Researchers Database

noguchi tadahide

    DentistryandOralSurgery Professor
Contact: noguchitjichi.ac.jp
Last Updated :2021/11/23

Researcher Information

Degree

  • (BLANK)(Jichi Medical University)

J-Global ID

Research Interests

  • 外科系歯学   

Research Areas

  • Life sciences / Surgical dentistry

Education

  •        - 1990  Health Sciences University of Hokkaido  School of Dentistry

Association Memberships

  • 日本頭頚部腫瘍学会   日本口腔科学会   日本口腔外科学会   日本口腔診断学会   日本口腔内科学会   日本顎変形症学会   日本口蓋裂学会   日本口腔腫瘍学会   

Published Papers

  • Ota Y, Noguchi T, Ariji E, Fushimi C, Fuwa N, Harada H, Hayashi T, Hayashi R, Honma Y, Miura M, Mori T, Nagatsuka H, Okura M, Ueda M, Uzawa N, Yagihara K, Yagishita H, Yamashiro M, Yanamoto S, Kirita T
    International Journal of Clinical Oncology 26 (4) 623 - 635 2021 [Refereed]
     
    For doctors and other medical staff treating oral cancer, it is necessary to standardize the basic concepts and rules for oral cancer to achieve progress in its treatment, research, and diagnosis. Oral cancer is an integral part of head and neck cancer and is treated in accordance with the general rules for head and neck cancer. However, detailed rules based on the specific characteristics of oral cancer are essential. The objective of this article was to contribute to the development of the diagnosis, treatment, and research of oral cancer, based on the correct and useful medical information of clinical, surgical, pathological, and imaging findings accumulated from individual patients at various institutions. Our general rules were revised as the UICC was revised for the 8th edition and were published as the Japanese second edition in 2019. In this paper, the English edition of the "Rules" section is primarily presented.
  • 舌・口底癌における遊離皮弁再建術後の口腔皮膚瘻についての検討
    杉浦 康史, 野口 忠秀, 土肥 昭博, 早坂 純一, 去川 俊二, 森 良之
    頭頸部癌 (一社)日本頭頸部癌学会 46 (2) 210 - 210 1349-5747 2020/07
  • 層板骨を用いた顎裂部骨移植術後の骨形態に関する評価
    田村 知子, 野口 忠秀, 今野 悠, 七條 なつ子, 仁保 千秋, 笹栗 健一, 須永 中, 森 良之
    日本口蓋裂学会雑誌 (一社)日本口蓋裂学会 45 (2) 184 - 184 0386-5185 2020/05
  • 田中 理紗子, 岡田 成生, 七條 なつ子, 野口 忠秀, 笹栗 健一, 森 良之
    栃木県歯科医学会誌 (一社)栃木県歯科医師会 72 13 - 15 2020/04 
    Le Fort I型骨切り術(LI)単独と馬蹄形+LIを比較し、馬蹄形+LIによる上下顎移動術の有用性について検討した。当院で施行した上下顎移動術22症例のうち、馬蹄形+LI 4症例を対象とした。出血量については、馬蹄形+LIは約635mL、LIは約379mLとなり、馬蹄形+LIとLIの出血量には有意差が認められた。手術時間は馬蹄形+LIは約5時間24分、LIは約5時間2分であり、馬蹄形+LIとLIの手術時間には有意差は認められなかった。馬蹄形の予定上顎移動量と実際の上顎移動量の比較については、前方部の予定移動量は3.75mm、実際の上顎移動量は3.3mm、後方部の予定移動量は4.25mm、実際の上顎移動量は2.8mmとなった。後方部の実際の上顎移動量が予定の上顎移動量より少なくなった理由として、後方部は蝶形骨翼状突起をはじめ下行口蓋動脈周囲の骨の干渉が完全に取り除けていなかったことなどが考えられた。
  • 当科で行っている口腔癌症例におけるモールド照射の工夫
    白石 晃平, 野口 忠秀, 今野 悠, 杉浦 康史, 土肥 昭博, 作山 葵, 神部 芳則, 森 良之
    栃木県歯科医学会誌 (一社)栃木県歯科医師会 72 9 - 12 2020/04
  • 頭頸部癌化学放射線療法を行っている患者に対するがん支持療法の重要性
    若林 宣江, 戸田 浩司, 鈴木 祐子, 山川 道代, 杉浦 康史, 土肥 昭博, 岡田 成生, 野口 忠秀, 神部 芳則, 森 良之
    日本口腔診断学会雑誌 (一社)日本口腔診断学会 33 (1) 83 - 84 0914-9694 2020/02
  • 本態性血小板血症患者に対する下顎骨関節突起骨折の治療経験
    大谷津 幸生, 串田 淳子, 杉浦 康史, 田村 知子, 仙名 あかね, 渡邊 秀紀, 岡田 成生, 野口 忠秀, 神部 芳則, 森 良之
    日本口腔診断学会雑誌 (一社)日本口腔診断学会 33 (1) 103 - 103 0914-9694 2020/02
  • 造血幹細胞移植後の慢性GVHD患者に生じた舌扁平上皮癌の1例
    作山 葵, 早坂 純一, 杉浦 康史, 岡田 成生, 野口 忠秀, 神部 芳則, 森 良之
    日本口腔診断学会雑誌 (一社)日本口腔診断学会 33 (1) 134 - 135 0914-9694 2020/02
  • Combination laser treatment with real-time ultrasound navigation for oral venous malformations.
    Noguchi T, Konno Y, Sugiura Y, Dohi A, Okada N, Sasaguri K, Oyatsu Y, Fujita A, Miyazaki H, Mori Y
    Journal of Craniofacial Surgery 31 (8) 1 - 7 2020 [Refereed]
  • 頭頸部癌化学放射線療法を行っている患者に対するがん支持療法の重要性
    若林 宣江, 戸田 浩司, 鈴木 祐子, 山川 道代, 杉浦 康史, 土肥 昭博, 岡田 成生, 野口 忠秀, 神部 芳則, 森 良之
    日本口腔内科学会雑誌 (一社)日本口腔内科学会 25 (2) 73 - 74 2186-6147 2019/12
  • 生体腎移植後の免疫抑制剤内服患者に発症した下顎骨骨髄炎の1例
    岡田 成生, 長島 優太, 杉浦 康史, 土肥 昭博, 野口 忠秀, 神部 芳則, 森 良之
    日本口腔内科学会雑誌 (一社)日本口腔内科学会 25 (2) 92 - 92 2186-6147 2019/12
  • 本態性血小板血症患者に対する下顎骨関節突起骨折の治療経験
    大谷津 幸生, 串田 淳子, 杉浦 康史, 田村 知子, 仙名 あかね, 渡邊 秀紀, 岡田 成生, 野口 忠秀, 神部 芳則, 森 良之
    日本口腔内科学会雑誌 (一社)日本口腔内科学会 25 (2) 93 - 93 2186-6147 2019/12
  • 造血幹細胞移植後の慢性GVHD患者に生じた舌扁平上皮癌の1例
    作山 葵, 早坂 純一, 杉浦 康史, 岡田 成生, 野口 忠秀, 神部 芳則, 森 良之
    日本口腔内科学会雑誌 (一社)日本口腔内科学会 25 (2) 124 - 125 2186-6147 2019/12
  • 頬部蜂窩織炎を契機に糖尿病性ケトアシドーシスを来した未治療糖尿病の1例
    加藤 圭一郎, 早坂 純一, 中村 知寿, 長島 優太, 仁保 千秋, 杉浦 康史, 作山 葵, 岡田 成生, 野口 忠秀, 神部 芳則, 森 良之
    栃木県歯科医学会誌 (一社)栃木県歯科医師会 71 27 - 31 2019/04 
    症例は31歳男性で、左頬部腫脹および疼痛が出現し、アジスロマイシン、ロキソプロフェンナトリウムの投与を受けるも改善せず、当院紹介受診となった。検査結果より上顎左67根尖病巣を起因とする左側頬部蜂窩織炎と診断し、セフトリアキソンナトリウムの投与と切開排膿処置による消炎治療を開始した。第1病日より全身倦怠感、腹痛、嘔吐が著明となり再度問診したところ、数週間前から1日2000mlの清涼飲料水を飲用していたことが明らかになり、さらに、5ヵ月前から20kgの体重減少を生じていたことが判明した。糖尿病性ケトアシドーシスの診断を得て内分泌代謝科に転科し、食止となり持続インスリン療法が開始され、第3病日に全身状態が改善した。第16病日には経口血糖降下剤に移行され、第17病日には原因歯である上顎左678の抜歯を行った。その後も血糖値は良好にコントロールされ、歯性感染症の再燃なく第22病日に退院となった。
  • Tadahide Noguchi, Yasushi Sugiura, Naruo Okada, Yoshiyuki Tsuchiya, Jun-Ichi Hyasaka, Ken-Ichi Sasaguri, Shunji Sarukawa, Akifumi Fujita, Yusuke Amano, Yoshiyuki Mori
    Journal of medical case reports 13 (1) 58 - 58 2019/03 [Refereed][Not invited]
     
    BACKGROUND: Osteosarcomas of the head and neck region are rare entities that comprise < 10% of all osteosarcomas. Multimodality treatment of patients with osteosarcoma is well-established for osteosarcoma in long bones, and the benefits of chemotherapy in long bones are clearly known. However, there is no consensus regarding the effects of chemotherapy in cases of head and neck osteosarcoma. The prognostic factor for head and neck osteosarcoma is complete tumor resection with negative margin, which is a radical surgery. However, a clear margin may be difficult to achieve in the head and neck region. CASE PRESENTATION: We present a case of a 69-year-old Japanese woman who developed osteosarcoma of the condyle within the masticator space and infratemporal fossa, which was treated with radical surgery using a modified preauricular and transmandibular approach. Although we recommended adjuvant treatment after surgery, the patient refused this treatment. There was no evidence of local recurrence or distant metastasis through 30 months of follow-up. CONCLUSIONS: Our modified preauricular and transmandibular approach allowed access to the masticator space and infratemporal fossa, thereby increasing complete resection of the tumor and resulting in minimal functional and cosmetic deficits.
  • Mitsunobu Otsuru, Yoshihide Ota, Souichi Yanamoto, Masaya Okura, Masahiro Umeda, Tadaaki Kirita, Hiroshi Kurita, Michihiro Ueda, Takahide Komori, Nobuhiro Yamakawa, Takahiro Kamata, Takumi Hasegawa, Takahiko Shibahara, Youichi Ohiro, Yoshihiro Yamashita, Kazuma Noguchi, Tadahide Noguchi, Kazunari Karakida, Hiroyuki Naito, Tomonao Aikawa, Tetsuro Yamashita, Daijiro Kabata, Ayumi Shintani
    Annals of surgical oncology 26 (2) 555 - 563 2019/02 [Refereed][Not invited]
     
    BACKGROUND: This multicenter retrospective study aimed to determine whether elective neck dissection (END) can be performed for T1-2N0M0 tongue cancer. METHODS: Patients with T1-2N0M0 tongue squamous cell carcinoma who received treatment between January 2000 and December 2012 were enrolled at 14 multicenter study sites. The 5-year overall survival (OS) and 5-year disease-specific survival (DSS) were compared between the propensity score-matched END and observation (OBS) groups. RESULTS: The results showed that the OS rates among the 1234 enrolled patients were 85.5% in the END group and 90.2% in the OBS group (P = 0.182). The DSS rates were 87.0% in the END group and 94.3% in the OBS group (P = 0.003). Among the matched patients, the OS rates were 87.1% in the END group and 76.2% in the OBS group (P = 0.0051), and the respective DSS rates were 89.2% and 82.2% (P = 0.0335). CONCLUSION: This study showed that END is beneficial for T1-2N0M0 tongue cancer. However, END should be performed for patients with a tumor depth of 4-5 mm or more, which is the depth associated with a high rate of lymph node metastasis. The use of END should be carefully considered for both elderly and young patients.
  • 口唇、口腔粘膜に広範囲に潰瘍を生じ長期間にわたり口腔衛生管理を行った1例
    安野 ななほ, 若林 宣江, 鈴木 祐子, 井上 千恵子, 中村 知寿, 岡田 成生, 野口 忠秀, 神部 芳則, 森 良之
    日本口腔内科学会雑誌 (一社)日本口腔内科学会 24 (2) 91 - 92 2186-6147 2018/12
  • Y. Sugiura, S. Sarukawa, J. Hayasaka, H. Kamochi, T. Noguchi, Y. Mori
    International Journal of Oral and Maxillofacial Surgery 47 (8) 983 - 989 1399-0020 2018/08 [Refereed][Not invited]
     
    The purpose of this study was to evaluate surgical outcomes in elderly patients who had undergone free fibula flap transfer for malignant head and neck tumours. A retrospective chart review was performed to identify patients who had undergone free fibula flap transfer for mandibular reconstruction after malignant tumour resection at Jichi Medical University Hospital between May 2009 and April 2015. Enrolled patients were divided into an elderly group (≥80 years old) and a younger group (< 80 years old). Seventeen patients met the inclusion criteria and were included in the elderly group. Age at surgery ranged from 80 to 92 years. Thirteen patients (76.5%) experienced postoperative complications. Surgical site complications occurred in seven patients. The success rate of free fibula flap transfer was 100%. Systemic complications occurred in nine patients, most commonly delirium (n = 6). No perioperative mortality was encountered. The overall 1-year survival rate was 94.1% (16/17). No patient reported gait disturbance as a donor site complication or any other major complication. The incidence of postoperative complications did not differ significantly between the elderly and younger groups. Almost no difference in postoperative course was seen between the groups. Elderly patients appear to tolerate free fibula flap reconstruction just as well as younger patients.
  • T Noguchi, S Sarukawa, Y Tsuchiya, N Okada, J Hayasaka, K Sasaguri, H Nishino, Y Jinbu, Y Mori
    International journal of oral and maxillofacial surgery 47 (8) 990 - 997 2018/08 [Refereed][Not invited]
     
