kimura hiroaki

FacultyDoctorCourseofMedicalScienceProgramsofClinicalandCommunityMedicineDivisionofHematologyandClinicalImmunologyInflammationandImmunology
Job titleAssistant ProfessorWeb site

Profile

Research Keywords

    autoimmune diseases, obesity

Research Areas

  • Basic medicine / Immunology / immunoproteasome
  • Clinical internal medicine / Endocrinology

Career

  • Jul.2008
    -
    May2010
    The Johns Hopkins Medical Institutions Dept of Pathology, research associate
  • Jul.2001
    -
    Jun.2008
    The Johns Hopkins Medical Institutions Dept of Pathology, postdoctoral fellow
  • May1998
    -
    Jun.2001
    National Institute of Infectious Diseases Leprosy Research Center

Academic Societies

  • THE JAPAN ENDOCRINE SOCIETY
  • THE JAPANAESE SOCIETY OF INFLAMMATION AND REGENERATION
  • The Endocrine Society
  • American Thyroid Association
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Academic Societiesclose
  • THE JAPAN ENDOCRINE SOCIETY
  • THE JAPANAESE SOCIETY OF INFLAMMATION AND REGENERATION
  • The Endocrine Society
  • American Thyroid Association

Research Activities

Papers(paper)

  • Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
    Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M
    American journal of physiology. Endocrinology and metabolism 311(5) E881-E890 Nov. 2016
  • NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy.
    Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M
    Endocrinology 156(11) 4281-4292 Nov. 2015
  • NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity.
    Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y, Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M
    Scientific reports 6 26489 May 2016
  • Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders.
    Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M
    Scientific reports 5 15883 Oct. 2015
  • Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury.
    Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M
    Scientific reports 5 10901 Jun. 2015
  • Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing.
    Karasawa T, Kawashima A, Usui F, Kimura H, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Sagara J, Takahashi M
    FEBS open bio 5 348-356 Apr. 2015
  • Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
    Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M
    Arteriosclerosis, thrombosis, and vascular biology 35(1) 127-136 Jan. 2015
  • NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β.
    Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M
    The Journal of biological chemistry 290(8) 5065-5077 Feb. 2015
  • Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.
    Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M
    Nanotoxicology 9(5) 554-567 2015
  • Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages.
    Hara K, Shirasuna K, Usui F, Karasawa T, Mizushina Y, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M
    PloS one 9(12) e113974 Dec. 2014
Display all
Papers(paper)close
  • Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
    Kimura H, Karasawa T, Usui F, Kawashima A, Endo Y, Kobayashi M, Sadatomo A, Nakamura J, Iwasaki Y, Yada T, Tsutsui H, Kasahara T, Takahashi M
    American journal of physiology. Endocrinology and metabolism 311(5) E881-E890 Nov. 2016
  • NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy.
    Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M
    Endocrinology 156(11) 4281-4292 Nov. 2015
  • NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity.
    Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y, Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M
    Scientific reports 6 26489 May 2016
  • Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders.
    Kimura H, Usui F, Karasawa T, Kawashima A, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Kasahara T, Suzuki K, Iwasaki Y, Yada T, Caturegli P, Takahashi M
    Scientific reports 5 15883 Oct. 2015
  • Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury.
    Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M
    Scientific reports 5 10901 Jun. 2015
  • Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing.
    Karasawa T, Kawashima A, Usui F, Kimura H, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Sagara J, Takahashi M
