hayakawa morisada

FacultyBiochemistryMedicalBiochemistry
Job titleAssistant ProfessorWeb sitehttp://www.jichi.ac.jp/biochem/byotai/index.html

Profile

Research Keywords

    Allergy, Gene Expression, Asthma, Cytokine

Research Areas

  • Biological science / Molecular biology
  • Basic medicine / Pathological medical chemistry
  • Basic medicine / Immunology

Career

  • Apr.2000
    -
    Sep.2005
    Jichi Medical University School of Medicine, Research Associate
  • Oct.2005
    -
    Oct.2006
    Jichi Medical University School of Medicine, Assistant Professor
  • Feb.2009
    -
    Jan.2011
    Harvard Medical School Massachusetts General Hospital, Cutaneous Biology Research Center, Research Fellow
  • Jan.2011
    -
    Today
    Jichi Medical University School of Medicine, Graduate School of Medicine, Assistant Professor

Academic Background

  • -
    2000
    Graduate School, Division of Medicine, Jichi Medical University (japan)
  • -
    1995
    Materials Science, Japan Advanced Institute of Science and Technology
  • -
    1993
    Faculty of Agriculture and Veterinary Medicine, Nihon University (japan)

Academic Societies

  • The Molecular Biology Society of Japan
  • The Japanese Biochemical Society
  • Japanese Society of Interferon and Cytokine Research
  • American Society for Biochemistry and Molecular Biology
Display all
Academic Societiesclose
  • The Molecular Biology Society of Japan
  • The Japanese Biochemical Society
  • Japanese Society of Interferon and Cytokine Research
  • American Society for Biochemistry and Molecular Biology

Research Activities

Papers(paper)

