研究者総覧

遠藤 俊輔 (エンドウ シュンスケ)

  • さいたま医療センター さいたま医療センター長
メールアドレス: tcvshunjichi.ac.jp
Last Updated :2020/07/29

研究者情報

学位

  • 医学博士(自治医科大学(JMU))

学位

    遠藤 俊輔

J-Global ID

プロフィール

  • 1984年 筑波大学医学専門学群卒業 同病院外科レジデント

    1989年 カナダ マギール大学実験医学研究部門研究員

    大動脈内の血流解析 博士論文取得

    1992年 自治医科大学胸部外科助手

    1998年 宇都宮社会保険病院呼吸器外科科長

    2000年 自治医科大学呼吸器外科講師

    2004年 自治医科大学呼吸器外科助教授

    2005年 自治医科大学附属さいたま医療センター呼吸器外科助教授

    2008年4月 自治医科大学附属さいたま医療センター呼吸器外科教授

    2008年10月 自治医科大学外科学講座呼吸器外科部門

    兼 附属さいたま医療センター呼吸器外科 教授




    所属学会 評議員

    日本外科学会 代議員 将来計画委員 邦文誌編集委員

    日本胸部外科学会評議員 学術部会委員

    日本呼吸器外科学会 評議員 理事

    日本呼吸器内視鏡学会 評議員

    日本呼吸器学会 代議員 専門医試験委員

    日本肺癌学会 評議員 X線検診部会委員

    日本内視鏡外科学会評議員 学術委員

    NCD 運営委員

    Annals of Cardivascular Surgeon Editorial board

研究キーワード

  • (胸部呼吸器)外科学   Thoracic Surgery   

研究分野

  • ライフサイエンス / 呼吸器外科学
  • ライフサイエンス / 心臓血管外科学

経歴

  • 2000年  - 自治医科大学 胸部外科学 講師
  • 2000年  -
  • 1992年 - 1998年  自治医科大学 胸部外科学 助手
  • 1989年 - 1992年  マギール大学(カナダ)実験医学研究部門研究員
  • 1989年 - 1992年  post doctoral research fellow
  • 自治医科大学(JMU)教授

学歴

  •         - 1984年   筑波大学   医学部   医学
  •         - 1984年   筑波大学   Faculty of Medicine

所属学協会

  • 日本肺癌学会   日本呼吸器内視鏡学会   日本呼吸器外科学会   日本胸部外科学会   日本外科学会   

研究活動情報

書籍

  • Effect of high blood flow on granulocyte-endothelium adhesion in the reperfusion rat lung
    ()
    Microcirculation annual 1995 1995年
  • Vital observation of pulmonary microcirculation at acute phase in transplanted rat lungs
    ()
    Microcirculation Annual 1993. 1993年
  • Connection between bronchial circulation and pulmonary circulation
    ()
    Microcirculation annual 1992 1992年

MISC

  • S Endo, Y Sakuma, Y Sato, Y Sohara EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 26 (5) 1042 -1042 2004年11月 [査読無し][通常論文]
  • S Endo, T Yamaguchi, N Saito, S Otani, T Hasegawa, Y Sato, Y Sohara ANNALS OF THORACIC SURGERY 77 (5) 1745 -1750 2004年05月 [査読無し][通常論文]
     