    FEBS open bio 5 348-356 Apr. 2015
  • Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
    Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M
    Arteriosclerosis, thrombosis, and vascular biology 35(1) 127-136 Jan. 2015
  • NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β.
    Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M
    The Journal of biological chemistry 290(8) 5065-5077 Feb. 2015
  • Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.
    Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M
    Nanotoxicology 9(5) 554-567 2015
  • Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages.
    Hara K, Shirasuna K, Usui F, Karasawa T, Mizushina Y, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M
    PloS one 9(12) e113974 Dec. 2014
  • New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells.
    Kimura H, Caturegli P, Takahashi M, Suzuki K
    Journal of immunology research 2015 541984 2015
  • ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction.
    Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M
    The American journal of pathology 184(5) 1287-1298 May 2014
  • NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.
    Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M
    Journal of immunology (Baltimore, Md. : 1950) 192(9) 4342-4351 May 2014
  • [Research update on pathogenesis of autoimmune thyroid diseases].
    Suzuki K, Kawashima A, Kimura H
    Nihon rinsho. Japanese journal of clinical medicine 70(11) 1880-1884 Nov. 2012
  • Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice.
    Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Hida S, Sagara J, Taniguchi S, Takahashi M
    Biochemical and biophysical research communications 425(2) 162-168 Aug. 2012
  • Hürthle cells predict hypothyroidism in interferon-γ transgenic mice of different genetic backgrounds.
    Iwama S, De Remigis A, Bishop JA, Kimura HJ, Caturegli P
    Endocrinology 153(8) 4059-4066 Aug. 2012
  • Pituitary and systemic autoimmunity in a case of intrasellar germinoma.
    Gutenberg A, Bell JJ, Lupi I, Tzou SC, Landek-Salgado MA, Kimura H, Su J, Karaviti LP, Salvatori R, Caturegli P
    Pituitary 14(4) 388-394 Dec. 2011
  • Role of thyroglobulin on negative feedback autoregulation of thyroid follicular function and growth.
    Suzuki K, Kawashima A, Yoshihara A, Akama T, Sue M, Yoshida A, Kimura HJ
    The Journal of endocrinology 209(2) 169-174 May 2011
  • Fragments of genomic DNA released by injured cells activate innate immunity and suppress endocrine function in the thyroid.
    Kawashima A, Tanigawa K, Akama T, Wu H, Sue M, Yoshihara A, Ishido Y, Kobiyama K, Takeshita F, Ishii KJ, Hirano H, Kimura H, Sakai T, Ishii N, Suzuki K
    Endocrinology 152(4) 1702-1712 Apr. 2011
  • Pregnancy, postpartum autoimmune thyroiditis, and autoimmune hypophysitis: intimate relationships.
    Landek-Salgado MA, Gutenberg A, Lupi I, Kimura H, Mariotti S, Rose NR, Caturegli P
    Autoimmunity reviews 9(3) 153-157 Jan. 2010
  • Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice.
    Kimura HJ, Chen CY, Tzou SC, Rocchi R, Landek-Salgado MA, Suzuki K, Kimura M, Rose NR, Caturegli P
    PloS one 4(11) e7857 Nov. 2009
  • Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice.
    Usui F, Kimura H, Ohshiro T, Tatsumi K, Kawashima A, Nishiyama A, Iwakura Y, Ishibashi S, Takahashi M
    Biochemical and biophysical research communications 420(1) 72-77 Mar. 2012
  • Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development.
    Xiao Z, Mohamood AS, Uddin S, Gutfreund R, Nakata C, Marshall A, Kimura H, Caturegli P, Womer KL, Huang Y, Jie C, Chakravarti S, Schneck JP, Yagita H, Hamad AR
    The American journal of pathology 179(2) 725-732 Aug. 2011
  • Preparation of mouse pituitary immunogen for the induction of experimental autoimmune hypophysitis.
    Tzou SC, Landek-Salgado MA, Kimura H, Caturegli P
    Journal of visualized experiments : JoVE(46) Dec. 2010
  • Induction of experimental autoimmune hypophysitis in SJL mice.
    Landek-Salgado MA, Tzou SC, Kimura H, Caturegli P
    Journal of visualized experiments : JoVE(46) Dec. 2010
  • Excess iodide decreases transcription of NIS and VEGF genes in rat FRTL-5 thyroid cells.
