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水上 浩明 ミズカミ ヒロアキ

所属部署名遺伝子治療研究部
職名教授ホームページURLhttp://www.jichi.ac.jp/idenshi/index.html

プロフィール

研究キーワード

    血液内科学, ウィルス学, 分子生物学

研究分野

  • 内科系臨床医学 / 内科学一般(含心身医学)

経歴

  • 自治医科大学(JMU)(教授)
  • 1988年
    -
    1990年
    潜水医学実験隊(防衛庁)実験部員
  • 1993年
    -
    1995年
    米国国立保健研究所 客員研究員
  • 1998年
    -
    2003年
    自治医科大学 分子病態治療研究センター 遺伝子治療研究部 助手
  • 2004年
    -
    2011年
    同 講師
  • 2011年
    -
    2014年
    同(准教授)
  • 2014年
    -
    現在
    同 教授

学歴

  • -
    1986年
    防衛医科大学校 医学部(日本)

所属学協会

  • 日本内科学会
  • 日本血液学会
  • 日本遺伝子治療学会
  • 日本ウィルス学会
  • 米国遺伝子治療学会
  • 日本癌学会
  • 欧州遺伝子細胞治療学会
所属学協会を全て表示する
所属学協会閉じる
  • 日本内科学会
  • 日本血液学会
  • 日本遺伝子治療学会
  • 日本ウィルス学会
  • 米国遺伝子治療学会
  • 日本癌学会
  • 欧州遺伝子細胞治療学会

委員歴

  • 2012年
    -
    現在
    日本ウイルス学会 評議員
  • 2003年
    日本遺伝子治療学会 評議員
  • 欧州遺伝子細胞治療学会 会員
  • 日本癌学会 会員
  • 米国遺伝子治療学会 会員
審議会等委員を全て表示する
審議会等委員閉じる
  • 2012年
    -
    現在
    日本ウイルス学会 評議員
  • 2003年
    日本遺伝子治療学会 評議員
  • 欧州遺伝子細胞治療学会 会員
  • 日本癌学会 会員
  • 米国遺伝子治療学会 会員

