研究者総覧

五味 玲 (ゴミ アキラ)

  • 小児脳神経外科 教授
Last Updated :2022/09/25

研究者情報

学位

  • 博士(医学)(自治医科大学(JMU))

ホームページURL

J-Global ID

研究キーワード

  • 小児脳神経外科   分子生物学   脳神経外科学   Molecular Biology   Neurosurgery   

研究分野

  • ライフサイエンス / 脳神経外科学
  • ライフサイエンス / 分子生物学

学歴

  •         - 1995年   自治医科大学(JMU)   医学研究科   脳神経外科学
  •         - 1995年   自治医科大学   Graduate School, Division of Medicine
  •         - 1984年   自治医科大学(JMU)   医学部   医学科
  •         - 1984年   自治医科大学   Faculty of Medicine

所属学協会

  • 日本神経内視鏡学会   日本小児血液がん学会   日本小児脳神経外科学会   日本脳腫瘍学会   日本脳腫瘍病理学会   日本癌学会   日本脳神経外科学会   

研究活動情報

論文

  • Yoko T. Katsuragi, Akira Gomi, Ataru Sunaga, Kunio Miyazaki, Hideaki Kamochi, Fumihiro Arai, Noriyoshi Fukushima, Yasushi Sugawara
    JOURNAL OF NEUROSURGERY-PEDIATRICS 12 6 622 - 625 2013年12月 [査読有り][通常論文]
     
    Numerous reports have demonstrated the usefulness of bioresorbable materials, but few have described severe complications caused by delayed degradation. The authors present the case of an intracranial foreign body granuloma caused by plates made of unsintered hydroxyapatite (uHA) particles and poly-L-lactide (PLLA; Super Fixsorb MX, Takiron) after cranioplasty. This 1-month-old boy presented to the authors' department with Pfeiffer syndrome. He had multiple-suture synostosis causing turribrachycephaly, Chiari malformation Type 1, and obstructive sleep apnea syndrome. At 6 months old, the child was treated with multidirectional cranial distraction osteogenesis. The uHA-PLLA plates were applied as base stones to reinforce the pins. After 16 days of distraction and 3 weeks of consolidation, the pins were removed. Seventeen months postoperatively, the plate on the right temporal bone showed passive intraosseous translocation (PIT), and by 2 years postoperatively, the plate was completely left behind in the cerebrum. At 3.5 years postoperatively, MRI disclosed a contrast-enhanced mass with surrounding brain edema at the site of the plate. The lesion was resected. The clinical history and histological specimens led to a diagnosis of foreign body granuloma surrounding the nonabsorbed resorbable plate in the dura mater. Resorbable plates are clearly useful resources in cases in which delayed absorption will not prove problematic, but careful application and follow-up is required when dealing with the growing skull given the possibility of intracranial displacement after PIT.
  • Satsuki Miyata, Masashi Urabe, Akira Gomi, Mutsumi Nagai, Takashi Yamaguchi, Tomonori Tsukahara, Hiroaki Mizukami, Akihiro Kume, Keiya Ozawa, Eiju Watanabe
    NEUROLOGIA MEDICO-CHIRURGICA 53 10 645 - 654 2013年10月 [査読有り][通常論文]
     
    Cytosolic isocitrate dehydrogenase 1 (IDH1) with an R132H mutation in brain tumors loses its enzymatic activity for catalyzing isocitrate to alpha-ketoglutarate (alpha-KG) and acquires new activity whereby it converts alpha-KG to 2-hydroxyglutarate. The IDH1 mutation induces down-regulation of tricarboxylic acid cycle intermediates and up-regulation of lipid metabolism. Sterol regulatory element-binding proteins (SREBPs) regulate not only the synthesis of cholesterol and fatty acids but also acyclin-dependent kinase inhibitor p21 that halts the cell cycle at G1. Here we show that SREBPs were up-regulated in U87 human glioblastoma cells transfected with an IDH1(R132H)-expression plasmid. Small interfering ribonucleic acid (siRNA) for SREBP1 specifically decreased p21 messenger RNA (mRNA) levels independent of the p53 pathway. In IDH1(R132H)-expressing U87 cells, phosphorylation of Retinoblastoma (Rb) protein also decreased. We propose that metabolic changes induced by the IDH1 mutation enhance p21 expression via SREBP1 and inhibit phosphorylation of Rb, which slows progression of the cell cycle and may be associated with non-aggressive features of gliomas with an IDH1 mutation.
  • Akira Gomi, Hirofumi Oguma, Rieko Furukawa
    CHILDS NERVOUS SYSTEM 29 9 1641 - 1645 2013年09月 [査読有り][通常論文]
     
