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古川 雄祐 フルカワ ユウスケ

所属部署名幹細胞制御研究部
職名教授ホームページURLhttp://www.jichi.ac.jp/stem/index.html

プロフィール

プロフィール

    昭和57年 筑波大学・医学部 卒業 昭和62年 自治医科大学・血液科 病院助手 昭和63年 ハーバード大学・Dana-Farber癌研究所 研究員 平成04年 自治医科大学・血液医学研究部門 講師 平成11年 自治医科大学・分子病態治療研究センター 助教授 平成15年 自治医科大学・分子病態治療研究センター 教授 平成26年 自治医科大学・分子病態治療研究センター センター長

研究キーワード

    血液学, 分子生物学, 分子腫瘍学

研究分野

  • 生物科学 / 分子生物学
  • 生物科学 / 細胞生物学
  • 内科系臨床医学 / 血液内科学

経歴

  • 1988年01月
    -
    1988年09月
    自治医科大学・造血発生・助手
  • 1988年09月
    -
    1990年10月
    ハーバード大学・Dana-Farber癌研究所・所究員
  • 1992年10月
    -
    1999年09月
    自治医科大学・造血発生・講師
  • 1999年09月
    -
    2003年08月
    自治医科大学・幹細胞制御研究部門・助教授
  • 2003年08月
    -
    現在
    自治医科大学・幹細胞制御研究部門・教授
  • 2014年04月
    -
    現在
    自治医科大学・分子病態治療研究センター・センター長

学歴

  • 1976年04月
    -
    1982年03月
    筑波大学 医学専門学群(日本)

所属学協会

  • 日本骨髄腫学会
  • 日本血液学会
  • 日本内科学会
所属学協会を全て表示する
所属学協会閉じる
  • 日本骨髄腫学会
  • 日本血液学会
  • 日本内科学会

委員歴

  • 2017年
    -
    現在
    日本血液学会 プログラム委員
  • 2000年
    -
    2015年
    日本血液学会 評議員
  • 1993年
    日本臨床血液学会 評議員
審議会等委員を全て表示する
審議会等委員閉じる
  • 2017年
    -
    現在
    日本血液学会 プログラム委員
  • 2000年
    -
    2015年
    日本血液学会 評議員
  • 1993年
    日本臨床血液学会 評議員