学位

  • 医学博士

研究活動

論文

  • DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey.
    Hata K, Mizukami H, Sadakane O, Watakabe A, Ohtsuka M, Takaji M, Kinoshita M, Isa T, Ozawa K, Yamamori T
    The Journal of neuroscience : the official journal of the Society for Neuroscience 33 19704-19714 2013年12月
  • Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice.
    Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So KH, Kawada T, Inoue N, Ikeda I, Roh SG, Itoi K, Nishimori K
    Endocrinology 154 4305-4315 2013年11月
  • The prevalence of neutralizing antibodies against adeno-associated virus capsids is reduced in young Japanese individuals.
    Mimuro J, Mizukami H, Shima M, Matsushita T, Taki M, Muto S, Higasa S, Sakai M, Ohmori T, Madoiwa S, Ozawa K, Sakata Y
    Journal of medical virology 2013年10月
  • Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells.
    Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey TE, Suzuki M, Ichimura K, Ozawa K
    Cancer science 2013年10月
  • Fear-enhancing effects of septal oxytocin receptors.
    Guzmán YF, Tronson NC, Jovasevic V, Sato K, Guedea AL, Mizukami H, Nishimori K, Radulovic J
    Nature neuroscience 16 1185-1187 2013年09月
  • Suppression of lymph node and lung metastases of endometrial cancer by muscle-mediated expression of soluble vascular endothelial growth factor receptor-3.
    Takahashi K, Mizukami H, Saga Y, Takei Y, Urabe M, Kume A, Machida S, Fujiwara H, Suzuki M, Ozawa K
    Cancer science 104 1107-1111 2013年08月
  • CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models.
    Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K
    Biochemical and biophysical research communications 438 84-89 2013年08月
  • Overexpression of factor VII ameliorates bleeding diathesis of factor VIII-deficient mice with inhibitors.
    Yasumoto A, Madoiwa S, Kashiwakura Y, Ishiwata A, Ohmori T, Mizukami H, Ozawa K, Sakata Y, Mimuro J
    Thrombosis research 131 444-449 2013年05月
  • Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors.
    Mimuro J, Mizukami H, Hishikawa S, Ikemoto T, Ishiwata A, Sakata A, Ohmori T, Madoiwa S, Ono F, Ozawa K, Sakata Y
    Molecular therapy : the journal of the American Society of Gene Therapy 21 318-323 2013年02月
  • NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.
    Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K
    Cancer research 73 364-372 2013年01月
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論文等(論文)閉じる
  • DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey.
    Hata K, Mizukami H, Sadakane O, Watakabe A, Ohtsuka M, Takaji M, Kinoshita M, Isa T, Ozawa K, Yamamori T
    The Journal of neuroscience : the official journal of the Society for Neuroscience 33 19704-19714 2013年12月
  • Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice.
    Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So KH, Kawada T, Inoue N, Ikeda I, Roh SG, Itoi K, Nishimori K
    Endocrinology 154 4305-4315 2013年11月
  • The prevalence of neutralizing antibodies against adeno-associated virus capsids is reduced in young Japanese individuals.
    Mimuro J, Mizukami H, Shima M, Matsushita T, Taki M, Muto S, Higasa S, Sakai M, Ohmori T, Madoiwa S, Ozawa K, Sakata Y
    Journal of medical virology 2013年10月
  • Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells.
    Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey TE, Suzuki M, Ichimura K, Ozawa K
    Cancer science 2013年10月
  • Fear-enhancing effects of septal oxytocin receptors.
    Guzmán YF, Tronson NC, Jovasevic V, Sato K, Guedea AL, Mizukami H, Nishimori K, Radulovic J
    Nature neuroscience 16 1185-1187 2013年09月
  • Suppression of lymph node and lung metastases of endometrial cancer by muscle-mediated expression of soluble vascular endothelial growth factor receptor-3.
