
  • H Mori, S Aoki, T Okubo, N Hayashi, T Masumoto, T Yoshikawa, M Tago, M Shin, H Kurita, O Abe, K Ohtomo
    NEURORADIOLOGY 45 1 27 - 33 2003年01月 [査読無し][通常論文]
    Assessment of intracranial arteriovenous malformations (AVMs) by conventional catheter angiography carries risks; moreover, this invasive procedure is often repeated for follow-up. We investigated the clinical applicability of two-dimensional thick-slice, contrast-enhanced magnetic resonance digital subtraction angiography (2D MRDSA) with high temporal resolution in the assessment of AVMs. We performed 78 2D MRDSA studies of treated or untreated small to medium-size AVMs on a 1.5 tesla imager. Two observers independently evaluated demonstration of nidus flow void on T2-weighted images and each component of the AVM on 2D MRDSA employing a three-point grading scale. In 55 patients with AVMs, the mean ratings of nidus flow voids, feeding vessels, nidi, draining vessels and early venous filling on MRI were 2.8, 2.4, 2.6, 2.8 and 2.8, respectively. sensitivity, specificity, positive and negative predictive values for an AVM using 2D MRDSA were 87, 100, 100 and 78%, respectively and for nidus flow voids on T2-weighted images 80, 91, 96 and 66%, respectively. 2D MRDSA can thus demonstrate haemodynamic features of AVMs. It can be employed as a less invasive, dynamic angiographic tool for follow-up of AVMs previously delineated by catheter angiography.
  • Harushi Mori, Yoshitaka Masutani, Shigeki Aoki, Osamu Abe, Naoto Hayashi, Tomohiko Masumoto, Haruyasu Yamada, Takeharu Yoshikawa, Akira Kunimatsu, Kuni Ohtomo, Hiroyuki Kabasawa
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 63 1 51 - 3 2003年01月 [査読無し][通常論文]
    Diffusion tensor imaging (DTI), a magnetic resonance (MR) technique to analyze diffusion anisotropy of the brain, is able to demonstrate subtle white matter anatomy. Tractography is expected to be a unique, non-invasive tool to provide more pertinent insights into brain structure and orientation not accessible by conventional MRI. In this report, preliminary experiences of visualization of the corticospinal tract using tractography are described. DTI of the brain was performed in 5 normal volunteers using single-shot echo-planar imaging, then tractography was generated by our original software. We determined that the two-region-of-interest (ROI) method is superior to the one-ROI method.
  • Naoto Hayashi, Yoshitaka Masutani, Tomohiko Masumoto, Harushi Mori, Akira Kunimatsu, Osamu Abe, Shigeki Aoki, Kuni Ohtomo, Naoki Takano, Kazuhiko Matsumoto
    Magnetic Resonance in Medical Sciences 2 1 29 - 36 2003年 [査読無し][通常論文]
    Purpose: To assess the feasibility of a curvature-based enhanced display system for detecting cerebral aneurysms in MR angiography. Methods: MR angiography studies of 18 patients (eight male and 10 female, average age 65.7, age range 50 to 75 years old) with 23 known aneurysms were evaluated with a curvature-based display system. The two curvature features-the volumetric shape index and curvedness values-were calculated at each voxel. These were displayed independently on a workstation, overlaid on volume-rendered images. Two neuroradiologists evaluated the images for visibility and diagnosis of the cerebral aneurysms. The diagnostic results were compared with the original reports. Results: The calculation time for each curvature index was 30 to 40 s for 120 to 140 slices of original MR angiography data. Shape index images emphasized smooth and round aneurysms more than aneurysms with irregular surfaces. Curvedness images revealed aneurysms well when the aneurysms had diameters that differed from those of the surrounding vessels. The computer-assisted-detection method detected 24 aneurysms, three of which were not pointed out in the initial report. Conclusion: Our results show that the curvature-based display system we have developed is feasible and that it may help to detect small aneurysms that are prone to be overlooked in routine readings.
  • Tomohiko Masumoto, Naoto Hayashi, Harushi Mori, Shigeki Aoki, Osamu Abe, Kuni Ohtomo, Takayuki Abe, Tetsuhiko Takahashi
    Magnetic Resonance in Medical Sciences 2 2 97 - 103 2003年 [査読無し][通常論文]
    Purpose: The purpose of this study was to develop a new technique for a high temporal resolution two-dimensional MR digital subtraction angiography (2D MRDSA) sequence under intraarterial injection of contrast material to permit the visualization of vascular anatomy and hemodynamics. Methods: 2D MRDSA was imaged on a 0.3T open MR scanner with a T1-weighted fast gradient echo sequence. The phantom study examined vials containing gadolinium (Gd) solutions ranging in concentration from 0.5 mmol/L to 100 mmol/L. Repetition time and echo time were fixed at minimal values in order to achieve high temporal resolution, and only the flip angle was changed in 10-degree increments between 10 and 90 degrees. The in vivo study examined a brachial artery of a human volunteer. MRDSA images were acquired continuously during intraarterial injections of Gd solutions ranging in concentration from 0.5 mmol/L to 100 mmol/L. The subtracted images were displayed on the monitor in real time at a frame rate of one frame per second and evaluated to determine the optimal concentration of contrast material. Results: In the phantom study, a 10-mmol/L Gd concentration with a flip angle of 50°-90° and a 25-mmol/L Gd concentration with a flip angle of 60°-90° showed high signal-to-noise ratios. In the human brachial artery experiment, the forearm arteries were well visualized when solutions of 5-50 mmol/L Gd concentration were used. The 10- and 25-mmol/L Gd concentrations were considered optimal. The palmar digital arteries were also visualized. Higher Gd concentrations showed a paradoxical signal increase when diluted by blood. Conclusion: We successfully developed an intraarterial contrast-enhanced 2D MRDSA sequence. With appropriate settings of imaging parameters and Gd concentrations, we obtained acceptable vessel visualization in the human study. The low Gd concentration for optimal visualization permits repeated intraarterial injections. This technique can be a useful tool for investigating the vascular anatomy and hemodynamics required for MR-guided vascular interventions.
  • Harushi Mori, S. Aoki, M. Shin, M. Tago, T. Masumoto, T. Yoshikawa, N. Hayashi, O. Abe, K. Ohtomo
    Rivista di Neuroradiologia 15 6 737 - 743 2002年12月 [査読無し][通常論文]
    We present the contrast-enhanced dynamic MR imaging appearance of cerebral arteriovenous malformations (AVM) following gamma knife radiosurgery and discuss the implications of this finding with respect to treatment. Dynamic MR images obtained in our three AVM patients following radiosurgery revealed slowly enhancing lesions. This pattern is not observed in all cases involving AVMs following gamma knife radiosurgery. When it is present, a haemangioma-like lesion should be considered.