学位

  • 医学博士

研究活動

論文

  • Lysine-specific demethylase 1 inhibitors prevent teratoma development from human induced pluripotent stem cells
    Osada N, Kikuchi J, Umehara T, Sato S, Urabe M, Abe T, Hayashi N, Sugitani M, Hanazono Y, Furukawa Y
    Oncotarget 9(5) 2018年01月
  • Myeloma Cells Are Activated in Bone Marrow Microenvironment by the CD180/MD-1 Complex, Which Senses Lipopolysaccharide
    Kikuchi J, Kuroda Y, Koyama D, Osada N, Izumi T, Yasui H, Kawase T, Ichinohe T, Furukawa Y
    Cancer Research 78(7) 1766 2018年01月
  • [Involvement of innate immunity in the expansion of multiple myeloma cells and therapeutic intervention with lenalidomide].
    Furukawa Y, Kuroda Y, Kikuchi J
    [Rinsho ketsueki] The Japanese journal of clinical hematology 2018年01月
  • Anti-leukemic activity of bortezomib and carfilzomib on B-cell precursor ALL cell lines.
    Takahashi K, Inukai T, Imamura T, Yano M, Tomoyasu C, Lucas DM, Nemoto A, Sato H, Huang M, Abe M, Kagami K, Shinohara T, Watanabe A, Somazu S, Sugita K
    PloS one 2017年12月
  • Cell adhesion-induced phosphorylation and inactivation of EZH2 confer drug resistance to acute myeloid leukemia cells.
    Kikuchi J, Kuroda Y, Koyama D, Furukawa Y
    International journal of hematology 2017年11月
  • Histone deacetylases as novel therapeutic targets for refractory and relapsed multiple myeloma
    Yusuke Furukawa
    Annals of Oncology 27(7) 2016年11月
  • Corrigendum to "Interferon-α repressed telomerase along with G1-accumulation of Daudi cells" [Cancer Letters 142 (1) (1999) 23-30].
    Akiyama M, Iwase S, Horiguchi-Yamada J, Saito S, Furukawa Y, Yamada O, Mizoguchi H, Ohno T, Yamada H
    Cancer letters 2016年07月
  • Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma.
    Furukawa Y, Kikuchi J
    International journal of hematology 2016年07月
  • Epigenetic regulation of cell adhesion-mediated drug resistance acquisition in multiple myeloma.
    Furukawa Y, Kikuchi J
    [Rinsho ketsueki] The Japanese journal of clinical hematology 2016年05月
  • Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia.
    Nemoto A, Saida S, Kato I, Kikuchi J, Furukawa Y, Maeda Y, Akahane K, Honna-Oshiro H, Goi K, Kagami K, Kimura S, Sato Y, Okabe S, Niwa A, Watanabe K, Inukai T
    Molecular cancer therapeutics 2015年12月
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論文等(論文)閉じる
  • Lysine-specific demethylase 1 inhibitors prevent teratoma development from human induced pluripotent stem cells
    Osada N, Kikuchi J, Umehara T, Sato S, Urabe M, Abe T, Hayashi N, Sugitani M, Hanazono Y, Furukawa Y
    Oncotarget 9(5) 2018年01月
  • Myeloma Cells Are Activated in Bone Marrow Microenvironment by the CD180/MD-1 Complex, Which Senses Lipopolysaccharide
    Kikuchi J, Kuroda Y, Koyama D, Osada N, Izumi T, Yasui H, Kawase T, Ichinohe T, Furukawa Y
    Cancer Research 78(7) 1766 2018年01月
  • [Involvement of innate immunity in the expansion of multiple myeloma cells and therapeutic intervention with lenalidomide].
    Furukawa Y, Kuroda Y, Kikuchi J
    [Rinsho ketsueki] The Japanese journal of clinical hematology 2018年01月
  • Anti-leukemic activity of bortezomib and carfilzomib on B-cell precursor ALL cell lines.
    Takahashi K, Inukai T, Imamura T, Yano M, Tomoyasu C, Lucas DM, Nemoto A, Sato H, Huang M, Abe M, Kagami K, Shinohara T, Watanabe A, Somazu S, Sugita K
    PloS one 2017年12月
  • Cell adhesion-induced phosphorylation and inactivation of EZH2 confer drug resistance to acute myeloid leukemia cells.
    Kikuchi J, Kuroda Y, Koyama D, Furukawa Y
    International journal of hematology 2017年11月
  • Histone deacetylases as novel therapeutic targets for refractory and relapsed multiple myeloma
    Yusuke Furukawa
    Annals of Oncology 27(7) 2016年11月
  • Corrigendum to "Interferon-α repressed telomerase along with G1-accumulation of Daudi cells" [Cancer Letters 142 (1) (1999) 23-30].
    Akiyama M, Iwase S, Horiguchi-Yamada J, Saito S, Furukawa Y, Yamada O, Mizoguchi H, Ohno T, Yamada H
    Cancer letters 2016年07月
  • Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma.
    Furukawa Y, Kikuchi J
    International journal of hematology 2016年07月
  • Epigenetic regulation of cell adhesion-mediated drug resistance acquisition in multiple myeloma.
    Furukawa Y, Kikuchi J
    [Rinsho ketsueki] The Japanese journal of clinical hematology 2016年05月
  • Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia.
    Nemoto A, Saida S, Kato I, Kikuchi J, Furukawa Y, Maeda Y, Akahane K, Honna-Oshiro H, Goi K, Kagami K, Kimura S, Sato Y, Okabe S, Niwa A, Watanabe K, Inukai T
    Molecular cancer therapeutics 2015年12月
  • Soluble αKlotho as a candidate for the biomarker of aging.
    Koyama D, Sato Y, Aizawa M, Maki T, Kurosawa M, Kuro-o M, Furukawa Y
    Biochemical and biophysical research communications 2015年10月
  • Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma.
    Kikuchi J, Koyama D, Wada T, Izumi T, Hofgaard PO, Bogen B, Furukawa Y
    The Journal of clinical investigation 125(12) 4375-4390 2015年10月
  • Overexpression of the Shortest Isoform of Histone Demethylase LSD1 Primes Hematopoietic Stem Cells for Malignant Transformation.
    Wada, T., Koyama, D., Kikuchi, J., Honda, H. and Furukawa, Y.
    Blood 125 3731-3746 2015年06月
  • Molecular Pathogenesis of Multiple Myeloma
    Furukawa Y and Kikuchi J
    Int. J. Clin. Oncol.(20) 413-422 2015年05月
  • Overexpression of the shortest isoform of histone demethylase LSD1 primes hematopoietic stem cells for malignant transformation.
    Wada T, Koyama D, Kikuchi J, Honda H, Furukawa Y
    Blood 2015年04月
  • Arf Tumor Suppressor Disrupts the Oncogenic Positive Feedback Loop Including c-Myc and DDX5.
    Tago, K., Funakoshi-Tago, M., Itoh, H., Furukawa, Y., Kikuchi, J., Kato, T., Suzuki, K. and Yanagisawa, K.
    Oncogene 34 310-318 2015年02月
  • [The mechanisms of drug resistance via the interaction of myeloma cells with stromal cells].
    Kikuchi J, Furukawa Y
    Nihon rinsho. Japanese journal of clinical medicine 73 57-61 2015年01月
  • Suitable drug combination with bortezomib for multiple myeloma under stroma-free conditions and in contact with fibronectin or bone marrow stromal cells.
    Kikuchi J, Koyama D, Mukai HY, Furukawa Y
    International journal of hematology 99 726-736 2014年06月
  • [DNA methyltransferase inhibitors * histone deacetylase inhibitors].
    Kikuchi J, Furukawa Y
    Nihon rinsho. Japanese journal of clinical medicine 72 1136-1142 2014年06月
  • Purine analog-like properties of bendamustine underlie rapid activation of DNA damage response and synergistic effects with pyrimidine analogues in lymphoid malignancies.
    Hiraoka N, Kikuchi J, Yamauchi T, Koyama D, Wada T, Uesawa M, Akutsu M, Mori S, Nakamura Y, Ueda T, Kano Y, Furukawa Y
    PLoS One 9 e90675 2014年03月
  • Proteasome Inhibitors Exert Cytotoxicity and Increase Chemosensitivity via Transcriptional Repression of Notch1 in T-cell Acute Lymphoblastic Leukemia.
    Koyama, D., Kikuchi, J., Hiraoka, N., Wada, T., Kurosawa, H., Chiba, S. and Furukawa, Y.
    Leukemia 28 1216-1226 2014年01月
  • Romidepsin overcomes cell adhesion-mediated drug resistance in multiple myeloma cells.
    Sripayap P, Nagai T, Hatano K, Kikuchi J, Furukawa Y, Ozawa K
    Acta haematologica 132 1-4 2014年
  • Alkylating agents induce histone H3K18 hyperacetylation and potentiate HDAC inhibitor-mediated global histone acetylation and cytotoxicity in mantle cell lymphoma.
    Hiraoka N, Kikuchi J, Koyama D, Wada T, Mori S, Nakamura Y, Furukawa Y
    Blood cancer journal 2013年12月