    Vascularized iliac bone grafts are used for mandibular reconstruction, but the factors affecting graft maintenance are unknown. This study explored the postsurgical changes in vascularized iliac bone grafts in patients who had undergone mandibular reconstruction after segmental resection. The study involved 24 patients (16 men and eight women) with oral tumours or osteoradionecrosis. Thirteen patients required bare bone grafting (BBG) and 11 patients required reconstruction with soft tissue coverage (six with a skin paddle and five with direct closure). The bone graft maintenance rate (with regard to the height of the centre of the graft) was calculated immediately after surgery and at 3, 6, 12, 24, and 36months after surgery. The maintenance rate was significantly lower in the BBG group than in the soft tissue coverage group at 3, 6, 12, 24, and 36months, and in those who were fitted with dentures compared to those who were not at 6, 12, 24, and 36months. Local infection also influenced the maintenance rate, but not significantly so. These findings indicate that the reconstruction technique and denture use can affect the bone graft maintenance rate after mandibular reconstruction with vascularized iliac bone grafts.
  • 広範囲顎顔面再建による社会復帰への挑戦 重粒子線照射後の広範な頬部軟組織欠損および放射線性下顎骨壊死に対する再建
    早坂 純一, 去川 俊二, 林 宏栄, 杉浦 康史, 山川 道代, 作山 葵, 伊藤 弘人, 野口 忠秀, 神部 芳則, 勝又 敏明, 森 良之
    日本口腔科学会雑誌 (NPO)日本口腔科学会 67 (2) 197 - 197 0029-0297 2018/07
  • 頬粘膜に発生した4重複癌の1例
    岩上 藍, 早坂 純一, 中村 知寿, 林 宏栄, 山川 道代, 作山 葵, 岡田 成生, 野口 忠秀, 神部 芳則, 森 良之
    日本口腔科学会雑誌 (NPO)日本口腔科学会 67 (2) 182 - 182 0029-0297 2018/07
  • Hidetaka Miyazaki, Takafumi Ohshiro, Umberto Romeo, Tadahide Noguchi, Yutaka Maruoka, Gianfranco Gaimari, Georgi Tomov, Yoshitaka Wada, Kae Tanaka, Toshio Ohshiro, Shinichi Asamura
    Photomedicine and Laser Surgery 36 (6) 320 - 325 1549-5418 2018/06 [Refereed][Not invited]
     
    Objective: This study aimed to retrospectively evaluate the efficacy and safety of laser treatment of oral vascular lesions using the multiple spot irradiation technique with a single-pulsed wave. Background data: In laser therapy for vascular lesions, heat accumulation induced by excessive irradiation can cause adverse events postoperatively, including ulcer formation, resultant scarring, and severe pain. To prevent heat accumulation and side effects, we have applied a multiple pulsed spot irradiation technique, the so-called "leopard technique" (LT) to oral vascular lesions. This approach was originally proposed for laser treatment of nevi. It can avoid thermal concentration at the same spot and spare the epithelium, which promotes smooth healing. The goal of the study was to evaluate this procedure and treatment outcomes. Patients and methods: The subjects were 46 patients with 47 oral vascular lesions treated with the LT using a Nd:YAG laser (1064 nm), including 24 thick lesions treated using a combination of the LT and intralesional photocoagulation. Results: All treatment outcomes were satisfactory without serious complications such as deep ulcer formation, scarring, bleeding, or severe swelling. Conclusions: Laser therapy with the LT is a promising less-invasive treatment for oral vascular lesions.
  • 頭頸部癌に対する低侵襲・機能温存手術 今後の展望 可動部舌切除再建における侵襲と術後機能
    去川 俊二, 杉浦 康史, 野口 忠秀, 森 良之, 西野 宏
    頭頸部癌 (一社)日本頭頸部癌学会 44 (2) 104 - 104 1349-5747 2018/05
  • プレート軟組織皮弁による下顎再建後二次的骨移植の検討
    杉浦 康史, 去川 俊二, 早坂 純一, 林 宏栄, 作山 葵, 岡田 成生, 野口 忠秀, 神部 芳則, 西野 宏, 森 良之
    頭頸部癌 (一社)日本頭頸部癌学会 44 (2) 227 - 227 1349-5747 2018/05
  • Yoshiyuki Tsuchiya, Kentaro Ushijima, Tadahide Noguchi, Naruo Okada, Jun-ichi Hayasaka, Yoshinori Jinbu, Hitoshi Ando, Yoshiyuki Mori, Mikio Kusama, Akio Fujimura
    Chronobiology International 35 (2) 289 - 294 1525-6073 2018/02 [Refereed][Not invited]
     
    Docetaxel, cisplatin plus fluorouracil (DCF) regimen is a useful chemotherapy, but is sometimes withdrawn due to severe adverse effects (AE). In this study, we examined whether the chronotherapy of DCF regimen could reduce the drugs-induced toxicities in clinical practice. Patients with oral squamous cell carcinoma were enrolled. Chemotherapy started at 10:30 (Morning-dosing) or 18:30 (Evening-dosing) for 5 days by a cross-over design. AE were assessed for 14 days after an initiation of each dosing. The grades of nausea, vomiting and neutropenia were smaller during Evening-dosing than during Morning-dosing. These data suggest that the chrono-chemotherapy might provide a merit for reducing the DCF regimen-related severe AE.
  • Hiromi Otawara, Yoshinori Jinbu, Yasuhisa Shinozaki, Hiroto Ito, Tadahide Noguchi, Natsuki Segami, Kaoru Kobayashi, Naoyuki Matsumoto, Yoshiyuki Mori
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 30 (1) 39 - 43 2212-5558 2018/01 [Refereed][Not invited]
     
    Ganglion cysts frequently occur on the dorsal side of the carpal joints, but rarely involve the temporomandibular joint. We encountered a 64-year-old woman with a chief complaint of swelling in the right cheek. Lipoma was observed in the right cheek on magnetic resonance imaging, along with a cystic lesion in the left temporomandibular joint. The cyst in the left temporomandibular joint was extracted under general anesthesia. Histological diagnosis was ganglion cyst. We report our experience with a case of ganglion cysts occurring on the temporomandibular joint with reference to the literature.
  • Tadahide Noguchi, Naruo Okada, Yoshiyuki Tsuchiya, Shunji Sarukawa, Akifumi Fujita, Hiroshi Nishino, Yoshinori Jinbu, Yoshiyuki Mori
    Journal of Craniofacial Surgery 29 (1) e18 - e20 1536-3732 2018/01 [Refereed][Not invited]
     
    In this clinical report, we present the management of a brain abscess that was presumed to be caused by radiation osteomyelitis of the mandible. The patient underwent chemoradiotherapy for oropharyngeal carcinoma on the left side at the Department of Otolaryngology of our hospital in 2000. Local recurrence or metastasis did not occur post-treatment. In January 2009, the patient was diagnosed with radiation osteomyelitis of the mandible on the left side, complicated by a pathologic fracture. In July 2011, numbness occurred in the left upper extremity and the patient was transferred to the emergency center of our hospital. A computed tomography scan showed a tumor lesion in the brain that was diagnosed as a brain abscess by magnetic resonance imaging. Neurosurgeons performed burr hole drainage of the abscess, followed by administration of antibiotics. Although impaired fine movements of the left hand remain, progress has been relatively favorable with no recurrence of osteomyelitis or brain abscess post-surgery.
  • 去川 俊二, 杉浦 康史, 野口 忠秀, 吉村 浩太郎, 西野 宏, 森 良之
    顎顔面補綴 (一社)日本顎顔面補綴学会 40 (2) 46 - 47 0389-4045 2017/12
  • 杉浦 康史, 去川 俊二, 作山 葵, 早坂 純一, 野口 忠秀, 神部 芳則, 西野 宏, 森 良之
    顎顔面補綴 (一社)日本顎顔面補綴学会 40 (2) 50 - 50 0389-4045 2017/12
  • Sase Miwako, Itoh Hiroto, Nakano Takahumi, Hayasaka Junichi, Noguchi Tadahide, Jinbu Yoshinori, Mori Yoshiyuki
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 29 (5) 438 - 442 2212-5558 2017/09 [Refereed][Not invited]
     
    Ghost cell odontogenic carcinoma (GCOC) is a rare malignant odontogenic tumor with aggressive growth characteristics. We report a case of GCOC of the maxilla in a 65-year-old Japanese man who was referred to our hospital with painful swelling of the left maxilla. Computed tomography showed a bone defect in the left upper jaw and the border with the surrounding tissue was indistinct in one area. Tumor resection was performed under general anesthesia, and the histopathological diagnosis was dentinogenic ghost cell tumor (DGCT). Ten months postoperatively, the tumor recurred in the same area, and partial resection of the maxilla was performed. Twelve months after reoperation, the tumor recurred a second time. The histopathological diagnosis this time was GCOC, as a secondary malignant manifestation of the benign DGCT.
  • Shunji Sarukawa, Hideaki Kamochi, Tadahide Noguchi, Ataru Sunaga, Hirokazu Uda, Yoshiyuki Mori, Hiroshi Nishino, Kotaro Yoshimura
    JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY 45 (9) 1573 - 1577 1010-5182 2017/09 [Refereed][Not invited]
     
    Anteromedial maxillectomy is typically performed in conjunction with low-dose radiotherapy and intraarterial chemotherapy. In doing so, the extent of surgical defects is reduced. However, nasal deviation and oral incompetence may ensue, due to cicatricial contracture of wounds, and may be distressing to these patients. Herein, we report a series of eight free perforator flap procedures (anterolateral thigh [ALT] flap, 6; thoracodorsal artery perforator [TAP] flap, 2) used to correct such deformities. The TAP flap was combined with scapular tip [ST] osseous flap in patients with added zygomatic prominence defects. Three adipocutaneous parts developed from each perforator flap were applied as follows: two to reconstruct nasal lining and oral vestibule, and one to augment cheek volume. All aesthetic results proved satisfactory, although orbital dystopia and contracture of mimic muscles were not resolved completely. These secondary interventions are suitable for sequelae of simple anteromedial maxillectomy. Immediate reconstruction should be considered if orbital floor and mimic muscles are involved. (C) 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
  • 舌切除即時再建における外舌筋切除が嚥下訓練・経口摂取におよぼす影響
    杉浦 康史, 去川 俊二, 加持 秀明, 早坂 純一, 山川 道代, 野口 忠秀, 神部 芳則, 西野 宏, 森 良之
    頭頸部癌 (一社)日本頭頸部癌学会 43 (2) 170 - 170 1349-5747 2017/05
  • 悪性腫瘍切除下顎即時再建後に無歯顎となった症例の検討
    去川 俊二, 杉浦 康史, 加持 秀明, 早坂 純一, 野口 忠秀, 森 良之, 西野 宏, 吉村 浩太郎
    頭頸部癌 (一社)日本頭頸部癌学会 43 (2) 205 - 205 1349-5747 2017/05
  • 杉浦 康史, 去川 俊二, 加持 秀明, 早坂 純一, 野口 忠秀, 西野 宏, 森 良之, 吉村 浩太郎
    形成外科 克誠堂出版(株) 60 (4) 408 - 418 0021-5228 2017/04
  • 自治医科大学附属病院歯科口腔外科における口腔がん患者の経過比較と予後・術後QOL向上についての検討
    赤堀 永倫香, 早坂 純一, 古藤 悠希, 林 宏栄, 杉浦 康史, 斎藤 宏美, 山本 亜紀, 作山 葵, 野口 忠秀, 神部 芳則, 森 良之
    栃木県歯科医学会誌 (一社)栃木県歯科医師会 69 23 - 27 2017/04 
    積極的治療を行った口腔がん患者118例(男性65例、女性53例、14〜91歳)を対象とした。原発部位は、舌が61例と最も多く、次いで歯肉38例、頬粘膜10例、口底部6例、唾液腺2例、上唇1例であった。治療内容は、手術療法58例、手術+放射線療法37例、手術+化学放射線療法21例、手術+化学療法2例であった。初診時のStage分類では、Stage Iは37例、Stage IIは34例、Stage IIIは23例およびStage IVは24例であった。23例に術後せん妄が生じ、このうちの92%が70歳以上の高齢者であり、発症平均年齢は78歳であった。治療前は106例が自宅在住で、その平均年齢は67歳であった。治療後の療養先は自宅107例、病院7例、老人介護福祉施設3例であった。死亡退院は1例であった。術後の摂食嚥下機能低下に伴い胃瘻使用となったのは12例で、胃瘻+経口摂取となったのは15例であった。
  • Tadahide Noguchi, Tomoko Sugiyama, Ken-ichi Sasaguri, Shigeru Ono, Kosaku Maeda, Hiroshi Nishino, Yoshinori Jinbu, Yoshiyuki Mori
    JOURNAL OF CRANIOFACIAL SURGERY 28 (2) E141 - E144 1049-2275 2017/03 [Refereed][Not invited]
     