  • Harushi Mori, N. Hayashi, S. Aoki, O. Abe, T. Masumoto, T. Yoshikawa, K. Ohtomo, T. Shinoe, T. Nakamoto
    Rivista di Neuroradiologia 15 6 763 - 768 2002年12月 [査読無し][通常論文]
    We describe the clinical features and MRI findings of a patient with hypereosinophilia-induced encephalopathy associated with human T-cell lymphotropic virus type 1. Initial diffusion-weighted images revealed hyperintense spots in the border zone, and the apparent diffusion coefficient of the lesions increased over a three-week follow-up period. MRI findings, particularly those of the diffusion-weighted images, are of diagnostic value and are helpful in terms of understanding the pathophysiology of this disease.
  • Harushi Mori, O. Abe, K. Maruyama, M. Shin, M. Tago, T. Masumoto, T. Yoshikawa, H. Yamada, N. Hayashi, S. Aoki, K. Ohtomo
    Rivista di Neuroradiologia 15 6 769 - 772 2002年12月 [査読無し][通常論文]
    We describe a patient with a rare association of a parietal arteriovenous malformation (AVM) and an ipsilateral persistent primitive hypoglossal artery (PPHA). A 27-year-old woman was treated by surgical removal, followed by gamma-knife radiosurgery. Only seven cases of intracranial AVM associated with PPHA have been reported in the literature. Although AVM associated with persistent carotid-basilar anastomosis has no distinguishing features compared with ordinary AVM, early recognition of the association is of significance to minimize neurological deficits during diagnostic angiography, interventional radiology (embolization) and surgery. The present report adds to the growing literature regarding AVMs associated with carotid-basilar anastomoses.
  • Harushi Mori, Makoto Watanabe, Masaaki Akahane, Choku Yajima, Kuni Ohtomo
    Nippon Acta Radiologica 62 14 834 - 835 2002年12月 [査読無し][通常論文]
    A case of complex regional pain syndrome (CRPS ) secondary to peripheral nerve injury occurring during venipuncture for post-contrast CT examination is presented. The puncture site was in the left antecubital fossa. Anatomically, cutaneous nerves lie close to cutaneous veins, making them vulnerable to injury during the procedure. This syndrome is characterized by continuing pain, allodynia, or hyperalgesia that is disproportionate to any inciting event in severity, and may lead to loss of the involved limb. The syndrome is poorly understood by radiologists and is often misdiagnosed. Early recognition and appropriate therapy are most important in treating this disorder.
  • H Mori, O Abe, S Aoki, T Masumoto, T Yoshikawa, A Kunimatsu, N Hayashi, K Ohtomo
    ACTA RADIOLOGICA 43 6 563 - 566 2002年11月 [査読無し][通常論文]
    Diffusion-weighted MR imaging has been applicable to the differential diagnosis of abscesses and necrotic or cystic brain tumors. However, restricted water diffusion is not necessarily specific for brain abscess. We describe ring-enhancing metastases of lung carcinoma characterized by high signal intensity on diffusion-weighted MR images. The signal pattern probably reflected intralesional hemorrhage. The present report adds to the growing literature regarding the differential diagnosis of ring-enhancing brain lesions.
  • Harushi Mori, Shigeki Aoki, Tomohiko Masumoto, Takeharu Yoshikawa, Masao Tago, Masahiro Shin, Kuni Ohtomo, Hiroyuki Kabasawa
    Radiation Medicine - Medical Imaging and Radiation Oncology 20 5 223 - 229 2002年09月 [査読無し][通常論文]
    Objective: Array spatial sensitivity encoding techniques (ASSET) were employed to improve the temporal resolution of two-dimensional (2D) thick-slice contrast-enhanced magnetic resonance digital subtraction angiography (MRDSA). Methods: 2D MRDSA using ASSET was performed in 28 patients via fast spoiled gradientecho sequence (TR/TE 5.4/1.5 ms FA 60 FOV 24x24 cm matrix size 256x256 slice thickness 50-70 mm), followed by a bolus injection of gadolinium chelate and subsequent saline flush, for 40 seconds on a sagittal plane. Images were evaluated for visualization of normal intracranial vessels and brain lesions utilizing a three-point scale additionally, in 10 of the 28 patients, results were compared with those of conventional 2D MRDSA. Results: 2D MRDSA using ASSET, which improved temporal resolution from 1.45 to 0.77 seconds, displayed image quality comparable to that of conventional 2D MRDSA. Moreover, this technique afforded superior detectability with respect to early venous filling in patients with arteriovenous malformations (AVMs). Conclusion: ASSET improves the temporal resolution of 2D MRDSA without compromising spatial resolution.
  • T Yoshikawa, O Abe, K Tsuchiya, T Okubo, K Tobe, T Masumoto, N Hayashi, H Mori, H Yamada, S Aoki, K Ohtomo
    NEURORADIOLOGY 44 6 481 - 488 2002年06月 [査読無し][通常論文]
    Magnetic resonance imaging (MRI) is useful to diagnose dural sinus thrombosis. However, the representative appearance of dural sinus thrombosis on diffusion-weighted MRI has not been established. This study was aimed at determining whether cytotoxic or vasogenic edema is more predominant in the affected cerebral parenchyma and assessing the time courses and prognosis of dural sinus thrombosis lesion. The studies on sixteen patients with dural sinus thrombosis who underwent diffusion-weighted MRI were retrospectively reviewed. The diagnosis was confirmed by digital subtraction angiography in 11 patients and magnetic resonance angiography in five patients. Diffusion-weighted images with echo-planar imaging were obtained using two or three b values, with the highest b value of up to 1,000 s/mm(2). A region of interest was placed on an area of abnormal signal intensity to calculate apparent diffusion coefficients (ADCs). Nine of the 16 patients had lesions with an increased ADC, whereas, three of these nine patients also had lesions with a decreased ADC. Among 11 patients who underwent initial MRI within 7 days of their last episode, eight had lesions with an increased ADC, of whom three had lesions mixed with both decreased and increased ADC areas. Follow-up studies of these three patients revealed the development of hemorrhagic infarction in two and subcortical hemorrhage in one. Vasogenic edema develops more predominantly and earlier in dural sinus thrombosis, though cytotoxic edema was also associated with the pathological changes in the early phase. Decrease of ADC value is presumed to reflect severe pathological conditions and indicate possible future development of infarction or hemorrhage.
  • Harushi Mori, Shigeki Aoki, Osamu Abe, Yoshitaka Masutani, Tomohiko Masumoto, Naoto Hayashi, Takeharu Yoshikawa, Yasushi Watanabe, Yoshirou Satake, Kuni Ohtomo, Hiroyuki Kabasawa
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 62 6 287 - 9 2002年05月 [査読無し][通常論文]
    Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction (PROPELLER) MR imaging (MRI) has a unique ability to correct motion artifacts and is expected to be useful in diffusion-weighted MRI. This article describes preliminary experiences with PROPELLER MRI. PROPELLER uses a radial scan variation of the fast spin-echo sequence and it shows much less spatial deterioration than the echo-planar imaging sequence. To determine the optimal parameters of this technique, we calculated the signal intensities of phantoms and brains in various settings. PROPELLER MR examinations were also performed in 66 patients for clinical use. PROPELLER MRI appears to be a promising and useful technique.
