KUME Akihiro 

Faculty
Job titleProfessorWeb site

Profile

Research Keywords

    Gene Therapy, Regulatory Science

Research Areas

  • Biological science / Molecular biology
  • Biological science / Cell biology
  • Clinical internal medicine / Hematology
  • Clinical internal medicine / Pediatrics

Career

  • 2014
    -
    2016
    PMDA Office of Tissue and Cell-based Products, Principal Reviewer
  • 1992
    -
    1994
    Indiana University, Post-doctoral Fellow
  • 1994
    -
    1996
    Kumamoto University, Research Assistant
  • 1996
    -
    2000
    Jichi medical School, Lecturer
  • 2001
    - Jichi medical School, Assistant Professor
  • 2016
    -
    Today
    Juchi Medical University, Professor

Academic Background

  • -
    1990
    Graduate School, Division of Medicine, Tohoku University (japan)

Research Activities

Papers(paper)

  • Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno-associated virus vector
    KUME Akihiro
    Journal of Gene Medicine 13(2) 114-122 Feb. 2011
  • Muramatsu S, Fujimoto K, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I: A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson’s disease
    KUME Akihiro
    Molecular Therapy 18(9) 1081-1086 Sep. 2010
  • Long-term tracking of murine hematopoietic cells transduced with a bicistronic retrovirus containing CD24 and EGFP genes
    KUME Akihiro
    Gene Therapy 7(14) 1193-1199 Jul. 2000
Display all
Papers(paper)close
  • Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno-associated virus vector
    KUME Akihiro
    Journal of Gene Medicine 13(2) 114-122 Feb. 2011
  • Muramatsu S, Fujimoto K, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I: A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson’s disease
    KUME Akihiro
    Molecular Therapy 18(9) 1081-1086 Sep. 2010
  • Long-term tracking of murine hematopoietic cells transduced with a bicistronic retrovirus containing CD24 and EGFP genes
    KUME Akihiro
    Gene Therapy 7(14) 1193-1199 Jul. 2000

Papers(other)