    Background. The benefit of thymectomy in myasthenia gravis management is recognized but the perioperative course can fluctuate. The goal of this study was to assess the feasibility and clinical benefit of dose-escalated steroid therapy with thymectomy for nonthymornatous myasthenia gravis. Methods. We reviewed the records of 69 myasthenia gravis patients who were followed up after undergoing transsternal thymectomy with extended anterior mediastinal dissection in our hospital between 1976-2000. Forty-eight patients in the programmed treatment group who had dose-escalated and de-escalated steroid therapy during the perioperative period comprised 17 patients with ocular myasthenia gravis and 31 patients with generalized myasthenia gravis. Clinical benefits and clinical remission, which was diagnosed when the patients were symptom-free without medications for at least 1 year, were compared with those of 21 patients in the occasional treatment group who received medications occasionally over the perioperative period. Results. Postoperative respiratory failure and myasthenic crisis did not occur in the programmed treatment group but did occur in 6 patients in the occasional treatment group. Remission rates in the programmed treatment group (mean follow-up, 6.4 years) were 30% at 3 years, 38% at 5 years, and 46% at 10 years; rates in the occasional treatment group (mean follow-up, 9.6 years) were 25% at 3 years, 25% at 5 years, and 45% at 10 years. Conclusions. Programmed steroid therapy in patients with nonthymomatous myasthenia gravis is feasible and it provides clinical benefit when fluctuating symptoms occur during the perioperative period.
  • S Endo, T Yamaguchi, N Saito, S Otani, T Hasegawa, Y Sato, Y Sohara ANNALS OF THORACIC SURGERY 77 (5) 1745 -1750 2004年05月 [査読無し][通常論文]
     
    Background. The benefit of thymectomy in myasthenia gravis management is recognized but the perioperative course can fluctuate. The goal of this study was to assess the feasibility and clinical benefit of dose-escalated steroid therapy with thymectomy for nonthymornatous myasthenia gravis. Methods. We reviewed the records of 69 myasthenia gravis patients who were followed up after undergoing transsternal thymectomy with extended anterior mediastinal dissection in our hospital between 1976-2000. Forty-eight patients in the programmed treatment group who had dose-escalated and de-escalated steroid therapy during the perioperative period comprised 17 patients with ocular myasthenia gravis and 31 patients with generalized myasthenia gravis. Clinical benefits and clinical remission, which was diagnosed when the patients were symptom-free without medications for at least 1 year, were compared with those of 21 patients in the occasional treatment group who received medications occasionally over the perioperative period. Results. Postoperative respiratory failure and myasthenic crisis did not occur in the programmed treatment group but did occur in 6 patients in the occasional treatment group. Remission rates in the programmed treatment group (mean follow-up, 6.4 years) were 30% at 3 years, 38% at 5 years, and 46% at 10 years; rates in the occasional treatment group (mean follow-up, 9.6 years) were 25% at 3 years, 25% at 5 years, and 45% at 10 years. Conclusions. Programmed steroid therapy in patients with nonthymomatous myasthenia gravis is feasible and it provides clinical benefit when fluctuating symptoms occur during the perioperative period.
  • 喀血症例に対する手術療法
    気管支学 2004年 [査読無し][通常論文]
  • 末梢小型肺癌の――
    胸部外科 57 L143-L148 2004年 [査読無し][通常論文]
  • Eur J Cardiothoracic Surg 26 787 -791 2004年 [査読無し][通常論文]
  • S Endo, S Otani, N Saito, T Hasegawa, Y Kanai, Y Sato, Y Sohara EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 23 (4) 467 -472 2003年04月 [査読無し][通常論文]
     
    Objective: Massive hemoptysis is a life-threatening condition. Surgery is effective but we are sometimes reluctant to operate on patients with this condition. We reviewed our experience with patients who underwent emergency surgery for massive hemoptysis to verify the indications for non-emergency surgical intervention. Methods: We reviewed chest computed tomography (CT) and angiographic and pathological findings and the postoperative course of 25 patients who underwent emergency pulmonary resection in our department between 1979 and 2001 due to life-threatening hemoptysis. Results: CT revealed a persistent cavity within the radiological opacity before massive hemoptysis in 12 patients (48%). Of the 21 patients who underwent angiography, nine showed focal bleeding in one bronchial branch and the others showed bleeding in multiple branches. Of these nine patients, seven did not undergo embolotherapy mainly due to minor vascularity. In the remaining patients, embolotherapy was not indicated in six due to multiple bleeding feeders and recurrence after embolotherapy was seen in six. Pathological findings showed that eight of the 12 patients with multiple systemic shunts had a fungal infection. Operative morbidity and hospital mortality were 32 and 4%, respectively. There was no recurrence in patients who underwent surgical treatment. Conclusions: Early pulmonary resection is indicated in patients with hemoptysis of multiple branches from the cavity and chest wall, such as in fungal infections. When a bronchial branch is the only bleeding focus, superselective embolotherapy should be considered prior to surgery even if the localized focus of the bronchial branch shows minor vascularity on the angiography. (C) 2003 Elsevier Science B.V. All rights reserved.
  • S Endo, Y Sohara, F Murayama, T Yamaguchi, T Hasegawa, Y Kanai SURGERY 133 (2) 207 -215 2003年02月 [査読無し][通常論文]
     