  • Harushi Mori, N. Hayashi, S. Aoki, S. Fuwa, T. Yoshikawa, A. Kunimatsu, H. Yamada, K. Saito, T. Masumoto, O. Abe, K. Ohtomo
    Japanese Journal of Clinical Radiology 47 3 441 - 447 2002年 [査読無し][通常論文]
    We surveyed to assess for the incidence of clinically silent brain infarction after cerebral catheter angiography. Diffusion-weighted images were performed shortly after 33 cerebral catheter angiographies. We found totally 11 abnormally high intensity spots in 5 of 33 patients on diffusion-weighted images and, therefore, the incidence was calculated as 15.2%. This incidence is higher than has been estimated based on the incidence of neurological deficits (about 0.5%) after cerebral angiography. Diffusion-weighted MR imaging is suitable to monitor the safety of angiographic procedures and material.
  • Harushi Mori, Naoto Hayashi, Shigeki Aoki, Tomohiko Masumoto, Takeharu Yoshikawa, Osamu Abe, Kuni Ohtomo, Tadashi Yuge, Kimitaka Kaga
    Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica 62 1 32 - 34 2002年01月 [査読無し][通常論文]
    We performed selective intraarterial infusion chemotherapy using a combined MRI-angiography system for head and neck cancers. In three patients, three or five infusions of CDDP (100 mg/body) were administered to the feeding arteries selectively. For the evaluation of drug distribution, MRI during arteriography through the infusion pump was performed before CDDP administration. When a distribution mismatch was found, arterial selection was attempted again under a mechanically unstable C-arm system, and further evaluation under an MR system was carried out. Thus, more ideal treatment could be provided. We consider MRI during arteriography to be useful in assessing for distribution during intraarterial chemotherapy.
  • Harushi Mori, N. Hayashi, S. Aoki, O. Abe, Y. Masutani, K. Ohtomo, M. Hirakawa, Y. Ugawa
    Japanese Journal of Clinical Radiology 47 11 1629 - 1632 2002年 [査読無し][通常論文]
    Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction (PROPELLER) is one of newer magnetic resonance imaging (MRI) methods that are developed to correct motion artifacts. PROPELLER uses a radial scan variation of the fast spin-echo sequence and allows one to correct spatial inconsistencies using self navigation and an averaging effect for low spatial frequencies. We report a case of restless patient with a variety of progressive neurological symptoms whose PROPELLER T2-weighted images were high quality enough for the evaluation of a pulvinar sign.
  • Osamu Abe, Shigeki Aoki, Naoto Hayashi, Haruyasu Yamada, Akira Kunimatsu, Harushi Mori, Takeharu Yoshikawa, Toshiyuki Okubo, Kuni Ohtomo
    Neurobiology of Aging 23 3 433 - 441 2002年 [査読無し][通常論文]
    The purpose of this study is to elucidate changes in mean diffusivity (ADC) and fractional anisotropy (FA) using MR diffusion tensor imaging (DTI) in the central nervous system during normal aging. We studied 50 normal volunteers (30 men, 20 women; mean age 44.8 ± 14.0; age range, 21-69 years) without disorders affecting the central nervous system. The frontal, parietal white matter, lentiform nucleus, posterior limb of internal capsule, thalamus, genu and splenium of the corpus callosum were selected for investigation. There was no significant difference in ADC or FA between male and female or between the right and left hemisphere. A significant ADC increase with advancing age was observed in frontal white matter (P = 0.010) and lentiform nucleus (P = 0.022). A significant FA decline was found only in the genu of the corpus callosum (P < 0.001) with advancing age. Quantitative diffusion tensor analysis correlate with normal aging and may help in assessing normal age-related changes and serve as a standard for comparison with neurodegenerative disorders. © 2002 Elsevier Science Inc. All rights reserved.
  • Harushi Mori, Hiroshi Yoshioka, Kensaku Mori, Tayeb Ahmadi, Toshiyuki Okumura, Yukihisa Saida, Yuji Itai
    Radiation Medicine - Medical Imaging and Radiation Oncology 20 2 69 - 76 2002年 [査読無し][通常論文]
    Purpose: Although it is documented that radiation can cause density or intensity changes on computed tomography or MR imaging in the irradiated hepatic parenchyma, few researchers have reported or understood the MR presentation of changes in hepatic parenchyma following radiotherapy in the patient with Budd-Chiari syndrome. The purpose of this study was to investigate the MR appearance of hepatic radiation injury in Budd-Chiari syndrome and to consider the underlying pathophysiology. Materials and Methods: The MR examinations of two patients with Budd-Chiari syndrome were compared with those of 11 patients without Budd-Chiari syndrome. The two groups, both of which suffered from hepatocellular carcinoma, underwent 50-72 Gy of proton-beam irradiation during a period of 14-43 days. Examinations including T1- and T2-weighted imaging, superparamagnetic iron oxide-enhanced imaging, and dynamic study were performed 3-10 weeks after the end of irradiation. Results: Radiation-induced hepatic injury was observed as a low-intensity area on T2-weighted images and on delayed phase images of dynamic study in the Budd-Chiari patients, and as iso- or high-intensity areas on both images in the patients without Budd-Chiari syndrome. US-guided needle biopsy from the irradiated area in one patient with Budd-Chiari syndrome revealed mostly necrotic tissue and fibrous tissue. Conclusion: These MR features of hepatic radiation injury in Budd-Chiari syndrome were considered to be due to severe hepatic fibrosis.
  • Harushi Mori, Osamu Abe, Toshiyuki Okubo, Naoto Hayashi, Takeharu Yoshikawa, Akira Kunimatsu, Haruyasu Yamada, Shigeki Aoki, Kuni Ohtomo
    Journal of Computer Assisted Tomography 25 4 537 - 539 2001年 [査読無し][通常論文]
    Though diffusion-weighted MRI has been applied to various intracranial lesions, few reports had been presented about cerebral hamartomatous lesions in patients with neurofibromatosis type 1 (NF1). In this study, we report the interval changes of apparent diffusion coefficient (ADC) in a presumed hamartomatous lesion. In our case, the ADC increased slightly over a 3 year period. This diffusion property may provide specific insight into the etiology of cerebral hamartomatous lesions observed in NF1.