    1-day-old male infant was referred to our department for evaluation of multiple malformations in his oral cavity. He was diagnosed duplication of the pituitary gland-plus syndrome with epignathus, cleft palate, duplication of the mandible, and a lobulated tongue. A thumb-sized mass lesion was visible on the hard palate. The duplicated mandible and lower lip was fused at the midline. The alveolar ridge was protruding through a wide-cleft soft palate involving the uvula. Further examination showed a lobulated tongue, which was seen behind the duplicated part of the mandible. Five days after birth, tracheotomy and epignathus resection were performed. At 7 months of age, the excess tissue of the duplicated mandible was resected at the area of adhesion on the lingual side, and the duplicated tongue and lip were reconstructed. A palatoplasty was performed at 20 months of age. Thereafter, the patient's progress was uneventful, with no abnormality in swallowing. No recurrence of epignathus has been observed during 2 years of follow-up.
  • 去川 俊二, 杉浦 康史, 作山 葵, 早坂 純一, 野口 忠秀, 西野 宏, 森 良之
    顎顔面補綴 (一社)日本顎顔面補綴学会 39 (2) 42 - 48 0389-4045 2016/12
  • Takafumi Nakano, Yoshinori Jinbu, Naruo Okada, Miwako Sase, Junichi Hayasaka, Yoshiyuki Tsuchiya, Hiroto Itoh, Tadahide Noguchi, Kentaro Hoshi, Yoshiyuki Mori
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 28 (6) 525 - 529 2212-5558 2016/11 [Refereed][Not invited]
     
    We report a very rare case of systemic amyloidosis occurring in bilateral mandibular condyles and showing condylar bone destruction and lesions in the buccal mucosa bilaterally. The patient was a 61-year-old man complaining of malocclusion in which the lower teeth extended abnormally over the upper teeth. He first noticed this about 1 year earlier. Medical history included renal cancer, rheumatic myalgia in multiple joints, osteoporosis, hypothyroidism, chronic hepatitis, malignant lymphoma and hemodialysis for renal failure. Panoramic radiography and computed tomography showed bone destruction in bilateral mandibular condyles and a soft tissue mass lesion around the condyle. Slightly raised mass lesions with areas of whitish and purplish coloration were also observed on the buccal mucosa bilaterally. Histopathological examination revealed amyloid deposition in these lesions, and AA and/or Aβ2M amyloidosis was diagnosed. However, we were informed that the patient died within 3 months from when he had a last check-up at our clinic due to systemic problems.
  • Miwako Sase, Hiroto Itoh, Junichi Hayasaka, Kentaro Hoshi, Tadahide Noguchi, Yoshinori Jinbu, Yoshiyuki Mori
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 28 (6) 493 - 497 2212-5558 2016/11 [Refereed][Not invited]
     
    Small cell carcinoma in the oral and maxillofacial region is an extremely rare, high-grade malignancy. We report a case of small cell carcinoma in the palatal mucosa. An 80-year-old man was referred to our clinic with swelling in the right maxilla. An 80-mm lymph node was seen in the right neck. The clinical diagnosis was malignant tumor of the palatal mucosa and biopsy was performed. The histopathological diagnosis was small cell carcinoma. Systemic examination diagnosed cervical lymph node metastasis, liver metastasis and multiple bone metastases. Considering the clinical stage and performance status, best supportive care was selected. The patient died of multiple-organ failure 3 months after the first visit.
  • T1-2N0M0舌扁平上皮癌の検討
    大鶴 光信, 太田 嘉英, 柳本 惣市, 大倉 正也, 梅田 正博, 桐田 忠明, 栗田 浩, 上田 倫弘, 長谷川 巧実, 柴原 孝彦, 野口 忠秀, 野口 一馬, 山下 善弘, 大廣 洋一, 内藤 博之
    日本癌治療学会学術集会抄録集 (一社)日本癌治療学会 54回 PS - 2 2016/10
  • Michiko Ozawa, Yoshinori Jinbu, Hiromi Hayashi, Akane Senna, Hiroto Itoh, Tadahide Noguchi, Yoshiyuki Mori
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 28 (5) 457 - 461 2212-5558 2016/09 [Refereed][Not invited]
     
    The patient was a 69-year-old woman. She initially consulted our institute with a chief complaint of swelling in bilateral submandibular glands and dry mouth. A localized, movable hard elastic mass was observed in bilateral submandibular and parotid glands. Oral dryness and atrophy of the lingual papilla were observed. The patient had a history of malignant lymphoma (mucosa-associated lymphoid tissue (MALT) lymphoma), for which she had undergone two courses of CHOP therapy (cyclophosphamide, doxorubicin, vincristine, and prednisone) in addition to radiotherapy at 48 years of age. Biopsy of the submandibular gland was performed in our department. The extracted submandibular gland was accompanied by elastic, hard induration. Amyloid deposition accompanying lymphocytic infiltration was histopathologically observed from the submandibular gland.
  • Tadahide Noguchi, Yoshiyuki Tsuchiya, Shunji Sarukawa, Yuko Yamazaki, Jun-ichi Hayasaka, Ken-ichi Sasaguri, Yoshinori Jinbu, Yoshiyuki Mori
    JOURNAL OF CRANIOFACIAL SURGERY 27 (5) 1263 - 1266 1049-2275 2016/07 [Refereed][Not invited]
     
    Objective: The purpose of this study was to investigate the relationship between habitual chewing side and perception of the oral mucosa following reconstruction with dental implants. Study Design: Five patients comprised 2 males and 3 females, with ameloblastoma in 2 patients, odontogenic myxoma in 2 patients, and oral squamous cell carcinoma in 1 patient. They were treated using mandibular reconstruction with bare bone graft after segmental resection of the mandible. Perception (tactile, warm, and cold) was measured at 8 points (chin, lower lip, gingiva, and lateral edge of the tongue, bilaterally). Habitual chewing side was evaluated using a computerized index, the first chewing cycle, and a question on chewing. Results: Perception on resected sides was improved at all measurement points for tactile and cold sensitive evaluation, although sensitivities on the resected side remained below the normal range. In the relationship between habitual chewing side and implanted prostheses in reconstructed bone, the chewing side was the resected side in 2 of the 5 patients. When those 2 patients underwent prosthesis implantation after removal of denture, the chewing side changed from the nonresected side to the resected side. Implant prostheses on resected side were suggested to contribute to masticatory function. Perception in those patients was incomplete but was improved compared with other patients. When prosthesis implantation is performed on the reconstructed side, the resected side may become the habitual chewing side. Conclusions: Recovery of perception can influence acquisition of the habitual chewing side.
  • 超高齢者における腓骨皮弁による下顎再建
    杉浦 康史, 去川 俊二, 加持 秀明, 早坂 純一, 土屋 欣之, 野口 忠秀, 神部 芳則, 西野 宏, 森 良之
    頭頸部癌 (一社)日本頭頸部癌学会 42 (2) 148 - 148 1349-5747 2016/05
  • 下顎再建に用いた血管柄付き遊離腸骨移植片の経時的変化に関する検討
    野口 忠秀, 土屋 欣之, 大谷津 幸生, 杉浦 康史, 岡田 成生, 早坂 純一, 神部 芳則, 加持 秀明, 去川 俊二, 西野 宏, 森 良之
    頭頸部癌 (一社)日本頭頸部癌学会 42 (2) 244 - 244 1349-5747 2016/05
  • T1-2N0M0舌癌に予防郭清を行うことの是非に関する多施設共同研究(JOOG RA1403)
    大鶴 光信, 太田 嘉英, 梅田 正博, 柳本 惣市, 栗田 浩, 鎌田 孝広, 桐田 忠昭, 山川 延宏, 上田 倫弘, 山下 徹郎, 大倉 正也, 相川 友直, 大廣 洋一, 栗林 和代, 山下 善弘, 長井 健太郎, 野口 一馬, 岸本 裕充, 長谷川 巧実, 古森 孝英, 傳田 祐也, 内藤 博之, 柴原 孝彦, 野口 忠秀, 唐木田 一成
    頭頸部癌 (一社)日本頭頸部癌学会 42 (2) 170 - 170 1349-5747 2016/05
  • 加持 秀明, 去川 俊二, 杉浦 康史, 野口 忠秀, 西野 宏, 森 良之, 菅原 康志, 吉村 浩太郎
    頭頸部癌 日本頭頸部癌学会 42 (2) 148  1349-5747 2016/05 [Not refereed][Not invited]
  • 去川 俊二, 加持 秀明, 杉浦 康史, 野口 忠秀, 菅原 康志, 森 良之, 西野 宏, 吉村 浩太郎
    頭頸部癌 日本頭頸部癌学会 42 (2) 131  1349-5747 2016/05 [Not refereed][Not invited]
  • Hiroto Itoh, Akitoshi Katsumata, Kei Kashimura, Yukihiro Iida, Tadahide Noguchi, Shunji Sarukawa, Yoshinori Jinbu, Mikio Kusama
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 27 (5) 608 - 613 2212-5558 2015/09 [Refereed][Not invited]
     
    Objective: Swallowing statuses in patients with advanced cancers that require reconstruction have not been studied well. The relationship between topography of the reconstructed upper airway and swallowing status was evaluated. Material and methods: Subjects comprised 19 cases of tongue cancer and 10 cases of mandibular cancer who underwent resection of the primary lesion and reconstructive surgery with the vascularized free flap. CT image data preoperatively and postoperatively were utilized to evaluate morphological airway changes. Videofluorographic swallowing study (VFSS) was performed postoperatively. Aspiration and laryngeal penetration were noted and compared with morphological airway changes. Results: Regarding postoperative airway morphology, no significant differences in postoperative airway changes were apparent between tongue and mandibular cancers. In postoperative VFSS, aspiration and/or laryngeal penetration was seen in 32% of the tongue cancer cases and 20% of the mandibular cancer cases. Conclusion: Cases with aspiration and/or laryngeal penetration revealed less reduction of postoperative cross-sectional area compared to other cases.
  • Shunji Sarukawa, Tadahide Noguchi, Hideaki Kamochi, Ataru Sunaga, Hirokazu Uda, Hiroshi Nishino, Yasushi Sugawara
    JOURNAL OF CRANIOFACIAL SURGERY 26 (6) 539 - 542 1049-2275 2015/09 [Refereed][Not invited]
     
    The natural mandible has 2 arcs, the marginal arc and the occlusal arc. The marginal arc is situated along the lower margin of the mandible and affects the contour of the lower third of the face. The occlusal arc is situated along the dental arc and affects the stability of prosthodontics. The gap between these 2 arcs widens in the molar area. Our developed concept of "double arc reconstruction" involves making these 2 arcs for the reconstructed mandible. For the double-barrel fibula reconstruction, 2 bone segments are used to make both arcs. For reconstructions using the iliac crest, the double arc is made by inclination of the top of the bone graft toward the lingual side. Ten patients underwent double arc reconstruction: 2 underwent reconstruction with the double-barrel fibula, and 8 underwent reconstruction with the iliac crest. Four patients had a removable denture prosthesis, 1 had an osseointegrated dental implant, and 5 did not require further prosthodontic treatment. The shape of the reconstructed mandible after double arc reconstruction resembles the native mandible, and masticatory function is good with the use of a dental implant or removable denture prosthesis, or even without prosthodontics.
  • Tadahide Noguchi, Akane Senna, Yoshiyuki Tsuchiya, Masaki Toshima, Toshiro Niki, Yoshinori Jinbu
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 27 (4) 513 - 517 2212-5558 2015/07 [Refereed][Not invited]
     
    We encountered a very rare case involving a 67-year-old male with Richter's syndrome showing transformation of B-cell chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) in the left mandibular condyle region. CLL had been diagnosed at another hospital 9 years before visiting our hospital. He had not received positive treatment for CLL. Local examination revealed a mass in the left preauricular region. Histological and immunohistological examination of biopsy tissue from the left preauricular region revealed infiltration of DLBCL, in this case caused by transformation of B-CLL. We diagnosed Richter's syndrome with transformation of B-CLL to DLBCL. Although local irradiation was performed and intravenous cyclophosphamide, vincristine, doxorubicin, and prednisone were administered, the patient died 12 months after diagnosis of Richter's syndrome.
  • Tomoko Sugiyama, Motohiro Uo, Takahiro Wada, Daisuke Omagari, Kazuo Komiyama, Serika Miyazaki, Chiya Numako, Tadahide Noguchi, Yoshinori Jinbu, Mikio Kusama, Yoshiyuki Mori
    SCIENTIFIC REPORTS 5 10672  2045-2322 2015/06 [Refereed][Not invited]
     