    Takahashi K, Mizukami H, Saga Y, Takei Y, Urabe M, Kume A, Machida S, Fujiwara H, Suzuki M, Ozawa K
    Cancer science 104 1107-1111 2013年08月
  • CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models.
    Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K
    Biochemical and biophysical research communications 438 84-89 2013年08月
  • Overexpression of factor VII ameliorates bleeding diathesis of factor VIII-deficient mice with inhibitors.
    Yasumoto A, Madoiwa S, Kashiwakura Y, Ishiwata A, Ohmori T, Mizukami H, Ozawa K, Sakata Y, Mimuro J
    Thrombosis research 131 444-449 2013年05月
  • Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors.
    Mimuro J, Mizukami H, Hishikawa S, Ikemoto T, Ishiwata A, Sakata A, Ohmori T, Madoiwa S, Ono F, Ozawa K, Sakata Y
    Molecular therapy : the journal of the American Society of Gene Therapy 21 318-323 2013年02月
  • NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.
    Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K
    Cancer research 73 364-372 2013年01月
  • Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein.
    Shimada M, Abe S, Takahashi T, Shiozaki K, Okuda M, Mizukami H, Klinman DM, Ozawa K, Okuda K
    PloS one 8 e57606 2013年
  • An R132H mutation in isocitrate dehydrogenase 1 enhances p21 expression and inhibits phosphorylation of retinoblastoma protein in glioma cells.
    Miyata S, Urabe M, Gomi A, Nagai M, Yamaguchi T, Tsukahara T, Mizukami H, Kume A, Ozawa K, Watanabe E
    Neurologia medico-chirurgica 53 645-654 2013年
  • Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation.
    Sato N, Saga Y, Mizukami H, Wang D, Takahashi S, Nonaka H, Fujiwara H, Takei Y, Machida S, Takikawa O, Ozawa K, Suzuki M
    Oncology reports 28 1574-1578 2012年11月
  • Cetuximab inhibits the growth of mucinous ovarian carcinoma tumor cells lacking KRAS gene mutations.
    Sato N, Saga Y, Mizukami H, Wang D, Fujiwara H, Takei Y, Machida S, Ozawa K, Suzuki M
    Oncology reports 27 1336-1340 2012年05月
  • Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy.
    Wang D, Saga Y, Mizukami H, Sato N, Nonaka H, Fujiwara H, Takei Y, Machida S, Takikawa O, Ozawa K, Suzuki M
    International journal of oncology 40 929-934 2012年04月
  • Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy.
    Yagi H, Sanechika S, Ichinose H, Sumi-Ichinose C, Mizukami H, Urabe M, Ozawa K, Kume A
    Neuroreport 23 30-34 2012年01月
  • Efficient establishment of pig embryonic fibroblast cell lines with conditional expression of the simian vacuolating virus 40 large T fragment.
    Fukuda T, Katayama M, Yoshizawa T, Eitsuka T, Mizukami H, Nakagawa K, Ito H, Komagata H, Song S, Roh S, Hoshino Y, Sato E, Hanada H, Nishimori K, Miyazawa T, Uchida T
    Bioscience, biotechnology, and biochemistry 76 1372-1377 2012年
  • Development of a mouse model for lymph node metastasis with endometrial cancer.
    Takahashi K, Saga Y, Mizukami H, Takei Y, Urabe M, Kume A, Suzuki M, Ozawa K
    Cancer science 102 2272-2277 2011年12月
  • Selective optical control of synaptic transmission in the subcortical visual pathway by activation of viral vector-expressed halorhodopsin.
    Kaneda K, Kasahara H, Matsui R, Katoh T, Mizukami H, Ozawa K, Watanabe D, Isa T
    PloS one 6 e18452 2011年04月
  • Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno-associated virus vector.
    Yagi H, Ogura T, Mizukami H, Urabe M, Hamada H, Yoshikawa H, Ozawa K, Kume A
    The journal of gene medicine 13 114-122 2011年02月
  • Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material.
    Lock M, McGorray S, Auricchio A, Ayuso E, Beecham EJ, Blouin-Tavel V, Bosch F, Bose M, Byrne BJ, Caton T, Chiorini JA, Chtarto A, Clark KR, Conlon T, Darmon C, Doria M, Douar A, Flotte TR, Francis JD, Francois A, Giacca M, Korn MT, Korytov I, Leon X, Leuchs B, Lux G, Melas C, Mizukami H, Moullier P, Müller M, Ozawa K, Philipsberg T, Poulard K, Raupp C, Rivière C, Roosendaal SD, Samulski RJ, Soltys SM, Surosky R, Tenenbaum L, Thomas DL, van Montfort B, Veres G, Wright JF, Xu Y, Zelenaia O, Zentilin L, Snyder RO