  • K. Mori, H. Yoshioka, Y. Itai, Y. Okamoto, H. Mori, N. Takahashi, Y. Saida
    American Journal of Roentgenology 175 6 1659 - 1664 2000年 [査読無し][通常論文]
    OBJECTIVE. The study objective was to distinguish between the features of tumorous and nontumorous arterioportal shunts on superparamagnetic iron oxide - enhanced MR imaging in patients with cirrhosis. SUBJECTS AND METHODS. Ten arterioportal shunts in eight patients, including four tumorous and six nontumorous arterioportal shunts, were evaluated on T2-weighted turbo spin-echo and T2(*)-weighted gradient-echo sequences before and after administration of superparamagnetic iron oxide. Qualitatively, the relative signal intensity of the arterioportal shunt compared with that of the surrounding liver parenchyma was categorized into three grades: high, slightly high, and not detected. Quantitatively, signal-to-noise ratio, contrast-tonoise ratio, lesion-to-liver contrast, and percentage enhancement were calculated and compared between tumorous and nontumorous arterioportal shunts by a nonparametric statistical test (Mann-Whitney test). RESULTS. Qualitatively, all four tumorous arterioportal shunts appeared as areas of slightly high or high intensity without and with superparamagnetic iron oxide on T2-weighted turbo spin-echo images and changed from isointensity to high intensity after the administration of superparamagnetic iron oxide on T2(*)-weighted gradient-echo images. All nontumorous arterioportal shunts except one could not be recognized without or with superparamagnetic iron oxide on either sequence. Quantitatively, with superparamagnetic iron oxide the contrast-to-noise ratio and the lesion-to-liver contrast of the tumorous arterioportal shunts were significantly higher than those of the nontumorous arterioportal shunts. CONCLUSION. Tumorous arterioportal shunts are seen as areas of reduced signal loss, whereas most nontumorous arterioportal shunts are seen as areas of normal signal loss, like the normal liver parenchyma. The difference is more marked on T2(*)-weighted gradient-echo images than on T2-weighted turbo spin-echo images.
  • H. Mori, Y. Saida, Y. Watanabe, T. Irie, Y. Itai
    Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica 60 702 - 704 2000年01月 [査読無し][通常論文]
    We devised a simple "pumping" method to make gelatin sponge particles for transcatheter arterial embolization. As the frequency of pumping increased, the number of particles 0.2-1.6 mm in diameter increased, whereas no particles of more than 3.2 mm in diameter were present after 20 pumpings. After passing through the microcatheter, particles of less than 0.2 mm in diameter were relatively increased by about 10 points in both the pumping and cutting methods. It was histologically demonstrated that the size of embolized arteries corresponded well to the size of particles. These results suggest that our "pumping" method offers sufficient quality for transcatheter arterial embolization.
  • Harushi Mori, Hiroshi Yoshioka, Tayeb Ahmadi, Yukihisa Saida, Kiyoshi Ohara, Yuji Itai
    Journal of Computer Assisted Tomography 24 4 648 - 651 2000年 [査読無し][通常論文]
    Early radiation-induced liver injury during radiotherapy detected by a particulate reticuloendothelial MR contrast agent (superparamagnetic iron oxide SPIO) is described in a patient with cholangiocarcinoma. The irradiated hepatic parenchyma appeared as a heterogeneous, less decreased signal intensity area than the nonirradiated area on MR images after SPIO administration. Resultant differences in signal intensity were better visualized on SPIO-enhanced T1-weighted images than SPIO-enhanced T2-weighted images, although SPIO-enhanced T2*-weighted fast field echo imaging was the most sensitive.
  • Hiroshi Yoshiokaa, Yuji Itai, Yukihisa Saida, Kensaku Mori, Harushi Mori, Toshiyuki Okumura
    Magnetic Resonance Imaging 18 9 1079 - 1088 2000年 [査読無し][通常論文]
    Superparamagnetic iron oxide (SPIO)-enhanced MRI was performed in twenty-one patients undergoing proton-beam radiotherapy for hepatocellular carcinomas. Patients were divided into two groups: early and late phase hepatic injuries. Each group was investigated 3 to 9 weeks and 4 to 65 months after the start of irradiation, respectively. T1-weighted, T2-weighted, and T2*-weighted images were obtained before and after SPIO administration. In all postcontrast sequences in the early phase, irradiated livers demonstrated relatively higher intensity than nonirradiated livers and the radiation-to-liver contrast-to-noise ratio (C/N) was improved. Postcontrast T2*-weighted images showed the highest C/N. In the late phase, the irradiated areas showed high intensity on T2-weighted images and low intensity on T1-weighted images without SPIO, while high intensity on T1-weighted images with SPIO. The C/N increased with SPIO in all sequences and postcontrast T2-weighted images showed the highest C/N in the late phase. SPIO-enhanced MRI is useful to evaluate this entity both in the early and late phase of clinical studies. (C) 2000 Elsevier Science Inc.


  • 画像で診る遺伝性白質 疾患診断の手引き
    髙梨潤一,小坂仁,森墾,吉田誠克(責任編集):厚生労働科学研究費補助金難治性疾患政策研究事業遺伝性白質疾患・知的障害をきたす疾患の診断・治療, 研究システム構築班(編集) (担当:編者(編著者))
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    金原出版 2016年
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    医薬ジャーナル社 2016年
  • 厚生労働科学研究費補助金(新興・再興感染症及び予防接種政策推進研究事業)日本脳炎ならびに予防接種後を含む急性脳炎・脳症の実態・病因解明に関する研究 平成27年度 総括・分担研究報告書(多屋馨子:研究代表者).
    多屋馨子, 吉良龍太郎, チョンピンフィー, 奥村彰久, 森墾, 鳥巣浩幸, 安元佐和, 清水博之 (担当:分担執筆範囲:?.分担研究報告.2.2015年秋に多発した急性弛緩性麻痺症例に関する臨床・疫学研究.)
    国立感染症研究所 感染症疫学センター 2016年
  • 免疫症候群(第2版)?―その他の免疫疾患を含めて―,別冊 日本臨牀 新領域別疾患シリーズ No.35
    森 墾, 國松 聡, 大友 邦, 坂信之 (担当:分担執筆範囲:? アレルギー疾患 24. 薬物アレルギー (3)造影剤によるアナフィラキシー)
    日本臨牀社 2016年
  • 救急画像診断のすべて,臨床放射線60(臨時増刊号)
    森墾,國松聡, 大友邦(編集, 臨床放射線編集委員 (担当:分担執筆範囲:各論.内因性疾患1. 頭部【代謝変性疾患】 一酸化炭素中毒)
    金原出版 2015年
  • こう読む 認知症 原因診断のための脳画像―内科系と脳外科の診断流儀―
    森墾(編集, 松田博史, 田隆 (担当:分担執筆範囲:認知症を伴う筋萎縮性側索硬化症ALS with Dementia (ALS-D))
    ぱーそん書房 2015年
  • まるわかり頭頸部領域の画像診断
    森墾(編集, 豊田圭子 (担当:分担執筆範囲:3章 頭蓋底・脳神経:総論,鑑別診断と画像診断の進め方,前頭蓋底部・嗅窩部髄膜腫,側頭髄膜瘤・脳瘤,線維性異形成,癌の頭蓋底への浸潤,神経性食欲不振症,血液疾患における,頭蓋骨の変化,16章 全身疾患:術後リンパ増殖性疾患,メトトレキサート関連,リンパ増殖性疾患)
    学研メディカル秀潤社 2015年
  • 頭頸部画像診断に必要不可欠な臨床・画像解剖
    森墾(編集, 尾尻博也 (担当:分担執筆範囲:4.脳神経)
    学研メディカル秀潤社 2015年
  • Routine Clinical MRI 2015 Book,映像情報Medical46
    森墾 (担当:分担執筆範囲:波打ち際で, 総ての波をやり過ごし, あるいは溺れ)
    映像情報メディカル 2015年
  • エキスパートのための脊椎脊髄疾患のMRI.第3版
    柳下章, 相田典子, 江原茂, 勝俣康史, 森墾 (担当:共著)
    三輪書店 2015年
  • CT・MRI”戦略的”活用ガイド medicina51(2014増刊号)
    森墾(編集, 大友邦, 前田恵理子 (担当:分担執筆範囲:CT・MRI検査の注意事項.リスクマネジメント:事故やエラーを防ぐための心得)
    医学書院 2014年
  • 悪性リンパ腫の診断と治療【画像診断―鑑別診断に重点をおいて―】臨床放射線(臨時増刊号)59
    森墾,國松聡, 大友邦(編集, 臨床放射線編集委員 (担当:分担執筆範囲:中枢神経系(HIV関連を含む))
    金原出版 2014年
  • 【放射線科医が診断すべき日常診療で迷う症例】画像診断34(臨時増刊号)
    國松聡, 住田薫, 桂正樹, 雨宮史織, 森墾, 高尾英正, 佐々木弘喜, 大友邦 (担当:分担執筆範囲:第5章 中枢神経−迷う原因別3パターンの症例−)
    秀潤社 2014年
  • 圧倒的画像数で診る!頭部疾患画像アトラス
    土屋一洋, 山田惠,森墾 (担当:共著範囲:第7章2.急性硬膜下血腫.)