    Oral lichen planus (OLP) and oral lichenoid contact lesions (OLCL) are chronic inflammatory mucocutaneous reactions with a risk of malignant transformation that alter the epithelium. OLP and OLCL have similar clinical and histopathological features and it is difficult to distinguish one from the other. Metallic restorations are suspected to generate OLCLs. Trace metal analysis of OLCL specimens may facilitate the discrimination of symptoms and identification of causative metallic restorations. The purpose of this study was to assess OLCL tissue samples for the prevalence of metallic elements derived from dental restorations, and to discriminate OLCL from OLP by using synchrotron radiation-excited X-ray fluorescence analysis (SR-XRF), particle-induced X-ray emission (PIXE), and X-ray absorption fine structure (XAFS). Typical elements of dental materials were detected in the OLCL, whereas no obvious element accumulation was detected in OLP and negative control specimens. The origin of the detected metallic elements was presumed to be dental alloys through erosion. Therefore, our findings support the feasibility of providing supporting information to distinguish OLCL from OLP by using elemental analysis.
  • 当科で経験した歯性感染による深頸部膿瘍の2例
    杉浦 康史, 宮城 徳人, 井上 恵美, 早坂 純一, 土屋 欣之, 伊藤 弘人, 野口 忠秀, 神部 芳則, 森 良之
    栃木県歯科医学会誌 (一社)栃木県歯科医師会 67 105 - 111 2015/04 
    症例1は86歳男で、左側頬部の腫脹・疼痛と開口障害を主訴に受診した。左側頬部・顎下部・頸部に腫脹と熱感があり、血液検査でCRPの著明高値を認めた。パノラマX線で左側下顎第一大臼歯と第二大臼歯の根尖部に透過像を認め、同部からの感染と考えられた。症例2は79歳男で、近歯科で右側下顎第二大臼歯を抜歯されたあと同部の疼痛と右側顔面の腫脹が増悪し、抗菌薬を投与されたが改善なく、当科に紹介された。右側頭部・頬部・顎下部・頸部に腫脹と熱感を認め、血液検査で白血球数とCPRの著明高値を認めた。パノラマX線で右側下顎第二大臼歯部に抜歯窩を認め、同部からの感染と考えられた。治療は2例とも全身麻酔下に切開・排膿術を行い、両例とも残存膿瘍や新たな膿瘍形成を認めたため拡大ドレナージ手術を要したが、最終的に消炎が得られた。
  • Tomoko Sugiyama, Motohiro Uo, Takahiro Wada, Daisuke Omagari, Kazuo Komiyama, Tadahide Noguchi, Yoshinori Jinbu, Mikio Kusama
    BIOMETALS 28 (1) 11 - 20 0966-0844 2015/02 [Refereed][Not invited]
     
    The effects of dissolved elements from metal dental restorations are a major concern in lesions of the oral mucosa, and the evaluation of accumulated metal elements, especially their distribution and chemical state, is essential for determining the precise effects of trace metals. In this study, X-ray fluorescence with synchrotron radiation (SR-XRF) and particle-induced X-ray emission (PIXE) were applied for distribution analysis of the trace metal elements contained in the oral mucosa, and the chemical states of the elements were estimated using X-ray absorption fine structure (XAFS) analysis. Appropriate combination of these analysis techniques, particularly SR-XRF and PIXE, to visualize the distributions of the elements in the oral mucosa allowed for the observation and evaluation of accumulated metal ions and debris. Importantly, the analyses in this study could be carried out using conventional histopathological specimens without damaging the specimens. Therefore, this method would be applicable for the detection of accumulated trace metal elements in biopsy specimens from the oral mucosa.
  • Hideki Watanabe, Hiroto Itoh, Yoshiyuki Tsuchiya, Norito Miyagi, Tomoko Sugiyama, Yuichiro Nakai, Yasuhisa Shinozaki, Tadahide Noguchi, Yoshinori Jinbu, Mikio Kusama
    Japanese Journal of Cancer and Chemotherapy 42 (1) 131 - 133 0385-0684 2015/01 [Refereed][Not invited]
     
    A case showing reinforcement of the action of warfarin and potassium in a patient administered S-1 is reported. The patient was a 71 -year-old man with left upper gingival cancer. He had ventricular tachycardia (VT), hypertrophic cardiomyopathy, and a cerebellar infarction. He underwent a pacemaker implantation, and was administered warfarin. After the operation, in mid-March 2010, he was administered with S-1 and warfarin. However, the international normalized ratio of prothrombin time (PT-INR) increased to an extremely high level of 5.82, and S-1 and warfarin were stopped. They were re-administered at the end of April, and the PT-INR stabilized to approximately 2.
  • 下顎歯肉癌術後の周術期管理に難渋した1例
    宮城 徳人, 神部 芳則, 井上 恵美, 杉浦 康史, 早坂 純一, 伊藤 弘人, 野口 忠秀, 草間 幹夫
    有病者歯科医療 (一社)日本有病者歯科医療学会 23 (4) 347 - 348 0918-8150 2014/12
  • Tadahide Noguchi, Yoshiyuki Tsuchiya, Junichi Hayasaka, Hiroto Itoh, Yoshinori Jinbu, Mikio Kusama, Satoru Takahashi, Masanori Nakazawa
    Japanese Journal of Head and Neck Cancer 40 (3) 324 - 328 1881-8382 2014/10 [Refereed][Not invited]
     
    Eight patients~6 males, 2 females median age, 78 years age range, 31 ~ 94 years)were treated by mold radiotherapy with a prosthetic apparatus for oral cancers between October 2006 and March 2013. The primary sites were the tongue in 3 cases, hard palate and buccal mucosa in 2 cases each, and oral floor in 1 case. The type of treatment consisted of radical radiotherapy and palliative radiotherapy in 2 cases each, and preoperative radiotherapy, postoperative radiotherapy, additional radiotherapy after external beam radiotherapy and systemic chemotherapy in 1 case each. Patients received 40 ~ 50 Gy in 8 ~ 10 fractions with mold radiotherapy. Two patients who received radical radiotherapy showed no signs of recurrence or metastasis. The present therapy contributed to patients’palliative, postoperative, and preoperative therapy. Mold radiotherapy with a prosthetic appliance was performed safely and was a useful treatment for several types of oral cancer.
  • 宮城 徳人, 神部 芳則, 井上 恵美, 杉浦 康史, 早坂 純一, 土屋 欣之, 伊藤 弘人, 野口 忠秀, 森 良之
    小児口腔外科 (一社)日本小児口腔外科学会 24 (2) 115 - 115 0917-5261 2014/10
  • メソトレキセート関連リンパ増殖性疾患併発を疑ったビスフォスフォネート製剤による上下顎骨壊死に歯肉アメーバ感染を伴った1例
    宮城 徳人, 伊藤 弘人, 井上 恵美, 杉浦 康史, 佐瀬 美和子, 仙名 あかね, 菊池 公治, 早坂 純一, 野口 忠秀, 神部 芳則, 草間 幹夫
    日本口腔科学会雑誌 (NPO)日本口腔科学会 63 (4) 400 - 400 0029-0297 2014/09
  • N. Okada, K. Sasaguri, T. Otsuka, A. Fujita, H. Ito, T. Noguchi, Y. Jinbu, M. Kusama
    INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 43 (8) 933 - 940 0901-5027 2014/08 [Refereed][Not invited]
     
    The present study aimed to verify the importance of postoperative articulatory rehabilitation in patients with oral cancer and to clarify the neurological changes underlying articulatory functional recovery. A longitudinal assessment of oral function and accompanying brain activity was performed using non-invasive functional magnetic resonance imaging (fMRI). We assessed 13 patients with cancers of the tongue and oral floor before and after ablative surgery. Articulatory function was assessed preoperatively and postoperatively using a conversation intelligibility test and the Assessment of Motor Speech for Dysarthria test. Patients also performed a verbal task during fMRI scans. The assessments were then repeated after the patients had undergone 4-6 months of articulatory rehabilitation therapy. Compared to pretreatment levels, articulatory rehabilitation resulted in a significant increase in activation in the supplementary motor cortex, thalamus, and cingulate cortex. The present study offers a quantitative assessment of the effects of speech rehabilitation by investigating changes in brain activation sites.
  • Yasuhisa Shinozaki, Yoshinori Jinbu, Hiroto Ito, Tadahide Noguchi, Mikio Kusama, Naoyuki Matsumoto, Kazuo Komiyama, Nobuyuki Taniguchi
    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 117 (5) 634 - 639 2212-4403 2014/05 [Refereed][Not invited]
     
    Objective. To clarify whether intraoral ultrasonography (I-US) is effective for predicting metastasis of tongue cancer to the cervical lymph nodes. Study Design. Participants comprised 29 patients with tongue carcinoma classified as T1-T4 using the TNM staging system. All patients underwent I-US preoperatively. Postoperatively, resected specimens were evaluated histopathologically. Results. I-US found that cases with invasive depth >= 3 mm had higher potential for cervical lymph node metastasis than those with invasive depth <3 mm (P < .05). No other significant relationships were identified between observations on I-US and cervical lymph node metastasis. Cases with histopathologic blood vessel infiltration or lymph duct infiltration had a significant difference in risk of cervical lymph node metastasis. Conclusions. I-US is useful for preoperatively assessing the invasive depth of tongue carcinoma. Furthermore, observations from I-US and invasive depth of the tumor allowed presumptive diagnosis with regard to cervical lymph node metastasis.
  • 口腔内出血に対して入院管理下での止血処置を要した2例
    井上 恵美, 宮城 徳人, 杉浦 康史, 林 宏美, 早坂 純一, 土屋 欣之, 伊藤 弘人, 野口 忠秀, 大橋 一之, 小佐野 仁志, 神部 芳則, 草間 幹夫
    栃木県歯科医学会誌 (一社)栃木県歯科医師会 66 109 - 114 2014/04 
    口腔内出血に対して入院管理下での止血処置を要した2例を経験した。症例1は74歳男で、抜歯後より繰り返す出血で受診した。オルソパントモ・デンタルX線写真では抜歯窩に残根等は認めず、顎関節内にも器質的な異常所見は認めなかった。また、同時にCT画像精査でも顎骨内に器質的異常所見は認めなかった。抜歯窩再掻爬を施行、吸収性ゼラチンスポンジを挿入、縫合を行い、義歯の使用中止を指示した。その後も出血を繰り返したため緊急入院した。精査にて血友病Aの確定診断でコージネイトを投与した。止血を得たため第26病日に軽快退院した。症例2は84歳女で、左下3辺縁歯肉からの出血を認めた。局所止血目的で縫合処置を行った。採血にて凝固系の過度の延長を認めた。再度出血し、機械的刺激除去を目的に緊急入院とした。止血処置を施行後、第16病日に軽快退院した。
  • 那須赤十字病院における周術期口腔機能管理と歯科衛生士の役割
    小野寺 郁, 宮城 徳人, 杉浦 康史, 茅野 千尋, 佐藤 美希, 大橋 望, 秋元 留美, 槐 節子, 井上 恵美, 早坂 純一, 伊藤 弘人, 野口 忠秀, 大橋 一之, 小佐野 仁志, 神部 芳則, 草間 幹夫
    栃木県歯科医学会誌 (一社)栃木県歯科医師会 66 129 - 132 2014/04 
    那須赤十字病院における周術期口腔機能管理と歯科衛生士の役割について検討した。周術期口腔機能管理を行った269例を対象とした。40歳代から60歳代の受診が多く、全体の68%を占めた。全疾患に占める疾患の割合は、悪性疾患111例、その他158例であった。悪性疾患の内訳は乳癌38例、胃癌17例、直腸癌13例、S状結腸癌11例、子宮体癌11例、子宮頸癌6例、頭頸部癌6例、肺癌3例、大腸癌2例、膵頭部癌2例、膵臓癌2例、下行結腸癌2例などであった。術前ケア介入平均日数は徐々に早まり4月では平均4日であったが、9月では平均11日と口腔ケアが早い段階で介入できるようになった。術後ケアは4月から9月にかけて平均5日から7日に介入した。6月以降は外来来院時の口腔ケアも定着し、口腔ケア3回介入が増加した。口腔内所見より、歯周炎で動揺歯を認める症例が多数あり、手術・処置を必要とする口腔内増悪環境であった。
  • ポリグリコール酸シート(PGAシート)とフィブリン糊スプレーによる創面被覆による口腔腫瘍切除後の経過観察中に、腫瘍切除面に難治性の肉芽腫性病変を認めた1例
    宮城 徳人, 神部 芳則, 杉浦 康史, 井上 恵美, 土屋 欣之, 伊藤 弘人, 野口 忠秀, 大橋 一之, 小佐野 仁志, 草間 幹夫
    日本口腔診断学会雑誌 (一社)日本口腔診断学会 27 (1) 87 - 87 0914-9694 2014/02
  • クモの咬傷によるMRSA細菌感染が原因と考えられた左頬部蜂窩織炎の1例
    小川 あゆみ, 早坂 純一, 林 宏栄, 杉浦 康史, 伊藤 弘人, 野口 忠秀, 神部 芳則, 草間 幹夫
    日本口腔診断学会雑誌 (一社)日本口腔診断学会 27 (1) 108 - 108 0914-9694 2014/02
  • NOGUCHI Tadahide, TSUCHIYA Yoshiyuki, OZAWA Michiko, ITOH Hiroto, JINBU Yoshinori, KUSAMA Mikio
    J.Jpn.Stomatol.Soc Japanese Stomatological Society 63 (2) 216 - 221 0029-0297 2014 
    We analyzed the clinical stage and prognostic value of primary 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) standardized uptake value (SUV) in patients with oral squamous cell carcinoma. The subjects were 119 patients newly diagnosed with oral squamous cell carcinoma who underwent positron emission tomography between May 2004 and December 2011 before treatment. The cut-off between high- and low-uptake tumors was set at an SUV of 5.0. High uptake of FDG is associated with advanced disease, cervical lymph node metastasis and poor prognosis. High SUV (≥ 5.0) was significantly predictive of low rates of disease-specific and disease-free survivals, as compared with low SUV(< 5.0). These findings indicate that pretreatment tumor FDG uptake represents an independent prognostic factor in patients with oral cancer. Patients with tumors showing high FDG uptake should be considered as high risk when planning treatment and follow-up.
  • ポリグリコール酸シート(PGAシート)とフィブリン糊スプレーによる創面被覆による口腔腫瘍切除後の経過観察中に、腫瘍切除面に難治性の肉芽腫性病変を認めた1例
    宮城 徳人, 神部 芳則, 杉浦 康史, 井上 恵美, 土屋 欣之, 伊藤 弘人, 野口 忠秀, 大橋 一之, 小佐野 仁志, 草間 幹夫
    日本口腔内科学会雑誌 (一社)日本口腔内科学会 19 (2) 86 - 86 2186-6147 2013/12
  • クモの咬傷によるMRSA細菌感染が原因と考えられた左頬部蜂窩織炎の1例
    小川 あゆみ, 早坂 純一, 林 宏栄, 杉浦 康史, 伊藤 弘人, 野口 忠秀, 神部 芳則, 草間 幹夫
    日本口腔内科学会雑誌 (一社)日本口腔内科学会 19 (2) 107 - 107 2186-6147 2013/12
  • Tomoko Sugiyama, Yoshinori Jinbu, Kouichi Matsumoto, Hiroto Itoh, Tadahide Noguchi, Mikio Kusama
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 25 (4) 368 - 373 2212-5558 2013/10 [Refereed][Not invited]
  • 杉浦 康史, 岡田 成生, 中山 竜司, 小川 あゆみ, 佐瀬 美和子, 篠崎 泰久, 伊藤 弘人, 野口 忠秀, 小佐野 仁志, 神部 芳則, 草間 幹夫
    日本口腔科学会雑誌 (NPO)日本口腔科学会 61 (3) 308 - 308 0029-0297 2012/07
  • ニコランジルによる口腔潰瘍と考えられた2例
    杉浦 康史, 中山 竜司, 佐瀬 美和子, 岡田 成生, 井岡 友梨, 大橋 一之, 伊藤 弘人, 野口 忠秀, 神部 芳則, 草間 幹夫
    栃木県歯科医学会誌 (一社)栃木県歯科医師会 64 13 - 17 2012/04 
    症例1は87歳男で、口腔内の違和感と疼痛を主訴とした。症例2は77歳男で、多発性に口内炎ができると訴えた。いずれも抗狭心症治療薬のニコランジルを服用しており、受診時には頬粘膜や舌縁部に境界明瞭、表面平滑な潰瘍を認めたが、潰瘍周囲に硬結は認めず、ステロイド軟膏の効果は乏しかった。また、症例1では小アフタ出現から明らかな増大傾向を認めたため生検を行ったが、悪性所見はなかった。2例ともニコランジルによる口腔粘膜潰瘍を疑って同薬を休薬としたところ、頬粘膜、舌の潰瘍は明らかな改善傾向を示し、症例1は8週間、症例2は7週間で潰瘍は上皮化したが、いずれも発症から治癒まで4ヵ月程度を要した。
  • Tadahide Noguchi, Y. Tsuchiya, H. Itoh, Y. Jinbu, K. Tsukinoki, S. Sarukawa, Y. Sugawara, I. Ohiwa, M. Kusama
    Oral Surgery 5 (1) 30 - 38 1752-2471 2012/02 [Refereed][Not invited]
     