    Background. To clarify the effects of partial liquid ventilation, we visualized and morphologically analyzed real-time alveolar recruitment. in a model of acute lung injury. Methods. Male Wistar rats were divided into 3 groups: a group that underwent hydrochloric acid aspiration and mechanical gas ventilation (ALI group, n = 15), a group that underwent acid aspiration and partial liquid ventilation beginning 90 minutes after acid aspiration (PLV group, n = 15), and a group that underwent mechanical ventilation without acid aspiration (control group, n = 5). The number of ventilated alveoli and the diameter of the largest ventilated alveolus in each of 10 high-power fields observed on fluorescence micrographs with a tracer of labeled albumin were determined and averaged from 90 to 210 minutes after acid aspiration. Results. The number of alveoli in the PLV group significantly increased in comparison to that in the ALI group. The diameter of the largest alveolus in the PLV group decreased from 103.7 +/- 16.3 mum to 76.3 +/- 6.5 mug in until the end of the experiment. This diameter was equivalent to that in the control group. Conclusions. The excellent alveolar recruitment suggests that liquid ventilation ameliorates ventilator-associated lung injury.
  • S Endo, Y Sohara, F Murayama, T Yamaguchi, T Hasegawa, Y Kanai SURGERY 133 (2) 207 -215 2003年02月 [査読無し][通常論文]
     
    Background. To clarify the effects of partial liquid ventilation, we visualized and morphologically analyzed real-time alveolar recruitment. in a model of acute lung injury. Methods. Male Wistar rats were divided into 3 groups: a group that underwent hydrochloric acid aspiration and mechanical gas ventilation (ALI group, n = 15), a group that underwent acid aspiration and partial liquid ventilation beginning 90 minutes after acid aspiration (PLV group, n = 15), and a group that underwent mechanical ventilation without acid aspiration (control group, n = 5). The number of ventilated alveoli and the diameter of the largest ventilated alveolus in each of 10 high-power fields observed on fluorescence micrographs with a tracer of labeled albumin were determined and averaged from 90 to 210 minutes after acid aspiration. Results. The number of alveoli in the PLV group significantly increased in comparison to that in the ALI group. The diameter of the largest alveolus in the PLV group decreased from 103.7 +/- 16.3 mum to 76.3 +/- 6.5 mug in until the end of the experiment. This diameter was equivalent to that in the control group. Conclusions. The excellent alveolar recruitment suggests that liquid ventilation ameliorates ventilator-associated lung injury.
  • Eur J Cardiothoracic Surg 23, 467-472 2003年 [査読無し][通常論文]
  • S Endo, F Murayama, T Yamaguchi, S Yamamoto, S Otani, N Saito, Y Sohara ANNALS OF THORACIC SURGERY 74 (1) 185 -190 2002年07月 [査読無し][通常論文]
     