    羊土社 2014年
  • 画像診断別冊KEY BOOKシリーズ:よくわかる脳MRI(第3版)
    森墾(編集, 青木茂樹, 相田典子, 井田正博, 場洋 (担当:分担執筆範囲:gliomatosis cerebri,多形黄色星細胞腫,可逆性脳血管攣縮症候群,認知症を伴う筋萎縮性側索硬化症,多系統萎縮症,皮質性小脳萎縮症,小脳萎縮・低形成を来す代謝・変性疾患について,)
    秀潤社 2013年
  • 第3版 MRI応用自在
    森墾(監修, 高原太郎 (担当:分担執筆範囲:?2 高速SE法T2WI関連: PROPELLER/BLADE/MultiVANE/JET/RADER)
    メジカルビュー 2013年
  • これでわかる拡散MRI 第3版
    森墾(編集, 青木茂樹, 阿部修, 増谷佳孝, 高原太郎 (担当:分担執筆範囲:拡散テンソルによる各種白質路と白質アトラス,メトトレキセート脳症(MTX脳症)HHE症候群,)
    秀潤社 2013年
  • 単純X線写真の読み方・使い方
    森墾(編集, 黒崎喜久 (担当:分担執筆範囲:?.骨軟部組織.2章.脊椎外傷―好発所見を覚えましょう―)
    医学書院 2013年
  • 頭部画像解剖 徹頭徹尾.疾患を見極め的確に診断する
    森墾(編集, 蓮尾金博 (担当:分担執筆範囲:?.脳実質の構造 1.皮質;脳回・脳溝)
    メジカルビュー 2013年
  • 子どものけいれん・てんかん.見つけ方・見分け方から治療戦略へ
    森墾,桂正樹, 國松聡(編集, 奥村彰久, 浜野晋一郎 (担当:分担執筆範囲:10.頭部MRI)
    中山書店 2013年
  • 脳・脊髄の連想画像診断.画像に見えないものを診る
    森墾 (担当:単著)
    メジカルビュー 2013年
  • 【癌取扱い規約からみた悪性腫瘍の病期診断と画像診断2012年版】 臨床放射線(臨時増刊号)57
    豊田圭子, 森墾, 大原有紗, 大場洋 (担当:分担執筆範囲:眼部腫瘍:眼内腫瘍)
    金原出版 2012年
  • 【神経難病疾患のリハビリテーション―ケーススタディーを通して学ぶ】 JOURNAL OF CLINICAL REHABILITATION別冊
    森墾, 柳下章, 編集, 江藤文夫, 中馬孝容, 葛原茂樹 (担当:分担執筆範囲:第1章 総論:1. 神経難病疾患の診断のトピックス:(2)画像診断)
    医歯薬出版 2012年
  • 厚生労働科学研究費補助金(難治性疾患克服研究事業) 胎児診断における難治性脳形成障害症の診断基準の作成(H22-難治-一般-131) 平成23年度総括・分担研究報告書
    宇都宮英綱, 相田典子, 大場洋, 森墾(研究協力 (担当:分担執筆範囲:難治性脳形成障害症データバンクにおける遠隔画像診断に関する研究―脳回・脳溝形成不全のMRI診断について―,難治性脳形成障害症データバンクにおける遠隔画像診断に関する研究―画像解析結果報告―)
    編集室なるにあ 2012年
  • 決定版 頭部画像診断パーフェクト―310疾患で鉄壁の「診断力」を身につける!