    Bare bone graft is a method of mandibular reconstruction involving vascularised iliac bone graft without a skin flap, and secondary epithelialisation of the exposed iliac bone surface in the oral cavity.We herein report two cases of bare bone graft with dental implant for mandibular defect after tumour resection. Case 1: A 36-year-old woman with odontogenic myxoma of the left mandible underwent reconstruction with a free vascularised iliac flap after segmental resection of the mandible. The exposed iliac bone surface in theoral cavity required about 2 months for epithelialisation. Two implants were placed into the reconstructed mandible 12 months after initial surgery, and prosthetic rehabilitationwas performed successfully after 6 months of osseointegration period. Case 2: A 32-year-old woman with desmoplastic ameloblastoma of the right mandible underwent reconstruction using free iliac bone after segmental resection of the mandible. As the reconstructed bonefailed after surgery, the left mandible was reconstructed using a free vascularised iliacflap. The exposed iliac bone surface in the oral cavity required about 2 months for epithelialisation. Four implants were placed into the reconstructed mandible 17 months after surgery, and prosthetic rehabilitation was performed successfully after 6 months of osseointegration period. In both cases, the mandibular contour and occlusal function were satisfactory. © 2011 John Wiley & Sons A/S.
  • NAKAYAMA Ryuji, TAMBA Kaichiro, WATANABE Hideki, HOSHI Kentaro, OKADA Naruo, YAMASHITA Masako, KASHIMURA Kei, ITOH Hiroto, NOGUCHI Tadahide, OSANO Hitoshi, JINBU Yoshinori, KUSAMA Mikio
    Journal of Japanese Society for Oral Mucous Membrane Japanese Society of Oral Medicine 18 (2) 52 - 56 2186-6147 2012 
    Malignant tumors of the oral and maxillofacial region account for 1 to 2% of all carcinomas, and the mental and physical burdens associated with such tumors are major problems for patients. Intractable pain is often present, in patients in advanced or terminal stage and we frequently encounter patients in whom the administration of drugs contraindicated. A clinical evaluation regarding the pain control in patients at our institution with such tumors was conducted. A total of 37 patients (17 men and 20 women)with a malignant tumor of the oral and maxillofacial region, in whom pain control was attempted in our department and the Palliative Care Department between 2005 and March 2010, was evaluated. The patients' age ranged from 51 to 96 years, with a median of 71.8 years. Their outcomes were: death due to or by the primary disease (n = 26), survival with tumor (n = 7), and unknown (n = 3). The number of opioid rotations was zero to four, with an average of 1.56. Six patients had pathological jaw bone fractures. Hypercalcemia was seen in 14 patients; of these, nine patients received zoledronate, two received calcitonin, and three received pamidronate disodium.
  • Shunji Sarukawa, Tadahide Noguchi, Ichiro Oh-iwa, Ataru Sunaga, Hirokazu Uda, Mikio Kusama, Yasushi Sugawara
    JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY 40 (1) 61 - 66 1010-5182 2012/01 [Refereed][Not invited]
     
    Background: "Bare bone graft" with a vascularised iliac crest is a procedure involving no soft tissue for intraoral lining, and the intraoral defect is covered with epithelial cells through secondary healing of the exposed bone. Methods: A vascularised iliac crest flap is transferred to a segmental mandibular defect intraorally in the position of the osteotomized stump upwardly. Granulation tissue is usually observed on the stump of the bone graft about 1 week after surgery. When sufficient granulation is observed after approximately 4 weeks, "resurfacing" is performed to prevent interference of hypergranulation tissue with epithelization. Resurfacing involves wiping the granulation tissue from the surface of the bone and covering with a plastic prosthesis fitted to the alveolus. Results: A total of 11 patients underwent bare bone graft with a vascularised iliac crest. Resurfacing was performed at an average of 2.1 times for each patient. All wounds in the oral cavity were completely epithelialized from 2 weeks to 3 months after surgery. Complications with the recipient side occurred in four patients. Conclusions: Bare bone graft with the iliac crest is one favourable option for mandibular reconstruction utilising the particular shape of the bone without the attached soft tissue. (C) 2011 European Association for Cranio-Maxillo-Facial Surgery.
  • Hiroto Itoh, Junichi Hayasaka, Tadahide Noguchi, Keiichi Tsukinoki, Yoshinori Jinbu, Mikio Kusama
    Asian Journal of Oral and Maxillofacial Surgery 23 (4) 191 - 195 0915-6992 2011/11 [Refereed][Not invited]
     
    A 45-year-old Japanese woman presented complaining of swelling of the right mandible. Initial histopathological diagnosis was cemental dysplasia. Because of rapid enlargement of the lesion, surgical resection was performed. The post-surgical second histopathological diagnosis was osteosarcoma. In spite of additional treatment with radiotherapy and chemotherapy, the patient died 32 months after the initial visit. Autopsy revealed osteosarcoma with metastases infiltrating of a number of organs, including the lungs, heart, and vertebrae. © 2011 Asian Association of Oral and Maxillofacial Surgeons.
  • Yasuhisa Shinozaki, Hiroto Ito, Ryuji Nakayama, Tadahide Noguchi, Yoshinori Jinbu, Mikio Kusama, Hiroshi Nishino, Keiichi Ichimura
    Asian Journal of Oral and Maxillofacial Surgery 21 (1-2) 43 - 47 0915-6992 2009 [Refereed][Not invited]
     
    A 76-year-old man undergoing haemodialysis for chronic renal failure presented with swelling in the right lower gingiva. Biopsy of the oral mass revealed clear cell carcinoma, and whole body computed tomography and magnetic resonance imaging revealed a mass in the left kidney. The patient was treated with local radiotherapy and immunotherapy and remains alive with cancer at the time of writing. © 2009 Asian Association of Oral and Maxillofacial Surgeons.
  • Tadahide Noguchi, Yoshiyuki Tsuchiya, Hiroto Itoh, Koichi Matsumoto, Hitoshi Osano, Yoshinori Jinbu, Akifumi Fujita, Keiichi Tsukinoki, Toshihiko Sato, Mikio Kusama
    Asian Journal of Oral and Maxillofacial Surgery 21 (1-2) 10 - 17 0915-6992 2009 [Refereed][Not invited]
     
    Objective: The objectives of this study were to evaluate the efficacy and limitations of fluoro-2-deoxy-D-glucose-positron emission tomography for metastatic neck disease secondary to oral squamous cell carcinoma. This study specifically examined the limitations of the procedure. Materials and Methods: From April 2004 to October 2007, 35 patients with oral squamous cell carcinoma underwent computed tomography, ultrasound, and fluoro-2-deoxy-D-glucose-positron emission tomography before treatment with neck dissection. After neck dissection, the results of computed tomography/ultrasound and positron emission tomography imaging were correlated with the histopathological findings of the cervical lymph nodes. Results: Positron emission tomography of the cervical lymph nodes was positive for 20 patients, 16 of who were demonstrated to have metastases on histopathological examination. Of the 4 falsepositive results, 3 were reactive lymphadenitis and 1 was sarcoidosis. Positron emission tomography was negative for 15 patients. Two of these patients had false-negative results, as metastatic disease was found at neck dissection. In 1 patient, the metastatic lymph node was largely keratinised, while micrometastasis was evident in the other patient. Pathological findings were compared with imaging results to determine the relative efficacies of positron emission tomography (accuracy, 82.9% sensitivity, 88.8% specificity, 76.5%), computed tomography (accuracy, 85.7% sensitivity, 88.8% specificity, 82.4%), and ultrasound (accuracy, 88.6% sensitivity, 88.8% specificity, 88.2%). There were no significant differences on statistical analysis. Conclusion: Positron emission tomography appears to have significant potential for the detection of lymph node metastasis. However, fluoro-2-deoxy-D-glucose-positron emission tomography should not be used as the sole method of imaging for initial investigation of oral squamous cell carcinoma and cervical lymph node metastasis. The surgical management of neck lymph node metastasis should not be based on fluoro-2-deoxy-D-glucose-positron emission tomography findings alone. Use of other imaging modalities in addition to fluoro-2-deoxy-D-glucose-positron emission tomography should increase the diagnostic accuracy over fluoro-2-deoxy-D-glucose-positron emission tomography alone. © 2009 Asian Association of Oral and Maxillofacial Surgeons.
  • Yoshiyuki Tsuchiya, Tadahide Noguchi, Kouichi Matsumoto, Toshio Matsumura, Kentarou Hoshi, Hiroto Ito, Hitoshi Osano, Yoshinori Jinbu, Mikio Kusama
    Japanese Journal of Cancer and Chemotherapy 36 (1) 101 - 103 0385-0684 2009 [Refereed][Not invited]
     
    Six patients with advanced oral squamous cell carcinoma were treated with preoperative concurrent chemoradiotherapy. Chemotherapy consisting of CDDP (60 to 70 mg/m2, day 1) and 5-FU (600 to 700 mg/m2, day 1 to 5) with concurrent radiotherapy was accelerated hyperfractionation to target volume of 43-63 Gy. The clinical effect of this therapy on the primary tumor and cervical lymph node was examined in patients who visited our university hospital from 1994 to 2004. The five untreated and one recurrence patients were 3 males and 3 females. Their ages ranged from 23 to 76 years. The primary sites were the tongue in 3, lower gingiva in 2, and upper gingiva in 1 patient (s). Five cases were in advanced Stage IV A and 1 case in Stage III. The preoperative clinical responses of primary tumor: 1 case showed a complete response (CR). The response rate was 100%. We did not operate the case because of CR. Histological effect of the primary tumor (according to the grading system of Ohboshi and Shimosato) : 2 patients were CR. Pathological CR rate of primary site was 33%. However, the CR rate of the metastatic lymph nodes was 0%. In terms of adverse effects, all cases developed nausea, mucositis and leucopenia. The most severe were leucopenia (Grade III), sepsis and DIC. This combination chemoradiotherapy has been proven to be very histologically effective for the primary tumor.
  • Tadahide Noguchi, Yoshinori Jinbu, Kenichi Sasaguri, Yoshiyuki Tsuchiya, Keiichi Tsukinoki, Kaoru Kobayashi, Mikio Kusama
    Asian Journal of Oral and Maxillofacial Surgery 20 (1) 16 - 20 0915-6992 2008 [Refereed][Not invited]
     
