KUME Akihiro 

Faculty
Job titleProfessorWeb site

Profile

Research Keywords

    Gene Therapy, Regulatory Science

Research Areas

  • Biological science / Molecular biology
  • Biological science / Cell biology
  • Clinical internal medicine / Hematology
  • Clinical internal medicine / Pediatrics

Career

  • 2014
    -
    2016
    PMDA Office of Tissue and Cell-based Products, Principal Reviewer
  • 1992
    -
    1994
    Indiana University, Post-doctoral Fellow
  • 1994
    -
    1996
    Kumamoto University, Research Assistant
  • 1996
    -
    2000
    Jichi medical School, Lecturer
  • 2001
    - Jichi medical School, Assistant Professor
  • 2016
    -
    Today
    Juchi Medical University, Professor

Academic Background

  • -
    1990
    Graduate School, Division of Medicine, Tohoku University (japan)

Research Activities

Papers(paper)

  • Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno-associated virus vector
    KUME Akihiro
    Journal of Gene Medicine 13(2) 114-121 Feb. 2011
  • Muramatsu S, Fujimoto K, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I: A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson’s disease
    KUME Akihiro
    Molecular Therapy 18(9) 1081-1086 Sep. 2010
  • Long-term tracking of murine hematopoietic cells transduced with a bicistronic retrovirus containing CD24 and EGFP genes
    KUME Akihiro
    Gene Therapy 7(14) 1193-1199 Jul. 2000
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Papers(paper)close
  • Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno-associated virus vector
    KUME Akihiro
    Journal of Gene Medicine 13(2) 114-121 Feb. 2011
  • Muramatsu S, Fujimoto K, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I: A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson’s disease
    KUME Akihiro
    Molecular Therapy 18(9) 1081-1086 Sep. 2010
  • Long-term tracking of murine hematopoietic cells transduced with a bicistronic retrovirus containing CD24 and EGFP genes
    KUME Akihiro
    Gene Therapy 7(14) 1193-1199 Jul. 2000

Papers(other)