  • The Impaired Expression of Glycine Decarboxylase in Patients with Hyperglycinemias(共著)
    KUME A, KURE S, TADA K, HIRAGA K
    Biochemical and Biophysical Research Communications 154(1) 292-297 1988
  • One of the Two Genomic Copies of the Glycine Decarboxylase cDNA Has Been Deleted at a 5' Region in a Patient with Nonketotic Hyperglycemia(共著)
    SAKAKIBARA T, KOYATA H, ISHIGURO Y, KURE S, KUME A, TADA K, HIRAGA K
    Biochemical and Biophysical Research Communications 173(3) 801-806 1990
  • Genomic Analysis of Nonketotic Hyperglycinemia : A Partial Deletion of P-protein Gene(共著)
    Journal of Inherited Metabolic Disease 13(5) 766 1991
  • The Glycine Cleavage System : Molecular Cloning of the Chicken and Human Glycine Decarboxylase cDNAs and Some Characteristics Involved in the Deduced Protein Structures(共著)
    The Journal of Biological Chemistry 266(5) 3323 1991
  • The Glycine Cleavage System : the Coupled Expression of the Glycine Decarboxylase Gene and the H-protein Gene in the Chicken(共著)
    The Journal of Biological Chemistry 266(5) 3330 1991
  • Non-Ketotic Hyperglycinemia : A Life-threatening Disorder in Neonate(共著)
    Early Human Development 29(1) 75 1992
  • Retrovirus-mediated Reconstitution of Respiratory Burst Activity in X-linked Chronic Granulomatous Disease Cells(共著)
    Blood 84(10) 3311 1994
  • High level reconstitution of respiratory burst activity in human X-linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91phox (共著)
    Blood 88(5) 1834-1840
  • Focal adhesion kinase upregulated by granulocyte-macrophage colony-stimulating factor but not by interleukin-3 in differentiating myeloid cells. (共著)
    Blood 89(9) 3434-3442 1997
  • Apoptosis - mediated regulation of recoarbinant human granulocyte colony - Stimulating factor production by genetically engineered fibroblasts. (共著)
    Gene Therapy 5(7) 923-929 1998
Display all
Papers(other)close
  • The Impaired Expression of Glycine Decarboxylase in Patients with Hyperglycinemias(共著)
    KUME A, KURE S, TADA K, HIRAGA K
    Biochemical and Biophysical Research Communications 154(1) 292-297 1988
  • One of the Two Genomic Copies of the Glycine Decarboxylase cDNA Has Been Deleted at a 5' Region in a Patient with Nonketotic Hyperglycemia(共著)
    SAKAKIBARA T, KOYATA H, ISHIGURO Y, KURE S, KUME A, TADA K, HIRAGA K
    Biochemical and Biophysical Research Communications 173(3) 801-806 1990
  • Genomic Analysis of Nonketotic Hyperglycinemia : A Partial Deletion of P-protein Gene(共著)
    Journal of Inherited Metabolic Disease 13(5) 766 1991
  • The Glycine Cleavage System : Molecular Cloning of the Chicken and Human Glycine Decarboxylase cDNAs and Some Characteristics Involved in the Deduced Protein Structures(共著)
    The Journal of Biological Chemistry 266(5) 3323 1991
  • The Glycine Cleavage System : the Coupled Expression of the Glycine Decarboxylase Gene and the H-protein Gene in the Chicken(共著)
    The Journal of Biological Chemistry 266(5) 3330 1991
  • Non-Ketotic Hyperglycinemia : A Life-threatening Disorder in Neonate(共著)
    Early Human Development 29(1) 75 1992
  • Retrovirus-mediated Reconstitution of Respiratory Burst Activity in X-linked Chronic Granulomatous Disease Cells(共著)
    Blood 84(10) 3311 1994
  • High level reconstitution of respiratory burst activity in human X-linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91phox (共著)
    Blood 88(5) 1834-1840
  • Focal adhesion kinase upregulated by granulocyte-macrophage colony-stimulating factor but not by interleukin-3 in differentiating myeloid cells. (共著)
    Blood 89(9) 3434-3442 1997
  • Apoptosis - mediated regulation of recoarbinant human granulocyte colony - Stimulating factor production by genetically engineered fibroblasts. (共著)
    Gene Therapy 5(7) 923-929 1998
  • Fas and mutant estrogen receptor chimeric gene : anovel suicide vector for tamoxifen - induced apoptosis. (共著)
    Japanese Journal of Cancer Research 89(7) 741-747 1998
  • Develpment of a modified selective amplifier gene for hematopoietic stem cell gene therapy(共著)
    MATSUDA Km, KUME A, UEDA Y, URABE M, HASEGAWA M, OZAWA K
    Gene Therapy 6(6) 1038-1044 1999
  • A G-CSF receptor-gyrase B fusion gene : a new type of molecu lar Switch for expansion of genetically modified hematopoietic cell, (共著)
    KUME A, ITO K, UEDA Y, HASEGAWA M, URABE M, MANO H, OZAWA K
    Biochemical and Biophysical Research Communications 260(1) 9-12 1999
  • Green fluorescent protein as a sele ctable marker of retroairally transduced hematopoietic progenitors(共著)
    Stem Cells 17(4) 226-232
  • A selective amplifier gene for tamoxifen-induced expansion of hematopoietic cells(共著)
    Journal of Gene Medicine 1(4) 236-244 1999
  • Hematopoietic stem cell gene therapy : a current overview(共著)
    International Journal of Hematology 69(4) 227-233 1999
  • Gene theapy for chronic granulomafous disease(共著)
    Journal of Clinical and Laboratory Medicine 135(2) 122-128 2000
  • Long-term tracking of murine hemutopoietic cells with a bicistronic retrovirus containing CD24 and EGFP genes.(共著)
    Gene Therapy 7(14) 1193-1199 2000
  • Triple transduction with adeno-associated vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase (]G0001[) for gene therapy of Parkinson's disease.(共著)
    SHEN Y, MURAMATSU Si, IKEGUCHI K, FUJIMOTO Ki, FAN Ds, OGAWA M, MIZUKAMI H, URABE M, KUME A, NAGATSU I, URANO F, SUZUKI T, ICHINOSE H, NAGATSU T, MONAHAN J, NAKANO I, OZAWA K
    Human Gene Therapy 11(11) 1509-1519 2000
  • Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatul cells with adenoassociated viral vectors expressing dopamine-synthethizing enzymes(共著)
    MURAMATSU Si, FUJIMOTO Ki, IKEGUCHI K, SHIZUMA N, KAWASAKI K, ONO F, SHEN Y, WANG Lj, MIZUKAMI H, KUME A, MATSUMURA M, NAGATSU I, URANO F, ICHINOSE H, NAGATSU T, TERAO K, NAKANO I, OZAWA K
    Human Gene Therapy 13(3) 345-354 2002
  • In vivo selective exparsion of gene-modified hemutopoietic in a nonhuman primate model(共著)
    HANAZONO Y, NAGASHIMA T, TAKATOKU M, SHIBATA H, AGEYAMA N, ASANO T, UEDA Y, DUNBAR Ce, KUME A, TERAO K, HASEGAWA M, OZAWA K
    Gene Therapy 9(16) 1055-1064 2002
  • Selective growth advantage of wild-type lymphoytes in X-SCID recipients(共著)
    KUME A, KOREMOTO M, MIZUKAMI H, OKADA T, HANAZONO Y, SUGAMURA K, OZAWA K
    Bone Warrow Transplantion 30(2) 113-118 2002
  • In vivo expansion of transduced murine hematopoietic cells with a selective amplifier gene
    KUME A, KOREMOTO M, XU Rf, OKADA T, MIZUKAMI H, HANAZONO Y, HASEGAWA M, OZAWA K
    Journal of Gene Medicine 5(3) 175-181 2003
  • Reduction of CTLL-2 Cytotoxicity by Inducible Apoptosis with a Fas-estrogen Receptor Chimera
    KAMETAKA M, KUME A, OKADA T, MIZUKAMI H, HANAZONO Y, OZAWA K
    Cancer Science 94(7) 639-643 2003
  • Long-term correction of hyperphenylalaninemia by AAV-mediated gene transfer leads to behavioral recovery in phenylketonuria mice
    MOCHIZUKI S, MIZUKAMI H, OGURA T, KURE S, ICHINOHE A, KOJIMA K, MATSUBARA Y, KOBAYAHI E, OKADA T, HOSHIKA A, OZAWA K, KUME A
    Gene Therapy 11(13) 1081-1086 2004
  • Expansion of genetically corrected neutrophils in chronic granulomatous disease mice by cotransferring a therapeutic gene and a selective amplifier gene
    HARA T, KUME A, HANAZONO Y, MIZUKAMI H, OKADA T, TSURUMI H, MORIWAKI H, UEDA Y, HASEGAWA M, OZAWA K
    Gene Therapy 11(18) 1370-1377 2004
  • High-level in vivo gene marking after gene-modified autologous hematopoietic stem cell transplantation without marrow conditioning in nonhuman primates
    UEDA K, HANAZONO Y, SHIBATA H, AGEYAMA N, UEDA Y, OGATA S, TABATA T, NAGASHIMA T, TAKATOKU M, KUME A, IKEHARA S, TANIWAKI M, TERAO K, HASEGAWA M, OZAWA K
    Molecular Therapy 10(3) 469-477 2004