    森墾(編集, 土屋一洋, 前田正幸, 川章 (担当:分担執筆範囲:Marchiafava-Bignami病,一過性脳梁膨大部病変,低血糖脳症,PRES,可逆性脳血管攣縮症候群, 高好酸球性脳症, 家族性片麻痺性片頭痛, 糖尿病性舞踏病, 肝性脳症, 低酸素虚血性脳症, 一酸化炭素中毒,)
    羊土社 2011年
  • 厚生労働科学研究費補助金(難治性疾患克服研究事業) 胎児診断における難治性脳形成障害症の診断基準の作成(H22-難治-一般-131) 平成22年度総括・分担研究報告書
    宇都宮英綱, 相田典子, 大場洋, 森墾(研究協力 (担当:分担執筆範囲:難治性脳形成障害症データバンクにおける遠隔画像診断に関する研究,)
    編集室なるにあ 2011年
  • 【内分泌腺腫瘍―基礎・臨床研究のアップデート―】日本臨牀増刊号
    森典子, 森墾(編集, 平田結喜緒 (担当:分担執筆範囲:5. 副甲状腺腫瘍検査・診断.3) 画像診断)
    日本臨牀社 2011年
  • ビジュアル脳神経外科Anatomy & Surgical Approach 2:側頭葉・後頭葉
    森墾(担当編集, 斉藤延人 (担当:分担執筆範囲:側頭葉・後頭葉のCT・MRI)
    メジカルビュー 2010年
  • 《小児科臨床ピクシス》ここまでわかった小児の発達
    森墾(総編集, 五十嵐隆, 専門編集, 久保田雅也 (担当:分担執筆範囲:MRIを用いた小児の発達の解析)
    中山書店 2010年
  • 厚生労働科学研究費補助金(難治性疾患克服研究事業) 胎児診断における難治性脳形成障害症の診断基準の作成(H21-難治-一般-028) 平成21年度総括・分担研究報告書
    山崎麻美, 森墾(研究協力 (担当:分担執筆)
    編集室なるにあ 2010年
  • 小児神経の画像診断‐脳脊髄から頭頸部・骨軟部まで‐
    森墾(編集, 大場洋 (担当:分担執筆範囲:7.小児・若年者の脳梗塞,11-2.小脳萎縮・脳幹部萎縮を来す変性・代謝疾患,17-3.脊髄・脊椎変性疾患・炎症性疾患・他)
    秀潤社 2010年
  • エキスパートのための脊椎脊髄疾患のMRI.第2版
    柳下章, 江原茂, 相田典子, 森墾 (担当:共著)
    三輪書店 2010年
  • 新版 所見からせまる脳MRI系統鑑別診断
    森墾(編集, 土屋一洋, 青木茂樹, 大場洋, 下野太郎 (担当:分担執筆範囲:両側小脳の異常)
    秀潤社 2008年
  • カンファランス形式頭部画像診断演習
    森墾(監修, 土屋一洋 (担当:分担執筆範囲:類上皮腫,類皮嚢胞,頭蓋咽頭腫,Rathke嚢胞,神経下垂体部胚腫,松果体部成熟奇形腫)
    秀潤社 2006年
  • これだけ押さえれば大丈夫1 頭部画像診断の勘ドコロ
    森墾, 前田正幸, 高橋雅士 (担当:分担執筆範囲:5. 脱髄・代謝・変性)
    メジカルビュー 2006年
  • できる!画像診断入門シリーズ 頭部画像診断のここが鑑別のポイント
    森墾(監修, 土屋一洋 (担当:分担執筆範囲:大脳基底核変性症,パントテン酸キナーゼ関連深頚変性症,遺伝性脊髄小脳変性症,孤発性脊髄小脳変性症,多系統萎縮症)
    羊土社 2005年
  • 新版 これでわかる拡散MRI, 拡散テンソルによる各種白質路と白質アトラス,脊髄小脳変性症,HHE症候群,神経線維腫症1型,pp.162-165,284-285,354-355,372-373
    森墾(編集, 青木茂樹, 阿部修, 増谷佳孝 (担当:分担執筆範囲:拡散テンソルによる各種白質路と白質アトラス,脊髄小脳変性症,HHE症候群,神経線維腫症1型)
    秀潤社 2005年
  • エキスパートのための脊椎脊髄疾患のMRI
    柳下章, 井上佑一, 相田典子, 森墾 (担当:共著)
    三輪書店 2004年
  • 画像診断別冊KEY BOOKシリーズ:新版よくわかる脳MRI
    森墾(編集, 青木茂樹, 相田典子, 井田正博, 場洋 (担当:分担執筆範囲:多形黄色星細胞腫,gliomatosis cerebri,DIG/DIA,supratentorial PNET,脳梁形成異常,5-FU脳症,低酸素脳症,低髄圧症候群,小脳萎縮を来す変性疾患)
    秀潤社 2004年
  • 改訂版 MRI応用自在
    森墾(監修, 蜂屋順一 (担当:分担執筆範囲:?高速SE法関連:PROPELLER)
    メジカルビュー 2004年
  • 臨床指南 小児神経放射線
    森墾, 小松秀平, 青木茂樹, 林直人, 阿部修, 増谷佳孝, 増本智彦, 山田晴耕, 吉川健啓, 國松聡, 大友 邦 (担当:分担執筆範囲:成長に伴う脳・頭蓋の画像所見の変化)
    メジカルビュー 2004年
  • 消化器CT−読み方・考え方
    森墾, 大友邦 (担当:分担執筆範囲:11 食道・胃)
    日本メディカルセンター 2003年
  • 【これだけは知っておきたい臨床医の画像診断】臨床医29増刊号
    森墾(編集, 土屋一洋 (担当:分担執筆範囲:星細胞腫,髄膜腫,悪性リンパ腫)
    中外医学社 2003年
  • 手術と病理の理解のための頭部画像診断
    森墾(編集, 土屋一洋, 青木茂樹, 平戸純子, 森田明夫 (担当:分担執筆範囲:Pleomorphic xanthoastrocytoma,Central neurocytoma)
    秀潤社 2003年
  • 医学大辞典.
    森墾(編集, 伊藤正男, 井村裕夫, 高久史麿 (担当:分担執筆)
    医学書院 2003年
  • これでわかる拡散MRI
    森墾(編集, 青木茂樹, 部修 (担当:分担執筆範囲:脊髄小脳変性症,神経線維腫症1型)
    秀潤社 2002年
  • ルーチンクリニカルMRI BOOK2003
    森墾, 青木茂樹, 阿部修, 増谷佳孝, 増本智彦, 林直人, 吉川健啓, 國松聡, 山田晴耕, 齊藤公章, 渡辺靖志, 佐竹芳朗, 後藤政実, 井野賢司, 長谷川浩章, 美馬和男, 大友邦, 椛沢宏之 (担当:分担執筆範囲:PROPELLER MRI:その原理と応用.)
    映像情報メディカル 2002年
  • CT・MRI●Key Words Index 1 頭部CT・MRI診断のキーワード99
    森墾(編集, 土屋一洋 (担当:分担執筆範囲:脳腫瘍)
    メジカルビュー 2001年
  • 【小児神経放射線診断】臨床画像17(4月増刊号)
    阿部修, 青木茂樹, 大久保敏之, 林直人, 山田晴耕, 吉川健啓, 國松聡, 森墾, 大友邦 (担当:分担執筆範囲:小児中枢神経疾患の画像診断技術.)