  • [Molecular oncogenesis of multiple myeloma].
    Furukawa Y
    [Rinsho ketsueki] The Japanese journal of clinical hematology 54 1867-1875 2013年10月
  • The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases.
    Kikuchi J, Yamada S, Koyama D, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Furukawa Y
    The Journal of biological chemistry 288 25593-25602 2013年08月
  • [How to overcome the cell adhesion-mediated drug resistance in multiple myeloma].
    Furukawa Y, Kikuchi J
    [Rinsho ketsueki] The Japanese journal of clinical hematology 54 513-521 2013年06月
  • Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding.
    Kikuchi J, Shibayama N, Yamada S, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Sugiyama K, Ohki M, Park SY, Furukawa Y
    PloS one 8 e60649 2013年04月
  • Promoter methylation confers kidney-specific expression of the Klotho gene.
    Azuma M, Koyama D, Kikuchi J, Yoshizawa H, Thasinas D, Shiizaki K, Kuro-o M, Furukawa Y, Kusano E
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26 4264-4274 2012年10月
  • Reduced histone H3K9 acetylation of clock genes and abnormal glucose metabolism in ob/ob mice.
    Ishikawa-Kobayashi E, Ushijima K, Ando H, Maekawa T, Takuma M, Furukawa Y, Fujimura A
    Chronobiology international 29 982-993 2012年10月
  • BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia.
    Kuroda I, Inukai T, Zhang X, Kikuchi J, Furukawa Y, Nemoto A, Akahane K, Hirose K, Honna-Oshiro H, Goi K, Kagami K, Yagita H, Tauchi T, Maeda Y, Sugita K
    Oncogene 2012年06月
  • Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells.
    Mitsunaga K, Kikuchi J, Wada T, Furukawa Y
    Journal of cellular physiology 227 1138-1147 2012年03月
  • Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8.
    Wada T, Kikuchi J, Furukawa Y
    EMBO reports 13 142-149 2012年02月
  • [Mechanisms of action and clinical effectiveness of the newly approved anti-cancer drug bendamustine].
    Furukawa Y, Hiraoka N, Wada T, Kikuchi J, Kano Y
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica 138 26-32 2011年07月
  • Seven-year follow-up of patients receiving imatinib for the treatment of newly diagnosed chronic myelogenous leukemia by the TARGET system.
    Tauchi T, Kizaki M, Okamoto S, Tanaka H, Tanimoto M, Inokuchi K, Murayama T, Saburi Y, Hino M, Tsudo M, Shimomura T, Isobe Y, Oshimi K, Dan K, TARGET Investigators
    Leukemia research 2010年12月
  • Vinculin is indispensable for repopulation by hematopoietic stem cells, independent of integrin function.
    Ohmori T, Kashiwakura Y, Ishiwata A, Madoiwa S, Mimuro J, Furukawa Y, Sakata Y
    The Journal of biological chemistry 285 31763-31773 2010年10月
  • Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
    Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, G?ttgens B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Honna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T, Sugita K
    Blood 116 962-970 2010年08月
  • HDAC inhibitors augment cytotoxic activity of rituximab by upregulating CD20 expression on lymphoma cells.
    Shimizu R, Kikuchi J, Wada T, Ozawa K, Kano Y, Furukawa Y
    Leukemia 2010年08月
  • Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma.
    Kikuchi J, Wada T, Shimizu R, Izumi T, Akutsu M, Mitsunaga K, Noborio-Hatano K, Nobuyoshi M, Ozawa K, Kano Y, Furukawa Y
    Blood 116 406-417 2010年07月
  • MSK1 activation in acute myeloid leukemia cells with FLT3 mutations.
    Odgerel T, Kikuchi J, Wada T, Shimizu R, Kano Y, Furukawa Y
    Leukemia 2010年04月
  • Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.
    Okuya M, Kurosawa H, Kikuchi J, Furukawa Y, Matsui H, Aki D, Matsunaga T, Inukai T, Goto H, Altura RA, Sugita K, Arisaka O, Look AT, Inaba T
    The Journal of biological chemistry 285 1850-1860 2010年01月
  • Schedule-dependent synergism and antagonism between pemetrexed and docetaxel in human lung cancer cell lines in vitro.
    Kano Y, Tanaka M, Akutsu M, Mori K, Yazawa Y, Mano H, Furukawa Y
    Cancer chemotherapy and pharmacology 64 1129-1137 2009年11月
  • The cytotoxic effects of gemtuzumab ozogamicin (mylotarg) in combination with conventional antileukemic agents by isobologram analysis in vitro.
    Tanaka M, Kano Y, Akutsu M, Tsunoda S, Izumi T, Yazawa Y, Miyawaki S, Mano H, Furukawa Y
    Anticancer research 29 4589-4596 2009年11月
  • Expression levels of histone deacetylases determine the cell fate of hematopoietic progenitors.
    Wada T, Kikuchi J, Nishimura N, Shimizu R, Kitamura T, Furukawa Y
    The Journal of biological chemistry 284 30673-30683 2009年10月
  • A novel missense mutation of ABCA1 in transmembrane alpha-helix in a Japanese patient with Tangier disease.
    Maekawa M, Kikuchi J, Kotani K, Nagao K, Odgerel T, Ueda K, Kawano M, Furukawa Y, Sakurabayashi I
    Atherosclerosis 206 216-222 2009年09月
  • Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
    Sekiya M, Osuga J, Nagashima S, Ohshiro T, Igarashi M, Okazaki H, Takahashi M, Tazoe F, Wada T, Ohta K, Takanashi M, Kumagai M, Nishi M, Takase S, Yahagi N, Yagyu H, Ohashi K, Nagai R, Kadowaki T, Furukawa Y, Ishibashi S
    Cell metabolism 10 219-228 2009年09月
  • Vasoactive intestinal peptide and inflammatory cytokines enhance vascular endothelial growth factor production from epidermal keratinocytes.
    Kakurai M, Demitsu T, Umemoto N, Kobayashi Y, Inoue-Narita T, Fujita N, Ohtsuki M, Furukawa Y
    The British journal of dermatology 2009年08月
  • Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
    Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Ogawa S
    Nature 2009年07月
  • Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells.
    Kobayashi T, Furukawa Y, Kikuchi J, Ito C, Miyata Y, Muto S, Tanaka A, Kusano E
    Kidney international 75 1173-1183 2009年06月
  • Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma.
    Noborio-Hatano K, Kikuchi J, Takatoku M, Shimizu R, Wada T, Ueda M, Nobuyoshi M, Oh I, Sato K, Suzuki T, Ozaki K, Mori M, Nagai T, Muroi K, Kano Y, Ozawa K
    Oncogene 2008年10月
  • [Epigenetics in hematological disorders].
    Furukawa Y
    [Rinsho ketsueki] The Japanese journal of clinical hematology 49 1472-1482 2008年10月
  • Ras-mediated up-regulation of survivin expression in cytokine-dependent murine pro-B lymphocytic cells.
    Shinjyo T, Kurosawa H, Miyagi J, Ohama K, Masuda M, Nagasaki A, Matsui H, Inaba T, Furukawa Y, Takasu N
    The Tohoku journal of experimental medicine 216 25-34 2008年09月
  • Transcriptional modulation using HDACi depsipeptide promotes immune cell-mediated tumor destruction of murine B16 melanoma.
    Murakami T, Sato A, Chun NA, Hara M, Naito Y, Kobayashi Y, Kano Y, Ohtsuki M, Furukawa Y, Kobayashi E
    The Journal of investigative dermatology 128 1506-1516 2008年06月
  • Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes.
    Ishii H, Mimori K, Ishikawa K, Okumura H, Pichiorri F, Druck T, Inoue H, Vecchione A, Saito T, Mori M, Huebner K
    Cancer research 2008年05月
  • Cholesterol reduction and atherosclerosis inhibition by bezafibrate in low-density lipoprotein receptor knockout mice.
    Inaba T, Yagyu H, Itabashi N, Tazoe F, Fujita N, Nagashima S, Okada K, Okazaki M, Furukawa Y, Ishibashi S
    Hypertension research : official journal of the Japanese Society of Hypertension 31 999-1005 2008年05月
  • CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1.
    Nonomura C, Kikuchi J, Kiyokawa N, Ozaki H, Mitsunaga K, Ando H, Kanamori A, Kannagi R, Fujimoto J, Muroi K, Furukawa Y, Nakamura M
    Cancer research 68 790-799 2008年02月