Book

  • CD34 Workshop : Cross - linking of CD34 on hematopoietic cells induces homotypic cell adhesion via clustering of CD34 and mobilization of adhesion molecules. (共著)
    Lenkocyte Typing VI , Garland Puhilishing Inc . , New York and London 1997
Display all
Bookclose
  • CD34 Workshop : Cross - linking of CD34 on hematopoietic cells induces homotypic cell adhesion via clustering of CD34 and mobilization of adhesion molecules. (共著)
    Lenkocyte Typing VI , Garland Puhilishing Inc . , New York and London 1997

Outside Fund Adoption

  • Proliferation and Differentiation of Hemutopoietic Stem cells
    :Grant-in-Aid for Scientific Research
    Project Year :1994 - 2023
  • Development of New Vectors for Gene Therapy
    :Grant-in-Aid for Scientific Research
    Project Year :1996 - 2023
  • Department of Gene Therapy Vectors
Display all
Outside Fund Adoptionclose
  • Proliferation and Differentiation of Hemutopoietic Stem cells
    :Grant-in-Aid for Scientific Research
    Project Year :1994 - 2023
  • Development of New Vectors for Gene Therapy
    :Grant-in-Aid for Scientific Research
    Project Year :1996 - 2023
  • Department of Gene Therapy Vectors

Works

  • Selevtive Expansion of Gene Tically Modified Hemutopoietic stom cells
    1999-2000
Display all
Worksclose
  • Selevtive Expansion of Gene Tically Modified Hemutopoietic stom cells
    1999-2000


Copyright c MEDIA FUSION Co.,Ltd. All rights reserved.