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坂下 英司 サカシタ エイジ

所属部署名生化学講座機能生化学部門
職名講師ホームページURL

プロフィール

研究キーワード

    スプライシング因子, RNA結合タンパク質, 熱ショック, 核スペックル, SRタンパク質, ATP合成酵素

研究分野

  • 基礎医学 / 医化学一般

経歴

  • 2007年
    -
    現在
    自治医科大学 医学部(講師)

学位

  • 理学博士

研究活動

論文

  • Developmentally Regulated RNA-binding Protein 1 (Drb1)/RNA-binding Motif Protein 45 (RBM45), a Nuclear-Cytoplasmic Trafficking Protein, Forms TAR DNA-binding Protein 43 (TDP-43)-mediated Cytoplasmic Aggregates.
    Mashiko T, Sakashita E, Kasashima K, Tominaga K, Kuroiwa K, Nozaki Y, Matsuura T, Hamamoto T, Endo H
    The Journal of biological chemistry 291(29) 14996-15007 2016年07月
  • Paraneoplastic cerebellar degeneration associated with an onconeural antibody against creatine kinase, brain-type.
    Tetsuka S, Tominaga K, Ohta E, Kuroiwa K, Sakashita E, Kasashima K, Hamamoto T, Namekawa M, Morita M, Natsui S, Morita T, Tanaka K, Takiyama Y, Nakano I, Endo H
    Journal of the neurological sciences 335(1-2) 48-57 2013年12月
  • Translational repression of the McKusick-Kaufman syndrome transcript by unique upstream open reading frames encoding mitochondrial proteins with alternative polyadenylation sites.
    Akimoto C, Sakashita E, Kasashima K, Kuroiwa K, Tominaga K, Hamamoto T, Endo H
    Biochimica et biophysica acta 1830(3) 2728-2738 2013年03月
  • SR and SR-related proteins redistribute to segregated fibrillar components of nucleoli in a response to DNA damage.
    Sakashita E, Endo H
    Nucleus (Austin, Tex.) 1(4) 367-380 2010年07月
  • Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.
    Trembley JH, Tatsumi S, Sakashita E, Loyer P, Slaughter CA, Suzuki H, Endo H, Kidd VJ, Mayeda A
    Molecular and cellular biology 25(4) 1446-1457 2005年02月
  • Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.
    Sakashita E, Tatsumi S, Werner D, Endo H, Mayeda A
    Molecular and cellular biology 24(3) 1174-1187 2004年02月
  • Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins.
    Kasashima K, Sakashita E, Saito K, Sakamoto H
    Nucleic acids research 30(20) 4519-4526 2002年10月
  • cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein.
    Tamada H, Sakashita E, Shimazaki K, Ueno E, Hamamoto T, Kagawa Y, Endo H
    Biochemical and biophysical research communications 297(1) 96-104 2002年09月
  • Muscle-specific exonic splicing silencer for exon exclusion in human ATP synthase gamma-subunit pre-mRNA.
    Hayakawa M, Sakashita E, Ueno E, Tominaga S, Hamamoto T, Kagawa Y, Endo H
    The Journal of biological chemistry 277(9) 6974-6984 2002年03月
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  • Developmentally Regulated RNA-binding Protein 1 (Drb1)/RNA-binding Motif Protein 45 (RBM45), a Nuclear-Cytoplasmic Trafficking Protein, Forms TAR DNA-binding Protein 43 (TDP-43)-mediated Cytoplasmic Aggregates.
    Mashiko T, Sakashita E, Kasashima K, Tominaga K, Kuroiwa K, Nozaki Y, Matsuura T, Hamamoto T, Endo H
    The Journal of biological chemistry 291(29) 14996-15007 2016年07月
  • Paraneoplastic cerebellar degeneration associated with an onconeural antibody against creatine kinase, brain-type.
    Tetsuka S, Tominaga K, Ohta E, Kuroiwa K, Sakashita E, Kasashima K, Hamamoto T, Namekawa M, Morita M, Natsui S, Morita T, Tanaka K, Takiyama Y, Nakano I, Endo H
    Journal of the neurological sciences 335(1-2) 48-57 2013年12月
  • Translational repression of the McKusick-Kaufman syndrome transcript by unique upstream open reading frames encoding mitochondrial proteins with alternative polyadenylation sites.
    Akimoto C, Sakashita E, Kasashima K, Kuroiwa K, Tominaga K, Hamamoto T, Endo H
    Biochimica et biophysica acta 1830(3) 2728-2738 2013年03月
  • SR and SR-related proteins redistribute to segregated fibrillar components of nucleoli in a response to DNA damage.
    Sakashita E, Endo H
    Nucleus (Austin, Tex.) 1(4) 367-380 2010年07月
  • Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.
    Trembley JH, Tatsumi S, Sakashita E, Loyer P, Slaughter CA, Suzuki H, Endo H, Kidd VJ, Mayeda A
    Molecular and cellular biology 25(4) 1446-1457 2005年02月
  • Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.
    Sakashita E, Tatsumi S, Werner D, Endo H, Mayeda A
    Molecular and cellular biology 24(3) 1174-1187 2004年02月
  • Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins.
    Kasashima K, Sakashita E, Saito K, Sakamoto H
    Nucleic acids research 30(20) 4519-4526 2002年10月
  • cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein.
    Tamada H, Sakashita E, Shimazaki K, Ueno E, Hamamoto T, Kagawa Y, Endo H
    Biochemical and biophysical research communications 297(1) 96-104 2002年09月
  • Muscle-specific exonic splicing silencer for exon exclusion in human ATP synthase gamma-subunit pre-mRNA.
    Hayakawa M, Sakashita E, Ueno E, Tominaga S, Hamamoto T, Kagawa Y, Endo H
    The Journal of biological chemistry 277(9) 6974-6984 2002年03月


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