    This report is of a 43-year-old woman with osteoma of the mandibular condyle causing facial asymmetry and malocclusion. Preoperative orthodontic treatment was performed after a clinical diagnosis of benign tumour of the left mandibular condyle was made. After 9 months of orthodontic treatment, condylectomy was performed under general anaesthesia. Histopathological examination revealed an osteoma. Postoperative orthodontic treatment was performed for 8 months, and the postoperative course has been favourable. The facial asymmetry and malocclusion have improved. © 2008 Asian Association of Oral and Maxillofacial Surgeons.
  • Yoshinori Jinbu, Keiichi Tsukinoki, Jiro Mitamura, Tomohiro Senna, Yuri Obi, Koichi Matsumoto, Hiroto Itoh, Tadahide Noguchi, Mikio Kusama
    Asian Journal of Oral and Maxillofacial Surgery 19 (1) 25 - 29 0915-6992 2007 [Refereed][Not invited]
     
    Objective: To analyse the relationship between the expression levels of manganese superoxide dismutase, and copper-zinc superoxide dismutase, and clinicopathological parameters in human tongue cancer. Materials and Methods: Oral biopsy specimens of 42 cases of tongue cancer were stained with antihuman manganese and copper-zinc superoxide dismutases, and the degree of staining in tumour cells was evaluated. Clinicopathological information was reviewed and the degree of tumour invasion was divided into four types. Results: The percentage of enhanced manganese superoxide dismutase expression in patients was significantly higher in patients older than 60 years than that in patients younger than 60 years. The percentage of enhanced manganese superoxide dismutase expression was higher in T4 patients versus T1 patients and in patients with lymph node metastasis versus patients without metastasis. A higher percentage of enhanced copper-zinc superoxide dismutase expression was shown in the 2+3 mode of invasion group compared with the advanced mode of invasion (4c+4d) group, and the percentage of reduced copper-zinc superoxide dismutase expression in patients in the 4c+4d group was significantly higher than that in patients in the less invasive group (2+3). The percentage of enhanced copper-zinc superoxide dismutase expression in patients without lymph node metastasis was slightly higher than that in patients with metastasis. Conclusion: These results demonstrate that expression levels of manganese and copper-zinc superoxide dismutases correlate with clinical stage, mode of invasion, and lymph node metastasis in tongue cancer. © 2007 Asian Association of Oral and Maxillofacial Surgeons.
  • T Noguchi, Y Jinbu, H Itoh, K Matsumoto, S Sakai, M Kusama
    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS 101 (4) 481 - 486 1079-2104 2006/04 [Refereed][Not invited]
     
    A case of epignathus combined with cleft palate, lobulated tongue, and lingual hamartoma is reported. A newborn female presented with a large skin-covered mass arising from the palate, cleft palate, and lobulated tongue with soybean-sized lingual lesion. The palatal and lingual masses were removed on the 9th day after birth. A cystic lesion was also found oil the nasal septum after removal of the palatal mass; this lesion was resected at its base. Glossoplasty was performed after excision of the lingual lesion. Histologically, the palatal mass was diagnosed as epignathus. The cystic lesion was suspected to be meningothelial tissues oil the basis of hematoxylin-eosin (HE) and immunohistochemical staining: Vimentin and epithelial membrane antigen were positive, and factor VIII was negative. The mass of the tongue dorsum was diagnosed as hamartoma. No recurrence of epignathus or evidence of meningocele have been observed after 5 years of follow up.
  • Yoshinori Jinbu, Kaoru Ikeda, Miki Aoki, Jiro Mitamura, Tadahide Noguchi, Mikio Kusama
    Asian Journal of Oral and Maxillofacial Surgery 18 (1) 67 - 71 0915-6992 2006 [Refereed][Not invited]
     
    This report is of a 65-year-old man with a granulocytic sarcoma presenting as a gingival swelling. The patient was diagnosed as having natural killer-cell acute leukaemia by bone marrow biopsy. The gingival swelling resolved after chemotherapy. © 2006 Asian Association of Oral and Maxillofacial Surgeons.
  • Michiko Nishimura, Yoshihiro Abiko, Kaoru Kusano, Mami Yamazaki, Masato Saitoh, Itaru Mizoguchi, Yoshinori Jinbu, Tadahide Noguchi, Tohru Kaku
    Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan 36 (2) 94 - 7 0918-4287 2003/06 [Refereed][Not invited]
     
    Human beta-defensin 3 (hBD-3), an antimicrobial peptide, is produced by various epithelial and some nonepithelial tissues. hBD-3 mRNA is widely expressed in oral tissues, including oral epithelium and the salivary glands. Although the localization of hBD-1 and hBD-2 has been well demonstrated in tissue sections, the localization pattern of hBD-3 has not yet been shown. In the present study, we investigated the expression pattern of hBD-3 mRNA by in situ hybridization using specific RNA probes; the signal for hBD-3 was detected in upper spinous and granular layers in normal oral epithelium. In cases of leukoplakia, a strong signal of hBD-3 mRNA was observed in the granular layer. In lichen planus, the signal was strongly detected in the spinous and suprabasal layers. The signals were stronger than those of either normal oral epithelium or leukoplakia. The results indicate that the localization pattern of hBD-3 is very similar to that of hBD-2. hBD-2 and hBD-3 may function together or compensate each other for expressional loss.
  • Y Jinbu, M Kusama, H Itoh, K Matsumoto, J Wang, T Noguchi
    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS 95 (4) 467 - 470 1079-2104 2003/04 [Refereed][Not invited]
     
    We investigated the clinical and histopathologic features of 26 cases of mucocele of the glands of Blandin-Nuhn. There was a female predominance, and most patients were younger than 20 years. Fifteen patients first visited a medical doctor and 9 visited a dentist before being referred to our department. The average duration from the time the lesion was first noticed to the patient's visit was 3.6 months. All lesions were located on the ventral surface of the tongue. In 17 patients, mucoceles were seen at the tip of the tongue, whereas 9 lesions occurred more posteriorly. Lesions were situated at the midline in 19 patients and laterally in 7 patients. All lesions presented as an exophytic mass, often with a polypoid appearance. All mucoceles were histopathologically of the extravasation type, suggesting that trauma may represent a frequent initiating factor.
  • Primary localized amyloidosis of the angle of mouth: Report of a case
    Noguchi T, Jinbu Y, Sakurai S, Kusama M
    Oral Med Pathol 8 27 - 30 2003
  • N Umemoto, T Demitsu, S Toda, M Ohsawa, T Noguchi, M Kakurai, T Yamada, M Suzuki, H Nakagawa, A Komai, T Hashimoto
    DERMATOLOGY 207 (1) 61 - 64 1018-8665 2003 [Refereed][Not invited]
     
    A 35-year-old Japanese woman had recurrent, pruritic, vesicular lesions on the face, neck and upper back as well as erosive lesions of the oral cavity and genitalia. The skin and mucosal lesions healed without scarring upon the systemic administration of corticosteroid and azathioprine. Direct immunofluorescence revealed linear deposits of IgG, IgA and C3 at the cutaneous basement membrane zone. indirect immunofluorescence on 1 M NaCl-split human skin sections demonstrated that the patient's IgG antibodies reacted with the dermal side of the split, while IgA antibodies weakly reacted with the epidermal side. By immunoblot analyses, the patient's serum reacted with the NC1 domain of type VII collagen as well as both the alpha(3)- and beta(3)-Subunits of laminin 5. We regarded our case as a nonscarring subepidermal blistering disease with autoantibodies to both type VII collagen and two different subunits of laminin 5. Such a case has not been previously reported. Copyright (C) 2003 S. Karger AG, Basel.
  • Y Abiko, Y Jinbu, T Noguchi, M Nishimura, K Kusano, P Amaratunga, T Shibata, T Kaku
    PATHOLOGY RESEARCH AND PRACTICE 198 (8) 537 - 542 0344-0338 2002 [Refereed][Not invited]
     
    Human beta defensin 2 (hBD-2) is a major antimicrobial peptide that is produced by many types of epithelial cells, and is transcriptionally inducible by various proinflammatory agents, such as cytokines and bacteria. Although in vitro studies of the hBDs in oral epithelial cells have been well documented, only little is known about the in vivo pathological state of oral epithelium. We investigated the localization of hBD-2 peptide in tissue sections of oral lichen planus, leukoplakia, candidal leukoplakia and radicular cysts using immunohistochemistry. HBD-2 was stained in both the hyperkeratinized and the granular layers in cases of lichen planus with hyperkeratosis and leukoplakia. Expression in spinous and suprabasal layers was often strong in lichen planus. There were no significant differences in the number of S-100 positive dendritic cells between the widely stained areas and those with limited staining areas in lichen planus. In cases of candidal leukoplakia, the hyphae of candida were mainly detected on the surface of keratinization, which showed only negative or faint staining for hBD-2. These results suggest that hBD-2 is vigorously induced by lichen planus-related inflammation and that it plays an important role in protection from Candida albicans infection; however, it is not a strong chemotactic attractant for Langerhans cells in pathological conditions of oral epithelium.
  • Y Kimura, Y Akasaka, H Itoh, O Aoyagi, A Ikeda, A Numao, T Noguchi, K Matsumoto, S Watanabe, H Naito, Y Jinbu, K Ohashi
    17TH INTERNATIONAL CANCER CONGRESS, VOL 1 AND 2 1345 - 1349 1998 [Refereed][Not invited]

MISC

  • 口腔に生じた疣贅型黄色腫の2例ならびに本邦報告例に関する臨床的検討
    山下 雅子, 神部 芳則, 野口 忠秀, 槻木 恵一, 森 良之  日本口腔内科学会雑誌  22-  (1)  29  -35  2016/06  [Not refereed][Not invited]
     
    疣贅型黄色腫は泡沫細胞あるいはxanthoma cellの増殖を特徴とし、一般には真の腫瘍ではなく、反応性変化と考えられている。今回われわれは、口腔内に生じた疣贅型黄色腫の2例を経験した。本邦例についての臨床的検討を行ったので併せて報告する。症例1:83歳、女性。右下顎歯肉の外向性腫瘤。症例2:69歳、女性。舌下面の有茎性腫瘤。2例とも切除術を施行し、病理組織学的に疣贅型黄色腫の診断であった。(著者抄録)
  • パノラマX線画像による頸動脈の石灰化の評価
    篠崎 泰久, 神部 芳則, 大田原 宏美, 早坂 純一, 土屋 欣之, 野口 忠秀, 森 良之, 伊藤 弘人, 飯田 幸弘, 勝又 明敏  歯科放射線  56-  (増刊)  73  -73  2016/06  [Not refereed][Not invited]
  • Yasuhisa Shinozaki, Yoshinori Jinbu, Hiroto Ito, Tadahide Noguchi, Mikio Kusama, Naoyuki Matsumoto, Kazuo Komiyama, Nobuyuki Taniguchi  ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY  118-  (4)  511  -511  2014/10  [Not refereed][Not invited]
  • 去川俊二, 野口忠秀, 西野宏, 菅原康志  日本口腔インプラント学会誌  27-  (1)  4  -9  2014/03  [Not refereed][Not invited]
  • 口腔に生じた疣贅型黄色腫の2例
    山下 雅子, 神部 芳則, 柏崎 明子, 伊藤 弘人, 野口 忠秀, 槻木 恵一, 草間 幹夫  日本口腔診断学会雑誌  27-  (1)  97  -97  2014/02  [Not refereed][Not invited]
  • HAYASHI HIROMI, SHINOZAKI YASUHISA, JIMBU YOSHINORI, HAYASAKA JUN'ICHI, TSUCHIYA YOSHIYUKI, ITO HIROTO, NOGUCHI TADAHIDE, KUSAMA MIKIO, IIDA YUKIHIRO, KATSUMATA AKITOSHI  Jpn J Diagn Imaging  32-  (1)  102  2014/02  [Not refereed][Not invited]
  • 去川俊二, 加持秀明, 野口忠秀, 西野宏, 菅原康志  日本口腔腫瘍学会総会・学術大会プログラム・抄録集  32nd-  145  2014  [Not refereed][Not invited]
  • 去川俊二, 大谷津幸生, 野口忠秀, 西野宏, 菅原康志  日本口腔腫よう学会誌  25-  (4)  185  -190  2013/12  [Not refereed][Not invited]
  • 口腔に生じた疣贅型黄色腫の2例
    山下 雅子, 神部 芳則, 柏崎 明子, 伊藤 弘人, 野口 忠秀, 槻木 恵一, 草間 幹夫  日本口腔内科学会雑誌  19-  (2)  96  -96  2013/12  [Not refereed][Not invited]
  • Shunji Sarukawa, Tadahide Noguchi, Kunio Miyazaki, Hiroto Itoh, Hiroshi Nishino, Mikio Kusama, Yasushi Sugawara, Kazumi Kawada  Japanese Journal of Head and Neck Cancer  39-  (3)  374  -378  2013/10  [Not refereed][Not invited]
     