  • Interleukin-4-induced β-catenin regulates the conversion of macrophages to multinucleated giant cells.
    Binder F, Hayakawa M, Choo MK, Sano Y, Park JM
    Molecular immunology 54 157-163 Jun. 2013
  • Presence of a novel exon 2E encoding a putative transmembrane protein in human IL-33 gene.
    Tominaga S, Hayakawa M, Tsuda H, Ohta S, Yanagisawa K
    Biochemical and biophysical research communications 430 969-974 Jan. 2013
  • YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation.
    Miwa A, Takezako N, Hayakawa H, Hayakawa M, Tominaga S, Yanagisawa K
    American journal of hematology 87 1084-1088 Dec. 2012
  • Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease.
    Ritprajak P, Hayakawa M, Sano Y, Otsu K, Park JM
    Proceedings of the National Academy of Sciences of the United States of America 109 9089-9094 Jun. 2012
  • Characterization of ST2 transgenic mice with resistance to IL-33.
    Ohto-Ozaki H, Kuroiwa K, Mato N, Matsuyama Y, Hayakawa M, Tamemoto H, Tominaga S
    European journal of immunology 40 2632-2642 Sep. 2010
  • ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells.
    Aoki S, Hayakawa M, Ozaki H, Takezako N, Obata H, Ibaraki N, Tsuru T, Tominaga S, Yanagisawa K
    Molecular and cellular biochemistry 335 75-81 Feb. 2010
  • Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis.
    Matsuyama Y, Okazaki H, Tamemoto H, Kimura H, Kamata Y, Nagatani K, Nagashima T, Hayakawa M, Iwamoto M, Yoshio T, Tominaga S, Minota S
    The Journal of rheumatology 37 18-25 Jan. 2010
  • Mature interleukin-33 is produced by calpain-mediated cleavage in vivo.
    Hayakawa M, Hayakawa H, Matsuyama Y, Tamemoto H, Okazaki H, Tominaga S
    Biochemical and biophysical research communications 387 218-222 Sep. 2009
  • Interleukin-1 receptor-related protein ST2 suppresses the initial stage of bleomycin-induced lung injury.
    Mato N, Fujii M, Hakamata Y, Kobayashi E, Sato A, Hayakawa M, Ohto-Ozaki H, Bando M, Ohno S, Tominaga S, Sugiyama Y
    The European respiratory journal 33 1415-1428 Jun. 2009
  • TRAF6 is a critical signal transducer in IL-33 signaling pathway.
    Funakoshi-Tago M, Tago K, Hayakawa M, Tominaga S, Ohshio T, Sonoda Y, Kasahara T
    Cellular signalling 20 1679-1686 Sep. 2008
Display all
Papers(paper)close
  • Interleukin-4-induced β-catenin regulates the conversion of macrophages to multinucleated giant cells.
    Binder F, Hayakawa M, Choo MK, Sano Y, Park JM
    Molecular immunology 54 157-163 Jun. 2013
  • Presence of a novel exon 2E encoding a putative transmembrane protein in human IL-33 gene.
    Tominaga S, Hayakawa M, Tsuda H, Ohta S, Yanagisawa K
    Biochemical and biophysical research communications 430 969-974 Jan. 2013
  • YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation.
    Miwa A, Takezako N, Hayakawa H, Hayakawa M, Tominaga S, Yanagisawa K
    American journal of hematology 87 1084-1088 Dec. 2012
  • Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease.
    Ritprajak P, Hayakawa M, Sano Y, Otsu K, Park JM
    Proceedings of the National Academy of Sciences of the United States of America 109 9089-9094 Jun. 2012
  • Characterization of ST2 transgenic mice with resistance to IL-33.
    Ohto-Ozaki H, Kuroiwa K, Mato N, Matsuyama Y, Hayakawa M, Tamemoto H, Tominaga S
    European journal of immunology 40 2632-2642 Sep. 2010
  • ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells.
    Aoki S, Hayakawa M, Ozaki H, Takezako N, Obata H, Ibaraki N, Tsuru T, Tominaga S, Yanagisawa K
    Molecular and cellular biochemistry 335 75-81 Feb. 2010
  • Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis.
    Matsuyama Y, Okazaki H, Tamemoto H, Kimura H, Kamata Y, Nagatani K, Nagashima T, Hayakawa M, Iwamoto M, Yoshio T, Tominaga S, Minota S
    The Journal of rheumatology 37 18-25 Jan. 2010
  • Mature interleukin-33 is produced by calpain-mediated cleavage in vivo.
    Hayakawa M, Hayakawa H, Matsuyama Y, Tamemoto H, Okazaki H, Tominaga S
    Biochemical and biophysical research communications 387 218-222 Sep. 2009
  • Interleukin-1 receptor-related protein ST2 suppresses the initial stage of bleomycin-induced lung injury.
    Mato N, Fujii M, Hakamata Y, Kobayashi E, Sato A, Hayakawa M, Ohto-Ozaki H, Bando M, Ohno S, Tominaga S, Sugiyama Y
    The European respiratory journal 33 1415-1428 Jun. 2009
  • TRAF6 is a critical signal transducer in IL-33 signaling pathway.
    Funakoshi-Tago M, Tago K, Hayakawa M, Tominaga S, Ohshio T, Sonoda Y, Kasahara T
    Cellular signalling 20 1679-1686 Sep. 2008
  • Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation.
    Hayakawa H, Hayakawa M, Kume A, Tominaga S
    The Journal of biological chemistry 282 26369-26380 Sep. 2007
  • SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes.
    Fujii M, Lyakh LA, Bracken CP, Fukuoka J, Hayakawa M, Tsukiyama T, Soll SJ, Harris M, Rocha S, Roche KC, Tominaga S, Jen J, Perkins ND, Lechleider RJ, Roberts AB
    Molecular cell 24 771-783 Dec. 2006
  • ST2 suppresses IL-6 production via the inhibition of IkappaB degradation induced by the LPS signal in THP-1 cells.
    Takezako N, Hayakawa M, Hayakawa H, Aoki S, Yanagisawa K, Endo H, Tominaga S
    Biochemical and biophysical research communications 341 425-432 Mar. 2006
  • T-helper type 2 cell-specific expression of the ST2 gene is regulated by transcription factor GATA-3.
    Hayakawa M, Yanagisawa K, Aoki S, Hayakawa H, Takezako N, Tominaga S
    Biochimica et biophysica acta 1728 53-64 Apr. 2005
  • Molecular cloning of the chicken ST2 gene and a novel variant form of the ST2 gene product, ST2LV.
    Iwahana H, Hayakawa M, Kuroiwa K, Tago K, Yanagisawa K, Noji S, Tominaga S
    Biochimica et biophysica acta 1681 1-14 Nov. 2004
  • A novel splice variant of mouse interleukin-1-receptor-associated kinase-1 (IRAK-1) activates nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK).
    Yanagisawa K, Tago K, Hayakawa M, Ohki M, Iwahana H, Tominaga S
    The Biochemical journal 370 159-166 Feb. 2003
  • Muscle-specific exonic splicing silencer for exon exclusion in human ATP synthase gamma-subunit pre-mRNA.
    Hayakawa M, Sakashita E, Ueno E, Tominaga S, Hamamoto T, Kagawa Y, Endo H
    The Journal of biological chemistry 277 6974-6984 Mar. 2002
  • Presence of a genistein-responsive inhibitory mechanism on interleukin-1alpha-induced NF-kappaB activation.
    Tago K, Funakoshi M, Mano H, Yanagisawa K, Hayakawa M, Kuroiwa K, Iwahana H, Kasahara T, Tominaga S
    European journal of biochemistry / FEBS 268 6526-6533 Dec. 2001
  • Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V.
    Tago K, Noda T, Hayakawa M, Iwahana H, Yanagisawa K, Yashiro T, Tominaga S
    Biochemical and biophysical research communications 285 1377-1383 Aug. 2001
  • Differential regulation of exonic regulatory elements for muscle-specific alternative splicing during myogenesis and cardiogenesis.
    Ichida M, Hakamata Y, Hayakawa M, Ueno E, Ikeda U, Shimada K, Hamamoto T, Kagawa Y, Endo H
    The Journal of biological chemistry 275 15992-16001 May 2000
  • Acidic stimulation induces a negative regulatory factor that affects alternative exon selection in vitro in human ATP synthase gamma-subunit pre-mRNA.
    Hayakawa M, Endo H, Hamamoto T, Kagawa Y
    Biochemical and biophysical research communications 251 603-608 Oct. 1998
  • Genes of human ATP synthase: their roles in physiology and aging.
    Kagawa Y, Hamamoto T, Endo H, Ichida M, Shibui H, Hayakawa M
    Bioscience reports 17 115-146 Apr. 1997
  • Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
    Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani RV, Jiménez-Andrade GY, Sano Y, Choo MK, Seavitt J, Venigalla RK, Otsu K, Georgopoulos K, Arthur JS, Park JM
    The Journal of biological chemistry 292(5) 1762-1772 Feb. 2017
  • Soluble ST2 suppresses the effect of interleukin-33 on lung type 2 innate lymphoid cells.
    23) Hayakawa H, Hayakawa M, Tominaga S
    Biochem Biophys Rep 5 401-407 Mar. 2016

