toyoshima hideo

FacultyComprehensiveMedicine1
Job titleAssociate ProfessorWeb site

Profile

Research Areas

  • Biological science / Cell biology
  • Clinical internal medicine / Metabolomics

Career

  • 1990
    -
    1996
     Assistant Professor, Faculty of Medicine,University of Tokyo

Academic Background

  • -
    1985
    Faculty of Medicine, The University of Tokyo (japan)

Research Activities

Papers(other)

  • p57Kip2 is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor β1.
    URANO T, YASHIRODA H, MURAOKA M, TANAKA K, HOSOI T, INOUE S, OUCHI Y, TANAKA K, TOYOSHIMA H
    Journal of Biological Chemistry 274(18) 12197-12200 1999
  • Inctivation of p27Kip1 by the viral E1A oncoprotein in TGF β-treated cells.
    MAL A, POON R Y C, HOWE P H, TOYOSHIMA H, HUNTER T, HARTER M L
    Nature 380(6571) 262-265 1996
  • p27, a novelinhibitor of G1 cyclin-Cdk protein kinase activity, is related to P21.
    TOYOSHIMA H, HUNTER T
    Cell 78(1) 67-74 1994
  • Role of cyclin A and p27 in anti-IgM-induced G1 growth arrest of murine B-cell lymphomas.
    EZHEVSKY S A, TOYOSHIMA H, HUNTER T, SCOTT D W
    Molecular Biology of the Cell 7(4) 553-564 1996
  • Cyclin-dependent Kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.
    POON R Y C, JIANG W, TOYOSHIMA H, HUNTER T
    Journal of Biological Chemistry 271(22) 13283-13291 1996
  • Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.
    POON R Y C, JIANG W, TOYOSHIMA H, HUNTER T
    Journal of Biological Chemistry 271(22) 13283-13291 1996
  • Redistribution of the CDK inhibitor p27 between different cyclin・CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.
    Molecular Biology of the Cell 6 1197-1213 1995
  • Differently spliced cDNAs of human ltk receptor tyrosine kinase predict receptor proteins with and without tyrosine kinase domain and a soluble receptor protein.
    TOYOSHIMA H, KOZUTSUMI H, MARU Y, HAGIWARA K, FURUYA A, MIOH H, HANAI N, TAKAKU F, HIRAI H
    Proceedings of the National Academy of Sciences of the United States of America 90(12) 5404-5408 1993
  • Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and trnsport of unspliced RNAs.
    Journal of Virology 64 2825-2832 1990
  • Smad-mediated Transcription Is Required for Transforming Growth Factor-β1-induced p57Kip2 Proteolysis in Osteoblastic Cells
    NISHIMORI S, TANAKA Y, CHIBA T, FUJII M, MIYAZONO K, OGASAWARA T, KAWAGUCHI H, IGARASHI T, TOYOSHIMA H
    The Journal of Biological Chemistry 276(14) 10700-10705 2001
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Papers(other)close
  • p57Kip2 is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor β1.
    URANO T, YASHIRODA H, MURAOKA M, TANAKA K, HOSOI T, INOUE S, OUCHI Y, TANAKA K, TOYOSHIMA H
    Journal of Biological Chemistry 274(18) 12197-12200 1999
  • Inctivation of p27Kip1 by the viral E1A oncoprotein in TGF β-treated cells.
    MAL A, POON R Y C, HOWE P H, TOYOSHIMA H, HUNTER T, HARTER M L
    Nature 380(6571) 262-265 1996
  • p27, a novelinhibitor of G1 cyclin-Cdk protein kinase activity, is related to P21.
    TOYOSHIMA H, HUNTER T
    Cell 78(1) 67-74 1994
  • Role of cyclin A and p27 in anti-IgM-induced G1 growth arrest of murine B-cell lymphomas.
    EZHEVSKY S A, TOYOSHIMA H, HUNTER T, SCOTT D W
    Molecular Biology of the Cell 7(4) 553-564 1996
  • Cyclin-dependent Kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.
    POON R Y C, JIANG W, TOYOSHIMA H, HUNTER T
    Journal of Biological Chemistry 271(22) 13283-13291 1996
  • Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.
    POON R Y C, JIANG W, TOYOSHIMA H, HUNTER T
    Journal of Biological Chemistry 271(22) 13283-13291 1996
  • Redistribution of the CDK inhibitor p27 between different cyclin・CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.
    Molecular Biology of the Cell 6 1197-1213 1995
  • Differently spliced cDNAs of human ltk receptor tyrosine kinase predict receptor proteins with and without tyrosine kinase domain and a soluble receptor protein.
    TOYOSHIMA H, KOZUTSUMI H, MARU Y, HAGIWARA K, FURUYA A, MIOH H, HANAI N, TAKAKU F, HIRAI H
    Proceedings of the National Academy of Sciences of the United States of America 90(12) 5404-5408 1993
  • Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and trnsport of unspliced RNAs.
    Journal of Virology 64 2825-2832 1990
  • Smad-mediated Transcription Is Required for Transforming Growth Factor-β1-induced p57Kip2 Proteolysis in Osteoblastic Cells
    NISHIMORI S, TANAKA Y, CHIBA T, FUJII M, MIYAZONO K, OGASAWARA T, KAWAGUCHI H, IGARASHI T, TOYOSHIMA H
    The Journal of Biological Chemistry 276(14) 10700-10705 2001

Outside Fund Adoption

  • Cell Differentiation and Cell Cycle in Atherosclerosis
    :The Other Research Programs
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Outside Fund Adoptionclose
  • Cell Differentiation and Cell Cycle in Atherosclerosis
    :The Other Research Programs


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