    This is a retrospective case series study to develop a simple, standard, and more objective tool for speech intelligibility evaluation in Japanese patients following tongue reconstruction after a glossectomy for oral cancer. Speech samples consisting of a single-sentence utterance plus counting 1 through 10, 5 consonant-vowel pairs(for /t/, /s/, /k/, /g/, /r/, and /p/ groups), and diadochokinesis were recorded by 10 native-Japanese speakers who underwent tongue reconstruction surgery. Five medical personnel rated their speech intelligibility using a visual analogue scale (VAS) for the sentence plus counting sample, and assigned a score of 0-3 for the consonant-vowel pairs and a score of 0 or more for diadochokinesis. The VAS scores of all 5 raters were positively correlated with each other. The total correlation coefficient between the mean VAS score and total intelligibility score was highest for the consonant-vowel pairs of /t/, /k/, and /r/, indicating speech samples using these pairs best correlated with everyday speech. On the basis of these findings, the test items for the newly developed evaluation tool, named the TKR Speech Test, were finalized as the /t/, /k/, and /r/ consonant-vowel pairs, each scored 0-3. The TKR Speech Test shows promise as a simple yet accurate tool for speech intelligibility evaluation in Japanese patients following tongue reconstruction surgery.
  • 口腔扁平上皮癌に対する時間治療 DCF療法に伴う有害反応軽減の試み
    井岡 友梨, 牛島 健太郎, 野口 忠秀, 神部 芳則, 草間 幹夫, 藤村 昭夫  臨床薬理の進歩  (34)  58  -63  2013/06  [Not refereed][Not invited]
     
    DCF療法が予定されている口腔扁平上皮癌患者を対象にして、ドセタキセルおよびシスプラチンを従来のように昼間に投与した場合と、新たに夕方-夜間に投与した場合を比較し、有害反応の出現頻度やその程度に両群間で相違があるか検討した。前向き無作為非盲検臨床試験を開始し、口腔篇平上皮癌でDCF治療を行う入院患者を対象とした。DCF療法中にgrade 3-4の好中球減少が通常治療群で5例認めたのに対し、時間治療群では2例のみであった。それに伴ってG-CSF療法の回数は通常治療群で5.6±1.1回に対し、時間治療群では4.6±2.1回に抑えられた。整腸剤を使用した症例は時間治療群で少ない傾向にあった。嘔吐は両群で重篤なものは出現しなかったが、grade 1-2の嘔吐は通常治療群3例、時間治療群1例であった。口内炎に関しては、grade 3-4のものは通常治療群4例、時間治療群1例であった。
  • 去川俊二, 野口忠秀, 西野宏, 加持秀明, 須永中, 宇田宏一, 菅原康志  頭けい部癌  39-  (2)  127  2013/05  [Not refereed][Not invited]
  • 去川俊二, 野口忠秀, 西野宏, 加持秀明, 須永中, 宇田宏一, 菅原康志  日本マイクロサージャリー学会学術集会プログラム・抄録集  40th-  143  2013  [Not refereed][Not invited]
  • 去川俊二, 野口忠秀, 西野宏, 宮崎邦夫, 須永中, 宇田宏一, 菅原康志  日本形成外科学会総会・学術集会プログラム・抄録集  56th-  265  2013  [Not refereed][Not invited]
  • 大谷津幸生, 野口忠秀, 宮城徳人, 篠崎泰久, 早坂純一, 中山竜司, 土屋欣之, 伊藤弘人, 去川俊二, 西野宏, 神部芳則, 草間幹夫  日本口腔腫瘍学会総会・学術大会プログラム・抄録集  31st-  144  2013  [Not refereed][Not invited]
  • 去川俊二, 大谷津幸生, 野口忠秀, 宮崎邦夫, 西野宏, 草間幹夫, 菅原康志  日本口腔腫瘍学会総会・学術大会プログラム・抄録集  31st-  76  -77  2013  [Not refereed][Not invited]
  • 線毛上皮の出現を伴った下顎智歯含歯性嚢胞の1例
    小澤 通子, 早坂 純一, 林 宏美, 伊藤 弘人, 野口 忠秀, 神部 芳則, 槻木 恵一, 草間 幹夫  日本口腔科学会雑誌  62-  (1)  110  -111  2013/01  [Not refereed][Not invited]
  • 去川俊二, 宮崎邦夫, 須永中, 大谷津幸生, 野口忠秀, 西野宏, 草間幹夫, 菅原康志  頭けい部癌  38-  (2)  156  2012/05  [Not refereed][Not invited]
  • 大谷津幸生, 野口忠秀, 宮城徳人, 篠崎泰久, 土屋欣之, 伊藤弘人, 去川俊二, 西野宏, 神部芳則, 草間幹夫  頭けい部癌  38-  (2)  155  2012/05  [Not refereed][Not invited]
  • 大谷津幸生, 野口忠秀, 宮城徳人, 篠崎泰久, 土屋欣之, 伊藤弘人, 去川俊二, 西野宏, 神部芳則, 草間幹夫  日本口腔腫瘍学会総会・学術大会プログラム・抄録集  30th-  165  2012  [Not refereed][Not invited]
  • 去川俊二, 野口忠秀, 西野宏, 宮崎邦夫, 須永中, 宇田宏一, 菅原康志  日本頭蓋顎顔面外科学会学術集会プログラム・抄録集  30th-  10  2012  [Not refereed][Not invited]
  • 去川俊二, 野口忠秀, 伊藤弘人, 西野宏, 草間幹夫, 菅原康志  日本口腔腫瘍学会総会・学術大会プログラム・抄録集  30th-  159  2012  [Not refereed][Not invited]
  • 去川俊二, 野口忠秀, 西野宏, 宮崎邦夫, 須永中, 宇田宏一, 菅原康志  日本マイクロサージャリー学会学術集会プログラム・抄録集  39th-  251  2012  [Not refereed][Not invited]
  • 去川俊二, 野口忠秀, 西野宏, 宮崎邦夫, 須永中, 宇田宏, 菅原康志  日本形成外科学会総会・学術集会プログラム・抄録集  55th-  206  2012  [Not refereed][Not invited]
  • 去川俊二, 須永中, 宇田宏一, 伊藤弘人, 野口忠秀, 西野宏, 草間幹夫, 菅原康志  頭けい部癌  37-  (2)  326  2011/05  [Not refereed][Not invited]
  • 去川俊二, 須永中, 宇田宏一, 野口忠秀, 西野宏, 草間幹夫, 菅原康志  日本形成外科学会総会・学術集会プログラム・抄録集  54th-  231  2011  [Not refereed][Not invited]
  • 杉山 知子, 神部 芳則, 伊藤 弘人, 野口 忠秀, 草間 幹夫, 窪田 展久, 槻木 恵一  日本口腔科学会雑誌  60-  (1)  125  -126  2011/01  [Not refereed][Not invited]
  • N. Ryuji, H. Itoh, A. Ymazaki, T. Noguchi, Y. Jinbu, M. Kusama  ORAL ONCOLOGY  163  -163  2009/07  [Not refereed][Not invited]
  • 口腔扁平苔癬におけるuPA、uPAR、MMPs(MMP-2、MMP-3、MMP-9)発現の免疫組織化学的検討
    三田村 治郎, 神部 芳則, 野口 忠秀, 槻木 恵一, 内藤 浩美, 大橋 一之, 草間 幹夫  日本口腔粘膜学会雑誌  15-  (1)  9  -14  2009/06  [Not refereed][Not invited]
     
    口腔扁平苔癬(OLP)15例の生検材料を用いてuPA、uPAR、MMPs(MMP-2、MMP-3、MMP-9)発現細胞の局在を免疫組織化学的に検討した。その結果、uPAは主にOLP上皮組織の有棘細胞層から基底層にかけて発現が認められた。また、uPARはマクロファージ、有棘細胞層から基底層にかけての細胞膜上の一部に発現が認められ、MMP-2、MMP-3の発現部位はuPAとほぼ一致した。更にMMP-9は炎症性変化が強く、基底膜や上皮組織のみられる部位に特に強く発現がみられた。以上、これらのことからuPA、uPAR、MMPsの相互作用により、OLPの病態形成に関与することが考えられた。
  • 去川俊二, 野口忠秀, 西野宏, 草間幹夫, 石川和宏, 伊藤弘人, 須永中, 宇田宏一, 菅原康志  頭けい部癌  35-  (2)  109  2009/05  [Not refereed][Not invited]
  • Naruo Okada, Kenichi Sasaguri, Takero Otsuka, Akifumi Fujita, Hiroto Ito, Tadahide Noguchi, Yoshinori Jinbu, Mikio Kusama, Minoru Onozuka  NEUROSCIENCE RESEARCH  65-  S131  -S131  2009  [Not refereed][Not invited]
  • 去川俊二, 野口忠秀, 西野宏, 草間幹夫, 菅原康志  日本口腔腫瘍学会総会・学術大会プログラム・抄録集  27th-  85  2009  [Not refereed][Not invited]
  • 去川俊二, 野口忠秀, 西野宏, 草間幹夫, 石川和宏, 伊藤弘人, 須永中, 宇田宏一, 菅原康志  日本頭蓋顎顔面外科学会学術集会プログラム・抄録集  27th-  133  2009  [Not refereed][Not invited]
  • 口腔扁平苔癬および白板症におけるstathminの発現に関する臨床病理学的検討
    小尾 友梨, 神部 芳則, 池田 薫, 伊藤 弘人, 野口 忠秀, 槻木 恵一, 草間 幹夫  日本口腔粘膜学会雑誌  13-  (2)  94  -94  2007/12  [Not refereed][Not invited]
  • 癌のリンパ節転移 舌扁平上皮癌におけるSODの発現についての免疫組織化学的検討
    小尾 友梨, 神部 芳則, 仙名 智弘, 伊藤 弘人, 野口 忠秀, 松本 浩一, 三田村 治郎, 槻木 恵一, 草間 幹夫  日本口腔科学会雑誌  56-  (1)  123  -123  2007/01  [Not refereed][Not invited]
  • 嚢胞腔内に多量の石灰化物を含んだ含歯性嚢胞の1例
    松村 俊男, 神部 芳則, 福島 聡, 平塚 正樹, 槻木 恵一, 野口 忠秀, 草間 幹夫  日本口腔外科学会雑誌  52-  (12)  781  -782  2006/12  [Not refereed][Not invited]
  • 口腔扁平上皮癌、扁平苔癬、白板症におけるsurvivinの発現
    小尾 友梨, 神部 芳則, 松本 浩一, 野口 忠秀, 槻木 恵一, 草間 幹夫  日本口腔粘膜学会雑誌  12-  (2)  110  -110  2006/12  [Not refereed][Not invited]
  • 犬咬傷による口角、上唇欠損を頬粘膜advance flapにより再建した1例
    福島 聡, 土屋 欣之, 小佐野 仁志, 野口 忠秀, 宮城 徳人, 伊藤 弘人, 草間 幹夫  日赤医学  58-  (1)  363  -363  2006/10  [Not refereed][Not invited]
  • 口腔扁平苔癬におけるSODの発現に関する免疫組織学的検討
    野口 忠秀, 神部 芳則, 三田村 治郎, 槻木 恵一, 草間 幹夫  日本口腔粘膜学会雑誌  11-  (2)  48  -53  2005/12  [Not refereed][Not invited]
     
    口腔扁平苔癬(OLP)におけるスーパーオキシドジスムターゼ(SOD)の局在について検討し,OLPの臨床病理学的所見との関連についても比較検討した.20症例を対象にした結果,OLP病変部では正常粘膜に比べてSODの発現の増強を認めた.特にlichenoid dysplasia(LD)を示していた2症例では,SODのマンガン型酵素(Mn-S0D),銅亜鉛型酵素(Cu/Zn-S0D)の発現の増強を認め,2年以内に扁平上皮癌が発生した.臨床型は網状型,糜爛型,白板型の3タイプを認め,網状型でMn-S0Dの発現が強い傾向にあった.他のタイプは臨床型とS0Dの発現に明らかな関連は認めなかった.病理組織学的にはSODと明らかな相関は認めなかった.以上により,OLPの病態形成には細胞性免疫機構の他に種々の修飾因子が関与し,フリーラジカルや抗酸化酵素などのスカベンジャーもこの一因と考え,スーパーオキシドは上皮の異形成変化や発癌へのプロモーター作用もあることが推察された
  • 口腔扁平苔癬におけるuPA.MMP(-2,-3,-9)発現の免疫組織学的検討
    三田村 治郎, 内藤 浩美, 大橋 一之, 野口 忠秀, 神部 芳則, 草間 幹夫, 槻木 恵一, 渡辺 是久  日本口腔粘膜学会雑誌  11-  (2)  92  -92  2005/12  [Not refereed][Not invited]
  • 口腔扁平苔癬におけるSODの発現に関する検討
    野口 忠秀, 神部 芳則, 三田村 治郎, 槻木 恵一, 草間 幹夫  日本口腔粘膜学会雑誌  11-  (2)  92  -92  2005/12  [Not refereed][Not invited]
  • 口腔扁平苔癬におけるUPA,MMP-9発現の免疫組織学的検討
    三田村 治郎, 内藤 浩美, 大橋 一之, 野口 忠秀, 神部 芳則, 草間 幹夫, 槻木 恵一, 渡辺 是久  日本口腔科学会雑誌  54-  (4)  518  -518  2005/09  [Not refereed][Not invited]
  • 顎顔面非対称ならびに咬合偏位をきたした下顎頭骨腫の1治療例
    野口 忠秀, 神部 芳則, 笹栗 健一, 槻木 恵一, 小林 馨, 草間 幹夫  日本口腔外科学会雑誌  51-  (Suppl.)  145  -145  2005/09  [Not refereed][Not invited]
  • 口腔扁平上皮癌に対する放射線docetaxel,CDDP,5-FU(DCF)同時併用療法
    小尾 友梨, 松本 浩一, 野口 忠秀, 池田 敦, 星 健太郎, 土屋 欣之, 小佐野 仁志, 大森 正規, 藤村 昭夫, 柴山 千秋, 仲澤 聖則, 草間 幹夫  日本口腔科学会雑誌  54-  (1)  125  -125  2005/01  [Not refereed][Not invited]
  • N Umemoto, T Demitsu, S Toda, T Noguchi, SI Suzuki, M Kakurai, T Yamada, M Suzuki, H Nakagawa, A Komai, T Hashimoto  BRITISH JOURNAL OF DERMATOLOGY  148-  (5)  1058  -1060  2003/05  [Not refereed][Not invited]
  • Keiju Tsubaki, Kousuke Ishii, Kouichi Abe, Masanori Yamamoto, Masashi Haga, Tadahide Noguchi  Practica Oto-Rhino-Laryngologica  95-  (10)  1059  -1063  2002  [Not refereed][Not invited]
     