    Human gene therapy 21 1273-1285 2010年10月
  • A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease.
    Muramatsu S, Fujimoto K, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I
    Molecular therapy : the journal of the American Society of Gene Therapy 18 1731-1735 2010年09月
  • Mutant macaque factor IX T262A: a tool for hemophilia B gene therapy studies in macaques.
    Ishiwata A, Mimuro J, Mizukami H, Kashiwakura Y, Yasumoto A, Sakata A, Ohmori T, Madoiwa S, Ono F, Shima M, Yoshioka A, Ozawa K, Sakata Y
    Thrombosis research 125 533-537 2010年06月
  • A convenient enzyme-linked immunosorbent assay for rapid screening of anti-adeno-associated virus neutralizing antibodies.
    Ito T, Yamamoto S, Hayashi T, Kodera M, Mizukami H, Ozawa K, Muramatsu S
    Annals of clinical biochemistry 46 508-510 2009年11月
  • Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice.
    Ishiwata A, Mimuro J, Mizukami H, Kashiwakura Y, Takano K, Ohmori T, Madoiwa S, Ozawa K, Sakata Y
    The journal of gene medicine 11 1020-1029 2009年11月
  • The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2.
    Kuratomi S, Ohmori Y, Ito M, Shimazaki K, Muramatsu S, Mizukami H, Uosaki H, Yamashita JK, Arai Y, Kuwahara K, Takano M
    Cardiovascular research 83 682-687 2009年09月
  • Generation of adeno-associated virus vector enabling functional expression of oxytocin receptor and fluorescence marker genes using the human eIF4G internal ribosome entry site element.
    Sato K, Date S, Aoyagi Y, Kasahara Y, Nawa A, Mizukami H, Hidema S, Ozawa K, Nishimori K
    Bioscience, biotechnology, and biochemistry 73 2145-2148 2009年09月
  • Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy.
    Uchibori R, Okada T, Ito T, Urabe M, Mizukami H, Kume A, Ozawa K
    The journal of gene medicine 11 373-381 2009年05月
  • Cell and gene therapy using mesenchymal stem cells (MSCs).
    Ozawa K, Sato K, Oh I, Ozaki K, Uchibori R, Obara Y, Kikuchi Y, Ito T, Okada T, Urabe M, Mizukami H, Kume A
    Journal of autoimmunity 30 121-127 2008年05月
  • Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats.
    Nonaka-Sarukawa M, Okada T, Ito T, Yamamoto K, Yoshioka T, Nomoto T, Hojo Y, Shimpo M, Urabe M, Mizukami H, Kume A, Ikeda U, Shimada K, Ozawa K
    The journal of gene medicine 10 368-374 2008年04月
  • Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea.
    Liu Y, Okada T, Shimazaki K, Sheykholeslami K, Nomoto T, Muramatsu S, Mizukami H, Kume A, Xiao S, Ichimura K, Ozawa K
    Molecular therapy : the journal of the American Society of Gene Therapy 16 474-480 2008年03月
  • Adeno-associated virus vector-mediated production of hepatocyte growth factor attenuates liver fibrosis in mice.
    Suzumura K, Hirano T, Son G, Iimuro Y, Mizukami H, Ozawa K, Fujimoto J
    Hepatology international 2 80-88 2008年03月
  • Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice.
    Takei Y, Saga Y, Mizukami H, Takayama T, Ohwada M, Ozawa K, Suzuki M
    Molecular cancer therapeutics 7 704-711 2008年03月
  • Protection Against Aminoglycoside-induced Ototoxicity by Regulated AAV Vector-mediated GDNF Gene Transfer Into the Cochlea.
    Liu, Y., Okada, T., Shimazaki, K., Sheykholeslami, K., Nomoto, T., Muramatsu, SI., Mizukami, H., Kume, A., Xiao, S., Ichimura, K., Ozawa, K.
    Mol Ther 16 474-80 2008年
  • Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice.
    Takei, Y., Saga, Y., Mizukami, H., Takayama, T., Ohwada, M., Ozawa, K., Suzuki, M.
    Mol Cancer Ther 7 704-11 2008年
  • Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats.