    Suzuki K, Kimura H, Wu H, Kudo N, Kim WB, Suzuki S, Yoshida A, Caturegli P, Kohn LD
    Biochemical and biophysical research communications 393(2) 286-290 Mar. 2010
  • A nonclassical model of autoimmune hypothyroidism.
    Caturegli P, Kimura H
    Thyroid : official journal of the American Thyroid Association 20(1) 3-5 Jan. 2010
  • Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome.
    Vosters JL, Landek-Salgado MA, Yin H, Swaim WD, Kimura H, Tak PP, Caturegli P, Chiorini JA
    Arthritis and rheumatism 60(12) 3633-3641 Dec. 2009
  • Influence of signal transducer and activator of transcription-1 signaling on thyroid morphology and function.
    Kimura HJ, Rocchi R, Landek-Salgado MA, Suzuki K, Chen CY, Kimura M, Rose NR, Caturegli P
    Endocrinology 150(7) 3409-3416 Jul. 2009
  • Regenerative potentials of the murine thyroid in experimental autoimmune thyroiditis: role of CD24.
    Chen CY, Kimura H, Landek-Salgado MA, Hagedorn J, Kimura M, Suzuki K, Westra W, Rose NR, Caturegli P
    Endocrinology 150(1) 492-499 Jan. 2009
  • Pituitary autoimmunity: 30 years later.
    Caturegli P, Lupi I, Landek-Salgado M, Kimura H, Rose NR
    Autoimmunity reviews 7(8) 631-637 Sep. 2008
  • Autoimmune hypophysitis of SJL mice: clinical insights from a new animal model.
    Tzou SC, Lupi I, Landek M, Gutenberg A, Tzou YM, Kimura H, Pinna G, Rose NR, Caturegli P
    Endocrinology 149(7) 3461-3469 Jul. 2008
  • Chemokine orchestration of autoimmune thyroiditis.
    Kimura H, Caturegli P
    Thyroid : official journal of the American Thyroid Association 17(10) 1005-1011 Oct. 2007
  • Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness.
    Rocchi R, Kimura H, Tzou SC, Suzuki K, Rose NR, Pinchera A, Ladenson PW, Caturegli P
    Proceedings of the National Academy of Sciences of the United States of America 104(14) 6019-6024 Apr. 2007
  • Autoimmune thyroid diseases.
    Caturegli P, Kimura H, Rocchi R, Rose NR
    Current opinion in rheumatology 19(1) 44-48 Jan. 2007
  • Multiple mechanisms involved in the inhibition of proinflammatory cytokine production from human monocytes by N-(p-coumaroyl)serotonin and its derivatives.
    Takii T, Kawashima S, Chiba T, Hayashi H, Hayashi M, Hiroma H, Kimura H, Inukai Y, Shibata Y, Nagatsu A, Sakakibara J, Oomoto Y, Hirose K, Onozaki K
    International immunopharmacology 3(2) 273-277 Feb. 2003
  • IL-12 overexpression in mice as a model for Sjögren lung disease.
    McGrath-Morrow S, Laube B, Tzou SC, Cho C, Cleary J, Kimura H, Rose NR, Caturegli P
    American journal of physiology. Lung cellular and molecular physiology 291(4) L837-46 Oct. 2006
  • Interleukin (IL)-12-driven primary hypothyroidism: the contrasting roles of two Th1 cytokines (IL-12 and interferon-gamma).
    Kimura H, Tzou SC, Rocchi R, Kimura M, Suzuki K, Parlow AF, Rose NR, Caturegli P
    Endocrinology 146(8) 3642-3651 Aug. 2005
  • Increased thyroidal fat and goitrous hypothyroidism induced by interferon-gamma.
    Kimura H, Kimura M, Westra WH, Rose NR, Caturegli P
    International journal of experimental pathology 86(2) 97-106 Apr. 2005
  • Expression of class II major histocompatibility complex molecules on thyrocytes does not cause spontaneous thyroiditis but mildly increases its severity after immunization.
    Kimura H, Kimura M, Tzou SC, Chen YC, Suzuki K, Rose NR, Caturegli P
    Endocrinology 146(3) 1154-1162 Mar. 2005
  • Early chemokine expression induced by interferon-gamma in a murine model of Hashimoto's thyroiditis.
    Kimura H, Kimura M, Rose NR, Caturegli P
    Experimental and molecular pathology 77(3) 161-167 Dec. 2004
  • Studies on murine thyroiditis: new insights from organ flow cytometry.
    Caturegli P, Rose NR, Kimura M, Kimura H, Tzou SC
    Thyroid : official journal of the American Thyroid Association 13(5) 419-426 May 2003
  • Mycobacterium leprae infection in monocyte-derived dendritic cells and its influence on antigen-presenting function.
    Hashimoto K, Maeda Y, Kimura H, Suzuki K, Masuda A, Matsuoka M, Makino M
    Infection and immunity 70(9) 5167-5176 Sep. 2002

Prize

  • Jul. 2008 ATA grants 2008, American Thyroid Association
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Prizeclose
  • Jul. 2008 ATA grants 2008, American Thyroid Association


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