    This study aims to ascertain which specific types of sacrococcygeal dimples are associated with underlying spinal cord malformations. From 2008 to 2011, we prospectively examined children less than 2 years old with sacrococcygeal dimples. Each patient underwent clinical assessment of dimples and magnetic resonance imaging. We devised the following new classification of dimples according to their location: type 1, dimples located within the gluteal crease, including coccygeal pits; type 2, dimples located at the upper edge of the gluteal crease with associated curving or deformity of that crease; and type 3, dimples located well above the gluteal crease. We evaluated 142 patients with sacrococcygeal dimples. Although we identified spinal malformations such as spinal lipomas, filum cysts, and thickened fila terminalia in only 17 % of infants with type 1 dimples, we observed them in 45 % with type 2 and 55 % with type 3. Thus, in terms of the rate of spinal malformations, there are significant differences between types 1 and 2 and between types 1 and 3. We propose a new classification of sacrococcygeal dimples. Although type 2 dimples have previously been classified as simple dimples that require no further investigation, we have identified that they are strongly associated with spinal deformities, comparable to atypical type 3 dimples. Thus, both types 2 and 3 dimples warrant radiological investigation.
  • Matsubara S, Usui R, Koike Y, Gomi A
    Archives of gynecology and obstetrics 287 3 617 - 618 3 2013年03月 [査読有り][通常論文]
  • 田中 聡, 田代 隆, 小野崎 聡, 高梨 淳子, 五味 玲, 氏家 弘
    脊髄外科 : 日本脊髄外科研究会機関誌 = Spinal surgery : official journal of the Japanese Society of Spinal Surgery 26 1 52 - 59 2012年04月 [査読無し][通常論文]
  • Kimura Y, Seichi A, Gomi A, Kojima M, Inoue H, Kimura A
    Neurologia medico-chirurgica 52 9 683 - 686 9 2012年 [査読有り][通常論文]
  • Akira Gomi
    Neurological Surgery 39 3 295 - 304 2011年03月 [査読有り][通常論文]
  • Tanaka S, Tashiro T, Gomi A, Takanashi J, Ujiie H
    Surgical neurology international 2 111  2011年 [査読有り][通常論文]
  • Tanaka S, Tashiro T, Gomi A, Ujiie H
    Neurologia medico-chirurgica 51 9 673 - 677 9 2011年 [査読有り][通常論文]
  • Satsuki Miyata, Akira Gomi, Takashi Yamaguchi, Yuichi Tanaka, Eiju Watanabe, Akira Tanaka
    BRAIN TUMOR PATHOLOGY 27 1 45 - 50 2010年04月 [査読有り][通常論文]
     
    A case of unclassified, pediatric cerebral neuroepithelial tumor in a 10-year-old girl that showed remarkable radiosensitivity is reported. MRI revealed a brain tumor of mixed intensity with heterogeneous enhancement in the medial temporal lobe, extending to the basal ganglia. The tumor was partially removed. On pathology, the main part of the tumor showed immature features: the tumor cells had a chromatin-rich large nucleus and less cytoplasm, and mitoses and fragmentation of the nuclei were frequent. On immunohistochemistry, the tumor cells were negative for glial fibrillary acidic protein (GFAP) and synaptophysin and positive for Olig2. The maximum MIB-1 index was 70%. The part invading into the surrounding brain showed similarities in form to a highly anaplastic astrocytoma. The infiltrating tumor cells were positive for GFAP and less positive for Olig2. After 40 Gy radiation, the residual tumor was markedly reduced. Neuroepithelial tumors rarely show such high radiosensitivity, and the reason for the radiosensitivity in the present case may have been the immaturity of the tumor cells.
  • 菅原 康志, 宇田 宏一, 去川 俊二, 須永 中, 五味 玲
    脳神経外科ジャーナル 19 4 280 - 285 日本脳神経外科コングレス 2010年 [査読無し][通常論文]
     
    われわれは,2003年より頭蓋縫合早期癒合症に対し,外固定型の骨延長装置を用いた治療法,Multidirectional Cranial Distraction Ostegenesis(MCDO)法を行っている.これまで行った23症例を検討した結果,内固定型に比べ形態の改善度に勝り,装置除去時の手術侵襲の軽減が得られた.また初回手術の侵襲,合併症の軽減,延長期間の短縮も計られたことから,MCDO法は骨延長法の適応の拡大に寄与する優れた術式と考えられる.
  • 菅原 康志, 宇田 宏一, 去川 俊二, 須永 中, 五味 玲
    小児の脳神経 34 4 336 - 340 2009年08月 [査読無し][通常論文]
  • 菅原 康志, 宇田 宏一, 去川 俊二, 須永 中, 五味 玲
    脳神経外科ジャーナル 18 0 54 - 54 日本脳神経外科コングレス 2009年04月 [査読無し][通常論文]
  • Transient Induction of the MRP/GS-X Pump and γ-Glutamylcysteine Syntherase by 1-(4-Amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea-in Human Glioma Cells
    Cancer Research 57, 5292 1997年 [査読無し][通常論文]
  • Elevated Expression of DNA Polymerase β Gene in Glioma Cell Lines with Acquired Resistance to 1-(4-Amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea
    Biochem Biophys Res Comm 227, 558 1996年 [査読無し][通常論文]
  • Freguent Loss of the cyclin-dependent kinase-4 Inhibitor Gene in Human Gliomas
    Japanese Journal of cancer Research 86(4), 342 1995年 [査読無し][通常論文]
  • Ultrastructural study of Glossopharyngeal Neurinoma
    Journal of Clinical Electorn Microscopy 23(2), 195 1990年 [査読無し][通常論文]

書籍

MISC

共同研究・競争的資金等の研究課題

  • 脳腫瘍の分子生物学
    遺伝子科学研究
    研究期間 : 1988年
  • Molecular Biology of Brain Tumors
    Gene Science Research
    研究期間 : 1988年


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