    Nonaka-Sarukawa, M., Okada, T., Ito, T., Yamamoto, K., Yoshioka, T., Nomoto, T., Hojo, Y., Shimpo, M., Urabe, M., Mizukami, H., Kume, A., Ikeda, U., Shimada, K., Ozawa, K.
    J Gene Med 10 368-74 2008年
  • Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.
    Ito T, Okada T, Miyashita H, Nomoto T, Nonaka-Sarukawa M, Uchibori R, Maeda Y, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Shimada K, Ozawa K
    Circulation research 101 734-741 2007年09月
  • Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector.
    Takei Y, Mizukami H, Saga Y, Yoshimura I, Hasumi Y, Takayama T, Kohno T, Matsushita T, Okada T, Kume A, Suzuki M, Ozawa K
    International journal of cancer. Journal international du cancer 120 278-284 2007年01月
  • Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.
    Ideno J, Mizukami H, Kakehashi A, Saito Y, Okada T, Urabe M, Kume A, Kuroki M, Kawakami M, Ishibashi S, Ozawa K
    International journal of molecular medicine 19 75-79 2007年01月
  • Tendon healing in vitro: adeno-associated virus-2 effectively transduces intrasynovial tenocytes with persistent expression of the transgene, but other serotypes do not.
    Wang XT, Liu PY, Tang JB, Mizukami H, Xin KQ, Ozawa K, Ushijima H
    Plastic and reconstructive surgery 119 227-234 2007年01月
  • Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.
    Ito, T., Okada, T., Miyashita, H., Nomoto, T., Nonaka-Sarukawa, M., Uchibori, R., Maeda, Y., Urabe, M., Mizukami, H., Kume, A., Takahashi, M., Ikeda, U., Shimada, K., Ozawa, K.
    Circ Res 101 734-41 2007年
  • Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats.
    Ito, T., Okada, T., Mimuro, J., Miyashita, H., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Takahashi, M., Ikeda, U., Sakata, Y., Shimada, K., Ozawa, K.
    Hypertension 50 531-6 2007年
  • Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector.
    Takei, Y., Mizukami, H., Saga, Y., Yoshimura, I., Hasumi, Y., Takayama, T., Kohno, T., Matsushita, T., Okada, T., Kume, A., Suzuki, M., Ozawa, K.
    Int J Cancer 120 278-84 2007年
  • Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.
    Ideno, J., Mizukami, H., Kakehashi, A., Saito, Y., Okada, T., Urabe, M., Kume, A., Kuroki, M., Kawakami, M., Ishibashi, S., Ozawa, K.
    Int J Mol Med 19 75-9 2007年
  • Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.
    Xin KQ, Mizukami H, Urabe M, Toda Y, Shinoda K, Yoshida A, Oomura K, Kojima Y, Ichino M, Klinman D, Ozawa K, Okuda K
    Journal of virology 80 11899-11910 2006年12月
  • Adipose tissue as a novel target for in vivo gene transfer by adeno-associated viral vectors.
    Mizukami H, Mimuro J, Ogura T, Okada T, Urabe M, Kume A, Sakata Y, Ozawa K
    Human gene therapy 17 921-928 2006年09月
  • Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer.
    Ogura T, Mizukami H, Mimuro J, Madoiwa S, Okada T, Matsushita T, Urabe M, Kume A, Hamada H, Yoshikawa H, Sakata Y, Ozawa K
    The journal of gene medicine 8 990-997 2006年08月
  • A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells.
    Okada T, Uchibori R, Iwata-Okada M, Takahashi M, Nomoto T, Nonaka-Sarukawa M, Ito T, Liu Y, Mizukami H, Kume A, Kobayashi E, Ozawa K
    Molecular therapy : the journal of the American Society of Gene Therapy 13 738-746 2006年04月
  • Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression.
    Urabe M, Xin KQ, Obara Y, Nakakura T, Mizukami H, Kume A, Okuda K, Ozawa K
    Molecular therapy : the journal of the American Society of Gene Therapy 13 823-828 2006年04月
  • Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells.
    Urabe M, Nakakura T, Xin KQ, Obara Y, Mizukami H, Kume A, Kotin RM, Ozawa K
    Journal of virology 80 1874-1885 2006年02月
  • The induction of robust immune responses against HIV is supported by the inherent tropism of AAV5 for DC.
    Xin, KQ., Mizukami, H., Urabe, M., Toda, Y., Shinoda, K., Yoshida, A., Oomura, K., Kojima, Y., Ichino, M., Klinman, D., Ozawa K., and Okuda, K.