    Improvements in subjective symptoms, changes in the apnea index (AI), and complications were studied in patients with obstructive sleep apnea syndrome (OSAS) who were treated with nasal continuous positive airway pressure (nCPAP) or a mandibular advancement splint (MAS). Subjects: The subjects consisted of 32 patients (30 males and 2 females) with habitual snoring and sleep apnea. Methods: AI was measured using an apnea monitor (APNOMONITOR II®, Chest Co.). Sleep apnea was defined as the cessation of respiration for 10 seconds or longer during sleep. Complications, improvements in subjective symptoms and changes in AI were investigated during and after each treatment. Results: Subjective symptoms improved in 24 of 25 patients undergoing nCPAP treatment. Meanwhile, subjective symptoms disappeared or improved in all patients receiving MAS. AI improved in 21 of 25 patients with nCPAP and in all patients with MAS. As complications of nCPAP, xerostomia was noted in 4 patients, breathing difficulty in 4 and recurrent arousal in 3. In contrast, temporomandibular arthralgia was noted in only 3 patients with MAS. Conclusion: The continuity rate of MAS was high and its efficacy was comparable to that of nCPAP in patients with OSAS.
  • 大多和薫, 野口忠秀, 伊藤弘人, 松本浩一, 大橋一之, 内藤浩美, 神部芳則, 赤坂庸子, 草間幹夫  日本小児口腔外科学会雑誌  11-  (2)  62  -70  2001  [Not refereed][Not invited]
  • 歯肉出血を主訴に来院した先天性第Ⅴ因子欠乏症の2例
    日本口腔診断学会雑誌  14-  (2)  460  -463  2001  [Not refereed][Not invited]
  • 病理組織学的に軟骨の増殖を伴った茎状突起過長症の1例
    日本口腔診断学会雑誌  14-  (2)  455  -459  2001  [Not refereed][Not invited]
  • 口腔に生じた膿原性肉芽腫20例の臨床的検討
    日本口腔粘膜学会  7-  (1)  20  -25  2001  [Not refereed][Not invited]
  • 画像診断と病理
    画像診断  21-  (2)  122  -123  2001  [Not refereed][Not invited]
  • オトカイ下,顎下部の腫瘤を主訴に来院した猫ひっかき病の2例
    日本口腔診断学会雑誌  14-  (1)  118  -122  2001  [Not refereed][Not invited]
  • Hiromi NAITO, Yoshinori JINBU, Tadahide NOGUCHI, Fumiko KIRIKAE, Teruo KIRIKAE, Hideo YAOITA, Yoko AKASAKA  Journal of the Japanese stomatological society  50-  (1)  19  -25  2001  [Not refereed][Not invited]
  • Two cases of cat scratch disease with submental and submandibular mass lesions
    Japanese Journal of oral diagnosis/oral medicine  14-  (1)  118  -122  2001  [Not refereed][Not invited]
  • Noguchi T, Jinbu Y, Naito H, Akasaka Y, Yaoita, H  Journal of the Japanese stomatological Society  49-  (4)  239  -245  2000  [Refereed][Not invited]
  • 正常口腔粘膜および表皮における水疱性類天疱瘡抗原(BPAG (]G0001[),BPAG (]G0002[))の発現状態の相違について
    日本口腔粘膜学会誌  5-  (2)  49  -53  1999  [Not refereed][Not invited]
  • 口腔扁平苔癬におけるICAM-lの発現
    日本口腔診断学会誌  12-  (1)  279  -283  1999  [Not refereed][Not invited]
  • CDPP,5PU併用療法が著効を示した口蓋小唾液腺由来の末分化療の1例
    日本口腔診断学会雑誌  12-  (1)  174  -177  1999  [Not refereed][Not invited]
  • 腫瘍が凝われた顎放線菌症の1例
    日本口腔診断学会雑誌  12-  (1)  140  -143  1999  [Not refereed][Not invited]
  • Difference in Expression of Bullous Pemphigoid Antigen(BPAG(]G0001[),BPAG(]G0002[))between Normal Oral Mucosa and Skin.
    Jaurnal of Japanese Society for oral mucous membrane  5-  (2)  49  -53  1999  [Not refereed][Not invited]
  • The Expression Pottern of ICAM-l in Oral Lichen planus
    Japanese Journal of Oral diagnosis/Oral Medicine  12-  (1)  279  -283  1999  [Not refereed][Not invited]
  • A Case of Undifferentiated Carcinoma Arising in the Palatal Minor Salivary Gland, Successfully Treated by Chematherapy with CDDP and 5FU
    Japanese Journal of oral diagnosis/oral medicine  12-  (1)  174  -177  1999  [Not refereed][Not invited]
  • A case of Actinomycosis of the Mandible with Suspected as cheek Tumor
    Japanese Journal of Oral diagnosis/oral Medicine  12-  (1)  140  -143  1999  [Not refereed][Not invited]
  • 病理組織学的に骨軟骨腫の所見を示した茎状突起過長症の1例
    池田 敦, 神部 芳則, 野口 忠秀, 赤坂 庸子, 槻木 恵一, 曽田 忠雄  日本口腔科学会雑誌  47-  (3)  436  -436  1998/07  [Not refereed][Not invited]
  • ビタミンB12欠乏症による薬縮性舌先の2例
    日本口腔診断学会雑誌  11-  (1)  98  -102  1998  [Not refereed][Not invited]
  • Two cases of Atrophic Glossitis Due to Vitamin B12 Deficiency
    Japanese Journal of oral diagnosis/oral medicine  11-  (1)  98  -102  1998  [Not refereed][Not invited]
  • H Naito, Y Jinbu, T Noguchi, Y Akasaka, H Yaoita  JOURNAL OF DENTAL RESEARCH  76-  2779  -2779  1997  [Not refereed][Not invited]
  • 野口 忠秀, 赤坂 庸子, 神部 芳則, 内藤 浩美, 大橋 一之, 石井 明  日本口腔科学会雑誌  46-  (4)  404  -408  1997  [Not refereed][Not invited]
  • ヒト正常口腔粘膜上皮におけるケラチンの発現状態の検討
    日本口腔粘膜学会誌  3-  (1)  19  -26  1997  [Not refereed][Not invited]
  • Tadahide NOGUCHI, Yoko AKASAKA, Yoshinori JINBU, Hiromi NAITOH, Kazuyuki OHASHI, Akira ISHII  Journal of the Japanese stomatological Society  46-  (4)  404  -408  1997  [Not refereed][Not invited]
  • Study on expression pattem of cytokeratims in human normal oral mucsa
    Journal of Japanese Society for oral mucous membrane  3-  (1)  19  -26  1997  [Not refereed][Not invited]
  • Y Jinbu, T Noguchi, H Koyano, T Shimamura, Y Akasaka, H Yaoita  JOURNAL OF DENTAL RESEARCH  75-  2500  -2500  1996  [Not refereed][Not invited]
  • 野口忠秀, 神部芳則, 古谷野浩美, 赤坂庸子, 矢尾板英夫  日本口腔科学会誌  45-  (4)  442  -447  1996  [Not refereed][Not invited]
  • 口腔扁平苔癬と肝機能異常に関する臨床統計的検討
    日本口腔粘膜学会雑誌  2-  (1)  36  -41  1996  [Not refereed][Not invited]
  • 特異な病理組織像を示した口腔内びらんの1例
    日本口腔診断学会雑誌  9-  (1)  154  -159  1996  [Not refereed][Not invited]
  • 神部芳則, 大久保幸重, 古谷野浩美, 野口忠秀, 赤坂庸子  日本口腔科学会雑誌  45-  (2)  190  -193  1996  [Not refereed][Not invited]
  • Differences in the Expression Pattern between Integrins and E-Cadherir after Cytochalasin B Treatment in Cultured Human Gingival Keratinocytes.
    The Bulletin of Kanagawa Dental College  24-  (2)  77  -82  1996  [Not refereed][Not invited]
  • Journal of the Japanese stomatological society  45-  (4)  442  -447  1996  [Not refereed][Not invited]
  • A case of oral erosion which showed cnusual histopathological findings.
    Japanese journal of oral diagnosis/oral medicine.  9-  (1)  154  -159  1996  [Not refereed][Not invited]
  • Journal of the Japanese stomatological Society  45-  (2)  190  -193  1996  [Not refereed][Not invited]
  • H YAOITA, Y JINBU, H KOYANO, T NOGUCHI, Y AKASAKA  JOURNAL OF INVESTIGATIVE DERMATOLOGY  105-  (3)  476  -476  1995/09  [Not refereed][Not invited]
  • 古谷野 浩美, 神部 芳則, 野口 忠秀, 赤坂 庸子, 矢尾板 英夫  日本口腔科学会雑誌  44-  (4)  596  -602  1995  [Not refereed][Not invited]
  • 水疱性類天疱瘡および尋常性天疱瘡による口腔病変の分布に関する比較検討
    日本口腔診断学会雑誌  8-  (2)  511  -515  1995  [Not refereed][Not invited]
  • 日本口腔外科学会雑誌  41-  (12)  1083  -1085  1995  [Not refereed][Not invited]
  • 野口 忠秀, 赤坂 庸子, 小佐野 仁志  日本口腔科学会雑誌  44-  (3)  450  -454  1995  [Not refereed][Not invited]
  • Distribution of Adhesion Molecules in Human Normal Oral Mucosa and Cultured Gingival Keratinocytes
    Oral Oncology  (]G0004[)-  (B)  149  -152  1995  [Not refereed][Not invited]
  • Hiromi KOYANO, Yoshinori JINBU, Tadahide NOGUCHI, Yoko AKASAKA, Hideo YAOITA  Journal of the Japanese stomatological Society  44-  (4)  596  -602  1995  [Not refereed][Not invited]
  • Comperatine study of the intraoral distribution of the lesions with bullous penphigoil and pemphigis Vulgaris.
    Japanese journal of oral diagnosis/oral medicine.  8-  (2)  511  -515  1995  [Not refereed][Not invited]
  • Hitoshi OSANO, Tadahide NOGUCHI, Kazuyuki OOHASHI, Shigeaki KOTO, Yoko AKASAKA, Kazuo KOMIYAMA  Japanese jornal of oral maxillofocial surgeny  41-  (12)  1083  -1085  1995  [Not refereed][Not invited]
  • Tadahide NOGUCHI, Yoko AKASAKA, Hitoshi OSANO  Journal of the Japanese stomatological Society  44-  (3)  450  -454  1995  [Not refereed][Not invited]
  • 赤坂 庸子, 神部 芳則, 古谷野 浩美, 野口 忠秀  日本口腔外科学会雑誌  39-  (8)  943  -945  1993  [Not refereed][Not invited]
  • 歯科口腔外科領域における薬物療法時の消化器症状発現に対する防止効果ガスロンによる検討
    歯界展望  82,1243-1250-  1993  [Not refereed][Not invited]
  • Yoko AKASAKA, Yoshinori JINBU, Hiromi KOYANO, Tadahide NOGUCHI  Japanese journal of oral mxillofocial Surgeny  39-  (8)  943  -945  1993  [Not refereed][Not invited]

Research Grants & Projects

  • FDG-PETによる口腔癌診断についての研究
  • 口腔粘膜疾患の発生機序についての研究
  • 白血病患者の口腔内管理についての研究
  • 口腔粘膜天疱瘡の研究
  • ヒト口腔粘膜におけるリンパ球の接着機序の解明
  • Study of FDG-PET in oral cancer
  • Study on oral management in patients with Leukemia
  • Study on pemphigus of the oral mucosa
  • Study on adhesion mechanism of lymphorytes in oral mucosa.


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