    Background. Diagnosis and treatment of pulmonary actinomycosis is difficult without surgical intervention. Methods. Thirteen patients (10 men, 3 women; mean age, 62 years) underwent pulmonary resection and were given a pathologic diagnosis of pulmonary actinomycosis at our institution between 1976 and 2001. To clarify when pulmonary actinomycosis should be suspected in patients and the role of surgical intervention, we reviewed preoperative clinical characteristics, computed tomography findings, surgical indication, operative procedure, postoperative clinical course, and outcome. Results. Ten patients (77%) had poor oral hygiene. Twelve patients (92%) were symptomatic, and 10 patients (77%) had hemoptysis. The mean interval between radiographic identification of the abnormality and surgical intervention was 8 months (interquartile range, 3.25 to 8 months). Computed tomography findings in all cases included radiologic opacity with air bronchogram or a low attenuation area. Lung cancer was diagnosed initially because of computed tomography findings of spiculation or pleural indentation, and operation was required in 8 patients (62%). The others were diagnosed with chronic pneumonia, and surgical intervention became necessary because of recurrent hemoptysis or prolonged illness. Six patients underwent lobectomy; the others underwent partial resection or segmentectomy. Neither complication nor recurrence has occurred. Conclusions. When patients, particularly those with poor oral hygiene, show radiologic opacity with an air bronchogram or low attenuation area on the computed tomography scan, pulmonary actinomycosis should be considered and penicillin should be administered as diagnostic therapy. Surgical intervention may be necessary when frequent hemoptysis has no resolution or lung neoplasm cannot be ruled out. (C) 2002 by The Society of Thoracic Surgeons.
  • S Endo, F Murayama, T Yamaguchi, S Yamamoto, S Otani, N Saito, Y Sohara ANNALS OF THORACIC SURGERY 74 (1) 185 -190 2002年07月 [査読無し][通常論文]
     
    Background. Diagnosis and treatment of pulmonary actinomycosis is difficult without surgical intervention. Methods. Thirteen patients (10 men, 3 women; mean age, 62 years) underwent pulmonary resection and were given a pathologic diagnosis of pulmonary actinomycosis at our institution between 1976 and 2001. To clarify when pulmonary actinomycosis should be suspected in patients and the role of surgical intervention, we reviewed preoperative clinical characteristics, computed tomography findings, surgical indication, operative procedure, postoperative clinical course, and outcome. Results. Ten patients (77%) had poor oral hygiene. Twelve patients (92%) were symptomatic, and 10 patients (77%) had hemoptysis. The mean interval between radiographic identification of the abnormality and surgical intervention was 8 months (interquartile range, 3.25 to 8 months). Computed tomography findings in all cases included radiologic opacity with air bronchogram or a low attenuation area. Lung cancer was diagnosed initially because of computed tomography findings of spiculation or pleural indentation, and operation was required in 8 patients (62%). The others were diagnosed with chronic pneumonia, and surgical intervention became necessary because of recurrent hemoptysis or prolonged illness. Six patients underwent lobectomy; the others underwent partial resection or segmentectomy. Neither complication nor recurrence has occurred. Conclusions. When patients, particularly those with poor oral hygiene, show radiologic opacity with an air bronchogram or low attenuation area on the computed tomography scan, pulmonary actinomycosis should be considered and penicillin should be administered as diagnostic therapy. Surgical intervention may be necessary when frequent hemoptysis has no resolution or lung neoplasm cannot be ruled out. (C) 2002 by The Society of Thoracic Surgeons.
  • Annals of Thoracic Surgery 72 889 -893 2001年 [査読無し][通常論文]
  • Annals of Thoracic Surgery 72 889 -893 2001年 [査読無し][通常論文]
  • Annals of Thoracic Surgery 74 926 -927 2000年 [査読無し][通常論文]
  • Annals of Thoracic Surgery 74 926 -927 2000年 [査読無し][通常論文]
  • S Endo, N Saitoh, F Murayama, Y Sohara, K Fuse ANNALS OF THORACIC SURGERY 69 (1) 262 -264 2000年01月 [査読無し][通常論文]
     