    メジカルビュー 2001年
  • Clinician's Journal
    大友邦,森墾 (担当:分担執筆範囲:Imagin Library)
    Japan MediArt Publishing


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    第77回日本医学放射線学会総会 2019年 公開講演,セミナー,チュートリアル,講習,講義等
  • 教育講演?:脳腫瘍・病理 脳腫瘍と類似疾患 一般総括.  [通常講演]
    第42回日本脳神経CI学会総会 2019年 公開講演,セミナー,チュートリアル,講習,講義等
  • 画像診断クイズ 難関画像に挑戦せよ  [通常講演]
    第41回日本脳神経CI学会総会 2018年 シンポジウム・ワークショップパネル(指名)
  • アーチファクト  [通常講演]
    第40回磁気共鳴学会講座 2018年 公開講演,セミナー,チュートリアル,講習,講義等
  • 拡散強調画像DWI revisited  [通常講演]
    第60回日本小児神経学会学術集会 2018年 公開講演,セミナー,チュートリアル,講習,講義等
  • 【主訴に沿う:俯瞰し収束する画像診断の目】 複視:主訴に沿う画像診断の目  [通常講演]
    第59回日本神経学会学術大会 2018年 公開講演,セミナー,チュートリアル,講習,講義等
  • 教育講演30 中枢神経3:遺伝と画像2  [通常講演]
    第77回日本医学放射線学会総会 2018年 公開講演,セミナー,チュートリアル,講習,講義等
  • 脳腫瘍の画像診断〜エキスパートのアプローチ〜:脳腫瘍のconventional imaging  [通常講演]
    第37回日本画像医学会 2018年 公開講演,セミナー,チュートリアル,講習,講義等
  • 脊髄腫瘍の診断:最新画像診断を使った質的診断は何処まで可能か?  [通常講演]
    第90回日本整形外科学会学術総会 2017年 シンポジウム・ワークショップパネル(指名)
  • フィルムリーディング  [通常講演]
    第46回日本神経放射線学会 2017年 シンポジウム・ワークショップパネル(指名)
  • 脊椎・肋骨の奇形  [通常講演]
    第28回骨軟部放射線診断セミナー 2017年 公開講演,セミナー,チュートリアル,講習,講義等
  • 撮像法の原理?:アーチファクト  [通常講演]
    第39回磁気共鳴学会講座 2017年 公開講演,セミナー,チュートリアル,講習,講義等
  • 若年性脳血管障害(出血編)  [通常講演]
    第59回日本小児神経学会学術集会 2017年 公開講演,セミナー,チュートリアル,講習,講義等
  • 頭部CTの基本  [通常講演]
    第13回臨床研修医のための画像診断セミナー 2017年 公開講演,セミナー,チュートリアル,講習,講義等
  • 教育講演 中枢神経3:血管関連疾患3 妊娠分娩関連  [通常講演]
    第76回日本医学放射線学会総会 2017年 公開講演,セミナー,チュートリアル,講習,講義等
  • 「エキスパートの診断過程を学ぶ中枢神経の画像診断」論理的とはどういうことか?  [通常講演]
    第46回日本神経放射線学会 2017年 公開講演,セミナー,チュートリアル,講習,講義等
  • シンポジウム2:画像診断レポート 私はこう書き(たかった)こう伝えた(かった)  [通常講演]
    第52回日本医学放射線学会秋季臨床大会 2016年 シンポジウム・ワークショップパネル(指名)
  • 認知症 〜診断と治療の未来〜 ≪形態診断≫形態診断から見た認知症画像診断  [通常講演]
    第44回日本磁気共鳴医学会大会 2016年 公開講演,セミナー,チュートリアル,講習,講義等
  • 若年性脳血管障害  [通常講演]
    第58回日本小児神経学会学術集会 2016年 公開講演,セミナー,チュートリアル,講習,講義等
  • 中枢神経2:脊髄の高信号病変  [通常講演]
    第35回日本画像医学会 2016年 公開講演,セミナー,チュートリアル,講習,講義等
  • 「画像に見えないものを診る」1.脳・脊髄  [通常講演]
    第450回日本医学放射線学会関東地方会定期大会 2016年 公開講演,セミナー,チュートリアル,講習,講義等
  • 特別企画【過去発表例の画像・病理関連】 I-cell病(mucolipidosis II)の画像:髄鞘化遅延  [通常講演]
    第10回小児神経放射線研究会 2015年 シンポジウム・ワークショップパネル(指名)
  • 神経皮膚症候群と脳血管障害  [通常講演]
    第57回日本小児神経学会学術集会 2015年 公開講演,セミナー,チュートリアル,講習,講義等
  • 小児神経疾患における画像検査に関する最新知見  [通常講演]
    第26回日本小児神経学会中国四国地方会 2015年 公開講演,セミナー,チュートリアル,講習,講義等
  • イメージインタープリテーション  [通常講演]
    第27回頭頸部放射線研究会 2014年 シンポジウム・ワークショップパネル(指名)
  • イブニングセミナー【神経画像診断塾】  [通常講演]
    第37回日本脳神経CI学会総会 2014年 シンポジウム・ワークショップパネル(指名)
  • 小児頭部画像の基本  [通常講演]
    第8回東海地区小児神経セミナー 2014年 公開講演,セミナー,チュートリアル,講習,講義等
  • 連想画像診断−画像に見えないものを診る  [通常講演]
    2014年ミッドサマーセミナー 2014年 公開講演,セミナー,チュートリアル,講習,講義等
  • MS,ADEM,CIS,NMOの画像診断  [通常講演]
    第56回日本小児神経学会学術集会実践教育セミナー 2014年 公開講演,セミナー,チュートリアル,講習,講義等
  • 中枢神経  [通常講演]
    第73回日本医学放射線学会総会 2014年 公開講演,セミナー,チュートリアル,講習,講義等
  • 脊髄:非腫瘍性疾患  [通常講演]
    第43回日本神経放射線学会 2014年 公開講演,セミナー,チュートリアル,講習,講義等
  • 注意したい画像診断のピットフォール:頭部編  [通常講演]
    第122回日本医学放射線学会中国・四国地方会 2014年 公開講演,セミナー,チュートリアル,講習,講義等
  • イメージインタープリテーション  [通常講演]
    第26回頭頸部放射線研究会 2013年 シンポジウム・ワークショップパネル(指名)
  • 脳血管障害の画像診断と治療:画像診断  [通常講演]
    第49回日本医学放射線学会秋季臨床大会 2013年 公開講演,セミナー,チュートリアル,講習,講義等
  • 認知症の形態画像診断  [通常講演]
    第7回画像診断・病診連携懇話会(生涯教育講座・学術講演会) 2013年 公開講演,セミナー,チュートリアル,講習,講義等
  • 脳幹,小脳病変の画像診断  [通常講演]
    第55回日本小児神経学会学術集会 2013年 公開講演,セミナー,チュートリアル,講習,講義等
  • 画像診断のプロセス入門(Case-based presentation):1. 中枢神経  [通常講演]
    第72回日本医学放射線学会総会 2013年 公開講演,セミナー,チュートリアル,講習,講義等
  • スクリーニング検査に必要とされる画像とは  [通常講演]
    第69回日本放射線技術学会総会学術大会 2013年 公開講演,セミナー,チュートリアル,講習,講義等
  • 症状からせまる画像診断  [通常講演]
    第42回神経放射線学会 2013年 公開講演,セミナー,チュートリアル,講習,講義等
  • 認知症における画像診断の役割  [通常講演]
    第21回造影剤と放射線シンポジウム(CMRS) 2012年 シンポジウム・ワークショップパネル(指名)
  • 「知っておきたい認知症の画像診断」5. 正常圧水頭症を見落とさないために  [通常講演]
    第71回日本医学放射線学会総会 2012年 シンポジウム・ワークショップパネル(指名)
  • 小児診療から成人診療移行期の画像診断とそのPitfall:神経領域  [通常講演]
    2012年ミッドサマーセミナー 2012年 公開講演,セミナー,チュートリアル,講習,講義等
  • 脳神経:良悪性の鑑別  [通常講演]