    J Virol 80 11899-910 2006年
  • Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer.
    Ogura, T., Mizukami, H., Mimuro, J., Madoiwa, S., Okada, T., Matsushita, T., Urabe, M., Kume, A., Hamada, H., Yoshikawa, H., Sakata, Y., Ozawa, K.
    J Gene Med 8 990-7 2006年
  • Adipose tissue as a novel target for in vivo gene transfer by using adeno-associated virus vectors.
    Mizukami, H., Mimuro, J., Ogura, T., Okada, T., Urabe, M., Kume, A., Sakata, Y., Ozawa, K.
    Hum Gene Ther 17 921-8 2006年
  • Phenotype correction of hemophilia A mice with adeno-associated virus vectors carrying the B domain-deleted canine factor VIII gene.
    Ishiwata A, Mimuro J, Kashiwakura Y, Niimura M, Takano K, Ohmori T, Madoiwa S, Mizukami H, Okada T, Naka H, Yoshioka A, Ozawa K, Sakata Y
    Thrombosis research 118 627-635 2006年
  • Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector.
    Hiraide A, Yokoo N, Xin KQ, Okuda K, Mizukami H, Ozawa K, Saito T
    Human gene therapy 16 1413-1421 2005年12月
  • Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.
    Liu Y, Okada T, Sheykholeslami K, Shimazaki K, Nomoto T, Muramatsu S, Kanazawa T, Takeuchi K, Ajalli R, Mizukami H, Kume A, Ichimura K, Ozawa K
    Molecular therapy : the journal of the American Society of Gene Therapy 12 725-733 2005年10月
  • Large-scale production of recombinant viruses by use of a large culture vessel with active gassing.
    Okada T, Nomoto T, Yoshioka T, Nonaka-Sarukawa M, Ito T, Ogura T, Iwata-Okada M, Uchibori R, Shimazaki K, Mizukami H, Kume A, Ozawa K
    Human gene therapy 16 1212-1218 2005年10月
  • Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.
    Maruyama M, Higuchi M, Takaki Y, Matsuba Y, Tanji H, Nemoto M, Tomita N, Matsui T, Iwata N, Mizukami H, Muramatsu S, Ozawa K, Saido TC, Arai H, Sasaki H
    Annals of neurology 57 832-842 2005年06月
  • Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro.
    Takei Y, Mizukami H, Saga Y, Kobayashi H, Suzuki M, Matsushita T, Ozawa K, Suzuki M
    International journal of cancer. Journal international du cancer 113 54-58 2005年01月
  • Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector.
    Yokoo N, Saito T, Uesugi M, Kobayashi N, Xin KQ, Okuda K, Mizukami H, Ozawa K, Koshino T
    Arthritis and rheumatism 52 164-170 2005年01月
  • Overexpression of a hybrid gene consisting of the amino-terminal fragment of urokinase and carboxyl-terminal domain of bikunin suppresses invasion and migration of human ovarian cancer cells in vitro.
    Takei, Y., Mizukami, H., Saga, Y., Kobayashi, H., Suzuki, M., Matsushita, T., Ozawa, K., Suzuki, M.
    Int J Cancer 113 54-8 2005年
  • Sustained transgene expression by human cord blood derived CD34+ cells transduced with simian immunodeficiency virus agmTYO1-based vectors carrying the human coagulation factor VIII gene in NOD/SCID mice.
    Kikuchi J, Mimuro J, Ogata K, Tabata T, Ueda Y, Ishiwata A, Kimura K, Takano K, Madoiwa S, Mizukami H, Hanazono Y, Kume A, Hasegawa M, Ozawa K, Sakata Y
    The journal of gene medicine 6 1049-1060 2004年10月
  • Topoisomerase inhibitors enhance the cytocidal effect of AAV-HSVtk/ganciclovir on head and neck cancer cells.
    Kanazawa T, Mizukami H, Nishino H, Okada T, Hanazono Y, Kume A, Kitamura K, Ichimura K, Ozawa K
    International journal of oncology 25 729-735 2004年09月
  • The adenovirus E1A and E1B19K genes provide a helper function for transfection-based adeno-associated virus vector production.
    Matsushita T, Okada T, Inaba T, Mizukami H, Ozawa K, Colosi P
    The Journal of general virology 85 2209-2214 2004年08月
  • Is fenestration a safe treatment for adult polycystic liver disease?: A report of refractory complications.
    Ishibashi K, Midorikawa T, Kikuchi H, Fujiwara Y, Izuno H, Hatakeyama T, Saito M, Miyakawa K, Mizukami H, Maezawa K, Nemoto H, Sanada Y
