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唐澤 直義 カラサワ タダヨシ

所属部署名炎症・免疫研究部
職名助教ホームページURLhttp://kaken.nii.ac.jp/d/r/60631893.ja.html

プロフィール

研究分野

  • 内科系臨床医学 / 代謝学

学位

  • 医学博士

研究活動

論文

  • Serum Mac-2 Binding Protein Glycosylation isomer predicts the activation of hepatic stellate cells after liver transplantation.
    Yamada N, Katano T, Hirata Y, Okada N, Sanada Y, Ihara Y, Urahashi T, Ushijima K, Karasawa T, Takahashi M, Mizuta K
    Journal of gastroenterology and hepatology 2018年08月
  • Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.
    Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, Ohno N, Kasahara T, Minota S, Takahashi M
    Scientific reports 8(1) 7601 2018年05月
  • Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.
    Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, Takahashi M
    Arteriosclerosis, thrombosis, and vascular biology 38(4) 744-756 2018年04月
  • ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
    Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 199(10) 3614-3622 2017年11月
  • Interaction of Neutrophils with Macrophages Promotes IL-1β Maturation and Contributes to Hepatic Ischemia-Reperfusion Injury.
    Sadatomo A, Inoue Y, Ito H, Karasawa T, Kimura H, Watanabe S, Mizushina Y, Nakamura J, Kamata R, Kasahara T, Horie H, Sata N, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 199(9) 3306-3315 2017年11月
  • Role of NLRP3 Inflammasomes in Atherosclerosis.
    Karasawa T, Takahashi M
    Journal of atherosclerosis and thrombosis 24(5) 443-451 2017年05月
  • The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis.
    Karasawa T, Takahashi M
    Inflammation and regeneration 37 18 2017年
  • The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction.
    Kobayashi M, Usui-Kawanishi F, Karasawa T, Kimura H, Watanabe S, Mise N, Kayama F, Kasahara T, Hasebe N, Takahashi M
    PloS one 12(5) e0176676 2017年
  • Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
    Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M
    American journal of physiology. Endocrinology and metabolism 311(5) E881-E890 2016年11月
  • Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.
    Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T
    Journal of reproductive immunology 116 104-112 2016年08月
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  • Serum Mac-2 Binding Protein Glycosylation isomer predicts the activation of hepatic stellate cells after liver transplantation.
    Yamada N, Katano T, Hirata Y, Okada N, Sanada Y, Ihara Y, Urahashi T, Ushijima K, Karasawa T, Takahashi M, Mizuta K
    Journal of gastroenterology and hepatology 2018年08月
  • Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.
    Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, Ohno N, Kasahara T, Minota S, Takahashi M
    Scientific reports 8(1) 7601 2018年05月
  • Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.
    Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, Takahashi M
    Arteriosclerosis, thrombosis, and vascular biology 38(4) 744-756 2018年04月
  • ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
    Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 199(10) 3614-3622 2017年11月
  • Interaction of Neutrophils with Macrophages Promotes IL-1β Maturation and Contributes to Hepatic Ischemia-Reperfusion Injury.
    Sadatomo A, Inoue Y, Ito H, Karasawa T, Kimura H, Watanabe S, Mizushina Y, Nakamura J, Kamata R, Kasahara T, Horie H, Sata N, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 199(9) 3306-3315 2017年11月
  • Role of NLRP3 Inflammasomes in Atherosclerosis.
    Karasawa T, Takahashi M
    Journal of atherosclerosis and thrombosis 24(5) 443-451 2017年05月
  • The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis.
    Karasawa T, Takahashi M
    Inflammation and regeneration 37 18 2017年
  • The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction.
    Kobayashi M, Usui-Kawanishi F, Karasawa T, Kimura H, Watanabe S, Mise N, Kayama F, Kasahara T, Hasebe N, Takahashi M
    PloS one 12(5) e0176676 2017年
  • Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
    Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M
    American journal of physiology. Endocrinology and metabolism 311(5) E881-E890 2016年11月
  • Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.
    Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T
    Journal of reproductive immunology 116 104-112 2016年08月
  • NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity.
    Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y, Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M
    Scientific reports 6 26489 2016年05月
  • Letter by Karasawa and Takahashi Regarding Article, "Anti-inflammatory and Antiatherogenic Effects of the Inflammasome NLRP3 Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet".
    Karasawa T, Takahashi M
    Circulation 132(21) e249 2015年11月
  • NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy.
    Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M
    Endocrinology 156(11) 4281-4292 2015年11月
  • Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders.
    Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M
    Scientific reports 5 15883 2015年10月
  • Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury.
    Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M
    Scientific reports 5 10901 2015年06月
  • RIP140 as a novel therapeutic target in the treatment of atherosclerosis.
    Karasawa T, Takahashi M
    Journal of molecular and cellular cardiology 81 136-138 2015年04月
  • NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β.
    Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M
    The Journal of biological chemistry 290(8) 5065-5077 2015年02月
  • Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
    Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M
    Arteriosclerosis, thrombosis, and vascular biology 35(1) 127-136 2015年01月
  • Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing.
    Karasawa T, Kawashima A, Usui F, Kimura H, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Sagara J, Takahashi M
    FEBS open bio 5 348-356 2015年
  • Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.
    Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H
    Endocrinology 155(12) 4706-4719 2014年12月
  • Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.
    Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M
    Nanotoxicology 9(5) 1-14 2014年09月
  • ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction.
    Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M
    The American journal of pathology 184(5) 1287-1298 2014年05月
  • NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.
    Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 192(9) 4342-4351 2014年05月
  • Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages.
    Hara K, Shirasuna K, Usui F, Karasawa T, Mizushina Y, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M
    PloS one 9(12) e113974 2014年
  • Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice.
    Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Hida S, Sagara J, Taniguchi S, Takahashi M
    Biochemical and biophysical research communications 425(2) 162-168 2012年08月
  • Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice.
    Kumadaki S, Karasawa T, Matsuzaka T, Ema M, Nakagawa Y, Nakakuki M, Saito R, Yahagi N, Iwasaki H, Sone H, Takekoshi K, Yatoh S, Kobayashi K, Takahashi A, Suzuki H, Takahashi S, Yamada N, Shimano H
    The Journal of biological chemistry 286(47) 40835-40846 2011年11月
  • Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
    Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, Matsumori R, Ishii K, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Sone H, Suzuki H, Yahagi N, Yamada N, Shimano H
    Arteriosclerosis, thrombosis, and vascular biology 31(9) 1973-1979 2011年09月
  • Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice.
    Karasawa T, Takahashi A, Saito R, Sekiya M, Igarashi M, Iwasaki H, Miyahara S, Koyasu S, Nakagawa Y, Ishii K, Matsuzaka T, Kobayashi K, Yahagi N, Takekoshi K, Sone H, Yatoh S, Suzuki H, Yamada N, Shimano H
    Arteriosclerosis, thrombosis, and vascular biology 31(8) 1788-1795 2011年08月
  • Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
    Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N
    Nature medicine 13(10) 1193-1202 2007年10月