  • Long-term results of dose-intensive chemotherapy with G-CSF support (TCC-NHL-91) for advanced intermediate-grade non-Hodgkin's lymphoma: a review of 59 consecutive cases treated at a single institute.
    Akutsu M, Tsunoda S, Izumi T, Tanaka M, Katano S, Inoue K, Igarashi S, Hirabayashi K, Furukawa Y, Ohmine K, Sato K, Kobayashi H, Ozawa K, Kirito K, Nagashima T, Teramukai S, Fukushima M, Kano Y
    Oncology research 17 137-149 2008年01月
  • Activation of focal adhesion kinase in detached human epidermal cancer cells and their long-term survival might be associated with cell surface expression of laminin-5.
    Katayama H, Yamane Y, Furukawa Y, Kitagawa S, Nakamura Y, Yoshino K
    Acta dermato-venereologica 88 100-107 2008年
  • The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations.
    Odgerel T, Kikuchi J, Wada T, Shimizu R, Futaki K, Kano Y, Furukawa Y
    Oncogene 2007年12月
  • E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1.
    Kikuchi J, Shimizu R, Wada T, Ando H, Nakamura M, Ozawa K, Furukawa Y
    Stem cells (Dayton, Ohio) 25 2439-2447 2007年10月
  • Rad9 modulates the P21WAF1 pathway by direct association with p53.
    Ishikawa K, Ishii H, Murakumo Y, Mimori K, Kobayashi M, Yamamoto K, Mori M, Nishino H, Furukawa Y, Ichimura K
    BMC molecular biology 8 37 2007年05月
  • Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
    Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Croce CM
    Cancer cell 2007年03月
  • Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines.
    Furukawa Y, Vu HA, Akutsu M, Odgerel T, Izumi T, Tsunoda S, Matsuo Y, Kirito K, Sato Y, Mano H, Kano Y
    Leukemia 2007年03月
  • Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines.
    Kano Y, Akutsu M, Tsunoda S, Izumi T, Kobayashi H, Mano H, Furukawa Y
    Investigational new drugs 25 31-40 2007年02月
  • Fhit modulates the DNA damage checkpoint response.
    Ishii H, Mimori K, Inoue H, Inageta T, Ishikawa K, Semba S, Druck T, Trapasso F, Tani K, Vecchione A, Croce CM, Mori M, Huebner K
    Cancer research 2006年12月
  • Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib.
    Sutheesophon K, Kobayashi Y, Takatoku MA, Ozawa K, Kano Y, Ishii H, Furukawa Y
    Acta haematologica 115 78-90 2006年01月
  • Schedule-dependent interactions between pemetrexed and cisplatin in human carcinoma cell lines in vitro.
    Kano Y, Akutsu M, Tsunoda S, Izumi T, Kobayashi H, Inoue K, Mori K, Fujii H, Mano H, Odgerel T, Furukawa Y
    Oncology research 16 85-95 2006年01月
  • Histone deacetylase inhibitor FK228 suppresses the Ras-MAP kinase signaling pathway by upregulating Rap1 and induces apoptosis in malignant melanoma.
    Kobayashi Y, Ohtsuki M, Murakami T, Kobayashi T, Sutheesophon K, Kitayama H, Kano Y, Kusano E, Nakagawa H, Furukawa Y
    Oncogene 2006年01月
  • Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis.
    Ishii H, Inageta T, Mimori K, Saito T, Sasaki H, Isobe M, Mori M, Croce CM, Huebner K, Ozawa K, Furukawa Y
    Proceedings of the National Academy of Sciences of the United States of America 102 9655-9660 2005年07月
  • Methylation silencing of the Apaf-1 gene in acute leukemia.
    Furukawa Y, Sutheesophon K, Wada T, Nishimura M, Saito Y, Ishii H, Furukawa Y
    Molecular cancer research : MCR 3 325-334 2005年06月
  • Involvement of the tumor necrosis factor (TNF)/TNF receptor system in leukemic cell apoptosis induced by histone deacetylase inhibitor depsipeptide (FK228).
    Sutheesophon K, Nishimura N, Kobayashi Y, Furukawa Y, Kawano M, Itoh K, Kano Y, Ishii H, Furukawa Y
    Journal of cellular physiology 203 387-397 2005年05月
  • Differential roles of E-type cyclins during transformation of murine E2F-1-deficient cells.
    Ishii H, Mimori K, Yoshikawa Y, Mori M, Furukawa Y, Vecchione A
    DNA and cell biology 24 173-179 2005年03月
  • Components of DNA damage checkpoint pathway regulate UV exposure-dependent alterations of gene expression of FHIT and WWOX at chromosome fragile sites.
    Ishii H, Mimori K, Inageta T, Murakumo Y, Vecchione A, Mori M, Furukawa Y
    Molecular cancer research : MCR 3 130-138 2005年03月
  • Schedule-dependent synergism and antagonism between pemetrexed and paclitaxel in human carcinoma cell lines in vitro.
    Kano Y, Akutsu M, Tsunoda S, Izumi T, Mori K, Fujii H, Yazawa Y, Mano H, Furukawa Y
    Cancer chemotherapy and pharmacology 54 505-513 2004年12月
  • Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats.
    Ishii H, Vecchione A, Furukawa Y, Croce CM, Huebner K, Fong LY
    Oncogene 23 8040-8048 2004年10月
  • Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect.
    Kawano T, Horiguchi-Yamada J, Iwase S, Akiyama M, Furukawa Y, Kan Y, Yamada H
    Anticancer research 24 2705-2712 2004年09月
  • Role of cyclins in cAMP inhibition of glomerular mesangial cell proliferation.
    Ito C, Yamamoto H, Furukawa Y, Takeda S, Akimoto T, Iimura O, Ando Y, Asano Y, Kusano E
    Clinical science (London, England : 1979) 107 81-87 2004年07月
  • Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation of K562 cells.
    Kawano T, Horiguchi-Yamada J, Saito S, Iwase S, Furukawa Y, Kano Y, Yamada H
    Leukemia research 28 623-629 2004年06月
  • Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX.
    Ishii H, Mimori K, Vecchione A, Sutheesophon K, Fujiwara T, Mori M, Furukawa Y
    Biochemical and biophysical research communications 316 1088-1093 2004年04月
  • Alterations of common chromosome fragile sites in hematopoietic malignancies.
    Ishii H, Furukawa Y
    International journal of hematology 79 238-242 2004年04月
  • Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it.
    Kawano T, Horiguchi-Yamada J, Iwase S, Furukawa Y, Kano Y, Yamada H
    Molecular and cellular biochemistry 258 25-33 2004年03月
  • Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses.
    Ishii H, Vecchione A, Fong LY, Zanesi N, Trapasso F, Furukawa Y, Baffa R, Huebner K, Croce CM
    Current gene therapy 4 53-63 2004年03月
  • Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.
    Ishii H, Vecchione A, Furukawa Y, Sutheesophon K, Han SY, Druck T, Kuroki T, Trapasso F, Nishimura M, Saito Y, Ozawa K, Croce CM, Huebner K, Furukawa Y
    Molecular cancer research : MCR 1 940-947 2003年11月
  • Alteration of the fragile histidine triad gene early in carcinogenesis: an update.
    Ishii H, Ozawa K, Furukawa Y
    Journal of experimental therapeutics & oncology 3 291-296 2003年11月
  • Suppression of ARG kinase activity by STI571 induces cell cycle arrest through up-regulation of CDK inhibitor p18/INK4c.
    Nishimura N, Furukawa Y, Sutheesophon K, Nakamura M, Kishi K, Okuda K, Sato Y, Kano Y
    Oncogene 22 4074-4082 2003年06月
  • A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression.
    Inaba N, Hiruma T, Togayachi A, Iwasaki H, Wang XH, Furukawa Y, Sumi R, Kudo T, Fujimura K, Iwai T, Gotoh M, Nakamura M, Narimatsu H
    Blood 101 2870-2876 2003年04月
  • Identification of novel p53-binding proteins by biomolecular interaction analysis combined with tandem mass spectrometry.
    Kikuchi J, Furukawa Y, Hayashi N
    Molecular biotechnology 23 203-212 2003年03月
  • Modulation of the erythropoietin-induced proliferative pathway by cAMP in vascular smooth muscle cells.
    Ito C, Kusano E, Furukawa Y, Yamamoto H, Takeda S, Akimoto T, Iimura O, Ando Y, Asano Y
    American journal of physiology. Cell physiology 283 C1715-21 2002年12月
  • Vasoactive intestinal peptide and cytokines enhance stem cell factor production from epidermal keratinocytes DJM-1.
