研究者総覧

笹沼 秀幸 (ササヌマ ヒデユキ)

  • 整形外科学講座 講師
メールアドレス: sasakoujichi.ac.jp
Last Updated :2021/11/23

研究者情報

ホームページURL

J-Global ID

研究キーワード

  • 中枢神経   骨・軟骨代謝   

研究分野

  • ライフサイエンス / 整形外科学

経歴

  • 2010年 - 2011年  自治医科大学医学部研究員

研究活動情報

論文

  • Hideyuki Sasanuma, Hitoshi Sekiya, Kenzo Takatoku, Takashi Ajiki, Hiroyoshi Hagiwara
    European Journal of Orthopaedic Surgery and Traumatology 24 8 1525 - 1530 2014年11月 [査読有り][通常論文]
     
    Purpose: In conventional total knee arthroplasty (TKA) using extramedullary alignment guides, it is not always easy to cut the proximal tibia precisely perpendicular to the tibial axis. The purpose of this study was to compare the radiographic accuracy of cutting the proximal tibia between the use of the bony landmarks of the anterior tibial border and the use of the conventional technique. Methods: A total of 173 patients underwent primary TKA. In 76 TKAs, we used the bony landmark method, and in 97 TKAs, we used the conventional method. In the bony landmark method, we set the coronal alignment in reference to the line connecting the proximal and distal one-third of the anterior tibial border, and we determined the 5° posterior slope in reference to this line. Six months postoperatively, radiological evaluations were performed using full-length standing anteroposterior and lateral radiographs of the knee. Results: No significant differences in the coronal tibial component angle were found between the groups. The posterior tilt of the tibial component was significantly smaller in the bony landmark method than in the conventional method (5.1° ± 2.9° vs. 6.4° ± 3.2°, respectively p = 0.007). The percentage of patients whose posterior tilt of the tibial component was within ±3° of 5° was significantly larger in the bony landmark method than in the conventional method (70 vs. 62 %, respectively p = 0.04). Conclusions: The bony landmark method provided a more accurate posterior tibial slope than the conventional method. However, there was no difference in coronal alignment compared with the conventional method.
  • Hideyuki Sasanuma, Hitoshi Sekiya, Kenzou Takatoku, Hisashi Takada, Naoya Sugimoto, Yuichi Hoshino
    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 19 6 921 - 925 2011年06月 [査読有り][通常論文]
     
    The objective of the present study was to compare the intraoperative use of tranexamic acid (TNA) plus intra-articular diluted-epinephrine (DEP) with preoperative autologous blood donations and transfusions in reducing an allogeneic blood transfusion (ABT) in primary unilateral total knee arthroplasty (TKA). Patients (n = 133) treated with unilateral primary TKA were divided into three groups retrospectively: patients administered autologous blood transfusions were assigned to group A (n = 51); patients administered preoperative injections of TNA and postoperative intra-articular injections of DEP were assigned to group B (n = 42); and patients treated with the drain-clamp method in addition to injections of TNA and DEP were assigned to group C (n = 40). The rate of avoidance of ABTs, postoperative blood loss, and complications (DVT/PE, skin problems) were examined. The differences among the three groups were not significant in terms of the proportion of patients requiring no ABTs (94% in group A, 93% in group B and 95% in group C, n.s.). The total blood loss calculated was 1,140 +/- A 451 ml, 852 +/- A 343 ml, and 850 +/- A 296 ml, respectively (group B > A, group C > A, P = 0.0009). The significant complications were not observed in three groups. The results of the study showed that the TNA plus DEP combination exerted a comparable effect with preoperative autologous blood transfusion in avoiding ABTs in unilateral primary TKA. Considering several problems of preoperative autologous blood donation, the use of TNA plus DEP is recommended. In addition, it is highly possible that allogeneic blood transfusions can be avoided for patients with preoperative Hb values a parts per thousand yen10.5 using the method described in this study, and the need for preoperative autologous blood donations can be decreased.
  • Sasanuma H, Sekiya H, Takatoku K, Takada H, Sugimoto N
    Journal of orthopaedic surgery (Hong Kong) 18 26 - 30 1 2010年04月 [査読有り][通常論文]
  • Hitoshi Sekiya, Kenzo Takatoku, Hisashi Takada, Hideyuki Sasanuma, Naoya Sugimoto
    CLINICAL ORTHOPAEDICS AND RELATED RESEARCH 467 6 1582 - 1586 2009年06月 [査読有り][通常論文]
     
    For successful TKA, good soft tissue balance is one of the most important factors; however, it is unknown whether the coronal balance immediately after surgery is maintained with time. We hypothesized, if neutral mechanical alignment was achieved at the time of TKA, some degree of lateral ligamentous laxity could be accepted and the laxity would diminish with time. To confirm this hypothesis, we posed two scientific questions: (1) Does the coronal ligament balance measured immediately after TKA change with time? (2) Does the degree of preoperative varus alignment correlate with the lateral or medial ligamentous laxity observed after TKA? We measured coronal lateral or medial ligamentous laxity in 71 knees with varus deformities immediately after surgery and at 3, 6, and 12 months thereafter. The mean mechanical axis was 15.9A degrees varus preoperatively and 0.4A degrees varus postoperatively. The mean medial ligamentous laxity was relatively constant postoperatively from immediately after surgery to 12 months. However, the mean lateral ligamentous laxity was as much as 8.6A degrees immediately after surgery and decreased to 5.1A degrees at 3 months. The lateral ligamentous laxity immediately after surgery correlated with the preoperative varus mechanical axis. Our data show residual lateral ligamentous laxity observed in preoperative varus deformity may be corrected spontaneously after TKA.
  • Abe S, Kojima M, Kurihara H, Tamura H, Kitago M, Sasanuma H, Wada M, Ogihara T
    Gan to kagaku ryoho. Cancer & chemotherapy 29 1421 - 1426 8 2002年08月 [査読有り][通常論文]

MISC

共同研究・競争的資金等の研究課題

  • 文部科学省:科学研究費補助金(若手研究(B))
    研究期間 : 2010年 -2011年 
    代表者 : 笹沼 秀幸
     
    視床下部弓状核に存在するAgRPニューロンの骨代謝への影響を検討するために、ニューロン内転写因子として重要なPI3K系のPDK1に注目した。AgRPニューロン特異的PDK1ノックアウトマウスを作成し、その骨代謝解析を行った。同マウスは骨量減少を示した。そのシグナル経路としてAgRPニューロンがGHRH-GH-IGF1経路を介して骨代謝を制御することが示唆された。


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