特許

  • 高分子化環状ニトロキシドラジカル化合物の経口投与用製剤
    長崎 幸夫, 吉冨 徹, 尾崎 佑樹, ペンナパー ションパトンピクンラット, 島野 仁, 松坂 賢, 唐澤 直義
    特願2012-0199752012年02月01日

外部的資金

  • 脂質代謝経路への介入による新規の自然炎症制御方法の確立
    文部科学省:科学研究費補助金(若手研究(B))
    研究期間 :2014年 - 2015年 代表者 : 唐澤 直義
  • インフラマソームの生活習慣病の病態における役割の解明とその新規制御法の確立
    文部科学省:科学研究費補助金(研究活動スタート支援)
    研究期間 :2012年 - 2013年 代表者 : 唐澤 直義
外部資金採択状況を全て表示する
外部資金採択状況閉じる
  • 脂質代謝経路への介入による新規の自然炎症制御方法の確立
    文部科学省:科学研究費補助金(若手研究(B))
    研究期間 :2014年 - 2015年 代表者 : 唐澤 直義
  • インフラマソームの生活習慣病の病態における役割の解明とその新規制御法の確立
    文部科学省:科学研究費補助金(研究活動スタート支援)
    研究期間 :2012年 - 2013年 代表者 : 唐澤 直義


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