    Symptomatic accessory cardiac bronchus is rare. A 52-year-old woman with an accessory bronchus, who had had frequent episodes of hemosputum for 6 years, suffered from empyema complicated by a right lower lung abscess infected with Pseudomomas aeruginosa. Resection of the anomalous cardiac bronchus after open drainage of the pleural cavity was successful. (C) 2000 by The Society of Thoracic Surgeons.
  • S Endo, F Murayama, T Hasegawa, Y Sohara, K Fuse ANNALS OF THORACIC SURGERY 67 (3) 847 -849 1999年03月 [査読無し][通常論文]
     
    We treated a 54-year-old man with an anastomotic obstruction after a right upper sleeve lobectomy. By using minimum intensity projection images that were generated from helical computed tomographic data sets that indicated a twisted slit enhanced with air a few millimeters in length, through anastomosis to the distal bronchus, we successfully treated the obstruction by bronchoscopic balloon dilatation. (Ann Thorac Surg 1999;67:847-9) (C) 1999 by The Society of Thoracic Surgeons.
  • Guideline of Surgical management based on diffusion of descending necrotizing mediastinitis.
    Japanese Journal of Thoracic and Cardiovascular Surgery 47 14 -19 1999年 [査読無し][通常論文]
  • S Endo, Y Sohara, T Karino HEART AND VESSELS 11 (4) 180 -191 1996年 [査読無し][通常論文]
     
    To elucidate the possible connection between blood flow and localized pathogenesis and tile development of atherosclerosis in humans, we studied the flow patterns and the distribution of fluid axial velocity and wall shear stress in the aortic arch in detail, This was done by means of flow visualization and highspeed cinemicrographic techniques, using transparent aortic tries prepared from the dog, Under a steady flow condition at inflow Reynolds numbers of 700-1600, which simulated physiologic conditions at early- to mid-systole, slow, spiral secondary, and recirculation flows formed along the left anterior wall of the aortic arch and at the entrance of each side branch adjacent to the vessel wail opposite the flow divider, respectively. The flow in the aortic arch consisted of three major components, namely, an undisturbed parallel now located close to the common median plane of the arched aorta and its side branches, a clockwise rotational now formed along the left ventral wall, and the main flow to the side branches, located along the right dorsal wall of the ascending aorta, Thus, looking down the aorta from its origin, the flow in the aortic arch appeared as a single helical flow revolving in a clockwise direction, Regions of low wall shear stress were located along the leading edge of each side branch opposite the flow divider where slow recirculation flows formed, and along the left ventral wall where slow spiral secondary flows formed. If we assume that the flow patterns in the human aortic arch well resemble those observed in the dog, then it is likely that atherosclerotic lesions develop preferentially at these sites of low wall shear stress in the same manner as in human coronary and cerebral arteries.
  • MICROCIRCULATORY DISORDERS IN THE EARLY STAGES OF TRANSPLANTED RAT LUNGS
    S ENDO, Y SOHARA, F MURAYAMA, T YAMAGUCHI, T KAWASHIMA, K FUSE, T HASEGAWA TRANSPLANTATION PROCEEDINGS 26 (2) 887 -889 1994年04月 [査読無し][通常論文]

共同研究・競争的資金等の研究課題

  • 重症筋無力症の外科治療
  • 透明化血管を用いた血流の可視化の研究
  • 液体呼吸療法の開発
  • 進行肺癌に対する外科療法
  • Surgical intervention for Myasthenia Gravis
  • flow visualization study with the use of transparent vessels.
  • Liquid Ventilation
  • Surgical intervention for advanced lung cancer

委員歴

  • 2001年   日本胸部外科学会   指導医   日本胸部外科学会
  • 2000年   日本呼吸器外科学会   専門医   日本呼吸器外科学会
  • 1998年   日本呼吸器内視鏡学会   指導医   日本呼吸器内視鏡学会
  • 1984年   日本肺癌学会   会員   日本肺癌学会
  • 1983年   日本外科学会   指導医   日本外科学会


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