    Kakurai M, Fujita N, Kiyosawa T, Inoue T, Ishibashi S, Furukawa Y, Demitsu T, Nakagawa H
    The Journal of investigative dermatology 119 1183-1188 2002年11月
  • Apaf-1 is a mediator of E2F-1-induced apoptosis.
    Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M
    The Journal of biological chemistry 277 39760-39768 2002年10月
  • Schedule-dependent synergism and antagonism between methotrexate and cytarabine against human leukemia cell lines in vitro.
    Akutsu M, Furukawa Y, Tsunoda S, Izumi T, Ohmine K, Kano Y
    Leukemia 2002年09月
  • Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells.
    Fujita N, Furukawa Y, Itabashi N, Okada K, Saito T, Ishibashi S
    American journal of physiology. Heart and circulatory physiology 283 H204-12 2002年07月
  • Hyperglycemia enhances VSMC proliferation with NF-kappaB activation by angiotensin II and E2F-1 augmentation by growth factors.
    Fujita N, Furukawa Y, Du J, Itabashi N, Fujisawa G, Okada K, Saito T, Ishibashi S
    Molecular and cellular endocrinology 192 75-84 2002年06月
  • [Effectiveness of prolonged oral administration of low-dose etoposide in a case of malignant lymphoma in the mesenterium].
    Sato T, Yanagihara M, Sato K, Nozawa T, Furukawa Y, Imanishi H, Kouzuma T
    Gan to kagaku ryoho. Cancer & chemotherapy 29 959-962 2002年06月
  • Phosphorylation of Fanconi anemia protein, FANCA, is regulated by Akt kinase.
    Otsuki T, Nagashima T, Komatsu N, Kirito K, Furukawa Y, Kobayashi Si S, Liu JM, Ozawa K
    Biochemical and biophysical research communications 291 628-634 2002年03月
  • Cell cycle control genes and hematopoietic cell differentiation.
    Furukawa Y
    Leukemia & lymphoma 43 225-231 2002年02月
  • Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex.
    Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM
    Human molecular genetics 2001年11月
  • Antitumor effect of beta2-microglobulin in leukemic cell-bearing mice via apoptosis-inducing activity: activation of caspase-3 and nuclear factor-kappaB.
    Mori M, Terui Y, Tanaka M, Tomizuka H, Mishima Y, Ikeda M, Kasahara T, Uwai M, Ueda M, Inoue R, Itoh T, Yamada M, Hayasawa H, Furukawa Y, Ishizaka Y, Hatake K
    Cancer research 2001年06月
  • Vasoactive intestinal peptide regulates its receptor expression and functions of human keratinocytes via type I vasoactive intestinal peptide receptors.
    Kakurai M, Fujita N, Murata S, Furukawa Y, Demitsu T, Nakagawa H
    The Journal of investigative dermatology 2001年05月
  • In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents.
    Kano Y, Akutsu M, Tsunoda S, Mano H, Sato Y, Honma Y, Furukawa Y
    Blood 2001年04月
  • Stimulation of GATA-2 as a mechanism of hydrogen peroxide suppression in hypoxia-induced erythropoietin gene expression.
    Tabata M, Tarumoto T, Ohmine K, Furukawa Y, Hatake K, Ozawa K, Hasegawa Y, Mukai H, Yamamoto M, Imagawa S
    Journal of cellular physiology 2001年02月
  • Schedule-dependent synergism and antagonism between raltitrexed ("Tomudex") and methotrexate in human colon cancer cell lines in vitro.
    Kano Y, Akutsu M, Tsunoda S, Suzuki K, Yazawa Y, Furukawa Y
    Japanese journal of cancer research : Gann 2001年01月
  • Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells.
    Kawasaki A, Matsumura I, Miyagawa Ji, Ezoe S, Tanaka H, Terada Y, Tatsuka M, Machii T, Miyazaki H, Furukawa Y, Kanakura Y
    The Journal of cell biology 2001年01月
  • Lineage-specific regulation of cell cycle control gene expression during haematopoietic cell differentiation.
    Furukawa Y, Kikuchi J, Nakamura M, Iwase S, Yamada H, Matsuda M
    British journal of haematology 2000年09月
  • Phosphorylation of Bcl-2 protein by CDC2 kinase during G2/M phases and its role in cell cycle regulation.
    Furukawa Y, Iwase S, Kikuchi J, Terui Y, Nakamura M, Yamada H, Kano Y, Matsuda M
    The Journal of biological chemistry 2000年07月
  • A simple semisolid subtraction method using carbodiimide-coated microplates.
    Kikuchi J, Furukawa Y, Suzuki O, Hayashi N, Nakamura M, Morita M, Matsuda M
    Molecular biotechnology 2000年07月
  • Three-dimensional matrix suppresses E2F-controlled gene expression in glomerular mesangial cells.
    Tsuboi N, Yoshida H, Kawamura T, Furukawa Y, Hosoya T, Yamada H
    Kidney international 2000年04月
  • In vitro cytotoxic effects of fludarabine (2-F-ara-A) in combination with commonly used antileukemic agents by isobologram analysis.
    Kano Y, Akutsu M, Tsunoda S, Suzuki K, Ichikawa A, Furukawa Y, Bai L, Kon K
    Leukemia 2000年03月
  • Schedule-dependent interaction between raltitrexed and 5-fluorouracil in human colon cancer cell lines in vitro.
    Kano Y, Akutsu M, Suzuki K, Yazawa Y, Tsunoda S, Furukawa Y
    Oncology research 2000年01月
  • Regulation of macrophage-specific gene expression by degenerated lipoproteins.
    Furukawa Y, Kubo N, Kikuchi J, Tokura A, Fujita N, Sakurabayashi I
    Electrophoresis 2000年01月
  • Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis.
    Kikuchi J, Furukawa Y, Kubo N, Tokura A, Hayashi N, Nakamura M, Matsuda M, Sakurabayashi I
    Arteriosclerosis, thrombosis, and vascular biology 2000年01月
  • Simultaneous core 2 beta1-->6N-acetylglucosaminyltransferase up-regulation and sialyl-Le(X) expression during activation of human tonsillar B lymphocytes.
    Nakamura M, Ishida T, Kikuchi J, Furukawa Y, Matsuda M
    FEBS letters 1999年12月
  • Beta(2)-microglobulin identified as an apoptosis-inducing factor and its characterization.
    Mori M, Terui Y, Ikeda M, Tomizuka H, Uwai M, Kasahara T, Kubota N, Itoh T, Mishima Y, Douzono-Tanaka M, Yamada M, Shimamura S, Kikuchi J, Hatake K
    Blood 1999年10月
  • Failure of cdc2 promoter activation and G(2)/M transition by ANG II and AVP in vascular smooth muscle cells.
    Fujita N, Furukawa Y, Itabashi N, Tsuboi Y, Matsuda M, Okada K, Saito T
    The American journal of physiology 1999年08月
  • Interferon-alpha repressed telomerase along with G1-accumulation of Daudi cells.
    Akiyama M, Iwase S, Horiguchi-Yamada J, Saito S, Furukawa Y, Yamada O, Mizoguchi H, Ohno T, Yamada H
    Cancer letters 1999年07月
  • Defective binding of IRFs to the initiator element of interleukin-1beta-converting enzyme (ICE) promoter in an interferon-resistant Daudi subline.
    Iwase S, Furukawa Y, Kikuchi J, Saito S, Nakamura M, Nakayama R, Horiguchi-Yamada J, Yamada H
    FEBS letters 1999年05月
  • Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes.
    Furukawa Y, Iwase S, Kikuchi J, Nakamura M, Yamada H, Matsuda M
    Oncogene 1999年03月
  • UDP-GlcNAc:Galbeta1-->3GalNAc (GlcNAc to GalNAc) beta1-->6N-acetylglucosaminyltransferase holds a key role on the control of CD15s expression in human pre-B lymphoid cell lines.
    Nakamura M, Furukawa Y, Sasaki R, Masuyama J, Kikuchi J, Iwase S, Kudo T, Narimatsu H, Asakura S, Fujiwara S, Inokuchi J
    Glycobiology 1999年01月
  • Single glycosyltransferase, core 2 beta1-->6-N-acetylglucosaminyltransferase, regulates cell surface sialyl-Lex expression level in human pre-B lymphocytic leukemia cell line KM3 treated with phorbolester.
    Nakamura M, Kudo T, Narimatsu H, Furukawa Y, Kikuchi J, Asakura S, Yang W, Iwase S, Hatake K, Miura Y
    The Journal of biological chemistry 1998年10月
  • A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons.
    Sakamoto H, Yasukawa H, Masuhara M, Tanimura S, Sasaki A, Yuge K, Ohtsubo M, Ohtsuka A, Fujita T, Ohta T, Furukawa Y, Iwase S, Yamada H, Yoshimura A
    Blood 1998年09月
  • Cell cycle regulation of hematopoietic stem cells.
    Furukawa Y
    Human cell 1998年06月