  • The Impaired Expression of Glycine Decarboxylase in Patients with Hyperglycinemias(共著)
    Biochemical and Biophysical Research Communications 154(1) 292-297 1988
  • One of the Two Genomic Copies of the Glycine Decarboxylase cDNA Has Been Deleted at a 5' Region in a Patient with Nonketotic Hyperglycemia(共著)
    Biochemical and Biophysical Research Communications 173(3) 801-806 1990
  • Genomic Analysis of Nonketotic Hyperglycinemia : A Partial Deletion of P-protein Gene(共著)
    Journal of Inherited Metabolic Disease 13(5) 766 1991
  • The Glycine Cleavage System : Molecular Cloning of the Chicken and Human Glycine Decarboxylase cDNAs and Some Characteristics Involved in the Deduced Protein Structures(共著)
    The Journal of Biological Chemistry 266(5) 3323 1991
  • The Glycine Cleavage System : the Coupled Expression of the Glycine Decarboxylase Gene and the H-protein Gene in the Chicken(共著)
    The Journal of Biological Chemistry 266(5) 3330 1991
  • Non-Ketotic Hyperglycinemia : A Life-threatening Disorder in Neonate(共著)
    Early Human Development 29(1) 75 1992
  • Retrovirus-mediated Reconstitution of Respiratory Burst Activity in X-linked Chronic Granulomatous Disease Cells(共著)
    Blood 84(10) 3311 1994
  • High level reconstitution of respiratory burst activity in human X-linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91phox (共著)
    Blood 88(5) 1834-1840
  • Focal adhesion kinase upregulated by granulocyte-macrophage colony-stimulating factor but not by interleukin-3 in differentiating myeloid cells. (共著)
    Blood 89(9) 3434-3442 1997
  • Apoptosis - mediated regulation of recoarbinant human granulocyte colony - Stimulating factor production by genetically engineered fibroblasts. (共著)
    Gene Therapy 5(7) 923-929 1998
Display all
Papers(other)close
  • The Impaired Expression of Glycine Decarboxylase in Patients with Hyperglycinemias(共著)
    Biochemical and Biophysical Research Communications 154(1) 292-297 1988
  • One of the Two Genomic Copies of the Glycine Decarboxylase cDNA Has Been Deleted at a 5' Region in a Patient with Nonketotic Hyperglycemia(共著)
    Biochemical and Biophysical Research Communications 173(3) 801-806 1990
  • Genomic Analysis of Nonketotic Hyperglycinemia : A Partial Deletion of P-protein Gene(共著)
    Journal of Inherited Metabolic Disease 13(5) 766 1991
  • The Glycine Cleavage System : Molecular Cloning of the Chicken and Human Glycine Decarboxylase cDNAs and Some Characteristics Involved in the Deduced Protein Structures(共著)
    The Journal of Biological Chemistry 266(5) 3323 1991
  • The Glycine Cleavage System : the Coupled Expression of the Glycine Decarboxylase Gene and the H-protein Gene in the Chicken(共著)
    The Journal of Biological Chemistry 266(5) 3330 1991
  • Non-Ketotic Hyperglycinemia : A Life-threatening Disorder in Neonate(共著)
    Early Human Development 29(1) 75 1992
  • Retrovirus-mediated Reconstitution of Respiratory Burst Activity in X-linked Chronic Granulomatous Disease Cells(共著)
    Blood 84(10) 3311 1994
  • High level reconstitution of respiratory burst activity in human X-linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91phox (共著)
    Blood 88(5) 1834-1840
  • Focal adhesion kinase upregulated by granulocyte-macrophage colony-stimulating factor but not by interleukin-3 in differentiating myeloid cells. (共著)
    Blood 89(9) 3434-3442 1997
  • Apoptosis - mediated regulation of recoarbinant human granulocyte colony - Stimulating factor production by genetically engineered fibroblasts. (共著)
    Gene Therapy 5(7) 923-929 1998
  • Fas and mutant estrogen receptor chimeric gene : anovel suicide vector for tamoxifen - induced apoptosis. (共著)
    Japanese Journal of Cancer Research 89(7) 741-747 1998
  • Develpment of a modified selective amplifier gene for hematopoietic stem cell gene therapy(共著)
    Gene Therapy 6(6) 1038-1044 1999
  • A G-CSF receptor-gyrase B fusion gene : a new type of molecu lar Switch for expansion of genetically modified hematopoietic cell, (共著)
    Biochemical and Biophysical Research Communications 260(1) 9-12 1999
  • Green fluorescent protein as a sele ctable marker of retroairally transduced hematopoietic progenitors(共著)
    Stem Cells 17(4) 226-232
  • A selective amplifier gene for tamoxifen-induced expansion of hematopoietic cells(共著)
    Journal of Gene Medicine 1(4) 236-244 1999
  • Hematopoietic stem cell gene therapy : a current overview(共著)
    International Journal of Hematology 69(4) 227-233 1999
  • Gene theapy for chronic granulomafous disease(共著)
    Journal of Clinical and Laboratory Medicine 135(2) 122-128 2000
  • Long-term tracking of murine hemutopoietic cells with a bicistronic retrovirus containing CD24 and EGFP genes.(共著)
    Gene Therapy 7(14) 1193-1199 2000
  • Triple transduction with adeno-associated vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase (]G0001[) for gene therapy of Parkinson's disease.(共著)
    Human Gene Therapy 11(11) 1509-1519 2000
  • Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatul cells with adenoassociated viral vectors expressing dopamine-synthethizing enzymes(共著)
    Human Gene Therapy 13(3) 345 2002
  • In vivo selective exparsion of gene-modified hemutopoietic in a nonhuman primate model(共著)
    Gene Therapy 9(16) 1055 2002
  • Selective growth advantage of wild-type lymphoytes in X-SCID recipients(共著)
    Bone Warrow Transplantion 30(2) 113 2002
  • In vivo expansion of transduced murine hematopoietic cells with a selective amplifier gene
    Journal of Gene Medicine 5(3) 175 2003
  • Reduction of CTLL-2 Cytotoxicity by Inducible Apoptosis with a Fas-estrogen Receptor Chimera
    Cancer Science 94(7) 639-643 2003
  • Long-term correction of hyperphenylalaninemia by AAV-mediated gene transfer leads to behavioral recovery in phenylketonuria mice
    Gene Therapy 11(13) 1081-1086 2004
  • Expansion of genetically corrected neutrophils in chronic granulomatous disease mice by cotransferring a therapeutic gene and a selective amplifier gene
    Gene Therapy 11(18) 1370-1377 2004
  • High-level in vivo gene marking after gene-modified autologous hematopoietic stem cell transplantation without marrow conditioning in nonhuman primates
    Molecular Therapy 10(3) 469-477 2004

Book

  • CD34 Workshop : Cross - linking of CD34 on hematopoietic cells induces homotypic cell adhesion via clustering of CD34 and mobilization of adhesion molecules. (共著)
    Lenkocyte Typing VI , Garland Puhilishing Inc . , New York and London 1997
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Bookclose
  • CD34 Workshop : Cross - linking of CD34 on hematopoietic cells induces homotypic cell adhesion via clustering of CD34 and mobilization of adhesion molecules. (共著)
    Lenkocyte Typing VI , Garland Puhilishing Inc . , New York and London 1997

Outside Fund Adoption

  • Proliferation and Differentiation of Hemutopoietic Stem cells
    :Grant-in-Aid for Scientific Research
    Project Year :1994 - 2023
  • Development of New Vectors for Gene Therapy
    :Grant-in-Aid for Scientific Research
    Project Year :1996 - 2023
  • Department of Gene Therapy Vectors
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Outside Fund Adoptionclose
  • Proliferation and Differentiation of Hemutopoietic Stem cells
    :Grant-in-Aid for Scientific Research
    Project Year :1994 - 2023
  • Development of New Vectors for Gene Therapy
    :Grant-in-Aid for Scientific Research
    Project Year :1996 - 2023
  • Department of Gene Therapy Vectors

Works

  • Selevtive Expansion of Gene Tically Modified Hemutopoietic stom cells
    1999-2000
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Worksclose
  • Selevtive Expansion of Gene Tically Modified Hemutopoietic stom cells
    1999-2000


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