    第8回臨床研修医のための画像診断セミナー 2012年 公開講演,セミナー,チュートリアル,講習,講義等
  • 発達をふまえた正常画像とその読み方  [通常講演]
    第54回日本小児神経学会学術集会 2012年 公開講演,セミナー,チュートリアル,講習,講義等
  • 教育セミナー1:脳動脈瘤と血管奇形  [通常講演]
    第35回日本脳神経CI学会 2012年 公開講演,セミナー,チュートリアル,講習,講義等
  • 連続根幹セミナー? 基本の総ざらい:MRI 2.読影の基本?脊椎脊髄:ヘルニアを中心に  [通常講演]
    第31回日本画像医学会 2012年 公開講演,セミナー,チュートリアル,講習,講義等
  • 感染症の画像診断1.中枢神経系の感染症:健常者  [通常講演]
    平成23年度日本医学放射線学会関東地方会冬季セミナー 2012年 公開講演,セミナー,チュートリアル,講習,講義等
  • 頭部画像のABC  [通常講演]
    第9回日本小児神経放射線学会教育セミナー 2012年 公開講演,セミナー,チュートリアル,講習,講義等
  • ミニレクチャー1:先天代謝異常の画像診断  [通常講演]
    第6回小児神経放射線研究会 2011年 公開講演,セミナー,チュートリアル,講習,講義等
  • 画像診断教育講演9:脳-認知症  [通常講演]
    第51回日本核医学会学術総会 2011年 公開講演,セミナー,チュートリアル,講習,講義等
  • 骨髄疾患のMRI  [通常講演]
    第39回日本磁気共鳴医学会大会 2011年 公開講演,セミナー,チュートリアル,講習,講義等
  • <症候・疾患と検査・診断>頭部MRI  [通常講演]
    第41回小児神経学セミナー 2011年 公開講演,セミナー,チュートリアル,講習,講義等
  • 「もう間違えない! 悪性と良性の違い」:脳神経  [通常講演]
    第439回日本医学放射線学会関東地方会定期大会 2011年 公開講演,セミナー,チュートリアル,講習,講義等
  • 脳神経:日常診療のピットフォール  [通常講演]
    第7回前期臨床研修医のための画像診断セミナー 2011年 公開講演,セミナー,チュートリアル,講習,講義等
  • 先天代謝異常の画像診断  [通常講演]
    第53回日本小児神経学会学術集会 2011年 公開講演,セミナー,チュートリアル,講習,講義等
  • ?. 全身疾患と画像:脊椎・脊髄  [通常講演]
    平成22年度日本医学放射線学会関東地方会冬季セミナー 2011年 公開講演,セミナー,チュートリアル,講習,講義等
  • セッション4 大脳白質病変 ミニレクチャー:多発性硬化症と急性散在性脳脊髄炎の画像の違い  [通常講演]
    第53回小児神経学会関東地方会 2011年 公開講演,セミナー,チュートリアル,講習,講義等
  • 神経放射線診断における脳核医学の役割  [通常講演]
    第50会日本核医学会学術総会 2010年 シンポジウム・ワークショップパネル(指名)
  • イメージインタープリテーション:Wegener肉芽腫症  [通常講演]
    第29回日本画像医学会 2010年 シンポジウム・ワークショップパネル(指名)
  • 脊椎疾患:日常診療の読影のポイント1)変性疾患  [通常講演]
    2010年ミッドサマーセミナー 2010年 公開講演,セミナー,チュートリアル,講習,講義等
  • 教育講演?. MRIの基礎:2. 拡散画像の基礎  [通常講演]
    第29回日本画像医学会 2010年 公開講演,セミナー,チュートリアル,講習,講義等
  • 森墾, 柳下章, 石亀慶一, 久保田暁, 林俊宏, 沖山亮一
    日本神経放射線学会プログラム・抄録集 2009年
  • 指定発言:reversible posterior leukoencephalopathy syndromeの画像所見  [通常講演]
    第564回日本小児科学会東京都地方会講話会 2009年 シンポジウム・ワークショップパネル(指名)
  • ミニレクチャー:小児脊椎脊髄のMRI  [通常講演]
    第4回小児神経放射線研究会 2009年 公開講演,セミナー,チュートリアル,講習,講義等
  • 待ったなしの画像診断:変性・感染症  [通常講演]
    第38回断層映像研究会 2009年 公開講演,セミナー,チュートリアル,講習,講義等
  • 増え続ける認知症の画像診断:形態画像の要点  [通常講演]
    第435回日本医学放射線学会関東地方会 2009年 公開講演,セミナー,チュートリアル,講習,講義等
  • 教育講演19 脳神経3:1. 硬膜内  [通常講演]
    第68回日本医学放射線学会学術総会 2009年 公開講演,セミナー,チュートリアル,講習,講義等
  • 森墾, 前田理恵子, 増本智彦, 高橋美和子, 萩野昇, 平山昭, 野崎敦, 山本一彦, 百瀬敏光, 大友邦
    日本医学放射線学会総会抄録集 2008年02月
  • 神経放射線 早朝カンファレンス あなたはどう考える 二人のエクスパートが答える.  [通常講演]
    第37回日本神経放射線学会 2008年 シンポジウム・ワークショップパネル(指名)
  • 大脳白質の脳機能画像−オーバービュー− 拡散テンソル画像  [通常講演]
    第49回日本神経学会総会 2008年 シンポジウム・ワークショップパネル(指名)
  • Case-based Review 6: 脊髄・脊椎  [通常講演]
    第28回神経放射線ワークショップ 2008年 公開講演,セミナー,チュートリアル,講習,講義等
  • 拡散テンソルトラクトグラフィーを用いた神経走行の画像診断画像  [通常講演]
    第50回神経内科懇話会 2007年 公開講演,セミナー,チュートリアル,講習,講義等
  • 頭蓋頸椎移行部疾患  [通常講演]
    第41回日本医学放射線学会秋季臨床大会 2005年 公開講演,セミナー,チュートリアル,講習,講義等
  • 免疫と神経  [通常講演]
    第23回神経放射線ワークショップ 2003年 公開講演,セミナー,チュートリアル,講習,講義等
  • Investigation of patients with spinocerebellar degeneration using diffusion-tensor MRI  [通常講演]
    H Mori, K Ishigame, A Yagishita, S Aoki, O Abe, N Hayashi
  • Diffusion tensor imaging of cerebral infarction: Analysis of ADC and DTI scalar metrics (fractional anisotropy and eigenvalues)  [通常講演]
    T Yoshikawa, S Aoki, Y Masutani, O Abe, H Mori, K Ohtomo
  • Feasibility of intraarterial MRDSA in a MRI-IVR system  [通常講演]
    T Masumoto, N Hayashi, H Mori, O Abe, S Aoki, K Ohtomo
  • 2D MRDSA using ASSET  [通常講演]
    H Mori, S Aoki, T Okubo, T Masumoto, K Ohtomo, H Kabasawa
  • Feasibility of combined DSA/MRI-guided sclerotherapy for soft tissue hemangioma: Preliminary experience with 14 procedures in five patients  [通常講演]
    T Masumoto, N Hayashi, H Mori, T Yoshikawa, S Aoki, K Ohtomo



  • 神経放射線
  • neuroradiology


  • 2021年   日本磁気共鳴医学会   代議員
  • 2019年   日本画像医学会   評議員
  • 2018年   日本医学放射線学会   代議員
  • 2009年   日本神経放射線学会   評議員   日本神経放射線学会

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