  • A novel variant of acute myelomonocytic leukemia carrying t(3;12)(q26;p13) with characteristics of 3q21q26 syndrome.
    Iwase S, Furukawa Y, Horiguchi-Yamada J, Nemoto T, Takahara S, Kawano T, Sekikawa T, Ito K, Yamazaki Y, Kikuchi J, Morishita K, Yamada H
    International journal of hematology 1998年06月
  • [Retrospective analysis of elderly patients > or = 60 years of age with acute leukemia].
    Tabata M, Yoshida M, Izumi T, Kawano C, Kuribara R, Toshima M, Omine K, Takatoku M, Uchida M, Kirito K, Miyazato A, Takahashi H, Hoshino M, Terui Y, Miura Y
    [Rinsho ketsueki] The Japanese journal of clinical hematology 1998年03月
  • Bcl-x is a regulatory factor of apoptosis and differentiation in megakaryocytic lineage cells.
    Terui Y, Furukawa Y, Kikuchi J, Iwase S, Hatake K, Miura Y
    Experimental hematology 1998年03月
  • Human monocyte-endothelial cell interaction induces platelet-derived growth factor expression.
    Funayama H, Ikeda U, Takahashi M, Sakata Y, Kitagawa S, Takahashi Y, Masuyama J, Furukawa Y, Miura Y, Kano S, Matsuda M, Shimada K
    Cardiovascular research 1998年01月
  • Cell cycle control during hematopoietic cell differentiation.
    Furukawa Y
    Human cell 1997年09月
  • CMP-NeuAc:Gal beta 1-->4GlcNAc alpha 2-->6sialyltransferase catalyzes NeuAc transfer to glycolipids.
    Nakamura M, Tsunoda A, Yanagisawa K, Furukawa Y, Kikuchi J, Iwase S, Sakai T, Larson G, Saito M
    Journal of lipid research 1997年09月
  • Regulatory effects of aggregated LDL on apoptosis during foam cell formation of human peripheral blood monocytes.
    Kubo N, Kikuchi J, Furukawa Y, Sakai T, Ohta H, Iwase S, Yamada H, Sakurabayashi I
    FEBS letters 1997年06月
  • Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization.
    Kikuchi J, Furukawa Y, Iwase S, Terui Y, Nakamura M, Kitagawa S, Kitagawa M, Komatsu N, Miura Y
    Blood 1997年06月
  • Modulation of E2F activity is linked to interferon-induced growth suppression of hematopoietic cells.
    Iwase S, Furukawa Y, Kikuchi J, Nagai M, Terui Y, Nakamura M, Yamada H
    The Journal of biological chemistry 1997年05月
  • Chloroquine induces basophilic differentiation of HL-60 cells.
    Sasaki R, Furukawa Y, Okada K, Nakamura M, Yamane Y, Miura Y, Eguchi M
    Leukemia 1997年04月
  • Antileukemic effect of interferon-alpha is mediated through down-modulation of E2F activity.
    Furukawa Y, Iwase S
    Leukemia 1997年04月
  • Cell-cycle-dependent regulation of erythropoietin receptor gene.
    Komatsu N, Kirito K, Kashii Y, Furukawa Y, Kikuchi J, Suwabe N, Yamamoto M, Miura Y
    Blood 1997年02月
  • The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells.
    Yanagisawa K, Naito Y, Kuroiwa K, Arai T, Furukawa Y, Tomizuka H, Miura Y, Kasahara T, Tetsuka T, Tominaga S
    Journal of biochemistry 1997年01月
  • Rapid internalization of exogenous ganglioside GM3 and its metabolism to ceramide in human myelogenous leukemia HL-60 cells compared with control ganglioside GM1.
    Nakamura M, Tsunoda A, Furukawa Y, Sakai T, Saito M
    FEBS letters 1997年01月
  • Herbimycin A down-regulates messages of cyclin D1 and c-myc during erythroid differentiation of K562 cells.
    Yamada H, Iwase S, Nagai M, Nemoto T, Sekikawa T, Takahara S, Nakada S, Furukawa Y, Horiguchi-Yamada J
    International journal of hematology 1996年12月
  • Transcriptional activation of the cdc2 gene is associated with Fas-induced apoptosis of human hematopoietic cells.
    Furukawa Y, Iwase S, Terui Y, Kikuchi J, Sakai T, Nakamura M, Kitagawa S, Kitagawa M
    The Journal of biological chemistry 1996年11月
  • Tenascin-X expression in tumor cells and fibroblasts: glucocorticoids as negative regulators in fibroblasts.
    Sakai T, Furukawa Y, Chiquet-Ehrismann R, Nakamura M, Kitagawa S, Ikemura T, Matsumoto K
    Journal of cell science 1996年08月
  • Interleukin-3-associated ganglioside GD1a is induced independently of normal interleukin-3 receptor in murine myelogenous leukaemia NFS60 cells transfected with the interleukin-3 gene.
    Nakamura M, Kirito K, Tsunoda A, Hara K, Furukawa Y, Saito M
    Glycoconjugate journal 1996年04月
  • Up-regulation of VLA-5 expression during monocytic differentiation and its role in negative control of the survival of peripheral blood monocytes.
    Terui Y, Furukawa Y, Sakai T, Kikuchi J, Sugahara H, Kanakura Y, Kitagawa S, Miura Y
    Journal of immunology (Baltimore, Md. : 1950) 1996年03月
  • Human monocyte-endothelial cell interaction induces synthesis of granulocyte-macrophage colony-stimulating factor.
    Takahashi M, Kitagawa S, Masuyama JI, Ikeda U, Kasahara T, Takahashi YI, Furukawa Y, Kano S, Shimada K
    Circulation 1996年03月
  • Activation of human monocyte functions by tumor necrosis factor: rapid priming for enhanced release of superoxide and erythrophagocytosis, but no direct triggering of superoxide release.
    Kitagawa S, Yuo A, Yagisawa M, Azuma E, Yoshida M, Furukawa Y, Takahashi M, Masuyama J, Takaku F
    Experimental hematology 1996年03月
  • [Retrospective analysis on 21 patients with follicular lymphoma]
    Izumi T, Imagawa S, Muroi K, Shimizu R, Takahashi H, Hoshino Y, Tomizuka H, Kawakami T, Toya K, Kurata H, Tsunoda J, Furukawa Y, Suzuki T, Komatsu N, Miura Y
    [Rinsho ketsueki] The Japanese journal of clinical hematology 1996年01月
  • Combination chemotherapy of carboplatin and cytosine arabinoside for high-risk leukemia: a pilot study.
    Iwao N, Yoshida M, Hatake K, Hoshino Y, Hagiwara S, Tomizuka H, Shimizu R, Suzuki T, Furukawa Y, Komatsu N
    Leukemia research 1995年12月
  • Biosynthesis of the so-called "a" and "asialo" pathway glycosphingolipids is differentially regulated in murine myelogenous leukemia NFS60 cells.
    Nakamura M, Sakai T, Furukawa Y, Kitagawa S, Sakoe K, Tsunoda A
    Biochemical and biophysical research communications 1995年12月
  • Regulation of EGF-induced tenascin-C by steroids in tenascin-C-non-producing human carcinoma cells.
    Sakai T, Kawakatsu H, Furukawa Y, Saito M
    International journal of cancer 1995年11月
  • Tenascin-C induction by the diffusible factor epidermal growth factor in stromal-epithelial interactions.
    Sakai T, Ohta M, Furukawa Y, Saga Y, Aizawa S, Kawakatsu H, Saito M
    Journal of cellular physiology 1995年10月
  • Apoptosis during HL-60 cell differentiation is closely related to a G0/G1 cell cycle arrest.
    Terui Y, Furukawa Y, Kikuchi J, Saito M
    Journal of cellular physiology 1995年07月
  • Over-expression and amplification of the CDC2 gene in leukaemia cells.
    Furukawa Y, Terui Y, Sakoe K, Ohta M, Kitagawa S, Miura Y, Saito M
    British journal of haematology 1995年05月
  • Tenascin-C induction in Whitlock-Witte culture: a relevant role of the thiol moiety in lymphoid-lineage differentiation.
    Sakai T, Ohta M, Kawakatsu H, Furukawa Y, Saito M
    Experimental cell research 1995年04月
  • Preferential production of interleukin-1 beta over interleukin-1 receptor antagonist contributes to proliferation and suppression of apoptosis in leukemic cells.
    Furukawa Y, Kikuchi J, Terui Y, Kitagawa S, Ohta M, Miura Y, Saito M
    Japanese journal of cancer research : Gann 1995年02月
  • Expression of differentiation-related phenotypes and apoptosis are independently regulated during myeloid cell differentiation.
    Terui Y, Furukawa Y, Sakoe K, Ohta M, Saito M
    Journal of biochemistry 1995年01月
  • The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells.
    Furukawa Y, Terui Y, Sakoe K, Ohta M, Saito M
    The Journal of biological chemistry 1994年10月
  • [Treatment of 71 adult acute lymphoblastic leukemia]