Papers(other)

  • Soluble ST2 controls allergic inflammation in a murine model of asthma
    HAYAKAWA Hiroko, HAYAKAWA Morisada, OHTO-OZAKI Hiromi, et al.
    FASEB JOURNAL 27 835.4 Apr. 2013
  • 新規サイトカインIL‐31,IL‐32,IL‐33―基礎と臨床―IL‐33の基礎とアレルギー性炎症の誘導
    HAYAKAWA Morisada, TOMINAGA Shin-ichi
    炎症と免疫 18(6) 579-584 Oct. 2010
  • インターロイキン-33
    HAYAKAWA Morisada, TOMINAGA Shin-ichi
    分子細胞治療 7 376-377 2008
  • Soluble ST2 suppresses ST2L-based IL-33 signaling pathway
    HAYAKAWA Morisada, HAYAKAWA Hiroko, KUME Akihiro, et al.
    CYTOKINE 39 14-15 Jul. 2007
  • Incadronate can induce apoptosis in monocytic cells
    MIWA Akiyoshi, TAKEZAKO Naoki, HAYAKAWA, Morisada, et al.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 92 135 Jun. 2007
  • ヘルパーT細胞(Th2)におけるST2遺伝子の発現制御機構の研究
    HAYAKAWA Morisada
    自治医科大学医学部紀要 25 114 Dec. 2002
  • ATP合成酵素γサブユニット遺伝子の筋特異的スプライシングのin vitro解析
    HAYAKAWA Morisada
    自治医科大学紀要 22 311 Dec. 1999
  • ATP synthase gamma subunits: Splicing in transgenic mice
    KAGAWA Yasuo, HAYAKAWA Morisada Cha SH, et al.
    FASEB JOURNAL 13 7 Apr. 1999
  • IL-33(Interleukin-33)
    HAYAKAWA Morisada
    日本生化学会会誌 83 253 2011
Display all
Papers(other)close
  • Soluble ST2 controls allergic inflammation in a murine model of asthma
    HAYAKAWA Hiroko, HAYAKAWA Morisada, OHTO-OZAKI Hiromi, et al.
    FASEB JOURNAL 27 835.4 Apr. 2013
  • 新規サイトカインIL‐31,IL‐32,IL‐33―基礎と臨床―IL‐33の基礎とアレルギー性炎症の誘導
    HAYAKAWA Morisada, TOMINAGA Shin-ichi
    炎症と免疫 18(6) 579-584 Oct. 2010
  • インターロイキン-33
    HAYAKAWA Morisada, TOMINAGA Shin-ichi
    分子細胞治療 7 376-377 2008
  • Soluble ST2 suppresses ST2L-based IL-33 signaling pathway
    HAYAKAWA Morisada, HAYAKAWA Hiroko, KUME Akihiro, et al.
    CYTOKINE 39 14-15 Jul. 2007
  • Incadronate can induce apoptosis in monocytic cells
    MIWA Akiyoshi, TAKEZAKO Naoki, HAYAKAWA, Morisada, et al.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 92 135 Jun. 2007
  • ヘルパーT細胞(Th2)におけるST2遺伝子の発現制御機構の研究
    HAYAKAWA Morisada
    自治医科大学医学部紀要 25 114 Dec. 2002
  • ATP合成酵素γサブユニット遺伝子の筋特異的スプライシングのin vitro解析
    HAYAKAWA Morisada
    自治医科大学紀要 22 311 Dec. 1999
  • ATP synthase gamma subunits: Splicing in transgenic mice
    KAGAWA Yasuo, HAYAKAWA Morisada Cha SH, et al.
    FASEB JOURNAL 13 7 Apr. 1999
  • IL-33(Interleukin-33)
    HAYAKAWA Morisada
    日本生化学会会誌 83 253 2011

Outside Fund Adoption

  • Expression and function of ST2 protein using a murine model of asthma
    :Grant-in-Aid for Scientific Research
  • Signaling pathway of interleukin-33
Display all
Outside Fund Adoptionclose
  • Expression and function of ST2 protein using a murine model of asthma
    :Grant-in-Aid for Scientific Research
  • Signaling pathway of interleukin-33


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