    Hepato-gastroenterology 51 1165-1167 2004年07月
  • Separate control of Rep and Cap expression using mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.
    Mizukami H, Okada T, Ogasawara Y, Matsushita T, Urabe M, Kume A, Ozawa K
    Molecular biotechnology 27 7-14 2004年05月
  • Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.
    Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC
    The Journal of neuroscience : the official journal of the Society for Neuroscience 24 991-998 2004年01月
  • Long-term correction of hyperphenylalaninemia by AAV-mediated gene transfer leads to behavioral recovery in phenylketonuria mice.
    Mochizuki, S., Mizukami, H., Ogura, T., Kure, S., Ichinohe, A., Kojima, K., Matsubara, Y., Kobayashi, E., Okada, T., Hoshika, A., Ozawa, K., Kume, A.
    Gene Ther 11 1081-6 2004年
  • Separate control of Rep and Cap expression utilizing mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.
    Mizukami, H., Okada, T., Ogasawara, Y., Matsushita, T., Urabe, M., Kume, A., and Ozawa, K.
    Mol Biotechnol 27 7-14 2004年
  • Successful gene transfer using adeno-associated virus vectors into the kidney: comparison among adeno-associated virus serotype 1-5 vectors in vitro and in vivo.
    Takeda S, Takahashi M, Mizukami H, Kobayashi E, Takeuchi K, Hakamata Y, Kaneko T, Yamamoto H, Ito C, Ozawa K, Ishibashi K, Matsuzaki T, Takata K, Asano Y, Kusano E
    Nephron. Experimental nephrology 96 e119-26 2004年
  • Persistent phenotypic correction of central diabetes insipidus using adeno-associated virus vector expressing arginine-vasopressin in Brattleboro rats.
    Ideno J, Mizukami H, Honda K, Okada T, Hanazono Y, Kume A, Saito T, Ishibashi S, Ozawa K
    Molecular therapy : the journal of the American Society of Gene Therapy 8 895-902 2003年12月
  • A soluble CAR-SCF fusion protein improves adenoviral vector-mediated gene transfer to c-Kit-positive hematopoietic cells.
    Itoh A, Okada T, Mizuguchi H, Hayakawa T, Mizukami H, Kume A, Takatoku M, Komatsu N, Hanazono Y, Ozawa K
    The journal of gene medicine 5 929-940 2003年11月
  • Suppression of cell migration in ovarian cancer cells mediated by PTEN overexpression.
    Saga Y, Mizukami H, Takei Y, Ozawa K, Suzuki M
    International journal of oncology 23 1109-1113 2003年10月
  • Overexpression of thymidylate synthase mediates desensitization for 5-fluorouracil of tumor cells.
    Saga Y, Suzuki M, Mizukami H, Kohno T, Takei Y, Fukushima M, Ozawa K
    International journal of cancer. Journal international du cancer 106 324-326 2003年09月
  • Interleukin-10-mediated inhibition of angiogenesis and tumor growth in mice bearing VEGF-producing ovarian cancer.
    Kohno T, Mizukami H, Suzuki M, Saga Y, Takei Y, Shimpo M, Matsushita T, Okada T, Hanazono Y, Kume A, Sato I, Ozawa K
    Cancer research 63 5091-5094 2003年08月
  • Reduction of CTLL-2 cytotoxicity by induction of apoptosis with a Fas-estrogen receptor chimera.
    Kametaka M, Kume A, Okada T, Mizukami H, Hanazono Y, Ozawa K
    Cancer science 94 639-643 2003年07月
  • A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV.
    Xin KQ, Ooki T, Jounai N, Mizukami H, Hamajima K, Kojima Y, Ohba K, Toda Y, Hirai S, Klinman DM, Ozawa K, Okuda K
    The journal of gene medicine 5 438-445 2003年05月
  • Distinct patterns of gene transfer to gerbil hippocampus with recombinant adeno-associated virus type 2 and 5.
    Nomoto T, Okada T, Shimazaki K, Mizukami H, Matsushita T, Hanazono Y, Kume A, Katsura K, Katayama Y, Ozawa K
    Neuroscience letters 340 153-157 2003年04月
  • In vivo expansion of transduced murine hematopoietic cells with a selective amplifier gene.
    Kume A, Koremoto M, Xu R, Okada T, Mizukami H, Hanazono Y, Hasegawa M, Ozawa K
    The journal of gene medicine 5 175-181 2003年03月
  • Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport.
    Lu YY, Wang LJ, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I
    Neuroscience research 45 33-40 2003年01月
  • Selective expansion of transduced cells for hematopoietic stem cell gene therapy.
    Kume A, Hanazono Y, Mizukami H, Okada T, Ozawa K
    International journal of hematology 76 299-304 2002年11月
  • Gene marking in adeno-associated virus vector infected periosteum derived cells for cartilage repair.
    Kobayashi N, Koshino T, Uesugi M, Yokoo N, Xin KQ, Okuda K, Mizukami H, Ozawa K, Saito T
    The Journal of rheumatology 29 2176-2180 2002年10月
  • Adeno-associated virus vectors for gene transfer to the brain.
    Okada T, Nomoto T, Shimazaki K, Lijun W, Lu Y, Matsushita T, Mizukami H, Urabe M, Hanazono Y, Kume A, Muramatsu S, Nakano I, Ozawa K
    Methods (San Diego, Calif.) 28 237-247 2002年10月
  • Oral administration of recombinant adeno-associated virus elicits human immunodeficiency virus-specific immune responses.
    Xin KQ, Ooki T, Mizukami H, Hamajima K, Okudela K, Hashimoto K, Kojima Y, Jounai N, Kumamoto Y, Sasaki S, Klinman D, Ozawa K, Okuda K
    Human gene therapy 13 1571-1581 2002年09月
  • Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.
    Wang LJ, Lu YY, Muramatsu S, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Matsushita T, Hanazono Y, Kume A, Nagatsu T, Ozawa K, Nakano I
    The Journal of neuroscience : the official journal of the Society for Neuroscience 22 6920-6928 2002年08月
  • Overexpression of PTEN increases sensitivity to SN-38, an active metabolite of the topoisomerase I inhibitor irinotecan, in ovarian cancer cells.
    Saga Y, Mizukami H, Suzuki M, Kohno T, Urabe M, Ozawa K, Sato I
    Clinical cancer research : an official journal of the American Association for Cancer Research 8 1248-1252 2002年05月
  • Soluble FLT-1 expression suppresses carcinomatous ascites in nude mice bearing ovarian cancer.
    Hasumi Y, Mizukami H, Urabe M, Kohno T, Takeuchi K, Kume A, Momoeda M, Yoshikawa H, Tsuruo T, Shibuya M, Taketani Y, Ozawa K
    Cancer research 62 2019-2023 2002年04月
  • AAV-mediated VEGF gene transfer into skeletal muscle stimulates angiogenesis and improves blood flow in a rat hindlimb ischemia model.
    Shimpo M, Ikeda U, Maeda Y, Takahashi M, Miyashita H, Mizukami H, Urabe M, Kume A, Takizawa T, Shibuya M, Ozawa K, Shimada K
    Cardiovascular research 53 993-1001 2002年03月
  • Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes.
    Muramatsu S, Fujimoto K, Ikeguchi K, Shizuma N, Kawasaki K, Ono F, Shen Y, Wang L, Mizukami H, Kume A, Matsumura M, Nagatsu I, Urano F, Ichinose H, Nagatsu T, Terao K, Nakano I, Ozawa K
    Human gene therapy 13 345-354 2002年02月
  • Adeno-associated viral vector-mediated gene therapy of ischemia-induced neuronal death.
    Okada T, Shimazaki K, Nomoto T, Matsushita T, Mizukami H, Urabe M, Hanazono Y, Kume A, Tobita K, Ozawa K, Kawai N
    Methods in enzymology 346 378-393 2002年
  • Enhanced expression of thymidylate synthase mediates resistance of uterine cervical cancer cells to radiation.
    Saga Y, Suzuki M, Mizukami H, Urabe M, Fukushima M, Ozawa K, Sato I
    Oncology 63 185-191 2002年

書籍等出版物

  • 『糖尿病学ー基礎と臨床』
    西村書店 2007年 ISBN:978-4-89013-355-0
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  • 『糖尿病学ー基礎と臨床』
    西村書店 2007年 ISBN:978-4-89013-355-0

外部的資金

  • 1. 遺伝子導入に関連する分子基盤とin vivoにおける組織特異性の解明 2. AAV各血清型に由来するベクターの特性の解明 3. 導入遺伝子産物に対する免疫反応の解析とその制御 4. ベクターに対する免疫反応が遺伝子導入に与える影響の解析 5. 血友病・悪性腫瘍・神経疾患などに対する新規治療法の開発
    :厚生労働科学研究費補助金
外部資金採択状況を全て表示する
外部資金採択状況閉じる
  • 1. 遺伝子導入に関連する分子基盤とin vivoにおける組織特異性の解明 2. AAV各血清型に由来するベクターの特性の解明 3. 導入遺伝子産物に対する免疫反応の解析とその制御 4. ベクターに対する免疫反応が遺伝子導入に与える影響の解析 5. 血友病・悪性腫瘍・神経疾患などに対する新規治療法の開発
    :厚生労働科学研究費補助金


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