    Yoshida M, Kurata H, Tsunoda S, Iwama A, Suzuki T, Akutsu M, Imagawa S, Tsunoda J, Furukawa Y, Komatsu N
    Gan to kagaku ryoho. Cancer & chemotherapy 1993年09月
  • [Tumor suppressor genes and their role in abnormal production of leukocytes (leukemogenesis)]
    Furukawa Y
    [Rinsho ketsueki] The Japanese journal of clinical hematology 1993年05月
  • Transforming growth factor-beta inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSK-I.
    Furukawa Y, Uenoyama S, Ohta M, Tsunoda A, Griffin JD, Saito M
    The Journal of biological chemistry 1992年08月
  • [Abnormalities of the retinoblastoma susceptibility gene (RB) in hematologic malignancies].
    Furukawa Y
    Nihon rinsho. Japanese journal of clinical medicine 1992年06月
  • Treatment of myeloid leukemic cells with the phosphatase inhibitor okadaic acid induces cell cycle arrest at either G1/S or G2/M depending on dose.
    Ishida Y, Furukawa Y, Decaprio JA, Saito M, Griffin JD
    Journal of cellular physiology 1992年03月
  • The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.
    DeCaprio JA, Furukawa Y, Ajchenbaum F, Griffin JD, Livingston DM
    Proceedings of the National Academy of Sciences of the United States of America 1992年03月
  • [The role of cell cycle control genes (the retinoblastoma susceptibility gene and cdc2 gene) in proliferation and differentiation of hematopoietic cells].
    Furukawa Y
    Seikagaku. The Journal of Japanese Biochemical Society 1992年02月
  • Heterogeneous expression of the product of the retinoblastoma susceptibility gene in primary human leukemia cells.
    Furukawa Y, DeCaprio JA, Belvin M, Griffin JD
    Oncogene 1991年08月
  • Interleukin 1 production by monocytic leukemia cells and its possible role in coagulation abnormalities.
    Furukawa Y, Ohta M, Miura Y, Saito M
    Leukemia research 1991年01月
  • Cdc2 Gene Expression at the G1 to S Transition in Human T Lymphocytes.
    Furukawa, Y., Piwnica-Worms, H., Ernst, T.J., Kanakura, Y. and Griffin, J.D.
    Science 250 805-808 1990年12月
  • Signal transduction of the human granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins.
    Kanakura Y, Druker B, Cannistra SA, Furukawa Y, Torimoto Y, Griffin JD
    Blood 1990年08月
  • Demonstration of interleukin-1 beta transcripts in acute myeloblastic leukemic cells by in situ hybridization.
    Nakamura M, Kanakura Y, Furukawa Y, Ernst TJ, Griffin JD
    Leukemia 1990年07月
  • Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.
    Furukawa Y, DeCaprio JA, Freedman A, Kanakura Y, Nakamura M, Ernst TJ, Livingston DM, Griffin JD
    Proceedings of the National Academy of Sciences of the United States of America 1990年04月
  • Expression of a novel 3.5-kb macrophage colony-stimulating factor transcript in human myeloma cells.
    Nakamura M, Merchav S, Carter A, Ernst TJ, Demetri GD, Furukawa Y, Anderson K, Freedman AS, Griffin JD
    Journal of immunology (Baltimore, Md. : 1950) 1989年12月
  • The Product of Retinoblastoma Susceptibility Gene Has Properties of a Cell Cycle Regulatory Element.
    DeCaprio, J.A., Ludlow, J.W., Lynch, D., Furukawa, Y., Griffin, J., Piwnica-Worms, H., Huang, C.-M. and Livingston, D.M.
    Cell 58 1085-1095 1989年09月
  • Antileukemic effect of nitrous oxide in a patient with chronic myelogenous leukemia.
    Ikeda K, Aosaki T, Furukawa Y, Ohta M, Kano Y, Tsuboyama A, Sakamoto S, Miura Y, Sakuraya K, Fuke N
    American journal of hematology 1989年02月
  • [Treatment of multiple myeloma: renal function in relation to its prognosis]
    Akashi M, Ohta M, Kitagawa S, Furukawa Y, Takeda K, Muroi K, Komatsu N, Ikeda K, Ohsaka A, Yoshida M
    [Rinsho ketsueki] The Japanese journal of clinical hematology 1988年11月
  • [Primary non-Hodgkin's lymphoma, small lymphocytic type, in the spleen complicating myelodysplastic syndrome].
    Kawashima Y, Furukawa Y, Akutsu M, Yoshida M, Kitagawa S, Sakamoto S, Miura Y
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 1988年07月
  • [Treatment of malignant lymphoma in Jichi Medical School Hospital. 3) Treatment of advanced bad-risk lymphoma with the M-CHOP regimen].
    Furukawa Y, Takagi S, Tsuboyama A, Tsunoda S, Komatsu N, Takeda K, Muroi K, Ohsaka A, Miwa A, Yoshida M
    [Rinsho ketsueki] The Japanese journal of clinical hematology 1988年06月
  • Myelodysplastic syndrome in pregnancy with hematological improvement following delivery.
    Furukawa Y, Enomoto M, Sato Y, Yoshida M, Sakamoto S, Miura Y
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society 1988年02月
  • Cytomegalovirus gastritis as an initial manifestation of a patient with adult T-cell leukemia.
    Furukawa Y, Nakamura H, Sakamoto S, Miura Y
    Acta haematologica 1988年01月
  • [Treatment of malignant lymphoma: 12 years' experience with 109 patients. 2). Treatment of non-Hodgkin's lymphoma].
    Furukawa Y, Takagi S, Tsuboyama A, Tsunoda S, Akashi M, Komatsu N, Takeda K, Muroi K, Akutsu M, Ohsaka A
    [Rinsho ketsueki] The Japanese journal of clinical hematology 1987年09月
  • [Treatment of malignant lymphoma: 12 years' experience with 109 patients. 1). Treatment of Hodgkin's disease].
    Furukawa Y, Takagi S, Tsuboyama A, Akashi M, Komatsu N, Takeda K, Muroi K, Ohsaka A, Ohta M, Suda K
    [Rinsho ketsueki] The Japanese journal of clinical hematology 1987年09月
  • Interleukin-1 derived from human monocytic leukemia cell line JOSK-I acts as an autocrine growth factor.
    Furukawa Y, Ohta M, Miura Y, Saito M
    Biochemical and biophysical research communications 1987年08月
  • Constitutive production of interleukin 1 by human monocytic leukemia cell line JOSK-I and the production mechanism.
    Furukawa Y, Ohta M, Kasahara T, Miura Y, Saito M
    Cancer research 1987年05月
  • [The clinical effect of low-dose Ara-C in patients with refractory acute nonlymphocytic leukemia and myelodysplastic syndrome]
    Yoshida M, Tsunoda S, Akutsu M, Furukawa Y, Takeda K, Akashi M, Komatsu N, Muroi K, Ikeda K, Ohsaka A
    Gan to kagaku ryoho. Cancer & chemotherapy 1987年04月
  • Interleukin-1 producing ability of leukaemia cells and its relationship to morphological diagnosis.
    Furukawa Y, Ohta M, Miura Y, Saito M
    British journal of haematology 1987年01月
  • Myeloid and erythroid lineage expression of haemopoietic progenitors derived from an abnormal clone in erythroleukaemia.
    Suda T, Sato Y, Furukawa Y, Suda J, Eguchi M, Saito M, Miura Y
    British journal of haematology 1986年12月
  • Establishment and characterization of four human monocytoid leukemia cell lines (JOSK-I, -S, -M and -K) with capabilities of monocyte-macrophage lineage differentiation and constitutive production of interleukin 1.
    Ohta M, Furukawa Y, Ide C, Akiyama N, Utakoji T, Miura Y, Saito M
    Cancer research 1986年06月
  • [Essential thrombocythemia--a comparative study on polycythemia vera]
    Ohsaka A, Tsuboyama A, Kano Y, Furukawa Y, Takeda K, Akashi S, Komatsu N, Muroi K, Ohta M, Takagi S
    [Rinsho ketsueki] The Japanese journal of clinical hematology 1986年03月
  • [High-dose cytosine arabinoside administration in the treatment of refractory leukemia]
    Yoshida M, Furukawa Y, Akashi M, Komatsu N, Takeda K, Muroi K, Ikeda K, Ohsaka A, Ohta M, Suda K
    [Rinsho ketsueki] The Japanese journal of clinical hematology 1985年08月
  • [Remission induction failures in adult acute non-lymphocytic leukemia]
    Yoshida M, Furukawa Y, Akashi M, Komatsu N, Takeda K, Muroi K, Ikeda K, Ohsaka A, Ohta M, Takagi S
    [Rinsho ketsueki] The Japanese journal of clinical hematology 1985年06月

受賞

  • 1992年 日本血液学会奨励賞
  • 1997年 日本癌学会奨励賞
  • 2001年 日本白血病基金清水賞
  • 2011年 国際骨髄腫学会堀之内賞
  • 2016年 小林がん学術賞
受賞を全て表示する
受賞閉じる
  • 1992年 日本血液学会奨励賞
  • 1997年 日本癌学会奨励賞
  • 2001年 日本白血病基金清水賞
  • 2011年 国際骨髄腫学会堀之内賞
  • 2016年 小林がん学術賞

外部的資金

  • 血液細胞の分化における細胞周期調節遺伝子の役割
  • 血液細胞における細胞死の機構
  • 血球分化に関与する遺伝子の転写調節機構
  • 造血幹細胞の生物学的特性の解明と臨床応用
    :補助金
  • 分子標的療法の開発と臨床応用
外部資金採択状況を全て表示する
外部資金採択状況閉じる
  • 血液細胞の分化における細胞周期調節遺伝子の役割
  • 血液細胞における細胞死の機構
  • 血球分化に関与する遺伝子の転写調節機構
  • 造血幹細胞の生物学的特性の解明と臨床応用
    :補助金
  • 分子標的療法の開発と臨床応用

Works

  • リジン特異的脱メチル化酵素1阻害活性を有する新規化合物、その製造方法及びその用途
    発表年 : 2017年
  • 多能性幹細胞からのテラトーマ形成抑制剤及びその用途
    発表年 : 2017年
  • プロテアソーム阻害剤
    発表年 : 2011年
  • BIACORE-MASSによる新規P53結合蛋白の同定
    発表年 : 2001年
  • 新しいcDNAサブトラクション法の開始
    発表年 : 1999年
  • エルトリエーターの応用に関する研究
    発表年 : 1996年
Worksを全て表示する
  • リジン特異的脱メチル化酵素1阻害活性を有する新規化合物、その製造方法及びその用途
    発表年 : 2017年
  • 多能性幹細胞からのテラトーマ形成抑制剤及びその用途
    発表年 : 2017年
  • プロテアソーム阻害剤
    発表年 : 2011年
  • BIACORE-MASSによる新規P53結合蛋白の同定
    発表年 : 2001年
  • 新しいcDNAサブトラクション法の開始
    発表年 : 1999年
  • エルトリエーターの応用に関する研究
    発表年 : 1996年


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